{"id":73325,"date":"2018-11-29T01:00:00","date_gmt":"2018-12-07T05:15:10","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/eac15d9ecd\/"},"modified":"2018-12-07T13:15:21","modified_gmt":"2018-12-07T05:15:21","slug":"eac15d9ecd","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/73325\/","title":{"rendered":"\u6297\u764c\u201c\u795e\u836f\u201d\u7f8e\u56fd\u4e0a\u5e02\uff0c\u5bf9 17 \u79cd\u764c\u6709\u6548\u7387 75%"},"content":{"rendered":"
\n

\u70b9\u51fb\u4e0a\u65b9\u7684  \u25b2 \u6dfb\u52a0\u5173\u6ce8<\/span><\/p>\n


<\/p>\n

\u4e00\u6b3e\u7cbe\u51c6\u6297\u764c\u836f\uff0c\u5728\u7f8e\u56fd FDA \u6b63\u5f0f\u4e0a\u5e02\uff01<\/span><\/p>\n

\u9488\u5bf9 17 \u79cd\u80bf\u7624<\/p>\n

\u6709\u6548\u7387\u53ef\u9ad8\u8fbe 75%\uff01<\/strong><\/p>\n

\"\u6297\u764c\u201c\u795e\u836f\u201d\u7f8e\u56fd\u4e0a\u5e02\uff0c\u5bf9<\/p>\n

\u8fd9\u662f\u6709\u53f2\u4ee5\u6765\u7b2c\u4e00\u6b3e TRK \u6291\u5236\u836f\u7269<\/strong><\/p>\n

\u7b2c\u4e00\u6b3e\u4e0e\u80bf\u7624\u7c7b\u578b\u65e0\u5173\u7684 ” \u5e7f\u8c31 ” \u6297\u764c\u836f<\/strong><\/p>\n

\u5bf9\u4e8e\u80bf\u7624\u65e0\u6cd5\u5207\u9664\uff0c\u6216\u5df2\u7ecf\u8f6c\u79fb\u7684\u665a\u671f\u60a3\u8005\u6709\u5947\u6548<\/strong><\/p>\n

\u8fd9\u65e0\u7591\u662f\u6700\u6700\u632f\u594b\u4eba\u5fc3\u7684\u91cd\u78c5\u597d\u6d88\u606f<\/p>\n

\u4eba\u7c7b\u533b\u5b66\u53f2\u4e0a\u7684\u53c8\u4e00\u4f1f\u5927\u521b\u4e3e\u548c\u4f20\u5947\uff01<\/p>\n

\"\u6297\u764c\u201c\u795e\u836f\u201d\u7f8e\u56fd\u4e0a\u5e02\uff0c\u5bf9<\/p>\n

\"\u6297\u764c\u201c\u795e\u836f\u201d\u7f8e\u56fd\u4e0a\u5e02\uff0c\u5bf9<\/p>\n

\u7f8e\u56fd\u4e0a\u5e02\u65f6\u95f4\uff1a2018 \u5e74 11 \u6708 26 \u65e5<\/span><\/p>\n

\u6279\u51c6\u5355\u4f4d\uff1a\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09<\/p>\n

\u836f\u7269\u540d\u79f0\uff1aVitrakvi\uff08\u53c8\u540d Larotrectinib\uff09<\/p>\n

\u836f\u7269\u529f\u6548\uff1a\u6709\u6548\u5bf9\u6297\u7531\u5355\u4e00\u7f55\u89c1\u57fa\u56e0\u7a81\u53d8\u9a71\u52a8\u7684\u5404\u79cd\u764c\u75c7<\/p>\n

\u9488\u5bf9\u7fa4\u4f53\uff1a\u60a3\u6709\u5b9e\u4f53\u80bf\u7624\u7684\u6210\u4eba\u548c\u513f\u7ae5\u60a3\u8005<\/p>\n

\u5236\u9020\u5546\uff1aBayer\uff08\u62dc\u8033\uff09\u548c Loxo Oncology \u5171\u540c\u7814\u53d1<\/p>\n

\"\u6297\u764c\u201c\u795e\u836f\u201d\u7f8e\u56fd\u4e0a\u5e02\uff0c\u5bf9<\/p>\n

1\u3001\u4f55\u65f6\u4e0a\u5e02\uff1f<\/strong><\/p>\n

\u6628\u5929\uff0c\u7f8e\u56fd\u65f6\u95f4 11 \u6708 26 \u65e5\uff0c\u6297\u764c\u836f\u7269 Vitrakvi \u5df2\u7ecf\u5728\u7f8e\u56fd\u6b63\u5f0f\u4e0a\u5e02\u3002<\/p>\n

Bayer \u548c Loxo Oncology \u516c\u53f8\u8054\u5408\u5ba3\u5e03\uff0cFDA \u5df2\u52a0\u901f\u6279\u51c6\u4e86\u5176\u4e0a\u5e02\u7684\u65f6\u95f4\u3002<\/p>\n

Vitrakvi \u6210\u4e3a\u4e86\u7b2c\u4e00\u4e2a\u6b63\u5f0f\u6279\u51c6\u4e0a\u5e02\u7684\u53e3\u670d TRK \u6291\u5236\u836f\u7269\uff0c\u540c\u65f6\u4e5f\u662f\u7b2c\u4e00\u4e2a\u4e0e\u80bf\u7624\u7c7b\u578b\u65e0\u5173\uff08tumor-agnostic\uff09\u7684 ” \u5e7f\u8c31 ” \u6297\u764c\u836f\u3002<\/p>\n

