{"id":7386,"date":"2018-06-14T01:00:00","date_gmt":"2018-07-27T09:23:21","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e5%9b%bd%e9%99%85%e5%b7%a8%e5%a4%b4%e9%87%8d%e9%87%91%e5%8a%a0%e7%a0%81%e7%bb%86%e8%83%9e%e6%b2%bb%e7%96%97%ef%bc%8c%e5%95%86%e4%b8%9a%e5%8c%96%e8%bf%9b%e7%a8%8b%e6%9c%89%e6%9c%9b%e8%b6%85%e9%a2%84\/"},"modified":"2018-07-27T17:23:24","modified_gmt":"2018-07-27T09:23:24","slug":"%e5%9b%bd%e9%99%85%e5%b7%a8%e5%a4%b4%e9%87%8d%e9%87%91%e5%8a%a0%e7%a0%81%e7%bb%86%e8%83%9e%e6%b2%bb%e7%96%97%ef%bc%8c%e5%95%86%e4%b8%9a%e5%8c%96%e8%bf%9b%e7%a8%8b%e6%9c%89%e6%9c%9b%e8%b6%85%e9%a2%84","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/7386\/","title":{"rendered":"\u56fd\u9645\u5de8\u5934\u91cd\u91d1\u52a0\u7801\u7ec6\u80de\u6cbb\u7597\uff0c\u5546\u4e1a\u5316\u8fdb\u7a0b\u6709\u671b\u8d85\u9884\u671f"},"content":{"rendered":"
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\u56fd\u9645\u5de8\u5934\u7eb7\u7eb7\u5e03\u5c40CAR-T\u4e1a\u52a1\uff0c\u8bfa\u534e\u3001\u5409\u5217\u5fb7(KitePharma)\u3001\u65b0\u57fa(JunoTherapeutics)\u4e09\u5de8\u5934\u9886\u8dd1\u3002<\/span><\/p>\n


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\u81ea\u4ece\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66CarlHJune\u6559\u6388\u5b9e\u73b0CAR-T\u7ec6\u80de\u6cbb\u7597\u540e\uff0c\u56fd\u9645\u4e0a\u5df2\u6709\u591a\u5bb6\u516c\u53f8\u5f00\u5c55CAR-T\u7597\u6cd5\u7684\u8fdb\u4e00\u6b65\u63a2\u7d22\u3002<\/span><\/p>\n


<\/p>\n

\u6700\u65e9\u8fdb\u884cCAR-T\u7ec6\u80de\u6cbb\u7597\u5f00\u53d1\u7684\u4e09\u5bb6\u516c\u53f8\u4e3a\u8bfa\u534e\u3001KitePharma\u4ee5\u53caJunoTherapeutics\uff0cKitePharma\u88ab\u5409\u5217\u5fb7\u4ee5119\u4ebf\u7f8e\u5143\u6536\u8d2d\uff0cJuno\u88ab\u65b0\u57fa\u4ee590\u4ebf\u7f8e\u5143\u6536\u8d2d\u5269\u4f5990%\u80a1\u6743\uff0c\u4ea4\u6613\u5b8c\u6210\u540e\uff0cJuno\u6210\u4e3a\u65b0\u57fa\u5168\u8d44\u5b50\u516c\u53f8\u3002<\/span><\/p>\n


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2018\u5e743\u6708\uff0c\u7531\u51ef\u7279\u5236\u836f(KitePharma)\u4e24\u4f4d\u524d\u9ad8\u7ba1\u521b\u529e\u7684AllogeneTherapeutics\u83b7\u5f973\u4ebf\u7f8e\u5143\u878d\u8d44\uff0c\u521b\u4e0b\u4e86\u521d\u521b\u516c\u53f8\u7684\u878d\u8d44\u4f30\u503c\u548c\u878d\u8d44\u901f\u5ea6\u7684\u8bb0\u5f55\u3002<\/span><\/p>\n


<\/p>\n

\u8bfa\u534e\u5236\u836f(Novartis)\u4f5c\u4e3a\u8fdb\u5165CAR-T\u9886\u57df\u7684\u8f83\u65e9\u7684\u5236\u836f\u516c\u53f8\uff0c\u4e0e\u7f8e\u56fd\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u7684\u5408\u4f5c\uff0c\u5df2\u7ecf\u62e5\u6709\u9886\u5148\u7684CAR-T\u7814\u53d1\u7ba1\u7ebf\uff0c\u6210\u529f\u5165\u9a7b\u7b2c\u4e00\u68af\u961f\u3002<\/span><\/p>\n


<\/p>\n

2014\u5e747\u6708\u6839\u636e\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7(IND)\uff0c\u5c06CTL019\u7528\u4e8e\u6cbb\u7597\u513f\u7ae5\u548c\u6210\u4eba\u590d\u53d1\u6216\u96be\u6cbb\u6027\u7684\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5(ALL)\u60a3\u8005;2015\u5e744\u6708\u5728\u5168\u7403\u8303\u56f4\u5185\u542f\u52a8\u4e86CTL019\u6cbb\u7597ALL\u76842\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c12\u6708\u4e2d\u671f\u4e34\u5e8a\u6570\u636e\u663e\u793a\u63a5\u53d7CTL019\u6cbb\u7597\u540e\uff0c\u5b8c\u5168\u7f13\u89e3\u7387\u8fbe\u5230\u4e8693%\u3002<\/span><\/p>\n


<\/p>\n

2017\u5e748\u6708CTL019(Kymriah)\u83b7\u5f97FDA\u6279\u51c6\u4e0a\u5e02\uff0c\u6210\u4e3a\u4eba\u7c7b\u5386\u53f2\u4e0a\u9996\u4e2a\u4e0a\u5e02CAR-T\u6cbb\u7597\u4ea7\u54c1\u3002<\/span><\/p>\n


<\/p>\n

\u51ef\u7279\u5236\u836f(KitePharma)\u662fCAR-T\u6cbb\u7597\u65b0\u661f\uff0c\u5df2\u88ab\u5409\u5217\u5fb7\u4ee5119\u4ebf\u7f8e\u5143\u6536\u8d2d\u30022016\u5e749\u6708Kite\u516c\u5e03\u4e86KTE-C19\u7684\u4e8c\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\u671f\u6570\u636e\uff0c\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\u60a3\u8005\u603b\u4f53\u53cd\u5e94\u7387\u8fbe\u523076%\uff0c\u5b8c\u5168\u7f13\u89e3\u7387\u8fbe\u523047%;\u8f6c\u79fb\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\u60a3\u8005\u603b\u4f53\u53cd\u5e94\u7387\u8fbe\u523091%\uff0c\u5b8c\u5168\u7f13\u89e3\u7387\u8fbe\u523073%\u3002<\/span><\/p>\n


<\/p>\n

\u540c\u5e7412\u6708KitePharma\u5df2\u5c31\u5176CAR-T\u7597\u6cd5KTE-C19\u5411FDA\u63d0\u4ea4\u4e0a\u5e02\u6ce8\u518c\u7533\u8bf7\uff0c\u9488\u5bf9\u7684\u9002\u5e94\u75c7\u4e3a\u4e0d\u9002\u5408\u81ea\u4f53\u5e72\u7ec6\u80de\u79fb\u690d\u7684\u590d\u53d1\/\u96be\u6cbb\u4fb5\u88ad\u6027B\u7ec6\u80de\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624(NHL)\u30022017\u5e7410\u6708\u5176\u4ea7\u54c1KTE-C19(Yescarta)\u83b7\u5f97FDA\u6279\u51c6\u4e0a\u5e02\u3002<\/span><\/p>\n


<\/p>\n

JunoTherapeutics\uff0c\u5df2\u88ab\u65b0\u57fa\u516c\u53f8(Celgene)\u4ee590\u4ebf\u7f8e\u5143\u6536\u8d2d\uff0cJuno\u4e0e\u7eaa\u5ff5\u65af\u9686-\u51ef\u7279\u6797\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3(MemorialSloanKetteringCancerCenter)\u3001\u5f17\u96f7\u5fb7\u00b7\u54c8\u91d1\u68ee\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3\u4ee5\u53ca\u897f\u96c5\u56fe\u513f\u7ae5\u533b\u9662(SeattleChildren’sHospital)\u4e09\u5bb6\u7814\u7a76\u4e2d\u5fc3\u5408\u4f5c\uff0c\u96c6\u7ed3\u4e86\u9886\u57df\u5185\u9876\u5c16\u7684\u4e13\u5bb6\u3002<\/span><\/p>\n


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\u5c3d\u7ba1\u9996\u4e2a\u4e34\u5e8a\u4ea7\u54c1JCAR015\u56e0\u4e25\u91cd\u526f\u4f5c\u7528\u800c\u7ec8\u6b62\uff0c\u53e6\u5916\u4e24\u4e2a\u7814\u53d1\u9879\u76eeJCAR014\u548cJCAR017\u4e34\u5e8a\u7ed3\u679c\u8f83\u597d\uff0c\u4e3aJuno\u5e26\u6765\u4e86\u66d9\u5149;JCAR017\u5728\u4e34\u5e8a\u6570\u636e\u4e0a\u7684\u8868\u73b0\u6bd4KTE-C19\u66f4\u4f18\u79c0\uff0cJCAR017\u6216\u5c06\u6210\u4e3a\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u60a3\u8005\u7684\u65b0\u9009\u62e9\uff0c\u6709\u6210\u4e3aBest-in-Class\u4ea7\u54c1\u7684\u6f5c\u8d28\u3002<\/span><\/p>\n


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\u76ee\u524d\u7ecf\u8fc7\u6539\u8fdb\u7684JCAR017\u5728\u6cbb\u7597\u590d\u53d1\u6216\u96be\u6cbb\u7684B\u7ec6\u80de\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u4e2d\uff0c\u670943\u4f8b\u53ef\u8bc4\u4f30\u6848\u4f8b\uff0c3\u4e2a\u6708\u7684\u603b\u4f53\u53cd\u5e94\u7387ORR\u4e3a80%\uff0c\u5b8c\u5168\u7f13\u89e3\u7387CR\u4e3a73%\uff0c\u9884\u8ba1Juno\u5c06\u4e8e\u4eca\u5e74\u4e0b\u534a\u5e74\u63d0\u4ea4CAR-T\u6ce8\u518c\u7533\u8bf7\uff0c\u6700\u5feb\u5c06\u4e8e\u5e74\u5185\u83b7\u6279\u3002<\/span><\/p>\n


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\"\u56fd\u9645\u5de8\u5934\u91cd\u91d1\u52a0\u7801\u7ec6\u80de\u6cbb\u7597\uff0c\u5546\u4e1a\u5316\u8fdb\u7a0b\u6709\u671b\u8d85\u9884\u671f\"<\/p>\n


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\u81ea2012\u5e74\u8bfa\u534e\u548cCarlJune\u6559\u6388\u5408\u4f5c\u5f00\u53d1CAR-T\u7597\u6cd5\u4ee5\u6765\uff0c\u7f8e\u56fd\u591a\u5bb6\u5927\u578b\u836f\u4f01\u52a0\u5165\u4e86CAR-T\u7814\u53d1\u7ade\u4e89\u7684\u884c\u5217\uff0c\u7eb7\u7eb7\u4e0eCAR-T\u7814\u53d1\u516c\u53f8\u5408\u4f5c\uff0cJuno\u3001Kite\u3001Cellectis\u3001Bluebird\u3001\u5357\u4eac\u4f20\u5947\u7b49\u516c\u53f8\u76ee\u524d\u5747\u4e0e\u8de8\u56fd\u836f\u4f01\u5de8\u5934\u7b7e\u7f72\u4e86\u7814\u53d1\u6216\u9500\u552e\u5408\u4f5c\u534f\u8bae\u3002<\/span><\/p>\n


