{"id":74850,"date":"2019-01-27T00:00:50","date_gmt":"2019-02-01T05:37:55","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/74850\/"},"modified":"2019-02-01T13:37:57","modified_gmt":"2019-02-01T05:37:57","slug":"f37053ebf0","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/74850\/","title":{"rendered":"CDE\u6587\u7ae0|\u6297\u6291\u90c1\u836f\u7684\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u6280\u672f\u6307\u5bfc\u539f\u5219\u8981\u70b9\u53ca\u8ba8\u8bba"},"content":{"rendered":"
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Key points and discussion of the technical guidance for drug clinical trials of antidepressants<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2. 2 \u53d7\u8bd5\u4eba\u7fa4<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5efa\u8bae\u9009\u62e9\u4e2d\u5ea6\u53ca\u4e2d\u5ea6\u4ee5\u4e0a\u4e25\u91cd\u7a0b\u5ea6\u7684\u6291\u90c1\u75c7\u60a3<\/span>\u8005\u4f5c\u4e3a\u53d7\u8bd5\u8005\uff0c\u5e76\u7ed9\u51fa\u4e86\u76f8\u5e94\u91cf\u8868\u8bc4\u5206\u7684\u63a8\u8350\u754c\u503c\u3002<\/span><\/p>\n

\u901a\u5e38\uff0c\u786e\u8bc1\u6027\u4e34\u5e8a\u8bd5\u9a8c\u7684\u76ee\u7684\u662f\u4e3a\u836f\u54c1\u6ce8\u518c\u4e0a\u5e02\u670d<\/span>\u52a1\uff0c\u786e\u8bc1\u6027\u8bd5\u9a8c\u7684\u8bbe\u8ba1\u5e94\u6700\u5927\u7a0b\u5ea6\u5730\u6a21\u62df\u4e34\u5e8a\u6cbb\u7597<\/span>\u5b9e\u8df5\u3002<\/span><\/p>\n

\u56e0\u6b64\uff0c\u8bd5\u9a8c\u4e2d\u7684\u53d7\u8bd5\u8005\u5e94\u5c3d\u53ef\u80fd\u4e0e\u836f\u54c1\u7684\u76ee<\/span>\u6807\u9002\u5e94\u8bc1\u4eba\u7fa4\u4e00\u81f4\uff0c\u53d7\u8bd5\u8005\u7b5b\u9009\u6807\u51c6\u5e94\u4e0e\u76ee\u6807\u9002\u5e94<\/span>\u8bc1\u4eba\u7fa4\u7279\u5f81\u76f8\u5bf9\u5e94\u3002<\/span><\/p>\n

\u5bf9\u4e8e\u6291\u90c1\u75c7\u6765\u8bf4\uff0c\u53bb\u533b\u9662\u5c31\u8bca<\/span>\u5e76\u88ab\u5efa\u8bae\u63a5\u53d7\u89c4\u5f8b\u670d\u836f\u6cbb\u7597\u7684\u60a3\u8005\u7684\u75be\u75c5\u4e25\u91cd\u7a0b\u5ea6<\/span>\u901a\u5e38\u5df2\u8fbe\u5230\u4e2d\u5ea6\u53ca\u4e2d\u5ea6\u4ee5\u4e0a\u3002\u56e0\u6b64\uff0c\u6297\u6291\u90c1\u836f\u7684\u786e<\/span>\u8bc1\u6027\u4e34\u5e8a\u8bd5\u9a8c\u63a8\u8350\u9009\u62e9\u6b64\u7c7b\u578b\u60a3\u8005\u4f5c\u4e3a\u53d7\u8bd5\u8005\u3002<\/span><\/p>\n

\u53e6<\/span>\u4e00\u4e2a\u539f\u56e0\u662f\uff0c\u4ece\u75be\u75c5\u7279\u5f81\u7684\u89d2\u5ea6\u8003\u8651\uff0c\u8f7b\u5ea6\u6291\u90c1\u75c7\u60a3<\/span>\u8005\u7684\u75c7\u72b6\u6ce2\u52a8\u6027\u5927\uff0c\u5bb9\u6613\u53d7\u5230\u975e\u836f\u7269\u6cbb\u7597\u56e0\u7d20\u7684\u5f71<\/span>\u54cd\u3002<\/span><\/p>\n

