{"id":74833,"date":"2019-01-27T00:00:50","date_gmt":"2019-02-01T05:37:47","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/74833\/"},"modified":"2019-02-01T13:37:49","modified_gmt":"2019-02-01T05:37:49","slug":"7640e21672","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/74833\/","title":{"rendered":"\u6297\u6d41\u611f\u5c0f\u5206\u5b50\u836f\u7269\u7814\u7a76\u8fdb\u5c55"},"content":{"rendered":"
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\u6297\u6d41\u611f\u5c0f\u5206\u5b50\u836f\u7269\u7814\u7a76\u8fdb\u5c55<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\"\u6297\u6d41\u611f\u5c0f\u5206\u5b50\u836f\u7269\u7814\u7a76\u8fdb\u5c55\"<\/p>\n

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\"\u6297\u6d41\u611f\u5c0f\u5206\u5b50\u836f\u7269\u7814\u7a76\u8fdb\u5c55\"<\/p>\n

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\"\u6297\u6d41\u611f\u5c0f\u5206\u5b50\u836f\u7269\u7814\u7a76\u8fdb\u5c55\"<\/p>\n

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\u6b63 \u6587<\/strong><\/p>\n<\/section>\n

\"\u6297\u6d41\u611f\u5c0f\u5206\u5b50\u836f\u7269\u7814\u7a76\u8fdb\u5c55\"<\/p>\n

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\u6d41\u611f\u75c5\u6bd2\uff08influenza virus\uff09\u5c5e\u4e8e\u6b63\u9ecf\u75c5\u6bd2\u79d1\uff08orthomyxoviridae\uff09\u6210\u5458\uff0c\u5206\u4e3a\u7532\u578b\u6d41\u611f\uff08influenza <\/span>virus A\uff0cIVA\uff09\u3001\u4e59\u578b\u6d41\u611f\uff08influenza virus B\uff0cIVB\uff09\u3001<\/span>\u4e19\u578b\u6d41\u611f\uff08influenza virus C\uff0cIVC\uff09 \u548c\u4e01\u578b\u6d41\u611f<\/span>\uff08influenza virus D\uff0cIVD\uff094 \u79cd\u7c7b\u578b\u3002<\/span><\/p>\n

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\u4eba\u7c7b\u547c\u5438\u9053\u4e0a\u76ae\u7ec6\u80de\u8868\u9762\u7684\u553e\u6db2\u9178\u4e3b\u8981\u4e3a\u03b1-2,6 \u7cd6\u82f7\u952e\uff0c\u800c\u79bd\u7c7b\u547c\u5438\u9053\u4e0a\u76ae\u7ec6\u80de\u4e3b\u8981\u4e3a\u03b1-2,3 \u7cd6\u82f7\u952e\uff0c\u4e00\u822c\u8ba4\u4e3a\u8fd9\u79cd\u553e\u6db2\u9178\u6784\u578b\u4e4b\u95f4\u7684\u5dee\u5f02\u662f\u51b3\u5b9a\u4eba\u7c7b\u6d41\u611f\u75c5\u6bd2\u548c\u79bd\u6d41\u611f\u75c5\u6bd2\u4e0d\u540c\u5bbf\u4e3b\u55dc\u6027\u7684\u4e3b\u8981\u56e0\u7d20[4]\u3002<\/p>\n

\u7136\u800c\u8fd9\u79cd\u5dee\u5f02\u5e76\u4e0d\u7edd\u5bf9\uff0c\u7814\u7a76\u53d1\u73b0\uff0c\u4eba\u7c7b\u547c\u5438\u9053\u4e0a\u76ae\u7ec6\u80de\u540c\u6837\u5b58\u5728\u5c11\u91cf\u7684\u03b1-2,3 \u553e\u6db2\u9178\uff0c\u8fd9\u662f\u90e8\u5206\u79bd\u6d41\u611f\u75c5\u6bd2\u80fd\u591f\u611f\u67d3\u4eba\u7684\u56e0\u7d20\u4e4b\u4e00\u3002\u75c5\u6bd2HA \u86cb\u767d\u7684\u5355\u70b9\u7a81\u53d8\u5373\u53ef\u6539\u53d8\u5bf9\u4e0d\u540c\u553e\u6db2\u9178\u6784\u578b\u7684\u7ed3\u5408\u80fd\u529b\uff0c\u8fdb\u800c\u6539\u53d8\u75c5\u6bd2\u55dc\u6027\u3002<\/p>\n

\u4e00\u65e6\u7ed3\u5408\u5230\u7ec6\u80de\u4e4b\u4e0a\uff0c\u6d41\u611f\u75c5\u6bd2\u901a\u8fc74 \u79cd\u673a\u5236\u5b8c\u6210\u5185\u541e\u8fc7\u7a0b\uff1a\u7f51\u683c\u86cb\u767d\u4f9d\u8d56\u7684\u5185\u541e\uff0c\u5c0f\u7a9d\u86cb\u767d\u4f9d\u8d56\u7684\u5185\u541e\uff0c\u975e\u7f51\u683c\u86cb\u767d\/ \u5c0f\u7a9d\u86cb\u767d\u4f9d\u8d56\u7684\u5185\u541e\u4ee5\u53ca\u80de\u541e\u3002\u4e00\u822c\u8ba4\u4e3a\u7f51\u683c\u86cb\u767d\u4f9d\u8d56\u7684\u5185\u541e\u9014\u5f84\u662f\u6d41\u611f\u75c5\u6bd2\u7684\u4e3b\u8981\u5185\u541e\u9014\u5f84[5-7]\u3002<\/span><\/p>\n

