{"id":75497,"date":"2018-12-27T00:00:50","date_gmt":"2019-02-01T05:45:34","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/75497\/"},"modified":"2019-02-01T13:45:34","modified_gmt":"2019-02-01T05:45:34","slug":"e21b5973e4","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/75497\/","title":{"rendered":"\u8fdb\u5ea6 | \u8d1d\u8fbe\u836f\u4e1a\u76d0\u9178\u6069\u838e\u66ff\u5c3c\u836f\u54c1\u6ce8\u518c\u7533\u8bf7\u83b7\u5f97\u53d7\u7406"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"text-align: center;text-indent: 0em;\"><strong><span style=\"color: rgb(171, 25, 66);\"><strong style=\"color: rgb(171, 25, 66);text-align: center;white-space: normal;\"><strong style=\"letter-spacing: 0.544px;text-align: left;widows: 1;\"><span style=\"letter-spacing: 0.544px;background-color: rgb(255, 255, 255);\"><img class=\"__bg_gif\"    width=\"auto\"  style=\"letter-spacing: 0.544px;font-family: \u4eff\u5b8b;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: auto !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/3-1548999934.gif\" alt=\"\u8fdb\u5ea6 | \u8d1d\u8fbe\u836f\u4e1a\u76d0\u9178\u6069\u838e\u66ff\u5c3c\u836f\u54c1\u6ce8\u518c\u7533\u8bf7\u83b7\u5f97\u53d7\u7406\" title=\"\u8fdb\u5ea6 | \u8d1d\u8fbe\u836f\u4e1a\u76d0\u9178\u6069\u838e\u66ff\u5c3c\u836f\u54c1\u6ce8\u518c\u7533\u8bf7\u83b7\u5f97\u53d7\u7406\"  \/><\/span><\/strong><\/strong>\u8d1d\u8fbe\u836f\u4e1a\u80a1\u4efd\u6709\u9650\u516c\u53f8<span style=\"text-align: justify;\">\u5173\u4e8e\u76d0\u9178\u6069\u838e\u66ff\u5c3c\u836f\u54c1\u6ce8\u518c\u7533\u8bf7\u83b7\u5f97\u53d7\u7406\u7684\u516c\u544a<\/span><\/span><\/strong><\/p>\n<p><br style=\"\"  \/>\u672c\u516c\u53f8\u53ca\u8463\u4e8b\u4f1a\u5168\u4f53\u6210\u5458\u4fdd\u8bc1\u4fe1\u606f\u62ab\u9732\u7684\u5185\u5bb9\u771f\u5b9e\u3001\u51c6\u786e\u3001\u5b8c\u6574\uff0c\u6ca1\u6709\u865a\u5047\u8bb0\u8f7d\u3001\u8bef\u5bfc\u6027\u9648\u8ff0\u6216\u91cd\u5927\u9057\u6f0f\u3002<br style=\"\"  \/><br style=\"\"  \/>12\u670826\u65e5\uff0c\u8d1d\u8fbe\u836f\u4e1a\u80a1\u4efd\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0\u201c\u8d1d\u8fbe\u836f\u4e1a\u201d\u6216\u201c\u516c\u53f8\u201d\uff09\u6536\u5230\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u7b7e\u53d1\u7684\u300a\u53d7\u7406\u901a\u77e5\u4e66\u300b\uff08\u53d7\u7406\u53f7\uff1aCXHS1800044\u56fd\u3001CXHS1800045\u56fd\u3001CXHS1800046\u56fd\uff09\uff0c\u516c\u53f8\u7533\u62a5\u7684\u76d0\u9178\u6069\u838e\u66ff\u5c3c\uff08X-396\uff09\u7528\u4e8e\u6b64\u524d\u63a5\u53d7\u8fc7\u514b\u5511\u66ff\u5c3c\u6cbb\u7597\u540e\u8fdb\u5c55\u7684\u6216\u8005\u5bf9\u514b\u5511\u66ff\u5c3c\u4e0d\u8010\u53d7\u7684\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08ALK\uff09\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u836f\u54c1\u6ce8\u518c\u7533\u8bf7\u5df2\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u53d7\u7406\uff0c\u73b0\u5c06\u5177\u4f53\u60c5\u51b5\u516c\u544a\u5982\u4e0b\uff1a<br style=\"\"  \/><br style=\"\"  \/><strong>\u4e00\u3001\u7533\u8bf7\u6ce8\u518c\u836f\u54c1\u7684\u57fa\u672c\u60c5\u51b5<\/strong><br style=\"\"  \/><br style=\"\"  \/>\u4ea7\u54c1\u540d\u79f0\uff1a\u76d0\u9178\u6069\u838e\u66ff\u5c3c\u3001\u76d0\u9178\u6069\u838e\u66ff\u5c3c\u80f6\u56ca<br style=\"\"  \/><br style=\"\"  \/>\u7533\u8bf7\u4e8b\u9879\uff1a\u65b0\u836f\u7533\u8bf7\uff1b\u7279\u6b8a\u5ba1\u6279\u7a0b\u5e8f\uff1b\u9644\u52a0\u7533\u8bf7\u4e8b\u9879\u5176\u4ed6<br style=\"\"  \/><br style=\"\"  \/>\u7533\u62a5\u9636\u6bb5\uff1a\u7533\u62a5\u751f\u4ea7<br style=\"\"  \/><br style=\"\"  \/>\u7533\u8bf7\u4eba\uff1a\u8d1d\u8fbe\u836f\u4e1a\u80a1\u4efd\u6709\u9650\u516c\u53f8<br style=\"\"  \/><br style=\"\"  \/>\u7ed3\u8bba\uff1a\u6839\u636e\u300a\u4e2d\u534e\u4eba\u6c11\u5171\u548c\u56fd\u884c\u653f\u8bb8\u53ef\u6cd5\u300b\u7b2c\u4e09\u5341\u4e8c\u6761\u7684\u89c4\u5b9a\uff0c\u7ecf\u5ba1\u67e5\uff0c\u51b3\u5b9a\u4e88\u4ee5\u53d7\u7406\u3002<br style=\"\"  \/><br style=\"\"  \/>\u53d7\u7406\u53f7\uff1aCXHS1800044\u56fd\uff0cCXHS1800045\u56fd\uff0cCXHS1800046\u56fd<br style=\"\"  \/><br style=\"\"  \/><strong>\u4e8c\u3001\u7533\u8bf7\u6ce8\u518c\u836f\u54c1\u7684\u7814\u7a76\u60c5\u51b5<\/strong><br style=\"\"  \/><br style=\"\"  \/>\u76d0\u9178\u6069\u838e\u66ff\u5c3c\uff08X-396\uff09\u662f\u516c\u53f8\u548c\u516c\u53f8\u63a7\u80a1\u5b50\u516c\u53f8XcoveryHoldings,Inc.\u5171\u540c\u5f00\u53d1\u7684\u5168\u65b0\u7684\u3001\u62e5\u6709\u5b8c\u5168\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684\u5206\u5b50\u5b9e\u4f53\u5316\u5408\u7269\uff0c\u662f\u4e00\u79cd\u65b0\u578b\u5f3a\u6548\u3001\u9ad8\u9009\u62e9\u6027\u7684\u65b0\u4e00\u4ee3ALK\u6291\u5236\u5242\uff0c\u6839\u636e\u56fd\u5bb6\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u603b\u5c40\u53d1\u5e03\u7684\u5316\u5b66\u836f\u54c1\u6ce8\u518c\u5206\u7c7b\u6539\u9769\u5de5\u4f5c\u65b9\u6848\u7684\u516c\u544a\uff082016\u5e74\u7b2c51\u53f7\uff09\uff0c\u76d0\u9178\u6069\u838e\u66ff\u5c3c\u5c5e\u4e8e\u201c\u5883\u5185\u5916\u5747\u672a\u4e0a\u5e02\u7684\u521b\u65b0\u836f\u201d\uff0c\u5176\u6ce8\u518c\u5206\u7c7b\u4e3a\u5316\u5b66\u836f\u54c11\u7c7b\u3002<br style=\"\"  \/><br style=\"\"  \/>\u672c\u6b21\u63d0\u4ea4\u76d0\u9178\u6069\u838e\u66ff\u5c3c\u836f\u54c1\u6ce8\u518c\u7533\u8bf7\u5e76\u83b7\u53d7\u7406\uff0c\u6807\u5fd7\u7740\u516c\u53f8\u65b0\u53d1\u53d6\u5f97\u4e86\u65b0\u7684\u8fdb\u5c55\uff0c\u4f5c\u4e3a\u65b0\u4e00\u4ee3ALK\u6291\u5236\u5242\uff0c\u5176\u7814\u53d1\u8fdb\u5ea6\u5728\u56fd\u5185\u5904\u4e8e\u9886\u5148\u6c34\u5e73\u3002\u516c\u53f8\u5728\u56fd\u5185\u5916\u5c31\u76d0\u9178\u6069\u838e\u66ff\u5c3c\u5f00\u5c55\u4e86\u591a\u9879\u4e34\u5e8a\u7814\u7a76\uff0c\u5176\u4e2d\u76d0\u9178\u6069\u838e\u66ff\u5c3c\u4e00\u7ebf\u6cbb\u7597ALK\u9633\u6027NSCLC\u60a3\u8005\u7684\u5168\u7403\u591a\u4e2d\u5fc3III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u76ee\u524d\u5df2\u7ecf\u5b8c\u6210\u5165\u7ec4\uff0c\u4e34\u5e8a\u7814\u7a76\u987a\u5229\u63a8\u8fdb\u4e2d\u3002<br style=\"\"  \/><br style=\"\"  \/>ALK\u878d\u5408\u57fa\u56e0\u5728NSCLC\u60a3\u8005\u4e2d\u7684\u9633\u6027\u7387\u7ea6\u4e3a5%\u5de6\u53f3\uff0c\u591a\u89c1\u4e8e\u5e74\u8f7b\u3001\u4e0d\u5438\u70df\u6216\u8f7b\u5ea6\u5438\u70df\u7684\u80ba\u817a\u764c\u60a3\u8005\u3002\u622a\u81f3\u672c\u516c\u544a\u65e5\uff0c\u5df2\u67093\u6b3eALK\u6291\u5236\u5242\u5728\u4e2d\u56fd\u533a\u57df\u4e0a\u5e02\u9500\u552e\uff0c\u5747\u4e3a\u8fdb\u53e3\u539f\u7814\u836f\uff0c\u5206\u522b\u662fPfizer\u516c\u53f8\u7684Crizotinib\uff082013\u5e741\u6708\u4e2d\u56fd\u4e0a\u5e02\uff09\u3001Novartis\u516c\u53f8\u7684Ceritinib\uff082018\u5e745\u6708\u4e2d\u56fd\u4e0a\u5e02\uff09\u548cRoche\u516c\u53f8\u7684Alectinib\uff082018\u5e748\u6708\u4e2d\u56fd\u4e0a\u5e02\uff09\uff0c\u5176\u4e2d\uff0cCrizotinib\u548cAlectinib\u7528\u4e8eALK\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027NSCLC\u60a3\u8005\u7684\u6cbb\u7597\uff0cCeritinib\u7528\u4e8e\u6b64\u524d\u63a5\u53d7\u8fc7\u514b\u5511\u66ff\u5c3c\u6cbb\u7597\u540e\u8fdb\u5c55\u7684\u6216\u8005\u5bf9\u514b\u5511\u66ff\u5c3c\u4e0d\u8010\u53d7\u7684ALK\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027NSCLC\u60a3\u8005\u3002<br style=\"\"  \/><br style=\"\"  \/>\u4e09\u3001\u5bf9\u516c\u53f8\u7684\u5f71\u54cd\u53ca\u98ce\u9669\u63d0\u793a<br style=\"\"  \/><br style=\"\"  \/>\u6839\u636e\u56fd\u5bb6\u836f\u54c1\u6ce8\u518c\u76f8\u5173\u6cd5\u89c4\u89c4\u5b9a\uff0c\u76d0\u9178\u6069\u838e\u66ff\u5c3c\u83b7\u5f97\u6ce8\u518c\u7533\u8bf7\u53d7\u7406\u540e\uff0c\u5c06\u7531\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\u8fdb\u884c\u5ba1\u8bc4\u5ba1\u6279\uff0c\u901a\u8fc7\u540e\u9881\u53d1\u65b0\u836f\u8bc1\u4e66\u5e76\u53ef\u6295\u5165\u751f\u4ea7\u3001\u9500\u552e\uff0c\u56e0\u4e3a\u68c0\u9a8c\u68c0\u6d4b\u3001\u6280\u672f\u5ba1\u8bc4\u7b49\u4e0d\u8ba1\u5165\u6cd5\u5b9a\u5ba1\u6279\u65f6\u9650\uff0c\u5ba1\u8bc4\u5ba1\u6279\u7684\u529e\u7ed3\u65f6\u95f4\u65e0\u6cd5\u9884\u4f30\uff0c\u6240\u4ee5\u672c\u6b21\u83b7\u5f97\u836f\u54c1\u6ce8\u518c\u53d7\u7406\u901a\u77e5\u4e66\u5bf9\u516c\u53f8\u8fd1\u671f\u4e1a\u7ee9\u4e0d\u4f1a\u4ea7\u751f\u5f71\u54cd\u3002<br style=\"\"  \/>\u8003\u8651\u5230\u836f\u54c1\u6ce8\u518c\u7533\u8bf7\u7684\u5ba1\u8bc4\u65f6\u95f4\u548c\u7ed3\u679c\u3001\u836f\u54c1\u83b7\u6279\u6295\u4ea7\u540e\u7684\u5177\u4f53\u9500\u552e\u60c5\u51b5\u5747\u5177\u6709\u4e00\u5b9a\u7684\u4e0d\u786e\u5b9a\u6027\uff0c\u656c\u8bf7\u5e7f\u5927\u6295\u8d44\u8005\u6ce8\u610f\u9632\u8303\u6295\u8d44\u98ce\u9669\uff0c\u8c28\u614e\u51b3\u7b56\u3002<br style=\"\"  \/><br style=\"\"  \/>\u7279\u6b64\u516c\u544a\u3002<br style=\"\"  \/><br style=\"\"  \/>\u8d1d\u8fbe\u836f\u4e1a\u80a1\u4efd\u6709\u9650\u516c\u53f8\u8463\u4e8b\u4f1a<br style=\"\"  \/>2018\u5e7412\u670826\u65e5<\/p>\n<section style=\"box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin: 10px 0%;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 50%;border-style: solid;border-width: 1px;border-radius: 0px;border-color: rgb(62, 62, 62);box-shadow: rgb(0, 0, 0) 0px 0px 