{"id":73820,"date":"2018-11-18T01:00:00","date_gmt":"2018-12-07T05:19:49","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/12\/07\/47a2c5ba02\/"},"modified":"2018-12-07T13:20:12","modified_gmt":"2018-12-07T05:20:12","slug":"47a2c5ba02","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/73820\/","title":{"rendered":"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a"},"content":{"rendered":"
\n

\u70b9\u51fb\u4e0a\u65b9\u7684  <\/span>\u25b2 \u6dfb\u52a0\u5173\u6ce8<\/span><\/p>\n

1. <\/span>\u5168\u7403\u5e02\u573a\u53d1\u5c55\u8fc5\u901f<\/span><\/p>\n

1.1 <\/span>\u91cd\u78c5\u4ea7\u54c1\u6301\u7eed\u589e\u957f\uff0c\u7a33\u5c45\u7545\u9500\u699c\u524d\u5217<\/o:p><\/span><\/span><\/p>\n

\u5355\u6297\u836f\u7269\u51ed\u501f\u5176\u9ad8\u9776\u5411\u6027\u53ef\u76f4\u8fbe\u75c5\u53d8\u7ec6\u80de\uff0c\u5177\u6709\u51cf\u5c11\u6b63\u5e38\u7ec6\u80de\u53d7\u635f\u3001\u51cf\u5c11\u526f\u4f5c\u7528\u7684\u72ec\u7279\u4f18\u52bf\uff0c\u5e7f\u6cdb\u5e94\u7528\u4e8e\u4e34\u5e8a\u3002\u5355\u6297\u836f\u7269\u5728\u5168\u7403\u751f\u7269\u5236\u836f\u4e2d\u6240\u5360\u5e02\u573a\u4efd\u989d\u4ece<\/span>2000 <\/span>\u5e74\u7684<\/span>10 %<\/span>\u589e\u957f\u81f3\u5f53\u524d\u7684\u7ea6<\/span>50%<\/span>\uff0c\u662f\u73b0\u4ee3\u751f\u7269\u5236\u836f\u884c\u4e1a\u4e2d\u5360\u6bd4\u6700\u5927\u3001\u589e\u957f\u6700\u5feb\u7684\u7ec6\u5206\u5b50\u884c\u4e1a\u3002\u622a\u81f3<\/span>2017<\/span>\u5e74\u5e95\uff0c<\/span>FDA <\/span>\u5408\u8ba1\u6279\u51c6\u4e0a\u5e02\u9500\u552e\u7684\u5355\u6297\u836f\u7269\u8fbe<\/span>77 <\/span>\u4e2a\uff0c<\/span>2017 <\/span>\u5e74\u9500\u552e\u989d\u5408\u8ba1<\/span>1061 <\/span>\u4ebf\u7f8e\u5143\uff0c\u8f83<\/span>2016 <\/span>\u5e74\u4e0a\u5347\u8d85\u8fc7<\/span>20%<\/span>\u3002<\/span><\/span><\/p>\n

\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"<\/o:p><\/span><\/span><\/p>\n

2017 <\/span>\u5e74\uff0c\u5355\u6297\u836f\u7269\u5728\u5168\u7403\u5341\u5927\u7545\u9500\u836f\u54c1\u6392\u884c\u699c\u4e0a\u5360\u636e<\/span>7 <\/span>\u4e2a\u5e2d\u4f4d\uff0c<\/span>7 <\/span>\u4e2a\u4ea7\u54c1\u9500\u552e\u989d\u5408\u8ba1\u9ad8\u8fbe<\/span>656 <\/span>\u4ebf\u7f8e\u5143\u3002\u5176\u4e2d\uff0c\u963f\u8fbe\u6728\u5355\u6297\u4ee5<\/span>189 <\/span>\u4ebf\u7f8e\u5143\u9500\u552e\u989d\u9065\u9065\u9886\u5148\uff0c\u8fde\u7eed\u7b2c<\/span>6 <\/span>\u5e74\u7a33\u5c45\u5168\u7403\u7545\u9500\u836f\u699c\u9996\u3002\u5176\u4ed6\u4e0a\u699c\u7684\u5355\u6297\u836f\u7269\u5305\u62ec\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u7528\u836f\u4f9d\u90a3\u897f\u666e\u3001\u82f1\u592b\u5229\u6614\u5355\u6297\uff0c\u6297\u80bf\u7624\u7528\u836f\u5229\u59a5\u6614\u5355\u6297\u3001\u66f2\u59a5\u73e0\u5355\u6297\u548c\u8d1d\u4f10\u73e0\u5355\u6297\uff0c\u4ee5\u53ca\u773c\u5e95\u75be\u75c5\u7528\u836f\u963f\u67cf\u897f\u666e\uff0c\u9500\u552e\u989d\u5747\u8d85\u8fc7<\/span>70 <\/span>\u4ebf\u7f8e\u5143\u3002<\/span><\/span><\/p>\n

\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"<\/o:p><\/span><\/span><\/p>\n

1.2 <\/span>\u6f5c\u529b\u65b0\u54c1\u589e\u957f\u8fc5\u901f\uff0c\u9002\u5e94\u75c7\u5e7f\u6cdb<\/o:p><\/span><\/span><\/p>\n

\u8fd1\u5e74\u6765\uff0c\u65b0\u83b7\u6279\u7684\u5355\u6297\u6570\u91cf\u5448\u73b0\u7206\u53d1\u5f0f\u589e\u957f\uff0c\u7279\u522b\u662f\u5728<\/span>2017 <\/span>\u5e74\u5171\u6709<\/span>15 <\/span>\u4e2a\u4ea7\u54c1\u83b7<\/span>FDA <\/span>\u6279\u51c6\u4e0a\u5e02\uff0c\u8fbe\u5230\u5386\u53f2\u65b0\u9ad8\u3002\u65b0\u4ea7\u54c1\u4e2d\u4e0d\u4e4f\u8868\u73b0\u4f18\u5f02\u7684\u836f\u7269\uff0c\u5176\u4e2d\uff0c\u963f\u67cf\u897f\u666e\uff08<\/span>Eylea<\/span>\uff09\u548c\u7eb3\u6b66\u5355\u6297\uff08<\/span>Opdivo<\/span>\uff09\u5206\u522b\u4e8e<\/span>2011 <\/span>\u5e74\u548c<\/span>2014 <\/span>\u5e74\u5e95\u4e0a\u5e02\u540e\u653e\u91cf\u8fc5\u901f\u3002\u963f\u67cf\u897f\u666e\u662f\u62dc\u5c14\u7684\u773c\u79d1\u836f\u7269\uff0c\u6700\u521d\u4e8e<\/span>2011 <\/span>\u5e74\u83b7\u5f97<\/span>FDA <\/span>\u6279\u51c6\u6cbb\u7597\u6e7f\u6027\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\uff08<\/span>wAMD<\/span>\uff09\u4e0a\u5e02\uff0c\u5546\u54c1\u540d\u4e3a<\/span>Eylea<\/span>\u3002<\/span>2012 <\/span>\u5e74\u3001<\/span>2014 <\/span>\u5e74\u548c<\/span>2015 <\/span>\u5e74\uff0c<\/span>Eylea <\/span>\u76f8\u7ee7\u83b7\u6279<\/span>3 <\/span>\u4e2a\u65b0\u9002\u5e94\u75c7\uff1a\u89c6\u7f51\u819c\u9759\u8109\u963b\u585e\u7ee7\u53d1\u6027\u9ec4\u6591\u6c34\u80bf\uff08<\/span>RVO-ME<\/span>\uff09\u3001\u7cd6\u5c3f\u75c5\u6027\u9ec4\u6591\u6c34\u80bf\uff08<\/span>DME<\/span>\uff09\u548c\u7cd6\u5c3f\u75c5\u6027\u9ec4\u6591\u6c34\u80bf\u60a3\u8005\u7684\u7cd6\u5c3f\u75c5\u89c6\u7f51\u819c\u75c5\u53d8\uff08<\/span>DR<\/span>\uff09\u3002<\/span>Eylea <\/span>\u4ee5\u8001\u5e74\u4eba\u5e02\u573a\u4e3a\u57fa\u7840\uff0c\u5411\u7cd6\u5c3f\u75c5\u4eba\u7fa4\u5f00\u62d3\uff0c\u81ea\u4e0a\u5e02\u4ee5\u6765\uff0c\u5728\u7f8e\u56fd\u3001\u6b27\u6d32\u548c\u65e5\u672c\u5e02\u573a\u589e\u957f\u5341\u5206\u8fc5\u901f\uff0c\u5e74\u5747\u590d\u5408\u589e\u957f\u7387\u5206\u522b\u8fbe\u5230<\/span>41%<\/span>\u3001<\/span>70%<\/span>\u548c<\/span>94%<\/span>\u3002<\/span>2017 <\/span>\u5e74\u5168\u7403\u9500\u552e\u989d\u8fbe<\/span>82.60 <\/span>\u4ebf\u7f8e\u5143\uff0c\u540c\u6bd4\u589e\u957f<\/span>15%<\/span>\uff0c\u6392\u5728\u5168\u7403\u7545\u9500\u836f\u7269\u6392\u884c\u699c\u7b2c<\/span>3 <\/span>\u4f4d\u3002<\/o:p><\/span><\/span><\/p>\n

\u7eb3\u6b66\u5355\u6297\u4ee5<\/span>PD-1 <\/span>\u4e3a\u9776\u70b9\uff0c\u901a\u8fc7\u6fc0\u6d3b\u88ab\u6291\u5236\u7684\u514d\u75ab\u7cfb\u7edf\u6765\u653b\u51fb\u80bf\u7624\u7ec6\u80de\uff0c\u5177\u6709\u5e7f\u6cdb\u7684\u6297\u80bf\u7624\u9002\u5e94\u75c7\uff0c<\/span>PD-1 <\/span>\u76f8\u5173\u7684\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u4e5f\u8363\u81ba<\/span>2018 <\/span>\u5e74\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66<\/span>\/<\/span>\u533b\u5b66\u5956\u3002<\/span>Opdivo <\/span>\u81ea<\/span>2014<\/span>\u5e74\u5e95\u4e0a\u5e02\u4ee5\u6765\uff0c\u9646\u7eed\u5728<\/span>FDA <\/span>\u83b7\u6279\u4e86<\/span>9 <\/span>\u4e2a\u80bf\u7624\u9002\u5e94\u75c7\uff0c\u5305\u62ec\u9ed1\u8272\u7d20\u7624\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u80be\u7ec6\u80de\u764c\u3001\u6210\u4eba\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u3001\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u3001\u5c3f\u8def\u4e0a\u76ae\u764c\u3001\u76f4\u80a0\u764c\u3001\u80c3\u764c\u548c\u809d\u764c\u3002<\/span>2017 <\/span>\u5e74\u9500\u552e\u989d\u8fbe<\/span>58.15 <\/span>\u4ebf\u7f8e\u5143\uff0c\u540c\u6bd4\u589e\u957f<\/span>23%<\/span>\uff0c\u6392\u5728\u5168\u7403\u7545\u9500\u836f\u7269\u6392\u884c\u699c\u7b2c<\/span>11 <\/span>\u4f4d\u3002\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"<\/o:p><\/span><\/span><\/p>\n

1.3 <\/span>\u5168\u7403\u751f\u7269\u7c7b\u4f3c\u836f\u5d2d\u9732\u5934\u89d2\uff0c\u524d\u666f\u5e7f\u9614<\/o:p><\/span><\/span><\/p>\n

2012-2019 <\/span>\u5e74\uff0c<\/span>6 <\/span>\u4e2a\u91cd\u78c5\u5355\u6297\u4e13\u5229\u76f8\u7ee7\u5230\u671f\uff0c\u4e3a\u751f\u7269\u7c7b\u4f3c\u836f\u6253\u5f00\u673a\u4f1a\u5927\u95e8\u3002<\/span>\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\u5728\u4e2d\u56fd\u3001\u5370\u5ea6\u3001\u97e9\u56fd\u3001\u4fc4\u7f57\u65af\u7b49\u975e\u89c4\u8303\u5e02\u573a\u8f83\u65e9\u83b7\u6279\uff0c\u4f46\u76f4\u5230<\/span>2013 <\/span>\u5e74<\/span>9 <\/span>\u6708\uff0c\u6b27\u6d32\u624d\u9996\u6b21\u6279\u51c6\u4e86\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff08\u82f1\u592b\u5229\u6614\u5355\u6297\uff09\uff0c\u622a\u81f3<\/span>2018 <\/span>\u5e74<\/span>10 <\/span>\u6708\uff0c\u6b27\u6d32\u5171\u6279\u51c6\u4e86<\/span>21 <\/span>\u4e2a\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\u3002\u76f8\u6bd4\u6b27\u6d32\uff0c\u7f8e\u56fd<\/span>FDA <\/span>\u5bf9\u751f\u7269\u7c7b\u4f3c\u836f\u5219\u663e\u66f4\u4e3a\u8c28\u614e\uff0c\u76f4\u5230<\/span>2016 <\/span>\u5e74\u624d\u6279\u51c6\u9996\u4e2a\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff08\u82f1\u592b\u5229\u6614\u5355\u6297\uff09\u3002\u622a\u81f3<\/span>2018 <\/span>\u5e74<\/span>10 <\/span>\u6708\uff0c<\/span>FDA <\/span>\u5171\u6279\u51c6\u4e86<\/span>7 <\/span>\u4e2a\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\u3002\u76ee\u524d\u5728\u6b27\u7f8e\u89c4\u8303\u5e02\u573a\u83b7\u6279\u7684\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\u90fd\u96c6\u4e2d\u5728\u9500\u552e\u989d\u6392\u5728\u524d\u5217\u3001\u4e13\u5229\u5df2\u8fc7\u671f\u7684<\/span>6 <\/span>\u4e2a\u91cd\u78c5\u54c1\u79cd\u3002\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"<\/o:p><\/span><\/span><\/p>\n

