{"id":7584,"date":"2018-06-14T01:00:00","date_gmt":"2018-07-27T09:25:41","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e5%85%a8%e7%90%83%e6%9c%aa%e6%9d%a5%e6%8a%97%e7%97%85%e6%af%92%e8%8d%af%e5%b8%82%e5%9c%ba%ef%bc%8c%e7%be%a4%e9%9b%84%e9%80%90%e9%b9%bf%ef%bc%8c%e8%b0%81%e6%9d%a5%e9%97%ae%e9%bc%8e%ef%bc%9f\/"},"modified":"2018-07-27T17:25:45","modified_gmt":"2018-07-27T09:25:45","slug":"%e5%85%a8%e7%90%83%e6%9c%aa%e6%9d%a5%e6%8a%97%e7%97%85%e6%af%92%e8%8d%af%e5%b8%82%e5%9c%ba%ef%bc%8c%e7%be%a4%e9%9b%84%e9%80%90%e9%b9%bf%ef%bc%8c%e8%b0%81%e6%9d%a5%e9%97%ae%e9%bc%8e%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/7584\/","title":{"rendered":"\u5168\u7403\u672a\u6765\u6297\u75c5\u6bd2\u836f\u5e02\u573a\uff0c\u7fa4\u96c4\u9010\u9e7f\uff0c\u8c01\u6765\u95ee\u9f0e\uff1f"},"content":{"rendered":"
\n

<\/span><\/h1>\n

\"\u5168\u7403\u672a\u6765\u6297\u75c5\u6bd2\u836f\u5e02\u573a\uff0c\u7fa4\u96c4\u9010\u9e7f\uff0c\u8c01\u6765\u95ee\u9f0e\uff1f\"<\/p>\n

<\/span>
<\/h1>\n

\u5409\u5229\u5fb7\u6297\u75c5\u6bd2\u836f\u7269\u7684\u9500\u552e\u989d\u8fd1\u5e74\u867d\u7136\u6709\u6240\u4e0b\u964d\uff0c\u4f46\u9884\u8ba1\u57282024\u5e74\u7684\u6297\u75c5\u6bd2\u836f\u7269\u5e02\u573a\u4ecd\u7136\u53ef\u4ee5\u4fdd\u6301\u9886\u5148\u5730\u4f4d\u3002\u6839\u636eEvaluate\u7684\u62a5\u544a\u6570\u636e\u5206\u6790\uff0c\u5409\u5229\u5fb7\u4e19\u578b\u809d\u708e\u75c5\u6bd2\uff08HCV\uff09\u4e1a\u52a1\u7684\u9500\u552e\u989d\u76f4\u7ebf\u4e0b\u6ed1\uff0c\u4f7f\u5f97\u5176\u5728\u6297\u75c5\u6bd2\u836f\u7269\u9886\u57df\u7684\u5e02\u573a\u4efd\u989d\u5c06\u4ece2017\u5e74\u768455.0%\u4e0b\u964d\u52302024\u5e74\u768438.7%\u3002\u8fd9\u4e00\u4e0b\u964d\u4e3b\u8981\u6709\u4ee5\u4e0b\u51e0\u65b9\u9762\u7684\u56e0\u7d20\uff1a\u7531\u4e8e\u76ee\u524d\u6cbb\u7597\u65b9\u6cd5\u6cbb\u6108\u7387\u5c48\u6307\u53ef\u6570\u7684HCV\u5e02\u573a\u51cf\u5c11\u3001\u5e02\u573a\u4e0a\u591a\u4e2a\u7ade\u4e89\u5bf9\u624b\u7684\u5b9a\u4ef7\u9650\u5236\uff0cGSK\u7814\u53d1&\u9500\u552e\u7684\u53d1\u529b\u3001Teva\u9996\u4effTruvada\u83b7FDA\u6279\u51c6\u4e0a\u5e02\uff0c\u51ed\u501f\u4ef7\u683c\u4f18\u52bf\u52bf\u5fc5\u8986\u76d6\u66f4\u591a\u7684\u4eba\u7fa4\u4ee5\u53ca2017\u5e745\u67085\u65e5\u827e\u4f2f\u7ef4\u4e19\u809d\u65b0\u836fMavyret\u83b7\u6279\u4e0a\u5e02\u5bf9HCV\u5e02\u573a\u4efd\u989d\u7684\u62a2\u5360\uff0c\u5e76\u4e14Mavyret\u7684\u6cbb\u7597\u53ea\u9700\u77ed\u77ed\u76848\u5468\u7684\u7597\u7a0b\u3002
<\/h1>\n


<\/span><\/p>\n

\u524d\u6709\u731b\u864e\u540e\u6709\u8ffd\u5175\uff0c\u56db\u9762\u695a\u6b4c\uff0c\u5409\u5229\u5fb7\u4ecd\u7136\u7a33\u5750\u9493\u9c7c\u53f0<\/span><\/strong><\/span><\/h1>\n

\u636eEvaluate\u9884\u6d4b\uff0cMavyret\u7684\u9500\u552e\u989d\u5c06\u8fbe\u523029\u4ebf\u7f8e\u5143\uff0c\u5e76\u5c06\u52a9\u529b\u827e\u4f2f\u7ef4\u6210\u4e3a\u5168\u7403\u5341\u5927\u6297\u75c5\u6bd2\u836f\u7269\u516c\u53f8\u4e2d\u6392\u540d\u7b2c\u4e09\u7684\u516c\u53f8\u3002\u7136\u800c\uff0c\u56e0\u4e3a\u5409\u5229\u5fb7\u6297\u75c5\u6bd2\u7c7b\u836f\u7269\u7684\u91cd\u5fc3\u8d8a\u6765\u8d8a\u504f\u5411\u4e8e\u5176\u65b0\u9896\u7684\u827e\u6ecb\u75c5\u6bd2\u7597\u6cd5\uff0c\u9884\u8ba1\u5176Biktarvy\u57282024\u5e74\u7684\u9500\u552e\u989d\u53ef\u4ee5\u8fbe\u523061\u4ebf\u7f8e\u5143\uff0c\u5409\u5229\u5fb7\u6beb\u65e0\u7591\u95ee\u4ecd\u5c06\u5360\u636e\u699c\u9996\u3002\u4e0d\u8fc7\uff0c\u5409\u5229\u5fb7\u5728\u827e\u6ecb\u75c5\u6bd2\u9886\u57df\u5e76\u4e0d\u662f\u5355\u67aa\u5339\u9a6c\uff0c\u9884\u8ba1\u845b\u5170\u7d20\u53f2\u514b\u5c06\u57282024\u5e74\u51ed\u501f\u5176\u6297\u827e\u6ecb\u75c5\u6bd2\u7684\u836f\u54c1\u5728\u6297\u75c5\u6bd2\u836f\u7269\u516c\u53f8\u4e2d\u53ef\u4ee5\u540d\u5217\u7b2c\u4e8c\uff0c\u540e\u52b2\u5f88\u8db3\uff0c\u6b63\u5728\u7814\u53d1\u76845\u5927\u6297\u75c5\u6bd2\u836f\u7269\u4e2d\u5c31\u67093\u4e2a\u5c5e\u4e8eGSK\uff0c\u5e76\u4e14\u5df2\u8fdb\u5165\u4e34\u5e8aIII\u671f\u7684\u7814\u7a76\u3002<\/span><\/h1>\n