\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u8f7b\u5ea6\u4e25\u91cd\u7a0b\u5ea6\u7684\u53d7\u8bd5\u8005\u7684\u5b89\u6170<\/span>\u5242\u6548\u5e94\u66f4\u4e3a\u660e\u663e\u4e14\u96be\u4ee5\u9884\u6d4b\uff0c\u4ece\u800c\u5f71\u54cd\u5230\u5bf9\u8bd5\u9a8c\u836f<\/span>\u7269\u5b89\u5168\u6709\u6548\u6027\u7684\u8bc4\u4ef7\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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 2.3 \u5bf9\u7167\u836f<\/span><\/strong>
<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u5728\u786e\u8bc1\u6027\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u5bf9\u7167\u836f\u7684\u9009\u62e9\u975e\u5e38\u5173\u952e\u3002\u63a8\u8350\u5728\u6297\u6291\u90c1\u836f\u7684\u786e\u8bc1\u6027\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u91c7<\/span>\u7528\u4e0e\u9633\u6027\u836f\u5bf9\u7167\u7684\u8bbe\u8ba1\u3002<\/span><\/p>\n

\u53ef\u4ee5\u662f\u4e0e\u9633\u6027\u836f\u5bf9\u7167\u7684\u4f18<\/span>\u6548\u6027\u8bd5\u9a8c\uff0c\u4e5f\u53ef\u4ee5\u9009\u62e9\u975e\u52a3\u6548\u8bbe\u8ba1\u3002\u5982\u679c\u9009\u62e9\u4e0e\u9633<\/span>\u6027\u836f\u5bf9\u7167\u7684\u975e\u52a3\u6548\u8bbe\u8ba1\uff0c\u9700\u8981\u52a0\u5165\u5b89\u6170\u5242\u7ec4\uff0c\u4e5f\u5c31\u662f<\/span>\u5e38\u8bf4\u7684\u4e09\u81c2\u8bd5\u9a8c\u3002<\/p>\n

\u9700\u8981\u6ce8\u610f\u7684\u662f\uff0c\u4e09\u81c2\u8bd5\u9a8c\u7684\u76ee\u7684\u4e0d\u5728\u4e8e\u8bd5\u9a8c\u836f\u4e0e\u5b89\u6170\u5242\u6bd4\u8f83\uff0c\u800c\u662f\u8003\u5bdf\u8bd5\u9a8c\u836f\u4e0e\u9633<\/span>\u6027\u5bf9\u7167\u836f\u5728\u4e34\u5e8a\u5b89\u5168\u6709\u6548\u6027\u65b9\u9762\u7684\u5dee\u5f02\u662f\u5426\u53ef\u4ee5\u88ab<\/span>\u63a5\u53d7\uff0c\u5b89\u6170\u5242\u662f\u4f5c\u4e3a\u8bd5\u9a8c\u5185\u90e8\u8d28\u91cf\u63a7\u5236\u7684\u6807\u51c6( \u68c0<\/span>\u6d4b\u7075\u654f\u5ea6) \u3002<\/span><\/p>\n

\u56e0\u6b64\uff0c\u4e3a\u4e86\u6700\u5927\u9650\u5ea6\u5730\u5c06\u8bd5\u9a8c\u836f\u7684\u6cbb\u7597\u7279\u70b9\u5c55\u73b0\u51fa\u6765\uff0c\u4e5f\u4e3a\u4e86\u80fd\u5c3d\u53ef\u80fd\u5168\u9762\u5730\u4e86\u89e3\u8bd5\u9a8c<\/span>\u836f\u7684\u4f18\u52a3\u52bf\uff0c\u5efa\u8bae\u9009\u62e9\u5df2\u4e0a\u5e02\u7684\u3001\u5177\u6709\u5b8c\u6574\u5145\u5206\u53ef\u9760<\/span>\u7684\u4e0a\u5e02\u524d\u4e34\u5e8a\u5b89\u5168\u6709\u6548\u6027\u6570\u636e\u7684( \u6216\u5145\u5206\u53ef\u9760\u7684\u5faa<\/span>\u8bc1\u8bc1\u636e\u7684) \u3001\u836f\u7406\u673a\u5236\u7c7b\u4f3c\u7684\u836f\u7269\u4f5c\u4e3a\u9633\u6027\u5bf9\u7167\u836f\u3002<\/span><\/p>\n