\u751f\u7269\u7c7b\u4f3c\u836f\u7684\u4e0a\u5e02\u6b63\u8fc5\u901f\u62a2\u5360\u539f\u7814\u836f\u7684\u5e02\u573a\u4efd\u989d\u3002<\/span>Remsima <\/span>\u662f\u82f1\u592b\u5229\u6614\u5355\u6297\u539f\u7814\u836f<\/span>Remicade <\/span>\u7684\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u4e5f\u662f\u9996\u4e2a\u5728\u6b27\u6d32\u5e02\u573a\u4e0a\u83b7\u6279\u7684\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\u3002\u81ea<\/span>2013<\/span>\u5e74\u5728\u6b27\u6d32\u4e0a\u5e02\u4ee5\u6765\uff0c\u539f\u7814\u5382\u5bb6<\/span>Merck <\/span>\u5728\u6b27\u6d32\u5e02\u573a\u7684\u9500\u552e\u989d\u5728<\/span>2015-2017 <\/span>\u5e74\u5448\u73b0\u4e0b\u6ed1\u8d8b\u52bf\u3002\u53cd\u89c2\u82f1\u592b\u5229\u6614\u5355\u6297\u7c7b\u4f3c\u836f<\/span>Remsina<\/span>\uff0c<\/span>2017 <\/span>\u5e74\u9500\u552e\u989d\u8fbe<\/span>4.19 <\/span>\u4ebf\u7f8e\u5143\uff0c\u540c\u6bd4\u589e\u957f<\/span>118%<\/span>\uff0c\u5e02\u573a\u4efd\u989d\u4e5f\u4ece<\/span>2016 <\/span>\u5e74\u7684<\/span>13%<\/span>\u589e\u957f\u5230<\/span>33%<\/span>\u3002<\/o:p><\/span><\/span><\/p>\n

\u5728\u975e\u89c4\u8303\u5e02\u573a\uff0c\u751f\u7269\u7c7b\u4f3c\u836f\u7ed9\u539f\u7814\u836f\u5e26\u6765\u7684\u51b2\u51fb\u66f4\u751a\uff0c\u5982\u5f53\u4fc4\u7f57\u65af\u672c\u571f\u4f01\u4e1a<\/span>Biocad <\/span>\u7814\u53d1\u7684\u5229\u59a5\u6614\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\u4e8e<\/span>2014 <\/span>\u5e74<\/span>4 <\/span>\u6708\u5728\u4fc4\u4e0a\u5e02\u540e\uff0c\u539f\u7814\u836f<\/span>Rituxan <\/span>\u5728\u4fc4\u9500\u552e\u989d\u5f53\u5e74\u5373\u8fc5\u901f\u4e0b\u6ed1<\/span>70%<\/span>\uff0c\u6b21\u5e74\u7ee7\u7eed\u4e0b\u6ed1<\/span>47%<\/span>\u3002\u751f\u7269\u7c7b\u4f3c\u836f\u51ed\u501f\u5176\u76f8\u4f3c\u7684\u8d28\u91cf\u548c\u7597\u6548\uff0c\u4ee5\u53ca\u4f18\u60e0\u7684\u4ef7\u683c\uff0c\u6709\u671b\u8fc5\u901f\u62a2\u5360\u539f\u7814\u836f\u7684\u5e02\u573a\u4efd\u989d\u3002<\/span><\/span><\/p>\n

\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"<\/o:p><\/span><\/span><\/p>\n

\u751f\u7269\u7c7b\u4f3c\u836f\u4f7f\u836f\u4f01\u3001\u653f\u5e9c\u3001\u60a3\u8005\u5171\u8d62\uff0c\u5168\u7403\u5e02\u573a\u9884\u8ba1\u5728<\/span>3 <\/span>\u5e74\u5185\u7a81\u7834<\/span>230 <\/span>\u4ebf\u7f8e\u5143\u3002<\/span>\u82f1\u592b\u5229\u6614\u5355\u6297<\/span>Remsima <\/span>\u5728\u6b27\u6d32\u4e0a\u5e02<\/span>4 <\/span>\u5e74\u65f6\u95f4\uff0c\u6574\u4f53\u5e02\u573a\u4efd\u989d\u5df2\u8fbe\u5230<\/span>33%<\/span>\uff0c\u5728\u4e2a\u522b\u56fd\u5bb6\u5982\u632a\u5a01\u3001\u745e\u5178\u7684\u5e02\u573a\u4efd\u989d\u5df2\u8d85\u8fc7<\/span>80%<\/span>\u3002\u636e\u7edf\u8ba1\uff0c<\/span>2015 <\/span>\u5e74\uff0c\u5fb7\u56fd\u3001\u82f1\u56fd\u3001\u610f\u5927\u5229\u3001\u8377\u5170\u3001\u6bd4\u5229\u65f6<\/span>5<\/span>\u4e2a\u56fd\u5bb6\u56e0\u4f7f\u7528<\/span>Remsima <\/span>\u66ff\u4ee3\u539f\u7814\u4ea7\u54c1\uff0c\u5171\u4e3a\u653f\u5e9c\u8282\u7ea6\u533b\u7597\u8d39\u7528<\/span>7736.7 <\/span>\u4e07\u6b27\u5143\u3002\u6709<\/span>7561<\/span>\u540d\u672c\u65e0\u7ecf\u6d4e\u80fd\u529b\u8d1f\u62c5\u9ad8\u4ef7\u539f\u7814\u836f\u7684\u60a3\u8005\u73b0\u53ef\u4ee5\u63a5\u53d7\u76f8\u5bf9\u4fbf\u5b9c\u7684\u751f\u7269\u7c7b\u4f3c\u836f\u6cbb\u7597\u3002\u751f\u7269\u7c7b\u4f3c\u836f\u53d7\u5230\u5404\u56fd\u653f\u5e9c\u7684\u652f\u6301\uff0c\u836f\u4f01\u7814\u7a76\u70ed\u60c5\u9ad8\u6da8\uff0c\u5168\u7403\u751f\u7269\u7c7b\u4f3c\u836f\u5e02\u573a\u9884\u8ba1\u5728<\/span>3 <\/span>\u5e74\u5185\u7a81\u7834<\/span>300 <\/span>\u4ebf\u7f8e\u5143\u3002\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"<\/o:p><\/span><\/span><\/p>\n

1.4 <\/span>\u56fd\u5185\u6297\u4f53\u836f\u7269\u89c4\u6a21\u8f83\u5c0f\uff0c\u8865\u9f50\u9700\u6c42<\/o:p><\/span><\/span><\/p>\n

\u76f8\u6bd4\u5168\u7403\u5e02\u573a\uff0c\u56fd\u5185\u5355\u6297\u836f\u7269\u89c4\u6a21\u5c1a\u5c0f\uff0c\u9884\u8ba1\u7ea6\u5360\u5168\u7403\u5355\u6297\u603b\u5e02\u573a\u7684<\/span>1%<\/span>\uff0c\u6e17\u900f\u7387\u6781\u4f4e\u3002\u7a76\u5176\u539f\u56e0\uff0c\u4e3b\u8981\u6709<\/span>2 <\/span>\u4e2a\uff1a<\/o:p><\/span><\/span><\/p>\n

\u00fc <\/span>\u83b7\u6279\u7684\u4ea7\u54c1\u6570\u91cf\u548c\u79cd\u7c7b\u5c11\uff1a<\/span>\u76f8\u6bd4\u56fd\u5916\u6570\u91cf\u4f17\u591a\u7684\u5355\u6297\u4ea7\u54c1\uff0c\u5728\u6211\u56fd\u83b7\u6279\u8fdb\u53e3\u4ee5\u53ca\u56fd\u4ea7\u54c1\u79cd\u6570\u91cf\u5f88\u5c11\u3002<\/span>2017 <\/span>\u5e74\u524d\uff0c\u8fdb\u53e3\u54c1\u79cd\u4ec5\u6709<\/span>10 <\/span>\u4e2a\uff0c\u56fd\u4ea7\u54c1\u79cd\u867d\u7136\u4e5f\u6709<\/span>10 <\/span>\u4e2a\uff0c\u4f46\u5176\u4e2d<\/span>4 <\/span>\u4e2a\u9f20\u6e90\u5355\u6297<\/span>\/<\/span>\u4eba\u9f20\u5d4c\u5408\u5355\u6297\u5df2\u65e0\u9500\u552e\uff0c\u771f\u6b63\u5f62\u6210\u89c4\u6a21\u5316\u9500\u552e\u7684\u56fd\u4ea7\u5355\u6297\u4ec5\u6709<\/span>3 <\/span>\u4e2a\u3002<\/span>2017 <\/span>\u5e74\u5f00\u59cb\uff0c\u56fd\u5bb6\u52a0\u901f\u5ba1\u6279\u8fdb\u53e3\u836f\u7269\uff0c\u4e0d\u8db3<\/span>2 <\/span>\u5e74\u65f6\u95f4\u5df2\u6709<\/span>9 <\/span>\u4e2a\u5355\u6297\u4ea7\u54c1\u83b7\u6279\u4e0a\u5e02\uff0c\u6781\u5927\u7684\u63d0\u9ad8\u4e86\u836f\u7269\u7684\u53ef\u53ca\u6027\u3002\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"<\/o:p><\/span><\/span><\/p>\n

\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"<\/span><\/o:p><\/span><\/p>\n

\u00fc <\/span>\u533b\u4fdd\u9650\u5236\uff0c\u4ef7\u683c\u6602\u8d35\uff1a<\/span>2009 <\/span>\u5e74\u4e4b\u524d\uff0c\u5355\u6297\u836f\u7269\u90fd\u662f\u60a3\u8005\u81ea\u8d39\uff0c<\/span>2009 <\/span>\u5e74\u540e\u4e5f\u4ec5\u6709<\/span>5 <\/span>\u4e2a\u4ea7\u54c1\u76f8\u7ee7\u8fdb\u5165\u90e8\u5206\u7701\u533b\u4fdd\u76ee\u5f55\uff0c\u5927\u90e8\u5206\u4ea7\u54c1\u5728\u7edd\u5927\u90e8\u5206\u5730\u533a\u90fd\u65e0\u533b\u4fdd\u8986\u76d6\uff0c\u9ad8\u6602\u7684\u4ef7\u683c\u9650\u5236\u4e86\u5355\u6297\u7684\u4e34\u5e8a\u63a8\u5e7f\u548c\u4f7f\u7528\u3002<\/span><\/span><\/p>\n

\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"<\/o:p><\/span><\/span><\/p>\n

