{"id":7704,"date":"2018-06-08T01:00:00","date_gmt":"2018-07-27T09:26:52","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/2018\/07\/27\/%e7%88%b1%e6%83%85%e4%bf%9d%e9%b2%9c%e5%89%82-%e7%bc%a9%e5%ae%ab%e7%b4%a0%e4%b8%8d%e4%b8%ba%e4%ba%ba%e7%9f%a5%e7%9a%84%e4%bd%9c%e7%94%a8%e5%92%8c%e4%b8%bb%e8%a6%81%e6%9d%a5\/"},"modified":"2018-07-27T17:26:53","modified_gmt":"2018-07-27T09:26:53","slug":"%e7%88%b1%e6%83%85%e4%bf%9d%e9%b2%9c%e5%89%82-%e7%bc%a9%e5%ae%ab%e7%b4%a0%e4%b8%8d%e4%b8%ba%e4%ba%ba%e7%9f%a5%e7%9a%84%e4%bd%9c%e7%94%a8%e5%92%8c%e4%b8%bb%e8%a6%81%e6%9d%a5","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/7704\/","title":{"rendered":"\u201c\u7231\u60c5\u4fdd\u9c9c\u5242\u201d—\u7f29\u5bab\u7d20\u4e0d\u4e3a\u4eba\u77e5\u7684\u4f5c\u7528\u548c\u4e3b\u8981\u6765\u6e90"},"content":{"rendered":"
\n

\u6587\uff1aHERMIT<\/span><\/h3>\n


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\"\u201c\u7231\u60c5\u4fdd\u9c9c\u5242\u201d---\u7f29\u5bab\u7d20\u4e0d\u4e3a\u4eba\u77e5\u7684\u4f5c\u7528\u548c\u4e3b\u8981\u6765\u6e90\"<\/section>\n
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\u7f29\u5bab\u7d20\u7684\u4f5c\u7528<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n


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1953<\/span>\u5e74\u521d<\/span>du Vigneaud<\/span>\u548c<\/span>Tuppyd<\/span>\u7b49\u79d1\u5b66\u5bb6\u7b2c\u4e00\u6b21\u6d4b\u5b9a\u51fa\u4e86\u7f29\u5bab\u7d20\u7684\u4e5d\u4e2a\u6c28\u57fa\u9178\u5e8f\u5217<\/span>[1]<\/span><\/sup>\uff0c\u5176\u5e8f\u5217\u4e3a\uff1a<\/span>Cys<\/span>-Tyr-Ile-Gln-Asn-Cys<\/span>-Pro-Leu-Gly-NH2<\/sub><\/span>\uff0c\u5176\u4e2d\u4e24\u4e2a\u534a\u80f1\u6c28\u9178\u7684\u5def\u57fa\u73af\u5316\u5f62\u6210\u4e00\u4e2a\u4e8c\u786b\u952e\u7ed3\u6784\uff08\u7ed3\u6784\u5f0f\u89c1\u56fe<\/span>1<\/span>\uff09\u3002\u7f29\u5bab\u7d20\u7684\u7ed3\u6784\u548c\u6297\u5229\u5c3f\u6fc0\u7d20\uff08<\/span>Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Leu-Gly-NH2<\/sub><\/span>\uff09\u975e\u5e38\u76f8\u4f3c\u3002<\/span><\/p>\n


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\"\u201c\u7231\u60c5\u4fdd\u9c9c\u5242\u201d---\u7f29\u5bab\u7d20\u4e0d\u4e3a\u4eba\u77e5\u7684\u4f5c\u7528\u548c\u4e3b\u8981\u6765\u6e90\"<\/p>\n


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\u56fe1 \u7f29\u5bab\u7d20\u7684\u5316\u5b66\u7ed3\u6784\u56fe<\/span><\/strong><\/p>\n

Scheme 1. The chemical structureof oxytocin<\/span><\/strong><\/p>\n

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\uff08<\/span>1<\/span>\uff09\u5f15\u4ea7\uff1b<\/span><\/span><\/p>\n


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\uff08<\/span>2<\/span>\uff09\u52a0\u5f3a\u5b50\u5bab\u6536\u7f29\uff1a\u5728\u5206\u5a29\u8fc7\u7a0b\u4e2d\uff0c\u5982\u5b50\u5bab\u6536\u7f29\u4e4f\u529b\u65f6\uff0c\u9700\u52a0\u5f3a\u5bab\u7f29\uff1b<\/span><\/span><\/p>\n


