{"id":71987,"date":"2018-11-16T01:00:00","date_gmt":"2018-12-07T05:01:15","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/494283c9db\/"},"modified":"2018-12-07T13:01:17","modified_gmt":"2018-12-07T05:01:17","slug":"494283c9db","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/71987\/","title":{"rendered":"NSCLC\u8f6c\u5316\u7814\u7a76\u65b9\u5174\u672a\u827e \u9776\u5411\u80bf\u7624\u8fdb\u5316\u6216\u6210\u65b0\u98ce\u6f6e"},"content":{"rendered":"
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\"NSCLC\u8f6c\u5316\u7814\u7a76\u65b9\u5174\u672a\u827e<\/p>\n


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\"NSCLC\u8f6c\u5316\u7814\u7a76\u65b9\u5174\u672a\u827e<\/p>\n
\u7acb\u523b\u626b\u7801\uff01<\/strong><\/section>\n<\/section>\n
\n

\u7275\u624b\u533b\u5c4a\u5927\u5496<\/span><\/strong><\/span><\/p>\n

\u805a\u7126\u5b66\u672f\u524d\u6cbf<\/span><\/strong><\/p>\n

\u8bf7\u5173\u6ce8
<\/strong><\/span><\/p>\n

\u5b50\u53f7\u201c\u514d\u75ab\u65f6\u95f4<\/span>\u201d<\/strong><\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\"NSCLC\u8f6c\u5316\u7814\u7a76\u65b9\u5174\u672a\u827e<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\n

\u6765\u6e90\uff1a\u514d\u75ab\u65f6\u95f4<\/span><\/p>\n<\/blockquote>\n


<\/p>\n

\u3000\u3000\u8fd1\u5e74\u6765\uff0c\u80bf\u7624\u836f\u7269\u7814\u53d1\u5728\u56fd\u5185\u53ef\u4ee5\u8bf4\u662f\u975e\u5e38\u706b\u70ed\uff0c\u5c24\u5176\u5728\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u836f\u7269\u65b9\u9762\u5df2\u7ecf\u51fa\u73b0\u4e25\u91cd\u7684\u201c\u624e\u5806\u201d\u73b0\u8c61\uff0c\u4f46\u8fd9\u4e5f\u63a8\u52a8\u4e86\u76f8\u5173\u9886\u57df\u4e34\u5e8a\u7814\u7a76\uff0c\u5e26\u6765\u4e86\u66f4\u591a\u60a3\u8005\u6cbb\u7597\u6570\u636e\u3002<\/p>\n


<\/p>\n

      \u5176\u4e2d\uff0c\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u8f6c\u5316\u7814\u7a76\u5f97\u5230\u4f17\u591a\u4e34\u5e8a\u4e13\u5bb6\u5173\u6ce8\u3002<\/strong><\/span>\u4e2d\u534e\u533b\u5b66\u4f1a\u5168\u56fd\u547c\u5438\u5206\u4f1a\u80ba\u764c\u5b66\u7ec4\u59d4\u5458\u3001\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u745e\u91d1\u533b\u9662\u547c\u5438\u79d1\u4e3b\u4efb\u9ad8\u84d3\u8389\u5728\u8fd1\u671f\u4e3e\u529e\u7684\u4e9a\u6d32\u80ba\u764c\u5927\u4f1a\u5206\u4eab\u4e86\u5979\u7684\u5fc3\u5f97\u3002
<\/p>\n


<\/p>\n

\n

\u4e2d\u534e\u533b\u5b66\u4f1a\u5168\u56fd\u547c\u5438\u5206\u4f1a\u80ba\u764c\u5b66\u7ec4\u59d4\u5458\u3001\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u745e\u91d1\u533b\u9662\u547c\u5438\u79d1\u4e3b\u4efb\u9ad8\u84d3\u8389<\/strong><\/span><\/p>\n