\u4ee5\u5168\u7403\u7545\u9500\u7684\u4e09\u5927\u91cd\u78c5\u6297\u80bf\u7624\u5355\u6297\u836f\u7269\u4e3a\u4f8b\uff0c\u5bf9\u6bd4\u4e2d\u56fd\u7684\u9500\u552e\u4e0e\u5168\u7403\u5e02\u573a\u7684\u5dee\u8ddd\u3002\u5229\u59a5\u6614\u5355\u6297\u3001\u66f2\u59a5\u73e0\u5355\u6297\u3001\u8d1d\u4f10\u73e0\u5355\u6297\u90fd\u662f\u5236\u836f\u5de8\u5934\u7f57\u6c0f\u7684\u91cd\u78c5\u6297\u80bf\u7624\u4ea7\u54c1\uff0c\u5206\u522b\u7528\u4e8e\u6cbb\u7597\u8840\u6db2\u80bf\u7624\u3001\u4e73\u817a\u764c\u548c\u7ed3\u76f4\u80a0\u764c\u7b49\u5b9e\u4f53\u80bf\u7624\u3002\u81ea\u4e0a\u5e02\u4ee5\u6765\u9500\u552e\u989d\u9010\u5e74\u6500\u5347\uff0c<\/span>2017 <\/span>\u5e74\u5168\u7403\u9500\u552e\u989d\u5206\u522b\u4e3a<\/span>78<\/span>\u3001<\/span>74<\/span>\u3001<\/span>71 <\/span>\u4ebf\u7f8e\u5143\uff0c\u4f4d\u4e8e\u5168\u7403\u7545\u9500\u836f\u6392\u884c\u699c\u7b2c<\/span>5<\/span>\u3001<\/span>7<\/span>\u3001<\/span>9 <\/span>\u4f4d\uff0c\u4f4d\u4e8e\u5168\u7403\u7545\u9500\u6297\u80bf\u7624\u836f\u6392\u884c\u699c\u7684\u7b2c<\/span>2<\/span>\u3001<\/span>3<\/span>\u3001<\/span>4 <\/span>\u4f4d\u3002\u6839\u636e<\/span>PDB <\/span>\u6570\u636e\u5e93\uff0c<\/span>2017 <\/span>\u5e74\uff0c\u5229\u59a5\u6614\u5355\u6297\u3001\u66f2\u59a5\u73e0\u5355\u6297\u3001\u8d1d\u4f10\u73e0\u5355\u6297\u5728\u6211\u56fd\u6837\u672c\u533b\u9662\u9500\u552e\u989d\u5206\u522b\u4e3a<\/span>10.57<\/span>\u3001<\/span>8.87<\/span>\u3001<\/span>5.73 <\/span>\u4ebf\u5143\u4eba\u6c11\u5e01\uff0c\u8fdc\u4f4e\u4e8e\u5168\u7403\u5e02\u573a\uff0c\u8003\u8651\u5230\u6076\u6027\u80bf\u7624\u5728\u4e2d\u56fd\u7684\u53d1\u75c5\u7387\uff0c\u76f8\u5173\u836f\u7269\u7684\u589e\u957f\u7a7a\u95f4\u5e7f\u9614\u3002<\/span><\/span><\/p>\n

\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"<\/o:p><\/span><\/span><\/p>\n

2. <\/span>\u533b\u4fdd\u76ee\u5f55\u64ac\u52a8\u56fd\u5185\u5e02\u573a\uff0c\u9700\u6c42\u91ca\u653e<\/o:p><\/span><\/span><\/p>\n

2.1 <\/span>\u65b0\u7248\u533b\u4fdd\u76ee\u5f55\u7eb3\u5165\u591a\u4e2a\u5355\u6297\uff0c\u5feb\u901f\u653e\u91cf<\/o:p><\/span><\/span><\/p>\n

n <\/span>17 <\/span>\u5e74<\/span>2 <\/span>\u6708\u56fd\u5bb6\u65b0\u7248\u533b\u4fdd\u76ee\u5f55\u9996\u6b21\u7eb3\u5165<\/span>2 <\/span>\u4e2a\u5355\u6297\u54c1\u79cd\uff1a<\/o:p><\/span><\/span><\/p>\n

\u00fc <\/span>\u5355\u6297\u836f\u7269\u5353\u8d8a\u7684\u7597\u6548\u7ecf\u56fd\u5916\u591a\u5e74\u4e34\u5e8a\u68c0\u9a8c\u83b7\u5f97\u666e\u904d\u8ba4\u53ef\uff0c\u56fd\u5185\u4e13\u5bb6\u4e5f\u591a\u6b21\u63d0\u8bae\u5e94\u628a\u5355\u6297\u836f\u7269\u7eb3\u5165\u533b\u4fdd\u62a5\u9500\u8303\u56f4\u3002\u4eba\u793e\u90e8\u63a5\u7eb3\u5efa\u8bae\uff0c\u4e8e<\/span>2017 <\/span>\u5e74<\/span>2 <\/span>\u6708<\/span>24 <\/span>\u65e5\u516c\u5e03\u4e86\u65b0\u7248\u533b\u4fdd\u76ee\u5f55\uff0c\u9996\u6b21\u5c06<\/span>2 <\/span>\u4e2a\u5355\u6297\u836f\u7269\u7eb3\u5165\u76ee\u5f55\uff0c\u5206\u522b\u662f\u91cd\u7ec4\u4eba<\/span>II <\/span>\u578b\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u53d7\u4f53<\/span>–<\/span>\u6297\u4f53\u878d\u5408\u86cb\u767d\u548c\u5df4\u5229\u6614\u5355\u6297\u3002<\/o:p><\/span><\/span><\/p>\n

\u00fc <\/span>\u91cd\u7ec4\u4eba<\/span>II <\/span>\u578b\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\u53d7\u4f53<\/span>–<\/span>\u6297\u4f53\u878d\u5408\u86cb\u767d\u53c8\u540d\u4f9d\u90a3\u897f\u666e\uff0c\u7528\u4e8e\u6cbb\u7597\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u3001\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u3001\u94f6\u5c51\u75c5\u7b49\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3002\u56fd\u5185\u4e0a\u5e02\u7684\u4ea7\u54c1\u9664\u4e86\u539f\u7814\u836f\u6069\u5229\uff0c\u8fd8\u6709<\/span>3 <\/span>\u4e2a\u56fd\u4ea7\u54c1\u79cd\u3002\u5df4\u5229\u6614\u5355\u6297\u7528\u4e8e\u6cbb\u7597\u80be\u79fb\u690d\u6392\u65a5\u53cd\u5e94\uff0c\u76ee\u524d\u56fd\u5185\u4ec5\u6709\u8bfa\u534e\u7684\u539f\u7814\u836f\u8212\u83b1\u5728\u552e\u3002<\/o:p><\/span><\/span><\/p>\n

n <\/span>8 <\/span>\u4e2a\u5355\u6297\u88ab\u7eb3\u5165<\/span>17 <\/span>\u5e74\u533b\u4fdd\u8c08\u5224\u76ee\u5f55\uff0c<\/span>6 <\/span>\u4e2a\u4ea7\u54c1\u8c08\u5224\u6210\u529f\uff1a<\/o:p><\/span><\/span><\/p>\n

\u00fc <\/span>\u9488\u5bf9\u5355\u6297\u6cbb\u7597\u6548\u679c\u663e\u8457\u4f46\u4ef7\u683c\u6602\u8d35\u7684\u73b0\u72b6\uff0c\u4eba\u793e\u90e8\u5728<\/span>2017 <\/span>\u5e74<\/span>4 <\/span>\u6708<\/span>14 <\/span>\u65e5\u53d1\u5e03\u7684\u300a\u5173\u4e8e\u786e\u5b9a<\/span>2017 <\/span>\u5e74\u56fd\u5bb6\u57fa\u672c\u533b\u7597\u4fdd\u9669\u3001\u5de5\u4f24\u4fdd\u9669\u548c\u751f\u80b2\u4fdd\u9669\u836f\u54c1\u76ee\u5f55\u8c08\u5224\u8303\u56f4\u7684\u901a\u544a\u300b\u4e2d\uff0c\u5c06<\/span>8 <\/span>\u4e2a\u5355\u6297\u4ea7\u54c1\u7eb3\u5165\u8c08\u5224\u836f\u7269\u76ee\u5f55\uff08\u5171<\/span>44 <\/span>\u4e2a\uff09\uff0c\u5176\u4e2d\u6709<\/span>5 <\/span>\u4e2a\u4e3a\u6297\u80bf\u7624\u7528\u836f\uff0c<\/span>2 <\/span>\u4e2a\u4e3a\u6cbb\u7597\u6e7f\u6027\u8001\u5e74\u6027\u9ec4\u6591\u53d8\u6027\u7528\u836f\uff0c<\/span>1 <\/span>\u4e2a\u6cbb\u7597\u514b\u7f57\u6069\u75c5\uff08\u81ea\u8eab\u514d\u75ab\u75c5\u7684\u4e00\u79cd\uff09\u3002<\/o:p><\/span><\/span><\/p>\n

\u00fc <\/span>7 <\/span>\u6708<\/span>19 <\/span>\u65e5\uff0c\u4eba\u793e\u90e8\u516c\u5e03\u8c08\u5224\u7ed3\u679c\uff0c\u6709<\/span>6 <\/span>\u4e2a\u5355\u6297\u836f\u7269\u8c08\u5224\u6210\u529f\u88ab\u7eb3\u5165\u533b\u4fdd\u76ee\u5f55\uff0c\u8fdb\u53e3\u54c1\u79cd\u6709\u7f57\u6c0f\u4e09\u5927\u6297\u80bf\u7624\u5355\u6297\u548c\u96f7\u73e0\u5355\u6297\uff0c\u56fd\u4ea7\u54c1\u4e2d\u6709\u5eb7\u67cf\u897f\u666e\u548c\u6cf0\u6b23\u751f\u3002\u8c08\u5224\u6210\u529f\u4ea7\u54c1\u5e73\u5747\u964d\u5e45\u4e3a<\/span>40%<\/span>\uff0c\u5176\u4e2d\u66f2\u59a5\u73e0\u5355\u6297\u964d\u5e45\u6700\u5927\u8fbe<\/span>66%<\/span>\uff0c\u6309\u7167\u6bcf\u4e2a\u7597\u7a0b<\/span>14-16 <\/span>\u9488\u6765\u8ba1\u7b97\uff0c\u5728\u964d\u4ef7\u8fdb\u533b\u4fdd\u524d\uff0c\u60a3\u8005\u5168\u90e8\u81ea\u8d39\u8d39\u7528\u7ea6\u4e3a<\/span>32-36 <\/span>\u4e07\u5143\uff0c\u964d\u4ef7\u540e\u6309\u7167\u81ea\u8d39<\/span>20%<\/span>\u6765\u8ba1\u7b97\uff0c\u60a3\u8005\u81ea\u8d39\u8d39\u7528\u4ec5\u4e0d\u5230<\/span>2.5 <\/span>\u4e07\u5143\uff0c\u6781\u5927\u7684\u51cf\u8f7b\u4e86\u60a3\u8005\u7684\u7ecf\u6d4e\u8d1f\u62c5\u3002<\/span><\/span><\/p>\n

\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"<\/o:p><\/span><\/span><\/p>\n

\u00fc <\/span>\u7ecf\u7edf\u8ba1\uff0c<\/span>8 <\/span>\u4e2a\u7eb3\u5165\u533b\u4fdd\u7684\u5355\u6297\u836f\u7269\u5728<\/span>2018 <\/span>\u5e74\u4e0a\u534a\u5e74\u7684\u9500\u552e\u6570\u91cf\u548c\u9500\u552e\u91d1\u989d\uff0c\u591a\u5b9e\u73b0\u4e86\u8f83\u5feb\u7684\u589e\u901f\uff0c\u7279\u522b\u662f\u9500\u552e\u6570\u91cf\uff0c\u8d1d\u4f10\u73e0\u5355\u6297\u5b9e\u73b0\u4e86<\/span>2.67 <\/span>\u500d\u7684\u8fc5\u731b\u589e\u957f\uff0c\u6cbb\u7597\u6076\u6027\u80bf\u7624\u7684\u6cf0\u6b23\u751f\u3001\u66f2\u59a5\u73e0\u5355\u6297\u548c\u5229\u59a5\u6614\u5355\u6297\u9500\u91cf\u589e\u957f\u5747\u8d85\u8fc7\u4e86<\/span>1 <\/span>\u500d\u3002<\/o:p><\/span><\/span><\/p>\n

n <\/span>18 <\/span>\u5e74\u6297\u80bf\u7624\u836f\u533b\u4fdd\u8c08\u5224\uff0c\u897f\u59a5\u6614\u5355\u6297\u6210\u4e3a\u7b2c<\/span>9 <\/span>\u4e2a\u8fdb\u5165\u533b\u4fdd\u76ee\u5f55\u7684\u5355\u6297\u836f\u7269\uff1a<\/o:p><\/span><\/span><\/p>\n

\u00fc <\/span>10 <\/span>\u6708<\/span>10 <\/span>\u65e5\uff0c\u56fd\u5bb6\u533b\u7597\u4fdd\u969c\u5c40\u53d1\u5e03\u300a\u5173\u4e8e\u5c06<\/span>17 <\/span>\u79cd\u6297\u764c\u836f\u7eb3\u5165\u56fd\u5bb6\u57fa\u672c\u533b\u7597\u4fdd\u9669\u3001\u5de5\u4f24\u4fdd\u9669\u548c\u751f\u80b2\u4fdd\u9669\u836f\u54c1\u76ee\u5f55\u4e59\u7c7b\u8303\u56f4\u7684\u901a\u77e5\u300b\uff0c\u5c06\u963f\u624e\u80de\u82f7\u7b49<\/span>17 <\/span>\u79cd\u8c08\u5224\u836f\u54c1\u7eb3\u5165\u533b\u4fdd\u76ee\u5f55\u4e59\u7c7b\uff0c\u5176\u4e2d\u5305\u62ec\u897f\u59a5\u6614\u5355\u6297\u3002\u8fc4\u4eca\uff0c\u5171\u8ba1<\/span>9 <\/span>\u4e2a\u5355\u6297\u836f\u7269\u7eb3\u5165\u533b\u4fdd\u76ee\u5f55\u3002<\/o:p><\/span><\/span><\/p>\n

