{"id":73646,"date":"2018-11-22T01:00:00","date_gmt":"2018-12-07T05:18:30","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/485eca6531\/"},"modified":"2018-12-07T13:18:32","modified_gmt":"2018-12-07T05:18:32","slug":"485eca6531","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/73646\/","title":{"rendered":"CAR-T\u4e0eTCR-T\u7684\u533a\u522b\u5728\u54ea\u91cc\uff1f"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"text-align: center;\"><span style=\"color: rgb(51, 51, 51);font-family: -apple-system-font, system-ui, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 14px;letter-spacing: 0.544px;text-align: center;background-color: rgb(255, 255, 255);\">\u70b9\u51fb\u4e0a\u65b9\u7684&nbsp;&nbsp;\u25b2&nbsp;\u6dfb\u52a0\u5173\u6ce8<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: justify;\"><span 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initial;vertical-align: baseline;line-height: 26px;text-align: center;\"><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;line-height: 2;\"><\/span><span style=\"text-align: justify;border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;line-height: 2;\">\u2003\u2003<\/span><strong style=\"text-align: justify;\"><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;line-height: 2;\">\u80bf\u7624\u514d\u75ab\u6cbb\u7597\uff0c\u5b9e\u9645\u4e0a\u5206\u4e3a\u4e24\u5927\u7c7b:<\/span><\/strong><img class=\"\"     style=\"margin-top: 6px;margin-bottom: 6px;border-width: 0px;border-style: none;border-color: initial;vertical-align: middle;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/5-1544159911.jpeg\" alt=\"CAR-T\u4e0eTCR-T\u7684\u533a\u522b\u5728\u54ea\u91cc\uff1f\" title=\"CAR-T\u4e0eTCR-T\u7684\u533a\u522b\u5728\u54ea\u91cc\uff1f\"  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baseline;line-height: 2;\">\u2003\u2003\u80bf\u7624\u6d78\u6da6\u6027\u6dcb\u5df4\u7ec6\u80de\uff08TILs\uff09\u867d\u53d1\u5c55\u7f13\u6162\uff0c\u4f46\u6570\u5341\u5e74\u6765\u4e00\u76f4\u8fdb\u6b65\uff0c\u8fd1\u671f\u4e00\u9879\u9488\u5bf9\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u7684\u56fd\u9645III\u671f\u968f\u673a\u8bd5\u9a8c\u5df2\u7ecf\u5b8c\u6210\uff08https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00200577\uff09\uff0c\u8fd9\u9879\u7814\u7a76\u524d\u540e\u7ecf\u5386\u5341\u591a\u5e74\uff0c\u6700\u7ec8\u7ed3\u679c\u8fd8\u662f\u4e0d\u9519\u7684\uff0c\u4e0d\u7ba1\u5728\u590d\u53d1\u8fd8\u662f\u957f\u671f\u751f\u5b58\u65b9\u9762\uff0cTILs\u90fd\u662f\u6709\u6548\u7684\u3002\u7f16\u8005\u6309\uff1a\u53e6\u4e00\u65b9\u9762Rosenberg\u7684<\/span><br  \/><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;line-height: 