{"id":71267,"date":"2018-10-18T01:00:00","date_gmt":"2018-12-07T04:53:59","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/3a3318753f\/"},"modified":"2018-12-07T12:54:01","modified_gmt":"2018-12-07T04:54:01","slug":"3a3318753f","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/71267\/","title":{"rendered":"Pembrolizumab\u4e0eAxitinib\u8054\u7528\u4e8e\u4e00\u7ebf\u80be\u764c\u4e34\u5e8a\u8bd5\u9a8c\u8fbe\u6210\u9996\u8981\u7814\u7a76\u7ec8\u70b9"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section class=\"xmteditor\" style=\"display:none;\"  ><\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;color: rgb(62, 62, 62);font-size: 16px;white-space: normal;background-color: rgb(255, 255, 255);word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"padding-right: 10px;padding-left: 10px;max-width: 100%;box-sizing: border-box;line-height: 1.6;word-wrap: break-word !important;\">\n<section class=\"\" style=\"margin-top: 0.8em;margin-bottom: 0.5em;max-width: 100%;box-sizing: border-box;color: rgb(62, 62, 62);font-size: 16px;white-space: normal;background-color: rgb(255, 255, 255);border-width: 0px;border-style: initial;border-color: initial;text-align: center;word-wrap: break-word !important;\"><strong style=\"color: rgb(0, 122, 170);\">#PD-1<\/strong><\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section class=\"\" style=\"padding-right: 22px;padding-left: 22px;max-width: 100%;box-sizing: border-box;line-height: 1.6;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\"><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u4eca\u65e5MSD\u5ba3\u5e03<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u5176PD-1\u6291\u5236\u5242<strong><span style=\"color: rgb(0, 122, 170);\">Pembrolizumab<\/span><\/strong><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u4e0ePfizer\u65d7\u4e0b\u4ea7\u54c1Inlyta<span style=\"color: rgb(136, 136, 136);\">(Axitinib)<\/span><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\"><span style=\"color: rgb(62, 62, 62);font-size: 16px;text-align: center;background-color: rgb(255, 255, 255);\">\u8054\u7528\u4e8e\u4e00\u7ebf<\/span>\u665a\u671f\/\u8f6c\u79fb\u6027\u80be\u764c\u4e34\u5e8a\u8bd5\u9a8c<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u8fbe\u6210\u9996\u8981\u7814\u7a76\u7ec8\u70b9<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u5373OS&amp;PFS<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u6765\u81ea\u72ec\u7acb\u6570\u636e\u76d1\u6d4b\u59d4\u5458\u4f1a\u7684\u9996\u4e2a\u4e2d\u671f\u5206\u6790\u7ed3\u679c<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\"><br  \/><\/p>\n<section class=\"xmt-style-block\"   >\n<section class=\"KolEditor\" style=\"border-width: 0px;border-style: none;border-color: initial;padding: 0px;\">\n<section class=\"Powered-by-KolEditor V5\" style=\"box-sizing: border-box;\" >\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section class=\"\" style=\"padding-bottom: 1.2em;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;line-height: 1em;height: 1em;margin-top: -0.5em;box-sizing: border-box;\"><span style=\"display: inline-block;vertical-align: top;font-size: 80px;line-height: 1em;color: rgb(192, 200, 209);box-sizing: border-box;\">\u201c<\/span> <\/p>\n<section style=\"width: 4em;border-bottom: 1px solid rgb(192, 200, 209);display: inline-block;vertical-align: middle;margin-top: 1.6em;margin-left: -0.6em;box-sizing: border-box;\"><\/section>\n<\/section>\n<section class=\"\" style=\"margin-top: -0.5em;padding: 10px;box-sizing: border-box;\">\n<section class=\"Powered-by-KolEditor V5\" style=\"box-sizing: border-box;\" >\n<section class=\"\" style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"text-align: center;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;text-align: left;\"><span style=\"font-size: 14px;\">This marks the first time that combination treatment with an anti-PD-1 therapy has achieved the dual primary endpoints of overall survival and progression-free survival as first-line therapy in advanced renal cell carcinoma. We are very grateful to the investigators and patients for their involvement in this important study, the results of which will be filed with global regulatory authorities in the near future.