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\u5bf9\u4e8e\u52a8\u7269\u7684\u5fc3\u8840\u7ba1\u7cfb\u7edf\uff0c\u7f29\u5bab\u7d20\u4e5f\u6709\u4e00\u5b9a\u7684\u4f5c\u7528\u3002\u6709\u7814\u7a76\u6307\u51fa\uff0c\u9759\u8109\u6ce8\u5165\u7f29\u5bab\u7d20\u53ef\u4f7f\u5927\u9f20\u8840\u538b\u964d\u4f4e\u548c\u5fc3\u7387\u51cf\u6162<\/span>[4]<\/span><\/sup>\u3002\u8fd8\u6709\u7814\u7a76\u8868\u660e\uff0c\u7f29\u5bab\u7d20\u4f5c\u4e3a\u7ec6\u80de\u751f\u957f\u548c\u5206\u5316\u7684\u8bf1\u5bfc\u5242<\/span>,<\/span>\u5bf9\u4e73\u817a\u764c\u7ec6\u80de\u5177\u6709\u6297\u589e\u6b96\u7684\u4f5c\u7528\uff0c\u5176\u4f5c\u7528\u662f\u901a\u8fc7\u4e0e\u4fc3\u7532\u72b6\u817a\u6fc0\u7d20\u53d7\u4f53<\/span>(OTR)<\/span>\u7684\u7ed3\u5408\u5b9e\u73b0\u7684<\/span>[<\/span><\/sup>5-6<\/span><\/sup>]<\/span><\/sup>\u3002<\/span><\/span><\/p>\n

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\u7f29\u5bab\u7d20\u6291\u5236\u963f\u7247\u4f9d\u8d56\u548c\u8010\u53d7\u3002\u7f29\u5bab\u7d20\u53ef\u51cf\u8f7b\u52a8\u7269\u5bf9\u5417\u5561\u3001\u6d77\u6d1b\u56e0\u3001\u03b2<\/span>–<\/span>\u5185\u5561\u80bd\u548c\u8111\u5561\u80bd\u7684\u8010\u53d7\u7a0b\u5ea6\u3002\u6709\u5b9e\u9a8c\u663e\u793a\uff0c\u7ed9\u5927\u9f20\u6ce8\u5c04\u7f29\u5bab\u7d20\u540e\uff0c\u5927\u9f20\u5bf9\u6d77\u6d1b\u56e0\u7684\u4e3b\u52a8\u670d\u836f\u91cf\u51cf\u5c11\u3002\u7f29\u5bab\u7d20\u4e0d\u4ec5\u6291\u5236\u5417\u5561\u8010\u53d7\u7684\u5f62\u6210\uff0c\u8fd8\u53ef\u5f71\u54cd\u52a8\u7269\u5bf9\u5417\u5561\u7684\u4f9d\u8d56\u3002<\/span>McGregor[7]<\/sup><\/span>\u7b49\u4eba\u901a\u8fc7\u7814\u7a76\u4e5f\u8868\u660e\uff0c\u7f29\u5bab\u7d20\u662f\u4e00\u79cd\u6f5c\u5728\u7684\u53ef\u6cbb\u7597\u6bd2\u54c1\u6210\u763e\u7684\u836f\u7269\u3002<\/span><\/span><\/p>\n

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\u7f29\u5bab\u7d20\u4e0e\u6bcd\u6027\u884c\u4e3a\u7684\u5f62\u6210\u6709\u8054\u7cfb<\/span>[8-10]<\/span><\/sup>\u3002\u5206\u5a29\u671f\u95f4\u8111\u810a\u6db2\u4e2d\u7f29\u5bab\u7d20\u7684\u6d53\u5ea6\u4f1a\u589e\u9ad8<\/span>,<\/span>\u4ece\u800c\u5bf9\u6bcd\u6027\u884c\u4e3a\u4ea7\u751f\u4e3b\u8981\u5f71\u54cd\u3002\u76ee\u524d\u6709\u4e24\u7c7b\u5b9e\u9a8c\u652f\u6301\u8fd9\u4e2a\u7ed3\u8bba\uff0c\u7b2c\u4e00\u7c7b\u5b9e\u9a8c\u662f\u5c06\u7f29\u5bab\u7d20\u6ce8\u5165\u672a\u4ea4\u914d\u8fc7\u7684\u8001\u9f20\u6216\u672a\u598a\u5a20\u7684\u7f8a\u7684\u8111\u5ba4\u540e\u5b83\u4eec\u4f1a\u8fc5\u901f\u4ea7\u751f\u6bcd\u5b50\u4eb2\u8fd1\u548c\u54fa\u80b2\u540e\u4ee3\u7b49\u6bcd\u6027\u884c\u4e3a\uff1b\u7b2c\u4e8c\u7c7b\u5b9e\u9a8c\u662f\u5f53\u5c06\u7f29\u5bab\u7d20\u6297\u4f53\u6ce8\u5165\u6bcd\u4eb2\u7684\u4f53\u5185\u65f6\u5b83\u4eec\u4f1a\u62d2\u7edd\u54fa\u80b2\u5176\u540e\u4ee3\u3002\u8fd8\u6709\u5176\u5b83\u5f88\u591a\u9488\u5bf9\u4e8e\u54fa\u4e73\u52a8\u7269\u7684\u7814\u7a76\u4e5f\u8bc1\u5b9e\u4e86\u540c\u6837\u7684\u7ed3\u679c\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