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2;\">\u2003\u2003\u5d4c\u5408\u6297\u539f\u53d7\u4f53T\u7ec6\u80de\u6280\u672f\uff08CAR-T\uff09\u4ee5\u53caT\u7ec6\u80de\u53d7\u4f53\uff08TCR\uff09\u5d4c\u5408\u578bT\u7ec6\u80de\uff08TCR-T\uff09\u4f5c\u4e3a\u5f53\u524d\u8fc7\u7ee7\u6027\u7ec6\u80de\u56de\u8f93\u6cbb\u7597ACT\u6280\u672f\u4e24\u5927\u6700\u65b0\u7684\u514d\u75ab\u7ec6\u80de\u6280\u672f\uff0c\u56e0\u5176\u80fd\u591f\u8868\u8fbe\u7279\u5f02\u6027\u53d7\u4f53\u9776\u5411\u8bc6\u522b\u7279\u5f02\u6027\u7684\u7ec6\u80de\u5982\u80bf\u7624\u7ec6\u80de\uff0c\u53d7\u5230\u5e7f\u6cdb\u7684\u5173\u6ce8\u548c\u7814\u7a76\uff0c\u4ece\u6700\u5f00\u59cb\u7684\u57fa\u7840\u514d\u75ab\u7814\u7a76\u8f6c\u53d8\u4e3a\u4e34\u5e8a\u5e94\u7528\u3002\u57fa\u4e8e\u5408\u6210\u751f\u7269\u5b66\uff0c\u514d\u75ab\u5b66\uff0c\u9057\u4f20\u6539\u9020\u6280\u672f\uff0c\u4f7f\u5f97\u5408\u6210\u6539\u9020\u7684\u7279\u5f02\u6027\u529f\u80fd\u52a0\u5f3a\u7248\u7684T\u7ec6\u80de\u6210\u4e3a\u53ef\u80fd\u3002CD19\u6297\u539f\u7279\u5f02\u6027CAR-T 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2;\">\u2003\u2003T\u7ec6\u80de\u6709\u4e00\u70b9\u50cf\u6211\u4eec\u8eab\u4f53\u7684\u201c\u7eaa\u59d4\u5de1\u89c6\u7ec4\u201d\u3002\u5b83\u4eec\u5728\u808c\u4f53\u5185\u5de1\u903b\u65f6\uff0c\u4e0d\u65ad\u5730\u548c\u5404\u79cd\u7ec6\u80de\u8fdb\u884c\u201c\u4eb2\u5bc6\u201d\u63a5\u89e6\uff0c\u4ee5\u68c0\u67e5\u7ec6\u80de\u5185\u90e8\u662f\u5426\u6b63\u5e38\u3002\u800c\u8fd9\u79cd\u63a5\u89e6\u548c\u68c0\u67e5\u5de5\u4f5c\u4e3b\u8981\u662f\u901a\u8fc7\u4e00\u79cd\u79f0\u4e4b\u4e3a\u201cT\u7ec6\u80de\u53d7\u4f53\u201d\u6765\u8fdb\u884c\u7684\u3002\u7ec6\u80de\u65b9\u9762\u548c\u201cT\u7ec6\u80de\u53d7\u4f53\u201d\u4ea4\u63a5\u7684\u662f\u4e00\u7c7b\u88ab\u79f0\u4e3a\u201cMHC\u201d\uff08\u6216\u8005\u5728\u4eba\u7c7b\u88ab\u79f0\u4e3aHLA\uff09\u7684\u8868\u9762\u86cb\u767d\u3002\u8fd9\u7c7b\u86cb\u767d\u7684\u529f\u80fd\u5c31\u662f\u628a\u7ec6\u80de\u5185\u90e8\u86cb\u767d\u5206\u89e3\u540e\u7684\u7247\u6bb5\u5448\u73b0\u7ed9T\u7ec6\u80de\u3002\u4f9bT\u7ec6\u80de\u68c0\u67e5\u3002\u5982\u679cT-\u7ec6\u80de\u53d1\u73b0\u5176\u4e2d\u6709\u53d8\u5f02\u7684\u86cb\u767d\u7247\u6bb5\uff0c\u5c31\u53ef\u80fd\u5bf9\u7ec6\u80de\u53d1\u8d77\u8fdb\u653b\uff0c\u6467\u6bc1\u53d8\u5f02\u7684\u7ec6\u80de\u3002\u8fd9\u4e5f\u5c31\u662f\u6211\u4eec\u514d\u75ab\u7cfb\u7edf\u5982\u4f55\u80fd\u591f\u957f\u671f\u4fdd\u6301\u6211\u4eec\u65e0\u764c\u751f\u6d3b\u7684\u4e3b\u8981\u539f\u56e0\u3002<\/span><br  \/><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;line-height: 