{"id":73279,"date":"2018-11-30T01:00:00","date_gmt":"2018-12-07T05:14:39","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/504c50553b\/"},"modified":"2018-12-07T13:14:42","modified_gmt":"2018-12-07T05:14:42","slug":"504c50553b","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/73279\/","title":{"rendered":"STING\uff1a\u6216\u6345\u7834\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u7a97\u6237\u7eb8"},"content":{"rendered":"
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\u70b9\u51fb\u4e0a\u65b9\u7684  \u25b2 \u6dfb\u52a0\u5173\u6ce8<\/span><\/p>\n


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2018\u5e7411 \u67087\u65e5Nature \u6742\u5fd7\u520a\u53d1\u4e86\u4e00\u9879\u65b0\u6210\u679c\uff0c Joshi M. Ramanjulu \u6559\u6388\u7b4944 \u540d\u79d1\u5b66\u5bb6\uff0c\u5171\u540c\u53d1\u73b0\u4e86\u4e00\u79cd\u5c0f\u5206\u5b50 STING \uff08\u5e72\u6270\u7d20\u523a\u6fc0\u57fa\u56e0\uff09\uff0c\u8fd9\u5f88\u53ef\u80fd\u6345\u7834\u4e86\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u6700\u540e\u4e00\u5c42\u7a97\u6237\u7eb8\u3002<\/span><\/p>\n


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\"STING\uff1a\u6216\u6345\u7834\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u7a97\u6237\u7eb8\"<\/p>\n


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<\/p>\n

\"STING\uff1a\u6216\u6345\u7834\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u7a97\u6237\u7eb8\"<\/p>\n


<\/p>\n

\"STING\uff1a\u6216\u6345\u7834\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u7a97\u6237\u7eb8\"<\/p>\n

 STING\u86cb\u767d\u8bf1\u5bfcT\u7ec6\u80de\u53d1\u6325\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94<\/span><\/span><\/p>\n


<\/p>\n

STING \u6fc0\u52a8\u5242\u662f\u4e00\u79cd\u9002\u7528\u4e8e\u591a\u79cd\u764c\u75c7\u7684\u65b0\u578b\u514d\u75ab\u7597\u6cd5\u836f\u7269\uff0c\u80fd\u591f\u6fc0\u6d3b\u673a\u4f53\u7684\u9002\u5e94\u6027\u514d\u75ab\u5e94\u7b54\uff0c\u4ea7\u751f\u6301\u7eed\u7684\u6297\u80bf\u7624\u4f5c\u7528\u3002\u4e0d\u5149\u9002\u7528\u4e8e\u591a\u79cd\u764c\u75c7\uff0c\u8fd8\u6709\u671b\u589e\u5f3a\u514d\u75ab\u529f\u80fd\u7528\u4e8e\u5176\u5b83\u75be\u75c5\u7684\u6cbb\u7597\u3002\u56e0\u6b64\u57fa\u4e8eSTING\u6fc0\u52a8\u5242\u7684\u514d\u75ab\u6cbb\u7597\uff0c\u4e00\u76f4\u4e5f\u88ab\u8ba4\u4e3a\u6709\u671b\u5f7b\u5e95\u6345\u7834\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u9886\u57df\u6700\u540e\u7684\u4e00\u5c42\u7a97\u6237\u7eb8\u3002<\/span><\/p>\n


<\/p>\n

\u4eca\u5e74\uff0c\u4e3a\u4ec0\u4e48\u8bfa\u8d1d\u5c14\u751f\u7406\u6216\u533b\u5b66\u5956\u9881\u7ed9\u4e86\u4e3a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u4f5c\u51fa\u5f00\u521b\u6027\u8d21\u732e\u7684\u7f8e\u65e5\u4e24\u4f4d\u79d1\u5b66\u5bb6\uff1f<\/span><\/p>\n