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\u7ec6\u80de\u6cbb\u7597\u4ecd\u5b58\u4e24\u5927\u9884\u671f\u5dee<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u7ec6\u80de\u6cbb\u7597\u5728\u4e8c\u7ea7\u5e02\u573a\u5df2\u83b7\u5f97\u8f83\u9ad8\u5173\u6ce8\u5ea6\uff0c\u4f46\u6211\u4eec\u8ba4\u4e3a\u4ecd\u5b58\u4e24\u5927\u9884\u671f\u5dee\uff0c\u7b2c\u4e00\uff0c\u7ec6\u80de\u7597\u6cd5\u7684\u5546\u4e1a\u4ef7\u503c\u4ecd\u672a\u88ab\u5e02\u573a\u5145\u5206\u8ba4\u8bc6;\u7b2c\u4e8c\u7ec6\u80de\u7597\u6cd5\u7684\u5546\u4e1a\u5316\u8fdb\u7a0b\u53ef\u80fd\u88ab\u4f4e\u4f30\u3002
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\u80a1\u4ef7\u5e76\u672a\u5b8c\u5168\u53cd\u5e94\u7ec6\u80de\u6cbb\u7597\u7684\u5546\u4e1a\u6f5c\u529b:\u5168\u7403\u7ec6\u80de\u6cbb\u7597\u9f99\u5934KitePharma\u5e02\u503c120\u4ebf\u7f8e\u5143\uff0cJunoTherapeutics\u5e02\u503c100\u4ebf\u7f8e\u5143\uff0cBluebird\u5e02\u503c85\u4ebf\u7f8e\u5143\uff0c\u6211\u56fd\u7ec6\u80de\u6cbb\u7597\u9f99\u5934\u516c\u53f8\u91d1\u65af\u745e\u751f\u7269\u79d1\u6280\u5e03\u5c40\u4e0eBluebird\u3001Juno\u76f8\u8fd1\uff0cLCAR-B38M-CAR-T\u5728\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u9002\u5e94\u75c7\u7814\u53d1\u8fdb\u5ea6\u7b2c\u4e00\u3002<\/span><\/p>\n


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\u4e34\u5e8a\u8868\u73b0\u4e0a\uff0c2017\u5e74ASCO\u5927\u4f1a\u4e0a\uff0c\u975e\u5b8c\u5168\u53ef\u6bd4\u53e3\u5f84\uff0c\u5357\u4eac\u4f20\u5947\u7684LCAR-B38M\u5f55\u5f97\u66f4\u9ad8\u5b8c\u5168\u7f13\u89e3\u7387(73%vs27%)\uff0c\u9996\u627925\u4f4d\u6cbb\u7597\u60a3\u8005\u5df2\u6cbb\u7597\u8d85\u8fc71\u5e74\uff0c\u5176\u4e2d20\u4f4d\u4ecd\u7ef4\u6301\u5b8c\u5168\u7f13\u89e3\u72b6\u6001\uff0c\u5177\u6709\u6210\u4e3aFirst-in-Class\u53caBest-in-Class\u4ea7\u54c1\u7684\u6f5c\u529b\uff0c\u5e02\u503c\u4ec5445\u4ebf\u6e2f\u5143(\u5bf9\u5e9457\u4ebf\u7f8e\u5143)\u3002<\/span><\/p>\n


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\u5e02\u573a\u4e3b\u6d41\u89c2\u70b9\u8ba4\u4e3a\u7ec6\u80de\u6cbb\u7597\u53ea\u80fd\u7528\u4e8e\u590d\u53d1\u96be\u6cbb\u8840\u6db2\u80bf\u7624\uff0c\u5e02\u573a\u7a7a\u95f4\u76f8\u5bf9\u8f83\u5c0f\uff0c\u6211\u4eec\u8ba4\u4e3a\u968f\u7740\u7814\u53d1\u63a8\u8fdb\uff0c\u7ec6\u80de\u6cbb\u7597\u5c06\u7528\u4e8e\u975e\u590d\u53d1\u96be\u6cbb\u8840\u6db2\u80bf\u7624\u53ca\u5b9e\u4f53\u7624\uff0c\u6709\u671b\u628a\u80bf\u7624\u53d8\u6210\u6162\u6027\u75c5\uff0c\u5e02\u573a\u7a7a\u95f4\u5de8\u5927\u3002<\/span><\/p>\n


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\"\u56fd\u9645\u5de8\u5934\u91cd\u91d1\u52a0\u7801\u7ec6\u80de\u6cbb\u7597\uff0c\u5546\u4e1a\u5316\u8fdb\u7a0b\u6709\u671b\u8d85\u9884\u671f\"<\/p>\n

\"\u56fd\u9645\u5de8\u5934\u91cd\u91d1\u52a0\u7801\u7ec6\u80de\u6cbb\u7597\uff0c\u5546\u4e1a\u5316\u8fdb\u7a0b\u6709\u671b\u8d85\u9884\u671f\"<\/p>\n


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\u5e02\u573a\u4e3b\u6d41\u89c2\u70b9\u8ba4\u4e3a\u7ec6\u80de\u6cbb\u7597\u5728\u6211\u56fd\u5546\u4e1a\u5316\u5c1a\u65e9\uff0c\u8fd8\u6ca1\u5230\u8d21\u732e\u5229\u6da6\u7684\u65f6\u5019\uff0c\u6211\u4eec\u8ba4\u4e3a\u9f99\u5934\u516c\u53f8\u6709\u6280\u672f\u79ef\u7d2f\uff0c\u6709\u5546\u4e1a\u5316\u80fd\u529b\uff0c\u836f\u5ba1\u9f13\u52b1\u521b\u65b0\u548c\u6025\u9700\u7528\u836f\uff0c\u5546\u4e1a\u5316\u8fdb\u7a0b\u6709\u671b\u8d85\u51fa\u5e02\u573a\u9884\u671f\uff0c\u6700\u5feb\u6709\u671b\u57282019\u5e74\u521d\u5b9e\u73b0\u5546\u4e1a\u5316\u3002<\/strong><\/span><\/p>\n


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\u5e02\u573a\u4e3b\u6d41\u89c2\u70b9\u5bf9\u7ec6\u80de\u6cbb\u7597\u7814\u53d1\u516c\u53f8\u8fdb\u884c\u63a8\u8350\uff0c\u6211\u4eec\u8ba4\u4e3a\u7ec6\u80de\u6cbb\u7597\u7814\u53d1\u670d\u52a1\u5546\u4e5f\u540c\u6837\u503c\u5f97\u5173\u6ce8\uff0c\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u5b89\u5168\u6027\u8bc4\u4ef7\u5e02\u573a\u7a7a\u95f4\u572815-21\u4ebf\u4e4b\u95f4<\/strong>\uff0c\u4e14\u968f\u7740\u65b0\u589e\u9776\u70b9\u63a8\u8fdb\uff0c\u5e02\u573a\u9700\u6c42\u4f1a\u6301\u7eed\u589e\u957f\uff0c\u91cd\u70b9\u63a8\u8350\u7ec6\u80de\u6cbb\u7597\u5b89\u5168\u6027\u8bc4\u4ef7\u9886\u57df\u76f8\u5173\u6807\u7684\u3002<\/span><\/p>\n


<\/p>\n

\u6b64\u5916\uff0c\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u6162\u75c5\u6bd2\u8f7d\u4f53\u5e02\u573a\u7a7a\u95f4\u572810\u4ebf\u5143\u5de6\u53f3\uff0c\u4e14\u6162\u75c5\u6bd2\u8f7d\u4f53\u8bc4\u4ef7\u5468\u671f\u957f\u3001\u58c1\u5792\u9ad8\uff0c\u968f\u7740\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u7684\u4e0a\u5e02\uff0c\u6709\u671b\u5f62\u6210\u7c7b\u4f3c\u72ec\u5bb6CMO\u4f9b\u5e94\u6a21\u5f0f\uff0c\u5efa\u8bae\u5173\u6ce8\u6162\u75c5\u6bd2\u8f7d\u4f53\u4f9b\u5e94\u5546\u3002<\/span><\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
<\/section>\n
\n

\u9884\u671f\u5dee\u4e4b\u4e00:\u5546\u4e1a\u4ef7\u503c\u88ab\u4f4e\u4f30<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u4e0d\u4ec5\u4ec5\u662f\u201c\u590d\u53d1\u96be\u6cbb\u201d\u80bf\u7624<\/strong><\/span><\/p>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n

\u76ee\u524d\u5df2\u83b7\u6279\u4e0a\u5e02\u7684Kymriah\u548cYescarta\u9002\u5e94\u75c7\u5747\u4e3a\u590d\u53d1\u96be\u6cbb\u8840\u6db2\u80bf\u7624\uff0c\u4f46\u8fd9\u662f\u51fa\u4e8e\u4f26\u7406\u5b66\u7684\u8981\u6c42\u548c\u6ce8\u518c\u7b56\u7565\u7684\u9009\u62e9\u3002<\/span><\/p>\n


<\/p>\n

\u6211\u4eec\u8ba4\u4e3a\uff0c\u8fd9\u5e76\u4e0d\u610f\u5473\u7740\u7ec6\u80de\u6cbb\u7597\u5fc5\u987b\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u96be\u6cbb\u7684\u8840\u6db2\u80bf\u7624\uff0c\u800c\u662f\u6709\u671b\u5411\u524d\u63a8\u79fb\u3002<\/span><\/p>\n


<\/p>\n

\u4ee5\u81ea\u4f53\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u6cbb\u7597\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u4e3a\u4f8b\uff0c\u76ee\u524d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u4e3a3-5\u5e74\uff0c\u4ee5\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u4e34\u5e8a\u9636\u6bb5\u7684\u8868\u73b0\uff0c\u6709\u53ef\u80fd\u66ff\u4ee3\u81ea\u4f53\u9020\u8840\u809d\u7ec6\u80de\u79fb\u690d\u3002<\/span><\/p>\n


<\/p>\n

\u9884\u8ba1\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u7f6e\u4e3a\u8bd5\u9a8c\u7ec4(\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1)\u3001\u5bf9\u7167\u7ec4(\u81ea\u4f53\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d)\uff0c\u6bd4\u8f83\u4e8c\u7ec4\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff0c\u5047\u8bbe\u7ec6\u80de\u6cbb\u7597\u83b7\u5f97\u66f4\u597d\u7684\u4e34\u5e8a\u6570\u636e\uff0c\u7ec6\u80de\u6cbb\u7597\u7684\u5e02\u573a\u5c06\u4ece\u590d\u53d1\u96be\u6cbb\u8840\u6db2\u80bf\u7624\u62d3\u5c55\u5230\u975e\u590d\u53d1\u96be\u6cbb\u8840\u6db2\u80bf\u7624\u3002<\/span><\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u4ece\u8840\u6db2\u80bf\u7624\u5230\u5b9e\u4f53\u7624<\/strong><\/span><\/p>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n