\u5728\u56fd\u5185\u7684\u4e0a\u5e02\u65f6\u95f4\u76ee\u524d\u5e76\u672a\u516c\u5e03\u3002\u4f46\u8fdb\u53e3\u751f\u7269\u5236\u5242\u901a\u5e38\u8981\u7ecf\u5386\u51e0\u4e2a\u6708\u5230\u51e0\u5e74\u7684\u5ba1\u6279\u65f6\u95f4\u3002<\/p>\n

\"\u6297\u764c\u201c\u795e\u836f\u201d\u7f8e\u56fd\u4e0a\u5e02\uff0c\u5bf9<\/p>\n

2\u3001\u9002\u5e94\u5e74\u9f84\uff1f<\/strong><\/p>\n

\u5a74\u513f\u81f3\u8001\u5e74\u4eba\u5747\u53ef\u9002\u7528\u3002<\/p>\n

3\u3001\u80fd\u6cbb\u7597\u4ec0\u4e48\uff1f<\/strong><\/p>\n

\u53ef\u6709\u6548\u6cbb\u7597\u7684\u7c7b\u578b\uff1a<\/p>\n

\u80ba\u764c\u3001\u7532\u72b6\u817a\u764c\u3001\u9ed1\u8272\u7d20\u7624<\/p>\n

\u80c3\u80a0\u764c\u3001\u7ed3\u80a0\u764c\u3001\u8f6f\u7ec4\u7ec7\u8089\u7624<\/p>\n

\u553e\u6db2\u817a\u3001\u5a74\u513f\u7ea4\u7ef4\u8089\u7624\u3001\u9611\u5c3e\u764c<\/p>\n

\u4e73\u817a\u764c\u3001\u80c6\u7ba1\u764c\u3001\u80f0\u817a\u764c\u7b49 17 \u79cd<\/p>\n

Vitrakvi \u7528\u4e8e\u6cbb\u7597\u643a\u5e26 NTRK \u57fa\u56e0\u878d\u5408\uff08 ( gene fusion ) \uff09\u7684\u6210\u4eba\u548c\u513f\u7ae5\uff0c\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u60a3\u8005\uff0c\u5e76\u4e14\u6ca1\u6709\u4ea7\u751f\u5df2\u77e5\u7684\u6297\u6027\u7a81\u53d8\uff0c\u662f\u8f6c\u79fb\u6027\u7684\u6216\u624b\u672f\u5207\u9664\u53ef\u80fd\u5bfc\u81f4\u4e25\u91cd\u53d1\u75c5\u7387\uff0c\u6ca1\u6709\u6709\u6548\u66ff\u4ee3\u6cbb\u7597\u65b9\u6848\u7684\u3002<\/p>\n

\"\u6297\u764c\u201c\u795e\u836f\u201d\u7f8e\u56fd\u4e0a\u5e02\uff0c\u5bf9<\/p>\n

LOXO-101 \u662f\u4e00\u4e2a\u9776\u5411\u836f\uff0c\u9488\u5bf9\u7684\u662f NTRK1\u3001NTRK2 \u6216\u8005 NTRK3 \u57fa\u56e0\u878d\u5408\u7684\u80bf\u7624\u60a3\u8005\u3002<\/span><\/p>\n

\u7b80\u5355\u6765\u8bb2\u8fd9\u4e2a\u65b0\u836f\u4e0d\u9700\u8981\u8003\u8651\u764c\u75c7\u7684\u53d1\u751f\u533a\u57df\uff0c\u8fd9\u5c31\u610f\u5473\u7740\u4e0d\u7ba1\u4ec0\u4e48\u764c\u79cd\uff08\u7ec4\u7ec7 \/ \u7ec6\u80de \/ \u90e8\u4f4d\uff09\uff0c\u53ea\u8981\u6709 NTRK \u57fa\u56e0\u878d\u5408\uff0c\u5c31\u53ef\u4ee5\u4f7f\u7528 Vitrakvi \u8fdb\u884c\u6cbb\u7597\u3002<\/p>\n

\u6240\u4ee5\uff0c\u764c\u75c7\u60a3\u8005\u53ef\u53bb\u505a\u4e00\u4e0b\u57fa\u56e0\u68c0\u6d4b\uff0c\u4e00\u5b9a\u53bb\u770b\u770b\u68c0\u6d4b\u62a5\u544a\u6709\u6ca1\u6709\u8fd9\u4e2a\u57fa\u56e0\u878d\u5408\u3002\u5982\u679c\u6709\uff0c\u90a3\u4e48\u5c31\u5f88\u6709\u53ef\u80fd\u88ab\u8be5\u836f\u7269\u6cbb\u6108\uff01<\/p>\n

\"\u6297\u764c\u201c\u795e\u836f\u201d\u7f8e\u56fd\u4e0a\u5e02\uff0c\u5bf9<\/p>\n

\"\u6297\u764c\u201c\u795e\u836f\u201d\u7f8e\u56fd\u4e0a\u5e02\uff0c\u5bf9<\/p>\n