2.2 <\/span>\u76f8\u5173\u653f\u7b56\u5229\u597d\u6fc0\u53d1\u4f01\u4e1a\u7684\u7814\u53d1\u70ed\u60c5<\/o:p><\/span><\/span><\/p>\n

\u00fc <\/span>2016 <\/span>\u5e74<\/span>2 <\/span>\u6708<\/span>26 <\/span>\u65e5\uff0c<\/span>CFDA <\/span>\u53d1\u5e03\u300a\u603b\u5c40\u5173\u4e8e\u89e3\u51b3\u836f\u54c1\u6ce8\u518c\u7533\u8bf7\u79ef\u538b\u5b9e\u884c\u4f18\u5148\u5ba1\u8bc4\u5ba1\u6279\u7684\u610f\u89c1\u300b\uff0c\u65e8\u5728\u52a0\u5feb\u5177\u6709\u4e34\u5e8a\u4ef7\u503c\u7684\u65b0\u836f\u548c\u4e34\u5e8a\u6025\u9700\u4eff\u5236\u836f\u7684\u7814\u53d1\u4e0a\u5e02\uff0c\u89e3\u51b3\u836f\u54c1\u6ce8\u518c\u7533\u8bf7\u79ef\u538b\u7684\u77db\u76fe\u3002\u5355\u6297\u836f\u7269\u5177\u6709\u660e\u663e\u4e34\u5e8a\u4f18\u52bf\uff0c\u7279\u522b\u662f\u6cbb\u7597\u6076\u6027\u80bf\u7624\u4e00\u7c7b\u662f\u4e34\u5e8a\u6025\u9700\uff0c\u5c5e\u4e8e\u4f18\u5148\u5ba1\u8bc4\u5ba1\u6279\u884c\u5217\uff0c\u672a\u6765\u6709\u671b\u52a0\u901f\u4e0a\u5e02\u3002<\/o:p><\/span><\/span><\/p>\n

\u00fc <\/span>2017 <\/span>\u5e74<\/span>4 <\/span>\u6708<\/span>18 <\/span>\u65e5\uff0c\u4eba\u793e\u90e8\u5c31\u201c\u533b\u4fdd\u76ee\u5f55\u52a8\u6001\u8c03\u6574\u673a\u5236\u201d\u516c\u5f00\u5f81\u6c42\u610f\u89c1\u5efa\u8bae\uff0c\u672a\u6765\u7b26\u5408\u4e34\u5e8a\u9700\u6c42\u548c\u533b\u4fdd\u57fa\u91d1\u627f\u53d7\u80fd\u529b\u7684\u65b0\u4e0a\u5e02\u836f\u54c1\u5c06\u6709\u671b\u901a\u8fc7\u52a8\u6001\u8c03\u6574\u7eb3\u5165\u533b\u4fdd\uff0c\u800c\u4e0d\u9700\u8981\u7b49\u5230<\/span>5-8 <\/span>\u5e74\u4e00\u6b21\u7684\u65b0\u533b\u4fdd\u76ee\u5f55\u51fa\u53f0\u3002\u53d7\u653f\u7b56\u5229\u597d\u5f71\u54cd\uff0c\u5236\u836f\u4f01\u4e1a\u7814\u53d1\u52a8\u529b\u5341\u8db3\uff0c\u53c2\u4e0e\u5355\u6297\u7814\u53d1\u7684\u4f01\u4e1a\u6570\u91cf\u9010\u5e74\u6500\u5347\u3002<\/span><\/span><\/p>\n

\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"<\/o:p><\/span><\/span><\/p>\n

\u00fc <\/span>\u6211\u4eec\u7edf\u8ba1\u4e86\u73b0\u9636\u6bb5\u4e3b\u6d41\u5355\u6297\u836f\u7269\u7684\u7814\u53d1\u8fdb\u5c55\u548c\u7533\u62a5\u73b0\u72b6\uff0c\u8fdb\u5c55\u6700\u8fc5\u901f\u7684\u4e3a\u6309\u7167<\/span>1<\/span>\u7c7b\u65b0\u836f\u7533\u62a5\u7684<\/span>PD-1 <\/span>\u6291\u5236\u5242\uff0c\u76ee\u524d\u5df2\u6709<\/span>4 <\/span>\u5bb6\u4f01\u4e1a\u63d0\u4ea4\u4e0a\u5e02\u7533\u8bf7\uff0c\u5176\u4e2d\uff0c\u541b\u5b9e\u751f\u7269\u7533\u8bf7\u7684\u9996\u4e2a\u9002\u5e94\u75c7\u4e3a\u9ed1\u8272\u7d20\u7624\uff0c\u6052\u745e\u3001\u4fe1\u8fbe\u3001\u767e\u6d4e\u795e\u5dde\u7533\u8bf7\u7684\u9002\u5e94\u75c7\u5747\u4e3a\u970d\u57fa\u91d1\u6dcb\u5df4\u7624\u3002\u6b64\u5916\uff0c\u591a\u4e2a\u751f\u7269\u7c7b\u4f3c\u836f\u4e5f\u6709\u4f01\u4e1a\u63d0\u4ea4\u4e0a\u5e02\u7533\u8bf7\uff0c\u5982\u767e\u5965\u6cf0\u548c\u6d77\u6b63\u836f\u4e1a\u9012\u4ea4\u4e86\u963f\u8fbe\u6728\u5355\u6297\u7684\u4e0a\u5e02\u7533\u8bf7\uff0c\u590d\u5b8f\u6c49\u9716\u3001\u4e09\u751f\u5236\u836f\u3001\u9f50\u9c81\u5236\u836f\u5206\u522b\u9012\u4ea4\u4e86\u5229\u59a5\u6614\u5355\u6297\u3001\u66f2\u59a5\u73e0\u5355\u6297\u3001\u8d1d\u4f10\u73e0\u5355\u6297\u7684\u4e0a\u5e02\u7533\u8bf7\u3002\u9884\u8ba1\u5230\u4eca\u5e74\u5e95\uff0c\u5c06\u4f1a\u6709\u591a\u6b3e\u56fd\u4ea7\u91cd\u78c5\u5355\u6297\u836f\u7269\u4e0a\u5e02\uff0c\u56fd\u5185\u5355\u6297\u5e02\u573a\u6709\u671b\u5168\u9762\u7206\u53d1\u3002\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"<\/o:p><\/span><\/span><\/p>\n

\u4ee5\u201c\u6069\u5229\u201d\u4e3a\u4f8b\uff0c\u65e9\u4e0a\u5e02\u7684\u4ea7\u54c1\u5148\u53d1\u4f18\u52bf\u663e\u8457\u3002<\/span>\u539f\u7814\u836f\u6069\u5229\u662f\u5b89\u8fdb\u751f\u4ea7\u7684\u6297\u4f53\u878d\u5408\u86cb\u767d\u836f\u7269\uff0c\u7528\u4e8e\u6cbb\u7597\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u3001\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u7b49\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u3002\u6069\u5229\u4e8e<\/span>2010 <\/span>\u5e74\u83b7\u6279\u5728\u56fd\u5185\u4e0a\u5e02\uff0c<\/span>2017 <\/span>\u5e74\u6837\u672c\u533b\u9662\u9500\u552e\u989d<\/span>522 <\/span>\u4e07\u5143\u3002\u4e2d\u56fd\u5e02\u573a\u4e0a\u76ee\u524d\u5df2\u6709<\/span>3 <\/span>\u4e2a\u56fd\u4ea7\u7684\u6069\u5229\u751f\u7269\u7c7b\u4f3c\u836f\u4e0a\u5e02\u9500\u552e\u3002\u4e2d\u4fe1\u56fd\u5065\u7684\u201c\u76ca\u8d5b\u666e\u201d\u65e9\u4e8e<\/span>2006 <\/span>\u5e74\u83b7\u6279\uff0c\u65e9\u4e8e\u539f\u7814\u836f<\/span>4 <\/span>\u5e74\u65f6\u95f4\u4e0a\u5e02\uff0c\u9886\u5148\u62a2\u5360\u4e2d\u56fd\u5e02\u573a\u3002\u4e0a\u6d77\u8d5b\u91d1\u548c\u6d77\u6b63\u836f\u4e1a\u7684\u201c\u5f3a\u514b\u201d\u3001\u201c\u5b89\u4f70\u8bfa\u201d\u5206\u522b\u4e8e<\/span>2011 <\/span>\u5e74\u548c<\/span>2015<\/span>\u5e74\u83b7\u6279\u4e0a\u5e02\u3002\u6839\u636e\u6c5f\u82cf\u7701<\/span>2018 <\/span>\u5e74<\/span>3 <\/span>\u6708<\/span>2 <\/span>\u65e5\u516c\u5e03\u7684\u6700\u65b0\u4e2d\u6807\u4ef7\u683c\uff0c\u76ca\u8d5b\u666e\u7684\u4ef7\u683c\u4ec5\u4e3a\u8fdb\u53e3\u4ea7\u54c1\u7684<\/span>30%<\/span>\u5de6\u53f3\uff0c\u5148\u53d1\u5730\u4f4d\u518d\u52a0\u4e0a\u4ef7\u683c\u4f18\u52bf\uff0c\u4f7f\u5f97\u76ca\u8d5b\u666e\u5728\u5176\u540c\u7c7b\u4ea7\u54c1\u4e2d\u5904\u4e8e\u7edd\u5bf9\u9886\u5148\u5730\u4f4d\u3002\u6839\u636e<\/span>PBD <\/span>\u6570\u636e\u5e93\u6837\u672c\u533b\u9662\u7528\u836f\u60c5\u51b5\u7edf\u8ba1\uff0c<\/span>2017 <\/span>\u5e74\u76ca\u8d5b\u666e\u7684\u5e02\u573a\u4efd\u989d\u5df2\u8fbe<\/span>86%<\/span>\u3002\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"<\/span><\/span><\/p>\n

3. <\/span>\u56db\u7c7b\u5355\u6297\u5728\u56fd\u5185\u6700\u5177\u53d1\u5c55\u524d\u666f<\/o:p><\/span><\/span><\/p>\n

\u6211\u4eec\u8ba4\u4e3a\uff0c\u5728\u56fd\u5185\u5177\u6709\u53d1\u5c55\u524d\u666f\u7684\u5355\u6297\u836f\u7269\u5e94\u5177\u6709\u5982\u4e0b\u4e00\u4e2a\u6216\u51e0\u4e2a\u7279\u5f81\uff1a<\/span>1<\/span>\uff09\u91cd\u5927\u75be\u75c5\u7528\u836f\uff0c\u5bf9\u5e94\u9002\u5e94\u75c7\u5728\u56fd\u5185\u53d1\u75c5\u7387\u548c\u81f4\u6b7b\u7387\u5747\u8f83\u9ad8\uff0c\u5e02\u573a\u7a7a\u95f4\u5927\uff1b<\/span>2<\/span>\uff09\u4e34\u5e8a\u7597\u6548\u663e\u8457\u597d\u4e8e\u5176\u4ed6\u6cbb\u7597\u836f\u7269\uff1b<\/span>3<\/span>\uff09\u653f\u5e9c\u6307\u5bfc\u6276\u6301\u7528\u836f\uff1b<\/span>4<\/span>\uff09\u5168\u7403\u9500\u552e\u989d\u5927\u7684\u91cd\u78c5\u836f\u7269\uff1b<\/span>5<\/span>\uff09\u5728\u5168\u7403\u6709\u4e00\u5b9a\u7684\u9500\u552e\u989d\u4e14\u9500\u552e\u589e\u901f\u5927\u7684\u65b0\u836f\uff1b<\/span>6<\/span>\uff09\u5df2\u8fc7\u6216\u5c06\u8fc7\u4e13\u5229\u671f\u7684\u836f\u3002\u6839\u636e\u4ee5\u4e0a\u6761\u4ef6\uff0c\u6211\u4eec\u7b5b\u9009\u51fa\u56db\u5927\u7c7b\u5355\u6297\u836f\u7269\uff0c\u5206\u522b\u4e3a\uff1a\u7f57\u6c0f\u4e09\u5927\u91cd\u78c5\u6297\u80bf\u7624\u836f\u3001\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u7528\u836f\u3001\u773c\u5e95\u75be\u75c5\u7528\u836f\u3001\u4ee5<\/span>PD-1\/PD-L1 <\/span>\u4e3a\u9776\u70b9\u65b0\u836f\uff0c\u5e76\u5bf9\u5176\u56fd\u5185\u5916\u5e02\u573a\u548c\u56fd\u5185\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\u8fdb\u884c\u4e86\u68b3\u7406\u3002\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"<\/o:p><\/span><\/span><\/p>\n

