{"id":73138,"date":"2018-12-03T01:00:00","date_gmt":"2018-12-07T05:13:05","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/16b342585e\/"},"modified":"2018-12-07T13:13:10","modified_gmt":"2018-12-07T05:13:10","slug":"16b342585e","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/73138\/","title":{"rendered":"ALL Pain, NO Gain&#8212;-\u836f\u7269\u53d1\u73b0\u4e2d\u7684\u201c\u7b5b\u9009\u5e72\u6270\u5316\u5408\u7269\u201d"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"text-align: center;\"><span style=\"color: rgb(51, 51, 51);font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 14px;letter-spacing: 0.544px;text-align: center;text-indent: 28px;background-color: rgb(255, 255, 255);\">\u70b9\u51fb\u4e0a\u65b9\u7684&nbsp;&nbsp;\u25b2&nbsp;\u6dfb\u52a0\u5173\u6ce8<\/span><\/p>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/1-1544159586.jpg\" alt=\"ALL Pain, NO Gain----\u836f\u7269\u53d1\u73b0\u4e2d\u7684\u201c\u7b5b\u9009\u5e72\u6270\u5316\u5408\u7269\u201d\" title=\"ALL Pain, NO Gain----\u836f\u7269\u53d1\u73b0\u4e2d\u7684\u201c\u7b5b\u9009\u5e72\u6270\u5316\u5408\u7269\u201d\"  \/><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;text-indent: 2em;\"><span style=\"font-size: 14px;\">\u5267\u60c5\u6897\u6982\uff1a\u836f\u7269\u53d1\u73b0\u7684\u4e16\u754c\u91cc\uff0c\u81f3\u4eca\u98d8\u8361\u7740\u8fd9\u6837\u4e00\u7fa4\u88ab\u79f0\u4e3a\u201cPAINS\u201d\u7684\u5e7d\u9b42\u3002\u5b83\u4eec\u65f6\u800c\u95ea\u4eae\u51fa\u73b0\uff0c\u65f6\u800c\u9041\u533f\u9690\u5f62\uff0c\u7ed9\u836f\u7269\u53d1\u73b0\u8005\u5e26\u6765\u65e0\u5c3d\u7684\u60b2\u559c\u3002\u5b83\u4eec\u79f0\u5f97\u4e0a\u662f\u5316\u5b66\u7a7a\u95f4\u7684\u201c\u6700\u4f73\u6f14\u5458\u201d\uff0c\u53ea\u53ef\u60dc\uff0c\u5b83\u4eec\u662f\u5367\u5e95&#8230;<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"          style=\"width: 100%;height: auto;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/1-1544159587.jpg\" alt=\"ALL Pain, NO Gain----\u836f\u7269\u53d1\u73b0\u4e2d\u7684\u201c\u7b5b\u9009\u5e72\u6270\u5316\u5408\u7269\u201d\" title=\"ALL Pain, NO Gain----\u836f\u7269\u53d1\u73b0\u4e2d\u7684\u201c\u7b5b\u9009\u5e72\u6270\u5316\u5408\u7269\u201d\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;text-indent: 2em;\"><span style=\"font-size: 14px;\">\u201c\u4f17\u91cc\u5bfb\u4ed6\u5343\u767e\u5ea6\u201d\uff0c\u4e3a\u4e86\u53d1\u73b0\u65b0\u7ed3\u6784\u3001\u65b0\u9776\u6807\u7684\u6291\u5236\u5242\uff0c\u836f\u7269\u7814\u7a76\u8005\u5728\u5316\u5b66\u7a7a\u95f4\u4e2d\u4ee5\u201c\u613f\u6458\u6ee1\u5929\u661f\u201d\u7684\u52b2\u5934\uff0c\u4e00\u6b21\u6b21\u5728\u6570\u4ee5\u767e\u4e07\u8ba1\u7684\u5316\u5408\u7269\u7ed3\u6784\u4e2d\u5bfb\u627e\u5177\u6709\u751f\u7269\u6d3b\u6027\u7684\u836f\u7269\u5148\u5bfc\u5316\u5408\u7269\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;text-indent: 2em;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;text-indent: 2em;\"><span style=\"font-size: 