<\/p>\n

\n
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\u7f29\u77ed\u65b0\u53d1\u65f6\u95f4<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u3000\u3000\u201c\u5176\u5b9e\uff0c\u8f6c\u5316\u533b\u5b66\u63d0\u51fa\u7684\u80cc\u666f\u5c31\u662f\u57fa\u7840\u7814\u7a76\u4e0e\u4e34\u5e8a\u5e94\u7528\u8131\u8282\uff0c\u79d1\u7814\u6295\u5165\u4e0e\u4ea7\u51fa\u4e25\u91cd\u5931\u8861\u3002\u201d\u9ad8\u84d3\u8389\u4e00\u9488\u89c1\u8840\u5730\u6307\u51fa\uff0c\u5c3d\u7ba1\u75be\u75c5\u673a\u5236\u7684\u7814\u7a76\u8d8a\u6765\u8d8a\u6df1\u5165\uff0c\u4f46\u5e76\u6ca1\u6709\u5e26\u6765\u65b0\u7684\u8bca\u65ad\u3001\u6cbb\u7597\u3001\u9884\u9632\u7684\u65b9\u6cd5\uff0c\u4ee5\u81f4\u6295\u5165\u8fdc\u8fdc\u5927\u4e8e\u4ea7\u51fa\u3002\u4e3a\u6b64\uff0c\u5b66\u754c\u63d0\u51fa\u8f6c\u5316\u533b\u5b66\u7684\u6982\u5ff5\uff0c\u6784\u5efa\u4e34\u5e8a\u5b9e\u8df5\u4e0e\u57fa\u7840\u7814\u7a76\u4e4b\u95f4\u7684\u5faa\u73af\u5f0f\u7684\u7814\u7a76\u4f53\u7cfb\u3002<\/p>\n


<\/p>\n

\u3000\u3000\u5c31\u80bf\u7624\u9886\u57df\u800c\u8a00\uff0c\u8fd110\u5e74\u5df2\u6709\u591a\u8d77\u4e0e\u8f6c\u5316\u533b\u5b66\u76f8\u5173\u7684\u4e8b\u4ef6\uff0c\u5176\u4e2d\u5178\u578b\u7684\u5982\u80ba\u764cEGFR\u7a81\u53d8\u4e0e\u5384\u6d1b\u66ff\u5c3c\u7597\u6548\u7684\u7814\u7a76\uff0c\u5982\u5927\u89c4\u6a21\u7ec6\u80de\u7cfb\u7b5b\u67e5\u53d1\u73b0\u4e86\u6cbb\u7597NSCLC\u7684ALK\u6291\u5236\u5242\uff0c\u514d\u75ab\u6cbb\u7597\u7684\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff0c\u57fa\u56e0\u5de5\u7a0b\u6539\u9020\u7684T\u7ec6\u80de\uff0c\u8fd8\u6709\u4ece\u5faa\u73af\u80bf\u7624\u7ec6\u80de\u4e2d\u7814\u53d1\u4e2a\u4f53\u5316\u9a71\u52a8\u7684\u80bf\u7624\u6a21\u578b\u7528\u4e8e\u524d\u77bb\u6027\u836f\u7269\u6d4b\u8bd5\u7b49\u7b49\u3002<\/p>\n


