{"id":73349,"date":"2018-11-28T01:00:00","date_gmt":"2018-12-07T05:15:24","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/8ab20f8d57\/"},"modified":"2018-12-07T13:15:46","modified_gmt":"2018-12-07T05:15:46","slug":"8ab20f8d57","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/73349\/","title":{"rendered":"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292"},"content":{"rendered":"
\n

\u70b9\u51fb\u4e0a\u65b9\u7684  \u25b2 \u6dfb\u52a0\u5173\u6ce8<\/span><\/p>\n


<\/p>\n

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\n

\u6628\u5929\uff0c\u8fd9\u6b3e\u9488\u5bf917\u79cd\u764c\u75c7\u6709\u6548\uff0c\u8ba9\u6211\u4eec\u671f\u5f85\u4e86\u4e24\u5e74\u7684\u4f20\u5947\u6297\u764c\u836flarotrectinib\uff08LOXO-101\uff09\u7ec8\u4e8e\u83b7\u5f97FDA\u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u60a3\u6709NTRK\u57fa\u56e0\u878d\u5408\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u7684\u6210\u4eba\u548c\u513f\u7ae5\u60a3\u8005\u3002\u540c\u65f6\uff0c\u8fd9\u6b3e\u836f\u7269\u4e5f\u6709\u4e86\u81ea\u5df1\u7684\u5927\u540dVitrakvi\uff01\u5c0f\u7f16\u4e5f\u66fe\u6709\u673a\u4f1a\u53c2\u4e0e\u8fc7\u6b64\u8bfe\u9898\u7684\u65b0\u53d1\uff0c\u500d\u611f\u8363\u5e78\uff01\uff01\uff01<\/p>\n


<\/p>\n

\u8fd1\u4e24\u5e74\uff0c\u9776\u5411\u6cbb\u7597\u548c\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u53ef\u8c13\u662f\u80bf\u7624\u754c\u7814\u53d1\u548c\u5173\u6ce8\u7684\u7126\u70b9\uff0c\u81ea\u7136\uff0c\u7a81\u7834\u548c\u4e0a\u5e02\u7684\u65b0\u836f\u4e5f\u662f\u6700\u591a\u7684\uff0c\u968f\u7740\u201c\u7cbe\u51c6\u533b\u5b66\u201d\u6982\u5ff5\u7684\u65e5\u81fb\u5b8c\u5584\uff0c\u57fa\u4e8e\u7279\u5b9a\u57fa\u56e0\uff0c\u800c\u4e0d\u533a\u5206\u80bf\u7624\u6765\u6e90\u7684\u764c\u75c7\u7597\u6cd5\u5f00\u542f\u80bf\u7624\u6cbb\u7597\u7684\u65b0\u7bc7\u7ae0\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\n

1<\/strong><\/p>\n

LOXO ONCOLOGY<\/strong><\/span><\/h2>\n

\n
\n
\n
\n
\n

LOXO ONCOLOGY\u662f\u4e00\u5bb6\u65b0\u836f\u5f00\u53d1\u516c\u53f8\uff0c\u4e3b\u8981\u5f00\u53d1\u5c0f\u5206\u5b50\u9776\u5411\u836f\u7269\uff0c\u7528\u4e8e\u764c\u75c7\/\u80bf\u7624\u7684\u6cbb\u7597\u3002<\/span>Loxo Oncology, Inc.(NASDAQ:LOXO)\u521b\u7acb\u4e8e2013\u5e74\uff0c\u603b\u90e8\u4f4d\u4e8e\u7f8e\u56fd\u5eb7\u6d85\u72c4\u683c\u5dde\u65af\u5766\u798f\u5fb7\uff0c\u5168\u804c\u96c7\u545822\u4eba\uff0c\u4e3b\u8981\u5f00\u53d1\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\u7684\u5c0f\u5206\u5b50\u9776\u5411\u836f\u7269\u65b0\u836f\u3002<\/span><\/p>\n

\"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/span><\/p>\n

LOXO ONCOLOGY \u836f\u7269\u7ba1\u7ebf<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/section>\n

\"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/p>\n

\"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/p>\n

\n

2<\/strong><\/p>\n

LOXO-101<\/strong><\/span><\/h2>\n

2018\u5e7410\u670821\u65e5\u5fb7\u56fd\u6155\u5c3c\u9ed1\u4e3e\u529e\u7684\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\uff08ESMO\uff09\u5927\u4f1a\u4e0a\uff0cLOXO-101\u518d\u6b21\u516c\u5e03\u91cd\u78c5\u6570\u636e\uff1a67\u540d\u65b0\u62a5\u544a\u7684TRK\u878d\u5408\u60a3\u8005\u8868\u73b0\u51fa81\uff05\u5ba2\u89c2\u7f13\u89e3\u7387\uff0c54\u4f4dNTRK\u878d\u5408\u7a81\u53d8\u7684\u60a3\u8005\u5728\u4f7f\u7528Larotrectinib\u6cbb\u7597\u540e\uff0c17%\u60a3\u8005\u7684\u80bf\u7624\u5b8c\u5168\u6d88\u5931\uff01<\/span><\/span><\/p>\n

\u672c\u6b21ESMO\u5927\u4f1a\u4e0a\u4ecb\u7ecd\u7684\u5305\u62ec\u5bf9Loxo-101\u76841\u671f\u6210\u4eba\u8bd5\u9a8c\uff0c2\u671f\u8bd5\u9a8c\uff08NAVIGATE\uff09\u548c1\/2\u671f\u513f\u79d1\u8bd5\u9a8c\uff08SCOUT\uff09\u6cbb\u7597\u7684\u524d55\u540d\u6210\u4eba\u548c\u513f\u7ae5\u60a3\u6709TRK\u878d\u5408\u764c\u7684\u60a3\u8005\u7684\u989d\u5916\u968f\u8bbf\u3002\u8fd9\u4e9b\u60a3\u8005\u7684\u6570\u636e\u516c\u5e03\u57282018\u5e742\u6708\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u4e0a\uff0c\u6b64\u5916\u8be5\u62a5\u544a\u8fd8\u5305\u62ec\u968f\u540e\u65b0\u767b\u8bb0\u768467\u540dTRK\u878d\u5408\u60a3\u8005\u7684\u6570\u636e\u3002<\/span><\/p>\n

\"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/p>\n

<\/p>\n

\"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/p>\n

\"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/p>\n

\"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/p>\n

\"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/p>\n

\"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/p>\n

\"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/p>\n

\"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/p>\n

\"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/p>\n

\"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/p>\n

\"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/p>\n

\"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/p>\n

\"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/p>\n

\u60a3\u6709EPS15-NTRK1\u80ba\u764c\u548cCNS\u8f6c\u79fb\u7684\u60a3\u8005\u3002<\/span>\u4e00\u4f4d77\u5c81\u7684\u5973\u6027\u60a3\u6709EPS15-NTRK1 IV\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff0c\u6211\u4eec\u53ef\u4ee5\u770b\u5230\u5979\u7684\u53cc\u80ba\u6ee1\u662f\u75c5\u7076\uff0c\u5e76\u4e14\u51fa\u73b0\u4e86\u809d\u810f\u548c\u8111\u8f6c\u79fb\uff0c\u53ef\u4ee5\u8bf4\u662f\u975e\u5e38\u975e\u5e38\u665a\u671f\u4e86\uff0c<\/span>\u65e2\u5f80\u6709\u4e73\u817a\u764c\u53f2\uff1b<\/span>\u65e2\u5f80\u75c7\u72b6\u6709\u538c\u98df\uff0c\u4e4f\u529b\uff0c\u54b3\u55fd\uff0c\u9ad8\u8102\u8840\u75c7\uff1b<\/span>ECOG 1\uff1b<\/span>\u6ca1\u6709\u63a5\u53d7\u624b\u672f\uff0c\u653e\u7597\u6216\u5316\u7597\u3002<\/span>\u5f00\u59cb\u4f7f\u7528larotrectinib 100 mg BID\u5e76\u6301\u7eed\u6cbb\u7597\uff0c<\/span>\u7b2c3\u5468\u671f\u5f00\u59cb\uff1a<\/span>\u80ba\u9776\u75c5\u53d8\u8fbe\u5230\u7f13\u89e3\uff0c\u6211\u4eec\u53ef\u4ee5\u660e\u663e\u7684\u770b\u5230\u524d\u540e\u7684\u56fe\u50cf\uff0c\u75c5\u7076\u660e\u663e\u7f29\u5c0f\u4e86\uff0c<\/span>\u8111\u8f6c\u79fb\u75c5\u53d8\u663e\u793a\u7f29\u5c0f\u4e8695\uff05\uff01<\/span>\u521d\u59cb, 2018\u5e746\u67083\u5468\u671f 2018\u5e748\u6708\u3002<\/span><\/p>\n