14px;\">\u501f\u52a9\u4e8e\u9ad8\u901a\u91cf\u7b5b\u9009\u7b49\u6280\u672f\uff0c\u836f\u7269\u53d1\u73b0\u8005\u5f80\u5f80\u80fd\u53d1\u73b0\u4e0d\u9519\u7684\u201c\u6d3b\u6027\u201d\u5316\u5408\u7269\u3002\u5178\u578b\u7684\u9ad8\u901a\u91cf\u7b5b\u9009\u9879\u76ee\u901a\u5e38\u7684\u53d1\u73b0\u6982\u7387\u7ea6\u4e3a0.7%\uff0c\u5373\u5728100000\u4e2a\u5316\u5408\u7269\u4e2d\uff0c\u53ef\u4ee5\u53d1\u73b0\u8fd1\u4e03\u767e\u4e2a\u5316\u5408\u7269\u5177\u6709\u4e00\u5b9a\u7684\u6d3b\u6027\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;text-indent: 2em;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;text-indent: 2em;\"><span style=\"font-size: 14px;\">\u4f46\u5f53\u4eba\u4eec\u5174\u81f4\u52c3\u52c3\u5bf9\u5b83\u8fdb\u884c\u8fdb\u4e00\u6b65\u7814\u7a76\u65f6\uff0c\u5f88\u591a\u5316\u5408\u7269\u5c55\u73b0\u51fa\u6765\u7684\u201c\u6d3b\u6027\u201d\u4ec5\u4ec5\u662f\u4e00\u79cd\u865a\u5e7b\u7684\u5047\u9633\u6027\u7ed3&#8212;&#8211;\u5b83\u4eec\u7684\u201c\u6d3b\u6027\u201d\u5e76\u975e\u6e90\u4e8e\u5316\u5408\u7269\u5206\u5b50\u4e0e\u86cb\u767d\u8d28\u4e4b\u95f4\u7279\u5f02\u6027\u7684\u4f5c\u7528\u3002\u771f\u6b63\u7684\u6f5c\u5728\u836f\u7269\u5206\u5b50\u80fd\u591f\u7cbe\u786e\u4f5c\u7528\u4e8e\u7279\u5b9a\u86cb\u767d\u8d28\u7684\u7ed3\u5408\u4f4d\u70b9\uff0c\u4ece\u800c\u6291\u5236\u6216\u6fc0\u6d3b\u86cb\u767d\u8d28\u7684\u529f\u80fd\u3002\u800c\u201c\u5047\u9633\u6027\u5316\u5408\u7269\u201d\u5219\u4f2a\u88c5\u6210\u836f\u7269\u7ed3\u5408\u7684\u6837\u5b50\uff0c\u5728\u5404\u79cd\u7b5b\u9009\u7814\u7a76\u4e2d\u5927\u653e\u70df\u96fe\u5f39\u3002\u8fd9\u4e9b\u5316\u5408\u7269\u5c31\u662fPan Assay INterference compoundS(PAINS)\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;text-indent: 2em;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;text-indent: 2em;\"><span style=\"font-size: 14px;\">\u4ee5\u9976\u4e39\u5b81\uff08Rhodanines\uff09\u7c7b\u5316\u5408\u7269\u4e3a\u4f8b\uff0c\u5df2\u8d85\u8fc7588\u7bc7\u8bba\u6587\u548c\u4e13\u5229\u62a5\u9053\u4e867919\u4e2a\u8be5\u7c7b\u5316\u5408\u7269\u8868\u73b0\u51fa\u751f\u7269\u5b66\u6d3b\u6027\uff0c\u4f46\u65f6\u81f3\u4eca\u65e5\u6ca1\u6709\u4e00\u4e2a\u9976\u4e39\u5b81\u7c7b\u5316\u5408\u7269\u8fdb\u5165\u771f\u6b63\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u836f\u7269\u7814\u7a76\u8005\u7684\u7814\u7a76\u70ed\u60c5\u4e0e\u52aa\u529b\u4e5f\u4ed8\u8bf8\u4e1c\u6d41\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;text-indent: 2em;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;text-indent: 2em;\"><span style=\"font-size: 14px;\">\u968f\u7740\u8fd9\u6837\u201c\u9047\u4eba\u4e0d\u6dd1\u201d\u7684\u6545\u4e8b\u4e00\u6b21\u6b21\u53d1\u751f\uff0c\u6587\u732e\u8bba\u6587\u7684\u4e00\u6b21\u6b21\u53d1\u8868\uff0c\u8fd9\u6837\u4e00\u4e9b\u5316\u5408\u7269\u88ab\u53cd\u590d\u62a5\u9053\u5177\u6709\u591a\u6837\u7684\u201c\u751f\u7269\u5b66\u6d3b\u6027\u201d\uff0c\u8bef\u5bfc\u5176\u4ed6\u7814\u7a76\u8005\u8fdb\u884c\uff0c\u5f88\u591a\u836f\u7269\u53d1\u73b0\u7684\u52aa\u529b\u5c31\u5728\u8fd9\u4e00\u8f6e\u8f6e\u5f92\u52b3\u65e0\u671b\u7684\u201c\u6d77\u5e02\u8703\u697c\u201d\u822c\u7684\u865a\u8c61\u4e2d\u88ab\u4e00\u6b21\u6b21\u8bef\u5bfc\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/5-1544159588.jpg\" alt=\"ALL