<\/p>\n

\u56e0\u4e3a\u4ed6\u4eec\u5bf9\u4e8e\u514d\u75ab\u68c0\u67e5\u70b9\u4f5c\u7528\u673a\u5236\u7684\u53d1\u73b0\uff0c\u4e3a\u6574\u4e2a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u63d0\u4f9b\u4e86\u5168\u65b0\u7684\u601d\u8def\uff0c\u5e76\u6307\u660e\u4e86\u80bf\u7624\u514d\u75ab\u5b66\u7684\u53d1\u5c55\u65b9\u5411\u3002<\/span><\/p>\n


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\u5404\u4f4d\u4e5f\u8bb8\u90fd\u542c\u8bf4\u8fc7\u51e0\u4e2a\u764c\u75c7\u60a3\u8005\u653e\u5f03\u6cbb\u7597\u5374\u5947\u8ff9\u81ea\u6108\u7684\u6848\u4f8b\uff0c\u6bd4\u5982\u67d0\u67d0\u8001\u5148\u751f\u68c0\u67e5\u60a3\u4e0a\u80ba\u764c\u665a\u671f\uff0c\u533b\u751f\u8bf4\u6700\u591a\u6d3b\u4e09\u4e2a\u6708\uff0c\u8001\u5148\u751f\u5f88\u7a77\u4ed8\u4e0d\u8d77\u533b\u7597\u8d39\uff0c\u81ea\u5df1\u8fdb\u5c71\u91cc\u72ec\u5c45\uff0c\u559d\u5c71\u6cc9\u6c34\uff0c\u5403\u91ce\u679c\uff0c\u534a\u5e74\u540e\u4e0b\u5c71\u4e00\u68c0\u67e5\uff0c\u80ba\u90e8\u764c\u7ec6\u80de\u5168\u6ca1\u4e86\uff0c\u795e\u5947\u4e0d\u795e\u5947\uff1f\u5f53\u7136\u8fd8\u6709\u6e38\u51b7\u6c34\u6cf3\u6e38\u597d\u7684\uff0c\u62fc\u547d\u7ec3\u9a6c\u62c9\u677e\u81ea\u6108\u7684\u7b49\u7b49\u3002<\/span><\/p>\n


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\u79d1\u5b66\u5bb6\u4eec\u66f4\u597d\u5947\uff0c\u4e3a\u4ec0\u4e48\u6781\u5c11\u6570\u60a3\u8005\u7684\u80bf\u7624\u80fd\u591f\u81ea\u884c\u6d88\u9000\uff0c\u751a\u81f3\u5b8c\u5168\u5eb7\u590d\uff1f<\/span><\/p>\n


<\/p>\n

\u79d1\u5b66\u5bb6\u4eec\u731c\u6d4b\uff0c\u8fd9\u4e9b\u80fd\u591f\u81ea\u6108\u7684\u80bf\u7624\u60a3\u8005\uff0c\u4e00\u5b9a\u662f\u81ea\u8eab\u7684\u514d\u75ab\u529f\u80fd\u88ab\u66f4\u5927\u7a0b\u5ea6\u5730\u6fc0\u6d3b\u5e76\u53d1\u6325\u51fa\u6765\u4e86\u3002\u53ea\u8981\u4ece\u6839\u672c\u4e0a\u627e\u5230\u514d\u75ab\u673a\u5236\u66f4\u591a\u7684\u79d8\u5bc6\uff0c\u5c31\u53ef\u4ee5\u5f00\u53d1\u51fa\u6fc0\u6d3b\u5f3a\u5927\u514d\u75ab\u529f\u80fd\u5e76\u6218\u80dc\u5404\u79cd\u764c\u75c7\u7684\u7597\u6cd5\u3002<\/span><\/p>\n

\"STING\uff1a\u6216\u6345\u7834\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u7a97\u6237\u7eb8\"<\/p>\n

 STING\u86cb\u767d\u6fc0\u6d3b\u5242\u57fa\u672c\u7ed3\u6784\u548c\u7279\u5f81<\/span><\/p>\n