\u867d\u7136\u7ec6\u80de\u6cbb\u7597\u5728\u8840\u6db2\u80bf\u7624\u4e0a\u5df2\u7ecf\u8bc1\u660e\u7597\u6548\uff0c\u4f46\u662f\u5728\u5b9e\u4f53\u7624\u4e0a\u7684\u5e94\u7528\u524d\u666f\u5219\u5b58\u5728\u5206\u6b67\uff0c\u6211\u4eec\u8ba4\u4e3a\u7ec6\u80de\u6cbb\u7597\u4e0b\u4e00\u4e2a\u91cd\u8981\u76ee\u6807\u5c31\u662f\u653b\u514b\u5b9e\u4f53\u7624\uff0c\u76ee\u524d\u7ec6\u80de\u6cbb\u7597\u7528\u4e8e\u5b9e\u4f53\u7624\u5df2\u7ecf\u5728\u90e8\u5206\u764c\u79cd\u548c\u9776\u70b9\u4e0a\u53d6\u5f97\u8ba9\u4eba\u6fc0\u52a8\u7684\u6210\u679c\u3002<\/span><\/p>\n


<\/p>\n

2015\u5e7411\u6708\uff0c\u7f8e\u56fd\u80bf\u7624\u514d\u75ab\u5b66\u5e74\u4f1a(SITC2015),NY-ESO-1\u9776\u70b9TCR-T\u7597\u6cd5\u7684\u7528\u4e8e\u6ed1\u819c\u8089\u7624\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e(NCT01343043)\u53d1\u8868\uff0c\u603b\u4f53\u5e94\u7b54\u7387\u8fbe\u523050%\uff0c\u800c\u4e14T\u7ec6\u80de\u5728\u60a3\u8005\u4f53\u5185\u6301\u7eed\u5b58\u6d3b\u3002<\/span><\/p>\n


<\/p>\n

2018\u5e742\u6708\uff0cScienceTranslationalMedicine\u62a5\u9053\uff0c\u65af\u5766\u798f\u5927\u5b66\u533b\u5b66\u9662\u7684\u7814\u7a76\u4eba\u5458\u5c06\u4e24\u79cd\u514d\u75ab\u523a\u6fc0\u5242(OX40\u6297\u4f53\u4ee5\u53caCpG\u7684\u5be1\u6838\u82f7\u9178\u77edDNA\u7247\u6bb5-TLR9)\u76f4\u63a5\u6ce8\u5c04\u523090\u53ea\u5c0f\u9f20\u7684\u5b9e\u4f53\u7624\u4e2d\uff0c\u6709\u6548\u6d88\u966487\u53ea\u5c0f\u9f20\u4f53\u5185\u6240\u6709\u7684\u764c\u75c7\u75d5\u8ff9\uff0c\u53e6\u59163\u53ea\u80bf\u7624\u590d\u53d1\uff0c\u5728\u7ecf\u8fc7\u7b2c\u4e8c\u6b21\u6cbb\u7597\u540e\u90fd\u518d\u6b21\u6d88\u9000\u3002<\/span><\/p>\n


<\/p>\n

2018\u5e743\u6708\uff0cNature\u6742\u5fd7\u53d1\u8868\u4e00\u7ec4\u6765\u81ea\u65e5\u672c\u7684\u79d1\u5b66\u5bb6\u56e2\u961f\u7684\u7814\u7a76\uff0c\u901a\u8fc7\u5c06IL-17\u4ee5\u53caCCL-19\u57fa\u56e0\u8f6c\u5165CAR-T\u7ec6\u80de\u5236\u5907\u51fa\u80fd\u591f\u6709\u6548\u6740\u4f24\u80bf\u7624\u7684\u201c\u8d85\u7ea7CAR-T\u7ec6\u80de\u201d\uff0c\u5728\u5c0f\u9f20\u5b9e\u9a8c\u4e2d\u6548\u679c\u76f8\u5f53\u60ca\u559c\uff0c\u8377\u7624\u5c0f\u9f20\u751f\u5b58\u7387\u8fbe\u5230100%\uff0c\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u91c7\u7528\u5e38\u89c4CAR-T\u7597\u6cd5\u7684\u80bf\u7624\u5c0f\u9f20\u751f\u5b58\u7387\u53ea\u670930%\u5de6\u53f3\u3002<\/span><\/p>\n


<\/p>\n

\"\u56fd\u9645\u5de8\u5934\u91cd\u91d1\u52a0\u7801\u7ec6\u80de\u6cbb\u7597\uff0c\u5546\u4e1a\u5316\u8fdb\u7a0b\u6709\u671b\u8d85\u9884\u671f\"<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n


<\/p>\n

\u56fd\u5185\u4f01\u4e1a\u5728\u5b9e\u4f53\u7624\u6cbb\u7597\u5927\u6f6e\u4e2d\u6fc0\u6d41\u52c7\u8fdb<\/strong><\/span><\/p>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n

\u79d1\u6d4e\u751f\u72692017\u5e74\u516c\u5e03\u4e86\u5168\u7403\u9996\u4e2a\u9488\u5bf9GPC3\u9776\u70b9\u7684\u3001\u4f7f\u7528\u7ec6\u80de\u6cbb\u7597\u96be\u6cbb\u590d\u53d1\u809d\u764c\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u300213\u540dCAR-T\u6cbb\u7597\u7684\u60a3\u96be\u6cbb\u590d\u53d1\u7684\u809d\u7ec6\u80de\u764c\u60a3\u8005\u5747\u8010\u53d7\u826f\u597d\u3002<\/span><\/p>\n


<\/p>\n

\u968f\u540e\u5c06\u5f00\u5c55\u5168\u74031b\/2\u671f\u4e34\u5e8a\uff0c\u57285\u540d\u53ef\u8fdb\u884c\u7597\u6548\u8bc4\u4f30\u7684\u60a3\u8005\u4e2d\uff0c1\u540d\u60a3\u8005\u51fa\u73b0\u90e8\u5206\u7f13\u89e3,2\u540d\u75be\u75c5\u7a33\u5b9a\uff0c2\u540d\u60a3\u8005\u75be\u75c5\u8fdb\u5c55(\u4e00\u540d\u5728\u6cbb\u759712\u6708\u540e\u6b7b\u4ea1)\u3002<\/span><\/p>\n


<\/p>\n

4\u540d\u75c5\u4eba\u751f\u5b58\u671f\u5206\u522b\u8d85\u8fc714\u4e2a\u6708\u300120\u4e2a\u6708\u300114\u4e2a\u6708\u548c10\u4e2a\u6708\u30022017\u5e7412\u670828\u65e5\uff0cCAR-T-GPC3\u83b7\u5f97CFDA\u7684\u53d7\u7406\uff0c\u662f\u56fd\u5185\u9996\u4e2a\u7528\u4e8e\u5b9e\u4f53\u7624\u4e34\u5e8a\u8bd5\u9a8c\u7684CAR-T\u3002<\/span><\/p>\n


<\/p>\n

\u6b64\u5916\uff0c\u79d1\u6d4e\u751f\u7269\u8fd8\u5e03\u5c40\u9488\u5bf9\u80f6\u6bcd\u7ec6\u80de\u7624\u7684EGFR\/EGFRvIII\u53cc\u9776\u70b9CAR-T\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u9488\u5bf9\u80c3\u764c\u3001\u80f0\u817a\u764c\u7684Claudin18.2\u9776\u70b9\u6cbb\u7597\u7684CAR-T\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><\/p>\n


<\/p>\n

\u5c3d\u7ba1\u5f53\u524d\u8fd8\u6ca1\u6709\u5b9e\u4f53\u7624\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u8fdb\u5165\u5927\u89c4\u6a21\u4eba\u4f53\u8bd5\u9a8c\uff0c\u4f46\u6211\u4eec\u5bf9\u6280\u672f\u8fdb\u6b65\u6301\u6709\u4e50\u89c2\u6001\u5ea6\uff0c\u968f\u7740\u65b0\u578b\u9ad8\u7279\u5f02\u6027\u9776\u70b9\u7684\u53d1\u73b0\u53ca\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u7684\u5feb\u901f\u8fdb\u6b65\uff0c\u5b9e\u4f53\u7624\u653b\u514b\u5c06\u6210\u4e3a\u53ef\u80fd\u3002<\/span><\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
<\/section>\n
\n

\u7eb3\u5165\u533b\u4fdd\uff0c\u89e3\u51b3\u60a3\u8005\u6c89\u91cd\u8d1f\u62c5<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n

\u5c3d\u7ba1Kymriah\u548cYescarta\u5df2\u83b7\u51c6\u4e0a\u5e02\uff0c\u4f46\u7531\u4e8e\u9ad8\u6602\u7684\u6cbb\u7597\u8d39\u7528\u548c\u4e0d\u786e\u5b9a\u7684\u533b\u4fdd\u652f\u4ed8\u653f\u7b56\uff0c\u76ee\u524d\u5927\u91cf\u7f8e\u56fd\u60a3\u8005\u76ee\u524d\u6709\u5927\u91cf\u60a3\u8005\u5728\u6392\u961f\u7b49\u5f85\uff0c\u9664\u975e\u7b7e\u8ba2\u6587\u4ef6\u8868\u793a\u613f\u610f\u5728\u533b\u4fdd\u4e0d\u4e88\u652f\u4ed8\u65f6\u627f\u62c5\u5168\u90e8\u6cbb\u7597\u8d39\u7528\u3002<\/span><\/p>\n


<\/p>\n

\u6839\u636eBiopharmaDive\u4fe1\u606f\uff0c\u7f8e\u56fd\u533b\u7597\u4fdd\u9669\u5de8\u5934CMS\u57284\u6708\u521d\u5c06\u7ec6\u80de\u7597\u6cd5Kymriah\u3001Yescarta\u7eb3\u5165\u5176\u533b\u4fddB\u8ba1\u5212\uff0c\u5e76\u5c06\u5206\u522b\u652f\u4ed8\u4e0a\u965050\u4e07\u7f8e\u5143\u300140\u4e07\u7f8e\u5143\u3002\u6211\u4eec\u8ba4\u4e3aCMS\u505a\u6cd5\u7b26\u5408\u836f\u7269\u7ecf\u6d4e\u5b66\u903b\u8f91\uff0c\u539f\u56e0\u5982\u4e0b:<\/span><\/p>\n


<\/p>\n

1)Kymriah\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u6027\u767d\u8840\u75c5(ALL)\uff0c\u8be5\u75be\u75c5\u590d\u53d1\u60a3\u8005\u4e00\u822c\u9700\u8981\u5f02\u4f53\u9aa8\u9ad3\u79fb\u690d\u6cbb\u7597\uff0c\u8d39\u7528\u572850-80\u4e07\u7f8e\u5143\uff0c\u4e14\u540e\u7eed\u51e0\u5e74\u7ef4\u6301\u7528\u836f\u4ecd\u6709\u9ad8\u989d\u8d39\u7528;Yescarta\u7528\u4e8e\u6cbb\u7597\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff0c\u9700\u8981\u9020\u8840\u5e72\u7ec6\u80de\u79fb\u690d\u7684\u8d39\u7528\u4e5f\u572830\u4e07\u7f8e\u5143\u4ee5\u4e0a;<\/span><\/p>\n


<\/p>\n

2)Kymriah\u4e00\u6b21\u6cbb\u7597\u8d39\u752847.5\u4e07\u7f8e\u5143\uff0cYescarta\u4e00\u6b21\u6cbb\u7597\u8d39\u752837.5\u4e07\u7f8e\u5143\uff0c\u4e14\u6839\u636eKymriah\u6570\u636e\uff0c60%\u60a3\u8005\u5728\u81f3\u5c1114\u4e2a\u6708\u540e\u4ecd\u7ef4\u6301\u6cbb\u6108\u72b6\u6001\uff0c\u5373\u5177\u6709\u4e00\u6b21\u6cbb\u6108\u7684\u53ef\u80fd\uff0c\u957f\u671f\u770b\u6709\u4e00\u5b9a\u7ecf\u6d4e\u6027\u3002<\/span><\/p>\n