\uff08\u6765\u6e90 FDA \u5b98\u7f51\uff09<\/span><\/p>\n

4\u3001\u591a\u4e45\u4f1a\u89c1\u6548\uff1f<\/strong><\/p>\n

\u6839\u636e FDA \u516c\u5e03\u6570\u636e\u663e\u793a\uff0c73% \u7684\u60a3\u8005\u53cd\u5e94\u65f6\u95f4\u4e3a 6 \u4e2a\u6708\u4ee5\u4e0a\uff0c63% \u7684\u60a3\u8005\u53cd\u5e94\u65f6\u95f4\u4e3a 9 \u4e2a\u6708\u4ee5\u4e0a\uff0c39% \u7684\u60a3\u8005\u53cd\u5e94\u65f6\u95f4\u4e3a 12 \u4e2a\u6708\u4ee5\u4e0a\u3002<\/p>\n

\u7f8e\u56fd FDA\uff1a” \u7cbe\u51c6\u6297\u764c\uff0c\u6709\u6548\u7387\u9ad8\u8fbe 75%”\uff01<\/strong><\/p>\n

\u6548\u679c\u5230\u5e95\u6709\u591a\u60ca\u8273\uff1f<\/strong><\/p>\n

2018 \u5e74 2 \u6708\uff0c\u4e16\u754c\u56db\u5927\u6743\u5a01\u533b\u5b66\u6742\u5fd7\u4e4b\u4e00\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\uff08NEJM\uff09\u300b\u53d1\u8868\u7684\u4e00\u9879\u5173\u4e8e\u6297\u764c\u836f Vitrakvi\uff08\u53c8\u540d larotrectinib\uff09\u7684 3 \u9879\u5b89\u5168\u6027\uff0c\u548c\u6709\u6548\u6027\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u663e\u793a :<\/p>\n

\u5bf9\u4e8e\u5e74\u9f84\u4e3a 4 \u4e2a\u6708\u81f3 76 \u5c81\u7684\u60a3\u8005\uff0c\u9488\u5bf9 17 \u79cd\u4e0d\u540c\u764c\u75c7\u6cbb\u7597\u7684\u603b\u4f53\u6709\u6548\u7387\u4e3a 75\uff05\u3002<\/p>\n

\u8fd9\u9879\u7ed3\u679c\u968f\u540e\u4e5f\u88ab FDA \u6240\u8bc1\u5b9e\u3002<\/p>\n

\"\u6297\u764c\u201c\u795e\u836f\u201d\u7f8e\u56fd\u4e0a\u5e02\uff0c\u5bf9<\/p>\n

\"\u6297\u764c\u201c\u795e\u836f\u201d\u7f8e\u56fd\u4e0a\u5e02\uff0c\u5bf9<\/p>\n

\uff08\u6765\u6e90\uff1a\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\uff09<\/span><\/p>\n

\u7d27\u63a5\u7740\uff0c2018 \u5e74 10 \u6708\u4e3e\u884c\u7684\u6b27\u6d32\u80bf\u7624\u533b\u5b66\u534f\u4f1a\u4f1a\u8bae\uff08ESMO2018\uff09\u4e0a\uff0c\u4e00\u9879\u5173\u4e8e\u6297\u764c\u836f Vitrakvi \u6cbb\u7597\u6db5\u76d6 24 \u79cd\u72ec\u7279\u80bf\u7624\u7c7b\u578b\u7684 TRK \u878d\u5408\u764c\u75c7\u6210\u4eba\uff0c\u53ca\u513f\u7ae5\u60a3\u8005\u7684\u4e34\u5e8a\u6570\u636e\u663e\u793a\uff1a<\/p>\n

\u603b\u7f13\u89e3\u7387\uff1a80%<\/p>\n

\u90e8\u5206\u7f13\u89e3\u7387\uff1a62%<\/p>\n

\u5b8c\u5168\u7f13\u89e3\u7387\uff1a18%<\/p>\n

\"\u6297\u764c\u201c\u795e\u836f\u201d\u7f8e\u56fd\u4e0a\u5e02\uff0c\u5bf9<\/p>\n

\u4ee4\u4eba\u632f\u594b\u7684\u6570\u636e\u4e0d\u6b62\u8fd9\u4e00\u70b9\uff01<\/strong><\/p>\n

\u4e0b\u9762\u8fd9\u4e9b\u662f\u4e34\u5e8a\u63a5\u53d7\u6297\u764c\u836f Vitrakvi \u6cbb\u7597\u7684\u6700\u65b0\u90e8\u5206\u6848\u4f8b\uff1a<\/strong><\/p>\n

\u80c3\u80a0\u95f4\u8d28\u7624\uff1a<\/strong><\/p>\n

55 \u5c81\u7537\u6027<\/strong><\/p>\n

\u6cbb\u7597\u524d\uff1a\u764c\u7ec6\u80de\u51e0\u4e4e\u5df2\u7ecf\u6269\u6563\u5230\u6574\u4e2a\u80a0\u80c3\u548c\u8179\u8154<\/p>\n