\u8fd9\u5176\u4e2d\uff0c\u4e00\u79cd STING \u86cb\u767d\u5f15\u8d77\u4e86\u79d1\u5b66\u5bb6\u4eec\u7684\u5174\u8da3\u3002STING \u5168\u540d\u53eb\u505a\u5e72\u6270\u7d20\u523a\u6fc0\u57fa\u56e0\uff08Stimulator of Interferon genes\uff09\uff0cSTING \u86cb\u767d\u662f\u542f\u52a8\u673a\u4f53\u5929\u7136\u514d\u75ab\u7cfb\u7edf\u62b5\u5fa1\u7ec6\u83cc\u6216\u75c5\u6bd2\u611f\u67d3\u7684\u91cd\u8981\u5206\u5b50\uff0c\u540c\u65f6\u5728\u6fc0\u6d3b\u4e0b\u6e38\u9002\u5e94\u6027\u514d\u75ab\u5e94\u7b54\u8fc7\u7a0b\u4e2d\u4e5f\u53d1\u6325\u7740\u5173\u952e\u4f5c\u7528\u3002\u7b80\u5355\u70b9\u8bf4\uff0c\u8fd9\u79cd\u86cb\u767d\u8d28\u662f\u4eba\u4f53\u6574\u4e2a\u514d\u75ab\u7cfb\u7edf\u7684\u589e\u5f3a\u6fc0\u6d3b\u5242\uff0cSTING \u86cb\u767d\u7684\u8868\u8fbe\u4e0a\u8c03\uff0c\u4f1a\u589e\u5f3a\u6574\u4e2a\u514d\u75ab\u7cfb\u7edf\u7684\u514d\u75ab\u6d3b\u6027\u3002<\/span><\/p>\n


<\/p>\n

\u4eba\u4eec\u60a3\u4e0a\u764c\u75c7\uff0c\u662f\u56e0\u4e3a\u514d\u75ab\u7ec6\u80de\u4e27\u5931\u4e86\u6d3b\u6027\uff0c\u79d1\u5b66\u5bb6\u4eec\u7ecf\u8fc7\u8270\u8f9b\u52aa\u529b\u53d1\u73b0\u4e86\u8fd9\u4e9b\u540d\u53ebCTLA4 \u3001PD-1 \u8fd9\u4e9b\u675f\u7f1a\u514d\u75ab\u7ec6\u80de\u7684\u7ef3\u7d22\uff0c\u5e76\u53d1\u660e\u4e86CTLA4 \u6291\u5236\u5242\u3001PD-1 \u6291\u5236\u5242\u6765\u780d\u65ad\u8fd9\u4e9b\u7ef3\u7d22\uff0c\u5e76\u53d1\u660e\u4e86\u706b\u70ed\u7684 CAR-T \u7597\u6cd5\uff0c\u8fd9\u4e9b\u90fd\u662f\u52a0\u5f3a\u514d\u75ab\u7cfb\u7edf\u4e2d\u514d\u75ab T \u7ec6\u80de\u5bf9\u80bf\u7624\u7684\u8bc6\u522b\u80fd\u529b\u5e76\u6740\u4f24\u4e4b\u3002\u76ee\u524d\u5df2\u7ecf\u4e0a\u5e02\u7684 O \u836f\u548c K \u836f\uff0c\u90fd\u662f\u8fd9\u7c7b\u6291\u5236\u5242\u836f\u7269\u3002<\/span><\/p>\n


<\/p>\n

\u4f46\u662f\uff0c\u8fd9\u79cd\u4f9d\u9760\u57fa\u56e0\u68c0\u6d4b\u4e3a\u6bcf\u4e00\u4f4d\u60a3\u8005\u7cbe\u51c6\u5b9a\u5236\u7684\u7ec6\u80de\u514d\u75ab\u6cbb\u7597\uff0c\u4ecd\u7136\u5b58\u5728\u7740\u5f88\u5927\u7684\u5c40\u9650\u6027\u3002\u9664\u4e86\u5b89\u5168\u6027\u4e4b\u5916\uff0c\u66f4\u5173\u952e\u7684\u95ee\u9898\u662f\uff0c\u76ee\u524d\u6bcf\u4e00\u79cd\u4e0a\u5e02\u7684\u514d\u75ab\u7597\u6cd5\u5f80\u5f80\u4ec5\u9002\u7528\u4e8e\u5c11\u6570\u764c\u79cd\u7684\u5c11\u6570\u60a3\u8005\u3002<\/span><\/p>\n


