{"id":71429,"date":"2018-12-04T01:00:00","date_gmt":"2018-12-07T04:55:48","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/cebb4b0fc3\/"},"modified":"2018-12-07T12:55:49","modified_gmt":"2018-12-07T04:55:49","slug":"cebb4b0fc3","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/71429\/","title":{"rendered":"GSK\u51fa\u624b\u6570\u767e\u4ebf\u5e76\u8d2d\uff01\u52a0\u5165\u963f\u65af\u5229\u5eb7\u3001\u8f89\u745e\u6218\u5c40"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"text-align: center;\"><img class=\"__bg_gif\"         width=\"auto\" style=\"text-align: center;white-space: normal;color: rgb(62, 62, 62);font-family: \u5fae\u8f6f\u96c5\u9ed1;z-index: -1;cursor: pointer;font-size: 14px;line-height: 22.4px;background-color: rgb(255, 255, 255);width: 558px;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/2-1544158548.jpeg\" alt=\"GSK\u51fa\u624b\u6570\u767e\u4ebf\u5e76\u8d2d\uff01\u52a0\u5165\u963f\u65af\u5229\u5eb7\u3001\u8f89\u745e\u6218\u5c40\" title=\"GSK\u51fa\u624b\u6570\u767e\u4ebf\u5e76\u8d2d\uff01\u52a0\u5165\u963f\u65af\u5229\u5eb7\u3001\u8f89\u745e\u6218\u5c40\"  \/><\/p>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<p>\u3000\u3000\u751f\u7269\u6280\u672f\u4f01\u4e1aTesaro\u4e00\u76f4\u5728\u5bfb\u627e\u51fa\u552e\u673a\u4f1a\uff0c\u5982\u4eca\u7ec8\u4e8e\u7b49\u6765\u4e86\u5927\u4e70\u5bb6\u2014\u2014\u91cd\u56de\u6297\u80bf\u7624\u9886\u57df\u7684\u845b\u5170\u7d20\u53f2\u514b\uff08GSK\uff09\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000GSK\u5df2\u540c\u610f\u4ee551\u4ebf\u7f8e\u5143\uff08\u7ea6349\u4ebf\u5143\u4eba\u6c11\u5e01\uff09\u6536\u8d2dTesaro\uff0c\u540e\u8005\u7684\u4e3b\u6253\u4ea7\u54c1\u662fPARP\u6291\u5236\u5242Zejula\uff0c\u8fd8\u6709\u53e6\u59163\u4e2a\u5904\u4e8e\u4e34\u5e8a\u9636\u6bb5\u7684\u5728\u7814\u6297\u80bf\u7624\u836f\u7269\u3002<\/p>\n<p>\u3000\u3000\u3000\u3000<\/p>\n<section class=\"_135editor\"     style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"135brush\" style=\"border-left: 5px solid #ef7060;font-weight: bold;line-height: 32px;color: #666666;padding: 5px 10px;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<p style=\"line-height: 1.5em;\"><strong style=\"caret-color: red;\"><span style=\"color: #ef7060;font-size: 18px;\">PARP\u6291\u5236\u5242\u5e02\u573a\u7a81\u56f4<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<p>\u3000\u3000<br  \/><\/p>\n<p>\u3000\u3000\u4e8b\u5b9e\u4e0a\uff0cPARP\u6291\u5236\u5242\u5e02\u573a\u5df2\u7ecf\u9010\u6e10\u62e5\u6324\uff0c\u76ee\u524d\u5df2\u67094\u4e2a\u4ea7\u54c1\u4e0a\u5e02\u3002\u9664\u4e86\u963f\u65af\u5229\u5eb7\uff08AstraZeneca\uff09\u7387\u5148\u83b7\u6279\u7684Lynparza\u4e0eClovis Oncology\u516c\u53f8\u7684Rubraca\uff0cZejula\u8fd8\u5c06\u9762\u4e34\u8f89\u745e\uff08Pfizer\uff09\u6700\u65b0\u83b7\u6279\u7684Talzenna\u7684\u7ade\u4e89\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u4eca\u5e74\u7b2c\u4e09\u5b63\u5ea6\uff0c\u4f5c\u4e3a\u5375\u5de2\u764c\u7684\u4e8c\u7ebf\u7ef4\u6301\u7597\u6cd5\uff0cZejula\u83b7\u5f97\u4e866300\u4e07\u7f8e\u5143\u7684\u9500\u552e\u989d\uff0c\u8f83\u7b2c\u4e8c\u5b63\u5ea6\u76845400\u4e07\u7f8e\u5143\u6709\u6240\u589e\u52a0\uff0c\u4f46\u4ecd\u8fdc\u4e0d\u53ca\u5feb\u901f\u589e\u957f\u7684Lynparza\u5728\u7b2c\u4e09\u5b63\u5ea6\u521b\u4e0b\u76841.69\u4ebf\u7f8e\u5143\u9500\u552e\u989d\uff08\u524d\u4e09\u5b63\u5ea6\u603b\u9500\u552e\u989d\u8fbe4.38\u4ebf\u7f8e\u5143\uff09\u3002Lynparza\u65b0\u8fd1\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u4e73\u817a\u764c\uff0c\u9500\u552e\u989d\u8fd8\u4f1a\u8d70\u9ad8\u3002Rubraca\u4eca\u5e74\u7b2c\u4e09\u5b63\u5ea6\u7684\u9500\u552e\u989d\u7ea6\u4e3a2300\u4e07\u7f8e\u5143\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u5206\u6790\u5e08\u9884\u6d4b\uff0cZejula\u4eca\u5e74\u5168\u5e74\u7684\u9500\u552e\u989d\u6709\u671b\u8fbe\u52302.4\u4ebf\u7f8e\u5143\uff0c\u52302023\u5e74\u8de8\u516510\u4ebf\u7f8e\u5143\u95e8\u69db\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u4e8b\u5b9e\u4e0a\uff0cGSK\u5bf9\u4e8e\u6b64\u6b21\u6536\u8d2d\u6bcf\u80a1\u652f\u4ed8\u7684\u4ef7\u683c\u4e3a75\u7f8e\u5143\uff0c\u6bd4Tesaro\u8fd130\u5929\u7684\u5e73\u5747\u4ef7\u683c\u9ad8\u51fa110\uff05\u3002\u6b64\u5916\uff0c\u5176\u8fd8\u627f\u62c5\u4e86\u540e\u8005\u7684\u503a\u52a1\u3002\u4e1a\u754c\u666e\u904d\u8ba4\u4e3aGSK\u6b64\u6b21\u6536\u8d2d\u5bf9Tesaro\u7684\u4f30\u503c\u8fc7\u9ad8\uff0c\u5e76\u8d2d\u6d88\u606f\u4f20\u51fa\uff0cGSK\u80a1\u4ef7\u4e0b\u8dcc7\uff05\uff0c\u4e3a\u8fd1\u5341\u5e74\u5355\u65e5\u6700\u5927\u8dcc\u5e45\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u4e0d\u8fc7\uff0c\u5728GSK\u7814\u53d1\u90e8\u95e8\u4e3b\u7ba1Hal