\u5185\u541e\u4e4b\u540e\uff0c\u75c5\u6bd2\u8868\u9762\u7684HA0 \u88ab\u5bbf\u4e3b\u86cb\u767d\u9176\u5207\u5272\u4e3aHA1 \u548cHA2\u3002\u5728\u9178\u6027\u7684\u5185\u541e\u4f53\u73af\u5883\u4e2d\uff0cHA\u53d8\u6784\u4e4b\u540e\u66b4\u9732\u51faHA2 N \u7aef\u7684\u878d\u5408\u80bd\u3002\u6700\u540e\u878d\u5408\u80bd\u63d2\u5165\u5230\u7ec6\u80de\u819c\u4e2d\uff0c\u89e6\u53d1\u819c\u878d\u5408\u8fc7\u7a0b\u3002<\/p>\n

\u4e0e\u6b64\u540c\u65f6\uff0c\u75c5\u6bd2\u8868\u9762\u7684M2 \u79bb\u5b50\u901a\u9053\u5c06\u5185\u541e\u4f53\u4e2d\u7684H+ \u6cf5\u5165\u75c5\u6bd2\u5185\u90e8\uff0c\u8bf1\u53d1\u75c5\u6bd2\u5185\u90e8\u7ed3\u6784\u7684\u89e3\u4f53\uff08\u4f8b\u5982NP \u548cM\u86cb\u767d\u7684\u89e3\u805a\uff09\uff0c\u66b4\u9732\u51fa\u6e38\u79bb\u7684\u6838\u7cd6\u6838\u86cb\u767d\u590d\u5408\u4f53\uff08vRNP\uff09\u3002\u5f53\u819c\u878d\u5408\u8fc7\u7a0b\u5b8c\u6210\u540e\uff0cvRNP \u8fdb\u5165\u7ec6\u80de\u8d28\uff0c\u5e76\u8f6c\u8fd0\u81f3\u7ec6\u80de\u6838\u4e2d\uff0c\u5b8c\u6210\u57fa\u56e0\u7ec4\u590d\u5236\u548c\u8f6c\u5f55\u3002PA\u3001PB1 \u548cPB2 \u7ec4\u6210\u6d41\u611f\u75c5\u6bd2RNA \u4f9d\u8d56\u7684RNA \u805a\u5408<\/span>\u9176\uff08RNA-dependent RNA polymerase\uff0cRdRp\uff09[8]\u3002<\/span><\/p>\n

RdRp \u4ee5vRNA \u4e3a\u6a21\u677f\u8f6c\u5f55\u51famRNA \u548ccRNA\uff0c\u8fdb\u4e00\u6b65\u4ee5cRNA \u4e3a\u5927\u91cf\u590d\u5236vRNA\u3002\u75c5\u6bd2\u7684\u51fa\u82bd\u4f9d\u8d56NA \u7684\u795e\u7ecf\u6c28\u9178\u9176\u529f\u80fd\uff0cNA \u8d1f\u8d23\u5207\u65adHA \u548c\u553e\u6db2\u9178\u4e4b\u95f4\u7684\u8fde\u63a5\uff0c\u4f7f\u75c5\u6bd2\u9897\u7c92\u91ca\u653e\u3002NA \u7684\u53e6\u4e00\u9879\u529f\u80fd\u662f\u8d1f\u8d23\u5207\u6389\u75c5\u6bd2\u8868\u9762\u7684\u7cd6\u86cb\u767d\uff0c\u9632\u6b62\u75c5\u6bd2\u9897\u7c92\u7684\u805a\u96c6\u3002<\/p>\n

\u6d41\u611f\u75c5\u6bd2\u611f\u67d3\u590d\u5236\u7684\u6bcf\u4e00\u6b65\u90fd\u6709\u75c5\u6bd2\u81ea\u8eab\u7f16\u7801\u7684\u86cb\u767d\u548c\u548c\u5bbf\u4e3b\u7ec6\u80de\u86cb\u767d\u53c2\u4e0e\u3002\u76ee\u524d\uff0c\u9488\u5bf9\u6d41\u611f\u75c5\u6bd2\u611f\u67d3\u590d\u5236\u5468\u671f\u7684\u5404\u4e2a\u9636\u6bb5\u90fd\u6709\u836f\u7269\u7814\u53d1\u62a5\u9053\uff08\u56fe1\uff09\u3002<\/p>\n

\"\u6297\u6d41\u611f\u5c0f\u5206\u5b50\u836f\u7269\u7814\u7a76\u8fdb\u5c55\"<\/p>\n

\u56fe1 \u9488\u5bf9\u6d41\u611f\u611f\u67d3\u590d\u5236\u5168\u5468\u671f\u7684\u6297\u6d41\u611f\u836f\u7269\u6f5c\u5728\u9776\u70b9\u548c\u7814\u7a76\u7684\u836f\u7269<\/span><\/strong><\/p>\n