\"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/p>\n

\u4e00\u4e2a8\u4e2a\u6708\u5927\u7684\u7537\u5a74\u60a3\u6709\u5148\u5929\u6027ETV6-NTRK3\u5a74\u513f\u7ea4\u7ef4\u8089\u7624\uff0c<\/span><\/p>\n

\u63a5\u53d7\u4e86\u5316\u7597\u96be\u4ee5\u63a7\u5236\u75c5\u60c5\uff1a<\/span><\/p>\n

    \n
  • \n

    \u957f\u6625\u65b0\u78b1\u548c\u653e\u7ebf\u83cc\u7d20<\/span><\/p>\n<\/li>\n

  • \n

    \u591a\u67d4\u6bd4\u661f\u548c\u5f02\u73af\u78f7\u9170\u80fa<\/span><\/p>\n<\/li>\n<\/ul>\n

    \u5f00\u59cb\u4f7f\u7528larotrectinib 100 mg BID\u5e76\u6301\u7eed\u6cbb\u7597\uff0c\u5728\u6cbb\u7597\u7684\u7b2c\u4e09\u5468\u671f\u7684\u7b2c\u4e00\u5929\uff0c\u5947\u8ff9\u51fa\u73b0\u4e86\uff0c\u6211\u4eec\u6e05\u6670\u7684\u770b\u5230\u5b69\u5b50\u53f3\u4fa7\u814b\u4e0b\u80f8\u58c1\u7684\u5927\u7624\u5b50\u51e0\u4e4e\u5168\u90e8\u6d88\u5931\u4e86\u3002<\/span><\/p>\n

    \u7b2c\u4e09\u5468\u671f\u7b2c\u4e00\u59298\u6708<\/span><\/p>\n

    \u8fd9\u4e24\u4f4d\u60a3\u8005\u7684\u60c5\u51b5\u90fd\u5f88\u4e25\u91cd\uff0c\u5728\u51e0\u5e74\u524d\u53ef\u80fd\u533b\u751f\u5c31\u76f4\u63a5\u653e\u5f03\u4e86\uff0c\u4f46\u662f\u5e78\u8fd0\u7684\u662f\uff0c\u73b0\u5728\u7684\u65b0\u7597\u6cd5\u8d8a\u6765\u8d8a\u591a\uff0c\u836f\u7269\u4e5f\u8d8a\u6765\u8d8a\u591a\uff0c\u53ea\u8981\u591a\u6d3b\u4e00\u5929\uff0c\u5c31\u6709\u88ab\u201c\u6cbb\u6108\u201d\u7684\u5e0c\u671b\uff0c\u6240\u4ee5\u4e00\u5b9a\u4e0d\u8981\u8f7b\u6613\u653e\u5f03\uff0c\u575a\u4fe1\uff0c\u6211\u4eec\u79bb\u653b\u514b\u764c\u75c7\u7684\u90a3\u4e00\u5929\u8d8a\u6765\u8d8a\u8fd1\u4e86\uff01<\/span><\/p>\n

    LOXO-101\uff0c\u4f60\u60f3\u77e5\u9053\u7684\u90fd\u5728\u8fd9\uff01<\/span><\/p>\n

    \"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/p>\n

    \"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/p>\n

    \"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/p>\n

     <\/p>\n


    <\/p>\n

    \u54ea\u4e9b\u60a3\u8005\u9002\u5408\uff1f<\/span><\/strong><\/p>\n

    \u8fd9\u4e2a\u9776\u5411\u836f\u4e0d\u4ec5\u7597\u6548\u663e\u8457\uff0c\u8fd8\u662f\u5e7f\u8c31\u6297\u764c\u836f\u7269\uff0c\u5bf9\u5f88\u591a\u4e0d\u540c\u80bf\u7624\u90fd\u6709\u6548\uff01\u8fd9\u4e5f\u8fd9\u4e2a\u836f\u54c1\u8fd9\u4e48\u5438\u5f15\u773c\u7403\u7684\u539f\u56e0\u3002<\/span><\/p>\n

    \u901a\u5e38\u9776\u5411\u836f\u7684\u4f7f\u7528\u662f\u5c40\u9650\u4e8e\u67d0\u79cd\u5668\u5b98\u7c7b\u578b\u7684\uff0c\u6bd4\u5982EGFR\u9776\u5411\u836f\u6613\u745e\u6c99\u4e3b\u8981\u6cbb\u7597\u80ba\u764c\uff0cHER2\u9776\u5411\u836f\u8d6b\u8d5b\u6c40\u4e3b\u8981\u6cbb\u7597\u4e73\u817a\u764c\u3002<\/span><\/p>\n

    \u56e0\u4e3a\u867d\u7136\u8fd9\u4e9b\u80bf\u7624\u6765\u6e90\u4e0d\u540c\uff0c\u8868\u9762\u770b\u8d77\u6765\u5343\u5dee\u4e07\u522b\uff0c\u4f46\u4ece\u5206\u5b50\u751f\u7269\u5b66\u89d2\u5ea6\u6765\u770b\uff0c\u5176\u5b9e\u5b83\u4eec\u5f88\u7c7b\u4f3c\uff0c\u56e0\u4e3a\u90fd\u6709\u4e00\u4e2a\u5171\u540c\u7279\u70b9\uff1a\u643a\u5e26TRK\u878d\u5408\u57fa\u56e0\u7a81\u53d8\uff0c\u800c\u4e14\u4f9d\u8d56\u8fd9\u4e2a\u7a81\u53d8\u57fa\u56e0\u63d0\u4f9b\u751f\u957f\u4fe1\u53f7\u3002<\/span><\/p>\n

    \u6700\u8fd1\uff0cPD1\u514d\u75ab\u836f\u7269\u521a\u88ab\u6279\u51c6\u7528\u4e8eMSI-H\u5206\u5b50\u7c7b\u578b\u7684\u5404\u79cd\u80bf\u7624\uff0c\u6210\u4e3a\u7b2c\u4e00\u4e2a\u201c\u5e7f\u8c31\u514d\u75ab\u836f\u7269\u201d\u3002\u4f46\u662f\uff0cLOXO-101\u5f88\u6709\u53ef\u80fd\u540e\u6765\u8005\u5c45\u4e0a\uff0c\u5e94\u8be5\u4f1a\u662f\u7b2c\u4e00\u4e2a\u4e0a\u5e02\u7684\u201c\u5e7f\u8c31\u9776\u5411\u836f\u7269\u201d\u3002<\/span><\/p>\n