<\/p>\n

3)\u7ec6\u80de\u7597\u6cd5\u4ece\u5b9a\u4ef7\u4e0a\u57fa\u672c\u4e0e\u9aa8\u9ad3\u79fb\u690d\u53ef\u6bd4\uff0c\u8fdc\u671f\u8d39\u7528\u4e0a\u770b\uff0c\u751a\u81f3\u53ef\u80fd\u4f4e\u4e8e\u9aa8\u9ad3\u79fb\u690d\uff0c\u5047\u8bbe\u7ec6\u80de\u7597\u6cd5\u7684\u4f7f\u7528\u5f80\u524d\u63a8\u79fb\u66ff\u4ee3\u9aa8\u9ad3\u79fb\u690d\uff0c\u5219\u7ecf\u6d4e\u6027\u5c06\u66f4\u663e\u8457\u3002<\/span><\/p>\n


<\/p>\n

\u4e2d\u56fd\u9aa8\u9ad3\u79fb\u690d\u8d39\u7528\u4e00\u822c\u572820\u4e07\u5143\u5de6\u53f3\uff0c\u79fb\u6b96\u524d\u540e\u7528\u836f\u6210\u672c\u5927\u6982\u572830\u4e07\u5143\u5de6\u53f3\uff0c\u8003\u8651\u533b\u4fdd\u62a5\u9500\u540e\uff0c\u60a3\u8005\u81ea\u4ed8\u90e8\u5206\u7ea6\u4e3a10\u4e07\u5143\uff0c\u4f5c\u4e3a\u6709\u4e00\u6b21\u6027\u6cbb\u6108\u53ef\u80fd\u7684\u7597\u6cd5\uff0c\u7ec6\u80de\u6cbb\u7597\u5b9a\u4ef730-50\u4e07\u5e76\u4e0d\u7b97\u5f88\u8d35\uff0c\u6211\u4eec\u5bf9\u7ec6\u80de\u7597\u6cd5\u7eb3\u5165\u533b\u4fdd\u6301\u4e50\u89c2\u6001\u5ea6\u3002<\/span><\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
<\/section>\n
\n

\u964d\u4f4e\u7ec6\u80de\u7597\u6cd5\u751f\u4ea7\u6210\u672c<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n

T\u7ec6\u80de\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u901a\u8fc7\u4ece\u60a3\u8005\u6216\u8005\u6350\u732e\u8005\u5916\u5468\u8840\u5206\u79bb\u83b7\u5f97\u7279\u5b9a\u4e9a\u7fa4\u7684T\u7ec6\u80de\uff0c\u8fdb\u4e00\u6b65\u6fc0\u6d3b\u3001\u57fa\u56e0\u4fee\u9970\u83b7\u5f97CAR-T\u7ec6\u80de\uff0c\u6269\u589e\u57f9\u517b\u4ece\u800c\u5230\u8fbe\u6cbb\u7597\u7ea7\u522b\u7684\u7ec6\u80de\u6570\uff0c\u518d\u7ecf\u8fc7\u6d17\u6da4\u6d53\u7f29\u56de\u8f93\u60a3\u8005\u4f53\u5185\u8fdb\u884c\u6cbb\u7597\u3002<\/span><\/p>\n


<\/p>\n

CAR-T\u5236\u4f5c\u8fc7\u7a0b\u7684\u65e0\u83cc\u64cd\u4f5c\u3001\u7eaf\u5ea6\u3001\u5236\u5907\u7ed3\u679c\u7684\u5b89\u5168\u6027\u7b49\u8d28\u91cf\u63a7\u5236\u5bf9\u540e\u671f\u7684\u7597\u6548\u6709\u7740\u91cd\u8981\u5f71\u54cd\uff0c\u6240\u4ee5\u786e\u4fdd\u751f\u4ea7\u8fc7\u7a0b\u7684\u6807\u51c6\u5316\u548c\u81ea\u52a8\u5316\uff0c\u505a\u5230\u836f\u6548\u548c\u98ce\u9669\u53ef\u63a7\u662f\u9996\u8981\u4efb\u52a1\u3002<\/span><\/p>\n


<\/p>\n

\u4ece\u5206\u79bb\u6536\u96c6T\u7ec6\u80de\uff0c\u5230\u6fc0\u6d3b\u4fee\u9970\u518d\u5230\u6269\u589e\u7ec6\u80de\u3001\u56de\u8f93\u75c5\u4eba\u4f53\u5185\u662f\u590d\u6742\u7684\u6d41\u7a0b\uff0c\u4f20\u7edf\u4eba\u5de5\u5236\u5907\u9762\u4e34\u6781\u5927\u6311\u6218:<\/span><\/p>\n


<\/p>\n

\u7b2c\u4e00\u662f\u73af\u5883\u6311\u6218\uff0c\u5236\u5907\u8fc7\u7a0b\u6c61\u67d3\u7684\u53ef\u80fd\u6027\u5f88\u5927;<\/span><\/p>\n


<\/p>\n

\u7b2c\u4e8c\u662f\u4eba\u4e3a\u5dee\u5f02\uff0c\u6bcf\u4e2a\u64cd\u4f5c\u4eba\u5458\u7684\u504f\u597d\u4f1a\u5bfc\u81f4\u4ea7\u54c1\u53c2\u5dee\u4e0d\u9f50\uff0c\u4ea7\u751f\u5dee\u5f02\u6027;<\/span><\/p>\n


<\/p>\n

\u7b2c\u4e09\u662f\u4f5c\u4e3a\u9ad8\u5ea6\u4e2a\u6027\u5316\u4ea7\u54c1\uff0c\u6bcf\u4e2a\u60a3\u8005\u5373\u4e00\u4e2a\u751f\u4ea7\u6279\u6b21\uff0c\u4e0e\u4f20\u7edf\u5236\u836f\u5de5\u827a\u6709\u8f83\u5927\u5dee\u5f02;<\/span><\/p>\n


<\/p>\n

\u7b2c\u56db\uff0c\u8840\u6db2\u80bf\u7624\u60a3\u8005\u75c5\u60c5\u8fdb\u5c55\u6781\u5feb\uff0c\u9700\u8981\u5c3d\u91cf\u7f29\u77ed\u5236\u5907\u65f6\u95f4\u53ca\u65f6\u56de\u8f93\uff0c\u5e76\u63d0\u9ad8\u6210\u529f\u7387\u3002<\/span><\/p>\n


<\/p>\n

\u56e0\u6b64\uff0cCAR-T\u751f\u4ea7\u8fc7\u7a0b\u7684\u6807\u51c6\u5316\u3001\u81ea\u52a8\u5316\u4ee5\u53ca\u5b89\u5168\u6027\u3001\u65e0\u83cc\u6027\u3001\u7eaf\u5ea6\u7b49\u8d28\u91cf\u63a7\u5236\u662f\u5ba2\u89c2\u8bc4\u4ef7\u7f13\u89e3\u7387\u7684\u5148\u51b3\u6761\u4ef6\u3002<\/span><\/p>\n


<\/p>\n

\"\u56fd\u9645\u5de8\u5934\u91cd\u91d1\u52a0\u7801\u7ec6\u80de\u6cbb\u7597\uff0c\u5546\u4e1a\u5316\u8fdb\u7a0b\u6709\u671b\u8d85\u9884\u671f\"<\/p>\n

\"\u56fd\u9645\u5de8\u5934\u91cd\u91d1\u52a0\u7801\u7ec6\u80de\u6cbb\u7597\uff0c\u5546\u4e1a\u5316\u8fdb\u7a0b\u6709\u671b\u8d85\u9884\u671f\"<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
<\/section>\n
\n


<\/p>\n

\u5316\u89e3\u9ad8\u6210\u672c\u538b\u529b:<\/strong><\/span><\/p>\n

\u4ece\u81ea\u52a8\u5316\u548c\u6162\u75c5\u6bd2\u5f00\u59cb<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n

CAR-T\u751f\u4ea7\u6210\u672c\u9ad8\u8fbe30\u4e07\u7f8e\u5143\uff0c\u5176\u539f\u56e0\u5728\u4e8e\u4e09\u70b9:<\/span><\/p>\n


<\/p>\n

CAR-T\u4f5c\u4e3a\u9ad8\u5ea6\u4e2a\u6027\u5316\u7684\u836f\u54c1\uff0c\u4e00\u4e2a\u60a3\u8005\u5bf9\u5e94\u4e00\u4e2a\u6279\u6b21\uff0c\u5236\u5907\u64cd\u4f5c\u9700\u8981\u591a\u540d\u9ad8\u7aef\u6280\u672f\u4eba\u5458\u8fdb\u884c\u65e0\u83cc\u7cbe\u51c6\u64cd\u4f5c\uff0c\u4eba\u529b\u6210\u672c\u6781\u9ad8;<\/span><\/p>\n


<\/p>\n

\u4e3a\u4e86\u4fdd\u8bc1\u6d01\u51c0\u5ea6\u3001\u7eaf\u5ea6\u548c\u5236\u5907\u7ed3\u679c\u7684\u5b89\u5168\u6027\uff0c\u9700\u8981\u5efa\u8bbe\u5927\u9762\u79ef\u4e13\u4e1a\u5316\u65e0\u83cc\u64cd\u4f5c\u533a\u95f4\uff0c\u4e13\u4e1a\u5316\u7684\u6e05\u6d01\u4eba\u5458\u9700\u8981\u5b9a\u671f\u8fdb\u884c\u7ef4\u62a4\uff0c\u8fd0\u8425\u6210\u672c\u6781\u9ad8;<\/span><\/p>\n


<\/p>\n

\u8f6c\u67d3CAR\u4f7f\u7528\u7684\u6162\u75c5\u6bd2\u7684\u7a33\u5b9a\u6027\u548c\u5b89\u5168\u6027\u5bf9CAR-T\u4ea7\u54c1\u5236\u5907\u7684\u8d28\u91cf\u548c\u4f7f\u7528\u5b89\u5168\u6027\u5f71\u54cd\u5f88\u5927\uff0c\u4f18\u8d28\u7684\u6162\u75c5\u6bd2\u91c7\u8d2d\u6210\u672c\u9ad8\u8fbe5-10\u4e07\u5143\uff0c\u800c\u81ea\u5236\u6162\u75c5\u6bd2\u53c8\u96be\u4ee5\u89e3\u51b3\u7a33\u5b9a\u6027\u7684\u95ee\u9898\u3002<\/span><\/p>\n


<\/p>\n

\u8bfa\u534e\u65d7\u4e0bCarlJune\u56e2\u961f\u7684CTL-019\u7597\u6cd5\u4e2d\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u7684\u4e34\u5e8a\u7ec6\u80de\u548c\u75ab\u82d7\u751f\u4ea7\u4e2d\u5fc3(Clinicalcellandvaccineproductionfacility)\uff0c\u7b26\u5408FDA-GMP\u6807\u51c6\uff0c\u6240\u6709GMP\u8f66\u95f4\u90fd\u662f\u7531\u53d7\u8fc7\u4e13\u4e1a\u57f9\u8bad\u7684\u64cd\u4f5c\u4eba\u5458\u6309\u7167\u65e2\u5b9a\u7a0b\u5e8f\uff0c\u5404\u79cd\u5173\u952e\u8bbe\u5907\u4e25\u683c\u7ba1\u63a7\uff0c\u5b9e\u73b0\u6574\u4e2a\u751f\u4ea7\u8fc7\u7a0b\u7684\u6c61\u67d3\u9632\u6b62\u3002<\/span><\/p>\n