2;\">\u2003\u2003\u4f46\u764c\u75c7\u8fd8\u662f\u4f1a\u7ecf\u5e38\u53d1\u751f\u3002\u8fd9\u91cc\u7684\u539f\u56e0\u56fa\u7136\u5f88\u591a\uff0c\u4e5f\u5f88\u590d\u6742\u3002\u4f46\u603b\u4f53\u6765\u8bb2\uff0c\u764c\u75c7\u53d1\u751f\u8bf4\u660e\u6211\u4eec\u7684T\u7ec6\u80de\u5df2\u7ecf\u5931\u53bb\u4e86\u8bc6\u522b\u764c\u7ec6\u80de\u4ee5\u53ca\u6467\u6bc1\u764c\u7ec6\u80de\u7684\u80fd\u529b\u3002\u800c\u63d0\u9ad8T\u7ec6\u80de\u8bc6\u522b\u80fd\u529b\u7684\u5173\u952e\u5c31\u5728\u4e8e\u6539\u8fdb\u201cT\u7ec6\u80de\u53d7\u4f53\u201d\u3002\u4ece\u8fd9\u4e2a\u89d2\u5ea6\u53bb\u601d\u8003\uff0c\u5c31\u4ea7\u751f\u4e86\u6211\u4eec\u521a\u521a\u63d0\u5230\u7684\u8fd9\u4e24\u79cd\u7ec6\u80de\u514d\u75ab\u6cbb\u7597\u6280\u672f\uff1aCAR-T\u548c\u57fa\u56e0\u4fee\u6539\u7684T\u7ec6\u80de\u53d7\u4f53\u3002<\/span><br  \/><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;line-height: 2;\">\u2003\u2003<\/span><strong><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;color: rgb(229, 51, 51);line-height: 2;\">CAR-T\u4e0eTCR-T\u7684\u533a\u522b<\/span><\/strong><br  \/><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;line-height: 2;\">\u2003\u2003\u6211\u4eec\u53ef\u4ee5\u6253\u4e00\u4e2a\u7b80\u5355\u7684\u6bd4\u55bb\u3002CAR-T\u662f\u4e00\u79cd\u201c\u6362\u5934\u201d\u6280\u672f\u3002\u5b83\u628aTCR\u7684\u201c\u5934\u201d\u76f4\u63a5\u6362\u6210\u4e00\u4e2a\u7279\u5f02\u6027\u7684\u6297\u4f53\u3002\u8fd9\u6837\u5c31\u53ef\u4ee5\u8ba9T\u7ec6\u80de\u5c31\u5728\u6297\u4f53\u7684\u6307\u5f15\u4e0b\u76f4\u63a5\u653b\u51fb\u764c\u7ec6\u80de\u3002\u548cCAR-T\u8fd9\u79cd\u5927\u624b\u7b14\u7684\u6539\u52a8\u76f8\u6bd4\uff0c\u57fa\u56e0\u4fee\u6539\u7684T\u7ec6\u80de\u53d7\u4f53\u53ef\u4ee5\u8bf4\u53ea\u662f\u7b80\u5355\u5730\u201c\u7406\u4e86\u7406\u53d1\u201d\u3002<\/span><br  \/><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;line-height: 2;\">\u2003\u2003\u7528\u6765\u201c\u7406\u53d1\u201d\u7684T-\u7ec6\u80de\u5e76\u975e\u4efb\u4f55T\u7ec6\u80de\u3002\u8fd9\u7c7bT\u7ec6\u80de\u901a\u5e38\u4f1a\u201c\u4fb5\u5165\u201d\u764c\u7ec4\u7ec7\u3002\u8fd9\u8bf4\u660e\u4ed6\u4eec\u5bf9\u764c\u7ec6\u80de\u6709\u4e00\u5b9a\u7684\u8bc6\u522b\u80fd\u529b\u3002\u4e8b\u5b9e\u4e0a\uff0c\u6211\u4eec\u53ef\u4ee5\u5728\u8fd9\u7c7bT\u7ec6\u80de\u4e2d\u53d1\u73b0\u5bf9\u764c\u7ec6\u80de\u76f8\u5173\u6297\u539f\uff08Tumor Associated Antigen, TAA\uff09\u5177\u6709\u7279\u5f02\u6027\u8bc6\u522b\u80fd\u529b\u7684T\u7ec6\u80de\u3002\u8fd9\u7c7b\u6297\u539f\u5305\u62ecCEA\uff0cHer-2\uff0cCD19\uff0cgp100, MART-1, MAGA-A3, NY-ESO-1, 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TCR\uff09\u3002<\/span><br  \/><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;line-height: 2;\">\u2003\u2003\u8fd9\u6b21\u300a\u81ea\u7136-\u533b\u5b66\u300b\u6742\u5fd7\u62a5\u9053\u7684\u5c31\u662f\u7531\u7f8e\u56fd\u9a6c\u91cc\u5170\u5927\u5b66\u533b\u5b66\u9662\uff0c\u6ee8\u5dde\u5927\u5b66\u533b\u5b66\u9662\u548c\u76ee\u524d\u514d\u75ab\u6cbb\u7597\u7684\u201c\u5f53\u7ea2\u70b8\u5b50\u9e21\u201d\u4e4b\u4e00\uff1aAdaptimmune\u516c\u53f8\u8054\u5408\u7814\u53d1\u7684\u4e00\u6b3e\u201c\u57fa\u56e0\u4fee\u6539\u7684TCR\u201d\u3002\u5728\u4fee\u6539\u4e86\u51e0\u4e2a\u5173\u952e\u6c28\u57fa\u9178\u4ee5\u540e\uff0c\u8fd9\u4e9b\u57fa\u56e0\u4fee\u6539\u7684TCR\u5927\u5927\u63d0\u9ad8\u4e86\u548c\u4e00\u79cd\u5e38\u89c1\u7684\u764c\u75c7TAA\uff0cNY-ESO-1\uff0c\u7684\u4eb2\u548c\u529b\u3002\u4ece\u800c\u53ef\u4ee5\u7528\u6765\u8fdb\u653b\u6709NY-ESO-1\u8fc7\u91cf\u8868\u8fbe\u7684\u764c\u75c7\uff0c\u6bd4\u5982\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff08Multiple Myeloma\uff09\u3002 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initial;vertical-align: baseline;line-height: 2;\">\u2003\u2003<\/span><strong><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;color: rgb(229, 51, 51);line-height: 2;\">\u5f00\u53d1\u6700\u4f73\u7684CAR\u8bbe\u8ba1<\/span><\/strong><br  \/><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;line-height: 2;\">\u2003\u2003\u8fc7\u53bb\u768420\u5e74\u4e2dCAR\u7684\u8bbe\u8ba1\u5df2\u7ecf\u53d6\u5f97\u4e86\u957f\u8db3\u7684\u8fdb\u5c55\uff08\u56fe2\uff09\u30021991\u5e74\u67093\u4e2a\u5b9e\u9a8c\u5ba4\u62a5\u9053\u4e86\u7b2c\u4e00\u4ee3CAR\u7684\u8bbe\u8ba1\u3002Kuwana\u7b49\u4eba\u6700\u5148\u6784\u9020\u4e86\u5d4c\u5408\u53d7\u4f53\uff0c\u4f7fT\u7ec6\u80de\u4e0d\u4f9d\u8d56\u4e8eMHC-I\u7c7b\u5206\u5b50\u8bc6\u522b\u9776\u7ec6\u80de\u3002Roberts\u3001Finney\u548c Lawson 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 \/><\/p>\n<p><img class=\"\"     style=\"border-width: 0px;border-style: none;border-color: initial;vertical-align: middle;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2018\/12\/2-1544159911.jpeg\" alt=\"CAR-T\u4e0eTCR-T\u7684\u533a\u522b\u5728\u54ea\u91cc\uff1f\" title=\"CAR-T\u4e0eTCR-T\u7684\u533a\u522b\u5728\u54ea\u91cc\uff1f\"  \/><br  \/><\/p>\n<p><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;line-height: 2;\">\u56fe2\uff1aCAR-T\u7ec6\u80de\u7684\u8bbe\u8ba1<\/span><\/p>\n<p><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;line-height: 