{"id":71710,"date":"2018-11-26T01:00:00","date_gmt":"2018-12-07T04:58:12","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/3ff4b8eff5\/"},"modified":"2018-12-07T12:58:18","modified_gmt":"2018-12-07T04:58:18","slug":"3ff4b8eff5","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/71710\/","title":{"rendered":"\u4e09\u95ee\u4eba\u7c7b\u80da\u80ce\u57fa\u56e0\u7f16\u8f91\u201c\u4f26\u7406\u95e8\u201d"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"text-align: center;\"><img class=\"__bg_gif\"         width=\"auto\" style=\"text-align: center;white-space: normal;color: rgb(62, 62, 62);font-family: \u5fae\u8f6f\u96c5\u9ed1;z-index: -1;cursor: pointer;font-size: 14px;line-height: 22.4px;background-color: rgb(255, 255, 255);width: 558px;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/4-1544158693.jpeg\" alt=\"\u4e09\u95ee\u4eba\u7c7b\u80da\u80ce\u57fa\u56e0\u7f16\u8f91\u201c\u4f26\u7406\u95e8\u201d\" title=\"\u4e09\u95ee\u4eba\u7c7b\u80da\u80ce\u57fa\u56e0\u7f16\u8f91\u201c\u4f26\u7406\u95e8\u201d\"  \/><\/p>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<p>\u3000\u3000\u6628\u5929\uff0c\u6765\u81ea\u4e2d\u56fd\u6df1\u5733\u7684\u8d3a\u5efa\u594e\u526f\u6559\u6388\u5728\u7b2c\u4e8c\u5c4a\u56fd\u9645\u4eba\u7c7b\u57fa\u56e0\u7ec4\u7f16\u8f91\u5cf0\u4f1a\u53ec\u5f00\u524d\u4e00\u5929\u5ba3\u5e03\uff0c\u4e00\u5bf9\u540d\u4e3a\u201c\u9732\u9732\u201d\u548c\u201c\u5a1c\u5a1c\u201d\u7684\u57fa\u56e0\u7f16\u8f91\u5a74\u513f\u4e8e11\u6708\u5728\u4e2d\u56fd\u8bde\u751f\u4e86\u3002\u8fd9\u5728\u5168\u4e16\u754c\u6295\u4e0b\u4e86\u4e00\u9897\u201c\u6df1\u6c34\u70b8\u5f39\u201d\uff0c\u6fc0\u8d77\u4e86\u4e2d\u56fd\u548c\u4e16\u754c\u5404\u56fd\u79d1\u5b66\u5bb6\u4eec\u6d77\u5578\u822c\u7684\u8ba8\u8bba\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u8fd9\u6837\u4e00\u4e2a\u5f88\u53ef\u80fd\u662f\u4eba\u7c7b\u533b\u5b66\u5386\u53f2\u4e0a\u6700\u4e3a\u91cd\u8981\u7684\u91cc\u7a0b\u7891\u4e4b\u4e00\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5374\u5728\u5f00\u59cb\u4e4b\u524d\u3001\u8fdb\u884c\u4e4b\u4e2d\u4ece\u672a\u89c1\u6709\u4efb\u4f55\u62a5\u9053\u548c\u8ba8\u8bba\uff0c\u66f4\u6ca1\u6709\u770b\u5230\u4efb\u4f55\u4e25\u8083\u7684\u79d1\u5b66\u8bba\u6587\u3002\u5c31\u50cf\u201c\u653e\u536b\u661f\u201d\u4e00\u6837\u8f7b\u7387\u5730\u901a\u8fc7\u65b0\u5a92\u4f53\u6765\u62a5\u9053\u3002\u5e76\u4e14\uff0c\u5728\u6ca1\u6709\u6743\u5a01\u4e13\u5bb6\u9274\u5b9a\u7684\u60c5\u51b5\u4e0b\uff0c\u81ea\u884c\u5ba3\u5e03\u65b0\u751f\u5a74\u513f\u5747\u4e3a\u201c\u5065\u5eb7\u201d\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u8fd9\u8ba9\u5168\u4e16\u754c\u4e25\u8083\u7684\u79d1\u5b66\u7814\u7a76\u4eba\u5458\u4eec\u5927\u5403\u4e00\u60ca\u3002\u901a\u8fc7\u57fa\u56e0\u6280\u672f\u6765\u4fee\u6539\u4eba\u7c7b\u57fa\u56e0\uff0c\u9664\u4e86\u6280\u672f\u672c\u8eab\u7684\u5148\u8fdb\u6027\u548c\u5b89\u5168\u6027\u5916\uff0c\u4e5f\u662f\u4e00\u4e2a\u9700\u8981\u4e25\u8083\u5bf9\u5f85\u7684\u793e\u4f1a\u4f26\u7406\u95ee\u9898\u3002\u9664\u4e86\u79d1\u5b66\u754c\u4e3a\u6b64\u9707\u60ca\u5916\uff0c\u66f4\u91cd\u8981\u7684\u662f\u8fd9\u4e00\u5bf9\u672c\u6765\u5177\u6709\u201c\u5065\u5eb7\u57fa\u56e0\u201d\u7684\u5b69\u5b50\u56e0\u4e3a\u4e00\u4e2a\u4e0d\u6210\u719f\u7684\u7406\u8bba\u548c\u6280\u672f\u53d8\u5f97\u201c\u547d\u8fd0\u582a\u5fe7\u201d\u3002\u56e0\u6b64\uff0c\u53ef\u4ee5\u628a\u8fd9\u4e2a\u4e8b\u4ef6\u79f0\u4f5c\u57fa\u56e0\u7f16\u8f91\u5386\u53f2\u4e0a\u7684\u201c\u4f26\u7406\u95e8\u201d\u3002<\/p>\n<p>\u3000\u3000\u3000\u3000<\/p>\n<section