{"id":76286,"date":"2018-12-07T00:00:50","date_gmt":"2019-02-01T05:54:19","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/76286\/"},"modified":"2019-02-01T13:54:19","modified_gmt":"2019-02-01T05:54:19","slug":"1fef26662c","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/76286\/","title":{"rendered":"\u5f00\u53d1\u51fa&#8221;\u5e26\u5f00\u5173&#8221;\u7684\u65b0\u4e00\u7c7bCAR-T\u7ec6\u80de\u7597\u6cd5\uff1a\u6301\u4e45\u5e94\u7b54"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p><br  \/><\/p>\n<p style=\"margin-right: 16px;margin-bottom: 1em;margin-left: 16px;max-width: 100%;min-height: 1em;text-align: center;overflow-wrap: break-word;text-indent: 2em;color: rgb(37, 37, 37);font-family: \u5fae\u8f6f\u96c5\u9ed1, &quot;microsoft yahei&quot;, Arial, sans-serif;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"     style=\"margin-left: -2em;overflow-wrap: break-word;border-width: initial;border-style: none;border-color: initial;box-sizing: border-box !important;word-wrap: break-word !important;width: 210px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/1-1549000459-1.jpeg\" alt=\"\u5f00\u53d1\u51fa\"\u5e26\u5f00\u5173\"\u7684\u65b0\u4e00\u7c7bCAR-T\u7ec6\u80de\u7597\u6cd5\uff1a\u6301\u4e45\u5e94\u7b54\" title=\"\u5f00\u53d1\u51fa\"\u5e26\u5f00\u5173\"\u7684\u65b0\u4e00\u7c7bCAR-T\u7ec6\u80de\u7597\u6cd5\uff1a\u6301\u4e45\u5e94\u7b54\"  \/><\/p>\n<p style=\"margin-right: 16px;margin-bottom: 1em;margin-left: 16px;max-width: 100%;min-height: 1em;overflow-wrap: break-word;text-indent: 2em;color: rgb(37, 37, 37);font-family: \u5fae\u8f6f\u96c5\u9ed1, &quot;microsoft yahei&quot;, Arial, sans-serif;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff08CAR\uff09T\u7ec6\u80de\u7597\u6cd5\u4ee3\u8868\u4e86\u514d\u75ab<\/span><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u80bf\u7624<\/span><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5b66\u9886\u57df\u7684\u4e00\u79cd\u5f3a\u6709\u529b\u6cbb\u7597\u7b56\u7565\u3002\u7136\u800c\uff0c\u4e0eCAR-T\u76f8\u5173\u7684\u5371\u53ca\u751f\u547d\u7684\u6bd2\u6027\u548c\u6162\u6027B\u7ec6\u80de\u518d\u751f\u969c\u788d\uff0c\u7a81\u663e\u4e86\u63a7\u5236\u60a3\u8005\u4f53\u5185\u5de5\u7a0b\u5316T\u7ec6\u80de\u7684\u5fc5\u8981\u6027\u3002<\/span><\/p>\n<p style=\"margin-right: 16px;margin-bottom: 1em;margin-left: 16px;max-width: 100%;min-height: 1em;overflow-wrap: break-word;text-indent: 2em;color: rgb(37, 37, 37);font-family: \u5fae\u8f6f\u96c5\u9ed1, &quot;microsoft yahei&quot;, Arial, sans-serif;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u4e3a\u4e86\u521b\u9020\u5177\u6709\u957f\u671f\u8bb0\u5fc6\u53cd\u5e94\u800c\u4e0d\u4f1a\u6162\u6027\u6d88\u8017B\u7ec6\u80de\u7684CAR-T\u7ec6\u80de\u7597\u6cd5\uff0c\u6765\u81ea\u7f8e\u56fdScripps\u7814\u7a76\u6240\u5206\u652f\u673a\u6784\u52a0\u5229\u798f\u5c3c\u4e9a\u751f\u7269\u533b\u5b66\u7814\u7a76\u6240\uff08Calibr\uff09\u7684\u79d1\u5b66\u5bb6\u5df2\u5f00\u53d1\u51fa\u4e86\u5e26\u6709\u201c\u5f00\u5173\u201d\u7684CAR\uff08sCAR\uff09T\u7ec6\u80de\u5e73\u53f0\uff0c\u8be5\u5e73\u53f0\u5141\u8bb8\u4f7f\u7528\u57fa\u4e8e\u6297\u4f53\u7684\u5f00\u5173\u5bf9sCAR-T\u7ec6\u80de\u6d3b\u6027\u8fdb\u884c\u5242\u91cf\u6ef4\u5b9a\u63a7\u5236\u3002\u5728\u6ca1\u6709\u8fde\u7eed\u7684\u6297\u539f\u523a\u6fc0\u7684\u60c5\u51b5\u4e0b\uff0c\u8fd9\u79cd\u914d\u7f6e\u5c06\u5141\u8bb8sCAR-T\u7ec6\u80de\u201c\u4f11\u606f\u201d\uff0c\u8fd9\u5bf9\u4e8e\u7a33\u5065\u7684\u8bb0\u5fc6\u5f62\u6210\u662f\u5fc5\u987b\u7684\uff0c\u5e76\u7ed9\u4e88B\u7ec6\u80de\u8865\u5145\u7684\u673a\u4f1a\u3002<\/span><\/p>\n<p style=\"margin-right: 16px;margin-bottom: 1em;margin-left: 16px;max-width: 