<\/p>\n

\u968f\u7740\u66f4\u591aCAR-T\u4ea7\u54c1\u4e0a\u5e02\uff0c\u672a\u6765\u6709\u66f4\u591a\u75c5\u4eba\u4ece\u4e2d\u53d7\u76ca\uff0c\u9762\u5bf9\u5982\u6b64\u5e9e\u5927\u7684\u5e02\u573a\u9700\u6c42\uff0cCAR-T\u7ec6\u80de\u5236\u5907\u8fc7\u7a0b\u7684\u5168\u81ea\u52a8\u5316\u3001\u6807\u51c6\u5316\u5c06\u662f\u5404\u5927\u7ec6\u80de\u6cbb\u7597\u516c\u53f8\u91cd\u70b9\u5173\u6ce8\u7684\u9886\u57df\u3002
<\/span><\/p>\n


<\/p>\n

\"\u56fd\u9645\u5de8\u5934\u91cd\u91d1\u52a0\u7801\u7ec6\u80de\u6cbb\u7597\uff0c\u5546\u4e1a\u5316\u8fdb\u7a0b\u6709\u671b\u8d85\u9884\u671f\"<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
<\/section>\n
\n

\u81ea\u52a8\u5316\u8bbe\u5907\u7684\u4f7f\u7528\u6709\u5229\u4e8e\u964d\u4f4e\u6210\u672c<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n

\u591a\u5bb6CAR-T\u7814\u53d1\u4f01\u4e1a\u5df2\u7ecf\u5f62\u6210\u81ea\u5df1\u7684\u5de5\u827a\u6d41\u7a0b\uff0c\u5176\u4e2d\u6700\u4e3a\u6210\u719f\u7684\u662f\u5fb7\u56fdMiltenyi\u516c\u53f8\u7684\u5168\u81ea\u52a8\u5e73\u53f0CliniMACSProdigy\uff0c\u5b9e\u73b0\u75c5\u4eba\u8840\u6db2\u7ec6\u80de\u7684\u5206\u9009\uff0c\u8f6c\u67d3\uff0c\u6269\u589e\u81ea\u52a8\u5316\uff0c\u907f\u514d\u751f\u4ea7\u8fc7\u7a0b\u4e2d\u591a\u4e2a\u8bbe\u5907\u4e4b\u95f4\u5207\u6362\u9020\u6210\u7684\u4eba\u5458\u6210\u672c\u548c\u6c61\u67d3\u98ce\u9669\u3002<\/span><\/p>\n


<\/p>\n

CliniMACSProdigy\u662f\u76ee\u524d\u5168\u7403\u552f\u4e00\u7684CAR-T\u5168\u81ea\u52a8\u5316\u5236\u5907\u4ea7\u54c1\uff0c\u5bc6\u95ed\u5b89\u5168\u3001\u81ea\u52a8\u65b9\u4fbf\u3001\u7528\u6237\u53cb\u597d\uff0c\u4e0d\u53d7\u57fa\u7840\u8bbe\u65bd\u7684\u9650\u5236\uff0c\u6613\u4e8e\u6269\u5927CAR-T\u7ec6\u80de\u5236\u5907\u7684\u9002\u7528\u8303\u56f4;\u800c\u4e14\u5168\u81ea\u52a8\u63d0\u53d6\uff0c\u6279\u6b21\u7a33\u5b9a\u6027\u6709\u6548\u6027\u5f88\u597d\uff0c\u8fdc\u8fdc\u8d85\u8fc7\u624b\u5de5\u5236\u4f5c\u3002<\/span><\/p>\n


<\/p>\n

\"\u56fd\u9645\u5de8\u5934\u91cd\u91d1\u52a0\u7801\u7ec6\u80de\u6cbb\u7597\uff0c\u5546\u4e1a\u5316\u8fdb\u7a0b\u6709\u671b\u8d85\u9884\u671f\"<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u6162\u75c5\u6bd2\u8f7d\u4f53\u7684\u672c\u571f\u5316<\/strong><\/span><\/p>\n

\u6709\u671b\u8fdb\u4e00\u6b65\u964d\u4f4e\u6210\u672c<\/strong><\/span><\/p>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n

\u6162\u75c5\u6bd2\u8f7d\u4f53\u662fCAR-T\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u751f\u4ea7\u7684\u5173\u952e\u539f\u6599\uff0c\u5bf9\u4ea7\u54c1\u6700\u7ec8\u8d28\u91cf\u6709\u7740\u81f3\u5173\u91cd\u8981\u7684\u5f71\u54cd\u3002\u6162\u75c5\u6bd2\u5236\u5907\u8fc7\u7a0b\u590d\u6742(\u56fe\u886819)\uff0c\u4e00\u822c\u81f3\u5c11\u9700\u8981\u4e24\u5468\u65f6\u95f4\uff0c\u800c\u4e14\u9700\u8981\u5728\u8d85\u51c0\u73af\u5883\u4e0b\uff0c\u5e76\u5728\u7b26\u5408GMP\u6807\u51c6\u7684\u73af\u5883\u4e0b\u751f\u4ea7\uff0c\u56e0\u6b64\u6210\u672c\u8f83\u9ad8\u3002\u7406\u60f3\u7684\u6162\u75c5\u6bd2\u8f7d\u4f53\u5e94\u5f53\u5177\u6709\u7a33\u5b9a\u6027\u548c\u5b89\u5168\u6027\u3002\u7a33\u5b9a\u6027\u662f\u6307\u4fdd\u8bc1\u5728\u4e0d\u540c\u5730\u70b9\uff0c\u4e0d\u540c\u60a3\u8005\u6279\u6b21CAR-T\u7ec6\u80de\u751f\u4ea7\u4e2d\uff0c\u83b7\u5f97\u76f8\u5bf9\u4e00\u81f4\u7684\u6548\u679c\u3002\u5b89\u5168\u6027\u5219\u9700\u8981\u6cbb\u7597\u540e\u60a3\u8005\u7684\u957f\u671f\u968f\u8bbf\u8ddf\u8e2a\u3002<\/span><\/span><\/p>\n


<\/span><\/p>\n

\u8003\u8651\u5230\u7a33\u5b9a\u6027\u548c\u5b89\u5168\u6027\u7684\u9ad8\u8981\u6c42\uff0c\u8bfa\u534e\u7684CTL019\uff0cKymriah\u9009\u62e9OxfordBiomedica\u516c\u53f8\u4f5c\u4e3a\u6162\u75c5\u6bd2\u8f7d\u4f53\u552f\u4e00\u4f9b\u5e94\u5546\uff0c\u7b7e\u8ba23-5\u5e74\u7684\u4f9b\u5e94\u5408\u540c\uff0c\u9884\u8ba13\u5e74\u5185OxfordBiomedica\u5bf9\u8bfa\u534e\u9500\u552e1\u4ebf\u7f8e\u5143\uff0c\u9884\u8ba1\u7ec6\u80de\u6cbb\u7597\u7528\u6162\u75c5\u6bd2\u5e02\u573a\u572810\u4ebf\u7f8e\u5143\u4ee5\u4e0a\u3002<\/span><\/p>\n


<\/p>\n

OxfordBioMedica\u662f\u4e00\u5bb6\u6162\u75c5\u6bd2\u8f7d\u4f53\u9886\u57df\u7684\u9f99\u5934\u516c\u53f8\uff0c\u62e5\u6709\u4e30\u5bcc\u7684\u80bf\u7624\u3001\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u3001\u773c\u79d1\u76f8\u5173\u7684\u57fa\u56e0\u548c\u7ec6\u80de\u6cbb\u7597\u7ba1\u7ebf\uff0c\u5e76\u4e0e\u8bfa\u534e\u3001\u8d5b\u8bfa\u83f2\u3001GSK\u7b49\u4e00\u7ebf\u836f\u4f01\u5efa\u7acb\u4e86\u826f\u597d\u5408\u4f5c\u5173\u7cfb\u3002<\/span><\/p>\n


<\/p>\n

2017\u5e744\u6708\uff0c\u590d\u661f\u533b\u836f\u548c\u7f8e\u56fdKite\u5171\u540c\u8bbe\u7acb\u7684\u5408\u8425\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u5728\u4e2d\u56fd\u5546\u4e1a\u5316\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u3002<\/span><\/p>\n


<\/p>\n

2017\u5e7412\u6708\uff0c\u5f3a\u751f\u65d7\u4e0b\u6768\u68ee\u5236\u836f\u4e0e\u91d1\u65af\u745e\u751f\u7269\u79d1\u6280\u7b7e\u7f72\u4e86\u5173\u4e8e\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u9886\u57df\u7684\u82e5\u5e72\u4ea7\u54c1\u7684\u5f00\u53d1\u3001\u5236\u9020\u548c\u5546\u4e1a\u5316\u7684\u7279\u8bb8\u534f\u8bae\uff0c\u6768\u68ee\u516c\u53f8\u5c06\u5e2e\u52a9\u91d1\u65af\u745e\u5efa\u9020\u7ec6\u80de\u6cbb\u7597\u751f\u4ea7\u8bbe\u65bd\u3002<\/span><\/p>\n


<\/p>\n

2018\u5e741\u6708\uff0c\u535a\u751f\u5409\u5b89\u79d1\u4e0e\u5fb7\u56fdMiltenyi\u516c\u53f8\u8fbe\u6210\u5408\u4f5c\u5907\u5fd8\u5f55\uff0c\u5728\u5408\u80a5\u5efa\u8bbe\u57fa\u4e8eCliniMACSProdigy\u548cMACSQuant\u5e73\u53f0\u7684\u5168\u81ea\u52a8CAR-T\u7ec6\u80de\u5236\u5907\u5de5\u5382\uff0c\u81f4\u529b\u4e8eCAR-T\u7597\u6cd5\u5404\u4e2a\u9886\u57df\u5c55\u5f00\u6df1\u5ea6\u5408\u4f5c\u3002<\/span><\/p>\n


<\/p>\n

\u836f\u660e\u5eb7\u5fb7\u5728\u7f8e\u56fd\u5efa\u7acb\u7684\u5b50\u516c\u53f8AppTec(\u836f\u660e\u5eb7\u5fb7\u7f8e\u56fd)\u9488\u5bf9CAR-T\u7ec6\u80de\u7597\u6cd5\u5f00\u5c55\u4ee5\u4e0b\u670d\u52a1:1)\u751f\u4ea7\u5de5\u827a\u7814\u7a76\uff0c\u5305\u62ec\u5de5\u827a\u4f18\u5316\u3001\u5e73\u53f0\u53d1\u5c55\u3001\u5de5\u827a\u653e\u5927\u4e0e\u5de5\u827a\u9a8c\u8bc1;2)\u9762\u5411\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7ec6\u80de\u6cbb\u7597\u548c\u57fa\u56e0\u6cbb\u7597\u4ea7\u54c1\u7684\u5c0f\u6279\u91cf\u751f\u4ea7;3)\u7ec6\u80de\u6cbb\u7597\u548c\u57fa\u56e0\u6cbb\u7597\u4ea7\u54c1\u7684\u5546\u4e1a\u5316\u751f\u4ea7;4)\u76f8\u5173\u6d4b\u8bd5\u670d\u52a1\u3002<\/span><\/p>\n