Pain, NO Gain----\u836f\u7269\u53d1\u73b0\u4e2d\u7684\u201c\u7b5b\u9009\u5e72\u6270\u5316\u5408\u7269\u201d\" title=\"ALL Pain, NO Gain----\u836f\u7269\u53d1\u73b0\u4e2d\u7684\u201c\u7b5b\u9009\u5e72\u6270\u5316\u5408\u7269\u201d\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;text-indent: 2em;\"><span style=\"font-size: 14px;\">\u201cPAINS\u201d\u5316\u5408\u7269\u5305\u62ec\u591a\u79cd\u5316\u5408\u7269\u7ed3\u6784\u7c7b\u578b, \u8868\u73b0\u751f\u7269\u6d3b\u6027\u7684\u4f5c\u7528\u673a\u5236\u4e00\u822c\u4e0e\u5df2\u516c\u8ba4\u7684\u53d7\u4f53\u914d\u4f53\u7ed3\u5408\u673a\u5236\u4e0d\u540c, \u800c\u4e14\u7ed3\u5408\u7684\u6d53\u5ea6\u4e00\u822c\u5728\u5fae\u6469\u5c14\u7ea7\u522b, \u901a\u5e38\u8868\u73b0\u4e3a\u975e\u7ade\u4e89\u6027\u3001\u65e0\u660e\u663e\u6784\u6548\u5173\u7cfb\u53ca\u8f83\u5dee\u7684\u7279\u5f02\u6027\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;text-indent: 2em;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;text-indent: 2em;\"><span style=\"font-size: 14px;\">\u201cPAINS\u201d\u5316\u5408\u7269\u4ea7\u751f\u6240\u8c13\u201c\u751f\u7269\u6d3b\u6027\u201d\u4e3b\u8981\u673a\u5236\u6709: \u76f4\u63a5\u5e72\u6270\u7b5b\u9009\u8fc7\u7a0b\u7684\u68c0\u6d4b\u4fe1\u53f7\u3001\u5316\u5408\u7269\u5206\u5b50\u5f62\u6210\u805a\u5408\u4f53\u4e0e\u9776\u70b9\u7ed3\u5408\u3001\u4ea7\u751f\u5355\u7ebf\u6001\u6c27\u5f62\u6210\u975e\u7279\u5f02\u6027\u53cd\u5e94\u3001\u975e\u7279\u5f02\u6027\u7684\u86cb\u767d\u6b8b\u57fa\u4fee\u9970\u53ca\u8026\u5408\u91d1\u5c5e\u9176\u53d1\u6325\u6d3b\u6027\u6240\u5fc5\u987b\u7684\u91d1\u5c5e\u79bb\u5b50\u3002\u201cPAINS\u201d\u5316\u5408\u7269\u53ef\u80fd\u5305\u542b\u8fd1480\u79cd\u7ed3\u6784, \u4f46\u7ea6\u670916\u79cd\u51fa\u73b0\u9891\u7387\u8f83\u9ad8\u7684\u7c7b\u578b,\u5360\u636e58%\u201cPAINS\u201d<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/10-1544159588.jpg\" alt=\"ALL Pain, NO Gain----\u836f\u7269\u53d1\u73b0\u4e2d\u7684\u201c\u7b5b\u9009\u5e72\u6270\u5316\u5408\u7269\u201d\" title=\"ALL Pain, NO Gain----\u836f\u7269\u53d1\u73b0\u4e2d\u7684\u201c\u7b5b\u9009\u5e72\u6270\u5316\u5408\u7269\u201d\"  \/><\/p>\n<p style=\"text-align: center;line-height: 1.75em;text-indent: 0em;\"><span style=\"font-size: 14px;\">\u4e3b\u8981\u7684\u4ee3\u8868\u6027\u7684\u201cPAINS\u201d\u5316\u5408\u7269\u7ed3\u6784\u7c7b\u578b<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/8-1544159589.jpg\" alt=\"ALL Pain, NO Gain----\u836f\u7269\u53d1\u73b0\u4e2d\u7684\u201c\u7b5b\u9009\u5e72\u6270\u5316\u5408\u7269\u201d\" title=\"ALL Pain, NO Gain----\u836f\u7269\u53d1\u73b0\u4e2d\u7684\u201c\u7b5b\u9009\u5e72\u6270\u5316\u5408\u7269\u201d\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;text-indent: 2em;\"><span style=\"font-size: 14px;\">\u4e0b\u9762\u6765\u770b\u4e00\u4e0b\u4e0a\u56fe\u4e2d\u201cPAINS\u201d\u5316\u5408\u7269\u4e2d\u7684\u60ef\u72af\uff0c\u770b\u770b\u5b83\u4eec\u662f\u5982\u4f55\u5728\u836f\u7269\u53d1\u73b0\u7684\u4e16\u754c\u4e2d\u201c\u4f5c\u5978\u72af\u79d1\u201d\u7684\uff1a<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;text-indent: 