class=\"_135editor\"    style=\"font-size: 16px;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;padding-right: 3px;padding-left: 3px;box-sizing: border-box;\">\n<section style=\"width: 6px;height: 6px;margin-left: -3px;border-radius: 100%;color: rgb(255, 255, 255);background-color: rgb(239, 112, 96);box-sizing: border-box;\"><\/section>\n<section style=\"border-left: 1px solid #ef7060;box-sizing: border-box;\">\n<section style=\"padding: 3px 10px;box-sizing: border-box;\">\n<section class=\"135brush\"  style=\"box-sizing: border-box;\"><span style=\"color: #ef7060;font-size: 18px;\"><strong>\u8d28\u75911\uff1a<\/strong><\/span><\/section>\n<\/section>\n<\/section>\n<section style=\"border-top: 1px solid rgb(239, 112, 96);width: 100%;float: left;box-sizing: border-box;\" ><\/section>\n<section style=\"width: 6px;height: 6px;margin-top: -4px;border-radius: 100%;float: right;color: rgb(255, 255, 255);background-color: rgb(239, 112, 96);box-sizing: border-box;\"><\/section>\n<section style=\"border-left: 1px solid rgb(239, 112, 96);box-sizing: border-box;\" class=\"135brush\">\n<section style=\"padding: 3px 10px;box-sizing: border-box;\">\n<p style=\"white-space: normal;\"><span style=\"color: #4f81bd;font-size: 18px;\">\u5728\u4eba\u7c7b\u80da\u80ce\u4e0a\u8fdb\u884c\u57fa\u56e0\u7f16\u8f91\u4e3a\u65f6\u5c1a\u65e9<\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"width: 6px;height: 6px;margin-left: -3px;border-radius: 100%;color: rgb(255, 255, 255);background-color: rgb(239, 112, 96);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<p>\u3000\u3000\u3000<\/p>\n<p>\u3000\u3000\u4eba\u7c7b\u57fa\u56e0\u7ec4\u672c\u8eab\u5f88\u53ef\u80fd\u5e76\u975e\u662f\u4e00\u4e2a\u5b8c\u7f8e\u7684\u4f53\u7cfb\u3002\u800c\u5177\u4f53\u5230\u6bcf\u4e2a\u4eba\u7684\u57fa\u56e0\u7ec4\uff0c\u5219\u66f4\u52a0\u53ef\u80fd\u5e26\u6709\u5404\u79cd\u81f4\u75c5\u57fa\u56e0\u3002\u56e0\u6b64\uff0c\u5728\u6253\u5f00\u57fa\u56e0\u7684\u5bc6\u7801\u540e\uff0c\u901a\u8fc7\u57fa\u56e0\u4fee\u9970\u7684\u65b9\u6cd5\u6765\u6d88\u9664\u75be\u75c5\u9690\u60a3\uff0c\u8fbe\u5230\u5065\u5eb7\u957f\u5bff\u7684\u76ee\u7684\uff0c\u4ece\u539f\u7406\u4e0a\u8bb2\u662f\u53ef\uff0c\u5e76\u4e14\u4e5f\u5e94\u8be5\u662f\u751f\u547d\u79d1\u5b66\u754c\u52aa\u529b\u7684\u4e00\u4e2a\u65b9\u5411\u3002\u4f46\u662f\uff0c\u79d1\u5b66\u754c\u76ee\u524d\u7684\u5171\u8bc6\u8ba4\u4e3a\uff0c\u76ee\u524d\u7684\u6280\u672f\uff0c\u5305\u62ec\u6700\u4e3a\u5148\u8fdb\u7684CRISPR\u6280\u672f\u90fd\u4e0d\u80fd\u4fdd\u8bc1\u51c6\u786e\u65e0\u8bef\u5730\u8fdb\u884c\u5fc5\u8981\u7684\u57fa\u56e0\u7f16\u8f91\u3002\u56e0\u6b64\u5728\u4eba\u7c7b\u80da\u80ce\u4e0a\u8fdb\u884c\u57fa\u56e0\u7f16\u8f91\u4e3a\u65f6\u5c1a\u65e9\u3002\u800c\u8fd9\u4e00\u70b9\uff0c\u8d3a\u6559\u6388\u672c\u4eba\u5e94\u8be5\u662f\u975e\u5e38\u6e05\u695a\u7684\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u30002017\u5e742\u6708\uff0c\u8d3a\u6559\u6388\u53c2\u52a0\u4e86\u4e00\u6b21\u56fd\u9645\u6027\u7684\u7814\u8ba8\u4f1a\uff08\u636e\u8d3a\u6559\u6388\u79f0\u8fd9\u6b21\u4f1a\u8bae\u662f\u95ed\u95e8\u4f1a\u8bae\uff09\u3002\u4f46\u662f\u4f1a\u540e\uff0c\u8d3a\u6559\u6388\u8fd8\u662f\u5728\u4ed6\u7684\u535a\u5ba2\u91cc\u516c\u5f00\u4e86\u81ea\u5df1\u7684\u610f\u89c1 \uff08http:\/\/blog.sciencenet.cn\/home.php?mod=space&amp;uid=514529&amp;do=blog&amp;id=1034671\uff09\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u5728\u8fd9\u7bc7\u79d1\u5b66\u7f51\u7684\u535a\u5ba2\u91cc\uff0c \u8d3a\u6559\u6388\u91cd\u70b9\u8c08\u4e86\u4eba\u7c7b\u80da\u80ce\u57fa\u56e0\u7f16\u8f91\u7684\u5b89\u5168\u6027\u95ee\u9898\u3002\u5176\u4e2d\u4e00\u4e2a\u91cd\u70b9\u5c31\u662f\u79d1\u5b66\u754c\u4e00\u76f4\u975e\u5e38\u5173\u6ce8\u7684CRISPR\u7684\u201c\u8131\u9776\u201d\uff08Off-Target\uff09\u95ee\u9898\u3002\u5bf9\u4e8e\u8fd9\u4e2a\u95ee\u9898\uff0c\u867d\u7136\u6709\u4eba\u8ba4\u4e3a\u53ef\u4ee5\u901a\u8fc7\u4f18\u5316sgRNA\u6765\u907f\u514d\u6216\u51cf\u5c11\u201c\u8131\u9776\u201d\uff0c\u4f46\u662f\u5f88\u591a\u4eba\u8ba4\u4e3a\u8981\u505a\u5230\u5b8c\u5168\u4e0d\u8131\u9776\u662f\u4e0d\u53ef\u80fd\u3002\u53bb\u5e74\u516d\u6708\u4efd\uff0c\u5728\u300a\u81ea\u7136\u65b9\u6cd5\u5b66\u300b\u6742\u5fd7\u4e0a\u7684\u4e00\u7bc7\u62a5\u9053\u79f0\uff0c\u4e00\u4e2a\u65e8\u5728\u4fee\u6539\u5931\u660e\u5c0f\u9f20\u6a21\u578b\u4e2d\u5355\u6838\u9178\u53d8\u5f02\u7684CRISPR\u5bfc\u81f4\u4e861600\u4e2a\u57fa\u56e0\u53d8\u5f02\u3002\u56e0\u6b64\uff0c\u8d3a\u6559\u6388\u5728\u4ed6\u7684\u535a\u5ba2\u4e2d\u6b63\u786e\u5730\u6307\u51fa\uff0c\u53ea\u6709\u8fbe\u5230\u201c\u5f88\u5c11\u6216\u6ca1\u6709\u8131\u9776\u7684\u4eba\u7c7b\u80da\u80ce\u624d\u80fd\u6210\u4e3a\u53ef\u80fd\u201d\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u6b64\u5916\uff0c\u4ed6\u8fd8\u63d0\u5230\u76ee\u524d\u57fa\u56e0\u7f16\u8f91\u4e2d\u7684\u5176\u4ed6\u5b89\u5168\u6027\u95ee\u9898\uff0c\u5982\u53d1\u751f\u57fa\u56e0\u201c\u5d4c\u5408\u4f53\u201d(Chimera)\u7684\u95ee\u9898\uff0cCas9\u6838\u9178\u9176\u548csgRNA\u5982\u4f55\u5f71\u54cd\u80da\u80ce\u53d1\u80b2\u7684\u95ee\u9898\uff0c\u4ee5\u53ca\u8fdb\u4e00\u6b65\u8003\u8651\u57fa\u56e0\u7f16\u8f91\u540e\u7684\u591a\u4ee3\u9057\u4f20\u7684\u95ee\u9898\u3002\u57fa\u4e8e\u8fd9\u6837\u7684\u8003\u91cf\uff0c\u8d3a\u6559\u6388\u8ba4\u4e3a\u201c\u76ee\u524d\u7528\u4e8e\u4eba\u7c7b\u751f\u6b96\u76ee\u7684\u57fa\u56e0\u7f16\u8f91\u5c1a\u672a\u89e3\u51b3\u79d1\u5b66\u4e0a\u7684\u5b89\u5168\u6027\u95ee\u9898\uff0c\u5c24\u5176\u662f\u8131\u9776\u548c\u5d4c\u5408\u4f53\u3002\u5728\u89e3\u51b3\u597d\u4ee5\u4e0b\u7684\u5b89\u5168\u6027\u95ee\u9898\u4e4b\u524d\uff0c\u8fdb\u884c\u4eba\u7c7b\u751f\u6b96\u76ee\u7684\u7684\u57fa\u56e0\u7f16\u8f91\u662f\u4e0d\u8d1f\u8d23\u4efb\u7684\u201d\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u96be\u9053\u8fd9\u6837\u7684\u96be\u9898\u5728\u77ed\u77ed\u4e00\u5e74\u91cc\u5c31\u5df2\u7ecf\u88ab\u653b\u514b\u4e86\u5417\uff1f\u800c\u4e14\u4ece\u65f6\u95f4\u4e0a\u770b\uff0c\u5c31\u5728\u8d3a\u6559\u6388\u5199\u4e0b\u8fd9\u6bb5\u8bdd\u7684\u540c\u65f6\uff0c\u8fd9\u4e2a\u8fdd\u80cc\u4ed6\u81ea\u5df1\u7ed3\u8bba\u7684\u4e34\u5e8a\u5df2\u7ecf\u5728\u51c6\u5907\u4e2d\uff0c\u6216\u8005\u5df2\u7ecf\u5f00\u59cb\u4e86\u3002<\/p>\n<p>\u3000\u3000\u3000\u3000<\/p>\n<section