2;\">\u2003\u2003\u7b2c\u4e00\u4ee3CAR\u5f15\u5165\u4e86CD3\u03b6\u94fe\u6216\u7c7b\u4f3c\u7684\u4fe1\u53f7\u57df\u3002\u57fa\u4e8e\u6297\u4f53\u518d\u5b9a\u5411\u7684T\u7ec6\u80de\u9996\u5148\u7531Kuwana\u8bbe\u8ba1\u5e76\u7531Eshhar\u5b8c\u5584\u3002Roberts\u548cFinney\u9996\u5148\u8bbe\u8ba1\u4e86\u6574\u5408CD28\u6216CD137\u4fe1\u53f7\u57df\u7684\u7b2c\u4e8c\u4ee3CARs<\/span><br  \/><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;line-height: 2;\">\u2003\u2003\u4e3a\u4e86\u8fdb\u4e00\u6b65\u6539\u826fCAR\u7684\u8bbe\u8ba1\uff0c\u8bb8\u591a\u7814\u7a76\u7ec4\u5f00\u59cb\u7740\u773c\u4e8e\u53d1\u5c55\u7b2c\u4e09\u4ee3CAR\uff0c\u4e0d\u4ec5\u5305\u62ec\u201c\u4fe1\u53f71\u201d\u3001\u201c\u4fe1\u53f72\u201d\uff0c\u8fd8\u5305\u62ec\u4e86\u989d\u5916\u7684\u5171\u523a\u6fc0\u4fe1\u53f7\u3002\u4e0d\u540c\u7814\u7a76\u8005\u4eec\u7528\u4e0d\u540c\u6750\u6599\u5f00\u5c55\u7684\u7814\u7a76\u6240\u5f97\u5230\u7684\u7b2c\u4e8c\u4ee3CAR\u548c\u7b2c\u4e09\u4ee3CAR\u7684\u6bd4\u8f83\u7ed3\u679c\u662f\u77db\u76fe\u7684\u3002\u4e0d\u8fc7\uff0c\u65b0\u4e00\u4ee3CAR-T\u80fd\u6709\u6548\u63a7\u5236\u6bd2\u6027\u3002<\/span><br  \/><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;line-height: 2;\">\u2003\u2003<\/span><strong><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;color: rgb(0, 0, 0);line-height: 2;\">\u900f\u89c6ACT\u6bd2\u6027<\/span><\/strong><br  \/><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;line-height: 2;\">\u2003\u2003\u5341\u591a\u5e74\u6765\uff0c\u8bb8\u591aACT\u4e34\u5e8a\u8bd5\u9a8c\u8868\u660e\u5404\u7c7b\u5de5\u7a0b\u5316\u7684\u7ec6\u80de\u4ea7\u54c1\u76f8\u5f53\u5b89\u5168\uff0c\u4f46\u6709\u6548\u6027\u76f8\u5bf9\u7f3a\u4e4f\u3002\u8fc7\u53bb\u76844\u5e74\u91cc\uff0cACT\u7684\u7597\u6548\u53d1\u751f\u4e86\u4e00\u573a\u9769\u547d\u6027\u53d8\u5316\uff0c\u4f53\u73b0\u5728\u5de5\u7a0b\u5316\u7684T\u7ec6\u80de\u53ef\u4ee5\u5728\u4f53\u5185\u5927\u91cf\u6269\u589e\uff0c\u751a\u81f3\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u53ef\u4ee5\u6301\u7eed\u6027\u5b58\u6d3b\u3002\u8fd9\u5f7b\u5e95\u7684\u6539\u53d8\u4e86ACT\u7684\u7597\u6548\uff0c\u5c24\u5176\u4f53\u73b0\u5728CAR-T\u7ec6\u80de\u5e94\u7528\u4e8e\u764c\u75c7\u6cbb\u7597\uff0c\u4f46\u662f\u5728\u663e\u793a\u51fa\u7597\u6548\u7684\u540c\u65f6\uff0c\u4f34\u968f\u6709\u6bd2\u6027\u3002<\/span><br  \/><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;line-height: 2;\">\u2003\u2003<\/span><strong><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;color: rgb(0, 0, 0);line-height: 2;\">\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff08CRS\uff09<\/span><\/strong><br  \/><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;line-height: 