<\/span><\/p>\n

\u5f3a\u8005\u6052\u5f3a\uff0c\u4f46\u5c40\u52bf\u4e5f\u4f1a\u77ac\u606f\u4e07\u53d8<\/span><\/strong><\/span>
<\/h1>\n

\u4f5c\u4e3a\u52a0\u62ff\u5927\u5236\u836f\u5546\uff08Tekmira\uff09\u548cOnCore \u751f\u7269\u5236\u836f\u5408\u5e76\u7684\u4ea7\u7269\uff0cArbutus Biopharma\u4ee5\u5176\u4e59\u578b\u809d\u708e\u4ea7\u54c1AB-423\u6253\u8fdb\u524d10\u540d\u3002\u65e5\u672c\u76d0\u91ce\u4e49\u5236\u836f\uff08Shionogi\uff09\u516c\u53f8\u7684\u6d41\u611f\u91cd\u78c5\u836f\u7269Xofluza\u57282017\u5e74\u4e0e2016\u5e74\u76f8\u6bd4\u6709\u6240\u4e0b\u964d\u7684\u9884\u62a5\u4f7f\u5f97\u76d0\u91ce\u4e49\u6389\u51fa\u524d10\u540d\u3002\u7531\u4e8e\u65e5\u76ca\u589e\u52a0\u7684\u4eff\u5236\u836f\u7684\u7ade\u4e89\uff0c\u7f57\u6c0f\u7684\u6297\u75c5\u6bd2\u836f\u7269\u8fbe\u83f2(Tamiflu)\u548c\u4e07\u8d5b\u7ef4(Valcyte)\u9500\u91cf\u6b63\u5728\u4e0b\u964d\uff0c\u5c3d\u7ba1\u964d\u4f4e\u4e86\u7f57\u6c0f\u6297\u75c5\u6bd2\u836f\u7269\u7684\u5e02\u573a\u9884\u671f\uff0c\u4f46\u4ecd\u7136\u8ba9\u7f57\u6c0f\u83b7\u5f97\u4e86\u7b2c10\u540d\u7684\u4f4d\u7f6e\u3002\u4e00\u56fe\u53ef\u4ee5\u79d2\u61c2\u5168\u7403Top 10\u7684\u6297\u75c5\u6bd2\u836f\u7269\u516c\u53f8\u7684\u5e02\u573a\u4efd\u989d\u53ca\u9500\u552e\u589e\u957f\u60c5\u51b5\uff0c\u7f16\u8005\u5c31\u4e0d\u5728\u6b64\u8d58\u8ff0\u3002<\/span><\/h1>\n


<\/span><\/p>\n

<\/span><\/p>\n

\"\u5168\u7403\u672a\u6765\u6297\u75c5\u6bd2\u836f\u5e02\u573a\uff0c\u7fa4\u96c4\u9010\u9e7f\uff0c\u8c01\u6765\u95ee\u9f0e\uff1f\"<\/p>\n


<\/span><\/p>\n

\u56fe1 \u5168\u7403\u9500\u552e\u3001\u5e02\u573a\u4efd\u989d\u53ca\u5176\u589e\u957f\u60c5\u51b5<\/span><\/p>\n

\uff08\u6570\u636e\u6765\u6e90<\/span>: Evaluate, May 2018\uff09<\/span>
<\/span><\/p>\n


<\/p>\n

\u88681 2017-2024\u5e74\u5ea6\u5168\u7403\u5341\u5927\u6297\u75c5\u6bd2\u836f\u7269\u516c\u53f8\u53ca\u5176\u9500\u552e\u989d<\/span><\/strong><\/span><\/p>\n

<\/span><\/strong><\/p>\n

\"\u5168\u7403\u672a\u6765\u6297\u75c5\u6bd2\u836f\u5e02\u573a\uff0c\u7fa4\u96c4\u9010\u9e7f\uff0c\u8c01\u6765\u95ee\u9f0e\uff1f\"<\/p>\n

<\/span><\/strong>\uff08\u70b9\u51fb\u56fe\u7247\u53ef\u653e\u5927\u9605\u8bfb\uff09<\/span><\/p>\n

HCV\u548cHIV\u4e24\u5206\u5929\u4e0b\uff0c\u6d41\u611f\u699c\u4e0a\u65e0\u540d<\/span><\/strong><\/span><\/p>\n

\u5168\u7403\u91cd\u78c5\u6297\u75c5\u6bd2\u836f\u7269\u4e3b\u8981\u96c6\u4e2d\u5206\u5e03\u4e8eHCV\u548cHIV\u4e24\u5927\u677f\u5757\u3002\u6d41\u611f\u75c5\u6bd2\u836f\u7269\u5728\u5168\u74035\u5927\u6392\u540d\u91cc\u76ee\u524d\u8fd8\u699c\u4e0a\u65e0\u540d\u3002\u662f\u6d41\u611f\u5e02\u573a\u4e0a\u836f\u7269\u50a8\u5907\u4e0d\u8db3\uff0c\u53ef\u53ca\u6027\u7f3a\u4f4d\u8fd8\u662f\u6297\u6d41\u611f\u75c5\u6bd2\u836f\u7269\u4ef7\u683c\u6ca1\u6709\u4f18\u52bf\uff1f<\/span><\/p>\n


