{"id":72497,"date":"2018-10-18T01:00:00","date_gmt":"2018-12-07T05:06:41","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/41c6dc5013\/"},"modified":"2018-12-07T13:06:42","modified_gmt":"2018-12-07T05:06:42","slug":"41c6dc5013","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/72497\/","title":{"rendered":"\u56fd\u4ea7PD-1\u6216\u660e\u5e74\u4e0a\u5e02 \u4fe1\u8fbe\u751f\u7269\u8d74\u6e2fIPO\u80fd\u5426\u89e3\u201c\u7834\u53d1\u9b54\u5492\u201d?"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"text-align: center;\"><img class=\"__bg_gif\"         width=\"auto\" style=\"text-align: center;white-space: normal;color: rgb(62, 62, 62);font-family: \u5fae\u8f6f\u96c5\u9ed1;z-index: -1;cursor: pointer;font-size: 14px;line-height: 22.4px;background-color: rgb(255, 255, 255);width: 558px;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/6-1544159202.jpeg\" alt=\"\u56fd\u4ea7PD-1\u6216\u660e\u5e74\u4e0a\u5e02 \u4fe1\u8fbe\u751f\u7269\u8d74\u6e2fIPO\u80fd\u5426\u89e3\u201c\u7834\u53d1\u9b54\u5492\u201d?\" title=\"\u56fd\u4ea7PD-1\u6216\u660e\u5e74\u4e0a\u5e02 \u4fe1\u8fbe\u751f\u7269\u8d74\u6e2fIPO\u80fd\u5426\u89e3\u201c\u7834\u53d1\u9b54\u5492\u201d?\"  \/><\/p>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<p>\u3000\u3000\u4fe1\u8fbe\u751f\u7269\u4eca\u65e5\uff0810\u670818\u65e5\uff09\u8d77\u5728\u9999\u6e2f\u516c\u5f00\u62db\u80a1\uff0c\u9884\u8ba110\u670831\u65e5\u6302\u724c\u4e0a\u5e02\uff0c\u5c06\u6210\u4e3a\u7b2c\u56db\u5bb6\u5728\u6e2f\u4e0a\u5e02\u7684\u672a\u76c8\u5229\u751f\u7269\u533b\u836f\u516c\u53f8\u3002\u540c\u65e5\uff0c\u4fe1\u8fbe\u751f\u7269\u5ba3\u5e03\u5176\u81ea\u4e3b\u5f00\u53d1\u7684\u91cd\u7ec4\u5168\u4eba\u6e90\u6297\u7ec6\u80de\u6bd2T\u6dcb\u5df4\u7ec6\u80de\u76f8\u5173\u6297\u539f-4\uff08CTLA-4\uff09\u5355\u514b\u9686\u6297\u4f53\uff08\u7814\u53d1\u4ee3\u53f7IBI310\uff09\uff0c\u2160\u671f\u4e34\u5e8a\u7814\u7a76\u5df2\u7ecf\u5b8c\u6210\u9996\u4f8b\u60a3\u8005\u7ed9\u836f\u3002<\/p>\n<p>\u3000\u3000\u3000\u3000<\/p>\n<section class=\"_135editor\"     style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"135brush\" style=\"border-left: 5px solid #ef7060;font-weight: bold;line-height: 32px;color: #666666;padding: 5px 10px;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 16px;\"><strong style=\"caret-color: red;\"><span style=\"color: #ef7060;font-size: 18px;\">PD-1\u6297\u4f53\u987a\u5229\u4e0a\u5e02\u53ef\u63d0\u632f\u4fe1\u5fc3<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<p>\u3000\u3000<br  \/><\/p>\n<p>\u3000\u3000\u6309\u7167IPO\u8ba1\u5212\uff0c\u4fe1\u8fbe\u751f\u7269\u6b64\u6b21\u5c06\u53d1\u884c\u7ea62.36\u4ebf\u80a1\uff0c\u76f8\u5f53\u4e8e\u4e0a\u5e02\u540e\u603b\u6d41\u901a\u80a1\u672c21.1%\uff0c\u5176\u4e2d\u9999\u6e2f\u516c\u5f00\u53d1\u884c\u6bd4\u4f8b\u7ea610%\uff0c\u56fd\u9645\u914d\u552e\u6bd4\u4f8b\u4e3a90%\u3002\u5176\u4e2d\uff0c\u4e0a\u5e02\u96c6\u8d44\u91d1\u989d\u768465%\u7528\u4e8e\u6838\u5fc3\u4ea7\u54c1\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3001\u6ce8\u518c\u5907\u6848\u53ca\u8ba1\u5212\u7684\u5546\u4e1a\u5316\u63a8\u51fa\uff0c25%\u7528\u4e8e\u5176\u4ed6\u7ba1\u7ebf\u5019\u9009\u836f\u7269\uff0c10%\u5219\u7528\u4f5c\u8425\u8fd0\u8d44\u91d1\u53ca\u4e00\u822c\u516c\u53f8\u7528\u9014\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u81ea\u6e2f\u80a1\u5e02\u573a\u5141\u8bb8\u5c1a\u672a\u76c8\u5229\u7684\u751f\u7269\u79d1\u6280\u516c\u53f8\u4e0a\u5e02\u540e\uff0c\u6b4c\u793c\u751f\u7269\u3001\u767e\u6d4e\u795e\u5dde\u548c\u534e\u9886\u533b\u836f\u9646\u7eed\u6210\u529f\u4e0a\u5e02\u3002\u7136\u800c\u5728\u4eca\u5e74\u6e2f\u80a1\u5e02\u573a\u65b0\u80a1\u7834\u53d1\u7387\u572870%\u4ee5\u4e0a\u7684\u5927\u80cc\u666f\u4e0b\uff0c\u4e0a\u8ff03\u5bb6\u4f01\u4e1a\u5747\u51fa\u73b0\u7834\u53d1\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u5e02\u573a\u4eba\u58eb\u6307\u51fa\uff0c\u4fe1\u8fbe\u751f\u7269\u81ea\u6210\u7acb\u4ee5\u6765\u7684\u5404\u5e74\u5ea6\u5185\u5747\u672a\u80fd\u76c8\u5229\uff0c\u5e76\u4ea7\u751f\u7ecf\u8425\u4e8f\u635f\uff0c\u4f46\u7531\u4e8e\u7edd\u5927\u90e8\u5206\u7ecf\u8425\u4e8f\u635f\u662f\u7814\u53d1\u5f00\u652f\u3001\u884c\u653f\u5f00\u652f\u3001\u4e1a\u52a1\u53d1\u5c55\u5f00\u652f\u53ca\u878d\u8d44\u6210\u672c\u6240\u81f4\uff0c\u201c\u82e5\u5176\u6838\u5fc3\u4ea7\u54c1\u4fe1\u8fea\u5229\u5355\u6297\u80fd\u5728\u660e\u5e74\u987a\u5229\u63a8\u51fa\uff0c\u5c06\u80fd\u5feb\u901f\u5316\u89e3\u5e02\u573a\u62c5\u5fe7\u60c5\u7eea\u3002\u201d<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u6709\u5206\u6790\u8ba4\u4e3a\uff0c\u4fe1\u8fbe\u751f\u7269\u62ab\u9732\u7684\u57fa\u77f3\u6295\u8d44\u8005\u9635\u5bb9\u4e5f\u662f\u5e02\u573a\u4fe1\u5fc3\u7684\u652f\u6491\u70b9\u4e4b\u4e00\u3002\u6b64\u524d\u62ab\u9732\u768410\u540d\u57fa\u77f3\u6295\u8d44\u8005\uff0c\u603b\u8ba1\u8ba4\u8d2d2.45\u4ebf\u7f8e\u5143\uff0c\u5360\u96c6\u8d44\u91d1\u989d\u8d85\u8fc760%\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u4fe1\u8fbe\u751f\u7269\u9996\u5e2d\u8d22\u52a1\u5b98\u595a\u6d69\u65e5\u524d\u4e5f\u5766\u8a00\uff0c\u9009\u62e9\u5728\u9999\u6e2f\u4e0a\u5e02\u7684\u539f\u56e0\u4e4b\u4e00\u5728\u4e8e\u9999\u6e2f\u5e02\u573a\u5341\u5206\u56fd\u9645\u5316\uff0c\u80fd\u5438\u5f15\u7f8e\u56fd\u5728\u5185\u7684\u56fd\u9645\u6295\u8d44\u8005\uff0c\u4e5f\u6709\u5229\u4e8e\u5185\u5730\u5728\u5185\u7684\u4e9a\u592a\u533a\u6295\u8d44\u8005\u53c2\u4e0e\u3002<\/p>\n<p>\u3000\u3000\u3000\u3000<\/p>\n<section