\u76ee\u524d\uff0c\u5168\u7403\u7ecf\u8fc7\u5404\u56fd\u836f\u54c1\u7ba1\u7406\u90e8\u95e8\u6279\u51c6\u4e0a\u5e02\u7684\u6297\u6d41\u611f\u836f\u7269\u67094 \u5927\u7c7b7 \u4e2a\u54c1\u79cd\uff0c\u5206\u522b\u4e3a\uff1a<\/p>\n

M2 \u79bb\u5b50\u901a\u9053\u6291\u5236\u5242\u91d1\u521a\u70f7\u80fa\uff081966 \u5e74\uff0c\u7f8e\u56fd\u9996\u5148\u4e0a\u5e02\uff09\u548c\u91d1\u521a\u4e59\u80fa\uff081993 \u5e74\uff0c\u7f8e\u56fd\u9996\u5148\u4e0a\u5e02\uff09\uff0c\u795e\u7ecf\u6c28\u9178\u9176\u6291\u5236\u5242\u624e\u90a3\u7c73\u97e6\uff081999 \u5e74\uff0c\u6fb3\u5927\u5229\u4e9a\u548c\u7f8e\u56fd\u9996\u5148\u4e0a\u5e02\uff09\u78f7\u9178\u5965\u53f8\u4ed6\u97e6\uff081999 \u5e74\uff0c\u745e\u58eb\u9996\u5148\u4e0a\u5e02\uff0c\u9646\u7eed\u5728\u52a0\u62ff\u5927\u3001\u6b27\u6d32\u3001\u7f8e\u56fd\u548c\u4e2d\u56fd\u4e0a\u5e02\uff09\u548c\u5e15\u62c9\u7c73\u97e6\uff082010\u5e74\uff0c\u97e9\u56fd\u9996\u5148\u4e0a\u5e02\uff09\uff0cRNA \u805a\u5408\u9176\u6291\u5236\u5242\u6cd5\u5339\u62c9\u97e6\uff082014 \u5e74\uff0c\u65e5\u672c\u9996\u5148\u6279\u51c6\uff09\uff0c\u8840\u51dd\u7d20HA \u6291\u5236\u5242\u963f\u6bd4\u591a\u5c14\uff081993 \u5e74\uff0c\u4fc4\u7f57\u65af\u4e0a\u5e02\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

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\n
\n

2<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n

\u9776\u5411\u75c5\u6bd2\u5438\u9644\u5185\u541e\u9636\u6bb5<\/strong>\u7684\u6297\u6d41\u611f\u6291\u5236\u5242<\/strong><\/p>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n

\u75c5\u6bd2\u8868\u9762\u7684HA \u662f\u75c5\u6bd2\u5438\u9644\u7684\u4e3b\u8981\u529f\u80fd\u86cb\u767d\uff0c\u9776\u5411HA \u7684\u6297\u5438\u9644\u6291\u5236\u5242\u7814\u53d1\u6210\u4e3a\u6b64\u7c7b\u6291\u5236\u5242\u7814\u7a76<\/span>\u7684\u70ed\u70b9\uff0c\u6297\u4f53\u7c7b\u836f\u7269\u7684\u4f5c\u7528\u673a\u5236\u591a\u4e3a\u963b\u65ad\u75c5\u6bd2\u7684\u5438<\/span>\u9644\u8fc7\u7a0b\u3002<\/span><\/p>\n

\u786b\u9178\u53f3\u65cb\u7cd6\u9150\u662f\u8f83\u65e9\u53d1\u73b0\u7684\u6297\u5438\u9644\u6291\u5236\u5242\uff0c<\/span>\u5176\u8868\u9762\u7684\u8d1f\u7535\u8377\u80fd\u591f\u6291\u5236\u75c5\u6bd2\u9897\u7c92\u548c\u7ec6\u80de\u8868\u9762\u7684\u5438<\/span>\u9644\uff0c\u5bf9HA \u548cNA \u4ecb\u5bfc\u7684\u5438\u9644\u5747\u6709\u6291\u5236\u6d3b\u6027\u3002<\/span><\/p>\n

\u75c5\u6bd2\u7684\u5438\u9644\u6d89\u53ca\u5bbf\u4e3b\u8868\u9762\u7684\u553e\u6db2\u9178\uff0c\u9776\u5411\u5bbf<\/span>\u553e\u6db2\u9178\u7684\u6297\u75c5\u6bd2\u836f\u7269\u7814\u7a76\u4e5f\u53d6\u5f97\u4e86\u91cd\u8981\u8fdb\u5c55\u3002<\/span><\/p>\n

DAS181\uff08fludase\uff09 \u662f\u8be5\u7c7b\u836f\u7269\u7684\u5178\u578b\u4ee3\u8868[9]\u3002<\/span><\/p>\n