3.1 <\/span>\u4e09\u5927\u91cd\u78c5\u6297\u80bf\u7624\u836f<\/o:p><\/span><\/span><\/p>\n

\u6297\u80bf\u7624\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\u5373\u5c06\u5728\u6b27\u6d32\u4e0a\u5e02\u3002<\/span>\u5229\u59a5\u6614\u5355\u6297\u662f\u7b2c\u4e00\u4e2a\u901a\u8fc7<\/span>FDA <\/span>\u8ba4\u8bc1\u7684\u6297\u80bf\u7624\u5355\u6297\u836f\u7269\uff0c\u53ef\u5168\u9762\u63d0\u9ad8\u60a3\u8005\u603b\u751f\u5b58\u7387\uff0c\u4ec5\u4f34\u968f\u6781\u5c0f\u7684\u6bd2\u526f\u4f5c\u7528\uff0c\u8fd1\u51e0\u5e74\u9500\u552e\u989d\u4fdd\u6301\u7a33\u5b9a\u3002\u539f\u7814\u836f<\/span>Rituxan <\/span>\u5728\u7f8e\u56fd\u548c\u6b27\u6d32\u7684\u4e13\u5229\u5206\u522b\u4e8e<\/span>2018 <\/span>\u5e74\u548c<\/span>2015 <\/span>\u5e74\u5230\u671f\u3002<\/span>2017 <\/span>\u5e74<\/span>2 <\/span>\u6708\uff0c\u97e9\u56fd\u751f\u7269\u5236\u836f\u516c\u53f8<\/span>trion <\/span>\u7684\u4eff\u5236\u836f<\/span>Truxima <\/span>\u83b7\u5f97<\/span>EMA <\/span>\u4e0a\u5e02\u6279\u51c6\uff0c\u9002\u5e94\u75c7\u5305\u62ec\u539f\u7814\u836f\u7684\u6240\u6709\u80bf\u7624\u9002\u5e94\u75c7\uff0c\u662f\u6b27\u7f8e\u89c4\u8303\u5e02\u573a\u4e0a\u552f\u4e00\u83b7\u6279\u7684\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\u3002<\/span>Truxima <\/span>\u76ee\u524d\u8fd8\u6ca1\u6709\u4e0a\u5e02\u9500\u552e\uff0c<\/span>trion <\/span>\u516c\u53f8\u8868\u793a\u8be5\u4ea7\u54c1\u5b9a\u4ef7\u5c06\u4f1a\u6bd4\u539f\u7814\u836f\u4fbf\u5b9c<\/span>30%-40%<\/span>\u3002<\/o:p><\/span><\/span><\/p>\n

\u975e\u89c4\u8303\u5e02\u573a\u5df2\u6709\u5229\u59a5\u6614\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\u4e0a\u5e02\uff0c\u5bf9\u539f\u7814\u836f\u5e02\u573a\u51b2\u51fb\u5de8\u5927\u3002<\/span>\u5728\u975e\u89c4\u8303\u5e02\u573a\uff0c\u5370\u5ea6\u7684\u5236\u836f\u516c\u53f8<\/span>Dr. Reddy\u2019s <\/span>\u65e9\u4e8e<\/span>2007 <\/span>\u5e74\u63a8\u51fa\u9996\u4e2a\u5229\u59a5\u6614\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\u3002\u4fc4\u7f57\u65af<\/span>Biocad<\/span>\u516c\u53f8\u7684\u5229\u59a5\u6614\u5355\u6297\u7c7b\u4f3c\u836f\u4e5f\u4e8e<\/span>2014 <\/span>\u5e74\u5728\u4fc4\u7f57\u65af\u83b7\u6279\u4e0a\u5e02\uff0c\u5bf9\u539f\u7814\u836f\u5728\u4fc4\u5e02\u573a\u9020\u6210\u4e86\u5f88\u5927\u7684\u5e02\u573a\u51b2\u51fb\uff0c<\/span>Rituxan <\/span>\u5f53\u5e74\u9500\u552e\u6536\u5165\u540c\u6bd4\u4e0b\u964d<\/span>70%<\/span>\uff0c\u7b2c\u4e8c\u5e74\u9500\u552e\u6536\u5165\u7ee7\u7eed\u540c\u6bd4\u4e0b\u6ed1<\/span>47%<\/span>\u3002\u751f\u7269\u7c7b\u4f3c\u836f\u51ed\u501f\u9ad8\u6027\u4ef7\u6bd4\u53ef\u5feb\u901f\u62a2\u5360\u539f\u7814\u836f\u7684\u5e02\u573a\u4efd\u989d\u3002<\/o:p><\/span><\/span><\/p>\n

\u5229\u59a5\u6614\u5355\u6297\u7684\u9002\u5e94\u75c7\u4e3a\u975e\u970d\u57fa\u91d1\u6dcb\u5df4\u7624\u3002<\/span>\u6839\u636e\u300a<\/span>Cancer statistics in China, 2015<\/span>\u300b\u7684\u6570\u636e\u6211\u56fd\u6bcf\u5e74\u65b0\u589e\u6dcb\u5df4\u7624\u53d1\u75c5\u4eba\u6570\u7ea6\u4e3a<\/span>8.82 <\/span>\u4e07\uff0c\u5176\u4e2d\u7ea6\u6709<\/span>91%<\/span>\u5c5e\u4e8e\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u3002\u5176\u4e2d\u5229\u59a5\u6614\u5728\u4e2d\u56fd\u83b7\u6279\u9002\u5e94\u75c7\u5f25\u6f2b\u6027\u5927<\/span>B <\/span>\u7ec6\u80de\u6dcb\u5df4\u7624\u4e0e\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u6240\u5206\u522b\u5360<\/span>30%<\/span>\u4e0e<\/span>25%<\/span>\u3002\u8fd9\u90e8\u5206\u60a3\u8005\u4e2d\u6709<\/span>98%<\/span>\u7684\u6982\u7387\u8868\u8fbe<\/span>CD20 <\/span>\u9633\u6027\u3002<\/o:p><\/span><\/span><\/p>\n

\u66f2\u59a5\u73e0\u5355\u6297\u7684\u9002\u5e94\u75c7\u4e3a\u4e73\u817a\u764c\u548c\u80c3\u764c\u3002<\/span>\u4e73\u817a\u764c\u5c45\u6211\u56fd\u5973\u6027\u6076\u6027\u80bf\u7624\u53d1\u75c5\u7387\u9996\u4f4d\uff0c\u6839\u636e<\/span>2017<\/span>\u5e74\u4e2d\u56fd\u80bf\u7624\u767b\u8bb0\u4e2d\u5fc3\u6570\u636e\uff0c<\/span>2014 <\/span>\u5e74\u6211\u56fd\u4e73\u817a\u764c\u65b0\u53d1\u75c5\u4f8b\u7ea6<\/span>27.9 <\/span>\u4e07\uff0c\u5e76\u4ee5\u6bcf\u5e74<\/span>2%<\/span>\u5de6\u53f3\u7684\u901f\u5ea6\u9012\u589e\u3002\u5176\u4e2d\u7ea6<\/span>15%-20%<\/span>\u7684\u60a3\u8005\u5b58\u5728<\/span>HER2 <\/span>\u57fa\u56e0\u7684\u6269\u589e\u53ca\u5176\u7f16\u7801\u86cb\u767d\u7684\u8fc7\u8868\u8fbe\u3002\u6839\u636e\u8d6b\u8d5b\u6c40\u836f\u54c1\u8bf4\u660e\u4e66\u7684\u7528\u836f\u5242\u91cf\u6307\u5bfc\u4ee5\u53ca\u4e2d\u56fd\u5973\u6027\u5e73\u5747\u4f53\u91cd\uff08<\/span>57.3kg<\/span>\uff0c\u56fd\u5bb6\u536b\u8ba1\u59d4<\/span>2015 <\/span>\u5e74\u6570\u636e\uff09\u6d4b\u7b97\uff0c\u60a3\u8005\u4eba\u5747\u6bcf\u5e74\u4f7f\u7528\u6570\u91cf\u7ea6<\/span>14-16 <\/span>\u74f6\uff08<\/span>440mg\/<\/span>\u74f6\uff09\uff0c\u964d\u4ef7\u8fdb\u5165\u533b\u4fdd\u540e\u5355\u4ef7\u4e3a<\/span>7600<\/span>\u5143<\/span>\/<\/span>\u74f6\uff0c\u603b\u5e02\u573a\u7a7a\u95f4\u53ef\u8fbe<\/span>68 <\/span>\u4ebf\u5143\u4eba\u6c11\u5e01\u3002<\/o:p><\/span><\/span><\/p>\n

\u6211\u56fd\u662f\u80c3\u764c\u9ad8\u53d1\u56fd\u5bb6\uff0c\u53d1\u75c5\u7387\u4ec5\u6b21\u4e8e\u80ba\u764c\uff0c\u53d1\u75c5\u4eba\u6570\u548c\u6b7b\u4ea1\u4f8b\u6570\u5747\u7ea6\u5360\u4e16\u754c\u7684<\/span>50%<\/span>\u3002\u6839\u636e<\/span>2017 <\/span>\u5e74\u4e2d\u56fd\u80bf\u7624\u767b\u8bb0\u4e2d\u5fc3\u6570\u636e\uff0c<\/span>2014 <\/span>\u5e74\u6211\u56fd\u80c3\u764c\u65b0\u53d1\u75c5\u4f8b\u4e3a<\/span>41.0 <\/span>\u4e07\uff0c\u5176\u4e2d\u7ea6<\/span>15%<\/span>\u60a3\u8005<\/span>HER <\/span>\u8868\u8fbe\u5448\u73b0\u9633\u6027\u3002\u6839\u636e\u8d6b\u8d5b\u6c40\u836f\u54c1\u8bf4\u660e\u4e66\u7684\u7528\u836f\u5242\u91cf\u6307\u5bfc\u4ee5\u53ca\u4e2d\u56fd\u4eba\u5e73\u5747\u4f53\u91cd\uff08<\/span>61.8kg<\/span>\uff0c\u56fd\u5bb6\u536b\u8ba1\u59d4<\/span>2015 <\/span>\u5e74\u6570\u636e\uff09\u6d4b\u7b97\uff0c\u60a3\u8005\u4eba\u5747\u4f7f\u7528\u6570\u91cf\u7ea6<\/span>16 <\/span>\u74f6\uff08<\/span>440mg\/<\/span>\u74f6\uff09\uff0c\u964d\u4ef7\u8fdb\u5165\u533b\u4fdd\u540e\u5355\u4ef7\u4e3a<\/span>7600 <\/span>\u5143<\/span>\/<\/span>\u74f6\uff0c\u603b\u5e02\u573a\u7a7a\u95f4\u53ef\u8fbe<\/span>75 <\/span>\u4ebf\u5143\u4eba\u6c11\u5e01\u3002<\/o:p><\/span><\/span><\/p>\n

\u8d1d\u4f10\u73e0\u5355\u6297\u7684\u9002\u5e94\u75c7\u4e3a\u7ed3\u76f4\u80a0\u764c\u548c\u80ba\u764c\u3002<\/span>\u7ed3\u76f4\u80a0\u764c\u662f\u6211\u56fd\u9ad8\u53d1\u6076\u6027\u80bf\u7624\uff0c\u6211\u56fd\u6bcf\u5e74\u65b0\u53d1\u75c5\u4f8b\u7ea6<\/span>37.6 <\/span>\u4e07\u3002<\/span>50%<\/span>\u7684\u60a3\u8005\u4f1a\u9762\u4e34\u590d\u53d1\u548c\u8f6c\u79fb\uff0c\u6709\u62a5\u9053\u6307\u51fa\u4e2d\u56fd\u4eba\u7fa4\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\uff0c\u7ea6<\/span>40%<\/span>\u5b58\u5728<\/span>KRAS <\/span>\u57fa\u56e0\u7a81\u53d8\uff0c\u7ea6<\/span>3.2%<\/span>\u5b58\u5728<\/span>NRAS <\/span>\u57fa\u56e0\u7a81\u53d8<\/span>,<\/span>\u7ea6<\/span>5%<\/span>\u5b58\u5728<\/span>BRAF <\/span>\u57fa\u56e0\u7a81\u53d8\uff0c\u6240\u4ee5\u7ea6\u6709<\/span>48%<\/span>\u8f6c\u79fb\u60a3\u8005\u9002\u7528\u5b89\u7ef4\u6c40\u3002\u6839\u636e\u5b89\u7ef4\u6c40\u836f\u54c1\u8bf4\u660e\u4e66\u7684\u7528\u836f\u5242\u91cf\u6307\u5bfc<\/span>5mg\/kg<\/span>\uff0c\u6bcf<\/span>2 <\/span>\u5468\u7528\u4e00\u6b21\u836f\uff0c\u4e2d\u56fd\u4eba\u5e73\u5747\u4f53\u91cd<\/span>61.8kg<\/span>\uff0c\u5219\u60a3\u8005\u6bcf\u5e74\u4f7f\u7528\u6570\u91cf\u7ea6<\/span>78 <\/span>\u74f6\uff08<\/span>100mg \/<\/span>\u74f6\uff09\uff0c\u8fdb\u5165\u533b\u4fdd\u540e\u5355\u4ef7\u4e3a<\/span>1998 <\/span>\u5143<\/span>\/<\/span>\u74f6\uff0c\u603b\u5e02\u573a\u7a7a\u95f4\u53ef\u8fbe<\/span>140.7 <\/span>\u4ebf\u5143\u4eba\u6c11\u5e01\u3002<\/o:p><\/span><\/span><\/p>\n