100%;min-height: 1em;overflow-wrap: break-word;text-indent: 2em;color: rgb(37, 37, 37);font-family: \u5fae\u8f6f\u96c5\u9ed1, &quot;microsoft yahei&quot;, Arial, sans-serif;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u8fd9\u6b3esCAR T\u7ec6\u80de\u7cfb\u7edf\u7531\u4e00\u79cdCD19\u5f00\u5173\uff08\u5c0f\u9f20CD19\u9776\u5411\u6027\u6297\u4f53[Fab]\u7684\u6297\u539f\u7ed3\u5408\u7247\u6bb5\u878d\u5165\u4e86\u4e00\u79cd\u80bd\u65b0\u8868\u4f4d[PNE]\uff09\u4ee5\u53ca\u4e00\u79cd\u76f8\u5e94\u7684sCAR\uff08\u5e26\u6709\u53ef\u8bc6\u522bPNE\u7684\u4e00\u79cd\u5355\u94fe\u6297\u4f53\u53ef\u53d8\u7247\u6bb5[scFv]\uff09\u7ec4\u6210\u3002CD19\u5f00\u5173\u5c06\u9776\u7ec6\u80de\u4e0a\u7684CD19\u5076\u8054\u5230PNE\u9776\u5411\u6027sCAR\u3002CD19\u5f00\u5173Fab\uff08\u7f3a\u5c11Fc\u533a\u57df\uff09\u7684\u5feb\u901f\u6e05\u9664\u5141\u8bb8\u5bf9sCAR\u523a\u6fc0\u7684\u65f6\u673a\u8fdb\u884c\u63a7\u5236\u3002\u8fdb\u4e00\u6b65\u7684\u4f18\u5316\u5de5\u4f5c\u786e\u5b9a\u4e86\u4e00\u79cdIgG4m\u94f0\u94fe\u548c\u4e00\u79cd\u91ce\u751f\u578bCD3\u80de\u5185\u7ed3\u6784\u57df\u5bf9\u4e8esCAR T\u7ec6\u80de\u7684\u6301\u4e45\u6027\u548c\u6269\u589e\u662f\u81f3\u5173\u91cd\u8981\u7684\u3002<\/span><\/p>\n<p style=\"margin-right: 16px;margin-bottom: 1em;margin-left: 16px;max-width: 100%;min-height: 1em;overflow-wrap: break-word;text-indent: 2em;color: rgb(37, 37, 37);font-family: \u5fae\u8f6f\u96c5\u9ed1, &quot;microsoft yahei&quot;, Arial, sans-serif;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5728\u5c0f\u9f20\u6a21\u578b\u4e0a\uff0c\u7814\u7a76\u4eba\u5458\u8bc1\u5b9e\u4e86sCAR-T\u7684\u6297<\/span><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u80bf\u7624<\/span><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u6d3b\u6027\uff0c\u540c\u65f6\u6d88\u9664\u4e86\u957f\u671f\u6301\u4e45\u7684B\u7ec6\u80de\u518d\u751f\u969c\u788d\u3002\u6b64\u5916\uff0c\u7814\u7a76\u4eba\u5458\u8fd8\u8bc1\u5b9e\uff0c\u901a\u8fc7\u5468\u671f\u6027\u7684\u201c\u5f00\/\u5173\u201d\u7ed9\u836f\uff0c\u53ef\u5c06sCAR-T\u5e73\u53f0\u7684\u529f\u80fd\u53ef\u9006\u6027\u4e0e\u201c\u4f11\u606f\u671f\u201d\u7ed3\u5408\u4e3a\u4e00\u4f53\uff0c\u8fd9\u79cd\u65b9\u6848\u4e0d\u4ec5\u5141\u8bb8\u901a\u8fc7\u8fed\u4ee3\u8017\u5c3d\u548c\u91cd\u65b0\u589e\u6b96\u6765\u63a7\u5236B\u7ec6\u80de\u7fa4\u4f53\uff0c\u800c\u4e14\u7ed9\u836f\u5468\u671f\u4e4b\u95f4\u7684\u201c\u4f11\u606f\u201d\u671f\u662f\u8bf1\u5bfc\u8bb0\u5fc6\u548csCAR T\u7ec6\u80de\u6269\u589e\u7684\u5173\u952e\u3002\u6700\u7ec8\uff0c\u8fd9\u79cd\u5468\u671f\u6027\u5f00\u5173\u63a7\u5236\u53ef\u4e3a\u4f53\u5185\u3001\u6309\u9700\u6269\u589esCAR T\u7ec6\u80de\u8bf1\u5bfc\u4e00\u4e2a\u5065\u58ee\u7684\u4e2d\u592e\u8bb0\u5fc6\u7fa4\u4f53\u3002<\/span><\/p>\n<p style=\"margin-right: 16px;margin-bottom: 1em;margin-left: 16px;max-width: 100%;min-height: 1em;overflow-wrap: break-word;text-indent: 2em;color: rgb(37, 37, 37);font-family: \u5fae\u8f6f\u96c5\u9ed1, &quot;microsoft yahei&quot;, Arial, sans-serif;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">CAR-T\u7ec6\u80de\u7684\u8868\u578b\u547d\u8fd0\uff0c\u51b3\u5b9a\u4e86\u5b83\u4eec\u5728\u4e34\u5e8a\u4e0a\u7684\u6cbb\u7597\u6548\u679c\uff0c\u5176\u4e2dTCM\u8868\u578b\u5df2\u88ab\u8bc1\u660e\u5bf9\u4e8e\u6025\u6027\u6dcb\u5df4\u7ec6\u80de<\/span><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u767d\u8840\u75c5<\/span><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u60a3\u8005\u5177\u6709\u6301\u7eed\u7684\u7f13\u89e3\u4f5c\u7528\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u8bc1\u660esCAR T\u7ec6\u80de\u5e73\u53f0\u53ef\u5728\u6b21\u7ea7\u6dcb\u5df4\u7ec4\u7ec7\u5185\u4ea7\u751f\u4e00\u4e2a\u6301\u4e45\u7684sCAR+ CD8+ TCM\u7fa4\u4f53\uff0c\u4ece\u800c\u5bfc\u81f4\u6301\u4e45\u7684\u6297<\/span><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u80bf\u7624<\/span><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u5e94\u7b54\u3002\u4f11\u606f\u671f\uff08\u5373sCAR T\u7ec6\u80de\u4e0d\u6d3b\u8dc3\u7684\u65f6\u671f\uff09\u5bf9\u4e8esCAR+ CD8+ TCM\u4e9a\u7fa4\u7684\u5f62\u6210\u53caB\u7ec6\u80de\u7684\u8865\u5145\u81f3\u5173\u91cd\u8981\uff0c\u800c\u8fd9\u4e9b\u6700\u7ec8\u6709\u671b\u5728\u4e34\u5e8a\u4e0a\u5efa\u7acbsCAR T\u7ec6\u80de\u4ea7\u54c1\u7684\u826f\u597d\u7597\u6548\u548c\u5b89\u5168\u6027\u3002<\/span><\/p>\n<p style=\"margin-right: 16px;margin-bottom: 1em;margin-left: 16px;max-width: 100%;min-height: 1em;overflow-wrap: break-word;text-indent: 2em;color: rgb(37, 37, 37);font-family: \u5fae\u8f6f\u96c5\u9ed1, &quot;microsoft yahei&quot;, Arial, sans-serif;font-size: 16px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 15px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u8fd9\u9879\u7814\u7a76\u6210\u679c\u5df2\u4e8e\u6700\u8fd1\u53d1\u8868\u4e8e\u300a\u7f8e\u56fd\u79d1\u5b66\u9662\u9662\u62a5\u300b\uff08PNAS\uff09\u3002<\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size: 16px;white-space: normal;max-width: 100%;color: rgb(51, 51, 51);letter-spacing: 0.544px;text-align: justify;background-color: rgb(255, 255, 255);font-family: \u5fae\u8f6f\u96c5\u9ed1;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\"    style=\"margin-right: auto;margin-left: auto;max-width: 100%;box-sizing: border-box;font-family: -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;letter-spacing: 0.544px;line-height: 25.6px;width: 592px;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box;font-family: Arial, sans-serif;letter-spacing: 0.544px;line-height: 27.2px;border-width: 0px;border-style: none;border-color: initial;word-wrap: break-word !important;\">\n<section class=\"\" style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;font-family: -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;font-size: 17px;line-height: 27.2px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(0, 176, 80);font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\">\u626b\u4e00\u626b \u5173\u6ce8\u6211\u4eec\uff01<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><br style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"  \/><\/section>\n<p style=\"font-size: 16px;white-space: normal;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);font-family: Arial, sans-serif;letter-spacing: 0.544px;text-align: justify;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<p><br  \/><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff08CAR\uff09T\u7ec6\u80de\u7597\u6cd5\u4ee3\u8868\u4e86\u514d\u75ab\u80bf\u7624\u5b66\u9886\u57df\u7684\u4e00\u79cd\u5f3a\u6709\u529b\u6cbb\u7597\u7b56\u7565\u3002\u7136\u800c\uff0c\u4e0eCAR-T\u76f8\u5173\u7684\u5371\u53ca\u751f\u547d\u7684\u6bd2 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":76287,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/76286"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=76286"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/76286\/revisions"}],"predecessor-version":[{"id":76289,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/76286\/revisions\/76289"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/76287"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=76286"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=76286"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=76286"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}