\u6cbb\u7597\u540e\uff1a\u63a5\u53d7\u4e86 9 \u4e2a\u5468\u671f\u6cbb\u7597\u540e\u5947\u8ff9\u51fa\u73b0\uff0c\u80bf\u7624\u660e\u663e\u7f29\u5c0f\uff0c\u76ee\u524d\u6b63\u5728\u63a5\u53d7\u7b2c 10 \u5468\u671f\u6cbb\u7597\u3002<\/p>\n

\"\u6297\u764c\u201c\u795e\u836f\u201d\u7f8e\u56fd\u4e0a\u5e02\uff0c\u5bf9<\/p>\n

\u513f\u7ae5\u7ea4\u7ef4\u8089\u7624\uff1a<\/strong><\/p>\n

16 \u4e2a\u6708\u5927\u7684\u7684\u5a74\u513f<\/strong><\/p>\n

\u6cbb\u7597\u524d\uff1a\u7ecf\u8fc7\u57fa\u56e0\u68c0\u6d4b\u540e\u53d1\u73b0 ETV6-NTRK3 \u7a81\u53d8\uff0c\u63a5\u53d7\u4e86 3 \u6b21\u624b\u672f\u548c\u5316\u7597\uff0c\u6548\u679c\u4f9d\u7136\u4e0d\u660e\u663e\u3002<\/p>\n

\u6cbb\u7597\u540e\uff1a\u63a5\u53d7\u6297\u764c\u836f Vitrakvi \u6210\u4eba\u5242\u91cf\u7684\u6db2\u4f53\u5236\u5242\u6cbb\u7597 3 \u5468\u671f\u540e\uff0cMRI \u78c1\u5171\u632f\u663e\u793a\u80bf\u7624\u4f53\u79ef\u51cf\u5c11 90\uff05\uff01<\/p>\n

\"\u6297\u764c\u201c\u795e\u836f\u201d\u7f8e\u56fd\u4e0a\u5e02\uff0c\u5bf9<\/p>\n

\u4e73\u817a\u764c\uff1a<\/strong><\/p>\n

50 \u5c81\u5973\u6027<\/strong><\/p>\n

\u6cbb\u7597\u524d\uff1a\u8fd9\u4f4d\u60a3\u8005\u4e4b\u524d\u63a5\u53d7\u8fc7\u591a\u6b21\u7684\u5316\u7597\u548c\u624b\u672f\u6cbb\u7597\uff0c\u65e0\u5948\u6700\u540e\u80bf\u7624\u8fd8\u662f\u590d\u53d1\u4e86\uff0c\u60c5\u51b5\u5f88\u4e25\u91cd<\/p>\n

\u6cbb\u7597\u540e\uff1a\u4f7f\u7528\u4e86\u6297\u764c\u836f Vitrakvi \u6cbb\u7597 20 \u5929\u4e4b\u540e\uff0c\u88f8\u9732\u7684\u80bf\u7624\u51e0\u4e4e\u6d88\u5931\u4e86\u3002<\/p>\n

\"\u6297\u764c\u201c\u795e\u836f\u201d\u7f8e\u56fd\u4e0a\u5e02\uff0c\u5bf9<\/p>\n

\u672a\u5206\u5316\u8089\u7624\uff1a<\/strong><\/p>\n

41 \u5c81\u5973\u6027<\/strong><\/p>\n

\u6cbb\u7597\u524d\uff1a\u60a3\u8005\u7684\u80bf\u7624\u7ec6\u80de\u5df2\u5e7f\u6cdb\u8f6c\u79fb\u5230\u80ba\u90e8\uff0c\u5f88\u5feb\u8981\u586b\u6ee1\u80ba\u90e8\u4e86\u3002<\/p>\n

\u6cbb\u7597\u540e\uff1a\u8fc5\u901f\u89e3\u51b3\u547c\u5438\u56f0\u96be\u548c\u4f4e\u6c27\u8840\u75c7\u30022 \u4e2a\u5468\u671f\u540e\uff0c\u5927\u90e8\u5206\u80bf\u7624\u6d88\u5931\uff0c12 \u4e2a\u5468\u671f\u540e\uff0c\u80bf\u7624\u7ec4\u7ec7\u51e0\u4e4e\u5b8c\u5168\u6d88\u5931\uff01<\/p>\n

\"\u6297\u764c\u201c\u795e\u836f\u201d\u7f8e\u56fd\u4e0a\u5e02\uff0c\u5bf9<\/p>\n

\u7ecf\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u670d\u7528\u8fd9\u6b3e\u836f\u4e5f\u4f1a\u6709\u4e00\u4e9b\u526f\u4f5c\u7528\uff0c\u5e38\u89c1\u7684\u6709\u75b2\u52b3\u3001\u6076\u5fc3\u3001\u5934\u6655\u3001\u8d2b\u8840\u3001\u54b3\u55fd\u3001\u5455\u5410\u3001\u8179\u6cfb\u7b49\u3002<\/span><\/p>\n