\u5bf9\u4e8e\u5b89\u6170\u5242\u7684\u4f7f\u7528\uff0c\u5404\u56fd\u76d1\u7ba1\u673a\u6784\u7684\u5efa\u8bae\u4e0d\u5c3d\u76f8\u540c\u3002\u7efc\u5408\u5206\u6790\u73b0\u9636\u6bb5\u6211\u56fd\u6297\u6291\u90c1\u521b\u65b0\u836f\u7684\u7814\u53d1\u73b0\u72b6\u548c\u8bd5<\/span>\u9a8c\u6761\u4ef6\uff0c\u8ba4\u4e3a\u5b89\u6170\u5242\u5e73\u884c\u5bf9\u7167\u7684\u8bd5\u9a8c\u8bbe\u8ba1\u66f4\u9002\u5408\u4e8e<\/span>\u5242\u91cf\u63a2\u7d22\u8bd5\u9a8c\uff0c\u5e76\u4e0d\u63a8\u8350\u7528\u4e8e\u5927\u6837\u672c\u7684\u786e\u8bc1\u6027\u4e34\u5e8a<\/span>\u8bd5\u9a8c\u3002<\/span><\/p>\n

\u4e3b\u8981\u539f\u56e0\u662f\uff0c\u76ee\u524d\u6297\u6291\u90c1\u836f\u7684\u6cbb\u7597\u673a\u5236\/\u9776\u70b9<\/span>\u5e76\u672a\u6709\u5927\u7684\u7a81\u7834\uff0c\u5373\u4f7f\u662f\u6297\u6291\u90c1\u521b\u65b0\u836f\uff0c\u591a\u6570\u4ecd\u4ee5\u5df2<\/span>\u77e5\u7684\u5355\u80fa\u80fd\u53d7\u4f53\u4e3a\u5bf9\u8c61\u8c03\u8282\u795e\u7ecf\u9012\u8d28\u6c34\u5e73\u3002<\/span><\/p>\n

\u5728\u6211<\/span>\u56fd\uff0c\u5df2\u6709\u591a\u4e2a\u8fd9\u79cd\u4f5c\u7528\u673a\u5236\u7684\u836f\u7269\u4e0a\u5e02\uff0c\u7ecf\u8fc7\u591a\u5e74\u4e34<\/span>\u5e8a\u9a8c\u8bc1\uff0c\u7597\u6548\u786e\u5b9e\u3001\u5b89\u5168\u6027\u53ef\u63a7\u3002\u56e0\u6b64\uff0c\u5bf9\u4e8e\u65b0\u5f00\u53d1<\/span>\u7684\u836f\u7269\uff0c\u4ec5\u8bc1\u660e\u76f8\u6bd4\u4e8e\u5b89\u6170\u5242\u7684\u7597\u6548\u5dee\u5f02\u662f\u4e0d\u591f\u7684\uff0c<\/span>\u5e94\u5728\u786e\u8bc1\u6027\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8bc1\u660e\u5728\u5b89\u5168\u6709\u6548\u6027\u65b9\u9762\u4f18\u4e8e<\/span>\u6216\u975e\u52a3\u4e8e\u5df2\u4e0a\u5e02\u7684\u836f\u7269\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2.4 \u8bc4\u4f30\u6307\u6807<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8bc4\u4f30\u6307\u6807\u7684\u9009\u62e9\u662f\u51b3\u5b9a\u8bd5\u9a8c\u6210\u8d25\u7684\u5173\u952e\u3002\u5bf9\u4e8e\u6297\u6291\u90c1\u836f\u7684\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u6765\u8bf4\uff0c\u8bc4\u4f30<\/span>\u5de5\u5177\u548c\u6307\u6807\u5df2\u8f83\u660e\u786e\u3002<\/span><\/p>\n

\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u7684\u8bc4\u4f30\u63a8\u8350\u4f7f<\/span>\u7528\u76ee\u524d\u901a\u884c\u7684\u3001\u7ecf\u8fc7\u9a8c\u8bc1\u7684\u3001\u5177\u6709\u826f\u597d\u4fe1\u6548\u5ea6\u7684\u91cf<\/span>\u8868: \u6c49\u5bc6\u5c14\u987f\u6291\u90c1\u91cf\u8868( Hamilton rating scale for depression\uff0c<\/span>HAMD) \u6216\u8499\u54e5\u9a6c\u5229\u2014\u827e\u65af\u4f2f\u683c\u6291\u90c1\u91cf\u8868 <\/span>( Montgomery-\ue6a6sberg depression rating scale\uff0cMADRS) \u3002<\/span><\/p>\n