    \u8fd9\u4e24\u4e2a\u4f8b\u5b50\u90fd\u8bc1\u660e\uff0c\u6709\u4e9b\u65f6\u5019\u4f7f\u7528\u57fa\u56e0\u5206\u578b\uff0c\u6bd4\u6309\u7167\u80bf\u7624\u7ec4\u7ec7\u5206\u578b\u66f4\u597d\uff0c\u66f4\u80fd\u6307\u5bfc\u4e34\u5e8a\u6cbb\u7597\uff0c\u5230\u8fbe\u6700\u4f73\u6548\u679c\u3002\u56e0\u6b64\uff0c\u53ea\u8981\u4f60\u7ecf\u8fc7\u57fa\u56e0\u68c0\u6d4b\uff0c\u5b58\u5728<\/span><\/span><\/p>\n

    NTRK1\u3001NTRK2\u6216\u8005NTRK3\u57fa\u56e0\u878d\u5408\uff0c\u7406\u8bba\u4e0a\u90fd\u662f\u9002\u5408\u7684\uff01<\/span><\/p>\n

    \u6700\u540e\uff0cRossy\u63d0\u9192\u5927\u5bb6\uff0c\u4e00\u822c\u68c0\u67e5\u878d\u5408\u57fa\u56e0\u9700\u8981\u4f7f\u7528\u4e8c\u4ee3\u57fa\u56e0\u68c0\u6d4b\u6280\u672f\u3002\u800c\u4e14\u4e00\u5b9a\u6ce8\u610f\u662fNTRK\u57fa\u56e0\u4e0e\u5176\u4ed6\u57fa\u56e0\u878d\u5408\u53d1\u751f\u7684\u7a81\u53d8\uff0c\u800c\u4e0d\u662f\u4e00\u4e2a\u968f\u4fbf\u7684\u70b9\u7a81\u53d8\u3002<\/span><\/p>\n

    \u5168\u7403\u9876\u5c16\u7684\u57fa\u56e0\u68c0\u6d4b\u516c\u53f8\u51ef\u745e\u601d\u548cFoundation Medicine\u6700\u8fd1\u4e5f\u7814\u53d1\u4e86Foundation One CDx\u7528\u4e8eNTRK\u878d\u5408\u68c0\u6d4b\uff0c\u60f3\u4e86\u89e3\u7684\u60a3\u8005\u53ef\u4ee5\u81f4\u7535\u5168\u7403\u80bf\u7624\u533b\u751f\u7f51\u533b\u5b66\u90e8\u54a8\u8be2\u3002<\/span><\/p>\n


    <\/p>\n

    \"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/span><\/p>\n

     <\/p>\n

    \u5173\u4e8eNTRK\u57fa\u56e0<\/span><\/p>\n

    NTRK\u57fa\u56e0\u5305\u542bNTRK1\u3001NTRK2\u548cNTRK3\uff0c\u5206\u522b\u8d1f\u8d23\u7f16\u7801\u539f\u808c\u51dd\u86cb\u767d\u53d7\u4f53\u6fc0\u9176(TRK)\u5bb6\u5ead\u86cb\u767dTRKA TRKB\u548cTRKC\u7684\u5408\u6210\u3002<\/span><\/p>\n

    \"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/span><\/p>\n

     <\/p>\n

    \u4e0a\u9762\u662fNTRK\u57fa\u56e0\u5bb6\u65cf\uff0c\u5305\u542bNTRK1\u3001NTRK2\u548cNTRK3\uff0c\u8fd9\u4e2a\u57fa\u56e0\u5982\u679c\u548c\u5176\u4ed6\u7684\u57fa\u56e0\u53d1\u751f\u4e86\u878d\u5408\u7a81\u53d8\uff0c\u90a3\u4e48\u5c31\u5bfc\u81f4\u4e86\u5f02\u5e38\u7684\u6d3b\u6027\uff0c\u9a71\u52a8\u4e86\u80bf\u7624\u7684\u53d1\u751f\u3002<\/span><\/p>\n

    NTRK\u5728\u591a\u79cd\u80bf\u7624\u4e2d\u90fd\u6709\u53d1\u73b0\uff0c\u867d\u7136\u5728\u5e38\u89c1\u80bf\u7624\u80ba\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u4e2d\u7684\u53d1\u75c5\u7387\u4f4e\u4e8e5%\uff0c\u4f46\u8be5\u901a\u8def\u5728\u5404\u764c\u79cd\u81f4\u75c5\u4e2d\u5171\u4eab\u3002larotrectinib\u662f\u6cbb\u7597TRK\u57fa\u56e0\u7a81\u53d8\u764c\u75c7\u60a3\u8005\u7684\u7b2c\u4e00\u9009\u62e9\u3002<\/span><\/p>\n

    \"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/span><\/p>\n

     <\/p>\n

    4<\/span><\/p>\n

    \u8010\u836f\u540e\u600e\u4e48\u529e\uff1f<\/span><\/p>\n

    \u9762\u5bf9\u4efb\u4f55\u9776\u5411\u836f\u7269\uff0c\u603b\u4f1a\u51fa\u73b0\u7684\u4e00\u4e2a\u95ee\u9898\u662f\uff1a\u4f1a\u4e0d\u4f1a\u51fa\u73b0\u8010\u836f\u73b0\u8c61\uff1f<\/span><\/p>\n

    \u4e8b\u5b9e\u4e0a\uff0c\u5df2\u7ecf\u6709\u4e00\u4e9b\u53c2\u4e0eLOXO-101\u4e34\u5e8a\u8bd5\u9a8c\u7684\u60a3\u8005\u51fa\u73b0\u4e86\u8010\u836f\u3002<\/span><\/p>\n

    \u53ef\u559c\u7684\u662f\uff0c\u73b0\u5728\u9776\u5411\u836f\u7269\u5f00\u53d1\u5f88\u65e9\u671f\uff0c\u5c31\u4f1a\u8003\u8651\u8010\u836f\u95ee\u9898\u548c\u89e3\u51b3\u65b9\u6848\u3002\u5f88\u591a\u65f6\u5019\u4e00\u4ee3\u836f\u7269\u8fd8\u6ca1\u4e0a\u5e02\uff0c\u4e8c\u4ee3\u836f\u7269\u5c31\u51c6\u5907\u597d\u4e86\u3002<\/span><\/p>\n

    \u79d1\u5b66\u5bb6\u7ecf\u8fc7\u7814\u7a76\uff0c\u53d1\u73b0LOXO-101\u8010\u836f\u673a\u7406\u548cEGFR\u60c5\u51b5\u5f88\u50cf\uff0c\u4e3b\u8981\u662f\u9776\u70b9\u672c\u8eab\uff08TRK\u57fa\u56e0\uff09\u4ea7\u751f\u4e86\u65b0\u7684\u7a81\u53d8\uff0c\u6bd4\u5982TRKA\u51fa\u73b0G595R\u7a81\u53d8\uff0c\u6216\u8005TRKC\u51fa\u73b0G623R\u7a81\u53d8\u3002<\/span><\/p>\n

    \u6839\u636e\u8fd9\u4e2a\u53d1\u73b0\uff0c\u7b2c\u4e8c\u4ee3TRK\u9776\u5411\u836f\u7269LOXO-195\u5df2\u7ecf\u51fa\u7089\uff0c\u4e13\u95e8\u6765\u5bf9\u6297\u8010\u836f\u65b0\u7a81\u53d8\u3002<\/span><\/p>\n

    \u6628\u5929\u5173\u4e8e\u7b2c\u4e8c\u4ee3TRK\u9776\u5411\u836f\u7269\u7684\u8bba\u6587\u521a\u521a\u53d1\u8868\uff0c\u6700\u521d\u7684\u4e24\u4f4d\u8010\u836f\u60a3\u8005\u5c1d\u8bd5\u65b0\u836f\u540e\uff0c\u80bf\u7624\u518d\u6b21\u5feb\u901f\u7f29\u5c0f\u3002\u6bd4\u5982\u4e0b\u9762\u8fd9\u4f4d\uff0c\u7528\u836f\u4e00\u4e2a\u6708\u540e\uff0c\u8010\u836f\u7684\u80bf\u7624\u5c31\u518d\u6b21\u51e0\u4e4e\u6d88\u5931\uff01<\/span><\/p>\n