\u548c\u6240\u6709\u836f\u7269\u4e00\u6837\uff0c\u8fd9\u6b3e\u795e\u836f\u957f\u65f6\u95f4\u670d\u7528\u4e5f\u4f1a\u9762\u4e34\u8010\u836f\u6027\u7684\u95ee\u9898\u3002\u4f46\u636e\u62a5\u9053 Loxo \u5df2\u7ecf\u5f00\u53d1\u51fa\u7b2c\u4e8c\u4ee3 TRK \u878d\u5408\u57fa\u56e0\u7a81\u53d8\u6291\u5236\u5242 LOXO-195\uff0c\u7528\u4e8e\u6cbb\u7597\u90a3\u4e9b\u5bf9\u8fd9\u6b3e\u836f\u5df2\u7ecf\u4ea7\u751f\u8010\u836f\u6027\u7684\u60a3\u8005\u3002<\/p>\n

\u4ef7\u683c\u591a\u5c11\uff0c\u80fd\u4e0d\u80fd\u7528\u7684\u8d77\uff1f<\/strong><\/p>\n

27 \u65e5\u665a Loxo Oncology \u516c\u53f8\u4e5f\u516c\u5e03\u8fd9\u6b3e\u65b0\u836f\u7684\u4ef7\u683c\uff1a<\/p>\n

\u6210\u4eba\u80f6\u56ca\u6279\u53d1\u91c7\u8d2d\u8d39\u7528\uff1a32,800 \u7f8e\u5143\uff0c30 \u5929\u7528\u91cf<\/p>\n

\u513f\u7ae5\u53e3\u670d\u6db2\u914d\u65b9\u7684\u8d39\u7528\uff1a\u8d77\u4ef7\u4e3a\u6bcf\u6708 11,000 \u7f8e\u5143\uff0c\u6839\u636e\u60a3\u8005\u7684\u8868\u9762\u79ef\u8ba1\u7b97<\/p>\n

\u9ad8\u6602\u7684\u4ef7\u683c\u4e5f\u5f15\u8d77\u4e86\u60a3\u8005\u5bb6\u5ead\u7684\u8d28\u7591\u3002<\/strong><\/p>\n

\u76ee\u524d\u62dc\u8033\u516c\u53f8\u8868\u793a\uff0c\u60a3\u8005\u4e0d\u4f1a\u8d1f\u62c5\u4e0d\u8d77\uff0c\u5927\u591a\u6570\u60a3\u8005\u7684\u6bcf\u6708\u81ea\u4ed8\u8d39\u7528\u5c06\u4e3a 20 \u7f8e\u5143\u6216\u66f4\u4f4e\u3002<\/p>\n

\u4ed6\u4eec\u516c\u53f8\u5c06\u5e2e\u52a9\u60a3\u8005\u652f\u4ed8\u6602\u8d35\u7684\u8d39\u7528\uff0c\u5e76\u5c06\u514d\u8d39\u63d0\u4f9b Vitrakvi\uff0c\u540c\u65f6\u5236\u5b9a\u4fdd\u9669\u8be6\u7ec6\u4fe1\u606f\u3002\u5982\u679c\u60a3\u8005\u8d1f\u62c5\u4e0d\u8d77\u836f\u7269\uff0c\u7531\u62dc\u8033\u8d44\u52a9\u7684\u6148\u5584\u673a\u6784\u5c06\u514d\u8d39\u63d0\u4f9b\u8be5\u836f\u7269\uff0c\u62dc\u8033\u8fd8\u627f\u8bfa\uff0c\u5982\u679c\u60a3\u8005\u5728\u6cbb\u7597\u7684\u524d 3 \u4e2a\u6708\u6ca1\u6709\u663e\u793a\u4e34\u5e8a\u6210\u6548\uff0c\u5c06\u4f1a\u9000\u8fd8\u4fdd\u9669\u516c\u53f8\u6216\u4e2a\u4eba\u7b49\u652f\u4ed8\u8005\u6240\u6709\u82b1\u8d39\u3002<\/p>\n

\"\u6297\u764c\u201c\u795e\u836f\u201d\u7f8e\u56fd\u4e0a\u5e02\uff0c\u5bf9<\/p>\n

\uff08\u6765\u6e90\uff1a\u300aForbes\u300b\uff09<\/span><\/p>\n

\u4e3a\u4f55\u80fd\u6cbb\u7597\u591a\u79cd\u4e0d\u540c\u7c7b\u578b\u7684\u80bf\u7624\uff1f<\/strong><\/p>\n

\u8fd9\u6b3e\u836f\u662f\u6709\u53f2\u4ee5\u6765\u7b2c\u4e00\u6b3e TRK \u6291\u5236\u836f\u7269\u3002<\/p>\n

TRK\uff0c\u662f\u539f\u808c\u7403\u86cb\u767d\u53d7\u4f53\u6fc0\u9176 ( tropomyosin receptor kinase ) \u662f\u8c03\u8282\u7ec6\u80de\u901a\u8baf\u548c\u80bf\u7624\u751f\u957f\u7684\u91cd\u8981\u4fe1\u53f7\u901a\u8def\uff0c\u800c NTRK \u662f\u7f16\u7801 TRK \u7684\u57fa\u56e0\u3002\u5728\u7f55\u89c1\u60c5\u51b5\u4e0b\uff0cNTRK \u57fa\u56e0\u4f1a\u4e0e\u5176\u5b83\u57fa\u56e0\u878d\u5408\uff0c\u5bfc\u81f4 TRK \u4fe1\u53f7\u901a\u8def\u4e0d\u53d7\u63a7\u5236\uff0c\u56e0\u800c\u4fc3\u8fdb\u80bf\u7624\u7684\u751f\u957f\u3002<\/p>\n