\u80ba\u764c\u662f\u6211\u56fd\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u5747\u6392\u5728\u7b2c<\/span>1 <\/span>\u7684\u6076\u6027\u80bf\u7624\uff0c\u6bcf\u5e74\u80ba\u764c\u65b0\u53d1\u75c5\u4f8b\u7ea6<\/span>73.3 <\/span>\u4e07\u3002\u7ea6<\/span>80%<\/span>\u7684\u80ba\u764c\u60a3\u8005\u662f\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3002\u800c\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\uff0c\u8fdb\u5165\u665a\u671f\u6216\u8005\u53d1\u751f\u8f6c\u79fb\u7684\u6bd4\u4f8b\u7ea6\u4e3a<\/span>30%<\/span>\u3002\u6839\u636e\u5b89\u7ef4\u6c40\u836f\u54c1\u8bf4\u660e\u4e66\u7684\u7528\u836f\u5242\u91cf\u6307\u5bfc<\/span>15mg\/kg<\/span>\uff0c\u6bcf<\/span>3 <\/span>\u5468\u7528\u4e00\u6b21\u836f\uff0c\u7528\u836f\u4e0d\u8d85\u8fc7<\/span>6 <\/span>\u5468\u671f\uff0c\u60a3\u8005\u4eba\u5747\u7528\u836f\u91cf\u7ea6\u4e3a<\/span>56 <\/span>\u74f6\uff08<\/span>100mg \/<\/span>\u74f6\uff09\uff0c\u603b\u5e02\u573a\u7a7a\u95f4\u53ef\u8fbe<\/span>197 <\/span>\u4ebf\u5143\u4eba\u6c11\u5e01\u3002<\/o:p><\/span><\/span><\/p>\n

\u6211\u56fd\u591a\u5bb6\u4f01\u4e1a\u7533\u62a5\u7814\u53d1\uff0c\u8fdb\u5c55\u4e0d\u4e00\u3002<\/span>\u9488\u5bf9\u7f57\u6c0f\u4e09\u5927\u91cd\u78c5\u6297\u80bf\u7624\u836f\uff0c\u56fd\u5185\u73b0\u6709\u591a\u5bb6\u56fd\u4ea7\u4f01\u4e1a\u5df2\u7533\u62a5\u4e34\u5e8a\u6216\u6b63\u5728\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\u3002\u5229\u59a5\u6614\u5355\u6297\u5df2\u7ecf\u7533\u62a5\u4e0a\u5e02\u7684\u6709\u590d\u5b8f\u6c49\u9716\uff08\u83b7\u4f18\u5148\u5ba1\u8bc4\uff09\uff0c\u8fdb\u5165\u4e34\u5e8a\u4e09\u671f\u7684\u4f01\u4e1a\u6709\u4fe1\u8fbe\u751f\u7269\u3001\u795e\u5dde\u7ec6\u80de\u3001\u6d77\u6b63\u836f\u4e1a\uff1b\u66f2\u59a5\u73e0\u5355\u6297\u5df2\u7ecf\u7533\u62a5\u4e0a\u5e02\u7684\u6709\u4e09\u751f\u5236\u836f\uff0c\u8fdb\u5165\u4e09\u671f\u4e34\u5e8a\u7684\u4f01\u4e1a\u6709\u590d\u5b8f\u6c49\u9716\u3001\u5609\u548c\u751f\u7269\u3001\u5b89\u79d1\u751f\u7269\u3001\u767e\u5965\u6cf0\u751f\u7269\u3001\u6d77\u6b63\u836f\u4e1a\uff1b\u8d1d\u4f10\u73e0\u5355\u6297\u7533\u62a5\u4e34\u5e8a\u7684\u6709\u9f50\u9c81\u5236\u836f\uff0c\u8fdb\u5165\u4e09\u671f\u4e34\u5e8a\u7684\u4f01\u4e1a\u6709\u5b89\u79d1\u751f\u7269\u3001\u4fe1\u8fbe\u751f\u7269\u3001\u6c83\u68ee\u751f\u7269\u3001\u5929\u5e7f\u5b9e\u3001\u5c71\u4e1c\u535a\u5b89\u3001\u767e\u5965\u6cf0\u751f\u7269\u3001\u590d\u5b8f\u6c49\u9716\u3001\u534e\u5170\u751f\u7269\u3001\u6052\u745e\u533b\u836f\u3001\u6b63\u5927\u5929\u6674\u3002<\/o:p><\/span><\/span><\/p>\n

\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"<\/o:p><\/span><\/p>\n

3.2 <\/span>\u4e09\u5927\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u7528\u836f<\/o:p><\/span><\/span><\/p>\n

TNF-<\/span>\u03b1\u6291\u5236\u5242\u7c7b\u5355\u6297\u662f\u56fd\u9645\u4e0a\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u7684\u9996\u9009\u6cbb\u7597\u836f\u7269\u3002<\/span>\u963f\u8fbe\u6728\u5355\u6297\u3001\u4f9d\u90a3\u897f\u666e\u3001\u82f1\u592b\u5229\u897f\u5355\u6297\u5747\u5c5e\u4e8e<\/span>TNF-<\/span>\u03b1\u6291\u5236\u5242\u4ea7\u54c1\uff0c\u7528\u4e8e\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u3001\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u7b49\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u3002<\/span>2017 <\/span>\u5e74\u5168\u7403\u9500\u552e\u989d\u5206\u522b\u4e3a<\/span>189<\/span>\u3001<\/span>83<\/span>\u3001<\/span>78 <\/span>\u4ebf\u7f8e\u5143\uff0c\u4f4d\u4e8e\u5168\u7403\u7545\u9500\u836f\u6392\u884c\u699c\u7b2c<\/span>1<\/span>\u3001<\/span>2<\/span>\u3001<\/span>6 <\/span>\u4f4d\uff0c\u4f4d\u4e8e\u5168\u7403\u7545\u9500\u6297\u7c7b\u98ce\u6e7f\u836f\u7269\u5e02\u573a\u524d\u4e09\u4f4d\u3002\u8fd9<\/span>3 <\/span>\u4e2a\u836f\u7269\u4ee3\u8868\u7684\u6297<\/span>TNF-a <\/span>\u751f\u7269\u5236\u5242\u5df2\u7ecf\u5728\u56fd\u5916\u6210\u4e3a\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u3001\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u53ca\u94f6\u5c51\u75c5\u6027\u5173\u8282\u708e\u7684\u9996\u9009\u6cbb\u7597\u65b9\u6848\u3002\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"<\/o:p><\/span><\/span><\/p>\n

\u4f46\u5728\u56fd\u5185\uff0c\u56e0\u6cbb\u7597\u8d39\u7528\u8fc7\u9ad8\u4e14\u591a\u4e0d\u5728\u533b\u4fdd\u8303\u7574\u5185\uff0c\u5bfc\u81f4\u56fd\u5185\u5e02\u573a\u589e\u957f\u7f13\u6162\uff0c\u56fd\u5185\u5e02\u573a\u7684<\/o:p><\/span><\/p>\n

\u9500\u552e\u989d\u8fdc\u8fdc\u843d\u540e\u4e8e\u56fd\u9645\u5e02\u573a\u3002<\/span>\u963f\u8fbe\u6728\u5355\u6297\u3001\u4f9d\u90a3\u897f\u666e\u3001\u82f1\u592b\u5229\u897f\u5355\u6297<\/span>2017 <\/span>\u5e74\u6837\u672c\u9500\u552e\u989d\u5206\u522b\u7ea6\u4e3a<\/span>1800 <\/span>\u4e07\u5143\u3001<\/span>1600 <\/span>\u4e07\u5143\u3001\u548c<\/span>1.67 <\/span>\u4ebf\u5143\u3002\u963f\u8fbe\u6728\u5355\u6297\u4e0e\u4f9d\u90a3\u897f\u666e\u90fd\u4e8e<\/span>2010 <\/span>\u5e74\u6279\u51c6\u8fdb\u53e3\uff0c\u82f1\u592b\u5229\u897f\u5355\u6297<\/span>2006 <\/span>\u5e74\u83b7\u6279\u8fdb\u53e3\uff0c\u7531\u4e8e\u6279\u51c6\u8fdb\u53e3\u65f6\u95f4\u65e9\u4e8e\u4e0a\u8ff0\u4e24\u6b3e\u540c\u7c7b\u836f\u7269\uff0c\u5e02\u573a\u4e5f\u76f8\u5bf9\u8f83\u5927\u3002\u867d\u7136\u6b64\u6b21\u82f1\u592b\u5229\u897f\u5355\u6297\u4e5f\u88ab\u7eb3\u5165\u533b\u4fdd\u8c08\u5224\u76ee\u5f55\uff0c\u4f46\u9650\u7528\u4e8e\u514b\u7f57\u6069\u75c5\uff0c\u6700\u7ec8\u6ca1\u6709\u8c08\u5224\u6210\u529f\uff0c\u5c06\u4fdd\u6301\u539f\u4ef7\u3002<\/o:p><\/span><\/span><\/p>\n

\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"<\/o:p><\/span><\/p>\n

\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u7c7b\u5355\u6297\u836f\u7269\u540e\u7eed\u589e\u957f\u6f5c\u529b\u5927\uff0c\u4f46\u5e02\u573a\u7ade\u4e89\u975e\u5e38\u6fc0\u70c8\uff0c\u76ee\u524d\u662f<\/span>3+3+2+6 <\/span>\u683c\u5c40\u3002<\/o:p><\/span><\/span><\/p>\n

\u56fd\u5185\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u3001\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u60a3\u8005\u7ea6\u5404\u6709<\/span>500 <\/span>\u4e07\u4eba\uff0c\u6b64\u524d\u7531\u4e8e\u751f\u7269\u5236\u5242\u4ef7\u683c\u592a\u8d35\u4e14\u5927\u591a\u6570\u5730\u533a\u90fd\u6ca1\u6709\u88ab\u7eb3\u5165\u533b\u4fdd\u7684\u56e0\u7d20\uff0c\u4ec5\u6709\u6781\u5c11\u6570\u60a3\u8005\u4f1a\u4f7f\u7528\u751f\u7269\u5236\u5242\uff0c\u6e17\u900f\u7387\u4e0d\u5230<\/span>0.2%<\/span>\u3002\u9274\u4e8e\u4e2d\u56fd\u6e17\u900f\u7387\u8f83\u5168\u7403\u5e02\u573a\u4e3a\u4f4e\uff0c\u540e\u7eed\u7684\u5e02\u573a\u589e\u957f\u6f5c\u529b\u8fd8\u5f88\u5927\u3002\u6309\u7167\u76ca\u8d5b\u666e\u7684\u4ef7\u683c\u548c\u7597\u7a0b\u6765\u8ba1\u7b97\uff0c\u82e5\u6709<\/span>1%<\/span>\u7684\u60a3\u8005\u9009\u62e9\u4f7f\u7528\u76ca\u8d5b\u666e\u8fdb\u884c\u6cbb\u7597\uff0c\u5176\u5e02\u573a\u53ef\u8fbe<\/span>67 <\/span>\u4ebf\u5143\u3002\u4f46\u76ee\u524d\u56fd\u5185\u5df2\u7ecf\u6709<\/span>3 <\/span>\u4e2a\u8fdb\u53e3\u54c1\u79cd\u548c<\/span>3 <\/span>\u4e2a\u56fd\u4ea7\u54c1\u79cd\uff0c<\/span>2 <\/span>\u4e2a\u54c1\u79cd\u63d0\u4ea4\u4e0a\u5e02\u7533\u8bf7\uff0c\u8fd8\u6709<\/span>6 <\/span>\u4e2a\u56fd\u4ea7\u54c1\u79cd\u5df2\u8fdb\u5165\u4e34\u5e8a<\/span>III <\/span>\u671f\uff0c\u5e02\u573a\u7ade\u4e89\u5f02\u5e38\u6fc0\u70c8\u3002<\/span><\/span><\/p>\n