<\/p>\n

\u9664\u6b64\u4e4b\u5916\uff0c\u4ee5\u5409\u51ef\u57fa\u56e0\u3001\u548c\u5143\u4e0a\u6d77\u3001\u4e0a\u6d77\u590d\u767e\u5965\u4e3a\u4ee3\u8868\u7684\u6211\u56fd\u6162\u75c5\u6bd2\u4f9b\u5e94\u5546\u6b63\u5728\u5d1b\u8d77\uff0c\u4e3a\u6211\u56fd\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u63d0\u4f9b\u4f18\u8d28\u4f4e\u4ef7\u7684\u6162\u75c5\u6bd2\u8f7d\u4f53\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n


<\/p>\n

\u964d\u4f4e\u6210\u672c\u7684\u7ec8\u6781\u6b66\u5668:<\/strong><\/span><\/p>\n

\u4ece\u4e2a\u6027\u5316\u5230\u901a\u7528\u578b<\/strong><\/span><\/p>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n

\u81ea\u4f53CAR-T\u7ec6\u80de\u6cbb\u7597\u662f\u4e00\u79cd\u4e2a\u6027\u5316\u7684\u6cbb\u7597\u65b9\u5f0f\uff0c\u751f\u4ea7\u6210\u672c\u6781\u9ad8\uff0c\u4e14\u7531\u4e8e\u60a3\u8005\u75be\u75c5\u8fdb\u5c55\u8f83\u5feb\uff0c\u81ea\u4f53CAR-T\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u751f\u4ea7\u5468\u671f\u8f83\u957f\uff0c\u53e6\u5916\uff0c\u5bf9\u4e8e\u5a74\u5e7c\u513f\u60a3\u8005\u3001\u8001\u9f84\u60a3\u8005\u4ee5\u53ca\u5316\u7597\u3001\u653e\u7597\u540e\u7684\u75c5\u4eba\uff0c\u4f53\u5185T\u7ec6\u80de\u7684\u6570\u91cf\u548c\u8d28\u91cf\u90fd\u4e0d\u80fd\u8fbe\u5230CAR-T\u6cbb\u7597\u7684\u8981\u6c42\uff0c\u90e8\u5206\u60a3\u8005\u96be\u4ee5\u53ca\u65f6\u56de\u8f93\u6cbb\u7597\uff0c\u5931\u53bb\u5ef6\u957f\u751f\u547d\u7684\u673a\u4f1a\u3002<\/span><\/p>\n


<\/p>\n

\u901a\u7528\u578bCAR-T\u7684\u5f00\u53d1\u6392\u9664\u4e2a\u4f53\u5dee\u5f02\uff0c\u5b9e\u73b0\u89c4\u6a21\u5316\u751f\u4ea7\uff0c\u4ece\u800c\u964d\u4f4e\u6210\u672c\uff0c\u964d\u4f4e\u6cbb\u7597\u8d39\u7528\uff0c\u7f29\u77ed\u56de\u8f93\u65f6\u95f4\u3002\u8bfa\u534e\u4e34\u5e8a\u6570\u636e\u663e\u793a\uff0c\u81ea\u4f53CART\u5236\u5907\u7684\u5931\u8d25\u7387\u662f10%\uff0c\u56e0\u6b64\u5f02\u4f53CAR-T\u6cbb\u7597\u65e0\u7591\u5bf9\u8fd9\u90e8\u5206\u75c5\u4eba\u4ee5\u53ca\u672a\u6765\u7684\u89c4\u6a21\u5316\u91cf\u4ea7\u7531\u5f88\u5927\u7684\u73b0\u5b9e\u610f\u4e49\u3002<\/span><\/p>\n

\"\u56fd\u9645\u5de8\u5934\u91cd\u91d1\u52a0\u7801\u7ec6\u80de\u6cbb\u7597\uff0c\u5546\u4e1a\u5316\u8fdb\u7a0b\u6709\u671b\u8d85\u9884\u671f\"<\/p>\n

\"\u56fd\u9645\u5de8\u5934\u91cd\u91d1\u52a0\u7801\u7ec6\u80de\u6cbb\u7597\uff0c\u5546\u4e1a\u5316\u8fdb\u7a0b\u6709\u671b\u8d85\u9884\u671f\"<\/p>\n


<\/p>\n

\u6211\u4eec\u8ba4\u4e3a\u6839\u636e\u73b0\u884c\u7684\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u5b89\u5168\u6027\u8bc4\u4ef7\u529e\u6cd5\uff0c\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u5b89\u5168\u6027\u8bc4\u4ef7\u5e02\u573a\u7a7a\u95f4\u4e2d\u6027\u6d4b\u7b97\u5728 7 \u4ebf\u5143 \u5de6\u53f3\uff0c\u4e50\u89c2\u6d4b\u7b97\u5047\u8bbe\u4e3a\u5c0f\u9f20\u5b89\u8bc4\u6bcf\u5e74 80 \u4e2a\uff0c\u5747\u4ef7 600 \u4e07\u5143\uff0c\u98df\u87f9\u7334\u5b89\u8bc4\u6bcf\u5e74 80 \u4e2a\uff0c\u5747\u4ef7 800 \u4e07\uff0c\u5bf9\u5e94\u5e02\u573a\u7a7a \u95f4 10.2 \u4ebf\u5143;\u4e2d\u6027\u5047\u8bbe\u4e3a\u5c0f\u9f20\u5b89\u8bc4\u6bcf\u5e74 50 \u4e2a\uff0c\u5747\u4ef7 600 \u4e07\u5143\uff0c\u98df\u87f9\u7334\u5b89\u8bc4\u6bcf\u5e74 50 \u4e2a\uff0c\u5747\u4ef7 800 \u4e07\u5143\uff0c\u5e02\u573a\u7a7a \u95f4\u4e3a 7 \u4ebf\u5143;\u4fdd\u5b88\u6d4b\u7b97\u5047\u8bbe\u4e3a\u5c0f\u9f20\u5b89\u8bc4\u6bcf\u5e74 30 \u4e2a\uff0c\u5747\u4ef7 600 \u4e07\u5143\uff0c\u98df\u87f9\u7334\u5b89\u8bc4\u6bcf\u5e74 30 \u4e2a\uff0c\u5747\u4ef7 800 \u4e07\u5143\uff0c\u5e02 \u573a\u7a7a\u95f4\u4e3a 4.2 \u4ebf\u5143\u3002<\/span><\/p>\n


<\/p>\n

\u76ee\u524d\u836f\u7269\u5b89\u5168\u6027\u8bc4\u4ef7\u5e02\u573a\u7ea6 10 \u4ebf\u5143\uff0c\u7ec6\u80de\u7597\u6cd5\u7814\u53d1\u7684\u7e41\u8363\u7ed9\u836f\u7269\u5b89\u5168\u6027\u8bc4\u4ef7\u5e26\u6765\u7684\u5f39\u6027\u5de8\u5927\u3002\u6211\u4eec\u9884\u8ba1\uff0c\u968f\u7740\u65b0\u9776\u70b9\u7684\u6301\u7eed\u5f00\u53d1\uff0c\u5b9e\u4f53\u7624\u7ec6\u80de\u7597\u6cd5\u7684\u7814\u53d1\u70ed\u60c5\u8fdb\u4e00\u6b65\u63d0\u9ad8\uff0c\u7ec6\u80de\u6cbb\u7597\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6570\u91cf\u4f1a \u6301\u7eed\u589e\u957f\u3002<\/span><\/p>\n


<\/p>\n

\"\u56fd\u9645\u5de8\u5934\u91cd\u91d1\u52a0\u7801\u7ec6\u80de\u6cbb\u7597\uff0c\u5546\u4e1a\u5316\u8fdb\u7a0b\u6709\u671b\u8d85\u9884\u671f\"<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
<\/section>\n
\n

\u9884\u671f\u5dee\u4e4b\u4e8c:\u5546\u4e1a\u5316\u8fdb\u7a0b\u6709\u671b\u8d85\u9884\u671f<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u6211\u56fd\u79d1\u7814\u6c34\u5e73\u53ca\u79d1\u7814\u4e34\u5e8a\u6570<\/strong><\/span><\/p>\n

\u5904\u4e8e\u7b2c\u4e00\u68af\u961f<\/strong><\/span><\/p>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n

2017\u5e7412\u6708\u5357\u4eac\u4f20\u5947\u751f\u7269\u7684CAR-T\u4ea7\u54c1\u9996\u5bb6\u83b7\u5f97CDE\u53d7\u7406\u5e76\u8fdb\u5165\u4f18\u5148\u5ba1\u8bc4\u901a\u9053\uff0c\u622a\u81f3\u76ee\u524dCDE\u53d7\u7406CAR-T\u7533\u62a5\u6570\u91cf\u589e\u81f312\u4e2a\uff0c\u5176\u4e2d4\u4e2a\u4ea7\u54c1\u8fdb\u5165\u4f18\u5148\u5ba1\u8bc4\u3002<\/span><\/p>\n


<\/p>\n

2018\u5e741\u670829\u65e5\uff0cCDE\u62df\u5c062017\u5e74\u7533\u62a5\u7684\u53e6\u5916\u4e09\u4e2aCAR-T\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u901a\u9053\uff0c\u53cd\u6620\u51faCFDA\u5bf9\u52a0\u5febCAR-T\u7597\u6cd5\u5ba1\u8bc4\u7684\u79ef\u6781\u6001\u5ea6\u3002<\/span><\/p>\n


<\/p>\n

\u9884\u8ba1CAR-T\u7597\u6cd5\u7533\u62a5\u5747\u5177\u6709\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u8d44\u683c\u30022018\u5e743\u670813\u65e5\uff0c\u5357\u4eac\u4f20\u5947LCAR-B38MCAR-T\u7ec6\u80de\u81ea\u4f53\u56de\u8f93\u5236\u5242\u6536\u5230CFDA\u7684\u4e34\u5e8a\u6279\u4ef6\uff0c\u6210\u4e3a\u56fd\u5185\u9996\u4e2a\u83b7\u5f97\u4e34\u5e8a\u6279\u4ef6\u7684\u516c\u53f8\u3002<\/span><\/p>\n


<\/p>\n

\u4ece\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\u6570\u6765\u770b\uff0c\u4e2d\u56fd\u73b0\u5728\u662f\u5168\u7403\u6700\u6d3b\u8dc3\u7684CAR-T\u4e34\u5e8a\u8bd5\u9a8c\u56fd\u5bb6\uff0c\u6570\u91cf\u8d85\u8fc7\u5317\u7f8e\uff0c\u4e14\u8fdc\u8d85\u6b27\u6d32\u3001\u65e5\u672c\u7b49\u5730\u3002<\/span><\/p>\n


<\/p>\n

\"\u56fd\u9645\u5de8\u5934\u91cd\u91d1\u52a0\u7801\u7ec6\u80de\u6cbb\u7597\uff0c\u5546\u4e1a\u5316\u8fdb\u7a0b\u6709\u671b\u8d85\u9884\u671f\"<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u56fd\u5185\u653f\u7b56\u660e\u6717\uff0c\u836f\u5ba1\u6548\u7387\u63d0\u5347<\/strong><\/span><\/p>\n

\u4e3aCAR-T\u53d1\u5c55\u9526\u4e0a\u6dfb\u82b1\u3002<\/strong><\/span><\/p>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n

\u4e0d\u540c\u4e8e\u4f20\u7edf\u7684\u836f\u7269\uff0cCAR-T\u662f\u6d3b\u4f53\u7ec6\u80de\uff0c\u9700\u8981\u5728\u7279\u5b9a\u573a\u6240\u5b9e\u65bd\u6cbb\u7406;\u53e6\u4e00\u65b9\u9762\uff0cCAR-T\u63a5\u53d7\u57fa\u56e0\u5de5\u7a0b\u6539\u9020\uff0c\u4e5f\u5c5e\u4e8e\u57fa\u56e0\u6cbb\u7597\u836f\u7269\u3002<\/span><\/p>\n


