{"id":7279,"date":"2018-06-12T01:00:00","date_gmt":"2018-07-27T09:22:26","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e5%8f%a3%e6%9c%8d%e7%b4%a2%e9%a9%ac%e9%b2%81%e8%82%bdiii%e6%9c%9f%e4%b8%b4%e5%ba%8a%e6%a8%aa%e6%89%absglt-2-dpp-4-%e5%8f%a3%e6%9c%8dglp-1%e9%99%8d%e7%b3%96%e4%b8%8d%e5%86%8d%e6%98%af\/"},"modified":"2018-07-27T17:22:31","modified_gmt":"2018-07-27T09:22:31","slug":"%e5%8f%a3%e6%9c%8d%e7%b4%a2%e9%a9%ac%e9%b2%81%e8%82%bdiii%e6%9c%9f%e4%b8%b4%e5%ba%8a%e6%a8%aa%e6%89%absglt-2-dpp-4-%e5%8f%a3%e6%9c%8dglp-1%e9%99%8d%e7%b3%96%e4%b8%8d%e5%86%8d%e6%98%af","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/7279\/","title":{"rendered":"\u53e3\u670d\u7d22\u9a6c\u9c81\u80bdIII\u671f\u4e34\u5e8a\u6a2a\u626bSGLT-2\/DPP-4\u2014\u2014\u53e3\u670dGLP-1\u964d\u7cd6\u4e0d\u518d\u662f\u68a6"},"content":{"rendered":"
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\u70b9\u51fb\u4e0a\u65b9\u7684 \u884c\u821fDrug <\/span>\u25b2 \u6dfb\u52a0\u5173\u6ce8<\/span><\/span><\/p>\n


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2018\u5e742\u670822\u65e5\uff0c\u8bfa\u548c\u8bfa\u5fb7\u5ba3\u5e03\u4e86\u53e3\u670d\u7d22\u9a6c\u9c81\u80bd\uff08GLP-1\u7c7b\u4f3c\u7269\uff09\u6cbb\u75972\u578b\u7cd6\u5c3f\u75c5\u7684\u9996\u4e2aIIIa\u671fPIONEER 1\u7814\u7a76\u7684\u4e00\u7ebf\u7ed3\u679c\u3002PIONEER 1\u7814\u7a76\u5165\u7ec4703\u4f8b2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\uff0c\u91c7\u7528\u968f\u673a\u5e73\u884c\u5206\u7ec4\uff0c\u6bd4\u8f83\u53e3\u670d\u7d22\u9a6c\u9c81\u80bd3\uff0c 7\uff0c 14mg\u6bcf\u65e51\u6b21\u4e0e\u5b89\u6170\u5242\u5728\u7b2c26\u5468\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u5dee\u5f02\u3002<\/span><\/p>\n


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\u7ed3\u679c\u663e\u793a\uff0c\u6309\u7167\u9996\u8981\u7edf\u8ba1\u539f\u5219\uff0cPIONEER 1\u7814\u7a76\u5230\u8fbe\u4e86\u4e3b\u8981\u7ec8\u70b9\uff0c\u53e3\u670d3\u79cd\u4e0d\u540c\u5242\u91cf\u7d22\u9a6c\u9c81\u80bd\u76f8\u6bd4\u5b89\u6170\u5242\u5747\u53ef\u4ee5\u663e\u8457\u964d\u4f4eHbA1c\u6c34\u5e73\uff0c\u4e1414mg\u5242\u91cf\u7ec4\u76f8\u6bd4\u5b89\u6170\u5242\u8fd8\u6709\u660e\u663e\u7684\u51cf\u91cd\u4f5c\u7528\u3002<\/span><\/p>\n

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\"\u53e3\u670d\u7d22\u9a6c\u9c81\u80bdIII\u671f\u4e34\u5e8a\u6a2a\u626bSGLT-2\/DPP-4\u2014\u2014\u53e3\u670dGLP-1\u964d\u7cd6\u4e0d\u518d\u662f\u68a6\"<\/p>\n

2018\u5e745\u670829\u65e5\u8bfa\u548c\u8bfa\u5fb7<\/span>\u5ba3\u5e03\u4e86\u53e3\u670d\u7d22\u9a6c\u9c81\u80bd\u6cbb\u75972\u578b\u7cd6\u5c3f\u75c5\u7684\u7b2c2\u9879IIIa\u671f\u7814\u7a76\uff08PIONEER 2\uff09\u7684\u5173\u952e\u7ed3\u679c\u3002<\/span><\/p>\n


<\/span><\/p>\n

PIONEER 2\u662f\u4e00\u9879\u4e3a\u671f52\u5468\u7684\u5f00\u653e\u6807\u7b7e\u3001\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u5e73\u884c\u5206\u7ec4\u3001\u9633\u6027\u5bf9\u7167\u7814\u7a76\uff0c\u5728816\u4f8b\u4e8c\u7532\u53cc\u80cd\u63a7\u5236\u8840\u7cd6\u4e0d\u8fbe\u6807\u7684\u60a3\u8005\u4e2d\u8bc4\u4f30\u4e86\u6bcf\u65e51\u6b21\u53e3\u670d\u7d22\u9a6c\u9c81\u80bd14mg\u548c\u6069\u683c\u5217\u51c025mg\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u5dee\u5f02\u3002\u4e3b\u8981\u7ec8\u70b9\u662f26\u5468\u65f6HbA1c\u6c34\u5e73\u548c\u4f53\u91cd\u8f83\u57fa\u7ebf\u7684\u53d8\u5316\uff0c\u6b21\u8981\u91cd\u70b9\u662f52\u5468\u65f6HbA1c\u6c34\u5e73\u548c\u4f53\u91cd\u8f83\u57fa\u7ebf\u7684\u53d8\u5316\u3002<\/span><\/p>\n


<\/p>\n

\u7ed3\u679c\u663e\u793a\uff0c\u6309\u7167\u9996\u8981\u7edf\u8ba1\u539f\u5219\uff0cPIONEER 2\u7814\u7a76\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\uff0c\u7b2c26\u5468\u65f6\uff0c\u53e3\u670d\u7d22\u9a6c\u9c81\u80bd\u964d\u4f4eHbA1c\u7684\u4f5c\u7528\u663e\u8457\u4f18\u4e8e\u6069\u683c\u5217\u51c0\uff0c\u4f46\u4e24\u7ec4\u60a3\u8005\u7684\u4f53\u91cd\u51cf\u8f7b\u6548\u679c\u65e0\u663e\u8457\u5dee\u5f02\u3002<\/span><\/p>\n

<\/span><\/p>\n

\"\u53e3\u670d\u7d22\u9a6c\u9c81\u80bdIII\u671f\u4e34\u5e8a\u6a2a\u626bSGLT-2\/DPP-4\u2014\u2014\u53e3\u670dGLP-1\u964d\u7cd6\u4e0d\u518d\u662f\u68a6\"<\/p>\n

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\u53e3\u670d\u7d22\u9a6c\u9c81\u80bd\u5168\u7403\u9500\u91cf\u9884\u6d4b<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


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\u53e3\u670d\u7d22\u9a6c\u9c81\u80bd\uff1aEligen\u00ae\u6280\u672f\u662f\u6838\u5fc3<\/span><\/strong><\/span><\/p>\n<\/blockquote>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
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<\/p>\n