class=\"_135editor\"    style=\"font-size: 16px;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;padding-right: 3px;padding-left: 3px;box-sizing: border-box;\">\n<section style=\"width: 6px;height: 6px;margin-left: -3px;border-radius: 100%;color: rgb(255, 255, 255);background-color: rgb(239, 112, 96);box-sizing: border-box;\"><\/section>\n<section style=\"border-left: 1px solid #ef7060;box-sizing: border-box;\">\n<section style=\"padding: 3px 10px;box-sizing: border-box;\">\n<section class=\"135brush\"  style=\"box-sizing: border-box;\"><span style=\"color: #ef7060;font-size: 18px;\"><strong>\u8d28\u75912\uff1a<\/strong><\/span><\/section>\n<\/section>\n<\/section>\n<section style=\"border-top: 1px solid rgb(239, 112, 96);width: 100%;float: left;box-sizing: border-box;\" ><\/section>\n<section style=\"width: 6px;height: 6px;margin-top: -4px;border-radius: 100%;float: right;color: rgb(255, 255, 255);background-color: rgb(239, 112, 96);box-sizing: border-box;\"><\/section>\n<section style=\"border-left: 1px solid rgb(239, 112, 96);box-sizing: border-box;\" class=\"135brush\">\n<section style=\"padding: 3px 10px;box-sizing: border-box;\">\n<p style=\"white-space: normal;\"><span style=\"color: #4f81bd;font-size: 18px;\">\u4eba\u7c7b\u80da\u80ce\u7814\u7a76\u7684\u201c14 \u5929\u6cd5\u5219\u201d<\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"width: 6px;height: 6px;margin-left: -3px;border-radius: 100%;color: rgb(255, 255, 255);background-color: rgb(239, 112, 96);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<p>\u3000\u3000\u3000<\/p>\n<p>\u3000\u3000\u4e16\u754c\u5404\u56fd\u5bf9\u4e8e\u5728\u4eba\u7c7b\u80da\u80ce\u4e2d\u8fdb\u884c\u57fa\u56e0\u7f16\u8f91\u90fd\u6709\u7740\u4e25\u683c\u7684\u7ba1\u63a7\u3002\u8fd9\u4e9b\u7ba1\u63a7\u7684\u76ee\u7684\u5e76\u975e\u201c\u6280\u672f\u6027\u201d\u7684\uff0c\u53ef\u4ee5\u8bf4\u662f\u5b8c\u5168\u51fa\u81ea\u201c\u4f26\u7406\u201d\u65b9\u9762\u7684\u8003\u91cf\u3002\u8fd9\u5c31\u662f\u8bf4\u4ece\u4ec0\u4e48\u65f6\u5019\u5f00\u59cb\uff0c\u80da\u80ce\u53ef\u4ee5\u88ab\u8ba4\u4e3a\u662f\u6709\u4e86\u201c\u751f\u547d\u201d\u3002\u4e5f\u8bb8\u4ece\u5b97\u6559\u4eba\u58eb\u7684\u89c2\u70b9\u6765\u770b\uff0c\u751f\u547d\u4ece\u53d7\u7cbe\u5375\u5f00\u59cb\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u4f46\u662f\uff0c\u4ece\u79d1\u5b66\u7814\u7a76\u7684\u89d2\u5ea6\u4ee5\u53ca\u8003\u8651\u5230\u65e9\u671f\u80da\u80ce\u7684\u5404\u79cd\u4e0d\u786e\u5207\u6027\uff0c\u8fd9\u4e2a\u65f6\u95f4\u6bb5\u53ef\u4ee5\u9002\u5f53\u5730\u653e\u5bbd\u4e00\u4e9b\u3002\u4e2d\u56fd\u79d1\u6280\u90e82003\u5e74\u7684\u6587\u4ef6\u89c4\u5b9a\u4e86\u5173\u4e8e\u4eba\u7c7b\u80da\u80ce\u7814\u7a76\u7684\u201c14 \u5929\u6cd5\u5219\u201d\uff1a\u5373\u5229\u7528\u4f53\u5916\u53d7\u7cbe\u3001\u4f53\u7ec6\u80de\u6838\u79fb\u690d\u3001\u5355\u6027\u590d\u5236\u6280\u672f\u6216\u9057\u4f20\u4fee\u9970\u83b7\u5f97\u7684\u56ca\u80da\uff0c\u5176\u4f53\u5916\u57f9\u517b\u671f\u9650\u81ea\u53d7\u7cbe\u6216\u6838\u79fb\u690d\u5f00\u59cb\u4e0d\u5f97\u8d85\u8fc714\u5929\u3002\u540c\u65f6\uff0c\u4e5f\u4e0d\u5f97\u5c06\u524d\u6b3e\u4e2d\u83b7\u5f97\u7684\u5df2\u7528\u4e8e\u7814\u7a76\u7684\u4eba\u56ca\u80da\u690d\u5165\u4eba\u6216\u4efb\u4f55\u5176\u4ed6\u52a8\u7269\u7684\u751f\u6b96\u7cfb\u7edf\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u5bf9\u6b64\uff0c\u8d3a\u6559\u6388\u4e5f\u662f\u5b8c\u5168\u6e05\u695a\u7684\u3002\u4ed6\u57282017\u5e74\u7684\u535a\u5ba2\u91cc\u5f3a\u8c03\u4f53\u5916\u57f9\u517b\u7684\u4eba\u7c7b\u65e9\u671f\u80da\u80ce\u5fc5\u987b\u201c\u9075\u5b88\u73b0\u6709\u768414\u5929\u89c4\u5219\u201d\u3002 \u8d3a\u6559\u6388\u73b0\u5728\u9700\u8981\u62ff\u51fa\u5145\u5206\u7406\u7531\u6765\u8bf4\u660e\uff0c\u4e3a\u4ec0\u4e48\u4ed6\u7684\u8fd9\u6b21\u4e34\u5e8a\u8bd5\u9a8c\u53ef\u4ee5\u8d85\u8d8a\u56fd\u5bb6\u5141\u8bb8\u768414\u5929\u89c4\u5219\uff1f\u540c\u65f6\u7528\u5145\u5206\u7684\u79d1\u5b66\u6570\u636e\u6765\u8bf4\u660e\u8fd9\u4e00\u6b21\u80da\u80ce\u57fa\u56e0\u7f16\u8f91\u7684\u5b89\u5168\u6027\u3002\u8fd9\u5e76\u975e\u662f\u7ed9\u56fd\u5bb6\u76d1\u7ba1\u90e8\u95e8\u548c\u79d1\u5b66\u754c\u7684\u4e00\u4e2a\u56de\u5e94\uff0c\u66f4\u91cd\u8981\u7684\u662f\u5bf9\u8fd9\u4e24\u4e2a\u5df2\u7ecf\u51fa\u751f\u7684\u65b0\u751f\u547d\u7684\u8d23\u4efb\u3002<\/p>\n<p>\u3000\u3000\u3000\u3000<\/p>\n<section class=\"_135editor\"    style=\"font-size: 16px;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;padding-right: 3px;padding-left: 3px;box-sizing: border-box;\">\n<section style=\"width: 6px;height: 6px;margin-left: -3px;border-radius: 100%;color: rgb(255, 255, 255);background-color: rgb(239, 112, 96);box-sizing: border-box;\"><\/section>\n<section style=\"border-left: 1px solid #ef7060;box-sizing: border-box;\">\n<section style=\"padding: 3px 10px;box-sizing: border-box;\">\n<section class=\"135brush\"  style=\"box-sizing: border-box;\"><span style=\"color: #ef7060;font-size: 18px;\"><strong>\u8d28\u75913\uff1a<\/strong><\/span><\/section>\n<\/section>\n<\/section>\n<section style=\"border-top: 1px solid rgb(239, 112, 96);width: 100%;float: left;box-sizing: border-box;\" ><\/section>\n<section style=\"width: 6px;height: 6px;margin-top: -4px;border-radius: 100%;float: right;color: rgb(255, 255, 255);background-color: rgb(239, 112, 96);box-sizing: border-box;\"><\/section>\n<section style=\"border-left: 1px solid rgb(239, 112, 96);box-sizing: border-box;\" class=\"135brush\">\n<section style=\"padding: 3px 10px;box-sizing: border-box;\">\n<p style=\"white-space: normal;\"><span style=\"color: #4f81bd;font-size: 18px;\">\u5173\u4e8e\u8fd9\u4e00\u9879\u76ee\u7684\u5b89\u5168\u6027\u4fdd\u969c\uff0c\u5982\u4f55\u8bf4\u670d\u4f26\u7406\u59d4\u5458\u4f1a\uff1f<\/span><\/p>\n<\/section>\n<\/section>\n<section style=\"width: 6px;height: 6px;margin-left: -3px;border-radius: 100%;color: rgb(255, 255, 255);background-color: rgb(239, 112, 96);box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<p>\u3000\u3000\u3000\u3000<\/p>\n<p>\u3000\u3000\u8d3a\u6559\u6388\u8fd9\u6b21\u51e0\u4e4e\u83b7\u5f97\u5168\u4e16\u754c\u79d1\u5b66\u5bb6\u8c34\u8d23\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4e5f\u5f15\u8d77\u4e86\u5927\u5bb6\u5bf9\u4e2d\u56fd\u533b\u7597\u673a\u6784\u201c\u4f26\u7406\u59d4\u5458\u4f1a\u201d\uff08Ethics