2;\">\u2003\u2003CAR-T\u6cbb\u7597\u9aa8\u9ad3\u6e90\u80bf\u7624\u6700\u663e\u8457\u7684\u6bd2\u6027\u662fCRS\u3002\u9ad8\u5ea6\u589e\u6b96\u7684T\u7ec6\u80de\u80fd\u5f15\u8d77CRS\uff0c\u8868\u73b0\u4e3a\u9ad8\u70ed\u548c\u808c\u75db\uff0c\u4e0d\u7a33\u5b9a\u7684\u4f4e\u8840\u538b\u548c\u547c\u5438\u8870\u7aed\u3002\u8fd9\u662f\u4e00\u4e2a\u610f\u60f3\u4e0d\u5230\u7684\u7ed3\u679c\uff0c\u56e0\u4e3a\u5728\u4e34\u5e8a\u524d\u52a8\u7269\u6a21\u578b\u4e2d\u6ca1\u6709\u51fa\u73b0\u7c7b\u4f3c\u75c7\u72b6\u3002<\/span><br  \/><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: 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2;\">\u2003\u2003\u5e78\u8fd0\u7684\u662f\uff0c\u9488\u5bf9\u8fd9\u4e9b\u4e25\u91cd\u7684CRS\uff0c\u5bfb\u627e\u5230\u4e86\u4e00\u79cd\u6cbb\u7597\u65b9\u6cd5\uff0c\u5e94\u7528IL-6\u53d7\u4f53\u62ee\u6297\u5242tocilizumab\u6765\u963b\u65adIL-6\u7684\u4f5c\u7528\u3002\u91c7\u7528\u9ad8\u5ea6\u589e\u6b96\u7684CAR-T\u6cbb\u7597ALL\u60a3\u8005\uff0c\u786e\u8ba4\u4e86IL-6\u7684\u51fa\u73b0\u548ctocilizumab\u5bf9\u4e25\u91cdCRS\u7684\u7597\u6548\uff0c\u5e76\u4e14\u6211\u4eec\u89c2\u5bdf\u5230\u4e86\u53cc\u7279\u5f02\u6027T\u7ec6\u80de\u8854\u63a5\u6297\u4f53blinatumomab\u5f15\u8d77\u7684\u4e25\u91cdCRS\u5177\u6709\u7c7b\u4f3c\u673a\u5236\u3002<\/span><br  \/><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;line-height: 2;\">\u2003\u2003\u53e6\u4e00\u4e2a\u91cd\u8981\u53d1\u73b0\u662f\uff0c\u4e25\u91cd\u7684CRS\u51e0\u4e4e\u53d1\u751f\u5728\u9ad8\u75be\u75c5\u8d1f\u8377\u75c5\u4eba\u8eab\u4e0a\u3002\u8fd9\u610f\u5473\u7740\u5c06CAR\u5e94\u7528\u4e8e\u75be\u75c5\u65e9\u671f\u60a3\u8005\u8eab\u4e0a\uff0c\u5728\u75be\u75c5\u6076\u5316\u4e4b\u524d\u4f7f\u7528CAR-T\u6765\u6740\u706d\u80bf\u7624\uff0c\u53d1\u751f\u4e25\u91cdCRS\u98ce\u9669\u5c06\u5927\u5927\u964d\u4f4e\u3002<\/span><br  \/><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;line-height: 2;\">\u2003\u2003<\/span><strong><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;color: rgb(229, 51, 51);line-height: 2;\">\u5173\u4e8e\u9776\u5411\u6bd2\u6027<\/span><\/strong><br  \/><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;line-height: 2;\">\u2003\u2003T\u7ec6\u80de\u589e\u6b96\u53ef\u76f4\u63a5\u5bfc\u81f4CRS\u3002\u5b83\u4e0d\u4f9d\u8d56\u4e8e\u6539\u9020\u7684T\u7ec6\u80de\u7684\u6297\u539f\u7279\u5f02\u6027\uff0c\u5373\u4f7fCAR\u662f\u76f8\u540c\u7684\uff0c\u6cbb\u7597\u4e0d\u540c\u7684\u75be\u75c5\u6709\u53ef\u80fdCRS\u98ce\u9669\u548c\u75c7\u72b6\u4e5f\u4f1a\u6709\u6240\u4e0d\u540c\u3002\u4f8b\u5982\u5728\u6cbb\u7597CLL\u548c\u5f25\u6f2b\u5927B\u65f6CRS\u8f83\u8f7b\u800c\u6cbb\u7597ALL\u65f6CRS\u76f8\u5bf9\u8f83\u91cd\u3002<\/span><br  \/><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;line-height: 