Barron\u770b\u6765\uff0cPARP\u6291\u5236\u5242\u7684\u91cd\u8981\u6027\u6bd4\u5f53\u524d\u5c55\u73b0\u51fa\u6765\u7684\u8981\u5927\uff0cZejula\u8fd8\u6709\u66f4\u591a\u7684\u5546\u4e1a\u6f5c\u529b\u5f85\u6316\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000GSK\u4e0d\u53ea\u662f\u76ef\u7740BRCA\u7a81\u53d8\uff08\u643a\u5e26BRCA\u7a81\u53d8\u7684\u80bf\u7624\u7ec6\u80de\u5bf9PARP\u6291\u5236\u5242\u7684\u654f\u611f\u5ea6\u9ad8\uff09\uff0c\u4e5f\u60f3\u5728\u5375\u5de2\u764c\u4e4b\u5916\u627e\u5230\u673a\u4f1a\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000Zejula\u6b63\u5728\u8fdb\u884c\u76f8\u5173\u8bd5\u9a8c\uff0c\u8bc4\u4f30\u5176\u5bf9\u4e8e\u540c\u6e90\u91cd\u7ec4\u7f3a\u9677\uff08HRD\uff09\u5375\u5de2\u764c\u60a3\u8005\u7684\u6cbb\u7597\u6548\u679c\u3002Barron\u8868\u793a\uff0c\u53ea\u670915%\u7684\u5375\u5de2\u764c\u60a3\u8005\u8868\u8fbeBRCA\u7a81\u53d8\uff0c\u800c\u591a\u8fbe50%\u60a3\u8005\u663e\u793a\u51faHRD\u7684\u8ff9\u8c61\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u6b64\u5916\uff0cZejula\u4e5f\u5f00\u5c55\u4e86\u9488\u5bf9\u80ba\u764c\u3001\u4e73\u817a\u764c\u4e0e\u524d\u5217\u817a\u764c\u7684\u76f8\u5173\u8bd5\u9a8c\uff0c\u65e2\u6709\u5355\u4e00\u7597\u6cd5\u4e5f\u6709\u8054\u5408\u7597\u6cd5\uff0c\u5176\u4e2d\u8fd8\u5305\u62ec\u4e0eTesaro\u81ea\u4e3b\u7814\u53d1\u7684PD-1\u6297\u4f53dostarlimab\u7684\u8054\u7528\u8bd5\u9a8c\u3002\u201cZejula\u5c06\u8bc1\u660e\u5176\u53ef\u4ee5\u4f5c\u4e3a\u4e00\u7ebf\u7597\u6cd5\u8ba9BRCA\u7a81\u53d8\u4e4b\u5916\u7684\u5375\u5de2\u764c\u60a3\u8005\u4e5f\u83b7\u76ca\uff0c\u6211\u4eec\u5bf9\u6b64\u5341\u5206\u4e50\u89c2\u3002\u201dBarron\u8868\u793a\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u800c\u4e3a\u4e86\u786e\u4fddZejula\u7684\u6269\u5927\u5e94\u7528\u8ba1\u5212\u80fd\u591f\u594f\u6548\uff0cGSK\u9700\u8981\u8bc6\u522b\u51fa\u5408\u9002\u7684\u60a3\u8005\u3002\u5df2\u4e0e\u5176\u5efa\u7acb\u5408\u4f5c\u5173\u7cfb\u7684\u57fa\u56e0\u68c0\u6d4b\u516c\u53f823andMe\u5c06\u5927\u6709\u7528\u573a\uff0c\u53ef\u4ee5\u901a\u8fc7\u6df1\u6316\u9057\u4f20\u673a\u5236\u5e2e\u52a9GSK\u4f18\u5316\u7814\u53d1\u7ebf\u3002<\/p>\n<p>\u3000\u3000\u3000\u3000<\/p>\n<section class=\"_135editor\"     style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"135brush\" style=\"border-left: 5px solid #ef7060;font-weight: bold;line-height: 32px;color: #666666;padding: 5px 10px;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<p style=\"line-height: 1.5em;\"><strong style=\"caret-color: red;\"><span style=\"color: #ef7060;font-size: 18px;\">\u91cd\u6784\u6297\u80bf\u7624\u4e1a\u52a1<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<p>\u3000\u3000<br  \/><\/p>\n<p>\u3000\u3000\u81ea2017\u5e74\u63a5\u8fc7\u5e05\u4f4d\u4ee5\u6765\uff0cGSK\u9996\u5e2d\u6267\u884c\u5b98Emma