DAS181 \u662f\u7531\u4e24\u4e2a\u529f\u80fd\u57df\u6784\u6210\u7684\u5927\u5206\u5b50\u836f\u7269\uff0c\u4e00\u662f<\/span>\u809d\u7d20\u7ed3\u5408\u57df\uff0c\u4e8c\u662f\u553e\u6db2\u9178\u9176\u57df\u3002\u8be5\u836f\u7269\u80fd\u591f\u5207\u9664\u547c<\/span>\u5438\u9053\u8868\u9762\u7684\u553e\u6db2\u9178\u5206\u5b50\uff0c\u8fdb\u800c\u963b\u6b62\u6d41\u611f\u75c5\u6bd2\u7684\u5438<\/span>\u9644\u3002\u8be5\u836f\u7269\u5bf9H3N2, H7N9, H5N1, H1N1 \u7b49\u6d41\u611f<\/span>\u4e9a\u578b\u5728\u4f53\u5185\u548c\u4f53\u5916\u5747\u5177\u6709\u826f\u597d\u7684\u6297\u75c5\u6bd2\u6d3b\u6027\uff0c\u76ee\u524d<\/span>\u8be5\u836f\u5df2\u7ecf\u5b8c\u6210\u6297\u6d41\u611f\u7684\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5e76\u83b7\u5f97\u7f8e\u56fd<\/span>FDA \u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u3002<\/span><\/p>\n

\u5438\u9644\u540e\u7684\u5185\u541e\u8fc7\u7a0b\u9700\u8981\u591a\u79cd\u5bbf\u4e3b\u86cb\u767d\u7684\u53c2\u4e0e\uff0c\u8be5\u7c7b\u6291\u5236\u5242\u7684\u4e3b\u8981\u4f5c\u7528\u9776\u6807\u4e3a\u5bbf\u4e3b\u86cb\u767d\u3002\u6c34\u98de\u84df\u7d20<\/span>\uff08silymarin\uff09\u80fd\u591f\u4f5c\u7528\u4e8e\u7f51\u683c\u86cb\u767d\u4ecb\u5bfc\u7684\u5185\u541e\u9014\u5f84\uff0c<\/span>\u8fdb\u800c\u6291\u5236\u6d41\u611f\u75c5\u6bd2\u5438\u9644\u540e\u7684\u5185\u541e[10]\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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3<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
\n

\u9776\u5411\u75c5\u6bd2\u819c\u878d\u5408\u9636\u6bb5\u7684\u6297\u6d41\u611f\u6291\u5236\u5242<\/strong><\/p>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n
\n
\n
\n

\u6d41\u611f\u75c5\u6bd2\u819c\u878d\u5408\u4e3b\u8981\u7531HA \u7684\u53d8\u6784\u4ecb\u5bfc\uff0c\u56e0\u6b64HA \u7684\u53d8\u6784\u6291\u5236\u5242\u6210\u4e3a\u6297\u819c\u878d\u5408\u6291\u5236\u5242\u7684\u7814\u7a76\u70ed\u70b9<\/span>\u4e4b\u4e00\u3002<\/span><\/p>\n

BMY-27709 \u80fd\u591f\u6709\u6548\u6291\u5236H1 \u548cH2 \u4e9a\u578b\u7684<\/span>\u6d41\u611f\u75c5\u6bd2\uff0c\u5176\u9488\u5bf9A \u578b\u6d41\u611f\u75c5\u6bd2\u7684\u4f53\u5916IC50 \u4ecb\u4e8e<\/span>3~8 \u03bcM \u4e4b\u95f4[11]\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u6709\u7814\u7a76\u53d1\u73b0stachyflin<\/span>\u4e5f\u53ef\u4ee5\u6291\u5236HA \u7684\u53d8\u6784\uff0c\u4ece\u800c\u6291\u5236\u6d41\u611f\u75c5\u6bd2\u7684\u590d<\/span>\u5236[12]\u3002<\/span><\/p>\n

\u963f\u6bd4\u591a\u5c14\u662f\u524d\u82cf\u8054\u7814\u53d1\u7684\u6297\u6d41\u611f\u836f\u7269\uff0c\u5176\u5177\u6709\u5e7f\u8c31\u6297\u75c5\u6bd2\u6d3b\u6027\u3002\u7814\u7a76\u8868\u660e\uff0c\u963f\u6bd4\u591a\u5c14\u4f5c\u7528\u4e8e<\/span>HA \u7684\u819c\u878d\u5408\uff0c\u4ee5\u53d8\u6784\u6291\u5236\u5242\u7684\u5f62\u5f0f\u53d1\u6325\u6297\u6d41\u611f\u6d3b<\/span>\u6027[13]\u3002<\/span><\/p>\n

\u6d41\u611f\u75c5\u6bd2\u7684\u819c\u878d\u5408\u4f9d\u8d56\u4e8e\u5185\u541e\u4f53\u9178\u5316\u548c\u5bbf\u4e3b\u86cb\u767d\u9176\u7b49\u4e00\u7cfb\u5217\u5bbf\u4e3b\u9176\u7c7b\u3002<\/span><\/p>\n

\u8418\u83ab\u53f8\u4ed6\u3001\u4eae\u80bd\u7d20\u3001\u5361\u83ab<\/span>\u53f8\u4ed6\u3001\u6291\u80bd\u9176\u7b49\u4e00\u7cfb\u5217\u86cb\u767d\u9176\u88ab\u62a5\u9053\u6709\u6297\u6d41\u611f\u75c5\u6bd2<\/span>\u6d3b\u6027\uff0c\u5176\u4f5c\u7528\u673a\u5236\u88ab\u8ba4\u4e3a\u662f\u6291\u5236\u5bbf\u4e3b\u86cb\u767d\u9176\u5bf9HA0<\/span>\u7684\u5207\u5272[14-17]\u3002<\/p>\n