<\/p>\n

\u3000\u3000\u800c\u80ba\u764c\u7cbe\u51c6\u533b\u5b66\u8f6c\u5316\u7814\u7a76\u7684\u5178\u8303\uff0c\u83ab\u8fc7\u4e8e\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08EGFR-TKI\uff09\u7597\u6548\u9884\u6d4b\u6807\u5fd7\u7269\u7684\u786e\u8ba4\u30022002\u5e74IRESSA\u5728\u65e5\u672c\u9996\u6b21\u83b7\u6279\u540e\uff0c\u5b66\u754c\u56f4\u7ed5\u5409\u975e\u66ff\u5c3c\u7597\u6548\u9884\u6d4b\u7684\u7684\u6307\u6807\u5230\u5e95\u662fEGFR\u86cb\u767d\u8868\u8fbe\u3001EGFR\u57fa\u56e0\u62f7\u8d1d\u6570\u8fd8\u662fEGFR\u7a81\u53d8\u4e89\u8bae\u4e0d\u65ad\uff0c\u4e34\u5e8a\u533b\u751f\u4e5f\u7f3a\u4e4f\u7279\u5b9a\u6807\u51c6\u6765\u7b5b\u9009\u5409\u975e\u66ff\u5c3c\u6cbb\u7597\u7684\u4f18\u52bf\u4eba\u7fa4\u3002\u76f4\u52302009\u5e74\u53d1\u8868\u7684\u4e00\u7bc7\u968f\u673a\u5bf9\u7167\u7814\u7a76\uff08IPASS\u7814\u7a76\uff09\uff0c\u786e\u8ba4\u4e86EGFR\u7a81\u53d8\u4e3aEGFR-TKI\u7597\u6548\u9884\u6d4b\u56e0\u5b50\uff0c\u7531\u6b64\u5f00\u542f\u4e86\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u9776\u5411\u6cbb\u7597\u65f6\u4ee3\u3002<\/strong><\/span><\/p>\n


<\/p>\n

\u3000\u3000ALK\u9a71\u52a8\u57fa\u56e0\u53caALK-TKI\u5219\u662f\u53e6\u4e00\u4e2a\u5178\u8303\u3002\u201c\u53ef\u4ee5\u8bf4ALK\u901a\u8def\u4ece\u8bca\u65ad\u3001\u4e34\u5e8a\u7814\u7a76\u5230\u6700\u540e\u83b7\u6279\uff0c\u8f6c\u5316\u533b\u5b66\u53d1\u6325\u7740\u975e\u5e38\u5173\u952e\u7684\u4f5c\u7528\u3002\u201d\u9ad8\u84d3\u8389\u68b3\u7406\u9053\uff0c1994\u5e74\u5728\u95f4\u53d8\u6027\u5927\u7ec6\u80de\u6dcb\u5df4\u7624\u4e2d\u53d1\u73b0NPM-ALK\u878d\u5408\uff0c2005\u5e74\u53d1\u73b0\u514b\u5511\u66ff\u5c3c\uff0c2007\u5e74\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e2d\u53d1\u73b0EML4-ALK\u878d\u5408\uff0c\u968f\u540e\u5728\u514b\u5511\u66ff\u5c3c\u2161\u671f\u4e34\u5e8aPROFILE 1001\u548c PROFILE 1005\u5370\u8bc1\u4e86\u5bf9ALK\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u4f5c\u7528\uff0c\u6700\u540e\u57282011\u5e74\u514b\u5511\u66ff\u5c3c\u83b7\u5f97\u7f8e\u56fdFDA\u6279\u51c6\u3002<\/p>\n


<\/p>\n

\u3000\u3000\u5728\u9ad8\u84d3\u8389\u770b\u6765\uff0c\u76ee\u524d\u9776\u5411\u836f\u7269\u8010\u836f\u673a\u5236\u7684\u63a2\u7d22\u4e5f\u6b63\u8df5\u884c\u7740\u8f6c\u5316\u533b\u5b66\u7684\u505a\u6cd5\u3002\u901a\u8fc7\u4e34\u5e8a\u660e\u786e\u9776\u5411\u8010\u836f\u673a\u5236\uff0c\u4ece\u800c\u50ac\u751f\u514b\u670d\u8010\u836f\u7684\u65b0\u4e00\u4ee3\u9776\u5411\u65b0\u53d1\u3002\u4e0d\u4ec5\u5982\u6b64\uff0c\u5bf9EGFR\u3001KRAS\u3001ALK\u7b49\u591a\u79cd\u7a81\u53d8\u5206\u5b50\u7684\u7814\u7a76\uff0c\u4e5f\u8ba9\u5b66\u754c\u91cd\u65b0\u5b9a\u4e49\u4e86\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u5206\u578b\u3002<\/p>\n