\u7d22\u9a6c\u9c81\u80bd\u662f\u4e00\u79cdGLP-1\u7c7b\u4f3c\u7269\uff0c\u591a\u80bd\uff0c\u7f18\u4f55\u80fd\u591f\u53e3\u670d\uff0c\u8fd9\u91cc\u4e0d\u5f97\u4e0d\u63d0\u53ca\u4e00\u5bb6\u516c\u53f8\u2014\u2014Emisphere\uff0cPIONEER I\u4fbf\u662f\u8fd9\u6b21\u6700\u65e9\u516c\u5e03\u7684\u4e00\u4e2a\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"\u53e3\u670d\u7d22\u9a6c\u9c81\u80bdIII\u671f\u4e34\u5e8a\u6a2a\u626bSGLT-2\/DPP-4\u2014\u2014\u53e3\u670dGLP-1\u964d\u7cd6\u4e0d\u518d\u662f\u68a6\"<\/p>\n


<\/p>\n

2008\u5e746\u6708\uff0c\u8bfa\u548c\u8bfa\u5fb7\u548cEmisphere\u516c\u53f8\u7b7e\u8ba2\u5408\u4f5c\u534f\u8bae\uff0cEmisphere\u516c\u53f8\u5c06\u6388\u6743\u8bfa\u548c\u8bfa\u5fb7\u4f7f\u7528Eligen\u00ae\u6280\u672f\u5f00\u53d1GLP-1\u7c7b\u4f3c\u7269\u53e3\u670d\u5236\u5242\uff0c\u8bfa\u548c\u8bfa\u5fb7\u56e0\u6b64\u542f\u52a8\u4e86PIONEER\u9879\u76ee\uff0c\u6d89\u53ca10\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8ba1\u5212\u62db\u52df9600\u540d\u60a3\u8005\u3002<\/span><\/p>\n


<\/p>\n

\n

\u6240\u4ee5\uff0cEligen\u00ae\u6280\u672f\u5230\u5e95\u662f\u4ec0\u4e48\uff1f<\/strong><\/span><\/p>\n<\/blockquote>\n


<\/p>\n

Eligen\u00ae\u6280\u672f\u8bf4\u767d\u4e86\u5c31\u662f\u57fa\u4e8e\u5404\u79cd\u4fc3\u5438\u6536\u5242\u7684\u5927\u5206\u5b50\u9012\u9001\u6280\u672f\uff0c\u6280\u672f\u7684\u5173\u952e\u5728\u4e8e\u4fc3\u5438\u6536\u5242\u7684\u8bbe\u8ba1\u548c\u5f00\u53d1\uff0c\u8fd9\u91cc\u7528\u5230\u7684\u4fc3\u5438\u6536\u5242\u662fSNAC\uff088-(2-\u7f9f\u57fa\u82ef\u7532\u9170\u80fa\u57fa)\u8f9b\u9178\u94a0\uff09\u3002<\/span><\/p>\n

\"\u53e3\u670d\u7d22\u9a6c\u9c81\u80bdIII\u671f\u4e34\u5e8a\u6a2a\u626bSGLT-2\/DPP-4\u2014\u2014\u53e3\u670dGLP-1\u964d\u7cd6\u4e0d\u518d\u662f\u68a6\"<\/p>\n

SNAC\u80fd\u591f\u4e0e\u5927\u5206\u5b50\u901a\u8fc7\u4ee5\u5f31\u7684\u5206\u5b50\u95f4\u76f8\u4e92\u4f5c\u7528\u76f8\u4e92\u7ed3\u5408\uff0c\u5927\u5206\u5b50\u836f\u7269\u88ab\u591a\u4e2aSNAC\u5206\u5b50\u201c\u5305\u88f9\u201d\uff0c\u5916\u90e8\u6781\u6027\u5c0f\u3001\u5185\u90e8\u6781\u6027\u5927\uff0c\u5f62\u6210\u8102\u8d28\u4f53\u7ed3\u6784\uff0c\u819c\u901a\u900f\u6027\u5177\u6709\u4e00\u5b9a\u7a0b\u5ea6\u7684\u63d0\u9ad8\uff0c\u80fd\u591f\u9012\u90010.5kd-150kd\u7684\u5927\u5206\u5b50\u3002\u8fc7\u7a0b\u4e2d\uff0c\u4e0d\u5f71\u54cd\u5927\u5206\u5b50\u7684\u9ad8\u7ea7\u7ed3\u6784\uff0c\u4e0d\u5f71\u54cd\u836f\u7269\u91ca\u653e\uff0cSNAC\u5177\u6709\u5f88\u9ad8\u5b89\u5168\u6027\uff0c\u4e0d\u5f71\u54cd\u80c3\u80a0\u9ecf\u819c\u7ed3\u6784\u3002<\/span><\/p>\n

 <\/p>\n

\"\u53e3\u670d\u7d22\u9a6c\u9c81\u80bdIII\u671f\u4e34\u5e8a\u6a2a\u626bSGLT-2\/DPP-4\u2014\u2014\u53e3\u670dGLP-1\u964d\u7cd6\u4e0d\u518d\u662f\u68a6\"<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u7d22\u9a6c\u9c81\u80bd\uff1a\u53e3\u670d VS \u6ce8\u5c04<\/span><\/strong><\/span><\/p>\n<\/blockquote>\n


<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u770b\u8fc7\u4e0a\u6587\uff0cEligen\u00ae\u6280\u672f\u4f3c\u4e4e\u5e76\u6ca1\u6709\u4ec0\u4e48\u795e\u79d8\uff0c8-(2-\u7f9f\u57fa\u82ef\u7532\u9170\u80fa\u57fa)\u8f9b\u9178\u94a0\u4e5f\u5e76\u6ca1\u6709\u4ec0\u4e48\u5408\u6210\u96be\u5ea6\uff0cEligen\u00ae\u6280\u672f\u867d\u7136\u4e0d\u53ef\u5426\u5b9a\uff0c\u4f46\u662f\uff0cSNAC\u5e76\u4e0d\u4e00\u5b9a\u9002\u5408\u6240\u6709\u7684\u5927\u5206\u5b50\u836f\u7269\uff0c\u7d22\u9a6c\u9c81\u80bd\u5c5e\u76f8\u5bf9\u7a33\u5b9a\u7684\u5927\u5206\u5b50\uff0c\u6362\u4e00\u4e2a\u77eb\u60c5\u7684\u5927\u5206\u5b50\uff0c\u7ed3\u679c\u5c31\u4e0d\u4e00\u5b9a\u4e86\u3002<\/span><\/p>\n


<\/p>\n

\u53e6\u5916\uff0c\u4e0d\u53ef\u5ffd\u89c6\u7684\u662f\u5df2\u4e0a\u5e02\u7d22\u9a6c\u9c81\u80bd\u6bcf\u5468\u7528\u836f\u4e00\u6b21\uff0c\u6bcf\u94880.25-1.0mg\uff08\u8d77\u59cb4\u5468\uff0c\u6bcf\u6b210.25mg\uff0c\u4e4b\u540e\u589e\u81f30.5-1.0mg\/\u6b21\uff09\uff0c\u800c\u53e3\u670d\u662f\u4e00\u5929\u4e00\u7247\uff0c\u6bcf\u724710-20mg\u3002\u751f\u7269\u5229\u7528\u5ea6\u8fd8\u662f\u4e0d\u591f\u7406\u60f3\uff0c\u5ffd\u7565\u6210\u672c\uff0c\u4e2a\u4eba\u8ba4\u4e3a\u53e3\u670d\u4e00\u5929\u4e00\u6b21\u4e5f\u4e0d\u89c1\u5f97\u6bd4\u6ce8\u5c04\u4e00\u5468\u4e00\u6b21\u597d\u5230\u54ea\u91cc\u3002<\/span><\/p>\n