2em;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;text-indent: 2em;\"><span style=\"font-size: 14px;\">Toxoflavin\uff08\u6bd2\u9ec4\u7d20\uff09\u7c7b\u5316\u5408\u7269\u4f5c\u4e3a\u6c27\u5316\u8fd8\u539f\u5faa\u73af\u7684\u4fc3\u8fdb\u5242\uff0c\u53ef\u4ee5\u4ea7\u751f\u8fc7\u6c27\u5316\u6c22\u4f7f\u9776\u6807\u86cb\u767d\u6fc0\u6d3b\u6216\u8005\u5931\u6d3b\uff1b\u5f02\u567b\u5511\u916e\u7c7b\u5316\u5408\u7269\u6613\u4e8e\u53d1\u751fN-S\u952e\u65ad\u88c2\uff0c\u53ef\u4ee5\u4f5c\u4e3a\u5171\u4ef7\u4fee\u9970\u5316\u5408\u7269\uff0c\u5171\u4ef7\u975e\u7279\u5f02\u6027\u5730\u4fee\u9970\u9776\u6807\u86cb\u767d\u534a\u80f1\u6c28\u9178\u6b8b\u57fa\uff1bCurcumin\uff08\u59dc\u9ec4\u7d20\uff09\u7c7b\u5316\u5408\u7269\uff0c\u65e2\u662f\u5171\u4ef7\u4fee\u9970\u5316\u5408\u7269\uff0c\u540c\u65f6\u4e5f\u53ef\u4ee5\u5e72\u6270\u7ec6\u80de\u819c\u5730\u7a33\u5b9a\u6027\u5f71\u54cd\u819c\u53d7\u4f53\u7684\u54cd\u5e94\uff1b\u7f9f\u57fa\u82c4\u57fa\u8159\u7c7b\u548c\u9976\u4e39\u5b81\uff08Rhodanines\uff09\u7c7b\u5316\u5408\u7269\uff0c\u65e2\u662f\u5171\u4ef7\u4fee\u9970\u5316\u5408\u7269\uff0c\u540c\u65f6\u4e5f\u53ef\u4ee5\u7edc\u5408\u4e0e\u9776\u6807\u751f\u7269\u6d3b\u6027\u76f8\u5173\u7684\u91d1\u5c5e\u79bb\u5b50\uff1b\u82ef\u915a-\u78fa\u9170\u80fa\u7c7b\u5316\u5408\u7269\u9664\u4e86\u6c27\u5316\u8fd8\u539f\u5faa\u73af\u4fc3\u8fdb\u5242\u3001\u5171\u4ef7\u4fee\u9970\u5242\u7684\u89d2\u8272\uff0c\u5176\u5316\u5b66\u4e0d\u7a33\u5b9a\u6027\u53ef\u4ea7\u751f\u5e72\u6270\u68c0\u6d4b\u578b\u53f7\u7684\u5e72\u6270\u5316\u5408\u7269\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/0-1544159589.jpg\" alt=\"ALL Pain, NO Gain----\u836f\u7269\u53d1\u73b0\u4e2d\u7684\u201c\u7b5b\u9009\u5e72\u6270\u5316\u5408\u7269\u201d\" title=\"ALL Pain, NO Gain----\u836f\u7269\u53d1\u73b0\u4e2d\u7684\u201c\u7b5b\u9009\u5e72\u6270\u5316\u5408\u7269\u201d\"  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;text-indent: 2em;\"><span style=\"font-size: 14px;\">\u70ef\u916e\u7c7b\u548c\u918c\u7c7b\u5316\u5408\u7269\u662f\u5178\u578b\u7684\u5171\u4ef7\u4fee\u9970\u5316\u5408\u7269\uff1b\u800c\u591a\u915a\u7c7b\u5316\u5408\u7269\u53ef\u4f5c\u4e3a\u6c27\u5316\u8fd8\u539f\u5faa\u73af\u4fc3\u8fdb\u5242\u3001\u5171\u4ef7\u4fee\u9970\u5242\u548c\u91d1\u5c5e\u7edc\u5408\u5242\uff0c\u4ea7\u751f\u5047\u9633\u6027\u4fe1\u53f7\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;text-indent: 2em;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;text-indent: 2em;\"><span style=\"font-size: 14px;\">2017\u5e742\u6708\uff0cACS\u65d7\u4e0b8\u79cd\u520a\u7269\u8054\u5408\u53d1\u8868\u9898\u4e3a\u300aThe Ecstasy and Agony of Assay Interference Compounds\u300b\u7684\u7f16\u8f91\u90e8\u8bc4\u8bba\u6587\u7ae0\uff0c\u9762\u5411\u836f\u7269\u7814\u7a76\u4eba\u5458\u7279\u522b\u662f\u5b66\u672f\u754c\u7814\u7a76\u4eba\u5458\u9ad8\u5ea6\u91cd\u89c6\u7b5b\u9009\u5e72\u6270\u5316\u5408\u7269\u5bf9\u836f\u7269\u53d1\u73b0\u7684\u8bef\u5bfc\u548c\u5e72\u6270\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;text-indent: 