<\/span><\/p>\n

\u4e19\u578b\u75c5\u6bd2\u6027\u809d\u708e\uff0c\u7b80\u79f0\u4e3a\u4e19\u578b\u809d\u708e\u3001\u4e19\u809d\uff0c\u662f\u4e00\u79cd\u7531\u4e19\u578b\u809d\u708e\u75c5\u6bd2\uff08<\/span>HCV<\/span>\uff09\u611f\u67d3\u5f15\u8d77\u7684\u75c5\u6bd2\u6027\u809d\u708e\uff0c\u4e3b\u8981\u7ecf\u8f93\u8840\u3001\u9488\u523a\u3001\u5438\u6bd2\u7b49\u4f20\u67d3\u4f20\u64ad\uff0c\u5168\u7403<\/span>HCV<\/span>\u7684\u611f\u67d3\u7387\u7ea6\u4e3a<\/span>3%<\/span>\uff0c\u4f30\u8ba1\u7ea6<\/span>1.8<\/span>\u4ebf\u4eba\u611f\u67d3\u4e86<\/span>HCV<\/span>\uff0c\u6bcf\u5e74\u65b0\u53d1\u4e19\u578b\u809d\u708e\u75c5\u4f8b\u7ea6<\/span>3.5<\/span>\u4e07\u4f8b\u3002\u4e19\u578b\u809d\u708e\u5448\u5168\u7403\u6027\u6d41\u884c\uff0c\u4f1a\u5f15\u53d1\u809d\u810f\u708e\u75c7\uff0c\u8ba9\u809d\u810f\u5931\u53bb\u6b63\u5e38\u529f\u80fd\uff0c\u53ef\u5bfc\u81f4\u809d\u810f\u6162\u6027\u708e\u75c7\u574f\u6b7b\u548c\u7ea4\u7ef4\u5316\u6216\u662f\u51fa\u73b0\u8870\u7aed\uff0c\u90e8\u5206\u60a3\u8005\u53ef\u53d1\u5c55\u4e3a\u809d\u786c\u5316\u751a\u81f3<\/span>\u809d\u764c\u7b49\u4e25\u91cd\u75c7\u72b6\uff0c\u5bfc\u81f4\u6b7b\u4ea1<\/span>\u3002\u672a\u6765<\/span>20<\/span>\u5e74\u5185\u4e0e<\/span>HCV<\/span>\u611f\u67d3\u76f8\u5173\u7684\u6b7b\u4ea1\u7387\u5c06\u7ee7\u7eed\u589e\u52a0\uff0c\u5bf9\u60a3\u8005\u7684\u5065\u5eb7\u548c\u751f\u547d\u5371\u5bb3\u6781\u5927\uff0c\u5df2\u6210\u4e3a\u4e25\u91cd\u7684\u793e\u4f1a\u548c\u516c\u5171\u536b\u751f\u95ee\u9898\u3002<\/span>\u636e\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u7edf\u8ba1\uff0c\u5168\u7403\u7ea6\u6709<\/span>7100\u4e07\u540d\u4e19\u809d\u60a3\u8005\uff0c\u6570\u636e\u89e6\u76ee\u60ca\u5fc3\u3002<\/span><\/span><\/p>\n


<\/span><\/span><\/p>\n

\u827e\u6ecb\u75c5\u662f\u7531\u4eba\u7c7b\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2\uff08HIV\uff09\u5f15\u8d77\u7684\uff0c\u827e\u6ecb\u75c5\u662f\u4e00\u79cd\u80fd\u653b\u51fb\u4eba\u4f53\u514d\u75ab\u7cfb\u7edf\u7684\u91cd\u5ea6\u4f20\u67d3\u75c5\u3002\u5b83\u7684\u6700\u5927\u7279\u70b9\u662f\u653b\u51fb\u4eba\u4f53\u514d\u75ab\u7cfb\u7edf\uff0c\u5e76\u5c06\u514d\u75ab\u7cfb\u7edf\u4e2d\u6700\u91cd\u8981\u7684CD4T\u6dcb\u5df4\u7ec6\u80de\u4f5c\u4e3a\u4e3b\u8981\u653b\u51fb\u76ee\u6807\uff0c\u5bfc\u81f4\u4eba\u4f53\u7684\u514d\u75ab\u7cfb\u7edf\u51e0\u4e4e\u5b8c\u5168\u762b\u75ea\uff0c\u8eab\u5904\u5404\u79cd\u75be\u75c5\u7684\u4fb5\u88ad\u4e0b\uff0c\u80bf\u7624\u7b49\u7684\u60a3\u75c5\u7387\u6301\u7eed\u4e0a\u5347\uff0c\u6700\u7ec8\u5bfc\u81f4\u6b7b\u4ea1\u3002\u76ee\u524d\u8fd8\u6ca1\u6709\u80fd\u591f\u5f7b\u5e95\u6cbb\u6108\u827e\u6ecb\u75c5\u7684\u836f\u7269\uff0c\u4f46\u662f\u73b0\u6709\u7684\u836f\u7269\u5df2\u7ecf\u628a\u827e\u6ecb\u75c5\u4ece\u4e00\u4e2a\u4ee4\u4eba\u6050\u60e7\u7684\u75c5\u53d8\u4e3a\u53ef\u4ee5\u63a7\u5236\u7684\u6162\u6027\u75c5\u3002\u5e38\u7528\u7684\u6297HIV\u836f\u7269\u7531\u86cb\u767d\u9176\u6291\u5236\u5242\u3001\u6574\u5408\u9176\u6291\u5236\u5242\u3001\u6838\u82f7\u7c7b\u53cd\u8f6c\u5f55\u9176\u6291\u5236\u5242\u3001\u975e\u6838\u82f7\u7c7b\u53cd\u8f6c\u5f55\u9176<\/span>\u6291\u5236\u5242\u3001\u878d\u5408\u8fdb\u5165\u6291\u5236\u5242\u6784\u6210\u3002\u7531\u4e8eHIV\u75c5\u6bd2\u6781\u6613\u7a81\u53d8\u4e14\u653b\u51fb\u4eba\u7c7b\u7684\u514d\u75ab\u7cfb\u7edf\uff0c\u6cbb\u7597\u827e\u6ecb\u75c5\u7684\u65b9\u6cd5\u4e00\u822c\u662f\u8054\u5408\u7528\u836f\uff0c\u5373\u628a\u51e0\u79cd\u673a\u7406\u4e0d\u540c\u7684\u836f\u7269\u6df7\u5408\u8d77\u6765\u8054\u5408\u7528\u836f\u3002\u827e\u6ecb\u75c5\u6bcf\u5e74\u9020\u6210\u6570\u767e\u4ee5\u4e07\u7684\u4eba\u5458\u6b7b\u4ea1\uff0c\u800c\u4e14\u6b7b\u4ea1\u7387\u57fa\u672c\u5c31\u662f100%\u3002\u622a\u81f3\u76ee\u524d\u4e3a\u6b62\uff0c\u534a\u4e2a\u4e16\u7eaa\u7684\u65f6\u95f4\uff0c\u5168\u4e16\u754c\u56e0\u827e\u6ecb\u75c5\u6b7b\u4ea1\u7684\u4eba\u6570\uff0c\u5c06\u8fd1\u4e00\u4ebf\u4eba\u3002HIV\u836f\u7269\u7684\u5e02\u573a\u4e0d\u7528\u7f16\u8005\u5927\u8086\u6e32\u67d3\u3002\u5e0c\u671b\u66f4\u591a\u66f4\u6709\u6548\u7684\u836f\u7269\u95ee\u4e16\u7ed9\u4f17\u591a\u60a3\u8005\u5e26\u53bb\u5065\u5eb7\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u4e0b\u9762\u7f16\u8005\u5c06\u5bf9\u5927\u5bb6\u5173\u6ce8\u7684\u5168\u7403\u91cd\u78c5\u7684\u4e94\u5927\u6297\u75c5\u6bd2\u836f\u7269\u5217\u8868\u5e76\u7b80\u8ff0\u3002<\/span><\/p>\n

\u88682 <\/span><\/strong>\u5168\u7403<\/span><\/strong>2024<\/span><\/strong>\u5e74\u4e94\u5927\u6297\u75c5\u6bd2\u836f\u7269<\/span><\/strong><\/span><\/p>\n