<\/p>\n

\u4e0e\u8fd9\u4e9b\u57fa\u4e8e\u6fc0\u6d3bT\u7ec6\u80de\u7684\u514d\u75ab\u7597\u6cd5\u4e0d\u540c\uff0c\u57fa\u4e8e\u6fc0\u6d3bSTING\u86cb\u767d\u6765\u589e\u5f3a\u514d\u75ab\u6548\u679c\u7684\u514d\u75ab\u6cbb\u7597\uff0c\u662f\u4ece\u66f4\u5e7f\u6cdb\u7684\u5c42\u9762\u6fc0\u6d3b\u3001\u589e\u5f3a\u4eba\u4f53\u56fa\u6709\u514d\u75ab\u7cfb\u7edf\u548c\u9002\u5e94\u6027\u514d\u75ab\u529f\u80fd\uff0c\u56e0\u6b64\u6709\u671b\u9002\u7528\u4e8e\u5404\u79cd\u764c\u79cd\u7684\u4e0d\u540c\u4eba\u7fa4\uff0c\u751a\u81f3\u7528\u4e8e\u6cbb\u7597\u764c\u75c7\u4e4b\u5916\u7684\u5176\u5b83\u75be\u75c5\u3002<\/span><\/p>\n


<\/p>\n

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\u7814\u7a76\u56e2\u961f\u901a\u8fc7\u7b5b\u9009\u591a\u4e2a\u5206\u5b50\u5e93\uff0c\u53d1\u73b0\u4e86\u4e00\u7cfb\u5217\u5177\u6709\u826f\u597d\u6d3b\u6027\u7684\u5206\u5b50\uff0c\u901a\u8fc7\u8c03\u6574\u8fd9\u4e9b\u5206\u5b50\u7684\u7279\u6027\uff0c\u4ece\u800c\u5f00\u53d1\u51fa STING \u86cb\u767d\u8d28\u7684\u6709\u6548\u6fc0\u6d3b\u5242\u3002

Joshi Ramanjulu \u6559\u6388\u8868\u793a\uff0c\u5bfb\u627e\u4e00\u79cd\u4e0e\u4f60\u6240\u5e0c\u671b\u86cb\u767d\u8d28\u76f8\u5339\u914d\u7684\u5206\u5b50\u662f\u4e00\u4e2a\u5341\u5206\u8270\u96be\u7684\u8fc7\u7a0b\u3002

\u8fd9\u4e9b\u65b0\u5206\u5b50\u7684\u6f5c\u5728\u4f18\u52bf\u4e4b\u4e00\uff0c\u662f\u5b83\u4eec\u53ef\u4ee5\u901a\u8fc7\u8840\u6db2\u6765\u8fd0\u8f93\u800c\u65e0\u9700\u76f4\u63a5\u6ce8\u5c04\u5165\u80bf\u7624\u7ec4\u7ec7\u3002\u5e76\u4e14\u7531\u4e8e\u5206\u5b50\u8d28\u91cf\u8f83\u5c0f\uff0c\u8fd9\u4e9b\u6f5c\u5728\u7684\u65b0\u836f\u8fd8\u53ef\u4ee5\u5230\u8fbe\u96be\u4ee5\u63a5\u8fd1\u7684\u5b9e\u4f53\u80bf\u7624\u4ee5\u53ca\u764c\u7ec6\u80de\u56e2\u5757\u5185\u90e8\u3002