<\/p>\n

\u57fa\u4e8eCAR-T\u7279\u6b8a\u6027\uff0c\u5982\u4f55\u8fdb\u884c\u76d1\u7ba1\u6210\u4e3a\u4e00\u4e2a\u96be\u70b9\uff0c\u56fd\u5bb6\u653f\u7b56\u7684\u5927\u529b\u652f\u6301\uff0c\u4f7f\u5f97CAR-T\u76d1\u7ba1\u660e\u6717\u5316\uff0c\u836f\u5ba1\u90e8\u95e8\u660e\u786eCAR-T\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\uff0c\u4e3aCAR-T\u52a0\u901f\u4e0a\u5e02\u63d0\u4f9b\u52a9\u529b\u3002<\/span><\/p>\n


<\/p>\n

\u81ea2016\u5e7412\u670816\u65e5\uff0c\u53d1\u5e03\u300a\u7ec6\u80de\u5236\u54c1\u7814\u7a76\u4e0e\u8bc4\u4ef7\u6280\u672f\u6307\u5bfc\u539f\u5219\u300b(\u5f81\u6c42\u610f\u89c1\u7a3f)\u4ee5\u6765\uff0c\u7ec6\u80de\u6cbb\u7597\u653f\u7b56\u843d\u5730\u53cd\u6620\u56fd\u5bb6\u5bf9\u533b\u7597\u521b\u65b0\u6280\u672f\u7684\u9ad8\u5ea6\u652f\u6301\u548c\u9f13\u52b1\uff0c\u5c06\u76f4\u63a5\u5229\u597d\u7ec6\u80de\u6cbb\u7597\u6280\u672f\u516c\u53f8\u30022017\u5e7412\u6708CFDA\u53d1\u5e03\u4e86\u300a\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u7814\u7a76\u4e0e\u8bc4\u4ef7\u6280\u672f\u6307\u5bfc\u539f\u5219(\u8bd5\u884c)\u300b\uff0c\u56fd\u5bb6\u5c42\u9762\u653f\u7b56\u9010\u6e10\u660e\u6717\uff0c\u9884\u8ba12018\u5e74\u5c06\u7ee7\u7eed\u6709\u591a\u5bb6\u751f\u7269\u6280\u672f\u516c\u53f8\u63d0\u51fa\u7ec6\u80de\u6cbb\u7597\u6280\u672f\u4e34\u5e8a\u7814\u7a76\u7533\u8bf7\uff0c\u4ea7\u4e1a\u6295\u8d44\u70ed\u6f6e\u5373\u5c06\u6765\u4e34\uff0c2018\u5e74\u6709\u671b\u6210\u4e3aCAR-T\u6295\u8d44\u5927\u5e74\u3002<\/strong><\/span><\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
<\/section>\n
\n

\u4e2d\u7f8e\u7ec6\u80de\u7597\u6cd5\u79d1\u7814\u5b9e\u529b\u76f8\u8fd1<\/strong><\/span><\/p>\n

\u6211\u56fd\u6709\u671b\u8dd1\u51fa\u5168\u7403\u6838\u5fc3\u8d44\u4ea7<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n

\u4ece\u8bd5\u9a8c\u9776\u70b9\u53ca\u9002\u5e94\u75c7\u4e0a\u770b\uff0c\u6211\u56fd\u4e34\u5e8a\u9776\u70b9\u79cd\u7c7b\u53ca\u9002\u5e94\u75c7\u4e5f\u662f\u7d27\u8ddf\u7f8e\u56fd\uff0c\u4e8c\u8005\u79d1\u7814\u4e34\u5e8a\u6c34\u5e73\u4e0d\u76f8\u4f2f\u4ef2\u3002<\/span><\/p>\n


<\/p>\n

\u4ece\u6211\u56fd\u5728ClinicalTrials.gov\u4e0a\u767b\u8bb0\u7684\u4e34\u5e8a\u8bd5\u9a8c\u770b\uff0c\u76ee\u524d\u5df2\u8986\u76d643\u4e2a\u9776\u70b9\u6216\u9776\u70b9\u7ec4\u5408\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u7f8e\u56fd\u8986\u76d6\u5927\u7ea620\u4e2a\u9776\u70b9\u6216\u9776\u70b9\u7ec4\u5408\u3002CD19\u3001CD22\u3001BCMA\u5728\u4e2d\u7f8e\u4e24\u56fd\u5747\u4e3a\u6700\u70ed\u9776\u70b9\uff0c\u4e24\u56fd\u90fd\u5728EGFRvIII\u3001MSLN\u3001CEA\u7b49\u65b0\u5174\u9776\u70b9\u4e0a\u6709\u8bd5\u9a8c\uff0c\u4e24\u56fd\u5747\u6709\u901a\u7528\u578bCAR-T\u6ce8\u518c\u8bd5\u9a8c\u3002<\/span><\/p>\n


<\/p>\n

\u4e0d\u540c\u4e4b\u5904\u5728\u4e8e\u7f8e\u56fd\u7684\u9776\u70b9\u521b\u65b0\u66f4\u591a\u662f\u57fa\u4e8e\u5df2\u6709\u7684\u6210\u719f\u9776\u70b9\u5ac1\u63a5\u4e8eCAR-T\uff0c\u4f8b\u5982VEGFR\u3001HER2\u3001C-Met\uff0c\u4e2d\u56fd\u7684\u521b\u65b0\u4fa7\u91cd\u4e8e\u91cd\u65b0\u7ec4\u5408(CD19-22\uff0cCD19-PD1\u7b49)\u548c\u5168\u65b0\u9776\u70b9(CD80\u3001CD86\u3001CD56\u3001CD117\u7b49)\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n


<\/p>\n

\u5177\u4f53\u770b\u6700\u70ed\u7684<\/strong><\/span><\/p>\n

\u4e09\u4e2a\u9776\u70b9CD19\u3001CD22\u3001BCMA:<\/strong><\/span><\/p>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n

1)CD19\u975e\u5e38\u6210\u719f\uff0c\u7f8e\u56fd\u5df2\u6709\u4e24\u4e2a\u4e0a\u5e02\u54c1\u79cd\uff0c\u6211\u56fd\u5df2\u670950\u4e2a\u6ce8\u518c\u4e34\u5e8a\uff0c9\u4e2a\u54c1\u79cd\u7533\u62a5IND\uff0c\u7531\u4e8eCD19\u786e\u5b9a\u6027\u9ad8\uff0c\u8fd9\u4e00\u9886\u57df\u5dee\u8ddd\u53ea\u662f\u65f6\u95f4\u95ee\u9898;<\/span><\/p>\n


<\/p>\n

2)CD22\u7f8e\u56fd\u4e34\u5e8a\u65707\u4e2a\uff0c\u6211\u56fd8\u4e2a\uff0c\u4f5c\u4e3a\u6865\u63a5CD19-CAR-T\u7684\u54c1\u79cd\uff0c\u6211\u56fd\u5e76\u4e0d\u843d\u540e;<\/span><\/p>\n


<\/p>\n

3)BCMA\u9776\u70b9\u88ab\u8a89\u4e3a\u201c\u4e0b\u4e00\u4e2a\u6700\u5177\u6210\u836f\u6027\u201d\u7684\u9776\u70b9\uff0c\u7f8e\u56fd\u4e3b\u8981\u662fBluebird\u516c\u53f8\u5728\u63a8\u8fdb\uff0cKITE2017\u5e74\u4e0b\u534a\u5e74\u542f\u52a8\u4e34\u5e8a\u8bd5\u9a8c\uff0cJUNO\u4e34\u5e8a\u8bd5\u9a8c\u5904\u4e8e\u4e34\u5e8aI\u671f\u62db\u52df\u72b6\u6001\uff0c\u6211\u56fd\u5357\u4eac\u4f20\u5947\u516c\u53f8(\u91d1\u65af\u745e\u751f\u7269\u79d1\u6280)\u5df2\u8fdb\u884c\u63a5\u8fd1\u4e24\u5e74\u65f6\u95f4\u79d1\u7814\u6027\u4e34\u5e8a\u3002<\/span><\/p>\n


<\/p>\n

\u5357\u4eac\u4f20\u5947\u662f\u62e5\u6709\u5168\u7403\u552f\u4e00\u4e00\u4e2aBCMA\u9776\u70b9\u7684\u53cc\u8868\u4f4dCAR\u7ed3\u6784\u77e5\u8bc6\u4ea7\u6743\uff0c\u62e5\u6709\u66f4\u9ad8\u7684\u7406\u8bba\u7ed3\u5408\u6548\u7387\uff0c\u4e14\u5728\u975e\u5b8c\u5168\u53ef\u6bd4\u53e3\u5f84\u4e0b\u5f55\u5f97\u66f4\u9ad8\u7684\u5b8c\u5168\u7f13\u89e3\u7387\u3001\u590d\u53d1\u7387\uff0c\u76ee\u524d\u4f20\u5947\u516c\u53f8\u6b63\u4e0e\u5f3a\u751f\u516c\u53f8\u5171\u540c\u63a8\u8350\u5168\u7403\u8303\u56f4\u5546\u4e1a\u5316\u3002<\/span><\/p>\n


<\/p>\n

\"\u56fd\u9645\u5de8\u5934\u91cd\u91d1\u52a0\u7801\u7ec6\u80de\u6cbb\u7597\uff0c\u5546\u4e1a\u5316\u8fdb\u7a0b\u6709\u671b\u8d85\u9884\u671f\"<\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
\n

\u6211\u56fd\u6709\u671b\u8dd1\u51fa\u5168\u7403\u6838\u5fc3\u8d44\u4ea7<\/strong><\/span><\/p>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n


<\/p>\n

\u5728\u7ec6\u80de\u6cbb\u7597\u9886\u57df\uff0c\u6211\u56fd\u4e0e\u6b27\u7f8e\u5dee\u8ddd\u5f88\u5c0f\u7684\uff0c\u5177\u6709\u4e00\u5b9a\u7684\u5386\u53f2\u5fc5\u7136\u6027\u3002\u5c0f\u5206\u5b50\u65b0\u836f\u7206\u53d1\u7684\u65f6\u4ee3\uff0c\u662f\u7f8e\u56fd\u76841900\u5e74-1970\u5e74\uff0c\u6211\u56fd\u5f7c\u65f6\u4ecd\u5904\u4e8e\u6218\u4e71\u548c\u5c01\u95ed\u72b6\u6001\uff0c\u79d1\u7814\u5b9e\u529b\u548c\u5236\u836f\u5b9e\u529b\u8584\u5f31\uff0c\u9519\u8fc7\u4e86\u53d1\u5c55\u673a\u9047\u3002<\/span><\/p>\n


<\/p>\n

\u6297\u4f53\u836f\u65f6\u4ee3\u662f1980\u5e74\u5f00\u59cb\uff0c\u4ee5\u5229\u59a5\u6614\u5355\u6297\u4e0a\u5e02\u4e3a\u6807\u5fd7\uff0c\u4f46\u662f1980\u5e74\u6211\u56fd\u6539\u9769\u5f00\u653e\u521a\u5f00\u59cb\uff0c\u5de5\u4e1a\u5b9e\u529b\u548c\u79d1\u7814\u5b9e\u529b\u4ecd\u5904\u4e8e\u57f9\u80b2\u4e2d\uff0c\u518d\u6b21\u9519\u8fc7\u53d1\u5c55\u826f\u673a\uff0c\u4f46\u662f\u6211\u56fd\u5728\u6297\u4f53\u836f\u9886\u57df\u7684\u5dee\u8ddd\u5df2\u5927\u5e45\u7f29\u5c0f\uff0c\u5982\u4eca\u5df2\u7ecf\u8fbe\u5230\u5feb\u901f\u8ddf\u8e2a\u5168\u7403\u65b0\u8fdb\u4e34\u5e8a\u9776\u70b9\u7684\u6c34\u5e73\u3002<\/span><\/p>\n