0px;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin: 15px 0%;transform: translate3d(10px, 0px, 0px);-webkit-transform: translate3d(10px, 0px, 0px);-moz-transform: translate3d(10px, 0px, 0px);-o-transform: translate3d(10px, 0px, 0px);box-sizing: border-box;\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;background-color: rgb(255, 255, 255);box-shadow: rgb(160, 160, 160) 0px 0px 3px;border-style: none;border-width: 1px;border-radius: 0px;border-color: rgb(225, 225, 225);box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin: 15px 0% 10px;box-sizing: border-box;\">\n<section style=\"text-align: justify;letter-spacing: 1px;font-size: 14px;box-sizing: border-box;\">\n<p style=\"text-align: center;white-space: normal;box-sizing: border-box;\"><span style=\"color: rgb(249, 110, 87);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\"><\/strong><\/span><\/p>\n<p style=\"text-align: center;white-space: normal;box-sizing: border-box;\"><span style=\"color: rgb(160, 160, 160);box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u653f\u7b56 | \u8d44\u8baf | \u5e72\u8d27 | \u5206\u4eab<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-right: 0%;margin-bottom: 15px;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"display: inline-block;width: 90%;vertical-align: top;box-shadow: rgb(0, 0, 0) 0px 0px 0px;background-color: rgb(160, 160, 160);box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin: 2px 0%;box-sizing: border-box;\">\n<section style=\"color: rgb(255, 255, 255);letter-spacing: 1px;font-size: 12px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u957f\u6309\u626b\u7801\u5173\u6ce8\u6211\u4eec<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 50%;padding-right: 10px;padding-left: 15px;box-sizing: border-box;\">\n<section class=\"V5\" style=\"box-sizing: border-box;\" >\n<section style=\"margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;box-shadow: rgb(0, 0, 0) 0px 0px 0px;width: 100%;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u8d1d\u8fbe\u836f\u4e1a\u80a1\u4efd\u6709\u9650\u516c\u53f8\u5173\u4e8e\u76d0\u9178\u6069\u838e\u66ff\u5c3c\u836f\u54c1\u6ce8\u518c\u7533\u8bf7\u83b7\u5f97\u53d7\u7406\u7684\u516c\u544a \u672c\u516c\u53f8\u53ca\u8463\u4e8b\u4f1a\u5168\u4f53\u6210\u5458\u4fdd\u8bc1\u4fe1\u606f\u62ab\u9732\u7684\u5185\u5bb9\u771f\u5b9e\u3001 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":75498,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/75497"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=75497"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/75497\/revisions"}],"predecessor-version":[{"id":75500,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/75497\/revisions\/75500"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/75498"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=75497"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=75497"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=75497"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}