<\/span><\/p>\n

\"\u53e3\u670d\u7d22\u9a6c\u9c81\u80bdIII\u671f\u4e34\u5e8a\u6a2a\u626bSGLT-2\/DPP-4\u2014\u2014\u53e3\u670dGLP-1\u964d\u7cd6\u4e0d\u518d\u662f\u68a6\"<\/p>\n

\u6ce8\u5c04\u7528\u7d22\u9a6c\u9c81\u80bd\u5168\u7403\u9500\u91cf<\/span><\/p>\n


<\/span><\/p>\n

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<\/p>\n

\n

1<\/strong><\/span>GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\u5e02\u573a\u60c5\u51b5<\/strong><\/p>\n<\/section>\n


<\/p>\n

\u53c2\u7167IMS\u6570\u636e\uff0cGLP-1\u53d7\u4f53\u6fc0\u52a8\u52422016\u5e74\u5168\u7403\u5e02\u573a\u9500\u552e\u989d\u8fbe69.22\u4ebf\u7f8e\u5143<\/strong>\uff0c \u5360\u636e\u7cd6\u5c3f\u75c5\u7528\u836f\u6574\u4f53\u5e02\u573a\u8fd110%\u7684\u4efd\u989d\uff1b2012-2016\u590d\u5408\u589e\u957f\u7387\u8fbe29.78%<\/strong>\uff0c\u8fdc\u9ad8\u4e8e\u7cd6\u5c3f\u75c5\u7528\u836f\u5e02\u573a14.67%\u7684\u6574\u4f53\u589e\u901f\u3002\u5176\u4e2d\uff0c\u4e00\u5468\u4e00\u6b21\u7684\u957f\u6548GLP-1\u5236\u5242\u51ed\u501f\u5176\u66f4\u4f18\u7684\u4e34\u5e8a\u6548\u679c\u4e0e\u60a3\u8005\u4f9d\u4ece\u6027\uff0c\u5728\u6574\u4e2aGLP-1\u6fc0\u52a8\u5242\u7684\u5e02\u573a\u4efd\u989d\u5360\u6bd4\u75312011\u5e74\u768431%\u63d0\u5347\u52302016\u5e74\u768442%\u3002 2010\u5e74\u7edf\u8ba1\u6570\u636e\u663e\u793a\uff0c\u6211\u56fd\u67091.14\u4ebf\u7cd6\u5c3f\u75c5\u60a3\u8005\uff0c\u53c2\u7167IMS\u6570\u636e\uff0c2016\u5e74\u4e2d\u56fd\u7cd6\u5c3f\u75c5\u7528\u836f\u9500\u552e\u989d\u8fbe216\u4ebf\u4eba\u6c11\u5e01\uff0c\u5e02\u573a\u5e9e\u5927\u3002<\/span>\u66f4\u591a\u7cd6\u5c3f\u75c5\u6570\u636e\u53ef\u4ee5\u53c2\u8003IDF2017\u3002<\/span><\/span><\/p>\n


<\/p>\n

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<\/p>\n

\n

2<\/strong><\/span>\u56fd\u5185GLP-1\u7ade\u4e89\u6fc0\u70c8<\/strong><\/p>\n<\/section>\n


<\/p>\n

\"\u53e3\u670d\u7d22\u9a6c\u9c81\u80bdIII\u671f\u4e34\u5e8a\u6a2a\u626bSGLT-2\/DPP-4\u2014\u2014\u53e3\u670dGLP-1\u964d\u7cd6\u4e0d\u518d\u662f\u68a6\"<\/p>\n


<\/p>\n

1\u3001\u805a\u4e59\u4e8c\u9187\u6d1b\u585e\u90a3\u80bd\u6ce8\u5c04\u6db2<\/strong><\/span><\/p>\n


<\/p>\n

\u805a\u4e59\u4e8c\u9187\u6d1b\u585e\u90a3\u80bd\u6ce8\u5c04\u6db2\u662f\u8c6a\u68ee\u836f\u4e1a\u5f00\u53d1\u7684\u4e00\u6b3e\u957f\u6548GLP-1\u53d7\u4f53\u6fc0\u52a8\u5242\uff0c\u4e00\u5468\u4e00\u6b21\u3002\u4ee3\u53f7\uff1aPEX-168\uff0c\u662f\u5728Exenatide\u7684\u57fa\u7840\u4e0a\u8fdb\u884c\u6c28\u57fa\u9178\u7684\u6539\u9020\u548c\u7ecf\u805a\u4e59\u4e8c\u9187\uff08PEG\uff09\u5316\u4fee\u9970\u800c\u6210\u7684\u964d\u7cd6\u836f\u7269\u3002\u4e8e2017\u5e7412\u6708\u5411CFDA\u9012\u4ea4\u4e86\u4e0a\u5e02\u7533\u8bf7\u3002<\/span><\/p>\n

    \n
  • \n

    \u5916\u90e8\u8d44\u52a9\u8d44\u52a9\u90e8\u95e8\uff1a\u91cd\u5927\u65b0\u836f\u521b\u5236\u91cd\u5927\u4e13\u9879\u5b9e\u65bd\u7ba1\u7406\u529e\u516c\u5ba4<\/span><\/p>\n<\/li>\n

  • \n

    \u9879\u76ee\u540d\u79f0\uff1a\u56fd\u5bb61.1\u7c7b\u957f\u6548\u964d\u7cd6\u65b0\u836fPEX168\u4e34\u5e8a\u7814\u7a76\u3002<\/span><\/p>\n<\/li>\n<\/ul>\n


    <\/p>\n

    PEX-168\u9879\u76ee\u57282016\u5e749\u6708\u6b63\u5f0f\u51b3\u5b9a\u8fdb\u884c\u5168\u9762\u7684\u81ea\u67e5\u548c\u6574\u6539\u3002\u8be5\u9879\u76ee\u8d44\u6599\u6570\u636e\u91cf\u5927\uff0c\u5728\u65f6\u95f4\u7d27\u5f20\u7684\u60c5\u51b5\u4e0b\uff0c\u6052\u745e\u4e34\u5e8a\u56e2\u961f<\/strong>\u5728\u4fdd\u8bc1\u8d28\u91cf\u7684\u524d\u63d0\u4e0b\uff0c\u7ecf\u8fc7\u4e00\u5e74\u591a\u7684\u201c\u594b\u6218\u201d\uff0c\u57282017\u5e7410\u6708\u5b8c\u6210NDA\u7acb\u9879\u7533\u62a5\u3002<\/span><\/p>\n


    <\/p>\n

    2\u3001\u8bfa\u5229\u7cd6\u80bd\u6ce8\u5c04\u6db2(HS20004)<\/span><\/span><\/strong><\/span><\/p>\n