    \"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/span><\/p>\n

     <\/p>\n

    \u8010\u836f\u540e \u4f7f\u75282\u4ee3\u836f\u4e00\u4e2a\u6708\u540e<\/span><\/p>\n

    \"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/span><\/p>\n

     <\/p>\n

    5<\/span><\/p>\n

    \u526f\u4f5c\u7528\u6709\u54ea\u4e9b\uff1f<\/span><\/p>\n

    \u5bf9\u4e8e\u80bf\u7624\u836f\u7269\uff0c\u4e00\u4e2a\u5927\u5bb6\u5f88\u5173\u6ce8\u7684\u95ee\u9898\u662f\uff1a\u6bd2\u526f\u4f5c\u7528\u4e25\u91cd\u4e48\uff1f<\/span><\/p>\n

    \u836f\u7269\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u540c\u6837\u91cd\u8981\uff0c\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf\u548c\u751f\u5b58\u65f6\u95f4\u540c\u6837\u91cd\u8981\u3002<\/span><\/p>\n

    LOXO-101\u5c55\u73b0\u7684\u7597\u6548\u56fa\u7136\u60ca\u8273\uff0c\u4f46\u5bf9\u4e8e\u719f\u6089TRK\u57fa\u56e0\uff0c\u751a\u81f3\u5f00\u53d1\u8fc7\u7c7b\u4f3c\u836f\u7269\u7684\u79d1\u5b66\u5bb6\uff0c\u8fd9\u4e2a\u836f\u5728\u4e34\u5e8a\u5c55\u73b0\u51fa\u6765\u7684\u526f\u4f5c\u7528\u5341\u5206\u8f7b\u5fae\uff0c\u8fd9\u4e5f\u7ed9\u5927\u5bb6\u5403\u4e86\u4e00\u4e2a\u5b9a\u5fc3\u4e38\u3002<\/span><\/p>\n

    TRK\u57fa\u56e0\u4e0d\u4ec5\u5bf9\u4e00\u4e9b\u764c\u7ec6\u80de\u91cd\u8981\uff0c\u5bf9\u795e\u7ecf\u7684\u751f\u957f\u548c\u529f\u80fd\u4e5f\u5f88\u91cd\u8981\u3002\u52a8\u7269\u6a21\u578b\u663e\u793a\uff0c\u6291\u5236TRK\u529f\u80fd\uff0c\u53ef\u80fd\u4f1a\u5e26\u6765\u660e\u663e\u7684\u795e\u7ecf\u6bd2\u6027\uff0c\u6bd4\u5982\u5f15\u8d77\u8fd0\u52a8\u5931\u8c03\uff08\u5171\u6d4e\u5931\u8c03\uff09\uff0c\u611f\u89c9\u5f02\u5e38\uff0c\u884c\u4e3a\u5f02\u5e38\u7b49\u3002<\/span><\/p>\n

    LOXO-101\u5e26\u6765\u4e86\u60ca\u559c\u3002\u8fd9\u6b21\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u81f3\u5c11\u77ed\u671f\u5185\uff0c\u6ca1\u6709\u53d1\u73b0\u4efb\u4f55\u660e\u663e\u7684\u4e25\u91cd\u6bd2\u526f\u4f5c\u7528\u3002<\/span><\/p>\n

    \u8fd9\u5f88\u53ef\u80fd\u4e0d\u662f\u7eaf\u7cb9\u7684\u8fd0\u6c14\uff0c\u56e0\u5728\u5f00\u53d1LOXO-101\u8fc7\u7a0b\u4e2d\uff0c\u79d1\u5b66\u5bb6\u5c31\u9488\u5bf9\u6027\u5730\u505a\u4e86\u5927\u91cf\u4f18\u5316\uff0c\u5e0c\u671b\u4fdd\u6301\u5bf9\u80bf\u7624\u7597\u6548\u7684\u540c\u65f6\uff0c\u51cf\u5c11\u5bf9\u795e\u7ecf\u7684\u6bd2\u526f\u4f5c\u7528\u3002\u6bd4\u5982\uff0c\u4ed6\u4eec\u8ba9LOXO-101\u901a\u8fc7\u8840\u8111\u5c4f\u969c\u7684\u80fd\u529b\u51cf\u5f31\uff0c\u8fd9\u6837\u5bf9\u5927\u8111\u5f71\u54cd\u5c0f\u4e00\u4e9b\u3002<\/span><\/p>\n

    \u5230\u5e95\u662f\u4f18\u5316\u8d77\u4e86\u4e3b\u8981\u4f5c\u7528\uff0c\u8fd8\u662f\u4eba\u548c\u52a8\u7269\u6a21\u578b\u6709\u672c\u8d28\u533a\u522b\uff0c\u73b0\u5728\u5f88\u96be\u8bf4\u6e05\u695a\u3002<\/span><\/p>\n

    6<\/span><\/p>\n

    \u56fd\u5185\u60a3\u8005\u5982\u4f55\u63a5\u53d7\u6cbb\u7597<\/span><\/p>\n

    \u7531\u4e8e\u8fd9\u6b3e\u201c\u6297\u764c\u795e\u836f\u201d\u8fd8\u672a\u4e0a\u5e02\uff0c\u5bf9\u4e8e\u8d70\u6295\u65e0\u8def\u7684\u764c\u75c7\u60a3\u8005\u6765\u8bf4\uff0c\u4e34\u5e8a\u8bd5\u9a8c\u662f\u4e00\u79cd\u5f88\u597d\u7684\u9009\u62e9\uff0cRossy\u627e\u5230\u4e86\u51e0\u9879\u60a3\u8005\u53ef\u7533\u8bf7\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4f46\u662f\u5165\u7ec4\u7684\u9996\u8981\u6761\u4ef6\u662f\u5148\u8fdb\u884c\u57fa\u56e0\u68c0\u6d4b\uff0c\u786e\u8ba4\u5b58\u5728NTRK\u57fa\u56e0\u7a81\u53d8\uff01\u6240\u4ee5\u5148\u53bb\u770b\u770b\u4f60\u7684\u57fa\u56e0\u68c0\u6d4b\u62a5\u544a\u5427\uff0c<\/span><\/p>\n

    1\u3001NTRK\u878d\u5408\u9633\u6027\u5b9e\u4f53\u7624\u60a3\u8005LOXO-101\uff08Larotrectinib\uff09\u7684\u7814\u7a76<\/span><\/p>\n

    \u8fd9\u662f\u4e00\u9879\u9488\u5bf9\u643a\u5e26NTRK1\uff0cNTRK2\u6216NTRK3\u878d\u5408\u57fa\u56e0\u7684\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u7684II\u671f\u591a\u4e2d\u5fc3\u5f00\u653e\u6807\u8bb0\u7814\u7a76\u3002LOXO-101\u5c06\u4ee5100mg\u6bcf\u65e5\u4e24\u6b21\uff08BID\uff09\u53e3\u670d\u7ed9\u836f\uff0c\u8fde\u7eed\u7ed9\u836f28\u5929\u4e3a1\u5468\u671f\u3002<\/span><\/p>\n