\u7136\u540e\uff0c\u7814\u7a76\u4eba\u5458\u5c06\u65b0\u578b STING \u86cb\u767d\u6fc0\u52a8\u5242\u6ce8\u5165\u5230\u80bf\u7624\u5c0f\u9f20\u6a21\u578b\u4e2d\u8fdb\u884c\u9a8c\u8bc1\u3002\u5176\u6700\u7ec8\u7684\u7ed3\u679c\u4ee4\u6240\u6709\u7814\u7a76\u8005\u9707\u60ca\uff0c\u8fd9\u79cd\u65b0\u578b\u514d\u75ab\u6cbb\u7597\u836f\u7269\u5927\u5927\u589e\u5f3a\u4e86\u5c0f\u9f20\u673a\u4f53\u7684\u9002\u5e94\u6027\u514d\u75ab\u4f5c\u7528\uff0c\u4ea7\u751f\u6301\u7eed\u7684\u6297\u80bf\u7624\u4f5c\u7528\uff0c\u540c\u65f6\u517c\u5907\u6709\u6fc0\u6d3b\u514d\u75ab\u8bb0\u5fc6\u7ec6\u80de\u7684\u4f5c\u7528\uff0c\u80bf\u7624\u7ec4\u7ec7\u6700\u7ec8\u5b8c\u5168\u6d88\u9000\u3002
<\/span><\/p>\n


<\/p>\n

\"STING\uff1a\u6216\u6345\u7834\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u7a97\u6237\u7eb8\"<\/p>\n

 \u5c0f\u9f20\u80bf\u7624\u6301\u7eed\u51cf\u5c11\uff0c\u6700\u7ec8\u6d88\u9000<\/span><\/p>\n

\uff08\u6765\u6e90\uff1aDesign of amidobenzimidazole STING receptor agonists with systemic activity\uff09

<\/span><\/p>\n

\u79d1\u5b66\u5bb6\u4eec\u5bf9\u8fd9\u79cd\u65b0\u578b STING \u6fc0\u52a8\u5242\u7684\u6f5c\u529b\u611f\u5230\u65e0\u6bd4\u5174\u594b\u3002\u4e00\u65b9\u9762\uff0c\u9776\u5411 STING \u7684\u514d\u75ab\u673a\u5236\uff0c\u4e3a\u6574\u4e2a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7814\u7a76\u63d0\u4f9b\u4e86\u65b0\u7684\u601d\u8def\uff0c\u53e6\u4e00\u65b9\u9762\uff0c\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u7684\u65b0\u578b STING \u6fc0\u52a8\u5242\uff0c\u4e5f\u63a8\u52a8\u4e86\u65b0\u578b\u514d\u75ab\u836f\u7269\u7684\u51fa\u73b0\u548c\u4e34\u5e8a\u5e94\u7528\u3002
<\/span><\/p>\n

\u5728\u8fd9\u4e0d\u7531\u5f97\u60f3\u8d77\u4e86William Coley \u533b\u751f\u7684\u6545\u4e8b\uff1a<\/span><\/p>\n


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\u51fa\u751f\u4e8e 1862 \u5e74\u7684 William Coley \u533b\u751f\u770b\u5230\u81ea\u5df1\u5bfc\u5e08\u7559\u4e0b\u7684\u4e00\u4e2a\u795e\u5947\u75c5\u4f8b\uff1a\u4e00\u4f4d\u672f\u540e\u590d\u53d1\u7684\u80bf\u7624\u60a3\u8005\uff0c\u6bcf\u5f53\u51fa\u73b0\u4e25\u91cd\u611f\u67d3\u65f6\uff0c\u80bf\u7624\u90fd\u4f1a\u610f\u5916\u6d88\u9000\u4e00\u4e9b\uff0c\u611f\u67d3\u53cd\u590d\u53d1\u751f\u51e0\u6b21\u4e4b\u540e\u80bf\u7624\u5b8c\u5168\u6d88\u5931\u3002\u534a\u5e74\u4e4b\u540e\uff0c\u51e0\u4e4e\u653e\u5f03\u6cbb\u7597\u7684\u60a3\u8005\u7adf\u7136\u5eb7\u590d\u51fa\u9662\u3002