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initial;vertical-align: baseline;line-height: 2;\">\u2003\u2003<\/span><strong><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;line-height: 2;\">\u5176\u4ed6\u6bd2\u6027<\/span><\/strong><br  \/><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;line-height: 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baseline;line-height: 2;\">\u2003\u2003<\/span><strong><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;line-height: 2;\">\u751f\u5b58\u4e0e\u6bc1\u706d\uff1a\u81ea\u6740\u7ed3\u6784\u80fd\u5426\u51cf\u5f31\u975e\u80bf\u7624\u9776\u5411\u5f15\u8d77\u7684\u6bd2\u6027?<\/span><\/strong><br  \/><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;line-height: 2;\">\u2003\u2003\u4f7f\u7528\u6539\u9020\u7684T\u7ec6\u80de\u6700\u5927\u7684\u4e0d\u786e\u5b9a\u6027\u662f\u5229\u7528\u751f\u7269\u5408\u6210\u6280\u672f\u8bf1\u5bfc\u7684\u65b0\u7684\u3001\u589e\u5f3a\u7684\u7ec6\u80de\u6548\u5e94\u662f\u5426\u4f1a\u5f15\u53d1\u610f\u5916\u7684\u8131\u9776\u6bd2\u6027\u3002<\/span><br  \/><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;line-height: 2;\">\u2003\u2003CAR-T\u7ec6\u80de\u7684\u975e\u80bf\u7624\u9776\u5411\u6bd2\u6027\u548cTCR\u7ec6\u80de\u7684\u8131\u9776\u6bd2\u6027\u88ab\u683c\u5916\u5173\u6ce8\u3002\u6709\u591a\u79cd\u65b9\u6cd5\u53ef\u4ee5\u7f13\u89e3\u8fd9\u4e9b\u95ee\u9898\u3002\u6211\u4eec\u53d1\u73b0\u5229\u7528\u7f16\u7801CAR\u7684mRNA\u8f6c\u67d3T\u7ec6\u80de\uff0c\u9650\u5236CAR\u4ec5\u5728\u8f6c\u67d3T\u7ec6\u80de\u4e2d\u8868\u8fbe\uff0c\u5bf9\u8bc4\u4f30\u51fa\u73b0\u7684\u76f4\u63a5\u6bd2\u6027\u6709\u5e2e\u52a9\u3002\u5f53\u51fa\u73b0\u6bd2\u6027\u53cd\u5e94\uff0c\u505c\u6b62\u7ec6\u80de\u8f93\u6ce8\uff0c\u6bd2\u6027\u4f1a\u8fc5\u901f\u51cf\u5f31\u3002\u7814\u7a76\u4eba\u5458\u4e5f\u63d0\u51fa\u4e86\u8bb8\u591a\u8bf1\u5bfc\u57fa\u56e0\u4fee\u9970T\u7ec6\u80de\u51cb\u4ea1\u7684\u65b9\u6cd5\u3002\u8fd9\u4e9b\u65b9\u6cd5\u5f88\u53ef\u80fd\u90fd\u4f1a\u88ab\u6574\u5408\uff0c\u4ee5\u4fbf\u6309\u9700\u6e05\u9664T\u7ec6\u80de\uff0c\u6ee1\u8db3\u4e25\u683c\u7684\u5b89\u5168\u9700\u6c42\u3002<\/span><br  \/><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;line-height: 2;\">\u2003<\/span><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;color: rgb(229, 51, 51);line-height: 2;\">\u2003<\/span><strong><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;color: rgb(229, 51, 51);line-height: 2;\">\u7ed3 &nbsp;\u8bba<\/span><\/strong><br  \/><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;line-height: 