\"\u6297\u764c\u201c\u795e\u836f\u201d\u7f8e\u56fd\u4e0a\u5e02\uff0c\u5bf9<\/p>\n

\u867d\u7136\u8fd9\u4e9b\u80bf\u7624\u6765\u6e90\u4e0d\u540c\uff0c\u4ece\u8868\u9762\u4e0a\u770b\u5343\u5dee\u4e07\u522b\uff0c\u4f46\u4ece\u5206\u5b50\u751f\u7269\u5b66\u89d2\u5ea6\u6765\u770b\uff0c\u5176\u5b9e\u5b83\u4eec\u5f88\u7c7b\u4f3c\uff0c\u56e0\u4e3a\u90fd\u6709\u4e00\u4e2a\u5171\u540c\u7279\u70b9\uff1a\u643a\u5e26 TRK \u878d\u5408\u57fa\u56e0\u7a81\u53d8\uff0c\u800c\u4e14\u4f9d\u8d56\u8fd9\u4e2a\u7a81\u53d8\u57fa\u56e0\u63d0\u4f9b\u751f\u957f\u4fe1\u53f7\u3002<\/span><\/p>\n

\u6b63\u56e0\u4e3a\u5b83\u4eec\u672c\u8d28\u90fd\u4f9d\u8d56 TRK \u57fa\u56e0\uff0c\u624d\u4f1a\u90fd\u5bf9 TRK \u9776\u5411\u836f\u7269\u4ea7\u751f\u79ef\u6781\u54cd\u5e94\u3002<\/p>\n

\u591a\u5c11\u4eba\u5c06\u4f1a\u83b7\u5f97\u65b0\u751f\u7684\u5e0c\u671b\uff1f<\/strong><\/p>\n

\u636e\u7edf\u8ba1\uff0c\u5728\u7f8e\u56fd\uff0c\u6bcf\u5e74\u5927\u7ea6 2000 \u5230 3000 \u4eba\u7f79\u60a3\u4e0e NTRK \u6709\u5173\u7684\u764c\u75c7\u3002<\/p>\n

\u8fd9\u79cd\u7a81\u53d8\u5728\u5927\u591a\u6570\u5b9e\u4f53\u80bf\u7624\u7c7b\u578b\u4e2d\u53d1\u751f\u7684\u51e0\u7387\u4e0d\u5230 1%\uff0c\u4f46\u5728\u6210\u4eba\u6d8e\u817a\u764c\u548c\u5a74\u513f\u7ea4\u7ef4\u8089\u7624\u7b49\u6076\u6027\u80bf\u7624\u4e2d\u5f88\u5e38\u89c1\u3002<\/p>\n

\u80bf\u7624\u4e13\u5bb6\uff1a<\/strong><\/p>\n

\u5bf9\u80bf\u7624\u60a3\u8005\u6765\u8bf4\uff0c\u5b83\u4e0d\u662f ” \u4e07\u80fd\u94a5\u5319 “<\/strong><\/p>\n

28 \u65e5\u4e0a\u5348\uff0c\u8bb0\u8005\u4e5f\u5c31\u8fd9\u79cd ” \u5e7f\u8c31 ” \u6297\u764c\u836f\u7684\u76f8\u5173\u95ee\u9898\uff0c\u54a8\u8be2\u4e86\u6d59\u6c5f\u5927\u5b66\u533b\u5b66\u9662\u9644\u5c5e\u7b2c\u4e8c\u533b\u9662\u80bf\u7624\u5185\u79d1\u4e3b\u4efb\u533b\u5e08\u5355\u5efa\u8d1e\uff0c\u5979\u8868\u793a\uff0cVitrakvi\uff08Larotrectinib\uff09\u662f\u6709\u53f2\u4ee5\u6765\u7b2c\u4e00\u6b3e\u9488\u5bf9 TRK \u878d\u5408\u57fa\u56e0\u7a81\u53d8\u7c7b\u578b\u80bf\u7624\u7684\u53e3\u670d\u836f\u7269\uff0c\u8fd9\u5728\u80bf\u7624\u7cbe\u51c6\u836f\u7269\u6cbb\u7597\u4e0a\u5177\u6709\u91cc\u7a0b\u7891\u610f\u4e49\u3002<\/p>\n

\u4f46\u76ee\u524d\u4e3a\u6b62\uff0c\u8fd9\u4e2a\u836f\u8fd8\u4e0d\u80fd\u8bf4\u662f\u6cbb\u6108 NTRK \u878d\u5408\u57fa\u56e0\u7684\u795e\u836f\uff0c\u4e0d\u8fc7\u5bf9\u8fd9\u90e8\u5206\u7f55\u89c1\u7a81\u53d8\u60a3\u8005\u7684\u6709\u6548\u7387\u662f\u524d\u6240\u672a\u6709\u7684\uff0c\u5c5e\u4e8e\u91cc\u7a0b\u7891\u5f0f\u7684\u7a81\u7834\uff01<\/p>\n