<\/span><\/section>\n<section style=\"box-sizing: border-box;text-align: right;\"><strong><span style=\"color: rgb(62, 62, 62);background-color: rgb(255, 255, 255);font-size: 14px;\">\u2014\u2014 Dr. Roger M. Perlmutter<\/span><\/strong><\/section>\n<section style=\"box-sizing: border-box;text-align: right;\"><span style=\"background-color: rgb(255, 255, 255);font-size: 12px;color: rgb(136, 136, 136);\">President, Merck Research Laboratories<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;height: 1em;float: right;line-height: 1;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 4em;border-bottom: 1px solid rgb(192, 200, 209);box-sizing: border-box;\"><\/section>\n<\/section>\n<section style=\"display: inline-block;height: 1em;float: right;line-height: 1;box-sizing: border-box;\"><span style=\"display: inline-block;vertical-align: top;font-size: 80px;margin-top: -0.11em;margin-left: -0.1em;color: rgb(192, 200, 209);box-sizing: border-box;\">\u201d<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\"><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/0-1544158440.jpg\" alt=\"Pembrolizumab\u4e0eAxitinib\u8054\u7528\u4e8e\u4e00\u7ebf\u80be\u764c\u4e34\u5e8a\u8bd5\u9a8c\u8fbe\u6210\u9996\u8981\u7814\u7a76\u7ec8\u70b9\" title=\"Pembrolizumab\u4e0eAxitinib\u8054\u7528\u4e8e\u4e00\u7ebf\u80be\u764c\u4e34\u5e8a\u8bd5\u9a8c\u8fbe\u6210\u9996\u8981\u7814\u7a76\u7ec8\u70b9\"><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\"><br  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u8be5\u7814\u7a76\u4ee3\u53f7\u4e3aKEYNOTE-426<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u4e34\u5e8aIII\u671f\u8bd5\u9a8c<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u5171\u8ba1\u62db\u52df862\u4f4d\u53d7\u8bd5\u8005<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u8d77\u59cb\u4e8e2016.09.16<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u5bf9\u7167\u7ec4\u4e3a\u4e00\u7ebf\u6807\u51c6\u6cbb\u7597\u65b9\u6848<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\"><strong>Sunitinib\u5355\u836f<\/strong><\/p>\n<p style=\"color: rgb(62, 62, 62);font-size: 16px;white-space: normal;background-color: rgb(255, 255, 255);max-width: 100%;box-sizing: border-box;min-height: 1em;text-align: center;overflow-wrap: break-word !important;\">\u9996\u8981\u7814\u7a76\u7ec8\u70b9\u4e3aOS&amp;PFS<\/p>\n<p style=\"color: rgb(62, 62, 62);font-size: 16px;white-space: normal;background-color: rgb(255, 255, 255);max-width: 100%;box-sizing: border-box;min-height: 1em;text-align: center;overflow-wrap: break-word !important;\">\u6b21\u8981\u7814\u7a76\u7ec8\u70b9\u5305\u62ecORR\/DCR\u7b49<\/p>\n<p style=\"color: rgb(62, 62, 62);font-size: 16px;white-space: normal;background-color: rgb(255, 255, 255);max-width: 100%;box-sizing: border-box;min-height: 1em;text-align: center;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"color: rgb(62, 62, 62);font-size: 16px;white-space: normal;background-color: rgb(255, 255, 255);max-width: 100%;box-sizing: border-box;min-height: 1em;text-align: center;overflow-wrap: break-word !important;\"><img class=\"\"      src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/2-1544158441.jpg\" alt=\"Pembrolizumab\u4e0eAxitinib\u8054\u7528\u4e8e\u4e00\u7ebf\u80be\u764c\u4e34\u5e8a\u8bd5\u9a8c\u8fbe\u6210\u9996\u8981\u7814\u7a76\u7ec8\u70b9\" title=\"Pembrolizumab\u4e0eAxitinib\u8054\u7528\u4e8e\u4e00\u7ebf\u80be\u764c\u4e34\u5e8a\u8bd5\u9a8c\u8fbe\u6210\u9996\u8981\u7814\u7a76\u7ec8\u70b9\"><br  \/><\/p>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<p style=\"color: rgb(62, 62, 62);font-size: 16px;white-space: normal;background-color: rgb(255, 255, 255);max-width: 100%;box-sizing: border-box;min-height: 1em;text-align: center;overflow-wrap: break-word !important;\">PD-1\u6291\u5236\u5242\u5728RCC\u9886\u57df\u7684\u5e94\u7528<\/p>\n<p style=\"color: rgb(62, 62, 62);font-size: 16px;white-space: normal;background-color: rgb(255, 255, 255);max-width: 100%;box-sizing: border-box;min-height: 1em;text-align: center;overflow-wrap: break-word !important;\">\u5df2\u7ecf\u6709\u4e24\u79cd\u6cbb\u7597\u65b9\u6848\u83b7\u6279<\/p>\n<p style=\"color: rgb(62, 62, 62);font-size: 16px;white-space: normal;background-color: rgb(255, 255, 255);max-width: 100%;box-sizing: border-box;min-height: 1em;text-align: center;overflow-wrap: break-word !important;\"><strong><span style=\"color: rgb(0, 122, 170);\">Opdivo\u5355\u836f\u4e8c\u7ebf\u65b9\u6848<\/span><\/strong><\/p>\n<p style=\"color: rgb(62, 62, 62);font-size: 16px;white-space: normal;background-color: rgb(255, 255, 255);max-width: 100%;box-sizing: border-box;min-height: 1em;text-align: center;overflow-wrap: break-word !important;\"><strong><span style=\"color: rgb(0, 122, 170);\">Opdvio+Yervoy\u4e00\u7ebf\u65b9\u6848<\/span><\/strong><\/p>\n<p style=\"color: rgb(62, 62, 62);font-size: 16px;white-space: normal;background-color: rgb(255, 255, 255);max-width: 100%;box-sizing: border-box;min-height: 1em;text-align: center;overflow-wrap: break-word !important;\">\u540c\u65f6<\/p>\n<p style=\"color: rgb(62, 62, 62);font-size: 16px;white-space: normal;background-color: rgb(255, 255, 255);max-width: 100%;box-sizing: border-box;min-height: 1em;text-align: center;overflow-wrap: break-word !important;\">\u8fd8\u6709\u4e0a\u6708\u53d1\u5e03\u7ed3\u679c\u7684Pfizer\u6cbb\u7597\u65b9\u6848<\/p>\n<p style=\"color: rgb(62, 62, 62);font-size: 16px;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;\">Bavencio+Inlyta<\/p>\n<p style=\"color: rgb(62, 62, 62);font-size: 16px;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;\">\u8be5<span style=\"color: rgb(62, 62, 62);font-size: 16px;text-align: center;background-color: rgb(255, 255, 255);\">\u4e34\u5e8a\u4ee3\u53f7<\/span>Javelin renal 101<\/p>\n<p style=\"color: rgb(62, 62, 62);font-size: 16px;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;\">\u540c\u6837\u4e0e\u6807\u51c6\u7597\u6cd5Sunitinib\u5355\u836f\u5bf9\u6bd4<\/p>\n<p style=\"color: rgb(62, 62, 62);font-size: 16px;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;\">PFS\u7684\u5ef6\u957f\u663e\u793a\u51fa\u7edf\u8ba1\u5b66\u610f\u4e49<\/p>\n<p style=\"color: rgb(62, 62, 62);font-size: 16px;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;\">\u5e76\u4e8e\u4eca\u5e74\u521d\u83b7FDA\u7a81\u7834\u6027\u7597\u6cd5\u79f0\u53f7<\/p>\n<p style=\"text-align: center;\">\u518d\u540c\u65f6<br  \/><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">MSD\u65d7\u4e0bKeytruda\u4e0eEisai\u7684Lenvima<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u7528\u4e8e\u665a\u671f\u80be\u7ec6\u80de\u764c\u65b9\u6848<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u4e5f\u5df2\u83b7\u5f97FDA\u7a81\u7834\u6027\u7597\u6cd5\u79f0\u53f7<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u53e6\u5916<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u8fd8\u6709Exelixis\u5f00\u5c55\u7684<span style=\"color: rgb(62, 62, 62);font-size: 16px;text-align: center;background-color: rgb(255, 255, 