{"id":72076,"date":"2018-11-11T01:00:00","date_gmt":"2018-12-07T05:02:14","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/8156505c5b\/"},"modified":"2018-12-07T13:02:16","modified_gmt":"2018-12-07T05:02:16","slug":"8156505c5b","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/72076\/","title":{"rendered":"\u76f4\u51fbACLC | \u7b2c\u4e09\u4ee3ALK\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u6216\u963f\u6cd5\u66ff\u5c3c+\u5965\u5e0c\u66ff\u5c3c\u7b49\u4e3a\u80ba\u764c\u60a3\u8005\u83b7\u5f97\u6301\u7eed\u7597\u6548\u84c4\u529b"},"content":{"rendered":"
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\u3000\u3000\u201c\u76ee\u524d\u80ba\u764c\u7684\u60a3\u8005\u751f\u5b58\u671f\u4ece\u8fc7\u53bb\u768410\u4e2a\u6708\u5ef6\u957f\u52303-4\u5e74\uff0c\u672a\u6765\u80ba\u764c\u836f\u7269\u7814\u53d1\u8981\u653b\u514b\u836f\u7269\u7684\u8010\u836f\u6027\u95ee\u9898\uff0c\u514d\u75ab\u6cbb\u7597\u548c\u5206\u5b50\u9776\u5411\u836f\u7269\u7684\u8054\u5408\u6cbb\u7597\uff0c\u8ba9\u80ba\u764c\u7684\u6cbb\u7597\u66f4\u503c\u5f97\u671f\u5f85\uff0c\u7531\u6b64\u4e5f\u4f7f\u2018\u80ba\u764c\u75c5\u4eba\u53d8\u6210\u6162\u6027\u75c5\u75c5\u4eba\u2019\u6210\u4e3a\u53ef\u80fd\u3002\u201d11\u67088-10\u65e5\uff0c\u7531\u56fd\u9645\u80ba\u764c\u7814\u7a76\u5b66\u4f1a\u4e3e\u529e\u7684\u4e9a\u6d32\u80ba\u764c\u5927\u4f1a\uff08IASLC Asia Conference on Lung Cancer,ACLC\uff09\u5728\u5e7f\u5dde\u4e3e\u529e\uff0c\u672c\u6b21\u4e9a\u6d32\u80ba\u764c\u5927\u4f1a\u4e3b\u5e2d\u3001\u4e2d\u56fd\u80f8\u90e8\u80bf\u7624\u7814\u7a76\u534f\u4f5c\u7ec4\u4e3b\u5e2d\u5434\u4e00\u9f99\u5728\u4f1a\u4e0a\u8868\u793a\u3002<\/p>\n


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\u4e2d\u56fd\u80f8\u90e8\u80bf\u7624\u7814\u7a76\u534f\u4f5c\u7ec4\u4e3b\u5e2d\u3001\u5e7f\u4e1c\u7701\u4eba\u6c11\u533b\u9662\u7ec8\u8eab\u4e3b\u4efb\u3001<\/strong><\/span>\u5e7f\u4e1c\u7701\u80ba\u764c\u7814\u7a76\u6240\u540d\u8a89\u6240\u957f\u5434\u4e00\u9f99<\/strong><\/p>\n


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\u3000\u3000\u8fd9\u662f\u56fd\u9645\u80ba\u764c\u7814\u7a76\u534f\u4f1a\u9996\u6b21\u4e3b\u529e\u4e9a\u6d32\u80ba\u764c\u5927\u4f1a\uff0c\u7531\u4e2d\u56fd\u6297\u764c\u534f\u4f1a\u80ba\u764c\u4e13\u4e1a\u59d4\u5458\u4f1a\u3001\u4e2d\u56fd\u80f8\u90e8\u80bf\u7624\u7814\u7a76\u534f\u4f5c\u7ec4\u5171\u540c\u5408\u4f5c\u4e3b\u529e\u3002<\/p>\n


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\u3000\u3000\u80ba\u764c\u662f\u5168\u7403\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u6700\u9ad8\u7684\u6076\u6027\u80bf\u7624\u4e4b\u4e00\uff0c\u6bcf\u5e74\u7ea6\u6709160\u4e07\u4eba\u6b7b\u4e8e\u80ba\u764c\uff1b\u800c\u5728\u4e2d\u56fd\uff0c\u6bcf\u5e74\u80ba\u764c\u65b0\u53d1\u75c5\u4f8b\u8fbe78.1\u4e07\u4f8b\uff0c\u76f8\u5f53\u4e8e\u5e73\u5747\u6bcf10\u5206\u949f\u5c31\u670915\u4eba\u7f79\u60a3\u75be\u75c5\uff0c\u800c\u4e14\u8fd9\u4e00\u6570\u5b57\u8fd8\u5728\u4e0a\u5347\uff0c\u9884\u6d4b\u52302020\u5e74\uff0c\u6bcf\u5e74\u65b0\u53d1\u75c5\u4f8b\u548c\u6b7b\u4ea1\u75c5\u4f8b\u5c06\u5206\u522b\u8d85\u8fc780\u4e07\u548c70\u4e07\u3002<\/p>\n