\"\u5168\u7403\u672a\u6765\u6297\u75c5\u6bd2\u836f\u5e02\u573a\uff0c\u7fa4\u96c4\u9010\u9e7f\uff0c\u8c01\u6765\u95ee\u9f0e\uff1f\"<\/p>\n

\uff08\u70b9\u51fb\u56fe\u7247\u53ef\u653e\u5927\u9605\u8bfb\uff09<\/span><\/p>\n


<\/p>\n

NO1. Biktarvy<\/strong><\/strong><\/span><\/p>\n

<\/strong><\/p>\n

\u5409\u5229\u5fb7\uff08Gilead Sciences\uff09\u7684\u65b0\u836fBiktarvy\u4e8e2018\u5e742\u67088\u65e5\u6b63\u5f0f\u88ab\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\u3002\u5c06\u4e00\u79cd\u4eba\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2\u7c7b\u578b1(HIV-1)\u6574\u5408\u9176\u7684\u94fe\u8f6c\u79fb\u6291\u5236\u5242(INSTI)\u4e0e\u7ecf\u5178\u5904\u65b9\u7684\u53cc\u91cdNRTI\u9aa8\u67b6\u836f\u7269\u4e00\u8d77\u6574\u5408\u5230\u5355\u7247\u7247\u5242\u7597\u6cd5\u4e2d\u5b9e\u73b0\u4e09\u8054\u7597\u6cd5\u3002Biktarvy\u7531bictegravir\uff0850mg\uff09\u3001emtricitabine\uff08200mg\uff09\u4e0etenofoviralafenamide\uff0825mg\uff09\u4e09\u79cd\u6210\u5206\u7ec4\u6210\u3002\u4e0eGilead\u7684\u53e6\u4e00\u6b3e\u6297HIV\u836f\u7269Descovy\uff08FTC\/TAF\uff09\u76f8\u6bd4\uff0cBiktarvy\u591a\u4e86bictegravir\u8fd9\u4e2a\u6210\u5206\u3002\u8fd9\u662f\u4e00\u6b3e\u5168\u65b0\u7684\u65e0\u52a9\u63a8\uff08unboosted\uff09\u6574\u5408\u9176\u94fe\u8f6c\u79fb\u6291\u5236\u5242\uff08INSTI\uff09\u3002\u4ee5\u671f\u6539\u5584HIV\u611f\u67d3\u60a3\u8005\u7684\u6cbb\u7597\uff0c\u7b80\u5316\u7597\u6cd5\uff0c\u4e3a\u8bf8\u591aHIV\u611f\u67d3\u8005\u5e26\u6765\u65b0\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u4f5c\u4e3a\u6bcf\u65e5\u4e00\u6b21\u7684\u5355\u7247\u7247\u5242\u7597\u6cd5\uff0c\u6cbb\u7597HIV-1\u578b\u75c5\u6bd2\u7684\u611f\u67d3\uff0c\u63a7\u5236\u75c5\u60c5\u3002\u9884\u8ba12024\u5e74\uff0c\u5168\u7403\u9500\u552e\u53ef\u4ee5\u8fbe\u523060\u4ebf\u7f8e\u5143\u3002<\/span><\/p>\n


<\/strong><\/p>\n

NO2. Triumeq<\/strong>
<\/p>\n

Triumeq\u662f\u7531\u845b\u5170\u7d20\u53f2\u514bGSK\u548c\u8f89\u745ePfizer\u7684\u5408\u8d44\u516c\u53f8\u2014\u2014ViiV\u533b\u7597\u4fdd\u5065\u516c\u53f8\u5f00\u53d1\u7684\u6bcf\u65e5\u670d\u7528\u4e00\u6b21\u7684\u4e09\u5408\u4e00\u836f\u7269\uff0c\u8be5\u836f\u57fa\u4e8e\u6574\u5408\u9176\u6291\u5236\u5242Tivicay\uff08Dolutegravir\uff09\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u540c\u65f6\u8fd8\u542b\u6709\u4e24\u79cd\u6838\u82f7\u7c7b\u9006\u8f6c\u5f55\u9176\u6291\u5236\u5242 Abacavir \u548cLamivudine\uff0c2014 \u5e748 \u6708 27 \u65e5\u88abFDA\u6279\u51c6\u4e0a\u5e02\u3002Triumeq\u5728\u5e02\u573a\u4e0a\u6709\u5f88\u5f3a\u7684\u7ade\u4e89\u529b\uff1a\u4e00\u65b9\u9762\u5b83\u7ed3\u5408\u4e86\u51e0\u79cd\u4e0d\u540c\u673a\u5236\u7684\u6297HIV\u836f\u7269\u7684\u4f18\u52bf\uff0c\u8d77\u5230\u4e86\u8054\u5408\u6cbb\u7597\u7684\u6548\u679c\uff1b\u53e6\u4e00\u65b9\u9762\u5b83\u670d\u7528\u65b9\u4fbf\uff0c\u5f88\u5927\u7a0b\u5ea6\u4e0a\u589e\u52a0\u4e86\u75c5\u4eba\u670d\u836f\u7684\u987a\u5e94\u6027\uff0c\u66f4\u5bb9\u6613\u88ab\u75c5\u4eba\u63a5\u53d7\uff0c\u51cf\u5c11\u4e86\u75c5\u4eba\u4e0d\u80fd\u6309\u65f6\u6309\u5242\u91cf\u670d\u7528\u5e26\u6765\u7684\u5f71\u54cd\u3002\u6b63\u56e0\u4e3a\u5176\u4f18\u826f\u7684\u836f\u6548\uff0c\u8be5\u836f\u5728\u4e0a\u5e02\u4e00\u5e74\u540e\u5c31\u8fc8\u5165”\u91cd\u78c5\u70b8\u5f39”\u836f\u7684\u884c\u5217\uff0c2015\u5e74\u9500\u552e\u989d9.5\u4ebf\u7f8e\u5143\uff0c2016\u5e74\u8fbe\u5230\u4e8623.5\u4ebf\u7f8e\u5143\uff0c2017\u5e74\u5168\u7403\u8425\u6536\u9ad8\u8fbe31.7\u4ebf\u7f8e\u5143\uff0c\u8f832016\u5e74\u589e\u957f34.9%\uff0c\u4f4d\u5217\u5168\u7403\u6297\u75c5\u6bd2\u836f\u7269\u7684\u7b2c\u4e8c\u540d\u3002\u6309\u8fd9\u4e2a\u9500\u552e\u52bf\u5934Triumeq\u52bf\u5fc5\u662f\u672a\u67655\u5e74\u6700\u7545\u9500\u7684\u6297HIV\u836f\u7269\uff0c\u9884\u8ba1\u52302024\u5e74\uff0c\u53ef\u4ee5\u5b9e\u73b047.3\u4ebf\u7f8e\u5143\u5e02\u573a\u4efd\u989d\u3002\u5e02\u573a\u7684\u6269\u5f20\uff0c\u5f88\u5927\u7a0b\u5ea6\u4e0a\u662f\u6301\u7eed\u9700\u6c42\u7684\u9a71\u52a8\u3002<\/span><\/p>\n