\u53d7\u6b64\u542f\u53d1\uff0c\u4ed6\u5f00\u59cb\u601d\u8003\u590d\u5236\u8fd9\u4f4d\u60a3\u8005\u7684\u5947\u8ff9\uff0c\u5373\u4eba\u4e3a\u5411\u80bf\u7624\u60a3\u8005\u4f53\u5185\u6ce8\u5c04\u7ec6\u83cc\u5f15\u53d1\u611f\u67d3\uff0c\u8fd9\u4e00\u7597\u6cd5\u4e5f\u88ab\u79f0\u4e3a Coley Toxin\u3002\u5728\u4e4b\u540e\u7684\u51e0\u5341\u5e74\u65f6\u95f4\u91cc\uff0cColey \u4e00\u5171\u901a\u8fc7 Coley Toxin \u6cbb\u7597\u4e86\u8d85\u8fc7\u4e00\u5343\u540d\u75c5\u4eba\uff0c\u5176\u4e2d\u6709\u5927\u7ea6 500 \u4eba\u63a5\u8fd1\u5b8c\u5168\u7f13\u89e3\u3002<\/span><\/p>\n


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\u53ef\u80fd\u662fWilliam Coley\u533b\u751f\u5bf9\u6cbb\u7597\u6280\u672f\u4e25\u683c\u4fdd\u5bc6\u7684\u539f\u56e0\uff0c\u4e16\u754c\u5404\u5730\u7684\u5176\u4ed6\u533b\u751f\u542c\u95fb\u540e\uff0c\u5374\u51e0\u4e4e\u6ca1\u6709\u4eba\u80fd\u91cd\u590d\u51fa Coley Toxin \u7684\u60ca\u4eba\u6cbb\u7597\u6548\u679c\u3002

1963 \u5e74\uff0cFDA \u5bf9\u4e34\u5e8a\u7814\u7a76\u5f00\u59cb\u5b9e\u65bd\u4e25\u683c\u7684\u76d1\u7ba1\uff0cColey Toxin \u6cbb\u7597\u5e76\u6ca1\u6709\u7ecf\u8fc7\u53cc\u76f2\u968f\u673a\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\u7684\u8bc1\u660e\uff0c\u4e5f\u5c31\u4ece\u6b64\u6d88\u5931\u5728\u6108\u53d1\u706b\u70ed\u7684\u80bf\u7624\u7814\u7a76\u6d2a\u6d41\u4e4b\u4e2d\u3002

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 William Coley \u533b\u751f\u5728\u591a\u5e74\u4ee5\u540e\u88ab\u79f0\u4e3a\u201c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u4e4b\u7236\u201d\uff0c\u6216\u8bb8\u4ed6\u5f53\u65f6\u5e76\u4e0d\u5927\u6e05\u695a\uff0c\u81ea\u5df1\u6bcf\u4e00\u6b21\u7684\u6cbb\u7597\u5c1d\u8bd5\uff0c\u90fd\u505a\u5bf9\u4e86\u4ec0\u4e48\uff0c\u505a\u9519\u4e86\u4ec0\u4e48\u3002<\/span><\/p>\n


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\u5982\u679c William Coley \u533b\u751f\u770b\u5230\u4eca\u5929\u79d1\u5b66\u5bb6\u4eec\u5bf9\u4e8e STING \u86cb\u767d\u7684\u7814\u7a76\u6210\u679c\uff0c\u6216\u8bb8\u80fd\u591f\u8c41\u7136\u5f00\u6717\u3002<\/span><\/p>\n