V-ATPase \u6291\u5236\u5242\u5982\u5df4\u5f17\u6d1b\u9709\u7d20A1 \u7b49\u80fd\u591f\u963b\u65ad\u6c22\u79bb\u5b50\u8fdb\u5165\u5185\u541e\u4f53\uff0c\u6291\u5236\u5185\u541e\u4f53\u7684\u9178\u5316\uff0c<\/span>\u8fdb\u800c\u6291\u5236\u9178\u6027\u6761\u4ef6\u4e0bHA \u6240\u53d1\u751f\u7684\u53d8\u6784\uff0c\u4ece\u800c\u53d1\u6325<\/span>\u6297\u75c5\u6bd2\u6d3b\u6027[18]\u3002\u6c2f\u55b9\uff08chloroquine\uff09\u80fd\u591f\u901a\u8fc7\u8c03\u8282<\/span>\u5bbf\u4e3b\u7ec6\u80depH \u4ece\u800c\u6291\u5236\u6d41\u611f\u75c5\u6bd2\u7684\u5185\u541e\u8fc7\u7a0b\u3002\u7136\u800c\uff0c<\/span>\u4e00\u9879\u6c2f\u55b9\u9884\u9632\u6d41\u611f\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\u663e<\/span>\u793a\uff0c\u5065\u5eb7\u4eba\u7fa4\u670d\u7528\u6c2f\u55b9\u65e0\u6cd5\u9884\u9632\u6d41\u611f\u7684\u53d1\u751f[19]\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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4<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u9776\u5411\u75c5\u6bd2\u6838\u9178\u91ca\u653e\u7684\u6297\u6d41\u611f\u6291\u5236\u5242<\/strong><\/p>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n
\n
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\u8be5\u7c7b\u6291\u5236\u5242\u7684\u4f5c\u7528\u9776\u6807\u4e3b\u8981\u4e3aM2 \u79bb\u5b50\u901a\u9053\u6291\u5236\u5242\u3002M2 \u79bb\u5b50\u901a\u9053\u662f\u6700\u65e9\u6210\u529f\u7684\u6297\u6d41\u611f\u836f\u7269\u9776\u6807\uff0c<\/span>1960 \u5e74\u4ee3\u6279\u51c6\u7684\u91d1\u521a\u70f7\u80fa\u662f\u7ecf\u5178\u7684\u6297\u6d41\u611f\u836f\u7269[20]\u3002<\/span><\/p>\n

\u7ecf\u8fc7\u591a\u5e74\u7684\u4e34\u5e8a\u5e94\u7528\uff0c\u76ee\u524d\u91d1\u521a\u70f7\u80fa\u3001\u91d1\u521a\u4e59\u80fa\u7c7b\u5316\u5408\u7269\u5df2\u7ecf\u51fa\u73b0\u5e7f\u6cdb\u7684\u8010\u836f\u6027\uff0cWHO \u5df2\u4e0d\u63a8\u8350\u5176<\/span>\u4f5c\u4e3a\u5b63\u8282\u6027\u6d41\u611f\u7684\u6cbb\u7597\u836f\u7269\u3002\u975e\u70f7\u80fa\u7c7bM2 \u6291\u5236\u5242<\/span>\u6210\u4e3a\u76ee\u524d\u7814\u7a76\u7684\u5173\u6ce8\u70b9\u4e4b\u4e00\uff0c\u8be5\u7c7b\u836f\u7269\u4e3b\u8981\u5305\u62ec\u805a<\/span>\u80fa\u7c7b\u5316\u5408\u7269\uff08\u5982\u7cbe\u80fa\u3001\u7cbe\u8112\uff09\uff0c\u87ba\u54cc\u5576\u53ca\u5176\u884d\u751f\u7269\uff0c<\/span>\u4ee5\u53capinanamine \u7b49\u5929\u7136\u4ea7\u7269[21-23]\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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5<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u9776\u5411\u75c5\u6bd2\u6838\u9178\u590d\u5236\u9636\u6bb5\u7684\u6297\u6d41\u611f\u6291\u5236\u5242<\/strong><\/p>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n
\n
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\u8be5\u7c7b\u6291\u5236\u5242\u4e3b\u8981\u5206\u4e3a4 \u7c7b\uff1a PB2 \u5e3d\u5b50\u7ed3\u5408\u533a\u57df\u6291\u5236\u5242\uff0c\u6838\u82f7\u7c7b\u4f3c\u7269\uff0cPA \u6838\u9178\u5185\u5207\u9176\u6291\u5236\u5242\uff0c<\/span>\u5e72\u6270RdRp \u590d\u5408\u4f53\u7ec4\u88c5\u7684\u6291\u5236\u5242\u3002<\/span>PB2 \u5e3d\u5b50\u7ed3\u5408\u533a\u6291\u5236\u5242\u662f\u8fd1\u5e74\u6765\u6297\u6d41\u611f\u6291\u5236\u5242<\/span>\u7814\u7a76\u7684\u70ed\u70b9\uff0c\u5176\u5178\u578b\u4ee3\u8868\u662fVX787\u3002<\/span><\/p>\n