2em;\"><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/1-1544159590.jpg\" alt=\"ALL Pain, NO Gain----\u836f\u7269\u53d1\u73b0\u4e2d\u7684\u201c\u7b5b\u9009\u5e72\u6270\u5316\u5408\u7269\u201d\" title=\"ALL Pain, NO Gain----\u836f\u7269\u53d1\u73b0\u4e2d\u7684\u201c\u7b5b\u9009\u5e72\u6270\u5316\u5408\u7269\u201d\"  \/><\/p>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;text-indent: 2em;\"><span style=\"font-size: 14px;\">\u201c\u771f\u91d1\u4e0d\u6015\u706b\u70bc\u201d\u3002\u4e00\u65e6\u836f\u7269\u7814\u7a76\u8005\u5bf9\u201cPAINS\u201d\u5316\u5408\u7269\u7ed9\u4e88\u9ad8\u5ea6\u7684\u8b66\u89c9\uff0c\u5229\u7528\u591a\u91cd\u624b\u6bb5\u786e\u8ba4\u5148\u5bfc\u5316\u5408\u7269\u7684\u673a\u5236\uff0c\u5b9a\u80fd\u201cPAINS\u201d\u5316\u5408\u7269\u65e0\u5904\u85cf\u8eab\uff0c\u53d1\u73b0\u771f\u6b63\u6709\u4ef7\u503c\u7684\u201cMrRight\u201d\u836f\u7269\u5206\u5b50\u7528\u4e8e\u836f\u7269\u7684\u7814\u53d1\u3002<\/span><\/p>\n<p style=\"text-align: justify;line-height: 1.75em;text-indent: 2em;\"><span style=\"font-size: 14px;\">&nbsp;<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">\u53c2\u8003\u6587\u732e\uff1a<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">1. Pain ofhigh-throughput screening&#8212;pan assay interference compounds. ActaPharmaceutica Sinica 2015, 50 (8): 925-930.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">2. Chemical conartists foil drug discovery.Nature 2014,513, 481-483.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">3. The Ecstasy andAgony of Assay Interference Compounds. ACS Med. Chem. Lett. 2017,8, 379\u2212382.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">4. \u679c\u58f3\uff1a\u5047\u9633\u6027\u5316\u5408\u7269\uff1a\u836f\u7269\u7814\u53d1\u8005\u7684\u5fc3\u5934\u4e4b\u201c\u75db\u201d. https:\/\/www.guokr.com\/article\/439308\/<\/span><\/p>\n<p><br  \/><\/p>\n<p><br  \/><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;line-height: 25px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u58f0\u660e\uff1a\u8f6c\u8f7d\u8bf7\u52a1\u5fc5\u6ce8\u660e\u672c\u6587\u6765\u6e90\u53ca\u4f5c\u8005\u3002<\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;line-height: 25px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\"   style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;overflow-wrap: break-word !important;\">\n<section style=\"padding: 10px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;width: 536px;text-align: center;font-size: 20px;font-weight: bold;display: -webkit-flex;justify-content: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\"  style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4f5c\u8005\u6587\u7ae0\u63a8\u8350\uff1a<\/span><\/section>\n<\/section>\n<section  style=\"max-width: 100%;width: 536px;display: flex;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;width: 50px;height: 30px;border-top: 1px solid rgb(114, 114, 114);border-left: 1px solid rgb(114, 114, 114);overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<section style=\"margin-top: -20px;padding: 15px;max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\">\n<section