\u7f29\u5bab\u7d20\u5bf9\u52a8\u7269\u5176\u4ed6\u793e\u4f1a\u884c\u4e3a\u65b9\u9762\u7684\u5f71\u54cd\u3002<\/span>Calcagnoli[11]<\/sup><\/span>\u7b49\u79d1\u5b66\u5bb6\u901a\u8fc7\u5c0f\u9f20\u8111\u5185\u5ba4\u7ed9\u836f\u7f29\u5bab\u7d20\uff0c\u7136\u540e\u5bf9\u5c0f\u9f20\u7684\u884c\u4e3a\u8fdb\u884c\u89c2\u5bdf\u53d1\u73b0\uff0c\u7f29\u5bab\u7d20\u53ef\u4ee5\u51cf\u5c11\u5c0f\u9f20\u7684\u653b\u51fb\u6027\uff0c\u7279\u522b\u662f\u53ef\u4ee5\u964d\u4f4e\u90a3\u4e9b\u653b\u51fb\u6027\u5f3a\u7684\u8001\u9f20\u7684\u653b\u51fb\u6027\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u7ed9\u8001\u9f20\u6ce8\u5c04\u7f29\u5bab\u7d20\u53d7\u4f53\u62ee\u6297\u5242\u540e\u53d1\u73b0\uff0c\u90a3\u4e9b\u6709\u653b\u51fb\u6027\u7684\u8001\u9f20\u53d8\u5f97\u66f4\u6709\u653b\u51fb\u6027\uff0c\u4f46\u4e0d\u80fd\u4f7f\u90a3\u4e9b\u6e29\u548c\u7684\u8001\u9f20\u53d8\u5f97\u6709\u653b\u51fb\u6027\u3002\u8fd9\u4e9b\u79d1\u5b66\u5bb6\u901a\u8fc7\u4e00\u7cfb\u5217\u7684\u5b9e\u9a8c\u63a8\u6d4b\uff0c\u7f29\u5bab\u7d20\u4ee5\u540e\u6709\u671b\u6cbb\u7597\u4e00\u4e9b\u53cd\u793e\u4f1a\u6027\u4eba\u683c\u969c\u788d\uff0c\u5b64\u72ec\u75c7\u7b49\u7cbe\u795e\u75be\u75c5\u3002<\/span>Gurrieri[12]<\/sup><\/span>\u7b49\u7684\u7814\u7a76\u4e5f\u8868\u660e\u7f29\u5bab\u7d20\u548c\u5b64\u72ec\u75c7\u7f3a\u5931\u5b58\u5728\u4e00\u5b9a\u7684\u5173\u7cfb\u3002<\/span>Poulin[13]<\/sup><\/span>\u7b49\u7814\u7a76\u8868\u660e\uff0c\u7f29\u5bab\u7d20\u80fd\u51cf\u5c11\u4eba\u4eec\u7684\u7126\u8651\uff0c\u8ba9\u4eba\u4eec\u66f4\u70ed\u8877\u4e8e\u5e2e\u52a9\u4ed6\u4eba\uff0c\u66f4\u6709\u7231\u5fc3\uff0c\u4f7f\u4eba\u4fdd\u6301\u8eab\u4f53\u5065\u5eb7\u3002<\/span>Sasayama<\/span>\u7b49<\/span>[14]<\/span><\/sup>\u7684\u7814\u7a76\u4e5f\u8868\u660e\uff0c\u7cbe\u795e\u5206\u88c2\u60a3\u8005\u548c\u6291\u90c1\u75c7\u60a3\u8005\u8111\u810a\u9ad3\u6db2\u4e2d\u7684\u7f29\u5bab\u7d20\u6c34\u5e73\u975e\u5e38\u4f4e\uff0c\u60a3\u8005\u7684\u4e25\u91cd\u7a0b\u5ea6\u4e0e\u7f29\u5bab\u7d20\u7684\u4f4e\u6d53\u5ea6\u5448\u6b63\u76f8\u5173\u7684\u5173\u7cfb\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