<\/strong><\/p>\n

NO3. Genvoya<\/strong>
<\/p>\n

\u5409\u5229\u5fb7\u7814\u53d1\u7684\u56db\u5408\u4e00HIV\u65b0\u836fGenvoya\uff08E\/C\/E\/TAF\uff09\u4e8e2015\u5e7411\u67085\u65e5\u548c23\u65e5\u5148\u540e\u5206\u522b\u83b7\u5f97\u7f8e\u56fdFDA\u548c\u6b27\u76df\u7684\u6279\u51c6\u4e0a\u5e02\u3002Genvoya\u9002\u7528\u4eba\u7fa4\u4e3a\uff1a\u4ece\u672a\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684HIV-1\u6210\u4eba\u611f\u67d3\u8005\uff0c12\u5c81\u53ca\u4ee5\u4e0a\u4f53\u91cd\u81f3\u5c1135\u516c\u65a4\u7684HIV-1\u9752\u5c11\u5e74\u611f\u67d3\u8005\uff0c\u4ee5\u53caHIV-1\u75c5\u6bd2\u76ee\u524d\u88ab\u6291\u5236\u7684HIV-1\u6210\u4eba\u611f\u67d3\u8005\u3002Genvoya\uff08E\/C\/E\/TAF\uff09\u7597\u6548\u5ab2\u7f8eStribild\uff08E\/C\/E\/TDF\uff09\uff0c\u540c\u65f6\u80fd\u6539\u5584\u80be\u810f\u548c\u9aa8\u9abc\u53c2\u6570\uff0c\u5b89\u5168\u6027\u66f4\u9ad8\uff0c\u9002\u7528\u4eba\u7fa4\u66f4\u5e7f\uff0c\u8be5\u836f\u5c06\u6210\u4e3a\u5409\u5229\u5fb7HIV\u4e13\u8425\u6743\u4e2d\u7684\u53c8\u4e00\u5458\u731b\u5c06\uff0c\u4e5f\u662f\u5168\u7403HIV\u7fa4\u4f53\u7684\u65b0\u798f\u97f3\u3002Genvoya\uff08elvitegravir150 mg\/cobicistat 150 mg\/emtricitabine 200 mg\/tenofovir alafenamide 10 mg\uff0cE\/C\/E\/TAF\uff09\u662f\u65e5\u670d\u4e00\u6b21\u7684\u56db\u5408\u4e00\u590d\u65b9\u5355\u7247\uff0c\u8be5\u836f\u7531\u6297\u75c5\u6bd2\u836f\u7269elvitegravir(\u57c3\u66ff\u62c9\u97e6)\u3001emtricitabine(\u6069\u66f2\u4ed6\u6ee8)\u3001\u836f\u7269\u589e\u6548\u5242cobicistat\u53catenofoviralafenamide\uff08\u5bcc\u9a6c\u9178\u66ff\u8bfa\u798f\u97e6\u827e\u62c9\u915a\u80fa\uff0cTAF\uff09\u7ec4\u6210\u3002\u5409\u5229\u5fb7\uff08Gilead\uff09\u662f\u827e\u6ecb\u75c5\uff08HIV\/AIDS\uff09\u6cbb\u7597\u9886\u57df\u7684\u7edd\u5bf9\u9886\u5bfc\u8005\uff0c\u8be5\u516c\u53f8\u7814\u53d1\u7684\u56db\u5408\u4e00\u836f\u7269Stribild\uff08E\/C\/E\/TDF\uff09\u548cGenvoya\uff08E\/C\/E\/TAF\uff09\u76f8\u7ee7\u5728\u7f8e\u6b272\u5927\u5e02\u573a\u4e0a\u5e02\u540e\uff0c\u6781\u5927\u5730\u7b80\u5316\u4e86HIV\u7684\u6cbb\u7597\u7a0b\u5e8f\u30022017\u5e74\u5168\u7403\u8425\u6536\u9ad8\u8fbe37.3\u4ebf\u7f8e\u5143\uff0c\u8f832016\u5e74\u768415\u4ebf\u7f8e\u5143\u589e\u957f\u4e86148.6%\uff0c\u4f4d\u5217\u5168\u7403\u6297\u75c5\u6bd2\u836f\u7269\u7684\u7b2c\u4e09\u540d\u3002\u591a\u54c1\u79cd\u3001\u7b80\u5316\u7597\u6cd5\u7684\u8bbe\u8ba1\u548c\u5e03\u5c40\uff0c\u6309\u8fd9\u4e2a\u9500\u552e\u52bf\u5934\u5409\u5229\u5fb7\uff08Gilead\uff09\u65e0\u7591\u662f\u827e\u6ecb\u75c5\uff08HIV\/AIDS\uff09\u6cbb\u7597\u9886\u57df\u7684\u7edd\u5bf9\u9886\u5bfc\u8005\u3002<\/span><\/p>\n


<\/span><\/p>\n

NO4. Mavyret<\/strong><\/p>\n

<\/strong><\/p>\n

\"\u5168\u7403\u672a\u6765\u6297\u75c5\u6bd2\u836f\u5e02\u573a\uff0c\u7fa4\u96c4\u9010\u9e7f\uff0c\u8c01\u6765\u95ee\u9f0e\uff1f\"<\/p>\n