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\u3000\u3000\u80ba\u764c\u7684\u53d1\u75c5\u7387\u5728\u5168\u7403\u6765\u8bb2\u603b\u4f53\u662f\u5448\u4e0a\u5347\u8d8b\u52bf\uff0c\u5728\u4e0d\u53d1\u8fbe\u56fd\u5bb6\u6216\u8005\u662f\u4e2d\u7b49\u53d1\u5c55\u56fd\u5bb6\u5b83\u7684\u6570\u636e\u589e\u9ad8\u5f97\u5f88\u660e\u663e\uff0c\u4f46\u76f8\u5bf9\u6765\u8bf4\uff0c\u5728\u897f\u65b9\u56fd\u5bb6\u7279\u522b\u662f\u7f8e\u56fd\u548c\u6b27\u6d32\u7b49\u53d1\u8fbe\u7684\u56fd\u5bb6\uff0c\u80ba\u764c\u53d1\u75c5\u7387\u57fa\u672c\u4e0a\u662f\u7a33\u5b9a\u6301\u5e73\uff0c\u751a\u81f3\u7565\u6709\u4e0b\u964d\uff0c\u8fd9\u548c\u9488\u5bf9\u9ad8\u5371\u4eba\u7fa4\u7684\u7b5b\u67e5\u4e0d\u65e0\u5173\u7cfb\u3002\u800c\u5728\u4e2d\u56fd\uff0c\u76ee\u524d\u7537\u6027\u60a3\u8005\u80ba\u764c\u7684\u53d1\u75c5\u7387\u7565\u6709\u4e0b\u964d\uff0c\u4f46\u5973\u6027\u60a3\u8005\u80ba\u764c\u7684\u53d1\u75c5\u7387\u5219\u6709\u6240\u63d0\u9ad8\u3002<\/p>\n


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\u3000\u3000\u610f\u5927\u5229\u90fd\u7075\uff08Turin\uff09\u5927\u5b66\u533b\u5b66\u80bf\u7624\u4e2d\u5fc3\u4e3b\u4efbGiorgio V.Scagliotti\u6559\u6388\u662f\u73b0\u4efb\u56fd\u9645\u80ba\u764c\u7814\u7a76\u5b66\u4f1a\u4e3b\u5e2d\uff0c\u4ed6\u8ba4\u4e3a\uff0c\u4e2d\u56fd\u4f5c\u4e3a\u80ba\u764c\u6700\u9ad8\u53d1\u7684\u56fd\u5bb6\uff0c\u5176\u80ba\u764c\u9632\u6cbb\u5173\u7cfb\u5230\u5168\u7403\u7684\u80ba\u764c\u9632\u63a7\u6c34\u5e73\u3002<\/p>\n


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\u3000\u3000\u5206\u5b50\u9776\u5411\u836f\u7269\u5bf9\u4e8e\u6709\u7279\u5b9a\u9a71\u52a8\u57fa\u56e0\u7a81\u53d8\u7684\u60a3\u8005\u5f88\u6709\u6548\uff0c\u4f46\u5bf9\u4e8e\u6ca1\u6709\u7a81\u53d8\u7684\u60a3\u8005\u6548\u679c\u5c31\u5f88\u5dee\u3002\u800c\u8fd9\u6279\u60a3\u8005\u5f80\u5f80\u4ecd\u7136\u53ea\u80fd\u4f9d\u8d56\u5316\u7597\u6765\u5ef6\u957f\u751f\u547d\uff0c\u4f46\u5316\u7597\u7684\u7597\u6548\u6709\u9650\uff0c\u800c\u4e14\u526f\u4f5c\u7528\u5927\u3002<\/p>\n


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\u3000\u3000\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u901a\u8fc7\u6fc0\u6d3b\u4eba\u4f53\u81ea\u8eab\u5bf9\u6297\u80bf\u7624\u7684\u514d\u75ab\u529f\u80fd\u6765\u6740\u6b7b\u80bf\u7624\u7ec6\u80de\uff0c\u6709\u7597\u6548\u6301\u4e45\uff0c\u526f\u4f5c\u7528\u76f8\u6bd4\u5316\u7597\u8981\u5c0f\u7684\u7279\u70b9\u3002\u5728\u67d0\u4e9b\u7624\u79cd\uff0c\u5982\u6076\u6027\u9ed1\u8272\u7d20\u7624\uff0c\u5176\u7597\u6548\u663e\u8457\uff0c\u90e8\u5206\u60a3\u8005\u751a\u81f3\u80fd\u5728\u505c\u836f\u540e\uff0c\u4ecd\u7136\u83b7\u5f97\u957f\u671f\u751f\u5b58\u3002<\/p>\n