    <\/span><\/strong><\/span><\/p>\n

    \u8c6a\u68ee\u836f\u4e1a\u8fd8\u6709\u53e6\u4e00\u6b3e\u8bfa\u5229\u7cd6\u80bd\u6ce8\u5c04\u6db2\uff08HS20004\uff09\u5728\u5f00\u53d1\u4e2d\uff0c\u76f8\u5173\u4e13\u5229\uff1aGLP-1\u7c7b\u4f3c\u7269\u7684\u884d\u751f\u7269\u6216\u5176\u53ef\u836f\u7528\u76d0\u548c\u7528\u9014\u3002\u6bcf\u65e5\u4e00\u6b21\uff0c\u5728\u5229\u62c9\u9c81\u80bd\u57fa\u7840\u4e0a\u6539\u8fdb\u3002<\/span><\/p>\n


    <\/p>\n

    \"\u53e3\u670d\u7d22\u9a6c\u9c81\u80bdIII\u671f\u4e34\u5e8a\u6a2a\u626bSGLT-2\/DPP-4\u2014\u2014\u53e3\u670dGLP-1\u964d\u7cd6\u4e0d\u518d\u662f\u68a6\"<\/p>\n


    <\/p>\n

    3\u3001<\/strong>\u82cf\u5e15\u9c81\u80bd<\/strong><\/span><\/p>\n


    <\/p>\n

    \u6606\u836f\u96c6\u56e2\u63a7\u80a1\u7684\u94f6\u8bfa\u533b\u836f\u5f00\u53d1\u7684\u4e00\u79cd\u7528\u57fa\u56e0\u5de5\u7a0b\u91cd\u7ec4\u86cb\u767d\u6280\u672f\u5236\u4f5c\u751f\u4ea7\u7684\u521b\u65b0\u751f\u7269\u836f\uff0c\u662fGLP-1\u53d7\u4f53\u7684\u6fc0\u52a8\u5242\uff0c\u67e5\u8be2\u4e13\u5229\uff0c\u672c\u54c1\u4e3a\u957f\u6548GLP-1\u878d\u5408\u86cb\u767d\u3002 \u82cf\u5e15\u9c81\u80bd\u4e8e2017\u5e7411\u670822\u65e5\u5411CFDA\u63d0\u4ea4\u4e86\u4e34\u5e8a\u8bd5\u9a8c\uff08IND\uff09\u7533\u8bf7\uff0c\u5e76\u5df2\u83b7\u5f97\u53d7\u7406\u3002 <\/span><\/p>\n


    <\/span><\/p>\n

    \u622a\u81f3 2017\u5e74 11 \u6708\uff0c\u94f6\u8bfa\u533b\u836f\u5bf9\u8be5\u65b0\u836f\u5df2\u6295\u5165\u7814\u53d1\u8d39\u7528\u7ea65,700\u4e07\u5143\u3002\u4ea7\u54c1\u672a\u6765\u5546\u54c1\u540d\u5b9a\u4e3a\u8fbe\u5fc5\u521a\uff08Diabegone\uff09\uff0c\u5f88\u6709\u5bd3\u610f\u3002<\/span><\/p>\n


    <\/p>\n

    4\u3001Exendin-4<\/strong>\u878d\u5408\u86cb\u767d\uff0cJY09<\/strong><\/span><\/p>\n


    <\/p>\n

      \n
    • \n

      \u4f01\u4e1a\uff1a\u5317\u4eac\u4e1c\u65b9\u767e\u6cf0\u751f\u7269\/\u5317\u4eac\u7cbe\u76ca\u6cf0\u7fd4<\/span><\/p>\n<\/li>\n

    • \n

      \u8d44\u52a9\u90e8\u95e8\uff1a\u4e2d\u534e\u4eba\u6c11\u5171\u548c\u56fd\u79d1\u5b66\u6280\u672f\u90e8<\/span><\/p>\n<\/li>\n

    • \n

      \u9879\u76ee\u540d\u79f0\uff1a\u201c\u91cd\u5927\u65b0\u836f\u521b\u5236\u201d\u79d1\u6280\u91cd\u5927\u4e13\u9879<\/span><\/p>\n<\/li>\n

    • \n

      \u76f8\u5173\u4e13\u5229\uff1a\u4e00\u79cdExendin-4\u53ca\u5176\u7c7b\u4f3c\u7269\u878d\u5408\u86cb\u767d\uff0cCN101891823B<\/span><\/p>\n<\/li>\n<\/ul>\n

      \u8bc4\u4ef7JY09\u5355\u6b21\u6ef4\u5b9a\u7ed9\u836f\u5728\u5065\u5eb7\u5fd7\u613f\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548cPK\/PD\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u2160\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u2161\u578b\u7cd6\u5c3f\u75c5\uff0c\u6b63\u5728\u5f00\u5c55\u4e2d\u3002<\/span><\/p>\n


      <\/p>\n

      5\u3001<\/strong>\u91cd\u7ec4\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd-1\u53d7\u4f53\u6fc0\u52a8\u5242\u6ce8\u5c04\u6db2<\/strong><\/span><\/p>\n


      <\/p>\n

      \u672c\u54c1\u6765\u81ea\u77f3\u836f\u4e2d\u5947\u3002\u91cd\u7ec4\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd-1\u53d7\u4f53\u6fc0\u52a8\u5242\u6ce8\u5c04\u6db2\u4e0e\u51bb\u5e72\u91cd\u7ec4\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd-1\u53d7\u4f53\u6fc0\u52a8\u5242\u4eba\u4f53\u836f\u4ee3\u52a8\u529b\u5b66\u5bf9\u6bd4\u4e34\u5e8a\u8bd5\u9a8c\uff08CTR20160901\uff09I\u671f\u4e34\u5e8a\u5df2\u57282017\u5e741\u6708\u7ed3\u675f\u3002\u8be5\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4e3b\u8981\u76ee\u7684\u4e3a\uff1a\u6bd4\u8f83\u7537\u6027\u5065\u5eb7\u6210\u5e74\u53d7\u8bd5\u8005\u5355\u6b21\u76ae\u4e0b\u6ce8\u5c04\u76f8\u540c\u5242\u91cfrE-4\u6ce8\u5c04\u6db2\u548c\u51bb\u5e72rE-4\u540e\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u53c2\u6570\uff0c\u5224\u65ad\u77f3\u836f\u96c6\u56e2\u4e2d\u5947\u5236\u836f\u6280\u672f\uff08\u77f3\u5bb6\u5e84\uff09\u6709\u9650\u516c\u53f8\u7814\u53d1\u7684\u4e24\u79cd\u5236\u5242\u662f\u5426\u751f\u7269\u7b49\u6548\u3002<\/span><\/p>\n


      <\/p>\n

      \u76ee\u524d\u6b63\u5728\u5f00\u5c55\u91cd\u7ec4\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd-1\u53d7\u4f53\u6fc0\u52a8\u5242\u6ce8\u5c04\u6db2\u6cbb\u7597\u4e2d\u56fd2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u591a\u4e2d\u5fc3\u3001\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u3002\u7528\u4e8e\u6539\u55842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u8840\u7cd6\u63a7\u5236\uff0c\u9002\u7528\u4e8e\u5355\u7528\u4e8c\u7532\u53cc\u80cd\u3001\u78fa\u9170\u8132\u7c7b\uff0c\u4ee5\u53ca\u4e8c\u7532\u53cc\u80cd\u5408\u7528\u78fa\u8132\u7c7b\uff0c\u8840\u7cd6\u4ecd\u63a7\u5236\u4e0d\u4f73\u7684\u60a3\u8005\u3002<\/span><\/p>\n