\u8be5\u7c7b\u5316\u5408\u7269<\/span>\u5bf9\u7532\u578b\u6d41\u611f\u7684\u4e3b\u8981\u4e9a\u578b\u4ee5\u53ca\u5965\u53f8\u4ed6\u97e6\u8010\u836f\u682a\u5747\u6709\u826f<\/span>\u597d\u7684\u4f53\u5916\u53ca\u4f53\u5185\u6297\u75c5\u6bd2\u6d3b\u6027\uff0c\u5176IC50 \u4f4e\u81f3\u7eb3\u6469\u5c14\u7ea7\u3002\u4f53\u5185\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u611f\u67d3\u540e96h \u7ed9\u836f\u4f9d\u7136\u80fd\u8fbe<\/span>\u5230100% \u7684\u4fdd\u62a4\u6548\u679c\u3002<\/span><\/p>\n

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\u4ee5\u6cd5\u5339\u62c9\u97e6\uff08favipiravir, T-705\uff09\u4e3a\u4ee3\u8868\u7684\u6838<\/span>\u82f7\u7c7b\u4f3c\u7269\u7531\u4e8e\u5177\u6709\u5e7f\u8c31\u6297\u75c5\u6bd2\u6d3b\u6027\uff0c\u4e00\u76f4\u4ee5\u6765\u662f<\/span>\u6297\u6d41\u611f\u836f\u7269\u7814\u53d1\u7684\u91cd\u70b9\u3002<\/span><\/p>\n

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\u8be5\u836f\u7269\u5bf9\u4e1d\u72b6\u75c5\u6bd2\u79d1\u3001\u5e03\u5c3c\u4e9a<\/span>\u75c5\u6bd2\u79d1\u3001\u6c99\u7c92\u75c5\u6bd2\u79d1\u3001\u62ab\u819c\u75c5\u6bd2\u79d1\u7b49\u70c8\u6027RNA \u75c5<\/span>\u6bd2\u79d1\u6210\u5458\u4ee5\u53ca\u6b63\u9ecf\u75c5\u6bd2\u79d1\u3001\u526f\u9ecf\u75c5\u6bd2\u79d1\u3001\u5c0fRNA<\/span>\u75c5\u6bd2\u79d1\u3001\u9ec4\u75c5\u6bd2\u79d1\u7b49\u975e\u70c8\u6027RNA \u75c5\u6bd2\u79d1\u6210\u5458\u5728\u4f53\u5916\u53ca\u4f53\u5185\u5747\u5177\u6709\u826f\u597d\u7684\u6291\u5236\u6548\u679c\u3002<\/span><\/p>\n

\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c<\/span>\u663e\u793a\uff0c\u6cd5\u5339\u62c9\u97e6\u80fd\u591f\u6709\u6548\u7f29\u77ed\u6d41\u611f\u75c5\u7a0b\u65f6\u95f4\uff0c\u964d<\/span>\u4f4e\u75c5\u6bd2\u8f7d\u91cf\u3002<\/span><\/p>\n

\u9664\u6b64\u4e4b\u5916\uff0cPA \u6838\u9178\u5185\u5207\u9176\u6291\u5236\u5242\u4ee5\u53ca\u5e72\u6270RdRp\u590d\u5408\u4f53\u7ec4\u88c5\u7684\u6291\u5236\u5242\u4e5f\u6709\u6587\u732e\u62a5\u9053\uff0cL-735822\u3001<\/span>flutimide \u4e3a\u6838\u9178\u5185\u5207\u9176\u6291\u5236\u5242\u7684\u4ee3\u8868\u6027\u6291\u5236\u5242[25]\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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6<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u9776\u5411\u75c5\u6bd2\u86cb\u767d\u7ffb\u8bd1\u548c\u7ec4\u88c5\u7684\u6297\u6d41\u611f\u6291\u5236\u5242<\/strong><\/p>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n
\n
\n
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\u785d\u5511\u5c3c\u7279\u662f\u76ee\u524d\u6297\u6d41\u611f\u836f\u7269\u7814\u7a76\u7684\u70ed\u70b9\u836f\u7269\u3002\u8be5\u836f\u662f\u7b2c\u4e00\u4e2a\u567b\u5511\u7c7b\u6297\u611f\u67d3\u836f\u7269\uff0c\u53ef\u6291\u5236\u5305\u62ec\u795e\u7ecf<\/span>\u6c28\u9178\u9176\u6291\u5236\u5242\u8010\u836f\u7684\u75c5\u6bd2\u682a\u5728\u5185\u7684\u591a\u79cd\u7c7b\u578b\u6d41\u611f<\/span>\u75c5\u6bd2\u7684\u590d\u5236\uff0c\u963b\u65ad\u7ffb\u8bd1\u540e\u9636\u6bb5\u75c5\u6bd2\u8840\u51dd\u7d20\u7684\u6210\u719f\u3002<\/span><\/p>\n

\u7ec6\u80de\u57f9\u517b\u7814\u7a76\u53d1\u73b0\uff0c\u785d\u5511\u5c3c\u7279\u53ef\u4e0e\u795e\u7ecf\u6c28\u9178\u9176\u6291\u5236\u5242\u53d1\u751f\u534f\u540c\u6548\u5e94\uff1b\u8fd8\u53ef\u6291\u5236\u547c\u5438\u9053\u75c5\u6bd2\u7684\u590d\u5236\uff0c\u5982<\/span>\u526f\u6d41\u611f\u75c5\u6bd2\u3001\u51a0\u72b6\u75c5\u6bd2\u4ee5\u53ca\u547c\u5438\u9053\u5408\u80de\u75c5\u6bd2\u3002\u76ee\u524d<\/span>\u5df2\u7ecf\u5b8c\u6210\u8be5\u836f\u7684\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u785d<\/span>\u5511\u5c3c\u7279\u53ef\u51cf\u5c11\u6025\u6027\u65e0\u5408\u5e76\u75c7\u6d41\u611f\u60a3\u8005\u7684\u75c7\u72b6\u6301\u7eed<\/span>\u65f6\u95f4[26]\u3002<\/p>\n