class=\"\" style=\"padding: 10px;max-width: 100%;box-sizing: border-box;color: rgb(101, 170, 206);line-height: 25px;text-align: center;text-decoration: underline;overflow-wrap: break-word !important;\">\n<h2 class=\"rich_media_title\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzUxNTM5MDcwMA==&amp;mid=2247491596&amp;idx=1&amp;sn=60816aaa6b6f53bd56f18fcc370ed67a&amp;chksm=f9b5cd8fcec244997d8e391ff90bc9633b5338faed9405e1d51304d281c59d7468c83b675f1a&amp;scene=21#wechat_redirect\" target=\"_blank\"><span style=\"font-size: 14px;\">\u57ce\u5e02\u201c\u6b63\u7ecf\u201d\u6307\u6570<\/span><\/a><\/h2>\n<h2 class=\"\" style=\"color: rgb(101, 170, 206);text-align: center;white-space: normal;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;font-size: 14px;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzUxNTM5MDcwMA==&amp;mid=2247491221&amp;idx=1&amp;sn=63368bfc8edc89b23bc36da8e3248f93&amp;chksm=f9b63316cec1ba00ee0b681d800e4043f316e1dc3f0ce507077e182b29ae5a9f0c0fc776acc0&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5f53PROTAC\u9047\u5230D.S.Goodsell<\/a><\/span><\/h2>\n<h2 class=\"\" style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzUxNTM5MDcwMA==&amp;mid=2247490558&amp;idx=1&amp;sn=b4607457a5c9ad655d992dd2e0073faa&amp;chksm=f9b6367dcec1bf6b561e63a2e4278f92dcfd97da4bda455af806d3c993cd52019296d681a8ee&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u201c\u53e4\u7269\u201d\u5bfb\u8e2a\u2014\u2014\u8bb0\u4e8c\u4e09\u597d\u73a9\u53c8\u5c0f\u4f17\u7684\u73bb\u7483\u4eea\u5668<\/a><\/span><\/h2>\n<h2 class=\"\" style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzUxNTM5MDcwMA==&amp;mid=2247489829&amp;idx=1&amp;sn=421c2203e11efa700b2e71f3e34de0b7&amp;chksm=f9b634a6cec1bdb009d1df527008fc97b208a6162337c5782afc630a2383d86a4e3b2e4fb2ca&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u4e03\u6708\u6d41\u706b\uff1a\u6709\u5173Mars\u7684\u9050\u601d<\/a><\/span><\/h2>\n<h2 class=\"\" style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzUxNTM5MDcwMA==&amp;mid=2247488940&amp;idx=1&amp;sn=c950602b8fac2010b9eab3d6a30a43b9&amp;chksm=f9b6382fcec1b139ae004714c031a9bad8d211b0a641ff67997703fcb17fdb04b7e84a54f856&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u65e0\u7403\u4e0d\u4e50 \u65e0\u5564\u4e0d\u6b22<\/a><\/span><\/h2>\n<h2 class=\"\" style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzUxNTM5MDcwMA==&amp;mid=2247488387&amp;idx=1&amp;sn=aa426f5a59928887b7be5bf41315d3b6&amp;chksm=f9b63e00cec1b7169d13eb2742c772142d1fa835683cf3fec13e075fa617c0bdeaa8686e42bb&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5982\u4f55\u6210\u4e3a\u4e00\u540d\u4f18\u79c0\u7684\u836f\u7269\u5316\u5b66\u5bb6?