\u4e0d\u8fc7\u8fd9\u79cd\u836f\u5bf9\u80bf\u7624\u60a3\u8005\u6765\u8bf4\uff0c\u5e76\u4e0d\u662f\u610f\u5473\u7740\u627e\u5230\u4e86 ” \u4e07\u80fd\u94a5\u5319 “\u3002\u56e0\u4e3a TRK \u878d\u5408\u57fa\u56e0\u7a81\u53d8\u7684\u53d1\u751f\u6982\u7387\u5f88\u4f4e\uff0c\u8fd9\u79cd\u7a81\u53d8\u5728\u5927\u591a\u6570\u5b9e\u4f53\u80bf\u7624\u7c7b\u578b\u4e2d\u53d1\u751f\u7684\u51e0\u7387\u4e0d\u5230 1%\uff0c\u5728\u6210\u4eba\u6d8e\u817a\u764c\u548c\u5a74\u513f\u7ea4\u7ef4\u8089\u7624\u7b49\u6076\u6027\u80bf\u7624\u4e2d\u8f83\u4e3a\u5e38\u89c1\u3002<\/p>\n

\u66f4\u4e3a\u73b0\u5b9e\u7684\u95ee\u9898\u662f\uff0c\u8be5\u836f\u7269\u7684\u6cbb\u7597\u8d39\u7528\u975e\u5e38\u6602\u8d35\uff0c\u4ece\u62a5\u9053\u8d44\u6599\u6765\u770b\uff0c\u6210\u4eba\u60a3\u8005\u4e00\u4e2a\u6708\u7684\u6cbb\u7597\u8d39\u7528\u8d85\u8fc7 3 \u4e07\u7f8e\u5143\u3002\u5728\u6ca1\u6709\u533b\u4fdd\u6216\u5546\u4e1a\u4fdd\u9669\u8986\u76d6\u7684\u524d\u63d0\u4e0b\uff0c\u5e76\u4e0d\u662f\u6bcf\u4e2a\u60a3\u8005\u90fd\u80fd\u591f\u8d1f\u62c5\u5f97\u8d77\u7684\u3002<\/p>\n

\u5355\u533b\u5e08\u8bf4\uff0cLOXO-101\uff08Vitrakvi\uff09\u662f\u4e00\u4e2a\u9776\u5411\u836f\uff0c\u9488\u5bf9\u7684\u662f NTRK1\u3001NTRK2 \u6216\u8005 NTRK3 \u57fa\u56e0\u878d\u5408\u7684\u80bf\u7624\u60a3\u8005\u3002<\/p>\n

\u7b80\u5355\u6765\u8bb2\u8fd9\u4e2a\u65b0\u836f\u4e0d\u9700\u8981\u8003\u8651\u764c\u75c7\u7684\u53d1\u751f\u533a\u57df\uff0c\u8fd9\u5c31\u610f\u5473\u7740\u4e0d\u7ba1\u4ec0\u4e48\u764c\u79cd\uff08\u7ec4\u7ec7 \/ \u7ec6\u80de \/ \u90e8\u4f4d\uff09\uff0c\u53ea\u8981\u6709 NTRK \u57fa\u56e0\u878d\u5408\uff0c\u5c31\u53ef\u4ee5\u4f7f\u7528 Vitrakvi \u8fdb\u884c\u6cbb\u7597\u3002<\/p>\n

\u764c\u75c7\u60a3\u8005\u53ef\u53bb\u505a\u4e00\u4e0b\u57fa\u56e0\u68c0\u6d4b\uff0c\u5982\u679c\u6709 NTRK \u57fa\u56e0\u878d\u5408\uff0c\u90a3\u4e48\u5e0c\u671b\u5c31\u5728\u4e0d\u8fdc\u5904\u7b49\u7740\u4f60\uff01\u6c38\u8fdc\u4e0d\u8981\u8f7b\u6613\u653e\u5f03\uff01<\/p>\n

\u80cc\u666f\u8d44\u6599\uff1a<\/strong><\/p>\n

\u76ee\u524d\u764c\u75c7\u5df2\u7ecf\u6210\u4e86\u4eba\u7c7b\u6700\u5927\u7684\u514b\u661f<\/strong><\/p>\n

\u4eca\u5e74 9 \u6708 12 \u65e5\uff0c\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u4e0b\u5c5e\u56fd\u9645\u764c\u75c7\u7814\u7a76\u673a\u6784\uff08IARC\uff09\u53d1\u5e03\u4e86 2018 \u5e74\u6700\u65b0\u5168\u7403\u764c\u75c7\u7edf\u8ba1\u6570\u636e\u300a\u5168\u7403\u764c\u75c7\u62a5\u544a\u300b\uff1a<\/p>\n

\"\u6297\u764c\u201c\u795e\u836f\u201d\u7f8e\u56fd\u4e0a\u5e02\uff0c\u5bf9<\/p>\n

2018 \u5e74\u5168\u7403\u65b0\u589e 1810 \u4e07\u4f8b\u764c\u75c7\u75c5\u4f8b\uff08\u7537\u6027 950 \u4e07\uff0c\u5973\u6027 860 \u4e07\uff09\uff0c\u6b7b\u4ea1\u4eba\u6570\u8fbe 960 \u4e07\uff08\u7537\u6027 540 \u4e07\uff0c\u5973\u6027 420 \u4e07\uff09\uff0c\u5168\u7403\u764c\u75c7\u8d1f\u62c5\u8fdb\u4e00\u6b65\u52a0\u91cd\u3002<\/span><\/p>\n