2;\">\u2003\u2003\u57fa\u4e8e\u6b63\u5728\u8fdb\u884c\u7684\u8bd5\u9a8c\uff0c\u8868\u8fbeCARS\u548cTCRS\u7684T\u7ec6\u80de\u5df2\u7ecf\u4e3a\u5e7f\u6cdb\u7684\u5546\u4e1a\u5e94\u7528\u51c6\u5907\u5c31\u7eea\u3002\u534e\u5c14\u8857\u7684\u8d44\u6e90\u6b63\u63a8\u52a8\u8fd9\u4e2a\u66fe\u56e0\u6295\u8d44\u4e0d\u8db3\u800c\u88ab\u9650\u5236\u7684\u9886\u57df\u7684\u8fdb\u6b65\u3002\u5728\u8f93\u6ce8\u7684T\u7ec6\u80de\u4e2d\u5f15\u5165\u6216\u5220\u9664\u57fa\u56e0\uff0c\u63d0\u4f9b\u4e86\u80fd\u514b\u670d\u80bf\u7624\u514d\u75ab\u6291\u5236\u5fae\u73af\u5883\u7684\u65b0\u7ec6\u80de\u5236\u54c1\uff0c\u5e76\u4e14\u6700\u540e\u53ef\u80fd\u4e0d\u9700\u8981\u4f7f\u7528\u514d\u75ab\u68c0\u67e5\u70b9\u5c01\u95ed\u6297\u4f53\u3002ACT\u5148\u8fdb\u7684\u57fa\u56e0\u5de5\u7a0b\u6280\u672f\u7684\u5230\u6765\uff0c\u5c06\u4f1a\u4f7f\u5229\u7528\u5408\u6210\u751f\u7269\u5b66\u539f\u7406\u8fdb\u884c\u764c\u75c7\u3001\u6162\u6027\u611f\u67d3\u548c\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u6cbb\u7597\u53d6\u5f97\u663e\u8457\u8fdb\u5c55\u3002<\/span><\/p>\n<p><span style=\"border-width: 0px;border-style: initial;border-color: initial;vertical-align: baseline;line-height: 2;\"><br  \/><\/span><\/p>\n<p style=\"margin-bottom: 20px;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;line-height: 2em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;widows: 1;font-family: \u5fae\u8f6f\u96c5\u9ed1;font-style: italic;text-indent: 32px;color: rgb(102, 102, 102);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6587<\/span><span style=\"max-width: 100%;font-size: 14px;widows: 1;font-family: \u5fae\u8f6f\u96c5\u9ed1;font-style: italic;text-indent: 32px;color: rgb(102, 102, 102);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7ae0\u4fe1\u606f\u6e90\u4e8e<\/span><span style=\"max-width: 100%;font-size: 14px;widows: 1;font-family: \u5fae\u8f6f\u96c5\u9ed1;font-style: italic;text-indent: 32px;color: rgb(102, 102, 102);box-sizing: 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!important;overflow-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;display: inline-block;vertical-align: top;width: 133.438px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 18px;margin-bottom: 8px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box;border-top: 1px dotted rgb(223, 223, 223);overflow-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section  style=\"max-width: 100%;display: inline-block;vertical-align: top;width: 50.0312px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 100%;line-height: 0.8;box-sizing: border-box !important;overflow-wrap: break-word 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