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\u4f46\u540c\u65f6\u4e5f\u8981\u627f\u8ba4\u8fd9\u4ec5\u4ec5\u662f\u7b2c\u4e00\u6b65\u3002\u4e00\u79cd\u65b0\u578b\u6f5c\u5728\u836f\u7269\u7684\u5f00\u53d1\uff0c\u8ddd\u79bb\u5176\u6210\u4e3a\u6807\u51c6\u7684\u4e34\u5e8a\u6cbb\u7597\u8fd8\u9700\u5f88\u591a\u5e74\u3002Joshi \u8868\u793a\uff0c\u4ed6\u4eec\u5c06\u7ee7\u7eed\u7b5b\u9009\u548c\u6539\u9020 STING \u6fc0\u6d3b\u5242\u836f\u7269\uff0c\u5e0c\u671b\u80fd\u591f\u5c3d\u5feb\u627e\u5230\u6253\u5f00\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u65b0\u5927\u95e8\u7684\u94a5\u5319\u3002<\/span><\/p>\n


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\u201c\u8d70\u8fdb\u79d1\u5b66\u201d\u5c0f\u7f16\u6ce8\uff1a\u764c\u75c7\u81ea\u6108\u7684\u4e00\u4e9b\u6545\u4e8b\u6765\u6e90\u4e8e\u5728\u533b\u9662\u5de5\u4f5c\u7684\u4eb2\u621a\u7684\u8ff0\u8bf4\uff0cSTING \u6fc0\u52a8\u5242\u7684\u539f\u7406\u6765\u6e90\u4e8e\u300a\u81ea\u7136\u300b\u6742\u5fd7\uff0cWilliam Coley\u533b\u751f\u7684\u6545\u4e8b\u6765\u6e90\u4e8e\u6c11\u95f4\u5178\u6545\u3002<\/em>
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Joshi M. Ramanjulu, G. Scott Pesiridis. Design of amidobenzimidazole STING receptor agonists with systemic activity\uff0c <\/span>DOI: 10.1038\/s41586-018-0705-y <\/span><\/em><\/span><\/p>\n<\/blockquote>\n


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\u6587\u7ae0<\/span>\u4fe1\u606f<\/span>\u6e90\u4e8e\u516c<\/span>\u4f17\u53f7<\/span>\u764c\u56fe\u817e<\/span>\uff0c<\/span>\u767b<\/span>\u8f7d\u8be5\u6587\u7ae0\u76ee\u7684\u4e3a\u66f4\u5e7f\u6cdb\u7684\u4f20\u9012\u884c\u4e1a\u4fe1\u606f\uff0c\u4e0d\u4ee3\u8868\u8d5e\u540c\u5176\u89c2\u70b9\u6216\u5bf9\u5176\u771f\u5b9e\u6027\u8d1f\u8d23\u3002\u6587\u7ae0\u7248\u6743<\/span>\u5f52\u539f\u4f5c\u8005\u53ca\u539f\u51fa\u5904\u6240\u6709\uff0c\u6587\u7ae0\u5185\u5bb9\u4ec5\u4f9b\u53c2\u8003\u3002\u672c\u7f51\u62e5\u6709\u5bf9\u6b64\u58f0\u660e\u7684\u6700\u7ec8\u89e3\u91ca\u6743\uff0c\u82e5\u65e0\u610f\u4fb5\u72af\u7248\u6743\uff0c\u8bf7\u8054\u7cfb\u5c0f\u7f16\u5220\u9664\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5fc3\u4f3c\u5e73\u539f\u8d70\u9a6c\uff0c\u6613\u653e\u96be\u6536\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u533b\u836f\u5927\u6570\u636e|\u884c\u4e1a\u52a8\u6001|\u653f\u7b56\u89e3\u8bfb<\/span><\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

\u70b9\u51fb\u4e0a\u65b9\u7684  \u25b2 \u6dfb\u52a0\u5173\u6ce8 2018\u5e7411 \u67087\u65e5Nature&nbs […]<\/p>\n","protected":false},"author":1,"featured_media":73280,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/73279"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=73279"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/73279\/revisions"}],"predecessor-version":[{"id":73287,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/73279\/revisions\/73287"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/73280"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=73279"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=73279"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=73279"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}