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\u3000\u3000\u4f5c\u4e3a\u9996\u5c4a\u7531\u56fd\u9645\u80ba\u764c\u7814\u7a76\u534f\u4f1a\u9996\u6b21\u4e3b\u529e\u4e9a\u6d32\u80ba\u764c\u5927\u4f1a\uff0c\u81ea\u7136\u5438\u5f15\u4e86\u4e0d\u5c11\u5728\u80bf\u7624\u9886\u57df\u7814\u53d1\u9887\u6709\u6210\u5c31\u7684\u533b\u836f\u5de8\u5934\u51fa\u73b0\uff0c\u5305\u62ec\u4e86\u7f57\u6c0f\u3001\u8f89\u745e\u3001\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u3001\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u3001\u767e\u6d4e\u795e\u5dde\u3001\u4e9a\u76db\u533b\u836f\u3001\u6052\u745e\u533b\u836f\u7b49\u3002<\/p>\n


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FoundationOneCDx\u53ef\u5728\u80ba\u764c\u60a3\u8005\u4e2d\u68c0\u6d4b\u51fa\u66f4\u591a\u53ef\u5e72\u9884\u7684\u57fa\u56e0\u53d8\u5f02<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u3000\u3000\u5728\u4f1a\u4e0a\uff0c\u533b\u9662\u4e13\u5bb6\u8868\u793a\uff0c\u80ba\u764c\u6cbb\u7597\u5f88\u5927\u7a0b\u5ea6\u4e0a\u7531\u9776\u5411\u7597\u6cd5\u9a71\u52a8\u3002\u901a\u8fc7\u57fa\u56e0\u68c0\u6d4b\uff0c\u53ef\u4ee5\u786e\u5b9a\u60a3\u8005\u662f\u5426\u5b58\u5728\u9776\u70b9\u7a81\u53d8\uff0c\u624d\u53ef\u4ee5\u6839\u636e\u4e13\u4e1a\u7684\u5efa\u8bae\u4f7f\u7528\u4e0b\u4e00\u4ee3\u9776\u5411\u836f\u7269\u8fdb\u884c\u6cbb\u7597\u3002<\/p>\n


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\u3000\u3000FoundationOneCDx\u901a\u8fc7\u5bf9\u6bd4\u7814\u7a76\u53d1\u73b0\uff0c\u5176\u68c0\u6d4b\u654f\u611f\u6027\u66f4\u9ad8\uff0c\u53ef\u4ee5\u68c0\u6d4b\u51fa\u66f4\u591a\u7684\u57fa\u56e0\u7a81\u53d8\uff0c\u800c\u6d4b\u51fa\u6765\u7684\u5927\u90e8\u5206\u57fa\u56e0\u7a81\u53d8\u90fd\u53ef\u4ee5\u6709\u76f8\u5bf9\u5e94\u7684\u836f\u7269\u53bb\u6cbb\u7597\u5b83\u3002<\/p>\n


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\u3000\u3000FoundationOneCDx\u4f5c\u4e3aFDA\u6279\u51c6\u7684\u9996\u9879\u57fa\u4e8eNGS\u7684\u6cdb\u7624\u79cd\u8bca\u65ad\u670d\u52a1\u4ea7\u54c1\uff0c\u88ab\u8bc1\u5b9e\u53ef\u4ee5\u5728\u80ba\u764c\u60a3\u8005\u4e2d\u68c0\u6d4b\u51fa\u66f4\u591a\u53ef\u5e72\u9884\u7684\u57fa\u56e0\u53d8\u5f02\uff0c\u5305\u62ec\u4e86\u6240\u6709\u7c7b\u522b\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e34\u5e8a\u76f8\u5173\u7684\u53d8\u5f02\u3002\u5e7f\u6cdb\u7684\u5206\u5b50\u4fe1\u606f\u8c31\u5206\u6790\u5728\u764c\u75c7\u60a3\u8005\u4e2d\u7684\u5e94\u7528\u5df2\u7ecf\u4ea7\u751f\u79ef\u6781\u7684\u4e34\u5e8a\u6548\u679c\u3002\u5176\u5173\u952e\u4e34\u5e8a\u4f18\u52bf\u662f\u68c0\u6d4b\u51faNSCLC\u4e34\u5e8a\u76f8\u5173\u7684\u6240\u6709DNA\u53d8\u5f02\uff0c\u4f8b\u5982ALK\u3001EGFR\u3001BRAF\u3001ERBB2\u3001RET\u3001MET\u3001ROS1\u3001KRAS\u7b49\u7684\u56db\u79cdDNA\u53d8\u5f02\u7c7b\u578b\uff08\u70b9\u7a81\u53d8\/\u63d2\u5165\u6216\u7f3a\u5931\/\u91cd\u7ec4\u878d\u5408\/\u62f7\u8d1d\u6570\u6539\u53d8\uff09\u82e5NSCLC\u60a3\u8005\u6709\u7279\u5b9a\u7a81\u53d8\uff0cFoundationOneCDx\u68c0\u6d4b\u62a5\u544a\u4e2d\u53ef\u5217\u51fa\u9002\u7528\u4e8e\u8be5\u60a3\u8005\u7684\u7ecfFDA\u6279\u51c6\u7684\u9776\u5411\u7597\u6cd5\uff0c\u6bd4\u5982\uff1a\u514b\u5511\u66ff\u5c3c\u3001\u5384\u6d1b\u66ff\u5c3c\u3001\u5409\u975e\u66ff\u5c3c\u3001\u963f\u6cd5\u66ff\u5c3c\u3001\u5965\u897f\u66ff\u5c3c\u7b49\u3002<\/p>\n