\u827e\u4f2f\u7ef4\uff08AbbVie\uff09\u7684\u4e19\u809d\u65b0\u836fMavyret\uff08glecaprevir\/ pibrentasvir\uff09\u4e8e2017\u5e748\u67083\u65e5\u88ab\u7f8e\u56fdFDA\u4ee5\u4f18\u5148\u5ba1\u8bc4\u4e0e\u7a81\u7834\u6027\u7597\u6cd5\u7684\u8ba4\u5b9a\u6279\u51c6\u4e0a\u5e02\uff0c\u53ef\u4ee5\u6cbb\u7597\u6240\u67096\u79cd\u4e9a\u578b\u7684\u6162\u6027\u4e19\u809d\u60a3\u8005\u3002\u4ece\u75c5\u6bd2\u672c\u8eab\u7684\u57fa\u56e0\u578b\u6765\u533a\u5206\uff0c\u4e19\u809d\u4e00\u5171\u67096\u79cd\u4e9a\u578b\u3002\u77e5\u9053\u60a3\u8005\u60a3\u6709\u54ea\u79cd\u7c7b\u578b\u7684\u4e19\u809d\uff0c\u662f\u6b63\u786e\u6cbb\u7597\u7684\u5173\u952e\u3002Mavyret\u7684\u4e0a\u5e02\uff0c\u4e5f\u662f\u5728\u6d88\u9664\u4e19\u809d\u7684\u6218\u5f79\u4e2d\uff0c\u65b0\u6dfb\u52a0\u7684\u4e00\u628a\u5168\u65b0\u7684\u6b66\u5668\u3002\u5b83\u7531\u4e24\u79cd\u4e3b\u8981\u6210\u5206\u7ec4\u6210\uff0c\u4e00\u79cd\u662fglecaprevir\uff08100mg\uff09\uff0c\u7528\u4e8e\u6291\u5236NS3\/4A\u86cb\u767d\u9176\uff1b\u53e6\u4e00\u79cd\u662fpibrentasvir\uff0840mg\uff09\uff0c\u6291\u5236NS5A\u3002\u8fd9\u6b3e\u65b0\u836f\u6bcf\u65e5\u53ea\u9700\u670d\u7528\u4e00\u6b21\uff0c\u4e14\u4e0d\u9700\u8981\u989d\u5916\u4f7f\u7528\u5229\u5df4\u97e6\u6797\uff08ribavirin\uff09\uff0c\u5c31\u80fd\u8d77\u5230\u6cdb\u57fa\u56e0\u578b\u7684\u4e19\u809d\u6cbb\u7597\u6548\u679c\u3002\u6b63\u5982\u827e\u4f2f\u7ef4\u7684\u7814\u53d1\u6267\u884c\u526f\u603b\u88c1\u517c\u9996\u5e2d\u79d1\u5b66\u5b98Michael Severino\u535a\u58eb\u6240\u8bf4\uff0c\u201cMavyret\u8ba9\u533b\u751f\u4e0e\u60a3\u8005\u6709\u4e86\u5168\u65b0\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u5b83\u9ad8\u5ea6\u6709\u6548\uff0c\u6709\u6f5c\u529b\u5728\u77ed\u77ed8\u5468\u4e4b\u5185\u6cbb\u6108\u5927\u90e8\u5206\u4e19\u809d\u60a3\u8005\uff0c\u800c\u4e0d\u7528\u8003\u8651\u75c5\u6bd2\u7684\u57fa\u56e0\u578b\u3002\u5176\u4e00\u8d2f\u7684\u627f\u8bfa\u662f\u63a8\u8fdb\u79d1\u5b66\uff0c\u6ee1\u8db3\u533b\u7597\u9700\u6c42\uff0c\u4e3a\u60a3\u8005\u5e26\u6765\u5168\u65b0\u7684\u6cbb\u6108\u624b\u6bb5\u3002\u201d\u6bcb\u5eb8\u7f6e\u7591\u5728\u5b9e\u73b0\u627f\u8bfa\u7684\u8fc7\u7a0b\u4e2d\uff0c\u8d22\u5bcc\u4e5f\u4f1a\u7d27\u968f\u800c\u6765\u3002\u770b\u6765\u5236\u836f\u4eba\u7684\u521d\u8877\u90fd\u4e0d\u8c0b\u800c\u5408\uff0c\u5e0c\u671b\u5728\u591a\u6b3e\u91cd\u78c5\u4e19\u809d\u65b0\u836f\u7684\u4f5c\u7528\u4e0b\uff0c\u4eba\u7c7b\u80fd\u591f\u65e9\u65e5\u6d88\u9664\u4e19\u809d\u8fd9\u79cd\u5f71\u54cd\u5e7f\u6cdb\u7684\u75be\u75c5\u3002<\/span><\/p>\n


<\/strong><\/p>\n

NO5.Tivicay<\/strong><\/p>\n

\"\u5168\u7403\u672a\u6765\u6297\u75c5\u6bd2\u836f\u5e02\u573a\uff0c\u7fa4\u96c4\u9010\u9e7f\uff0c\u8c01\u6765\u95ee\u9f0e\uff1f\"<\/p>\n


<\/p>\n

Tivicay\uff08dolutegravir\uff09\u7531\u845b\u5170\u7d20\u53f2\u514b\u7814\u53d1\u9500\u552e\uff0c\u4e8e2013\u5e748\u6708\u83b7\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\uff0c\u5e76\u4e8e2013\u5e7410\u6708\u83b7\u52a0\u62ff\u5927\u536b\u751f\u90e8\u6279\u51c6\uff0c\u662f\u4e00\u79cd\u4eba\u7c7b\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2\u7c7b\u578b1(HIV-1)\u6574\u5408\u9176\u94fe\u8f6c\u79fb\u6291\u5236\u5242(INSTI)\uff0c\u5e72\u6270\u827e\u6ecb\u75c5\u6bd2\u7e41\u6b96\u5fc5\u8981\u7684\u4e00\u79cd\u9176\uff0c\u4e0e\u5176\u4ed6\u6297\u9006\u8f6c\u5f55\u75c5\u6bd2\u5236\u5242\u8054\u5408\uff0c\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d\u7ed9\u836f\uff0c\u7528\u4e8e\u65e2\u5f80\u5df2\u6cbb\u7597\u8fc7\u3001\u6216\u521d\u6cbbHIV-1\u6210\u4eba\u548c12\u5c81\u53ca\u4ee5\u4e0a\u4f53\u91cd\u81f3\u5c1140\u5343\u514b\u513f\u7ae5\u611f\u67d3\u8005\u30022017\u5e74\u5168\u7403\u8425\u653618.1\u4ebf\u7f8e\u5143\uff0c\u8f832016\u5e74\u768412.9\u4ebf\u7f8e\u5143\u589e\u957f\u4e8640.2%\uff0c\u6253\u8fdb\u5168\u7403\u6297\u75c5\u6bd2\u836f\u7269\u524d\u4e94\u3002\u6839\u636e\u7f8e\u56fd\u75be\u75c5\u63a7\u5236\u548c\u9884\u9632\u4e2d\u5fc3\u7edf\u8ba1\uff1a\u5728\u7f8e\u56fd\u6bcf\u5e74\u7ea6\u67095\u4e07\u540d\u65b0\u827e\u6ecb\u75c5\u611f\u67d3\u8005\uff0c\u6bcf\u5e74\u90fd\u6709\u6570\u4ee5\u4e07\u8ba1\u7684\u4eba\u6b7b\u4e8e\u6b64\u75c7\uff0cEvaluate pharma 2018\u9884\u6d4b2024\u5e74Tivicay\u53ef\u4ee5\u8fbe\u523027\u4ebf\u7f8e\u5143\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u5168\u7403<\/span><\/strong>R&D<\/span><\/strong>\u4e94\u5927\u6297\u75c5\u6bd2\u836f\u7269\uff0c<\/span><\/strong>GSK<\/span><\/strong>\u5360\u636e<\/span><\/strong>3<\/span><\/strong>\u4e2a\uff0c\u4e34\u5e8a<\/span><\/strong>III<\/span><\/strong>\u671f<\/span><\/strong><\/p>\n

\u8868<\/span><\/strong>3 <\/span><\/strong>\u5168\u7403\u7814\u53d1\u4e2d\u7684\u4e94\u5927\u6297\u75c5\u6bd2\u836f\u7269<\/span><\/strong>
<\/p>\n

<\/strong><\/p>\n

\"\u5168\u7403\u672a\u6765\u6297\u75c5\u6bd2\u836f\u5e02\u573a\uff0c\u7fa4\u96c4\u9010\u9e7f\uff0c\u8c01\u6765\u95ee\u9f0e\uff1f\"<\/p>\n