Committee\uff09\u7ba1\u7406\u65b9\u6cd5\u4e25\u91cd\u7684\u8d28\u7591\u3002\u4f26\u7406\u59d4\u5458\u4f1a\u5efa\u7acb\u7684\u76ee\u7684\u662f\u8981\u9632\u6b62\u4e34\u5e8a\u533b\u751f\u5728\u75c5\u4eba\u4f53\u5185\u8fdb\u884c\u4efb\u4f55\u8fdd\u53cd\u57fa\u672c\u4f26\u7406\u7684\u8bd5\u9a8c\u3002\u6b63\u56e0\u4e3a\u5982\u6b64\uff0c\u4f26\u7406\u59d4\u5458\u4f1a\u7684\u6210\u5458\u5e76\u4e0d\u4ec5\u4ec5\u5c40\u9650\u4e8e\u4e13\u4e1a\u4eba\u58eb\u3002\u6309\u7167\u89c4\u5b9a\uff0c\u201c\u673a\u6784\u4f26\u7406\u59d4\u5458\u4f1a\u7684\u59d4\u5458\u7531\u8bbe\u7acb\u8be5\u4f26\u7406\u59d4\u5458\u4f1a\u7684\u90e8\u95e8\u6216\u8005\u673a\u6784\u5728\u5e7f\u6cdb\u5f81\u6c42\u610f\u89c1\u7684\u57fa\u7840\u4e0a\uff0c\u4ece\u751f\u7269\u533b\u5b66\u9886\u57df\u548c\u7ba1\u7406\u5b66\u3001\u4f26\u7406\u5b66\u3001\u6cd5\u5b66\u3001\u793e\u4f1a\u5b66\u7b49\u793e\u4f1a\u5b66\u79d1\u9886\u57df\u7684\u4e13\u5bb6\u4e2d\u63a8\u8350\u4ea7\u751f\u201d\uff08https:\/\/baike.baidu.com\/item\/\u4f26\u7406\u59d4\u5458\u4f1a\/8884401?fr=aladdin\uff09\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u867d\u7136\u6211\u4eec\u6ca1\u6709\u770b\u5230\u5f53\u65f6\u4f26\u7406\u59d4\u5458\u4f1a\u8ba8\u8bba\u7684\u8bb0\u5f55\uff0c\u4f46\u662f\u4ec5\u4ec5\u53c2\u8003\u4e00\u4e0b\u8d3a\u6559\u6388\u81ea\u5df1\u7684\u8fd9\u4efd\u535a\u5ba2\uff0c\u5c31\u5f88\u96be\u60f3\u8c61\u4ed6\u5f53\u65f6\u662f\u5982\u4f55\u5411\u8fd9\u6837\u4e00\u4e2a\u5305\u542b\u591a\u65b9\u9762\u4eba\u58eb\u7684\u4f26\u7406\u59d4\u5458\u4f1a\u8bf4\u660e\u8fd9\u4e00\u9879\u76ee\u7684\u5b89\u5168\u6027\u4fdd\u969c\uff0c\u800c\u66f4\u96be\u60f3\u8c61\u4f26\u7406\u59d4\u5458\u4f1a\u6210\u5458\u5728\u8d3a\u6559\u6388\u505a\u51fa\u7684\u4e0a\u8ff0\u201c\u5728\u89e3\u51b3\u597d\u5b89\u5168\u6027\u95ee\u9898\u4e4b\u524d\uff0c\u8fdb\u884c\u4eba\u7c7b\u751f\u6b96\u76ee\u7684\u7684\u57fa\u56e0\u7f16\u8f91\u662f\u4e0d\u8d1f\u8d23\u4efb\u7684\u201d\u7ed3\u8bba\u60c5\u51b5\u4e0b\uff0c\u53c8\u662f\u5982\u4f55\u6279\u51c6\u8fd9\u4e2a\u4e16\u754c\u4e0a\u9996\u6b21\u7684\u4eba\u7c7b\u80da\u80ce\u57fa\u56e0\u7f16\u8f91\u4e34\u5e8a\u8bd5\u9a8c\u7684\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u8d3a\u5efa\u9035\u662f\u5357\u79d1\u5927\u7684\u526f\u6559\u6388\uff0c\u4f46\u4ed6\u5374\u9009\u62e9\u5728\u4e00\u5bb6\u6c11\u8425\u533b\u9662\u4e2d\u901a\u8fc7\u4f26\u7406\u6279\u51c6\u5e76\u5f00\u5c55\u4e34\u5e8a\u3002\u4e8b\u5b9e\u4e0a\uff0c\u5f88\u591a\u8fd9\u79cd\u5730\u65b9\u7684\u201c\u4f26\u7406\u59d4\u5458\u4f1a\u201d\u5df2\u6210\u4e3a\u5f00\u5c55\u5404\u79cd\u975e\u6b63\u89c4\u4e34\u5e8a\u7684\u4e00\u5f20\u8584\u8584\u7684\u7eb1\u95e8\u3002\u5982\u679c\u6211\u4eec\u56de\u987e\u4e00\u4e0b\u8fd9\u51e0\u5e74\u6765\u53d1\u751f\u7684\u4e0e\u4e34\u5e8a\u8bd5\u9a8c\u6709\u5173\u7684\u4e8b\u4ef6\uff0c\u4ece\u201c\u9b4f\u5219\u897f\u201d\u5230\u6700\u8fd1\u7684CAR-T\u6cbb\u7597\u7b49\uff0c\u65e0\u4e0d\u548c\u76ee\u524d\u8fd9\u79cd\u8fd1\u4e4e\u653e\u4efb\u81ea\u6d41\u7684\u673a\u6784\u672c\u8eab\u201c\u4f26\u7406\u59d4\u5458\u4f1a\u201d\u6279\u51c6\u65b9\u6cd5\u6709\u5173\u3002\u4e16\u754c\u5404\u56fd\u5bf9\u533b\u836f\u4e34\u5e8a\u4e25\u683c\u7684\u76d1\u7ba1\u662f\u7528\u751f\u547d\u6362\u6765\u7684\u7ed3\u679c\u3002\u96be\u9053\u6211\u4eec\u4e5f\u8fd8\u9700\u8981\u7ee7\u7eed\u7528\u751f\u547d\u6765\u201c\u4ea4\u5b66\u8d39\u201d\u5417\uff1f<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u81f3\u4e8e\u628aCCR5 \u800c\u4e0d\u662f\u5176\u4ed6\u751f\u547d\u6538\u5173\u7684\u57fa\u56e0\u53d8\u5f02\u4f5c\u4e3a\u8fd9\u6b21\u57fa\u56e0\u7f16\u8f91\u7684\u5bf9\u8c61\uff0c\u5df2\u7ecf\u6709\u5f88\u591aHIV\u4e13\u5bb6\u6307\u51fa\u5176\u4e2d\u7684\u8c2c\u8bef\u3002\u800c\u66fe\u7ecf\u4e0e\u8d3a\u6559\u6388\u540c\u65f6\u53c2\u52a02017\u5e74\u56fd\u9645\u8bba\u575b\u7684\u8457\u540d\u7684\u7f8e\u56fd\u57fa\u56e0\u7f16\u8f91\u4e13\u5bb6 George Church \u6559\u6388\u4e5f\u8bb8\u770b\u5f97\u66f4\u900f\u3002\u4ed6\u8bf4\uff0c\u201d\u91c7\u7528\u4eba\u7c7b\u80da\u80ce\u505a\u8bd5\u9a8c\u8bf4\u660e\u7814\u7a76\u4eba\u5458\u7684\u76ee\u7684\u662f\u5728\u8bd5\u9a8c\u8fd9\u4e2a\u65b9\u6cd5\uff0c\u800c\u4e0d\u662f\u907f\u514d\uff08\u5b69\u5b50\u5c06\u6765\uff09\u5f97\u75c5\u3002\u201d\uff08The use of that embryo suggests that the researchers\u2019 main emphasis was on testing editing rather than avoiding this disease\uff09<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u770b\u6765\uff0c\u8d3a\u6559\u6388\u9700\u8981\u9762\u5bf9\u5f88\u591a\u4eba\u7684\u8d28\u7591\uff0c\u800c\u4ed6\u672a\u6765\u6700\u5927\u7684\u8d28\u7591\u8005\u5c06\u4f1a\u6765\u81ea\u8fd9\u4e24\u4e2a\u521a\u521a\u51fa\u751f\u7684\u5b69\u5b50\u3002<\/p>\n<p><br  \/><\/p>\n<p><strong style=\"font-size: 16px;white-space: normal;color: rgb(62, 62, 62);max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(79, 129, 189);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u25a0\u7f16\u8f91&nbsp;\u4f59\u5982\u747e<\/span><\/strong><\/p>\n<p><strong style=\"font-size: 16px;white-space: normal;color: rgb(62, 62, 62);max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(79, 129, 189);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/span><\/strong><\/p>\n<section  class=\"_135editor\" style=\"font-size: 16px;border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;font-family: \u5fae\u8f6f\u96c5\u9ed1;transform: none;\"  >\n<section style=\"width: 100%;box-sizing: border-box;color: inherit;\" >\n<section style=\"border-width: 0px;border-style: initial;border-color: initial;box-sizing: border-box;clear: both;overflow: hidden;color: inherit;\">\n<section style=\"box-sizing: border-box;display: inline-block;color: inherit;\">\n<section style=\"color: inherit;box-sizing: border-box;\">\n<p style=\"display: inline-block;padding-right: 10px;color: inherit;white-space: normal;background-color: #fefefe;\"><span style=\"color: #4f81bd;font-size: 20px;\"><strong>\u6700\u65b0\u8fdb\u5c55&gt;&gt;&gt;<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"height: 2px;margin-top: -14px;color: rgb(255, 255, 255);border-color: rgb(241, 201, 196);box-sizing: border-box;background-color: rgb(239, 112, 96);\"><\/section>\n<\/section>\n<\/section>\n<p><br  \/><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;\"><strong><span style=\"font-size: 14px;color: rgb(84, 141, 