\u4e0e\u6b64\u540c\u65f6\uff0c\u5728\u300a\u4e2d\u56fd\u6076\u6027\u80bf\u7624\u5b66\u79d1\u53d1\u5c55\u62a5\u544a\uff082017 \u5e74\uff09\u300b\u4e2d\u663e\u793a\uff1a<\/p>\n

\u5168\u56fd\u6bcf\u5929\u7ea6 1 \u4e07\u4eba\u786e\u8bca\u764c\u75c7\uff0c \u6bcf\u5206\u949f\u7ea6 7 \u4eba\u786e\u8bca\u60a3\u764c\uff0c\u4ece 0 \u5c81\u5230 85 \u5c81\uff0c\u4e00\u4e2a\u4eba\u60a3\u764c\u98ce\u9669\u9ad8\u8fbe 36%\u3002\u4e2d\u56fd\u6076\u6027\u80bf\u7624\u53d1\u75c5\u4eba\u6570\u5c45\u5168\u7403\u7b2c\u4e00\uff0c\u6bcf 10 \u4e2a\u75c5\u60a3\u4e2d\u5c31\u6709 2.2 \u4e2a\u4e2d\u56fd\u4eba\uff01\u80ba\u764c\u3001\u80c3\u764c\u3001\u809d\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u548c\u98df\u7ba1\u764c\u6392\u5728\u53d1\u75c5\u7387\u524d\u4e94\u4f4d\u3002<\/p>\n

\u80ba\u764c\u3001\u4e73\u817a\u764c\u5206\u522b\u5c45\u4e2d\u56fd\u7537\u6027\u3001\u5973\u6027\u80bf\u7624\u53d1\u75c5\u9996\u4f4d\uff01<\/p>\n

<\/p>\n

\"\u6297\u764c\u201c\u795e\u836f\u201d\u7f8e\u56fd\u4e0a\u5e02\uff0c\u5bf9<\/p>\n

\"\u6297\u764c\u201c\u795e\u836f\u201d\u7f8e\u56fd\u4e0a\u5e02\uff0c\u5bf9<\/p>\n


<\/p>\n

\n
\n
\n
\n

\u6587\u7ae0<\/span>\u4fe1\u606f\u6e90\u4e8e\u516c\u4f17\u53f7<\/span>\u6297\u4f53\u5708<\/span>\uff0c<\/span>\u767b<\/span>\u8f7d\u8be5\u6587\u7ae0\u76ee\u7684\u4e3a\u66f4\u5e7f\u6cdb\u7684\u4f20\u9012\u884c\u4e1a\u4fe1\u606f\uff0c\u4e0d\u4ee3\u8868\u8d5e\u540c\u5176\u89c2\u70b9\u6216\u5bf9\u5176\u771f\u5b9e\u6027\u8d1f\u8d23\u3002\u6587\u7ae0\u7248\u6743<\/span>\u5f52\u539f\u4f5c\u8005\u53ca\u539f\u51fa\u5904\u6240\u6709\uff0c\u6587\u7ae0\u5185\u5bb9\u4ec5\u4f9b\u53c2\u8003\u3002\u672c\u7f51\u62e5\u6709\u5bf9\u6b64\u58f0\u660e\u7684\u6700\u7ec8\u89e3\u91ca\u6743\uff0c\u82e5\u65e0\u610f\u4fb5\u72af\u7248\u6743\uff0c\u8bf7\u8054\u7cfb\u5c0f\u7f16\u5220\u9664\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n


<\/p>\n

\n
\n
\n
\n
\n
\n
\n
\n
\n
\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n

\u5b66\u5982\u9006\u6c34\u884c\u821f\uff0c\u4e0d\u8fdb\u5219\u9000\uff1b<\/span><\/p>\n

\u5fc3\u4f3c\u5e73\u539f\u8d70\u9a6c\uff0c\u6613\u653e\u96be\u6536\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n
\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\"\u6297\u764c\u201c\u795e\u836f\u201d\u7f8e\u56fd\u4e0a\u5e02\uff0c\u5bf9<\/p>\n


<\/p>\n


<\/p>\n

\n
\n
\n
\n
\n

<\/span><\/p>\n<\/section>\n

\n

\u6bcf\u65e5\u66f4\u65b0 \u6b22\u8fce\u8ba2\u9605+<\/span><\/p>\n

\n


<\/p>\n

\n<\/section>\n


<\/p>\n

\u533b\u836f\u5927\u6570\u636e|\u884c\u4e1a\u52a8\u6001|\u653f\u7b56\u89e3\u8bfb<\/span><\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

\u70b9\u51fb\u4e0a\u65b9\u7684  \u25b2 \u6dfb\u52a0\u5173\u6ce8 \u4e00\u6b3e\u7cbe\u51c6\u6297\u764c\u836f\uff0c\u5728\u7f8e\u56fd FDA \u6b63\u5f0f\u4e0a\u5e02\uff01 \u9488\u5bf9 1 […]<\/p>\n","protected":false},"author":1,"featured_media":73326,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/73325"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=73325"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/73325\/revisions"}],"predecessor-version":[{"id":73348,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/73325\/revisions\/73348"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/73326"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=73325"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=73325"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=73325"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}