      <\/span><\/p>\n

      \u4e0a\u8ff0\u8bd5\u9a8c\u7684\u7ec8\u70b9\u6307\u6807\u4e3a\uff1a<\/span><\/p>\n


      <\/p>\n

      \"\u53e3\u670d\u7d22\u9a6c\u9c81\u80bdIII\u671f\u4e34\u5e8a\u6a2a\u626bSGLT-2\/DPP-4\u2014\u2014\u53e3\u670dGLP-1\u964d\u7cd6\u4e0d\u518d\u662f\u68a6\"<\/p>\n


      <\/p>\n

      6\u3001CJC-1134-PC<\/strong><\/span><\/p>\n


      <\/p>\n

      \u672c\u54c1\u6765\u81ea\u5e38\u5c71\u751f\u5316\/ \u5e38\u5c71\u51ef\u6377\u5065\u751f\u7269\u3002CJC-1134-PC \u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167II\u671f\u4e34\u5e8a\u7814\u7a76\u57282\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u6709\u6548\u6027\u53ca\u836f\u4ee3\u52a8\u529b\u5b66\u6b63\u5728\u62db\u52df\u4e2d\u3002<\/span><\/p>\n


      <\/p>\n

      \u4e3b\u8981\u76ee\u7684\uff1a<\/span><\/strong>\u8bc4\u4ef7\u5728\u4e8c\u7532\u53cc\u80cd\u5355\u836f\u6cbb\u7597\u540e\u8840\u7cd6\u63a7\u5236\u4e0d\u4f73\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4e2dCJC-1134-PC\u6ce8\u5c04\u6db2\u6bcf\u5468\u7ed9\u836f1\u6b21\u3001\u8fde\u7eed16\u5468\u7684\u5b89\u5168\u6027\/\u8010\u53d7\u6027\u4e0e\u6709\u6548\u6027\u3002<\/span><\/span><\/p>\n


      <\/p>\n

      \"\u53e3\u670d\u7d22\u9a6c\u9c81\u80bdIII\u671f\u4e34\u5e8a\u6a2a\u626bSGLT-2\/DPP-4\u2014\u2014\u53e3\u670dGLP-1\u964d\u7cd6\u4e0d\u518d\u662f\u68a6\"<\/p>\n


      <\/p>\n

      \u65e9\u57282012\u5e7411\u6708\u5e38\u5c71\u836f\u4e1a\u4e0eConjuChem LLC\u4e8e\u7b7e\u7f72\u5408\u4f5c\u534f\u8bae\uff0c\u53cc\u65b9\u5171\u540c\u6210\u7acb\u4e2d\u5916\u5408\u8d44\u516c\u53f8\u2014\u2014\u5e38\u5c71\u51ef\u6377\u5065\u751f\u7269\u6280\u672f\u836f\u7269\u7814\u53d1\u6709\u9650\u516c\u53f8\uff0c\u5c06ConjuChem LLC\u62e5\u6709\u7684\u7528\u91cd\u7ec4\u4eba\u8840\u767d\u86cb\u767d\u4f5c\u4e3a\u836f\u7269\u8f7d\u4f53\u7684\u836f\u7269\u7ed3\u5408\u5076\u5408\u7269\uff08DAC\uff09\u6280\u672f\u5e73\u53f0\uff0c\u53ca\u4ee5\u8be5\u6280\u672f\u5f00\u53d1\u7684\u5728\u7814\u4ea7\u54c1\u957f\u6548\u6cbb\u7597\u7cd6\u5c3f\u75c5\u836f\u7269CJC-1134-PC\uff08PC-DAC\uff1aExendin-4\uff09\u548c\u80f0\u5c9b\u7d20\u4fee\u9970\u7269\u5728\u7814\u4ea7\u54c1\u7684\u6240\u6709\u6743\u8f6c\u79fb\u5230\u4e2d\u56fd\u53ca\u4e9a\u592a\u5730\u533a\uff0c\u4e0e\u5e38\u5c71\u4e45\u5eb7\u7ec4\u5efa\u5408\u8d44\u516c\u53f8\u4ee5\u5b8c\u6210\u65b0\u836f\u7684\u7814\u53d1\u3002CJC-1134-PC\u4e3b\u8981\u662f\u5c06\u6bcd\u4f53\u5316\u5408\u7269\u827e\u585e\u90a3\u80bd\u8fdb\u884c\u4fee\u9970\uff0c\u7136\u540e\u518d\u4e0e\u91cd\u7ec4\u4eba\u8840\u767d\u86cb\u767d\uff08rHA\uff09\u7ed3\u5408\u3002<\/span><\/p>\n


      <\/p>\n

      \"\u53e3\u670d\u7d22\u9a6c\u9c81\u80bdIII\u671f\u4e34\u5e8a\u6a2a\u626bSGLT-2\/DPP-4\u2014\u2014\u53e3\u670dGLP-1\u964d\u7cd6\u4e0d\u518d\u662f\u68a6\"<\/p>\n


      <\/p>\n

      7\u3001PB-119<\/strong>\u6ce8\u5c04\u6db2\uff08\u805a\u4e59\u4e8c\u9187\u5316\u827e\u585e\u90a3\u80bd\u6ce8\u5c04\u6db2\uff09<\/strong><\/span><\/p>\n


      <\/p>\n

      \u672c\u54c1\u6765\u81ea\u6d3e\u683c\u751f\u7269\u533b\u836f\u3002\u56fd\u5185I\u671f\u4e34\u5e8a\u57282016\u5e7411\u67081\u65e5\u7ed3\u675f\uff0c\u76ee\u524d\u6ca1\u6709\u770b\u5230II\u671f\u4e34\u5e8a\u767b\u8bb0\u30022017\u5e747\u6708PegBio\u5b8c\u62102000\u4e07\u7f8e\u5143E\u8f6e\u878d\u8d44\uff0c\u7531\u5929\u58eb\u529b\u9886\u6295\u3002\u5176\u6b64\u524d\u8868\u793a\u964d\u7cd6\u6c34\u5e73\u4f18\u4e8e\u56fd\u5185\u9996\u4e2a\u4e0a\u5e02\u7684\u77ed\u6548GLP-1\u836f\u7269\u767e\u6ccc\u8fbe\u3002<\/span><\/p>\n


      <\/p>\n

      PB-119\u83b7\u5f97\u91cd\u5927\u65b0\u836f\u521b\u5236\u79d1\u6280\u91cd\u5927\u4e13\u9879\u201c\u5341\u4e09\u4e94\u201d\u7b2c\u4e00\u6279\u8bfe\u9898\u9879\u76ee\u7acb\u9879\uff0c\u5f97\u5230\u56fd\u5bb6\u4e13\u9879\u8d44\u91d1\u5171\u8ba11500\u591a\u4e07\u5143\u7684\u652f\u6301\u3002<\/span><\/p>\n


      <\/p>\n

      8\u3001<\/strong>\u8d1d\u90a3\u9c81\u80bd\uff0c\u91cd\u7ec4\u4eba\u80f0\u9ad8\u8840\u7cd6\u7d20\u7c7b\u591a\u80bd-1\uff087-36\uff09\u6ce8\u5c04\u6db2<\/strong><\/span><\/p>\n