\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"<\/o:p><\/span><\/p>\n

3.3 <\/span>\u773c\u5e95\u75be\u75c5\u7528\u836f<\/o:p><\/span><\/span><\/p>\n

\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u73ed\u53d8\u6027\uff08<\/span>AMD<\/span>\uff09\u53ef\u5206\u4e3a\u5e72\u6027\uff08\u975e\u65b0\u751f\u8840\u7ba1\u6027\uff09\u548c\u6e7f\u6027\uff08\u65b0\u751f\u8840\u7ba1\u6027\uff09\u4e24\u79cd\uff0c\u6e7f\u6027\u5360<\/span>AMD <\/span>\u603b\u53d1\u75c5\u6570\u4e0d\u5230<\/span>20%<\/span>\uff0c\u5374\u9020\u6210\u4e86<\/span>80-90%<\/span>\u7684\u4e0d\u53ef\u9006\u4e2d\u5fc3\u89c6\u529b\u4e27\u5931\uff0c\u662f\u5bfc\u81f4\u8001\u5e74\u4eba\u5931\u660e\u7684\u91cd\u8981\u75be\u75c5\u4e4b\u4e00\u3002\u56fd\u9645\u5e02\u573a\u4e0a\uff0c\u8bfa\u534e\u751f\u4ea7\u7684\u6cbb\u7597\u6e7f\u6027<\/span>AMD <\/span>\u7684\u96f7\u73e0\u5355\u6297\u65e9\u4e8e<\/span>2006<\/span>\u5e74\u4e0a\u5e02\uff0c\u9500\u552e\u989d\u6301\u7eed\u6500\u5347\u3002<\/span>2011 <\/span>\u5e74\uff0c\u62dc\u5c14\u7684\u963f\u67cf\u897f\u666e\u4e0a\u5e02\uff0c\u4e0e\u96f7\u73e0\u5355\u6297\u5f62\u6210\u7ade\u4e89\u5173\u7cfb\u3002\u963f\u67cf\u897f\u666e\u548c\u96f7\u73e0\u5355\u6297\u90fd\u662f<\/span>VEGF <\/span>\u6291\u5236\u5242\uff0c\u901a\u8fc7\u6291\u5236\u8840\u7ba1\u65b0\u751f\u6539\u5584\u75c5\u60c5\uff0c\u662f\u76ee\u524d\u6700\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u4e0e\u96f7\u73e0\u5355\u6297\u76f8\u6bd4\uff0c\u963f\u67cf\u897f\u666e\u4ef7\u683c\u7565\u4f4e\uff0c\u7ed9\u836f\u9891\u7387\u4f4e\uff0c\u6cbb\u7597\u6210\u672c\u53ea\u6709\u96f7\u73e0\u5355\u6297\u7684\u4e00\u534a\u800c\u6548\u679c\u7565\u597d\uff0c\u56e0\u6b64\u5168\u7403\u5e02\u573a\u4efd\u989d\u5feb\u901f\u63d0\u5347\uff0c\u5728<\/span>2015 <\/span>\u5e74\u9996\u8d85\u96f7\u73e0\u5355\u6297\uff0c\u968f\u540e\u6301\u7eed\u62c9\u5f00\u5dee\u8ddd\u3002\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"\u963f\u67cf\u897f\u666e\u4e8e<\/span>2018 <\/span>\u5e74<\/span>2 <\/span>\u6708\u5728\u6211\u56fd\u83b7\u6279\u4e0a\u5e02\u6cbb\u7597\u7cd6\u5c3f\u75c5\u6027\u9ec4\u6591\u6c34\u80bf\u3002\u56fd\u5185\u5e02\u573a\u4e0a\u6cbb\u7597<\/span>wAMD<\/span>\u7684\u5355\u6297\u836f\u7269\u4e3b\u8981\u6709\u96f7\u73e0\u5355\u6297\u548c\u5eb7\u67cf\u897f\u666e\uff0c\u5e02\u573a\u4efd\u989d\u5927\u4f53\u76f8\u5f53\u3002\u5eb7\u67cf\u897f\u666e\u662f\u5eb7\u5f18\u836f\u4e1a\u81ea\u4e3b\u7814\u53d1\u7684\u4ea7\u54c1\uff0c<\/span>2013 <\/span>\u5e74\u4e0a\u5e02\u4ee5\u6765\u589e\u957f\u8fc5\u901f\uff0c<\/span>2016 <\/span>\u5e74\u5b9e\u73b0\u9500\u552e\u6536\u5165<\/span>4.76 <\/span>\u4ebf\u5143\uff0c\u540c\u6bd4\u589e\u957f<\/span>78%<\/span>\u3002\u9500\u552e\u6536\u5165\u5360\u516c\u53f8\u603b\u6536\u5165\u7684<\/span>18.74%<\/span>\uff0c\u5448\u9010\u5e74\u4e0a\u5347\u8d8b\u52bf\u3002\u5eb7\u67cf\u897f\u666e\u548c\u96f7\u73e0\u5355\u6297\u7ecf\u8c08\u5224\u540e\u90fd\u88ab\u7eb3\u5165\u533b\u4fdd\u76ee\u5f55\uff0c\u964d\u5e45\u5206\u522b\u4e3a\u4ec5\u4e3a<\/span>17%<\/span>\u548c<\/span>20%<\/span>\u3002\u4e24\u4e2a\u6cbb\u7597\u6e7f\u6027<\/span>AMD <\/span>\u7684\u5355\u6297\u836f\u7269\u540c\u65f6\u7ecf\u8c08\u5224\u8fdb\u5165\u76ee\u5f55\uff0c\u4e14\u964d\u4ef7\u5e45\u5ea6\u5c0f\uff0c\u4f53\u73b0\u4e86\u56fd\u5bb6\u5bf9\u8be5\u75be\u75c5\u7684\u9ad8\u5ea6\u91cd\u89c6\u3002\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"<\/o:p><\/span><\/span><\/p>\n

n <\/span>\u5eb7\u67cf\u897f\u666e\u4e0e\u963f\u67cf\u897f\u666e\u7c7b\u4f3c\uff0c\u76f8\u8f83\u8fdb\u53e3\u7684\u96f7\u73e0\u5355\u6297\u6709\u8bf8\u591a\u4f18\u52bf\uff1a<\/o:p><\/span><\/span><\/p>\n

\u00fc <\/span>\u7ed9\u836f\u9891\u7387\uff1a\u96f7\u73e0\u5355\u6297\u662f\u6297\u4f53\u7247\u6bb5\uff0c\u534a\u8870\u671f\u8f83\u77ed\uff0c\u6240\u4ee5\u5fc5\u987b\u6bcf\u6708\u7ed9\u836f<\/span>1 <\/span>\u6b21\uff0c\u7528\u836f\u8f83\u4e3a\u9891\u7e41\u3002\u800c\u5eb7\u67cf\u897f\u666e\u5de7\u5999\u5730\u5229\u7528\u6297\u4f53\u878d\u5408\u86cb\u767d\uff0c\u901a\u8fc7\u5ef6\u957f\u534a\u8870\u671f\u5ef6\u957f\u4e86\u836f\u6548\u3002\u7ed9\u836f\u9891\u7387\u4e3a\u524d<\/span>3 <\/span>\u4e2a\u6708\u6bcf\u6708\u7ed9\u836f<\/span>1 <\/span>\u6b21\uff0c\u4e4b\u540e\u6bcf<\/span>3 <\/span>\u4e2a\u6708\u7ed9\u836f<\/span>1 <\/span>\u6b21\u3002<\/o:p><\/span><\/span><\/p>\n

\u00fc <\/span>\u56fd\u5185\u83b7\u6279\u773c\u79d1\u65b0\u9002\u5e94\u75c7\uff1a\u96f7\u73e0\u5355\u6297\u548c\u5eb7\u67cf\u897f\u666e\u66fe\u5728\u56fd\u5185\u4ec5\u83b7\u6279\u6cbb\u7597<\/span>wAMD<\/span>\u3002<\/span>2017<\/span>\u5e74<\/span>5 <\/span>\u6708\uff0c\u5eb7\u67cf\u897f\u666e\u83b7\u51c6\u6cbb\u7597\u201c\u75c5\u7406\u6027\u8fd1\u89c6\u7ee7\u53d1\u8109\u7edc\u819c\u65b0\u751f\u8840\u7ba1\uff08<\/span>PM-CNV<\/span>\uff09\u5f15\u8d77\u7684\u89c6\u529b\u4e0b\u964d\u201d\u8fd9\u4e00\u65b0\u9002\u5e94\u75c7\u3002<\/span>wAMD <\/span>\u4e2d\u56fd\u53d1\u75c5\u4eba\u6570\u7ea6<\/span>300 <\/span>\u4e07\u4eba\uff0c\u65b0\u9002\u5e94\u75c7\u53d1\u75c5\u4eba\u6570\u7ea6<\/span>160 <\/span>\u4e07\u4eba\uff0c\u5eb7\u67cf\u897f\u666e\u7406\u8bba\u5e02\u573a\u7a7a\u95f4\u6269\u5bb9\u8d85\u8fc7<\/span>50%<\/span>\u3002\u5eb7\u67cf\u897f\u666e\u6cbb\u7597\u7cd6\u5c3f\u75c5\u9ec4\u6591\u6c34\u80bf\uff08<\/span>DME<\/span>\uff09\u548c\u89c6\u7f51\u819c\u9759\u8109\u963b\u585e\uff08<\/span>RVO<\/span>\uff09\u7684\u62d3\u5c55\u9002\u5e94\u75c7\u4e5f\u5904\u4e8e\u4e34\u5e8a<\/span>III <\/span>\u671f\u9636\u6bb5\uff0c\u9884\u8ba1\u6709\u671b\u5728<\/span>1-2 <\/span>\u5e74\u5185\u83b7\u6279\uff0c\u9884\u8ba1\u672a\u6765\u7528\u836f\u8303\u56f4\u548c\u60a3\u8005\u6570\u91cf\u6709\u671b\u4e0d\u65ad\u6269\u5927\u3002\u636e\u5357\u65b9\u6240\u6d4b\u7b97\uff0c\u6211\u56fd\u6e7f\u6027\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\uff08<\/span>wAMD<\/span>\uff09\u3001\u75c5\u7406\u6027\u8fd1\u89c6\u7ee7\u53d1\u8109\u7edc\u819c\u65b0\u751f\u8840\u7ba1\uff08<\/span>PM-CNV<\/span>\uff09\u3001\u7cd6\u5c3f\u75c5\u9ec4\u6591\u6c34\u80bf\uff08<\/span>DME<\/span>\uff09\u3001\u89c6\u7f51\u819c\u9759\u8109\u963b\u585e\uff08<\/span>RVO<\/span>\uff09\u7684\u53d1\u75c5\u4eba\u6570\u5206\u522b\u4e3a<\/span>300 <\/span>\u4e07\u4eba\u3001<\/span>160 <\/span>\u4e07\u4eba\u3001<\/span>400 <\/span>\u4e07\u4eba\u3001<\/span>300 <\/span>\u4e07\u4eba\uff0c\u5408\u8ba1<\/span>1160 <\/span>\u4e07\u4eba\u3002\u6309\u7167\u533b\u4fdd\u652f\u4ed8\u6807\u51c6\u6bcf\u773c\u6bcf\u5e74\u4e0a\u9650\u662f<\/span>4 <\/span>\u652f\uff0c\u6bcf\u652f\u4ef7\u683c<\/span>5550 <\/span>\u5143\uff0c\u6309\u7167<\/span>5%<\/span>\u7684\u6e17\u900f\u7387\u8ba1\u7b97\uff0c\u5eb7\u67cf\u897f\u666e\u6cbb\u7597<\/span>wAMD <\/span>\u548c\u75c5\u7406\u6027\u8fd1\u89c6\u7684\u7406\u8bba\u5e02\u573a\u7a7a\u95f4\u7ea6<\/span>33 <\/span>\u4ebf\u5143\u548c<\/span>18 <\/span>\u4ebf\u5143\u3002\u82e5\u5176\u4ed6<\/span>2<\/span>\u4e2a\u9002\u5e94\u75c7\u83b7\u6279\uff0c\u603b\u5e02\u573a\u53ef\u8d85\u8fc7<\/span>100 <\/span>\u4ebf\u5143\uff0c\u6f5c\u529b\u5de8\u5927\u3002<\/o:p><\/span><\/span><\/p>\n