    \u8be5\u7814\u7a76\u5c06\u5206\u67908\u4e2a\u60a3\u6709NTRK\u878d\u5408\u80bf\u7624\u60a3\u8005\u7684\u961f\u5217\uff0c\u5305\u62ec\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff0c\u7532\u72b6\u817a\u764c\uff0c\u8089\u7624\uff0c\u7ed3\u80a0\u76f4\u80a0\u764c\uff0c\u553e\u6db2\u817a\u764c\uff0c\u80c6\u7ba1\u764c\u548c\u539f\u53d1\u6027CNS\u80bf\u7624\u3002<\/span><\/p>\n

    \u5b9e\u9a8c\u5730\u70b9\uff1a<\/span><\/p>\n

    1\u3001\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821<\/span><\/p>\n

    2\u3001\u9ebb\u7701\u603b\u533b\u9662<\/span><\/p>\n

    3\u3001\u65af\u5766\u798f\u5927\u5b66\u7b49<\/span><\/p>\n

    2\u3001\u53e3\u670dTRK\u6291\u5236\u5242LOXO-101\uff08Larotrectinib\uff09\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u5c0f\u513f\u5b9e\u4f53\u6216\u539f\u53d1\u6027\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u80bf\u7624<\/span><\/h1>\n

    \u8fd9\u662f\u4e00\u9879\u591a\u4e2d\u5fc3\uff0c\u5f00\u653e\u6807\u7b7e\uff0c1\/2\u671f\u7814\u7a76\uff0c\u7528\u4e8e\u665a\u671f\u5b9e\u4f53\u6216\u539f\u53d1\u6027CNS\u80bf\u7624\u7684\u513f\u79d1\u60a3\u8005\u3002LOXO-101\uff08larotrectinib\uff09\u5c06\u6bcf\u65e5\u4e24\u6b21\u53e3\u670d\uff08PO\uff09\uff08BID\uff09\uff0c\u5242\u91cf\u901a\u8fc7\u4f53\u8868\u9762\u79ef\uff08BSA\uff09\u8c03\u6574\u3002<\/span><\/p>\n

    \u5b9e\u9a8c\u5730\u70b9\uff1a1\u3001\u6ce2\u58eb\u987f\u513f\u7ae5\u533b\u9662<\/span><\/p>\n

    2\u3001\u7eaa\u5ff5\u65af\u9686\u51ef\u7279\u6797\u4e2d\u5fc3<\/span><\/p>\n

    3\u3001\u8f9b\u8f9b\u90a3\u63d0\u513f\u7ae5\u533b\u9662\u533b\u7597\u4e2d\u5fc3\u7b49<\/span><\/p>\n

    7<\/span><\/p>\n

    \u540c\u7c7b\u836f\u7269\u8fd8\u6709\u54ea\u4e9b\uff1f<\/span><\/p>\n

    \u4ee5\u4e0b\u662f\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\u5217\u51fa\u7684\u9664keytruda\u5916\uff0c6\u79cd\u503c\u5f97\u671f\u5f85\u7684\u4e0d\u533a\u5206\u7ec4\u7ec7\u6765\u6e90\u7684\u91cd\u78c5\u6297\u764c\u836f\u7269\u53ca\u7814\u53d1\u8fdb\u5c55\uff0c\u8be6\u60c5\u70b9\u51fb\uff1a\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\u516c\u5e03\u516d\u79cd\u503c\u5f97\u671f\u5f85\u7684\u764c\u75c7\u91cd\u78c5\u65b0\u836f\uff01<\/span><\/p>\n

    \"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/span><\/p>\n

     <\/p>\n

    \n

    3<\/strong><\/p>\n

    LOXO-292<\/strong><\/span><\/h2>\n

    \n
    \n
    \n
    \n
    \n

    \u4eca\u5e74\uff0cLoxo Oncology\u516c\u53f8\u5ba3\u5e03\uff0c\u7f8e\u56fdFDA\u6388\u4e88\u8be5\u516c\u53f8\u7684\u5728\u7814\u836f\u7269LOXO-292\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff0c\u7528\u4e8e\u6cbb\u7597\u643a\u5e26RET\u57fa\u56e0\u53d8\u5f02\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u548c\u7532\u72b6\u817a\u9ad3\u6837\u764c\uff08MTC\uff09\u60a3\u8005\u3002\u8fd9\u6b3e\u65b0\u836f\u7684\u6548\u679c\u6beb\u4e0d\u900a\u8272\u4e8e\u201c\u4f20\u5947\u201d\u6297\u764c\u836fLoxo-101\uff0c\u53d6\u5f97\u4e8677%\u7684\u603b\u4f53\u7f13\u89e3\u7387\uff01\u8ba9\u66f4\u591a\u7684\u80bf\u7624\u60a3\u8005\u770b\u5230\u4e86\u5e0c\u671b\uff01<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


    <\/p>\n

    \n
    \n
    \n
    \n
    \n

    LOXO-292\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff01<\/p>\n<\/section>\n<\/section>\n


    <\/section>\n<\/section>\n<\/section>\n<\/section>\n


    <\/p>\n

    \u201c\u7a81\u7834\u6027\u7597\u6cd5\u201d\u662f\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\uff08FDA)\u521b\u5efa\uff0c \u65e8\u5728\u52a0\u901f\u5f00\u53d1\u53ca\u5ba1\u67e5\u6cbb\u7597\u4e25\u91cd\u7684\u6216\u5a01\u80c1\u751f\u547d\u7684\u75be\u75c5\u7684\u65b0\u836f\u3002\u83b7\u5f97\u201c\u7a81\u7834\u6027\u836f\u7269\u201d\u8ba4\u8bc1\u7684\u836f\u7269\u5f00\u53d1\u80fd\u5f97\u5230\u5305\u62ecFDA\u9ad8\u5c42\u5b98\u5458\u5728\u5185\u7684\u66f4\u52a0\u5bc6\u5207\u7684\u6307\u5bfc\uff0c\u4fdd\u969c\u5728\u6700\u77ed\u65f6\u95f4\u5185\u4e3a\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002<\/span><\/p>\n


    <\/p>\n

    LOXO-292\u7684\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u662f\u57fa\u4e8e\u6b63\u5728\u8fdb\u884c\u4e2d\u7684\u5168\u7403\u6027\u4e34\u5e8a1\/2\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4e2d\u671f\u7ed3\u679c\u3002\u5728\u8fd9\u9879\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u603b\u8ba182\u540d\u60a3\u8005\u63a5\u53d7\u4e86\u4e0d\u540c\u5242\u91cf\u7684LOXO-292\u6cbb\u7597\u3002\u8fd9\u4e9b\u60a3\u8005\u4e2d\u670949\u540d\u643a\u5e26RET\u878d\u5408\u9633\u6027\u80bf\u7624\uff0c29\u540d\u643a\u5e26RET\u7a81\u53d8\u9633\u6027MTC\u3002\u4ed6\u4eec\u4e2d\u5927\u591a\u6570\u90fd\u63a5\u53d7\u8fc7\u5176\u5b83\u86cb\u767d\u6fc0\u9176\u6291\u5236\u5242\u7684\u524d\u671f\u6cbb\u7597\u3002<\/span><\/p>\n


    <\/p>\n

    \u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0c<\/span>\u5728\u643a\u5e26RET\u878d\u5408\u9633\u6027\u80bf\u7624\u7684\u60a3\u8005\u4e2d\uff0cLOXO-292\u7597\u6cd5\u7684\u603b\u7f13\u89e3\u7387\u8fbe\u523077%<\/span><\/strong>\u3002<\/span>\u5728\u643a\u5e26RET\u7a81\u53d8\u9633\u6027\u7684MTC\u60a3\u8005\u4e2d\uff0c\u8be5\u7597\u6cd5\u7684\u603b\u7f13\u89e3\u7387\u8fbe\u523045%<\/strong><\/span>\u3002 <\/span><\/p>\n