\u9700\u8981\u6ce8\u610f\u4e8c\u8005\u5728\u8bc4\u4f30\u7ef4\u5ea6\u65b9\u9762\u7684\u5dee\u5f02\uff0c\u5728\u9009\u62e9\u65f6\uff0c\u5e94<\/span>\u4e88\u4ee5\u8003\u8651\uff0c\u5728\u65b9\u6848\u4e2d\u5e94\u4e88\u4ee5\u8bf4\u660e\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u57fa\u4e8e\u4e3b<\/span>\u8981\u7597\u6548\u6307\u6807( \u91cf\u8868\u8bc4\u5206) \u8ba1\u7b97\u6240\u5f97\u7684\u6709\u6548\u7387\u3001\u7f13\u89e3\u7387<\/span>\u548c\u590d\u53d1\u7387\uff0c\u662f\u4f53\u73b0\u4eba\u7fa4\u83b7\u76ca\u7684\u6307\u6807\uff0c\u5728\u836f\u54c1\u4e0a\u5e02\u540e\u7684<\/span>\u4e34\u5e8a\u8bca\u7597\u5b9e\u8df5\u4e2d\u5177\u6709\u91cd\u8981\u7684\u6307\u5bfc\u4e0e\u53c2\u7167\u610f\u4e49\uff0c\u56e0\u6b64\uff0c<\/span>\u5e94\u4f5c\u4e3a\u5173\u952e\u6b21\u8981\u7597\u6548\u6307\u6807\u8fdb\u884c\u7edf\u8ba1\u4e0e\u5206\u6790\u3002<\/span><\/p>\n

\u968f\u7740\u5bf9<\/span>\u75be\u75c5\u8ba4\u8bc6\u7684\u8fdb\u5c55\u548c\u4e34\u5e8a\u8bd5\u9a8c\u7406\u5ff5\u7684\u6269\u5145\uff0c\u4e00\u4e9b\u65b0\u578b<\/span>\u8bc4\u4f30\u5de5\u5177\u53ca\u76f8\u5e94\u7684\u8bc4\u4f30\u6307\u6807\u4f1a\u8fdb\u5165\u5230\u6297\u6291\u90c1\u836f\u7684\u4e34<\/span>\u5e8a\u7814\u7a76\u4e2d\u3002<\/span><\/p>\n

\u5728\u6ca1\u6709\u786e\u5b9a\u7406\u8bba\u4f9d\u636e\u548c\u5145\u5206\u5b9e\u8df5\u7ecf\u9a8c\u7684<\/span>\u524d\u63d0\u4e0b\uff0c\u4e0d\u5efa\u8bae\u91c7\u7528\u65b0\u578b\u7684\u8bc4\u4f30\u5de5\u5177\u53ca\u76f8\u5e94\u7684\u8bc4\u4f30<\/span>\u6307\u6807\u4f5c\u4e3a\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\uff0c\u4f46\u662f\uff0c\u9f13\u52b1\u5c06\u5176\u7eb3\u5165\u6b21\u8981\u7ec8<\/span>\u70b9\u8fdb\u884c\u8bc4\u4f30\u4e0e\u5206\u6790\u3002<\/span><\/p>\n

\u5728\u6297\u6291\u90c1\u836f\u7684\u786e\u8bc1\u6027\u4e34\u5e8a\u8bd5\u9a8c<\/span>\u4e2d\uff0c\u5efa\u8bae\u5bf9\u5df2\u77e5\u7684\u6216\u53ef\u9884\u671f\u7684\u4e0e\u836f\u7406\u673a\u5236\u76f8\u5173\u7684\u5b89\u5168\u6027\u98ce\u9669\u8fdb\u884c\u5168\u9762\u76d1\u6d4b\uff0c\u540c\u65f6\uff0c\u7ed3\u5408\u8bd5\u9a8c\u76ee\u7684\u3001\u8bd5\u9a8c<\/span>\u8bbe\u8ba1\u3001\u53d7\u8bd5\u8005\u7279\u5f81\u7b49\u7efc\u5408\u8003\u8651\u5176\u4ed6\u6f5c\u5728\u7684\u5b89\u5168\u6027\u98ce<\/span>\u9669\u3002<\/span>\u5e94\u5236\u5b9a\u8bd5\u9a8c\u4e2d\u7684\u98ce\u9669\u7ba1\u7406\u8ba1\u5212\u5e76\u4e25\u683c\u6267\u884c\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2. 5 \u8bd5\u9a8c\u7c7b\u578b<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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2.8 \u6570\u636e\u548c\u5b89\u5168\u76d1\u5bdf<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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3<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u6297\u6291\u90c1\u836f\u7684\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u6280\u672f\u6307\u5bfc\u539f\u5219\u8981\u70b9\u53ca\u8ba8\u8bba Key points and discussion of the […]<\/p>\n","protected":false},"author":1,"featured_media":74851,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/74850"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=74850"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/74850\/revisions"}],"predecessor-version":[{"id":74862,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/74850\/revisions\/74862"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/74851"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=74850"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=74850"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=74850"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}