class=\"_135editor\"     style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"135brush\" style=\"border-left: 5px solid #ef7060;font-weight: bold;line-height: 32px;color: #666666;padding: 5px 10px;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<p style=\"line-height: 1.5em;\"><span style=\"font-size: 16px;\"><strong style=\"caret-color: red;\"><span style=\"color: #ef7060;font-size: 18px;\">\u56db\u5927\u91cd\u78c5\u5728\u7814\u836f\u7269\u8fdb\u5165\u540e\u671f\u4e34\u5e8a<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<p>\u3000\u3000<br  \/><\/p>\n<p>\u3000\u3000\u5c3d\u7ba1\u5206\u6790\u4eba\u58eb\u5bf9\u4fe1\u8fbe\u751f\u7269\u80fd\u5426\u89e3\u201c\u7834\u53d1\u9b54\u5492\u201d\u4e0d\u751a\u4e50\u89c2\uff0c\u4f46\u4e5f\u5747\u8ba4\u53ef\u4fe1\u8fbe\u751f\u7269\u5728\u4e2d\u957f\u671f\u5177\u6709\u7684\u7206\u53d1\u6027\u589e\u957f\u6f5c\u529b\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u5176\u4f9d\u636e\u662f\u4fe1\u8fbe\u751f\u7269\u76ee\u524d\u5df2\u5efa\u7acb\u7684\u753117\u79cd\u6297\u4f53\u5019\u9009\u836f\u7269\u7ec4\u6210\u7684\u4ea7\u54c1\u7814\u53d1\u7ba1\u7ebf\u3002\u5176\u4e2d\u65b0\u578b\u7684PD-1\u6297\u4f53\u4fe1\u8fea\u5229\u5355\u6297(IBI-308)\u3001\u8d1d\u4f10\u73e0\u5355\u6297\uff08\u963f\u74e6\u65af\u6c40\uff09\u7684\u751f\u7269\u7c7b\u4f3c\u836fIBI-305\u3001\u5229\u59a5\u6614\u5355\u6297(\u7f8e\u7f57\u534e \/Rituxan)\u7684\u751f\u7269\u7c7b\u4f3c\u836fIBI-301\u548c\u963f\u8fbe\u6728\u5355\u6297\uff08\u4fee\u7f8e\u4e50\uff09\u7684\u751f\u7269\u7c7b\u4f3c\u836fIBI-303\u8fd9\u56db\u79cd\u6838\u5fc3\u4ea7\u54c1\u5df2\u56fd\u5185\u8fdb\u5165\u540e\u671f\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/1-1544159202.jpeg\" alt=\"\u56fd\u4ea7PD-1\u6216\u660e\u5e74\u4e0a\u5e02 \u4fe1\u8fbe\u751f\u7269\u8d74\u6e2fIPO\u80fd\u5426\u89e3\u201c\u7834\u53d1\u9b54\u5492\u201d?\" title=\"\u56fd\u4ea7PD-1\u6216\u660e\u5e74\u4e0a\u5e02 \u4fe1\u8fbe\u751f\u7269\u8d74\u6e2fIPO\u80fd\u5426\u89e3\u201c\u7834\u53d1\u9b54\u5492\u201d?\"  \/><\/p>\n<p style=\"text-align: right;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\u6765\u6e90\uff1a\u4fe1\u8fbe\u751f\u7269\u62db\u80a1\u8bf4\u660e\u4e66<\/span><\/p>\n<p><br  \/><\/p>\n<p>\u3000\u3000\u800c\u4fe1\u8fbe\u751f\u7269\u65b9\u9762\u4e5f\u8868\u793a\uff0c\u4e1a\u52a1\u53ca\u7ecf\u8425\u4e1a\u7ee9\u53d6\u51b3\u4e8e\u4f01\u4e1a\u5c06\u5019\u9009\u836f\u7269\u5546\u4e1a\u5316\u7684\u80fd\u529b\u3002\u76ee\u524d\u4fe1\u8fbe\u751f\u7269\u62e5\u6709\u4e30\u5bcc\u7684\u5019\u9009\u836f\u7269\u7ba1\u7ebf\uff0c\u5305\u62ec\u516d\u79cd\u5904\u4e8e\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u7684\u5019\u9009\u836f\u7269\u3001\u56db\u79cd\u5904\u4e8eIND\u7533\u8bf7\u9636\u6bb5\u7684\u5019\u9009\u836f\u7269\u53ca\u4e03\u79cd\u5904\u4e8e\u4e34\u5e8a\u524d\u5f00\u53d1\u9636\u6bb5\u7684\u5019\u9009\u836f\u7269\u3002\u5c3d\u7ba1\u76ee\u524d\u5c1a\u672a\u6709\u4ea7\u54c1\u83b7\u5f97\u5546\u4e1a\u9500\u552e\u6279\u51c6\uff0c\u4e14\u4ea7\u54c1\u9500\u552e\u5c1a\u672a\u4ea7\u751f\u4efb\u4f55\u6536\u5165\uff0c\u4f46\u9884\u671f\u5c06\u4e8e\u672a\u6765\u51e0\u5e74\uff0c\u5728\u4e00\u79cd\u6216\u591a\u79cd\u5019\u9009\u836f\u7269\u8fdb\u5165\u5f00\u53d1\u7684\u6700\u540e\u9636\u6bb5\u65f6\u5c06\u4e4b\u5546\u4e1a\u5316\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u76ee\u524d\u201c\u6709\u671b\u6210\u4e3a\u540c\u7c7b\u4e2d\u6700\u4f73\u7684\u521b\u65b0\u6027PD-1\u5355\u514b\u9686\u6297\u4f53\u201d\uff08\u62db\u80a1\u8bf4\u660e\u4e66\u8bed\uff09\u7684\u65b0\u578b\u7684PD-1\u6297\u4f53\u4fe1\u8fea\u5229\u5355\u6297(IBI-308)\u662f\u4fe1\u8fbe\u751f\u7269\u6700\u63a5\u8fd1\u5546\u4e1a\u5316\u7684\u5019\u9009\u836f\u7269\u3002\u4f5c\u4e3a\u4e00\u79cd\u521b\u65b0\u7684\u5168\u4eba\u6e90PD-1\u5355\u514b\u9686\u6297\u4f53\uff0c\u4fe1\u8fea\u5229\u5355\u6297\u4e0a\u5e02\u7533\u8bf7\u5df2\u4e8e\u4eca\u5e744\u6708\u88ab\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6b63\u5f0f\u53d7\u7406\uff0c\u5e76\u4e8e4\u670823\u65e5\u5c06\u5176\u5217\u5165\u4f18\u5148\u5ba1\u8bc4\u54c1\u79cd\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u6b64\u6b21\u4fe1\u8fbe\u751f\u7269\u4e0a\u5e02\u96c6\u8d44\u91d1\u989d\u768452%\u5c06\u7528\u4e8e\u4fe1\u8fea\u5229\u5355\u6297\u4e34\u5e8a\u8bd5\u9a8c\u3001\u6ce8\u518c\u5907\u6848\u7684\u51c6\u5907\u4e8b\u5b9c\u53ca\u8ba1\u5212\u7684\u5546\u4e1a\u5316\u63a8\u51fa\uff08\u5305\u62ec\u9500\u552e\u53ca\u5e02\u573a\u63a8\u5e7f\uff09\u3002<\/p>\n<p>\u3000\u3000<\/p>\n<p>\u3000\u3000\u636e\u6089\uff0c\u4fe1\u8fbe\u751f\u7269\u6b63\u8ba1\u5212\u901a\u8fc7\u63a2\u7d22\u66f4\u591a\u9002\u5e94\u75c7\uff08\u5982\u809d\u7ec6\u80de\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u80be\u7ec6\u80de\u764c\u548c\u5987\u79d1\u764c\u75c7\u7b49\uff09\u6765\u6700\u5927\u5316PD-1\u6297\u4f53\u4fe1\u8fea\u5229\u5355\u6297\u7684\u5546\u4e1a\u6f5c\u529b\uff0c\u6b63\u5728\u5f00\u53d1\u4fe1\u8fea\u5229\u5355\u6297\u4f5c\u4e3a\u590d\u53d1\/\u96be\u6cbb\u7ecf\u5178\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u3001\u4e00\u7ebf\u53ca\u4e8c\u7ebf\u9ed1\u7d20\u7624\u3001\u80c3\u80a0\u764c\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u4e8c\u7ebf\u98df\u9053\u764c\u3001\u4e8c\u7ebf\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u548cNK\/T 