\uff08\u70b9\u51fb\u56fe\u7247\u53ef\u653e\u5927\u9605\u8bfb\uff09<\/span><\/p>\n


<\/span><\/strong><\/span><\/p>\n

\u699c\u4e0a\u65e0\u540d\u7684\u6297\u6d41\u611f\u75c5\u6bd2\u65b0\u836f\u6216\u53ef\u91cd\u78c5\u95ee\u4e16<\/span><\/strong><\/span><\/p>\n

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\u65e5\u672c\u76d0\u91ce\u4e49\u5236\u836f(Shionogi)\u7684\u5f3a\u6548\u6d41\u611f\u836f\u7269Xofluza\uff08baloxavir marboxil\uff0cS-33188\uff09\u4e8e2018\u5e742\u670823\u65e5\u83b7\u65e5\u672c\u836f\u76d1\u52a0\u901f\u5ba1\u6279\uff0c\u6210\u529f\u5728\u65e5\u672c\u4e0a\u5e02\u7528\u4e8e\u6cbb\u7597\u7532\u578b\u548c\u4e59\u578b\u6d41\u611f\uff0c\u4e5f\u53ef\u8c13\u201c\u5e94\u65f6\u800c\u751f\u201d\u3002\u7531\u4e8e\u4e34\u5e8a\u5b9e\u9a8c\u6570\u636e\u663e\u793a\u8be5\u836f\u7269\u5728\u5f88\u591a\u65b9\u9762\u751a\u81f3\u4f18\u4e8e\u73b0\u5728\u7684\u6297\u6d41\u611f\u201c\u738b\u8005\u201d\u2014\u2014\u5965\u53f8\u4ed6\u97e6\u3002Xofluza\u662f\u4f5c\u4e3a\u4e00\u79cd\u6d41\u611f\u836f\u7269\uff085’\u5e3d\u72b6\u7ed3\u6784(CAP)\u4f9d\u8d56\u578b\u6838\u9178\u5185\u5207\u9176\u6291\u5236\u5242\uff09Cap\u4f9d\u8d56\u6027\u5185\u5207\u9176\u6291\u5236\u5242\uff0c\u5b83\u5177\u6709\u4e0e\u73b0\u6709\u836f\u7269\u795e\u7ecf\u6c28\u9178\u9176\u6291\u5236\u5242\uff0c\u5982\uff1a\u5965\u53f8\u4ed6\u97e6(\u8fbe\u83f2)\u548c\u624e\u90a3\u7c73\u97e6(\u96f7\u5c3c\u624e)\u6291\u5236\u75c5\u6bd2\u4ece\u611f\u67d3\u7ec6\u80de\u8868\u9762\u91ca\u653e\u75c5\u6bd2\u7684\u4f5c\u7528\u673a\u5236\u4e0d\u540c\uff0cXofluza\u53ef\u80fd\u662f\u901a\u8fc7\u6291\u5236\u75c5\u6bd2\u805a\u5408\u9176\u76845’\u5e3d\u72b6\u7ed3\u6784(CAP)\u4f9d\u8d56\u578b\u6838\u9178\u5185\u5207\u9176\u6d3b\u6027\u6765\u963b\u6b62\u75c5\u6bd2\u7684\u590d\u5236\uff0c\u4e5f\u5c31\u662f\u8bf4\uff0cXofluza\u5bf9\u75c5\u6bd2\u7528\u6765\u52ab\u6301\u5bbf\u4e3bmRNA\u8f6c\u5f55\u7cfb\u7edf\u4ee5\u5408\u6210\u75c5\u6bd2RNA\u7684\u673a\u5236\u8fdb\u884c\u4e86\u6709\u6548\u904f\u5236\uff0c\u53ef\u4ee5\u6709\u6548\u5730\u6291\u5236\u6d41\u611f\u75c5\u6bd2\u7684\u751f\u957f\u3002<\/span><\/p>\n

\u53e6\u5916\uff0c\u636e\u6089Xofluza\u7684\u6cbb\u7597\u975e\u5e38\u65b9\u4fbf\uff0c1\u7247\u5c31\u80fd\u62b5\u5f97\u4e0a\u5f53\u4e0b\u7684\u6807\u51c6\u7597\u6cd5\u768410\u7247\uff0c\u60a3\u8005\u53ea\u9700\u5403\u4e00\u6b21(\u4e00\u7247)\uff0c\u5c31\u80fd\u5728\u4e00\u5929\u5185\u6709\u6548\u6740\u6b7b\u6d41\u611f\u75c5\u6bd2\uff0c\u4e14\u4e0d\u53d7\u5e74\u9f84\u9650\u5236\uff08\u5305\u62ec\u513f\u7ae5\u3001\u9752\u5c11\u5e74\u4ee5\u53ca\u6210\u4eba\uff09\uff0c\u8d77\u6548\u901f\u5ea6\u8d85\u8d8a\u4efb\u4f55\u5176\u4ed6\u6297\u6d41\u611f\u836f\u7269\uff0c\u5305\u62ec\u6b64\u524d\u88ab\u75af\u72c2\u62a2\u8d2d\u7684\u5965\u53f8\u4ed6\u97e6 (\u8fbe\u83f2\uff0c\u8d77\u6548\u901a\u5e38\u898172\u5c0f\u65f6)\uff0c\u5e76\u4e14\u6709\u826f\u597d\u7684\u4f9d\u4ece\u6027\uff0c\u65e0\u7591\u53ef\u4ee5\u63d0\u9ad8\u6d41\u611f\u75c5\u6bd2\u611f\u67d3\u7684\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf\u3002<\/span>
<\/p>\n


<\/span><\/span><\/p>\n

<\/strong><\/p>\n

\"\u5168\u7403\u672a\u6765\u6297\u75c5\u6bd2\u836f\u5e02\u573a\uff0c\u7fa4\u96c4\u9010\u9e7f\uff0c\u8c01\u6765\u95ee\u9f0e\uff1f\"<\/p>\n