Walmsley\u5c31\u5bf9\u8be5\u516c\u53f8\u7684\u7814\u53d1\u4e1a\u52a1\u8fdb\u884c\u4e86\u5f7b\u5e95\u8c03\u6574\uff0c\u5e76\u629b\u51fa\u4e00\u9879\u5305\u62ec\u91cd\u65b0\u805a\u7126\u6297\u80bf\u7624\u9886\u57df\u7684\u8ba1\u5212\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u57282014\u5e74\u7684\u4e09\u65b9\u8d44\u4ea7\u7f6e\u6362\u4ea4\u6613\u4e2d\uff0cGSK\u5c06\u5176\u80bf\u7624\u4e1a\u52a1\u6574\u4f53\u51fa\u552e\u7ed9\u8bfa\u534e\uff08Novartis\uff09\uff0c\u6b64\u540e\u8be5\u516c\u53f8\u5c31\u6ca1\u6709\u6297\u80bf\u7624\u836f\u7684\u9500\u552e\u56e2\u961f\u3002\u800c\u5982\u4eca\uff0cGSK\u6700\u5177\u524d\u666f\u7684\u5728\u7814\u6297\u764c\u836f\u662fBCMA\u6297\u4f53GSK2857916\uff0c\u8be5\u836f\u5df2\u5728\u4eca\u5e747\u6708\u5f00\u59cb\u8fdb\u884c\u9488\u5bf9\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u3002\u5728\u300a\u5236\u836f\u884c\u4e1a2018\u5c55\u671b\u300b\u62a5\u544a\u4e2d\uff0cEvaluate Pharma\u516c\u53f8\u5c06GSK2857916\u5217\u4e3a\u4ef7\u503c\u6700\u9ad8\u7684\u4e94\u5927\u7814\u53d1\u9879\u76ee\u4e4b\u4e00\uff0c\u9884\u6d4b\u5176\u52302024\u5e74\u9500\u552e\u989d\u53ef\u8fbe13.7\u4ebf\u7f8e\u5143\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u5bf9Tesaro\u7684\u6536\u8d2d\u5c06\u76f4\u63a5\u4e3aGSK\u5728\u80bf\u7624\u4e1a\u52a1\u4e0a\u7684\u5546\u4e1a\u57fa\u7840\u5e26\u6765\u53d8\u5316\uff0c\u540c\u65f6\u4e5f\u5f3a\u5316\u4e86\u5176\u6297\u80bf\u7624\u7814\u53d1\u7ebf\u3002\u4e8b\u5b9e\u4e0a\uff0cGSK\u80bf\u7624\u90e8\u95e8\u8d1f\u8d23\u4ebaAxel Hoos\u4e00\u4e2a\u6708\u524d\u5728\u63a5\u53d7\u91c7\u8bbf\u65f6\u5c31\u8868\u793a\uff0c\u8be5\u516c\u53f8\u53ef\u80fd\u4f1a\u628a\u7814\u53d1\u5de5\u4f5c\u4ece\u5176\u957f\u671f\u4f5c\u4e3a\u652f\u67f1\u677f\u5757\u7684\u547c\u5438\u7cfb\u7edf\u6cbb\u7597\u9886\u57df\u4e2d\u64a4\u51fa\uff0c\u8fdb\u4e00\u6b65\u52a0\u7801\u524d\u666f\u66f4\u770b\u597d\u7684\u6297\u80bf\u7624\u9886\u57df\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u4ece\u547c\u5438\u7cfb\u7edf\u6cbb\u7597\u9886\u57df\u9010\u6e10\u9000\u573a\uff0c\u6b63\u662fWalmsley\u53bb\u5e74\u629b\u51fa\u7684\u91cd\u7ec4\u8ba1\u5212\u4e2d\u7684\u4e00\u5927\u8f6c\u53d8\uff0c\u8fd9\u4e5f\u53cd\u6620\u4e86\u76f8\u5173\u4ea7\u54c1\u8fd1\u6765\u7684\u8870\u9000\u3002\u4eca\u5e74\u7b2c\u4e09\u5b63\u5ea6\uff0c\u5c3d\u7ba1\u8f83\u65b0\u7684Nucala \u4e0eTrelegy\u589e\u957f\u5f3a\u52b2\uff0c\u4f46GSK\u547c\u5438\u7cfb\u7edf\u4ea7\u54c1\u7684\u6574\u4f53\u9500\u552e\u4f9d\u65e7\u8868\u73b0\u5e73\u5e73\uff0c\u8fd9\u4e5f\u8ba9\u4eff\u5236\u836f\u6b65\u6b65\u8fd1\u903c\u7684\u201c\u91cd\u78c5\u70b8\u5f39\u201dAdvair\u627f\u53d7\u4e86\u66f4\u5927\u538b\u529b\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u201c\u957f\u65f6\u95f4\u4ee5\u6765\uff0c\u547c\u5438\u7cfb\u7edf\u6cbb\u7597\u9886\u57df\u662fGSK\u836f\u7269\u7814\u53d1\u7684\u9a71\u52a8\u529b\uff0c\u6211\u4eec\u4e5f\u5728\u8be5\u9886\u57df\u53d6\u5f97\u4e86\u5de8\u5927\u6210\u529f\u3002\u4f46\u5982\u4eca\uff0c\u8fd9\u9879\u4e1a\u52a1\u5df2\u76f8\u5f53\u5e73\u7a33\uff0c\u672a\u6765\u5e76\u6ca1\u6709\u592a\u5927\u7684\u589e\u957f\u9884\u671f\u3002\u201d Hoos\u8868\u793a\u3002<\/p>\n<p style=\"text-align: left;\"><br  \/><\/p>\n<p style=\"white-space: normal;\"><strong style=\"color: rgb(62, 62, 62);font-size: 16px;max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(79, 129, 189);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u25a0\u7f16\u8bd1 \u9648\u96ea\u8587<\/span><\/strong><\/p>\n<p style=\"white-space: normal;\"><strong style=\"color: rgb(62, 62, 62);font-size: 16px;max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(79, 129, 189);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"font-size: 16px;white-space: normal;color: rgb(62, 62, 62);max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(79, 129, 189);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u25a0\u6765\u6e90 FiercePharma<\/span><\/strong><\/span><\/strong><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: center;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/0-1544158549.jpeg\" alt=\"GSK\u51fa\u624b\u6570\u767e\u4ebf\u5e76\u8d2d\uff01\u52a0\u5165\u963f\u65af\u5229\u5eb7\u3001\u8f89\u745e\u6218\u5c40\" title=\"GSK\u51fa\u624b\u6570\u767e\u4ebf\u5e76\u8d2d\uff01\u52a0\u5165\u963f\u65af\u5229\u5eb7\u3001\u8f89\u745e\u6218\u5c40\"  \/><\/p>\n<p style=\"white-space: normal;text-align: center;\"><strong style=\"color: rgb(62, 62, 62);font-size: 16px;max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(79, 129, 189);font-family: \u5b8b\u4f53;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/span><\/strong><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u3000\u3000\u751f\u7269\u6280\u672f\u4f01\u4e1aTesaro\u4e00\u76f4\u5728\u5bfb\u627e\u51fa\u552e\u673a\u4f1a\uff0c\u5982\u4eca\u7ec8\u4e8e\u7b49\u6765\u4e86\u5927\u4e70\u5bb6\u2014\u2014\u91cd\u56de\u6297\u80bf\u7624\u9886\u57df\u7684\u845b\u5170\u7d20\u53f2\u514b\uff08GSK\uff09\u3002 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