<\/span><\/a><\/h2>\n<h2 class=\"\" style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzUxNTM5MDcwMA==&amp;mid=2247487879&amp;idx=1&amp;sn=cd59cbdc6fd5113d6f47ebdc157bfacd&amp;chksm=f9b63c04cec1b512e69d904f9ab2917d3a4d77dd8c6523ab0c6f5f379bfc6c785c59149afd3e&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u751c\u871c\u5c0f\u53f2\u2014\u2014\u7cd6\u4e0e\u751c\u5473\u5242<\/a><\/span><\/h2>\n<h2 class=\"\" style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzUxNTM5MDcwMA==&amp;mid=2247487392&amp;idx=1&amp;sn=91aef3f849a66c9ae40782f41de73d87&amp;chksm=f9b62223cec1ab3570157fe64c89c51cbb977ea74703d1cc24b3f737c1cd0b03d849eef46c5c&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u54f2\u4eba\u5176\u840e \u201c\u6e10\u51bb\u201d\u4e4b\u6b87<\/a><\/span><\/h2>\n<h2 class=\"\" style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzUxNTM5MDcwMA==&amp;mid=2247486591&amp;idx=1&amp;sn=57e64f7db435aa4d8d84fa3e4d79cece&amp;chksm=f9b621fccec1a8ea483245de63b31557bafdd19070230f32e27ffd799ced0aba734ae5e6fa39&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u65b0\u6625\u5bc4\u671b<\/a><\/span><\/h2>\n<h2 class=\"\" style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzUxNTM5MDcwMA==&amp;mid=2247485305&amp;idx=1&amp;sn=bde96cab81ba11fadfe99a20c79a45df&amp;chksm=f9b62afacec1a3ecdecf140d429a61591d50ca3eebb1116971478767c9b20a567a217a627929&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u751f\u547d\u4e4b\u7f8e&#8212;David S.Goodsell\u7684\u624b\u7ed8\u7ec6\u80de\u6c34\u5f69\u753b<\/a><\/span><\/h2>\n<h2 class=\"\" style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzUxNTM5MDcwMA==&amp;mid=2247486090&amp;idx=1&amp;sn=483f5ab3235558d5dd6dcb6ce87601bb&amp;chksm=f9b62709cec1ae1f6f5d27d64c021ed0117e11796a2046c23ad35af8f6bc834356a1d82a2fe9&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"color: rgb(87, 107, 149);-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">MedChemist\u7684\u81ea\u6211\u4fee\u517b\uff08App\u7bc7\uff09<\/a><\/span><\/h2>\n<h2 class=\"\" style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: 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!important;\">\n<section   style=\"max-width: 100%;box-sizing: border-box;width: 0px;display: inline-block;border-bottom: 0.8em solid rgb(121, 204, 213);overflow-wrap: break-word !important;border-left: 0.7em solid transparent !important;border-right: 0.7em solid transparent !important;\"><\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;display: inline-block;vertical-align: top;width: 133.438px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 18px;margin-bottom: 8px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;border-top: 1px dotted rgb(223, 223, 223);overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"__bg_gif\"    title=\"ALL Pain, NO Gain----\u836f\u7269\u53d1\u73b0\u4e2d\u7684\u201c\u7b5b\u9009\u5e72\u6270\u5316\u5408\u7269\u201d\" width=\"auto\"  style=\"display: inline;box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/5-1544159590.gif\" alt=\"ALL Pain, NO Gain----\u836f\u7269\u53d1\u73b0\u4e2d\u7684\u201c\u7b5b\u9009\u5e72\u6270\u5316\u5408\u7269\u201d\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"max-width: 100%;text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section class=\"\"   style=\"max-width: 100%;box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: auto;margin-left: auto;padding: 0.5em 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