212);\">\u6df1\u5733\u5e02\u533b\u5b66\u4f26\u7406\u4e13\u5bb6\u59d4\u5458\u4f1a\u7684\u56de\u5e94<\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/6-1544158693.jpg\" alt=\"\u4e09\u95ee\u4eba\u7c7b\u80da\u80ce\u57fa\u56e0\u7f16\u8f91\u201c\u4f26\u7406\u95e8\u201d\" title=\"\u4e09\u95ee\u4eba\u7c7b\u80da\u80ce\u57fa\u56e0\u7f16\u8f91\u201c\u4f26\u7406\u95e8\u201d\"  \/><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;\"><strong><span style=\"font-size: 14px;color: rgb(84, 141, 212);\">\u4e00\u4e9b\u4e2d\u56fd\u79d1\u5b66\u5bb6\u7684\u8054\u7f72\u58f0\u660e<\/span><\/strong><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/8-1544158694.jpeg\" alt=\"\u4e09\u95ee\u4eba\u7c7b\u80da\u80ce\u57fa\u56e0\u7f16\u8f91\u201c\u4f26\u7406\u95e8\u201d\" title=\"\u4e09\u95ee\u4eba\u7c7b\u80da\u80ce\u57fa\u56e0\u7f16\u8f91\u201c\u4f26\u7406\u95e8\u201d\"  \/><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/2-1544158695.jpeg\" alt=\"\u4e09\u95ee\u4eba\u7c7b\u80da\u80ce\u57fa\u56e0\u7f16\u8f91\u201c\u4f26\u7406\u95e8\u201d\" title=\"\u4e09\u95ee\u4eba\u7c7b\u80da\u80ce\u57fa\u56e0\u7f16\u8f91\u201c\u4f26\u7406\u95e8\u201d\"  \/><\/p>\n<p><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/6-1544158697.jpeg\" alt=\"\u4e09\u95ee\u4eba\u7c7b\u80da\u80ce\u57fa\u56e0\u7f16\u8f91\u201c\u4f26\u7406\u95e8\u201d\" title=\"\u4e09\u95ee\u4eba\u7c7b\u80da\u80ce\u57fa\u56e0\u7f16\u8f91\u201c\u4f26\u7406\u95e8\u201d\"  \/><\/p>\n<p style=\"text-align: left;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\uff08\u6765\u6e90\uff1a\u77e5\u8bc6\u5206\u5b50\uff09<\/span><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;\"><br  \/><\/p>\n<p style=\"white-space: normal;text-align: center;\"><img class=\"\"       src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/8-1544158698.jpeg\" alt=\"\u4e09\u95ee\u4eba\u7c7b\u80da\u80ce\u57fa\u56e0\u7f16\u8f91\u201c\u4f26\u7406\u95e8\u201d\" title=\"\u4e09\u95ee\u4eba\u7c7b\u80da\u80ce\u57fa\u56e0\u7f16\u8f91\u201c\u4f26\u7406\u95e8\u201d\"  \/><\/p>\n<p style=\"white-space: normal;text-align: center;\"><strong style=\"color: rgb(62, 62, 62);font-size: 16px;max-width: 100%;line-height: 25.6px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(79, 129, 189);font-family: \u5b8b\u4f53;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/span><\/strong><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u3000\u3000\u6628\u5929\uff0c\u6765\u81ea\u4e2d\u56fd\u6df1\u5733\u7684\u8d3a\u5efa\u594e\u526f\u6559\u6388\u5728\u7b2c\u4e8c\u5c4a\u56fd\u9645\u4eba\u7c7b\u57fa\u56e0\u7ec4\u7f16\u8f91\u5cf0\u4f1a\u53ec\u5f00\u524d\u4e00\u5929\u5ba3\u5e03\uff0c\u4e00\u5bf9\u540d\u4e3a\u201c\u9732\u9732\u201d\u548c\u201c\u5a1c\u5a1c\u201d\u7684 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":71711,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/71710"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=71710"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/71710\/revisions"}],"predecessor-version":[{"id":71718,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/71710\/revisions\/71718"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/71711"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=71710"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=71710"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=71710"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}