\u7f29\u5bab\u7d20\u5bf9\u4fc3\u80be\u4e0a\u817a\u76ae\u8d28\u6fc0\u7d20\u548c\u4fc3\u7532\u72b6\u817a\u7d20\u5206\u6ccc\u548c\u52a8\u7269\u7684\u6027\u884c\u4e3a\u5747\u6709\u4e00\u5b9a\u7684\u5f71\u54cd<\/span>[15-17]<\/span><\/sup>\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

\u7f29\u5bab\u7d20\u4e3b\u8981\u5728\u4e0b\u4e18\u8111\u5ba4\u65c1\u6838<\/span>(paraventricular,PVN)<\/span>\u548c\u89c6\u4e0a\u6838<\/span>(supraoptic nucleus, SON)<\/span>\u5408\u6210\u3002\u7f29\u5bab\u7d20\u5728\u52a8\u7269\u4f53\u5185\u7684\u534a\u8870\u671f\u4ec5\u4e3a<\/span>3<\/span>\uff5e<\/span>10<\/span>\u5206\u949f\uff0c\u5728\u9ad8\u6d53\u5ea6\u65f6\u5b83\u7684\u534a\u8870\u671f\u66f4\u77ed\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

\u7f29\u5bab\u7d20\u795e\u7ecf\u5143\u9664\u96c6\u4e2d\u5206\u5e03\u5728\u4e0b\u4e18\u8111\u7684\u4e0b\u4e18\u8111\u5ba4\u65c1\u6838\u548c\u89c6\u4e0a\u6838\u5916\uff0c\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf<\/span>(centralnervous system, CNS)<\/span>\u7684\u5176\u5b83\u533a\u57df\u4e5f\u6709\u7f29\u5bab\u7d20\u795e\u7ecf\u5143\uff0c\u5982\u89c6\u524d\u533a\u3001\u524d\u8054\u5408\u526f\u6838\u3001\u4e0b\u4e18\u8111\u524d\u533a\u548c\u5916\u4fa7\u533a\u3001\u7b2c\u4e09\u8111\u5ba4\u5468\u56f4\u3001\u6d77\u9a6c\u3001\u674f\u4ec1\u6838\u3001\u4e2d\u9694\u3001\u9ed1\u8d28\u3001\u8111\u5e72\u548c\u810a\u9ad3\u7b49\u3002\u4e0b\u4e18\u8111\u5ba4\u65c1\u6838\u548c\u89c6\u4e0a\u6838\u7684\u7f29\u5bab\u7d20\u795e\u7ecf\u5143\u53d1\u51fa\u7684\u7ea4\u7ef4\u6295\u5c04\u5230\u795e\u7ecf\u5782\u4f53\u7684\u8840\u7ba1\u5468\u56f4\u3001\u6b63\u4e2d\u9686\u8d77\u3001\u5ba4\u5468\u5668\u5b98\u3001\u7a79\u9686\u4e0b\u5668\u5b98\u548c\u677e\u679c\u4f53\u7b49\u3002\u53e6\u5916\uff0c\u4e00\u4e9b\u5916\u5468\u7ec4\u7ec7\u5668\u5b98\u4e5f\u53ef\u5408\u6210\u548c\u5206\u6ccc\u7f29\u5bab\u7d20\uff0c\u5982\u5b50\u5bab\u3001\u80ce\u819c\u3001\u7f8a\u819c\u3001\u9ec4\u4f53\u3001\u80be\u4e0a\u817a\u3001\u80f8\u817a\u3001\u80f0\u817a\u3001\u777e\u4e38\u3001\u5fc3\u810f\u7b49<\/span>[18]<\/span><\/sup>\u3002\u7f29\u5bab\u7d20\u795e\u7ecf\u5143\u5206\u5e03\u5982\u6b64\u5e7f\u6cdb\uff0c\u53ef\u4ee5\u63a8\u65ad\uff0c\u7f29\u5bab\u7d20\u7684\u4f5c\u7528\u4e5f\u4f1a\u968f\u7740\u5bf9\u5176\u4e0d\u65ad\u7684\u7814\u7a76\u800c\u4e0d\u65ad\u6709\u65b0\u7684\u53d1\u73b0\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