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\u4e00\u7ebf\u963f\u6cd5\u66ff\u5c3c\u8fdb\u5c55\u540e\u4f7f\u7528\u5965\u5e0c\u66ff\u5c3c\u6cbb\u7597\u663e\u793a\u8d85\u957f\u751f\u5b58\u83b7\u76ca<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u3000\u3000\u5728\u536b\u661f\u4f1a\u4e0a\uff0c\u6765\u81ea\u4e2d\u5c71\u5927\u5b66\u9644\u5c5e\u80bf\u7624\u533b\u9662\u7684\u4e13\u5bb6\u5206\u4eab\u4e86\u963f\u6cd5\u66ff\u5c3c\u6cbb\u7597\u540e\u4f7f\u7528\u5965\u5e0c\u66ff\u5c3c\u7684\u771f\u5b9e\u4e16\u754c\u7814\u7a76\u7ed3\u679c\u3002<\/p>\n


<\/p>\n

\u3000\u3000\u6700\u65b0\u516c\u5e03\u7684GioTag\u7814\u7a76\u662f\u4e00\u9879\u771f\u5b9e\u4e16\u754c\u56de\u987e\u6027\u7814\u7a76\uff0c\u65e8\u5728\u7814\u7a76\u5728\u4e00\u7ebf\u963f\u6cd5\u66ff\u5c3c\u6cbb\u7597\u540e\u4f7f\u7528\u5965\u5e0c\u66ff\u5c3c\uff0c\u5bf9\u4e8e\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53\u7a81\u53d8\u9633\u6027\uff08EGFR M+\uff09\u5e76\u5e26\u6709\u83b7\u5f97\u6027T790M\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u7597\u6548\u3002<\/p>\n


<\/p>\n

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\u514b\u5511\u66ff\u5c3c\u5e8f\u8d2f\u4e8c\u4ee3ALK\u6291\u5236\u5242\u5e26\u6765\u751f\u5b58\u5947\u8ff9<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u3000\u3000\u7f8e\u56fdFDA\u65e5\u524d\u6279\u51c6\u8f89\u745e\u7814\u53d1\u7684\u7b2c\u4e09\u4ee3ALK\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff08TKI\uff09Lorbrena\uff08lorlatinib\uff09\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597ALK\u9633\u6027\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u3002<\/p>\n


<\/p>\n

\u3000\u3000\u968f\u7740\u4e3a\u514b\u670d\u4e00\u4ee3ALK\u6291\u5236\u5242\u8010\u836f\u95ee\u9898\u7684\u4e8c\u4ee3ALK\u6291\u5236\u5242\u8fdb\u5165\u4e34\u5e8a\u3001\u4e09\u4ee3ALK\u6291\u5236\u5242\u5c55\u73b0\u51fa\u5353\u8d8a\u7684\u7597\u6548\uff0cALK\u9633\u6027\u665a\u671fNSCLC\u5168\u7a0b\u7ba1\u7406\u7406\u5ff5\uff0c\u5728\u8f89\u745e\u536b\u661f\u4f1a\u4e0a\u5f97\u5230\u4f17\u591a\u4f1a\u4e13\u5bb6\u8ba4\u53ef\u3002<\/p>\n


<\/p>\n

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<\/p>\n

\u25a0\u90d1\u83b9\u83b9 \u674e\u8574\u660e \u5218\u5349<\/span><\/strong><\/p>\n

\u25a0\u7f16\u8f91 \u9648\u96ea\u8587<\/span><\/strong><\/span><\/strong><\/p>\n


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