<\/p>\n

\u3000\u3000\u201c\u4ee5\u9a71\u52a8\u57fa\u56e0\u4e3a\u57fa\u7840\u5927\u5927\u7f29\u77ed\u4e86\u80ba\u764c\u65b0\u53d1\u65f6\u95f4\u3002\u201d\u9ad8\u84d3\u8389\u6307\u51fa\uff0c\u5728\u591a\u53d8\u91cf\u6a21\u578b\u4e2d\uff0c\u6839\u636e\u4e2a\u4f53\u5316\u72b6\u6001\u7684\u836f\u7269\u5206\u7c7b\u662f\u552f\u4e00\u4e0e\u4e34\u5e8a\u836f\u7269\u7814\u53d1\u603b\u65f6\u95f4\u66f4\u5feb\u76f8\u5173\u7684\u72ec\u7acb\u56e0\u7d20\u30022016\u5e74\u53d1\u8868\u7684\u4e00\u9879\u7edf\u8ba1\u663e\u793a\uff0c\u9776\u5411\u4e2a\u4f53\u5316\u836f\u7269\u4e0e\u9776\u5411\u975e\u4e2a\u4f53\u5316\u836f\u7269\u3001\u7ec6\u80de\u6bd2\u836f\u7269\u76f8\u6bd4\uff0c\u4ece\u7814\u53d1\u5230\u83b7\u6279\u7684\u65f6\u95f4\u5206\u522b\u662f64.6\u4e2a\u6708\u300187.1\u4e2a\u6708\u53ca112.7\u4e2a\u6708\u3002<\/strong><\/span><\/p>\n


<\/p>\n

\n
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\u80ba\u764c\u8f6c\u5316\u7814\u7a76\u672a\u6765\u673a\u4f1a<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u3000\u3000\u201c\u76ee\u524d\u80ba\u764c\u8f6c\u5316\u7814\u7a76\u70ed\u70b9\u4e3b\u8981\u805a\u7126\u5728\u514d\u75ab\u6cbb\u7597\u3002\u201d\u9ad8\u84d3\u8389\u5206\u6790\u6307\u51fa\uff0c\u5176\u4e2d\u6700\u5927\u7684\u539f\u56e0\u662f\u6240\u6709\u7684\u764c\u75c7\u90fd\u6709\u4ece\u514d\u75ab\u6cbb\u7597\u4e2d\u6f5c\u5728\u83b7\u76ca\u7684\u53ef\u80fd\u3002 \u201c\u514d\u75ab\u5206\u5b50\u6807\u5fd7\u7269\u548c\u514d\u75ab\u8010\u836f\u673a\u5236\uff0c\u662f\u80ba\u764c\u514d\u75ab\u8f6c\u5316\u7814\u7a76\u7684\u70ed\u70b9\u3002\u201d<\/p>\n


<\/p>\n

\u3000\u3000\u4e0e\u9776\u5411\u6cbb\u7597\u4e0d\u540c\uff0c\u514d\u75ab\u6cbb\u7597\u7684\u654f\u611f\u6027\u548c\u8010\u836f\u6027\u7531\u80bf\u7624\u7ec6\u80de\u548c\u80bf\u7624\u5fae\u73af\u5883\u591a\u79cd\u56e0\u7d20\u51b3\u5b9a\u3002\u9ad8\u84d3\u8389\u5efa\u8bae\uff0c\u80ba\u764c\u514d\u75ab\u6cbb\u7597\u65b9\u9762\u7684\u8f6c\u5316\u7814\u7a76\u53ef\u91cd\u70b9\u653e\u5728\u514d\u75ab\u5206\u5b50\u6807\u5fd7\u7269\u3001\u8054\u5408\u6cbb\u7597\u7b56\u7565\u3001\u5168\u7a0b\u5316\u7ba1\u7406\u4ee5\u53ca\u8010\u836f\u6027\u7b49\u95ee\u9898\u3002<\/span><\/strong><\/p>\n


<\/p>\n

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<\/p>\n

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