      <\/p>\n

      \u672c\u54c1\u6765\u81ea\u4ec1\u4f1a\u751f\u7269\u30022017\u5e742\u6708\uff0c\u516c\u53f8\u8d1d\u90a3\u9c81\u80bd\u6ce8\u5c04\u6db2\u5b9e\u73b0\u7b2c\u4e00\u7b14\u9500\u552e\u3002\u4e00\u5929\u4e09\u9488\uff0c2017\u4e0a\u534a\u5e74\u9500\u552e656\u4e07\u5143\uff0c\u9884\u8ba1\u5168\u5e74\u8fc7\u5343\u4e07\uff01<\/span><\/p>\n


      <\/p>\n

      \"\u53e3\u670d\u7d22\u9a6c\u9c81\u80bdIII\u671f\u4e34\u5e8a\u6a2a\u626bSGLT-2\/DPP-4\u2014\u2014\u53e3\u670dGLP-1\u964d\u7cd6\u4e0d\u518d\u662f\u68a6\"<\/p>\n


      <\/p>\n

      CDE\u300a2016\u5e74\u5ea6\u836f\u54c1\u5ba1\u8bc4\u62a5\u544a\u300b\u4e2d\u8fd9\u4e48\u63cf\u8ff0\uff1a\u8d1d\u90a3\u9c81\u80bd\u6ce8\u5c04\u6db2\u4e3a\u6211\u56fd\u81ea\u4e3b\u7814\u53d1\u7684\u9996\u4e2a\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd-1\uff08GLP-1\uff09\u7c7b\u4f3c\u7269\uff0c\u5176\u6c28\u57fa\u9178\u5e8f\u5217\u4e0e\u4eba\u4f53\u5185GLP-1\u76f8\u540c\uff0c\u5177\u6709\u8461\u8404\u7cd6\u6d53\u5ea6\u4f9d\u8d56\u7684\u4fc3\u80f0\u5c9b\u7d20\u5206\u6ccc\u4f5c\u7528\uff0c\u5e76\u4e14\u8bf1\u5bfc\u7ec6\u80de\u5206\u5316\uff0c\u6291\u5236\u80f0\u9ad8\u8840\u7cd6\u7d20\u91ca\u653e\u3001\u80c3\u6392\u7a7a\u548c\u6444\u98df\u51b2\u52a8\uff0c\u63d0\u9ad8\u5bf9\u80f0\u5c9b\u7d20\u53d7\u4f53\u7684\u654f\u611f\u6027\u3002\u8be5\u836f\u54c1\u53ef\u663e\u8457\u6539\u55842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u7cd6\u63a7\u5236\uff0c\u63d0\u9ad8\u7cd6\u5316\u8840\u7ea2\u86cb\u767d\u7684\u8fbe\u6807\u7387\uff0c\u5c06\u6ee1\u8db3\u6211\u56fd2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u5bf9\u6b64\u7c7b\u836f\u54c1\u7684\u53ef\u53ca\u6027\u3002<\/span><\/p>\n


      <\/p>\n

      9\u3001<\/strong>\u805a\u4e59\u4e8c\u9187\u5316\u4fc3\u80f0\u5c9b\u7d20\u5206\u6ccc\u80bd\u7c7b\u4f3c\u7269\u6ce8\u5c04\u6db2<\/strong><\/span><\/p>\n


      <\/p>\n

      \u672c\u54c1\u6765\u81ea\u91cd\u5e86\u5bcc\u8fdb\u751f\u7269\uff08\u4e3a\u9c81\u5357\u5236\u836f\uff0c\u5c71\u4e1c\u65b0\u65f6\u4ee3\u63a7\u80a1\u5b50\u516c\u53f8\uff09\u3002\u6d3e\u683c\u90a3\u80bd PEGEXEDIME\u3002\u76f8\u5173\u4e13\u5229\uff1a\u4fc3\u80f0\u5c9b\u7d20\u5206\u6ccc\u80bd\u7c7b\u4f3c\u7269\u540c\u6e90\u4e8c\u805a\u4f53\u53ca\u5176\u7528\u9014\uff0cCN101993485B\u3002\u76ee\u524d\u672a\u67e5\u8be2\u5230\u4e34\u5e8a\u5f00\u5c55\uff0c2016\u5e74\u83b7\u5f97\u7684\u4e34\u5e8a\u6279\u4ef6\u3002<\/span><\/p>\n


      <\/p>\n

      \u6b64\u5916\uff0c\u516c\u53f8\u5f00\u53d1\u7684\u7518\u7cbe\u80f0\u5c9b\u7d20\u6ce8\u5c04\u6db2\u6b63\u5728\u4e09\u671f\u4e34\u5e8a\u4e2d\u3002<\/span><\/p>\n


      <\/p>\n

      10\u3001<\/strong>\u827e\u585e\u90a3\u80bd\u80a0\u6eb6\u7247<\/strong><\/span><\/p>\n


      <\/p>\n

      \u672c\u54c1\u6765\u81ea\u4e0a\u6d77\u84dd\u5fc3\u533b\u836f\u79d1\u6280\uff0c\u76ee\u524d\u662f\u5b89\u535a\u751f\u7269\uff08Ambrx\uff09\u5b50\u516c\u53f8\u3002\u57282016\u5e749\u6708\u62ff\u5230\u4e34\u5e8a\u6279\u4ef6\uff0c\u540c\u6837\u8fd8\u672a\u767b\u8bb0\u4e34\u5e8a\u3002<\/span><\/p>\n


      <\/p>\n

      \u53e3\u670dGLP-1\u7c7b\u4f3c\u7269\uff0c\u76f8\u5173\u4e13\u5229\uff1a\u4e00\u79cd\u7ed9\u836f\u7ec4\u5408\u7269\u53ca\u5176\u5236\u5907\u548c\u4f7f\u7528\u65b9\u6cd5\uff0cCN102100912B\u7b49\u3002\u672c\u53d1\u660e\u63d0\u4f9b\u4e86\u4e00\u79cd\u7528\u4e8e\u7684\u7ed9\u836f\u7ec4\u5408\u7269\u53ca\u5176\u5236\u5907\u548c\u4f7f\u7528\u65b9\u6cd5\u3002\u7ed9\u836f\u7ec4\u5408\u7269\u5305\u62ec\u8f7d\u6709\u6709\u6548\u5242\u91cf\u6cbb\u7597\u7ec4\u5206\u3001\u5438\u6536\u4fc3\u8fdb\u5242\u3001\u836f\u7528\u8f85\u6599\u548c\u542b\u6709\u751f\u7269\u9ecf\u9644\u805a\u5408\u7269\u7684\u751f\u7269\u9ecf\u9644\u5c42\u7684\u56fa\u4f53\u5236\u5242\uff0c\u8fd8\u5305\u62ec\u53ef\u9009\u7684\u9632\u6e17\u900f\u6216\u534a\u6e17\u900f\u5305\u8863\u5c42\uff0c\u4ee5\u4f7f\u5236\u5242\u4e2d\u7684\u6cbb\u7597\u7ec4\u5206\u548c\u5438\u6536\u4fc3\u8fdb\u5242\u5177\u6709\u5355\u5411\u91ca\u653e\u80fd\u529b\u3002\u672c\u53d1\u660e\u7684\u7ed9\u836f\u7ec4\u5408\u7269\u80fd\u4fc3\u8fdb\u96be\u5438\u6536\u836f\u7269\u7684\u5438\u6536\uff0c\u63d0\u9ad8\u751f\u7269\u5229\u7528\u7387\uff0c\u8c03\u8282\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u5f81\uff0c\u63d0\u9ad8\u836f\u7269\u5438\u6536\u6548\u7387\uff0c\u800c\u4e14\u5236\u5242\u4ef7\u683c\u4f4e\u5ec9\uff0c\u76f8\u5bf9\u5bb9\u6613\u751f\u4ea7\u3002<\/span><\/p>\n