<\/span><\/p>\n

\u4ece\u5e02\u573a\u6765\u770b\uff0c\u7531\u4e8e\u6d41\u611f\u7684\u9891\u53d1\u6027\u4ee5\u53ca\u60a3\u8005\u57fa\u6570\u5de8\u5927\uff0c\u4e00\u4e2a\u597d\u7684\u6d41\u611f\u836f\u7269\u5f80\u5f80\u4f1a\u83b7\u5f97\u5f88\u957f\u7684\u751f\u5b58\u671f\u548c\u5f88\u9ad8\u7684\u9500\u552e\u989d\u3002\u5982\u679cXofluza\u4e00\u76f4\u5ef6\u7eed\u76ee\u524d\u4e34\u5e8a\u6570\u636e\u663e\u793a\u7684\u5353\u8d8a\u7597\u6548\uff0c\u53ef\u4ee5\u6beb\u4e0d\u5938\u5f20\u5730\u8bf4\uff1a\u5965\u53f8\u4ed6\u97e6\u7eed\u5199\u8fc7\u7684\u4f20\u5947\uff0cXofluza\u90fd\u80fd\u591f\u8d70\u4e00\u904d\uff0c\u5e76\u5c06\u767b\u4e0a\u66f4\u9ad8\u5cf0\u3002\u636e\u6089Xofluza\u9664\u5728\u65e5\u672c\u6210\u529f\u4e0a\u5e02\u5916\uff0c\u5df2\u7ecf\u5f00\u59cb\u5728\u7f8e\u56fd\u7b49\u5730\u7684\u5e02\u573a\u5e03\u5c40\uff0c\u672a\u6765\u5e02\u573a\u524d\u666f\u975e\u5e38\u5e7f\u9614\u3002\u6b64\u836f\u7684\u95ee\u4e16\u6709\u671b\u6210\u4e3a\u91cd\u78c5\u65b0\u836f\u3002\u800c\u6211\u56fd\u4f5c\u4e3a\u6d41\u611f\u9ad8\u53d1\u3001\u5e38\u53d1\u7684\u56fd\u5bb6\u4e4b\u4e00\uff0c\u6216\u8bb8\u5927\u5bb6\u4e5f\u5e0c\u671b\u65e9\u65e5\u5f15\u8fdb\u8fd9\u6837\u4f18\u79c0\u7684\u836f\u7269\uff0c\u6765\u5f25\u8865\u76ee\u524d\u6d41\u611f\u836f\u7269\u5e02\u573a\u7684\u4e0d\u8db3\u3002\u56fd\u5185\u4eff\u5236\u836f\u4f01\u4e1a\u662f\u5426\u4e5f\u53ef\u4ee5\u5f00\u59cb\u957f\u8fdc\u5e03\u5c40\uff1f<\/span> <\/span><\/p>\n


<\/strong><\/p>\n

\n

\u6392\u7248\uff1a\u96f7\u8bfa\u5c9b<\/span><\/strong><\/span><\/p>\n

\n
\n
\n
\u5e7f\u800c\u544a\u4e4b<\/section>\n<\/section>\n<\/section>\n
\n
\n

\u2299 <\/span>\u540c\u5199\u610f\u57f9\u8bad<\/span><\/strong><\/p>\n

\u5199\u610f\u8bba\u575b\u4e28\u5c0f\u5206\u5b50\u521b\u65b0\u836f\u7269\u53d1\u73b0\uff08\u9644180\u4f4d\u53c2\u4f1a\u8005\u4fe1\u606f\uff09<\/a>
<\/p>\n

\u5c0f\u5206\u5b50\u521b\u65b0\u836f\u7269\u53d1\u73b0\u2014\u2014\u7406\u8bba\u3001\u5b9e\u8df5\u3001\u8fc7\u7a0b\u4e0e\u5c55\u671b<\/a>
<\/p>\n

\u2299 \u57f9\u4f18\u57f9\u8bad<\/span><\/strong><\/p>\n

\u4f1a\u8baf|\u6539\u826f\u578b\u521b\u65b0\/505(b)(2)\u7acb\u9879\u7814\u53d1\u66a8\u4e2d\u7f8e\u53cc\u62a5\u7814\u8ba8\u4f1a\u9080\u8bf7\u51fd<\/a>
<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\"\u5168\u7403\u672a\u6765\u6297\u75c5\u6bd2\u836f\u5e02\u573a\uff0c\u7fa4\u96c4\u9010\u9e7f\uff0c\u8c01\u6765\u95ee\u9f0e\uff1f\"<\/a><\/p>\n

\n


<\/p>\n

\u836f\u4e8b\u7eb5\u6a2a\u662f\u4e00\u4e2a\u5f00\u653e\uff0c\u7531\u81ea\u613f\u8005\u7ec4\u6210\u7684\u56e2\u4f53\uff0c\u73b0\u6709\u6210\u545840\u540d\uff0c\u5206\u522b\u4e3aVoyager88\uff08\u9b4f\u5229\u519b\uff09\uff0c\u96f7\u8bfa\u5c9b\uff0c\u4e09\u5206\u8bdd\uff0cHerman\uff0c\u6885\u5e0c\uff0c\u6587\u7af9\uff0cduke\uff0cyhqqqqq\uff0c\u5360\u5c0f\u5175\uff0c\u98ce\u4e00\u6837\u7684\u5c4e\u58f3\u90ce\uff0c\u9526\u5fc3\u7ee3\u53e3\uff0cflydp511\uff0cChololate\uff0c\u4e91\u6c34\u9053\u4eba\uff0c\u9621\u4e0a\u964c\u964c\uff0c\u591a\u5df4\u80fa\uff0c\u745c\u513f\uff0cKailyn\uff0cSmall fish\uff0c\u5b50\u708e\uff0c\u514b\u683c\u83ab\uff0cVicky\uff0c\u4e07\u4e8b\u7686\u4e3a\u7a7a\uff0cPandada\uff0c\u83ab\u5306\u5306\uff0cSophia \uff0c\u4f9d\u7136\u7279\u96f7\u897f\uff0c\u5076\u9635\u96e8\uff0cAimee\uff0c\u4ed6\u5c71\u4e4b\u77f3\uff0c\u5510\u5c0f\u7396\uff0c\u96f6\u4e0b274\u2103\uff0cGloria\uff0c\u6ce2\u6ce2\uff0cBreathless\uff0cD.1\u53f7\uff0c\u80e1\u4e0d\u559c\uff0c Helen\uff0c\u843d\u843d\uff0cHERMIT\u3002\u6b22\u8fce\u6709\u5fd7\u4e4b\u58eb\u52a0\u5165\u6211\u4eec\u56e2\u961f\u3002\u6295\u7a3f\u3001\u5408\u4f5c\u3001\u52a0\u4e13\u4e1a\u7fa4\u8bf7\u52a0\u5fae\u4fe1442015666\uff0c\u836f\u4e8b\u7eb5\u6a2a\u4e8c\u5343\u4ebaQQ\u7fa422711855\u3002<\/span><\/p>\n

\n

\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u836f\u4e8b\u7eb5\u6a2a <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u5409\u5229\u5fb7\u6297\u75c5\u6bd2\u836f\u7269\u7684\u9500\u552e\u989d\u8fd1\u5e74\u867d\u7136\u6709\u6240\u4e0b\u964d\uff0c\u4f46\u9884\u8ba1\u57282024\u5e74\u7684\u6297\u75c5\u6bd2\u836f\u7269\u5e02\u573a\u4ecd\u7136\u53ef\u4ee5\u4fdd\u6301\u9886\u5148\u5730\u4f4d\u3002\u6839\u636eEval […]<\/p>\n","protected":false},"author":1,"featured_media":7585,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/7584"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=7584"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/7584\/revisions"}],"predecessor-version":[{"id":7595,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/7584\/revisions\/7595"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/7585"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=7584"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=7584"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=7584"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}