\u00fc <\/span>\u62d3\u5c55\u6297\u80bf\u7624\u9002\u5e94\u75c7\uff1a\u96f7\u73e0\u5355\u6297\u548c\u5eb7\u67cf\u897f\u666e\u7684\u5171\u540c\u9776\u70b9<\/span>VEGF <\/span>\u5305\u62ec<\/span>A<\/span>\u3001<\/span>B<\/span>\u3001<\/span>C<\/span>\u3001<\/span>D<\/span>\u3001<\/span>PlGF<\/span>\uff08\u80ce\u76d8\u751f\u957f\u56e0\u5b50\uff09\u4e94\u79cd\u4e9a\u578b\uff0c\u800c\u96f7\u73e0\u5355\u6297\u4ec5\u963b\u65ad<\/span>VEGF-A<\/span>\uff0c\u800c\u5eb7\u67cf\u897f\u666e\u8fd8\u80fd\u963b\u65ad\u5176\u4ed6\u591a\u4e2a\u4e9a\u578b\uff0c\u5982<\/span>PlGF <\/span>\u53ef\u53c2\u4e0e\u591a\u79cd\u80bf\u7624\u751f\u6210\uff0c\u56e0\u6b64\uff0c\u5eb7\u67cf\u897f\u666e\u5728\u7406\u8bba\u4e0a\u6709\u66f4\u5e7f\u9614\u7684\u9002\u5e94\u75c7\u3002<\/o:p><\/span><\/span><\/p>\n

\u7814\u53d1\u65b9\u9762\uff0c\u76ee\u524d\u56fd\u5185\u6295\u5165\u8be5\u7c7b\u4ea7\u54c1\u7684\u7814\u53d1\u4f01\u4e1a\u4e0d\u591a\uff0c\u4ec5\u6709\u9f50\u9c81\u5236\u836f\u7b49<\/span>6 <\/span>\u5bb6\u4f01\u4e1a\u8fdb\u5165\u4e34\u5e8a<\/span>I<\/span>\u671f\u3002\u9884\u8ba1\u672a\u6765<\/span>3-5 <\/span>\u5e74\u65f6\u95f4\u5185\uff0c\u56fd\u5185\u773c\u5e95\u75be\u75c5\u6297\u4f53\u836f\u7269\u5e02\u573a\u7531\u5eb7\u67cf\u897f\u666e\u7b49<\/span>3 <\/span>\u4e2a\u4ea7\u54c1\u5360\u636e\uff0c\u5e02\u573a\u7ade\u4e89\u683c\u5c40\u8f83\u597d\u3002<\/span><\/span><\/p>\n

\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"<\/o:p><\/span><\/p>\n

3.4 <\/span>\u540e\u8d77\u4e4b\u79c0<\/span>PD-1<\/span>\u3001<\/span>PD-L1 <\/span>\u5355\u6297<\/o:p><\/span><\/span><\/p>\n

2014 <\/span>\u5e74\uff0c\u6297\u80bf\u7624\u5355\u6297<\/span>Opdivo <\/span>\u548c<\/span>Keytruda <\/span>\u7684\u4e0a\u5e02\u9500\u552e\uff0c\u6380\u8d77\u4e86\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u65b0\u9ad8\u6f6e\u3002\u8fd9\u4e24\u6b3e\u836f\u7269\u5747\u662f\u4ee5<\/span>PD-1 <\/span>\u4e3a\u9776\u70b9\uff0c\u901a\u8fc7\u6fc0\u6d3b\u88ab\u6291\u5236\u7684\u514d\u75ab\u7cfb\u7edf\u6765\u653b\u51fb\u80bf\u7624\u7ec6\u80de\uff0c\u5177\u6709\u5e7f\u6cdb\u7684\u6297\u80bf\u7624\u9002\u5e94\u75c7\u3002<\/span>2016 <\/span>\u5e74\u5e95\u81f3\u4eca\uff0c\u4ee5<\/span>PD-L1 <\/span>\u4e3a\u9776\u70b9\u7684\u5355\u6297\u836f\u7269<\/span>Tecentriq<\/span>\u3001<\/span>Bavencio<\/span>\u3001<\/span>Imfinzi<\/span>\u76f8\u7ee7\u4e0a\u5e02\uff0c\u4f5c\u7528\u673a\u7406\u7c7b\u4f3c\u4e8e<\/span>Opdivo <\/span>\u548c<\/span>Keytruda<\/span>\u3002<\/span>2018 <\/span>\u5e74\uff0c\u7b2c\u4e09\u4e2a\u4ee5<\/span>PD-1 <\/span>\u4e3a\u9776\u70b9\u7684\u836f\u7269<\/span>Libtayo <\/span>\u83b7\u6279\u6cbb\u7597\u665a\u671f\u8f6c\u79fb\u6027\u76ae\u80a4\u9cde\u72b6\u7ec6\u80de\u764c\u3002\u636e\u6743\u5a01\u671f\u520a\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\u7f16\u59d4\u8868\u8ff0\uff0c<\/span>PD-1 <\/span>\u6297\u4f53\u7684\u6548\u679c\u662f\u8fc7\u53bb<\/span>30 <\/span>\u5e74\u91cc\u6297\u764c\u6548\u679c\u6700\u597d\u7684\u3002<\/span>PD-1 <\/span>\u76f8\u5173\u7684\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u4e5f\u4f5c\u4e3a\u65b0\u7684\u7279\u5f02\u6027\u6297\u80bf\u7624\u7597\u6cd5\uff0c\u8363\u81ba<\/span>2018 <\/span>\u5e74\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66<\/span>\/<\/span>\u533b\u5b66\u5956\u3002\u76ee\u524d<\/span>Opdivo <\/span>\u5728<\/span>FDA <\/span>\u83b7\u6279\u4e86\u591a\u4e2a\u6297\u80bf\u7624\u9002\u5e94\u75c7\uff0c<\/span>2017 <\/span>\u5e74\u9500\u552e\u989d\u8fbe<\/span>58.15 <\/span>\u4ebf\u7f8e\u5143\uff0c\u540c\u6bd4\u589e\u957f<\/span>23%<\/span>\uff0c\u6392\u5728\u5168\u7403\u7545\u9500\u836f\u7269\u6392\u884c\u699c\u7b2c<\/span>11 <\/span>\u4f4d\u3002<\/span>Opdivo <\/span>\u548c<\/span>Keytruda <\/span>\u90fd\u5728<\/span>2018 <\/span>\u5e74\u83b7\u6279\u8fdb\u5165\u4e2d\u56fd\uff0c\u9002\u5e94\u75c7\u5206\u522b\u4e3a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u548c\u9ed1\u8272\u7d20\u7624\u3002\u76ee\u524d\u56fd\u5185\u5df2\u6709\u591a\u5bb6\u4f01\u4e1a\u5e03\u5c40\u56fd\u4ea7<\/span>PD-1 <\/span>\u5355\u6297\u7c7b\u836f\u7269\u4e14\u53d6\u5f97\u4e86\u8f83\u5feb\u7684\u8fdb\u5c55\uff0c\u76ee\u524d\u5df2\u6709<\/span>4 <\/span>\u5bb6\u4f01\u4e1a\u63d0\u4ea4\u4e0a\u5e02\u7533\u8bf7\uff0c\u5176\u4e2d\uff0c\u541b\u5b9e\u751f\u7269\u7533\u8bf7\u7684\u9996\u4e2a\u9002\u5e94\u75c7\u4e3a\u9ed1\u8272\u7d20\u7624\uff0c\u6052\u745e\u3001\u4fe1\u8fbe\u3001\u767e\u6d4e\u795e\u5dde\u7533\u8bf7\u7684\u9002\u5e94\u75c7\u5747\u4e3a\u970d\u57fa\u91d1\u6dcb\u5df4\u7624\u3002\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"\"\u6536\u85cf|\u5355\u6297\u836f\u7269\u6df1\u5ea6\u62a5\u544a\"<\/o:p><\/span><\/span><\/p>\n

2017 <\/span>\u5e74\uff0c\u5168\u7403\u5355\u6297\u4ea7\u54c1\u7a81\u7834\u5343\u4ebf\u7f8e\u5143\uff0c\u591a\u6b3e\u5355\u6297\u836f\u7269\u7a33\u5c45\u7545\u9500\u836f\u6392\u884c\u699c\u524d\u5217\u3002\u4f46\u53d7\u5236\u4e8e\u533b\u4fdd\u652f\u4ed8\u3001\u836f\u7269\u53ef\u53ca\u6027\u3001\u4ee5\u53ca\u533b\u751f\u60a3\u8005\u5904\u65b9\u7528\u836f\u4e60\u60ef\u7b49\u6761\u4ef6\u7684\u9650\u5236\uff0c\u56fd\u5185\u5355\u6297\u5e02\u573a\u89c4\u6a21\u5c1a\u5c0f\uff0c\u5b58\u5728\u8f83\u5927\u7684\u8865\u9f50\u9700\u6c42\u3002<\/span>2017 <\/span>\u5e74\u65b0\u7248\u533b\u4fdd\u76ee\u5f55\u9996\u6b21\u5c06\u66f2\u59a5\u73e0\u5355\u6297\u7b49<\/span>8 <\/span>\u4e2a\u5355\u6297\u836f\u7269\u7eb3\u5165\u652f\u4ed8\uff0c\u5728<\/span>2018 <\/span>\u5e74\u4e0a\u534a\u5e74\u591a\u5b9e\u73b0\u4e86\u8f83\u5feb\u7684\u653e\u91cf\uff1b\u4e14<\/span>2018 <\/span>\u5e74\u897f\u59a5\u6614\u5355\u6297\u4e5f\u901a\u8fc7\u8c08\u5224\u7eb3\u5165\u533b\u4fdd\u76ee\u5f55\uff0c\u6b64\u524d\u5728\u6211\u56fd\u957f\u671f\u53d7\u5230\u6291\u5236\u7684\u5355\u6297\u836f\u7269\u5e02\u573a\u9700\u6c42\u5f97\u4ee5\u91ca\u653e\u3002<\/span>2018 <\/span>\u5e74\u4ee5\u6765\uff0c\u4ee5\u963f\u67cf\u897f\u666e\u3001<\/span>Opdivo<\/span>\u3001<\/span>Keytruda <\/span>\u7b49\u4e3a\u4ee3\u8868\u7684\u5355\u6297\u836f\u7269\u5728\u6211\u56fd\u52a0\u901f\u83b7\u6279\uff0c\u9884\u8ba1\u672a\u6765\u4e5f\u6709\u671b\u901a\u8fc7\u8c08\u5224\u9646\u7eed\u7eb3\u5165\u533b\u4fdd\u3002\u968f\u7740\u8bf8\u591a\u91cd\u78c5\u54c1\u79cd\u4e13\u5229\u5230\u671f\uff0c\u751f\u7269\u7c7b\u4f3c\u836f\u4e3a\u56fd\u5185\u5355\u6297\u5e02\u573a\u53d1\u5c55\u5960\u5b9a\u4e86\u57fa\u7840\u3002<\/span><\/span><\/p>\n

\u6587\u7ae0\u4fe1\u606f\u6e90\u4e8e<\/span>\u516c\u4f17\u53f7<\/span>\u6297\u4f53\u5708<\/span>\uff0c<\/span>\u767b\u8f7d\u8be5\u6587\u7ae0\u76ee\u7684\u4e3a\u66f4\u5e7f\u6cdb\u7684\u4f20\u9012\u884c\u4e1a\u4fe1\u606f\uff0c\u4e0d\u4ee3\u8868\u8d5e\u540c\u5176\u89c2\u70b9\u6216\u5bf9\u5176\u771f\u5b9e\u6027\u8d1f\u8d23\u3002\u6587\u7ae0\u7248\u6743\u5f52\u539f\u4f5c\u8005\u53ca\u539f\u51fa\u5904\u6240\u6709\uff0c\u6587\u7ae0\u5185\u5bb9\u4ec5\u4f9b\u53c2\u8003\u3002\u672c\u7f51\u62e5\u6709\u5bf9\u6b64\u58f0\u660e\u7684\u6700\u7ec8\u89e3\u91ca\u6743\uff0c\u82e5\u65e0\u610f\u4fb5\u72af\u7248\u6743\uff0c\u8bf7\u8054\u7cfb\u5c0f\u7f16\u5220\u9664\u3002<\/span><\/p>\n<\/p>\n

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\u5b66\u5982\u9006\u6c34\u884c\u821f\uff0c\u4e0d\u8fdb\u5219\u9000\uff1b<\/span><\/p>\n

\u5fc3\u4f3c\u5e73\u539f\u8d70\u9a6c\uff0c\u6613\u653e\u96be\u6536\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u533b\u836f\u5927\u6570\u636e|\u884c\u4e1a\u52a8\u6001|\u653f\u7b56\u89e3\u8bfb<\/span><\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

\u70b9\u51fb\u4e0a\u65b9\u7684  \u25b2 \u6dfb\u52a0\u5173\u6ce8 1. \u5168\u7403\u5e02\u573a\u53d1\u5c55\u8fc5\u901f 1.1  […]<\/p>\n","protected":false},"author":1,"featured_media":73821,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/73820"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=73820"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/73820\/revisions"}],"predecessor-version":[{"id":73872,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/73820\/revisions\/73872"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/73821"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=73820"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=73820"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=73820"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}