      <\/p>\n

      11\u3001<\/strong>\u7279\u6b8a\u5217\u5165\uff0c\u91cd\u7ec4\u6297\u4ebaGLP-1<\/strong>\u53d7\u4f53\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\u6ce8\u5c04\u6db2<\/strong>– Glutazumab<\/strong>\uff08\u683c\u9c81\u5854\u682a\u5355\u6297\uff09<\/strong><\/span><\/p>\n


      <\/p>\n

      \u6765\u81ea\u676d\u5dde\u9e3f\u8fd0\u534e\u5b81\u30022016\u5e744\u6708\uff0c\u9e3f\u8fd0\u534e\u5b81\u201c\u91cd\u7ec4\u6297\u4ebaGLP-1\u53d7\u4f53\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\u6ce8\u5c04\u6db2\u201d\uff08\u4ee3\u53f7\uff1aGMA102\uff09\u5728\u6fb3\u5927\u5229\u4e9a\u542f\u52a8\u76ee\u6807\u9002\u5e94\u75c7\u4e3a2\u578b\u7cd6\u5c3f\u75c5\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u5176\u4f5c\u7528\u673a\u7406\u4e3b\u8981\u901a\u8fc7\u548c\u4eba\u4f53\u7ec6\u80de\u8868\u9762\u7684GLP-1R\u76f8\u7ed3\u5408\u6765\u6fc0\u6d3b\u7ec6\u80de\u5185\u8be5\u53d7\u4f53\u7684\u4e0b\u6e38\u4fe1\u53f7\u901a\u8def\uff0c\u8c03\u8282\u548c\u5f71\u54cd\u4e0d\u540c\u810f\u5668\u4e2d\u4e0e\u4eba\u4f53\u7cd6\u4ee3\u8c22\u76f8\u5173\u7684\u5404\u9879\u529f\u80fd\uff0c\u4fc3\u8fdb\u4eba\u4f53\u7ec6\u80de\u7cd6\u4ee3\u8c22\uff0c\u964d\u4f4e\u8840\u7cd6\u3002<\/span><\/p>\n


      <\/p>\n

      \u76ee\u524d\u6b63\u5728\u6fb3\u6d32\u5f00\u5c55\u4e8c\u671f\u4e34\u5e8a\u3002\u5176\u4ed6\u8be6\u89c1IDF2017\uff0c\u9e3f\u8fd0\u534e\u5b81poster\uff1aA phase I study to investigate the safety, tolerability and pharmacokinetics of a biased GLP-1R antibody Glutazumab\u3002<\/span><\/p>\n


      <\/p>\n

      12\u3001<\/strong>\u6ce8\u5c04\u7528\u91cd\u7ec4\u827e\u585e\u90a3\u80bd-<\/strong>\u4eba\u8840\u6e05\u767d\u86cb\u767d\u878d\u5408\u86cb\u767d(<\/strong>\u9175\u6bcd\u83cc)<\/strong><\/span><\/p>\n


      <\/p>\n

      \u672c\u54c1\u4e3a1\u7c7b\u751f\u7269\u836f\uff0c\u6765\u81ea\u6d59\u6c5f\u534e\u9633\u836f\u4e1a\uff0c\u5c062\u4e2a\u4e32\u8054\u7684\u827e\u585e\u90a3\u80bd\u548c\u767d\u86cb\u767d\u5728\u9175\u6bcd\u83cc\u4e2d\u5171\u540c\u8868\u8fbe\u4ece\u800c\u5f97\u5230\u7684\u65b0\u578b\u878d\u5408\u86cb\u767d\uff08E2HSA\uff09\u30022016\u5e7411\u6708\u83b7\u6279\u4e34\u5e8a\u3002<\/span><\/p>\n

      \"\u53e3\u670d\u7d22\u9a6c\u9c81\u80bdIII\u671f\u4e34\u5e8a\u6a2a\u626bSGLT-2\/DPP-4\u2014\u2014\u53e3\u670dGLP-1\u964d\u7cd6\u4e0d\u518d\u662f\u68a6\"<\/p>\n

      \u4f9d\u636e\u516c\u53f8\u5bf9\u751f\u4ea7\u6210\u672c\u3001\u7814\u53d1\u6210\u672c\u7684\u6d4b\u7b97\uff0c\u6bcf\u4efdE2HSA\u5236\u5242\u6682\u5b9a\u672a\u6765\u51fa\u5382\u4ef7150\u5143\uff0c\u6bdb\u5229\u7387\u8fbe70%\uff1b\u5176\u4e2d\u6210\u4ea7\u6210\u672c\u4e3b\u8981\u5305\u62ec\u8017\u6750\uff08\u542b\u57f9\u517b\u57fa\u3001\u5305\u88c5\u76d2\u3001\u9488\u7b52\u7b49\uff09\u3001\u4eba\u5de5\u5de5\u8d44\u3001\u6298\u65e7\u3001\u6c34\u7535\u6c7d\u8d39\u7528\u3001\u5e7f\u544a\u8d39\u7528\u7b49\u4e94\u65b9\u9762\uff0c\u8017\u6750\u7684\u5355\u4f4d\u6210\u672c\u7ea6\u6bcf\u4efd\u5236\u52424.6\u5143\u3002<\/span><\/p>\n


      <\/p>\n

      13\u3001BPI-3016\u6ce8\u5c04\u6db2<\/span><\/strong><\/span><\/p>\n


      <\/span><\/p>\n

      \u8d1d\u8fbe\u836f\u4e1a\u7684\u65b0\u578b\u964d\u7cd6\u836fBPI-3016\u6ce8\u5c04\u6db2\u5c5e\u4e8eGLP-1\u957f\u6548\u7c7b\u4f3c\u7269\uff0c2017\u5e743\u6708\u83b7\u6279\u4e34\u5e8a\u3002<\/span><\/p>\n


      <\/p>\n

      14\u3001\u5176\u4ed6\u56fd\u5185\u7533\u62a5\u7684\u54c1\u79cd<\/span><\/strong><\/span><\/p>\n