<\/p>\n

2005\u5e74\u5f00\u59cb\u7684\u7ec6\u80de\u6cbb\u7597\u65f6\u4ee3\uff0c\u6211\u4eec\u5728\u57fa\u7840\u79d1\u7814\u4e0a\u5df2\u7ecf\u9010\u6b65\u9760\u8fd1\u6b27\u7f8e\u6c34\u5e73\uff0c\u6211\u56fd\u60a3\u8005\u6570\u91cf\u5e9e\u5927\uff0c\u5927\u91cf\u6d77\u5916\u4f18\u79c0\u79d1\u5b66\u5bb6\u4e5f\u57282000\u5e74\u4e4b\u540e\u56de\u56fd\u4efb\u6559\u6216\u521b\u4e1a\uff0c\u9776\u70b9\u53d1\u73b0\u5177\u6709\u590d\u6742\u6027\u3001\u5076\u7136\u6027\u7684\u7279\u70b9\uff0c\u6211\u56fd\u7ec6\u80de\u6cbb\u7597\u5e03\u5c40\u9776\u70b9\u591a\uff0c\u7814\u53d1\u6295\u5165\u5927\uff0c\u53d1\u73b0\u91cd\u78c5\u9776\u70b9\u6982\u7387\u9ad8\u3002\u5929\u65f6\u5730\u5229\u4eba\u548c\uff0c\u6211\u56fd\u6709\u671b\u5728\u7ec6\u80de\u6cbb\u7597\u9886\u57df\u5f2f\u9053\u8d85\u8f66\uff0c\u8dd1\u51fa\u5168\u7403\u6838\u5fc3\u8d44\u4ea7\u3002<\/span><\/p>\n


<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n
<\/section>\n
\n

\u4e34\u5e8a\u8bd5\u9a8c\u53ca\u5546\u4e1a\u5316\u8fdb\u7a0b\u6709\u671b\u8d85\u9884\u671f<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n
\n


<\/p>\n

CAR-T\u7597\u6cd5\u4f5c\u4e3a\u7a81\u7834\u6027\u7597\u6cd5\uff0c\u53c8\u517c\u5177\u4e34\u5e8a\u6025\u9700\u7279\u70b9\uff0c\u5546\u4e1a\u5316\u8fdb\u7a0b\u6709\u671b\u52a0\u901f\uff0c\u7406\u8bba\u4e0a\u53ef\u7533\u62a5\u6709\u6761\u4ef6\u4e0a\u5e02\u3002<\/span><\/p>\n


<\/p>\n

\u4f20\u7edf\u836f\u7269\u5ba1\u6279\u9700\u8981\u7ecf\u8fc7\u4e09\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5176\u5185\u5728\u903b\u8f91\u5728\u4e8e:\u4e34\u5e8aI\u671f\u7528\u4e8e\u5b89\u5168\u6027\u8bc4\u4ef7\uff0c\u4e34\u5e8aII\u671f\u7528\u4e8e\u5242\u91cf\u9009\u62e9\u53c2\u8003\uff0c\u4e34\u5e8aIII\u671f\u7528\u4e8e\u5927\u89c4\u6a21\u9a8c\u8bc1\u6548\u679c\u3002\u6211\u4eec\u8ba4\u4e3a\uff0c\u7ec6\u80de\u6cbb\u7597\u4f5c\u4e3a\u4e00\u79cd\u65b0\u578b\u6cbb\u7597\u836f\u54c1\uff0c\u4e34\u5e8a\u8bd5\u9a8c\u6709\u4e00\u5b9a\u7279\u6b8a\u6027\u3002<\/span><\/p>\n


<\/p>\n

\u9996\u5148\uff0c\u5f53\u524d\u7ec6\u80de\u6cbb\u7597\u4e34\u5e8a\u4ea7\u54c1\u4e3b\u8981\u9002\u5e94\u75c7\u4e3a\u590d\u53d1\u96be\u6cbb\u7684\u8840\u6db2\u80bf\u7624\uff0c\u60a3\u8005\u75be\u75c5\u8fdb\u5c55\u5f88\u5feb\uff0c\u96be\u4ee5\u7b49\u5f85\u4ea7\u54c1\u4e0a\u5e02\uff0c\u5176\u6b21\u7ec6\u80de\u6cbb\u7597\u76ee\u524d\u4ecd\u662f\u9ad8\u5ea6\u4e2a\u6027\u5316\u4ea7\u54c1\uff0c\u5242\u91cf\u548c\u6700\u7ec8\u4ea7\u54c1\u6d3b\u6027\u8ddf\u60a3\u8005\u5177\u4f53\u75c5\u60c5\u8fdb\u5c55\uff0c\u8eab\u4f53\u72b6\u6001\u5dee\u5f02\uff0cT\u7ec6\u80de\u8d28\u91cf\uff0c\u5bf9\u514d\u75ab\u56e0\u5b50\u98ce\u66b4\u7684\u8010\u53d7\u7a0b\u5ea6\u90fd\u6709\u8f83\u5927\u5173\u7cfb\uff0c\u96be\u4ee5\u786e\u5b9a\u7edf\u4e00\u7684\u5242\u91cf\u548c\u6d3b\u6027\u6807\u51c6\u3002\u56e0\u6b64\uff0c\u4e34\u5e8aII\u671f\u53c2\u8003\u610f\u4e49\u76f8\u5bf9\u6709\u9650\u3002<\/span><\/p>\n


<\/p>\n

\u4e8b\u5b9e\u4e0a\uff0c\u6839\u636e2017\u5e7412\u6708\u9881\u5e03\u7684\u300a\u7ec6\u80de\u5236\u54c1\u7814\u7a76\u4e0e\u8bc4\u4ef7\u6280\u672f\u6307\u5bfc\u539f\u5219(\u8bd5\u884c)\u300b\uff0c\u660e\u786e\u6211\u56fd\u7ec6\u80de\u6cbb\u7597\u4e34\u5e8a\u8bd5\u9a8c\u91c7\u7528\u201c\u65e9\u671f\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u201d\u548c\u201c\u786e\u8bc1\u6027\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u201d\u4e24\u4e2a\u9636\u6bb5\u7684\u5f62\u5f0f\u3002<\/span><\/p>\n

\u65e9\u671f\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u7684\u7814\u7a76\u5185\u5bb9\u539f\u5219\u4e0a\u5e94\u5305\u62ec\u521d\u6b65\u7684\u5b89\u5168\u6027\u8bc4\u4ef7\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76\u3001\u521d\u6b65\u7684\u836f\u6548\u5b66\u7814\u7a76\u548c\u5242\u91cf\u63a2\u7d22\u7814\u7a76\u3002\u5e76\u6307\u51fa\u201c\u5fc5\u8981\u65f6\u9f13\u52b1\u4e0e\u836f\u54c1\u5ba1\u8bc4\u673a\u6784\u6c9f\u901a\u4ea4\u6d41\uff0c\u4ee5\u786e\u4fdd\u786e\u8bc1\u6027\u4e34\u5e8a\u8bd5\u9a8c\u65b9\u6848\u8bbe\u8ba1\u7684\u5408\u7406\u6027\uff0c\u6709\u5229\u4e8e\u7814\u7a76\u7ed3\u679c\u7684\u7814\u5224\u548c\u62df\u7533\u62a5\u4ea7\u54c1\u7684\u6ce8\u518c\u4e0a\u5e02\u201d\u3002<\/span><\/p>\n


<\/p>\n

\u300a\u539f\u5219\u300b\u89e3\u8bfb\u4e2d\u660e\u786e\u201c\u975e\u6ce8\u518c\u4e34\u5e8a\u5b9e\u9a8c\u6570\u636e\u7684\u53ef\u63a5\u53d7\u7a0b\u5ea6\u53d6\u51b3\u4e8e\u4e34\u5e8a\u8bd5\u9a8c\u7528\u6837\u54c1\u4e0e\u7533\u62a5\u6ce8\u518c\u4ea7\u54c1\u7684\u4e00\u81f4\u6027\u4ee5\u53ca\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u7684\u4ea7\u751f\u8fc7\u7a0b\uff0c\u6570\u636e\u7684\u771f\u5b9e\u6027\u3001\u5b8c\u6574\u6027\u3001\u51c6\u786e\u6027\u548c\u53ef\u6eaf\u6e90\u6027\uff0c\u4ee5\u53ca\u56fd\u5bb6\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u603b\u5c40\u5bf9\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6838\u67e5\u7ed3\u679c\u7b49\u60c5\u51b5\u7efc\u5408\u79d1\u5b66\u8bc4\u4ef7\u3002\u201d<\/span><\/p>\n


<\/p>\n

\u5728\u56fd\u5185\u4f01\u4e1a\u4e2d\uff0c\u91d1\u65af\u745e\u751f\u7269\u79d1\u6280(\u5357\u4eac\u4f20\u5947)\u3001\u5b89\u79d1\u751f\u7269(\u535a\u751f\u5409\u5b89\u79d1)\u3001\u4e0a\u6d77\u4f18\u5361\u8fea\u3001\u5317\u4eac\u827a\u5999\u795e\u5dde\u3001\u6df1\u5733\u56e0\u8bfa\u514d\u75ab\u7b49\u5747\u6709\u4e0d\u540c\u7a0b\u5ea6\u7684\u975e\u6ce8\u518c\u4e34\u5e8a\u6570\u636e\u3002\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\u8fdb\u7a0b\u53ca\u5546\u4e1a\u5316\u8fdb\u7a0b\u6709\u671b\u8d85\u51fa\u5e02\u573a\u9884\u671f\u3002\uff08<\/span>\u4e2d\u4fe1\u5efa\u6295\u8bc1\u5238\uff1a\u8d3a\u83ca\u9896<\/span>\uff09<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\u8bc6\u522b\u5fae\u4fe1\u4e8c\u7ef4\u7801\uff0c\u6dfb\u52a0\u751f\u7269\u5236\u54c1\u5708\u5c0f\u7f16\uff0c\u7b26\u5408\u6761\u4ef6\u8005\u5373\u53ef\u52a0\u5165\u751f\u7269\u5236\u54c1\u5708\u5fae\u4fe1\u7fa4\uff01<\/span><\/strong>
<\/p>\n

\u8bf7\u6ce8\u660e\uff1a\u59d3\u540d+\u7814\u7a76\u65b9\u5411\uff01<\/span><\/strong><\/span><\/p>\n

\n

\"\u56fd\u9645\u5de8\u5934\u91cd\u91d1\u52a0\u7801\u7ec6\u80de\u6cbb\u7597\uff0c\u5546\u4e1a\u5316\u8fdb\u7a0b\u6709\u671b\u8d85\u9884\u671f\"<\/p>\n<\/section>\n

\"\u56fd\u9645\u5de8\u5934\u91cd\u91d1\u52a0\u7801\u7ec6\u80de\u6cbb\u7597\uff0c\u5546\u4e1a\u5316\u8fdb\u7a0b\u6709\u671b\u8d85\u9884\u671f\"
<\/span><\/p>\n

\n
\n
\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
\n
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