    \n
    \n
    \n
    \n
    \n

    \u9776\u5411RET\u57fa\u56e0\u53d8\u5f02\u764c\u75c7\uff01<\/p>\n<\/section>\n<\/section>\n


    <\/section>\n<\/section>\n<\/section>\n<\/section>\n


    <\/p>\n

    \u7f16\u7801RET\u86cb\u767d\u6fc0\u9176\u7684RET\u57fa\u56e0\u4e0a\u51fa\u73b0\u7684\u53d8\u5f02\u5305\u62ec\u6fc0\u6d3b\u6027\u70b9\u7a81\u53d8\u548c\u878d\u5408\uff0c\u8fd9\u4e9b\u53d8\u5f02\u4f1a\u5bfc\u81f4RET\u4fe1\u53f7\u901a\u8def\u8fc7\u5ea6\u6fc0\u6d3b\u548c\u7ec6\u80de\u4e0d\u53d7\u63a7\u5236\u5730\u589e\u6b96\u3002RET\u878d\u5408\u5927\u7ea6\u57282%\u7684NSCLC\uff0c10-20%\u7684\u7532\u72b6\u817a\u764c\uff0c\u548c\u5176\u5b83\u79cd\u7c7b\u7684\u764c\u75c7\u4e9a\u578b\u4e2d\u51fa\u73b0\u3002\u800c\u6fc0\u6d3b\u6027RET\u70b9\u7a81\u53d8\u51fa\u73b0\u572860%\u7684MTC\u4e2d\u3002\u643a\u5e26RET\u878d\u5408\u7684\u764c\u75c7\u548cRET\u7a81\u53d8\u7684MTC\u4e3b\u8981\u4f9d\u9760\u8fd9\u4e00\u6fc0\u6d3b\u7684\u86cb\u767d\u6fc0\u9176\u7ef4\u6301\u5b83\u4eec\u7684\u589e\u6b96\u548c\u751f\u5b58\u3002\u8fd9\u79cd\u4f9d\u8d56\u6027\u79f0\u4e3a\u201c\u764c\u57fa\u56e0\u6210\u763e\u201d\uff0c\u8ba9\u8fd9\u4e9b\u80bf\u7624\u5bf9\u9776\u5411RET\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5242\u5f02\u5e38\u654f\u611f\u3002<\/span><\/p>\n


    <\/p>\n

    LOXO-292\u662fLoxo Oncology\u516c\u53f8\u5f00\u53d1\u7684\u53e3\u670d\u7279\u5f02\u6027RET\u6291\u5236\u5242\u3002\u5b83\u4e0d\u4f46\u80fd\u591f\u6709\u6548\u6291\u5236\u5929\u7136RET\u4fe1\u53f7\u901a\u8def\uff0c\u800c\u4e14\u80fd\u591f\u6291\u5236\u80bf\u7624\u7ec6\u80de\u4ea7\u751f\u7684\u836f\u7269\u6297\u6027\u673a\u5236\uff0c\u800c\u540e\u8005\u901a\u5e38\u662f\u9650\u5236RET\u6291\u5236\u5242\u7597\u6cd5\u7597\u6548\u7684\u91cd\u8981\u539f\u56e0\u3002<\/span><\/p>\n


    <\/p>\n

    \n
    \n
    \n
    \n
    \n

    LOXO-292  LIBRETTO-001\u8bd5\u9a8c\u6570\u636e<\/span><\/span><\/p>\n<\/section>\n<\/section>\n


    <\/section>\n<\/section>\n<\/section>\n<\/section>\n


    <\/p>\n

    LOXO-292\u7684I\u671fLIBRETTO\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0cLOXO-292\u5bf9RET\u878d\u5408\u9633\u6027\u7684\u5b9e\u4f53\u7624\u4e2d\u8868\u73b0\u51fa\u5f3a\u5927\u7684\u4e34\u5e8a\u6d3b\u6027\u3002<\/span>
    <\/p>\n


    <\/p>\n

    \u4e34\u5e8a\u8bbe\u8ba1\uff1a<\/span><\/strong><\/span><\/p>\n

    \u5171\u670982\u540d\u60a3\u8005\u63a5\u53d7\u4e867\u7ec4LOXO-292\u6cbb\u7597\uff0c\u5242\u91cf\u8303\u56f4\u4ece\u6bcf\u592920mg\u5230240mg\uff0c\u6bcf\u5929\u4e24\u6b21\u3002\u8be5\u7814\u7a76\u62db\u52df\u7684\u60a3\u8005\u5747\u4e3aRET\u878d\u5408\u9633\u6027\u764c\u75c7\u60a3\u8005\u6216RET\u7a81\u53d8\u60a3\u8005\u3002\u4e3aRET\u878d\u5408\u9633\u6027\u5305\u62ec38\u4f8bNSCLC\u60a3\u8005\uff0c9\u4f8b\u7532\u72b6\u817a\u4e73\u5934\u72b6\u764c\uff0c2\u4f8b\u80f0\u817a\u764c\u3002RET\u7a81\u53d8\u7ec4\u4ec5\u5305\u62ec\u7532\u72b6\u817a\u9ad3\u6837\u764c\u60a3\u8005\uff08n = 29\uff09\u3002<\/span><\/p>\n


    <\/p>\n

    \u8bd5\u9a8c\u7ed3\u679c\uff1a<\/span><\/strong><\/span><\/p>\n

    \u5728\u5e26\u6709RET\u878d\u5408\u53d8\u5f02\u7684\u60a3\u8005\u4e2d\uff0cLOXO-292\u7684\u603b\u4f53\u7f13\u89e3\u7387\u4e3a77%\u3002\u5176\u4e2d\uff0c\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u603b\u4f53\u7f13\u89e3\u7387\u4e5f\u4e3a77%\u3002\u800c\u5728RET\u53d8\u5f02\u7684\u7532\u72b6\u817a\u9ad3\u6837\u764c\u4e2d\uff0c\u8fd9\u6b3e\u5728\u7814\u65b0\u836f\u7684\u603b\u4f53\u7f13\u89e3\u7387\u4e3a45%\u3002\u6b64\u5916\uff0c\u8fd9\u6b3e\u65b0\u836f\u8fd8\u5c55\u73b0\u51fa\u4e86\u6301\u4e45\u7684\u7597\u6548\u3002\u9996\u540d\u53c2\u4e0e\u6b64\u7814\u7a76\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\uff0c\u6301\u7eed\u7f13\u89e3\u65f6\u95f4\u5df2\u7ecf\u8d85\u8fc7\u4e8610\u4e2a\u6708\u3002<\/span><\/p>\n


    <\/p>\n


    <\/p>\n

    \"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/p>\n


    <\/p>\n


    <\/p>\n

    \"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/p>\n

    \u6bcf\u4e2a\u67f1\u5b50\u4ee3\u8868\u4e00\u4f4d\u60a3\u8005\uff0c\u4e00\u517136\u4f4d\u60a3\u8005\uff0c\u5305\u62ec27\u4f4d\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08\u84dd\u8272\uff09\u30017\u4f4d\u7532\u72b6\u817a\u764c\uff08\u7ea2\u8272\uff09\u548c2\u4f4d\u80f0\u817a\u764c\uff08\u9ec4\u8272\uff09\uff0c\u90fd\u6709RET\u57fa\u56e0\u878d\u5408\uff1b\u67f1\u5b50\u5411\u4e0b\u4ee3\u8868\u80bf\u7624\u7f29\u5c0f\uff0c\u53ef\u4ee5\u770b\u5230\u9664\u4e86\u7b2c\u4e00\u6839\u67f1\u5b50\uff0c\u5176\u4f5935\u6839\u90fd\u662f\u671d\u4e0b\u7684\uff0c\u4ee3\u8868\u7740\u51e0\u4e4e\u6240\u6709\u7684\u80bf\u7624\u90fd\u5728\u7f29\u5c0f\u3002<\/span><\/strong><\/span><\/p>\n