      <\/span><\/p>\n

      \u5176\u4ed6\u56fd\u5185\u7533\u62a5\u7684\u54c1\u79cd\u9664\u56fd\u5916\u539f\u7814GLP-1\u76f8\u5173\u836f\u7269\u5916\uff0c\u8fd8\u6709\u827e\u585e\u90a3\u80bd\u6ce8\u5c04\u6db2\/\u5fae\u7403\u4eff\u5236\u836f\uff08\u957f\u6625\u9ad8\u65b0-\u957f\u6625\u767e\u76ca\u3001\u5c71\u4e1c\u7eff\u53f6\u3001\u6df1\u5733\u7ff0\u5b87\u3001\u9655\u897f\u9ea6\u79d1\u5965\u7279\u3001\u5c71\u4e1c\u9f50\u9c81\u3001\u6210\u90fd\u5723\u8bfa\u3001\u4e5d\u6e90\u57fa\u56e0\u7b49\uff09\uff1b\u5229\u62c9\u9c81\u80bd\u6ce8\u5c04\u6db2\u4eff\u5236\u836f\uff08\u534e\u4e1c\u533b\u836f-\u4e5d\u6e90\u57fa\u56e0\u3001\u4e1c\u9633\u5149\u3001\u6b63\u5927\u5929\u6674\u3001\u6df1\u5733\u7ff0\u5b87\u3001\u91cd\u5e86\u6d3e\u91d1\uff09\u7b49\u3002<\/span><\/p>\n


      <\/p>\n

      \n

      \u5c0f\u7f16\u603b\u7ed3<\/span><\/strong><\/span><\/p>\n<\/blockquote>\n


      <\/span><\/p>\n

      \u56fd\u5185\u7cd6\u5c3f\u75c5\u5e02\u573a\u7a7a\u95f4\u5de8\u5927\uff0c\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u80f0\u5c9b\u7d20\u4f7f\u7528\u7387\u548cGLP-1\u4f7f\u7528\u7387\u8fdc\u4f4e\u4e8e\u53d1\u8fbe\u56fd\u5bb6\uff0c\u8840\u7cd6\u63a7\u5236\u8fbe\u6807\u7387\u4e5f\u6709\u5f88\u5927\u63d0\u5347\u7a7a\u95f4\u3002\u56fd\u5185\u80f0\u5c9b\u7d20\u9886\u57df\u7ade\u4e89\u5f88\u5feb\u8fdb\u5165\u767d\u70ed\u5316\uff0c\u5404\u5bb6\u836f\u4f01\u52a8\u8f84\u8017\u8d44\u6570\u4ebf\u5143\u3001\u6570\u5341\u4ebf\u5143\u6295\u5165\u8be5\u9886\u57df\u7684\u7ade\u4e89\uff0c\u8003\u8651\u5230\u5168\u7403\u8303\u56f4\u6bcf\u5e7410\u5428\u5de6\u53f3\u80f0\u5c9b\u7d20\u9700\u6c42\uff0c\u76ee\u524d\u56fd\u5185\u7684\u80f0\u5c9b\u7d20\u751f\u4ea7\u80fd\u529b\u5df2\u7ecf\u8fdc\u8d85\u8fd9\u4e2a\u6570\u5b57\u3002\u672a\u6765\u5c06\u4e0d\u53ef\u907f\u514d\u7684\u8fdb\u5165\u4ef7\u683c\u6218\u9636\u6bb5\uff0c\u8003\u8651\u5230\u80f0\u5c9b\u7d20\u4f5c\u4e3a\u6162\u75c5\u7528\u836f\uff0c\u60a3\u8005\u57fa\u6570\u5927\u3001\u7c98\u6027\u5f3a\u3001\u66ff\u4ee3\u6162\uff0c\u8be5\u9886\u57df\u9700\u8981\u957f\u65f6\u95f4\u3001\u5de8\u989d\u7684\u6295\u5165\u671f\uff0c\u6700\u7ec8\u5c06\u6dd8\u6c70\u4e00\u4e9b\u4f9b\u5e94\u5546\u5e76\u4f5c\u8fdb\u4e00\u6b65\u7684\u5408\u5e76\uff0c\u4ee5\u8fdb\u5165\u53d1\u5c55\u7684\u6210\u719f\u671f\u3002\u8003\u8651\u5230\u56fd\u5185\u80f0\u5c9b\u7d20\u751f\u4ea7\u80fd\u529b\u7684\u5e03\u5c40\uff0c\u8fdb\u5165\u56fd\u9645\u5e02\u573a\u5c24\u5176\u662f\u53d1\u8fbe\u56fd\u5bb6\u5e02\u573a\u662f\u5fc5\u7136\u8d8b\u52bf\u3002\u5bf9\u4e8e\u53d1\u8fbe\u56fd\u5bb6\u7684\u77e5\u8bc6\u4ea7\u6743\u73af\u5883\u3001\u5e02\u573a\u51c6\u5165\u3001\u9500\u552e\u63a8\u5e7f\uff0c\u5de8\u5927\u7684\u5e02\u573a\u7a7a\u95f4\u540c\u65f6\u610f\u5473\u7740\u5de8\u5927\u7684\u6311\u6218\u3002<\/span><\/p>\n


      <\/p>\n

      \u58f0\u660e\uff1a\u8f6c\u8f7d\u8bf7\u52a1\u5fc5\u6ce8\u660e\u672c\u6587\u6765\u6e90\u53ca\u4f5c\u8005\u3002<\/strong><\/span><\/p>\n


      <\/p>\n

      \n
      \n
      \n
      \n
      \n
      \n
      \n
      \n
      \n
      \n
      \n
      \n
      <\/section>\n<\/section>\n<\/section>\n<\/section>\n
      \n
      \n
      \n
      <\/section>\n<\/section>\n<\/section>\n<\/section>\n
      \n
      \n
      \n
      <\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
      \n
      \n

      \u5b66\u5982\u9006\u6c34\u884c\u821f\uff0c\u4e0d\u8fdb\u5219\u9000\uff1b<\/span><\/p>\n

      \u5fc3\u4f3c\u5e73\u539f\u8d70\u9a6c\uff0c\u6613\u653e\u96be\u6536\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

      \n
      \n
      \n
      \n
      \n
      <\/section>\n<\/section>\n<\/section>\n<\/section>\n
      \n
      \n
      <\/section>\n<\/section>\n<\/section>\n
      \n
      \n
      \n

      <\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


      <\/p>\n

      \"\u53e3\u670d\u7d22\u9a6c\u9c81\u80bdIII\u671f\u4e34\u5e8a\u6a2a\u626bSGLT-2\/DPP-4\u2014\u2014\u53e3\u670dGLP-1\u964d\u7cd6\u4e0d\u518d\u662f\u68a6\"<\/p>\n


      <\/p>\n


      <\/p>\n

      \n
      \n
      \n
      \n
      \n

      \u884c\u821fDrug<\/span><\/p>\n<\/section>\n

      \n

      \u6bcf\u65e5\u66f4\u65b0 \u6b22\u8fce\u8ba2\u9605+<\/span><\/p>\n

      \n


      <\/p>\n

      \n<\/section>\n


      <\/p>\n

      \u533b\u836f\u5927\u6570\u636e|\u884c\u4e1a\u52a8\u6001|\u653f\u7b56\u89e3\u8bfb<\/span><\/p>\n


      <\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

      \n

      \u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u884c\u821fDrug <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

      \u70b9\u51fb\u4e0a\u65b9\u7684 \u884c\u821fDrug \u25b2 \u6dfb\u52a0\u5173\u6ce8 2018\u5e742\u670822\u65e5\uff0c\u8bfa\u548c\u8bfa\u5fb7\u5ba3\u5e03\u4e86\u53e3\u670d […]<\/p>\n","protected":false},"author":1,"featured_media":7280,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/7279"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=7279"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/7279\/revisions"}],"predecessor-version":[{"id":7296,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/7279\/revisions\/7296"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/7280"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=7279"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=7279"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=7279"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}