255);\">III\u671f<\/span>\u4e34\u5e8a<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">Opdivo+Cbometyx<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u4e5f\u6709\u671b\u5728\u660e\u5e74\u51fa\u7089\u76f8\u5173\u7ed3\u679c<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\"><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/0-1544158441.jpg\" alt=\"Pembrolizumab\u4e0eAxitinib\u8054\u7528\u4e8e\u4e00\u7ebf\u80be\u764c\u4e34\u5e8a\u8bd5\u9a8c\u8fbe\u6210\u9996\u8981\u7814\u7a76\u7ec8\u70b9\" title=\"Pembrolizumab\u4e0eAxitinib\u8054\u7528\u4e8e\u4e00\u7ebf\u80be\u764c\u4e34\u5e8a\u8bd5\u9a8c\u8fbe\u6210\u9996\u8981\u7814\u7a76\u7ec8\u70b9\"><\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\"><br  \/><\/p>\n<section class=\"xmt-style-block\"   >\n<section class=\"KolEditor\" style=\"border-width: 0px;border-style: none;border-color: initial;padding: 0px;\">\n<section class=\"Powered-by-KolEditor V5\" style=\"box-sizing: border-box;\" >\n<section class=\"\" style=\"margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section class=\"\" style=\"padding-bottom: 1.2em;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;line-height: 1em;height: 1em;margin-top: -0.5em;box-sizing: border-box;\"><span style=\"display: inline-block;vertical-align: top;font-size: 80px;line-height: 1em;color: rgb(192, 200, 209);box-sizing: border-box;\">\u201c<\/span> <\/p>\n<section style=\"width: 4em;border-bottom: 1px solid rgb(192, 200, 209);display: inline-block;vertical-align: middle;margin-top: 1.6em;margin-left: -0.6em;box-sizing: border-box;\"><\/section>\n<\/section>\n<section class=\"\" style=\"margin-top: -0.5em;padding: 10px;box-sizing: border-box;\">\n<section class=\"Powered-by-KolEditor V5\" style=\"box-sizing: border-box;\" >\n<section class=\"\" style=\"box-sizing: border-box;\">\n<section class=\"\" style=\"text-align: center;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;text-align: left;\"><span style=\"font-size: 14px;\">PD-1s work with Pfizer\u2019s Inlyta in RCC. We learned that w\/ Pfizer\u2019s Bavencio (PFS) and today w\/ Merck\u2019s Keytruda (PFS &amp; OS).&nbsp;<\/span><\/section>\n<section style=\"box-sizing: border-box;text-align: left;\"><span style=\"font-size: 14px;\">In the future <strong>Pfizer should offer a discount for the entire combo using their two drugs and cut Merck out.<\/strong> That\u2019s where this should be headed one day IMO.<\/span><\/section>\n<section style=\"box-sizing: border-box;text-align: right;\"><strong><span style=\"font-size: 14px;\">\u2014\u2014Brad Loncar<\/span><\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;height: 1em;float: right;line-height: 1;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 4em;border-bottom: 1px solid rgb(192, 200, 209);box-sizing: border-box;\"><\/section>\n<p><span style=\"display: inline-block;vertical-align: top;font-size: 80px;margin-top: -0.11em;margin-left: -0.1em;color: rgb(192, 200, 209);box-sizing: border-box;\">\u201d<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u8be5\u65b9\u6848MSD\u6700\u7ec8\u5c06\u9762\u4e34\u7684\u95ee\u9898<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u5927\u6982\u7387\u5982Brad\u6240\u8ff0<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">Pfizer\u8c03\u4f4eAxitinib+Avelumab\u4ef7\u683c<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">Keytruda\u8054\u7528\u65b9\u6848\u5c06\u5931\u53bb\u4ef7\u683c\u4f18\u52bf<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u5e02\u573a\u7ade\u4e89\u529b\u5c06\u4f1a\u964d\u4f4e<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u4e0d\u8fc7<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">MSD\u8fd8\u6709\u8001\u4f19\u8ba1Eisai<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u5373\u4e0e\u4e50\u4f10\u66ff\u5c3c\u7684\u8054\u7528\u65b9\u6848<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: center;\">\u5982\u679c\u80fd\u4ee5\u4e0d\u9519\u7684\u7ed3\u679c\u83b7\u6279\u4e0a\u5e02<\/p>\n<p style=\"max-width: 100%;box-sizing: border-box;min-height: 1em;word-wrap: break-word !important;text-align: 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