    <\/p>\n


    <\/p>\n

    \u526f\u4f5c\u7528\uff1a<\/span><\/strong><\/span><\/p>\n

    82\u4f4d\u60a3\u8005\u7684\u526f\u4f5c\u7528\u7edf\u8ba1\u7ed3\u679c\uff1a\u51e0\u4e4e\u6240\u6709\u7684\u526f\u4f5c\u7528\u90fd\u662f1-2\u7ea7\uff0c\u57fa\u672c\u4e0d\u592a\u9700\u8981\u836f\u7269\u5904\u7406\uff0c\u552f\u4e00\u7684\u4e09\u7ea7\u526f\u4f5c\u7528\u662f\u547c\u5438\u56f0\u96be\uff0c\u53d1\u751f\u7684\u6bd4\u4f8b\u53ea\u67091%\uff0c\u975e\u5e38\u7684\u5b89\u5168\u3002<\/span><\/p>\n


    <\/p>\n

    \"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/p>\n

    Alexander E. Drilon<\/span><\/strong><\/span> <\/span><\/p>\n

    \u201cLOXO-292\u7684\u6d3b\u6027\u662f\u6301\u4e45\u7684\uff0c\u622a\u81f3\u622a\u6b62\u6570\u636e\u65f6\uff0c\u63a5\u8fd190\uff05\u7684\u60a3\u8005\u4ecd\u5728\u63a5\u53d7\u6cbb\u7597\uff0c\u5305\u62ec\u6240\u6709\u5bf9\u6cbb\u7597\u6709\u53cd\u5e94\u7684\u60a3\u8005\uff0c\u6700\u957f\u6cbb\u7597\u65f6\u95f4\u8d85\u8fc710\u4e2a\u6708\u201d\uff0c\u4e3b\u8981\u7814\u7a76\u4eba\u5458\u7eaa\u5ff5\u65af\u9686\u51ef\u7279\u7433\u764c\u75c7\u4e2d\u5fc3\u7684\u533b\u5b66\u80bf\u7624\u5b66\u5bb6Alexander E. Drilon \u535a\u58eb\u8bf4\u3002<\/span><\/p>\n

    \n
    \n
    \n
    \n
    \n

    LOXO-292\u5e26\u6765\u7684\u6297\u764c\u5947\u8ff9\uff01<\/span><\/p>\n<\/section>\n<\/section>\n


    <\/section>\n<\/section>\n<\/section>\n<\/section>\n
    \n
    \n


    <\/p>\n<\/section>\n<\/section>\n

    \u80ba\u764c<\/span><\/strong><\/span><\/p>\n

    2005\u5e74\uff0c\u73b0\u5e7464\u5c81\u7684\u6885\u4e3d\u838e\u514b\u52b3\u65af\u5373\u5c06\u5f00\u59cb\u65b0\u7684\u751f\u6d3b\uff0c\u56e0\u4e3a\u5979\u7684\u5b69\u5b50\u5df2\u7ecf\u53bb\u4e0a\u5927\u5b66\u4e86\uff0c\u5979\u60f3\u7533\u8bf7\u65b0\u5de5\u4f5c\u3002\u7136\u800c\u4e0d\u5e78\u7684\u662f\uff0c\u5979\u88ab\u8bca\u65ad\u60a3\u6709\u80ba\u764c\u3002\u624b\u672f\u5207\u9664\u4e86\u90e8\u5206\u5de6\u80ba\uff0c\u4e4b\u540e\u5979\u5316\u7597\u4e86\u3002\u4f46\u57282009\u5e74\uff0c\u5979\u7684\u809d\u810f\u53c8\u51fa\u73b0\u4e86\u764c\u75c7\u3002\u5979\u4ece\u90a3\u4ee5\u540e\u4e00\u76f4\u5728\u8fdb\u884c\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><\/p>\n

    \"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/p>\n

    Melissa Crouse\u5f97\u5230\u4e86\u4e00\u79cd\u65b0\u7684\u9776\u5411\u6297\u764c\u836f\u7269\u7684\u5e2e\u52a9<\/span><\/strong><\/span><\/p>\n


    <\/p>\n

    \u6700\u540e\uff0c\u5979\u8fdb\u884c\u4e86\u57fa\u56e0\u68c0\u6d4b\uff0c\u53d1\u73b0RET\u878d\u5408\u9633\u6027\uff0c\u4e8e\u662f\u5e78\u8fd0\u7684\u5165\u7ec4\u4e00\u79cd\u9488\u5bf9\u8fd9\u79cd\u9057\u4f20\u7f3a\u9677\u7684\u65b0\u836fLOXO-292\u8bd5\u9a8c\uff0c\u8fd9\u8ba9\u514b\u52b3\u65af\u7684\u80bf\u7624\u8fc5\u901f\u840e\u7f29\u3002<\/span><\/p>\n


    <\/p>\n

    \u201c\u6211\u73b0\u5728\u611f\u89c9\u6bd4\u73b0\u5728\u597d\u591a\u4e86\uff0c\u201d\u514b\u52b3\u65af\u8bf4\u3002\u5979\u53ef\u4ee5\u81ea\u5df1\u53bb\u5546\u5e97\u8d2d\u7269\uff0c\u5e2e\u5979\u7684\u5973\u513f\u7167\u770b\u4e94\u5c81\u7684\u5b59\u5973\u3002<\/span><\/p>\n

    \n
    \"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/section>\n<\/section>\n

    \u5f53\u7136\uff0c\u8fd9\u6837\u7684\u5e78\u8fd0\u8005\u4e0d\u6b62\u514b\u52b3\u65af\u4e00\u4e2a\uff1a<\/span><\/p>\n


    <\/p>\n

    40\u5c81\u7684M\u5973\u58eb\u4ece\u4e0d\u5438\u70df\uff0c\u5374\u4e0d\u5e78\u88ab\u8bca\u65ad\u4e3a\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff1a3\u7ebf\u5316\u7597\u540e\u8fdb\u884c\u4e86\u5168\u8111\u653e\u7597\u3001\u6297PD1\u6297\u4f53\u6cbb\u7597\uff0c\u6548\u679c\u5e76\u4e0d\u7406\u60f3\u3002<\/span><\/p>\n


    <\/p>\n

    M\u5973\u58eb\u8d70\u56fe\u65e0\u8def\u7684\u60c5\u51b5\u4e0b\u63a5\u53d7\u4e86\u57fa\u56e0\u68c0\u6d4b\uff0c\u53d1\u73b0\u4e86KIF5B-RET\u878d\u5408\uff0c\u5f00\u59cb\u63a5\u53d7600 mg BID\u9776\u5411\u836f alectinib\u6cbb\u7597\uff08PR\uff0c7\u4e2a\u6708\uff09\uff0c\u7531\u4e8e\u8111\u8f6c\u79fb\u8fdb\u5c55\u589e\u52a0\u81f3900mg BID\uff0c\u540e\u8111\u8f6c\u79fb\u75c7\u72b6\u4e25\u91cd\uff0cM\u5973\u58eb\u63a5\u53d7\u4e86LOXO-292\u6cbb\u7597\uff0c\u4e8e\u662f\u5947\u8ff9\u51fa\u73b0\u4e86\uff0c\u6cbb\u7597\u4e24\u4e2a\u6708\u540e\uff0cM\u5973\u58eb\u80ba\u90e8\u7684\u75c5\u7076\u660e\u663e\u597d\u8f6c\uff0c\u8111\u90e8\u75c5\u7076\u51e0\u4e4e\u5168\u90e8\u6d88\u5931\uff01<\/span><\/p>\n