\u6838\u6291\u7d20\u80fd\u591f\u5f15\u8d77NP \u86cb\u767d\u7684\u805a\u96c6\uff0c\u963b\u788d\u8be5\u86cb\u767d\u5411\u7ec6\u80de\u6838\u5185\u7684\u8f6c\u8fd0\uff0c\u5bf9H1N1, H3N2 \u4ee5\u53caH5N1<\/span>\u5747\u6709\u826f\u597d\u6297\u75c5\u6bd2\u6d3b\u6027[27]\uff1b\u653e\u7ebf\u83cc\u916e\u548c\u8418\u666e\u751f\u80fd\u591f<\/span>\u963b\u6b62NP \u86cb\u767d\u7684\u591a\u805a\u5316[28-29]\uff1bIngavirin \u80fd\u591f\u76f4\u63a5\u5e72<\/span>\u6270NP \u86cb\u767d\u7684\u6838\u8f6c\u8fd0\uff0c\u8fdb\u800c\u53d1\u6325\u6297\u6d41\u611f\u6d3b\u6027[30]\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

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7<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u9776\u5411\u75c5\u6bd2\u91ca\u653e\u7684\u6297\u6d41\u611f\u6291\u5236\u5242<\/strong><\/p>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n
\n
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\u75c5\u6bd2\u51fa\u82bd\u540e\uff0c\u9700\u501f\u52a9\u81ea\u8eab\u7f16\u7801\u7684NA \u5207\u65ad\u75c5\u6bd2\u86cb\u767d\u548c\u5bbf\u4e3b\u7ec6\u80de\u8868\u9762\u553e\u6db2\u9178\u4e4b\u95f4\u7684\u8fde\u63a5\u3002\u76ee\u524d\uff0c\u8be5<\/span>\u7c7b\u6297\u6d41\u611f\u836f\u7269\u4e0a\u5e02\u54c1\u79cd\u6700\u591a\uff0c\u5305\u62ec\u5965\u53f8\u4ed6\u97e6\u3001\u5e15\u62c9<\/span>\u7c73\u97e6\u3001\u624e\u90a3\u7c73\u97e6\u3001\u62c9\u5c3c\u7c73\u97e6\u7b49[31]\u3002<\/span><\/p>\n

\u4e0eM2 \u79bb\u5b50\u901a\u9053\u6291\u5236\u5242\u7684\u673a\u5236\u4e0d\u540c\uff0cNA \u6291\u5236\u5242\u5bf9M2 \u79bb\u5b50\u901a\u9053\u6291\u5236\u5242\u8010\u836f\u682a\u5747\u6709\u6548\uff0c\u56e0\u6b64\u662f\u7ee7<\/span>\u70f7\u80fa\u7c7b\u836f\u7269\u4e4b\u540e\u7684\u4e3b\u6d41\u6297\u6d41\u611f\u836f\u7269\u3002\u624e\u90a3\u7c73\u97e6\u662f\u7f8e<\/span>\u56fdFDA \u6279\u51c6\u7684\u9996\u4e2aNA \u6291\u5236\u5242\uff0c\u5242\u578b\u4e3a\u5438\u5165\u5242\uff1b<\/span><\/p>\n

\u5965\u53f8\u4ed6\u97e61999 \u5e74\u88abFDA \u6279\u51c6\u4e0a\u5e02\uff0c\u53e3\u670d\u7ed9\u836f\uff0c\u662f\u76ee\u524d\u5e02\u573a\u4e0a\u7684\u4e00\u7ebf\u6297\u6d41\u611f\u836f\u7269\uff1b\u5e15\u62c9\u7c73\u97e6\u76ee\u524d\u5728\u4e2d<\/span>\u56fd\u3001\u65e5\u672c\u5df2\u7ecf\u83b7\u6279\uff0c\u7ed9\u836f\u65b9\u5f0f\u4e3a\u9759\u8109\u6ce8\u5c04\uff0c\u4e3b\u8981\u7528<\/span>\u4e8e\u91cd\u75c7\u6d41\u611f\u7684\u6551\u6cbb\uff1b\u62c9\u5c3c\u7c73\u97e6\u5728\u65e5\u672c\u83b7\u6279\uff0c\u5242\u578b\u4e3a<\/span>\u5438\u5165\u5242\uff0c\u6709\u7814\u7a76\u663e\u793a\u5176\u5bf9\u5965\u53f8\u4ed6\u97e6\u8010\u836f\u682a\u6709\u6548\u3002<\/span><\/p>\n