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style=\"text-align: center;margin: 30px 0% 10px;box-sizing: border-box;\">\n<section style=\"display: inline-block;width: 95%;vertical-align: top;box-shadow: #b9b9b9 1.41421px 1.41421px 6px 0px;padding: 5px;box-sizing: border-box;\" >\n<section>\n<section style=\"margin: -20px 0% 5px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-shadow: #000000 0px 0px 0px 0px;box-sizing: border-box;overflow: hidden !important;\"><img class=\"\"     style=\"vertical-align: middle;box-sizing: border-box;width: auto;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/2-1544159202.png\" alt=\"\u56fd\u4ea7PD-1\u6216\u660e\u5e74\u4e0a\u5e02 \u4fe1\u8fbe\u751f\u7269\u8d74\u6e2fIPO\u80fd\u5426\u89e3\u201c\u7834\u53d1\u9b54\u5492\u201d?\" title=\"\u56fd\u4ea7PD-1\u6216\u660e\u5e74\u4e0a\u5e02 \u4fe1\u8fbe\u751f\u7269\u8d74\u6e2fIPO\u80fd\u5426\u89e3\u201c\u7834\u53d1\u9b54\u5492\u201d?\"  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10px;box-sizing: border-box;\">\n<section style=\"display: inline-block;box-shadow: #ef7060 0px 0px 0px 0px inset;border-style: solid;border-width: 1px;border-radius: 10%;border-color: #424242;padding: 5px;background-color: #ef7060;box-sizing: border-box;color: #ffffff;\">\n<section>\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: left;color: #ef7060;padding-right: 8px;padding-left: 8px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><span style=\"color: #ffffff;font-size: 14px;\"><strong style=\"box-sizing: border-box;\" class=\"135brush\" ><span style=\"font-family: Optima-Regular, PingFangTC-light;box-sizing: border-box;\">\u626b\u7801\u52a0\u5c0f\u7f16<\/span><\/strong><\/span><\/p>\n<p style=\"box-sizing: border-box;text-align: center;\"><span style=\"color: #ffffff;font-size: 14px;\"><strong style=\"box-sizing: border-box;\" class=\"135brush\" ><span style=\"font-family: Optima-Regular, PingFangTC-light;box-sizing: border-box;\">\u9080\u4f60\u5165\u7fa4<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-bottom: 10px;font-size: 16px;white-space: normal;line-height: 25.6px;max-width: 100%;min-height: 1em;color: rgb(62, 62, 62);background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"margin-bottom: 10px;font-size: 16px;white-space: normal;line-height: 25.6px;max-width: 100%;min-height: 1em;color: rgb(62, 62, 62);background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;line-height: 1.6;white-space: pre-wrap;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/span><strong style=\"max-width: 100%;line-height: 25.6px;text-align: center;box-sizing: border-box 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