    \"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/p>\n

    \"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/p>\n

    \"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/p>\n

    \n
    \"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/section>\n<\/section>\n

    \u53e6\u4e00\u4f4d52\u5c81\u7684\u80ba\u764c\u60a3\u8005\uff0c\u5316\u7597\u8010\u836f\u4e4b\u540e\u8fdb\u884c\u57fa\u56e0\u68c0\u6d4b\u53d1\u73b0\u5177\u6709KIF5B-RET\u57fa\u56e0\u878d\u5408\uff0c\u4f7f\u7528LOXO292 4\u5468\u4e4b\u540e\u80bf\u7624\u663e\u8457\u7f29\u5c0f\u3002<\/span><\/p>\n

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    61\u5c81\u7537\u6027\u8f6c\u79fb\u6027\u4f4e\u5206\u5316\u7532\u72b6\u817a\u764c;NCOA4-RET\u878d\u5408\u9633\u6027<\/span><\/p>\n

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    \"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/p>\n

    \n
    \n


    <\/p>\n

    \n
    \n
    \n
    \n
    \n

    \u54ea\u4e9b\u60a3\u8005\u9002\u5408\uff1f\uff01<\/span><\/p>\n<\/section>\n<\/section>\n


    <\/section>\n<\/section>\n<\/section>\n<\/section>\n

    \u76f8\u4fe1\u4e0a\u9762\u7684\u6570\u636e\u548c\u6848\u4f8b\u53c8\u8ba9\u4e00\u4e9b\u665a\u671f\u60a3\u8005\u770b\u5230\u4e86\u5e0c\u671b\uff0c\u4f46Rossy\u8981\u63d0\u9192\u5927\u5bb6\u7684\u662f\uff0cLOXO-292\u76ee\u524d\u6ca1\u6709\u4e0a\u5e02\uff0c\u53ea\u662f\u5728\u4e34\u5e8a\u9636\u6bb5\uff0c\u867d\u7136\u83b7\u5f97\u4e86\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u8bc1\uff0c\u8ddd\u79bb\u4e0a\u5e02\u4e5f\u8fd8\u6709\u4e0d\u77ed\u7684\u8bd5\u9a8c\u3002\u76ee\u524d\uff0c\u53ea\u6709\u901a\u8fc7\u53bb\u56fd\u5916\u53c2\u52a0\u4e34\u5e8a\u8bd5\u9a8c\u624d\u80fd\u7528\u5230\uff0c\u4f46Rossy\u5efa\u8bae\u5927\u5bb6\u5148\u63a5\u53d7\u6b63\u89c4\u7684\u6cbb\u7597\uff0c\u5728\u6ca1\u6709\u66f4\u597d\u6cbb\u7597\u65b9\u6848\u7684\u60c5\u51b5\u4e0b\u53ef\u4ee5\u8003\u8651\uff0c\u53e6\u5916\uff0c\u7531\u4e8e\u8fd9\u6b3e\u836f\u7269\u662f\u9488\u5bf9RET\u57fa\u56e0\u7684\uff0c\u6240\u4ee5\u5927\u5bb6\u505a\u8fc7\u591a\u57fa\u56e0\u68c0\u6d4b\u7684\u60a3\u8005\uff0c\u53ef\u4ee5\u5148\u770b\u770b\u662f\u5426\u6709\u8fd9\u4e2aRET\u57fa\u56e0\u7a81\u53d8\u6216\u8005\u878d\u5408\u3002\u6ca1\u505a\u8fc7\u7684\u53ef\u4ee5\u5c1d\u8bd5\u8fdb\u884c\u68c0\u6d4b\u3002\u636e\u4e86\u89e3\uff0c\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u91cc\u9762\uff0c\u5927\u7ea61%-2%\u7684\u60a3\u8005\u6709RET\u57fa\u56e0\u878d\u5408\uff0c\u5728\u7532\u72b6\u817a\u9ad3\u6837\u764c\u4e2d\u8d85\u8fc760%\u7684\u60a3\u8005\u6709RET\u57fa\u56e0\u7a81\u53d8\uff0c\u5728\u4e73\u5934\u72b6\u7532\u72b6\u817a\u764c\u4e2d10%\u7684\u60a3\u8005\u6709RET\u57fa\u56e0\u878d\u5408\u3002<\/span><\/p>\n<\/section>\n<\/section>\n

    \"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/p>\n

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    <\/p>\n

    \u6587\u7ae0\u90e8\u5206\u4fe1\u606f\u6e90\u4e8e\u516c\u4f17\u53f7\u73af\u5b87\u8fbe\u5eb7<\/span>\u5168\u7403\u4e13\u5bb6\/<\/span>\u514d\u75ab\u7ec6\u80de\u6cbb\u7597<\/span>\uff0c<\/span>\u767b\u8f7d\u8be5\u6587\u7ae0\u76ee\u7684\u4e3a\u66f4\u5e7f\u6cdb\u7684\u4f20\u9012\u884c\u4e1a\u4fe1\u606f\uff0c\u4e0d\u4ee3\u8868\u8d5e\u540c\u5176\u89c2\u70b9\u6216\u5bf9\u5176\u771f\u5b9e\u6027\u8d1f\u8d23\u3002\u6587\u7ae0\u7248\u6743\u5f52\u539f\u4f5c\u8005\u53ca\u539f\u51fa\u5904\u6240\u6709\uff0c\u6587\u7ae0\u5185\u5bb9\u4ec5\u4f9b\u53c2\u8003\u3002\u672c\u7f51\u62e5\u6709\u5bf9\u6b64\u58f0\u660e\u7684\u6700\u7ec8\u89e3\u91ca\u6743\uff0c\u82e5\u65e0\u610f\u4fb5\u72af\u7248\u6743\uff0c\u8bf7\u8054\u7cfb\u5c0f\u7f16\u5220\u9664\u3002<\/span><\/p>\n

    \n
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    \n
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    \u5b66\u5982\u9006\u6c34\u884c\u821f\uff0c\u4e0d\u8fdb\u5219\u9000\uff1b<\/span><\/p>\n

    \u5fc3\u4f3c\u5e73\u539f\u8d70\u9a6c\uff0c\u6613\u653e\u96be\u6536\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

    \n
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    <\/section>\n<\/section>\n<\/section>\n<\/section>\n
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    <\/section>\n<\/section>\n<\/section>\n
    \n
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    <\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


    <\/p>\n

    \"\u4e00\u6587\u8bfb\u61c2\u5c0f\u800c\u7f8e\u7684\u516c\u53f8\u2014\u2014LOXO-101\/292\"<\/p>\n


    <\/p>\n


    <\/p>\n

    \n
    \n
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    \n

    <\/span><\/p>\n<\/section>\n

    \n

    \u6bcf\u65e5\u66f4\u65b0 \u6b22\u8fce\u8ba2\u9605+<\/span><\/p>\n

    \n


    <\/p>\n

    \n<\/section>\n


    <\/p>\n

    \u533b\u836f\u5927\u6570\u636e|\u884c\u4e1a\u52a8\u6001|\u653f\u7b56\u89e3\u8bfb<\/span><\/p>\n


    <\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

    \u70b9\u51fb\u4e0a\u65b9\u7684  \u25b2 \u6dfb\u52a0\u5173\u6ce8 \u6628\u5929\uff0c\u8fd9\u6b3e\u9488\u5bf917\u79cd\u764c\u75c7\u6709\u6548\uff0c\u8ba9\u6211\u4eec\u671f\u5f85\u4e86\u4e24\u5e74\u7684\u4f20\u5947 […]<\/p>\n","protected":false},"author":1,"featured_media":73350,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/73349"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=73349"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/73349\/revisions"}],"predecessor-version":[{"id":73391,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/73349\/revisions\/73391"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/73350"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=73349"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=73349"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=73349"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}