\u76ee<\/span>\u524dNA \u6291\u5236\u5242\u7c7b\u836f\u7269\u7684\u4e3b\u8981\u7814\u7a76\u91cd\u70b9\u662f\u5728\u5965\u53f8\u4ed6\u97e6<\/span>\u548c\u624e\u90a3\u7c73\u97e6\u7684\u57fa\u7840\u4e0a\u8fdb\u884c\u8fdb\u4e00\u6b65\u6539\u9020\uff0c\u4ee5\u514b\u670d\u6108\u6f14<\/span>\u6108\u70c8\u7684\u8010\u836f\u95ee\u9898\u3002<\/span><\/p>\n

NA \u662f\u6d41\u611f\u75c5\u6bd2\u7279\u6709\u7684\u9176\uff0c\u5bbf\u4e3b\u7ec6\u80de\u4e2d\u6ca1\u6709\u7c7b<\/span>\u4f3c\u7684\u9176\u7c7b\uff0c\u8f83\u4f4e\u7684\u6bd2\u6027\u98ce\u9669\u4f7f\u5f97\u8be5\u9176\u4e00\u76f4\u662f\u6297\u6d41\u611f<\/span>\u836f\u7269\u7814\u53d1\u7684\u70ed\u70b9\u9776\u6807\u3002<\/span><\/p>\n

\u76ee\u524d\u5bf9NA \u6291\u5236\u5242\u7684\u7814\u7a76\u65b9<\/span>\u5411\u4e3b\u8981\u6709\u65b0\u6bcd\u6838\u6291\u5236\u5242\u7b5b\u9009\u53ca\u884d\u751f\uff0c\u5171\u4ef7\u6291\u5236\u5242\u7814<\/span>\u7a76\uff0c\u4ee5\u53ca\u591a\u4ef7\u6291\u5236\u5242\u7814\u7a76\u3002<\/span><\/p>\n

\u4f46\u76ee\u524d\u4e3a\u6b62\uff0c\u672a\u6709\u63a8\u8fdb<\/span>\u5230\u4e34\u5e8a\u9636\u6bb5\u7684\u65b0\u6291\u5236\u5242\u62a5\u9053\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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8<\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n
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\u7ed3\u8bed<\/strong><\/p>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n
\n
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\n

\u6d41\u611f\u75c5\u6bd2\u53d8\u5f02\u5feb\u3001\u5371\u5bb3\u5927\uff0c\u662f\u4e00\u76f4\u4ee5\u6765\u6700\u53d7\u5173\u6ce8\u7684\u75c5\u6bd2\u3002<\/span><\/p>\n

\u6297\u6d41\u611f\u836f\u7269\u7684\u7814\u53d1\u56e0\u6b64\u6210\u4e3a\u6297\u75c5\u6bd2\u836f\u7269<\/span>\u7814\u53d1\u9886\u57df\u7684\u70ed\u70b9\u3002\u867d\u7136\u76ee\u524d\u6297\u6d41\u611f\u836f\u7269\u4e0a\u5e02\u54c1\u79cd\u6700<\/span>\u591a\uff0c\u4f46\u968f\u7740\u5404\u4e2a\u4e00\u7ebf\u836f\u7269\u8010\u836f\u5f62\u52bf\u7684\u6076\u5316\uff0c\u5bf9\u65b0\u578b<\/span>\u6297\u6d41\u611f\u836f\u7269\u7684\u9700\u6c42\u4e5f\u66f4\u52a0\u8feb\u5207\u3002<\/span><\/p>\n

\u503c\u5f97\u6b23\u6170\u7684\u662f\uff0c\u968f<\/span>\u7740\u6cd5\u5339\u62c9\u97e6\u3001\u785d\u5511\u5c3c\u7279\u3001VX787 \u7b49\u54c1\u79cd\u7684\u9646\u7eed\u4e0a\u5e02\uff0c<\/span>\u4e00\u7ebf\u836f\u7269\u7684\u8010\u836f\u5a01\u80c1\u6709\u671b\u5728\u8fd1\u5e74\u5185\u5f97\u5230\u7f13\u89e3\u3002<\/span><\/p>\n

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\u53c2\u8003\u6587\u732e<\/strong><\/p>\n<\/section>\n

\"\u6297\u6d41\u611f\u5c0f\u5206\u5b50\u836f\u7269\u7814\u7a76\u8fdb\u5c55\"<\/p>\n

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\u8be6\u89c1\u539f\u6587\uff0c\u4e34\u5e8a\u836f\u7269\u6cbb\u7597\u6742\u5fd7 \u7b2c16\u5377 \u7b2c1 \u671f 2018 \u5e741 \u6708<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6587\u7ae0\u5185\u5bb9\u4e3a\u4f5c\u8005\u89c2\u70b9\uff0c\u4e0d\u4ee3\u8868\u672c\u516c\u4f17\u53f7\u7acb\u573a\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u6297\u6d41\u611f\u5c0f\u5206\u5b50\u836f\u7269\u7814\u7a76\u8fdb\u5c55 \u6765\u6e90 \u4e34\u5e8a\u836f\u7269\u6cbb\u7597\u6742\u5fd7 \u7b2c16\u5377 \u7b2c1 \u671f 2018 \u5e741 \u6708 […]<\/p>\n","protected":false},"author":1,"featured_media":74834,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/74833"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=74833"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/74833\/revisions"}],"predecessor-version":[{"id":74846,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/74833\/revisions\/74846"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/74834"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=74833"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=74833"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=74833"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}