\u6211\u56fd\u4eba\u7528\u836f\u6bcf\u5e74\u7684\u9700\u6c42\u91cf\u8f83\u5c11\uff0c\u4e3b\u8981\u662f\u4f5c\u4e3a\u517d\u7528\u836f\uff0c\u7279\u522b\u662f\u51fa\u53e3\u5230\u755c\u7267\u4e1a\u53d1\u8fbe\u56fd\u5bb6\u7684\u517d\u7528\u539f\u6599\u836f\u3002\u968f\u7740\u7f29\u5bab\u7d20\u65b0\u4f5c\u7528\u7684\u4e0d\u65ad\u53d1\u73b0\uff0c\u9700\u6c42\u91cf\u5c06\u4f1a\u8d8a\u6765\u8d8a\u591a\u3002<\/span><\/p>\n

<\/span><\/h3>\n

<\/p>\n

<\/section>\n
\"\u201c\u7231\u60c5\u4fdd\u9c9c\u5242\u201d---\u7f29\u5bab\u7d20\u4e0d\u4e3a\u4eba\u77e5\u7684\u4f5c\u7528\u548c\u4e3b\u8981\u6765\u6e90\"<\/section>\n
\n
\n

\u7f29\u5bab\u7d20\u7684\u751f\u7269\u63d0\u53d6<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n

<\/span><\/h3>\n

<\/span><\/span>
<\/h3>\n

\u76ee\u524d\u7f29\u5bab\u7d20\u7684\u751f\u4ea7\u4e3b\u8981\u901a\u8fc7\u751f\u7269\u63d0\u53d6\u6cd5\u3002\u751f\u7269\u63d0\u53d6\u6cd5\u4e2d\u4e3b\u8981\u7684\u76f8\u5173\u6742\u8d28\u662f\u52a0\u538b\u7d20\uff0c\u7f29\u5bab\u7d20\u548c\u52a0\u538b\u7d20\u90fd\u4e3a\u73af\u72b6\u4e5d\u80bd\uff0c\u4f46\u662f\u52a0\u538b\u7d20\u78b1\u6027\u8f83\u5f3a\u3002\u5c06\u542b\u6709\u52a0\u538b\u7d20\u6742\u8d28\u7684\u5782\u4f53\u540e\u53f6\u63d0\u53d6\u6db2\u901a\u5165\u4eba\u9020\u6cb8\u77f3\u7684\u67f1\u5b50\u65f6\uff0c\u52a0\u538b\u7d20\u7edd\u5927\u90e8\u5206\u88ab\u5438\u9644\uff0c\u800c\u7f29\u5bab\u7d20\u901a\u8fc7\u6cb8\u77f3\u67f1\u800c\u6d41\u51fa\u3002\u6d41\u51fa\u7684\u7f29\u5bab\u7d20\u6eb6\u6db2\uff0c\u7528\u7682\u571f\u5904\u7406\u540e\uff0c\u53ef\u5f97\u8f83\u7eaf\u7684\u7f29\u5bab\u7d20\u3002\u4ece\u5782\u4f53\u540e\u53f6\u63d0\u53d6\u7f29\u5bab\u7d20\u7684\u4e00\u822c\u5de5\u827a\u5982\u4e0b\uff1a\u5c06\u5782\u4f53\u540e\u53f6\u5e72\u7c89\u548c\u77f3\u82f1\u7c89\u7ea6<\/span>3:1<\/span>\u52a0\u5165\u5230\u9002\u91cf\u7684\u84b8\u998f\u6c34\u4e2d\uff0c\u5728\u7403\u78e8\u4e2d\u7814\u78e8\u63d0\u53d6\uff0c\u7136\u540e\u79bb\u5fc3\uff0c\u6536\u96c6\u4e0a\u5c42\u6e05\u6db2\u3002\u5c06\u5904\u7406\u597d\u7684\u4eba\u9020\u6cb8\u77f3\uff0c\u52a0\u5165<\/span>0.2%<\/span>\u5de6\u53f3\u7684\u918b\u9178\u6eb6\u6db2\uff0c\u6405\u62cc\u5747\u5300\u540e\u88c5\u5165\u5230\u4ea4\u6362\u67f1\u4e2d\uff0c\u5f85\u4ea4\u6362\u67f1\u4e2d\u7684\u918b\u9178\u6db2\u4e0b\u964d\u5230\u6cb8\u77f3\u8868\u9762\u4ee5\u4e0b\u5c11\u8bb8\u8ddd\u79bb\u65f6\uff0c\u5173\u6389\u6d41\u901f\uff0c\u52a0\u5165\u63d0\u53d6\u6db2\uff0c\u7136\u540e\u4ee5\u9002\u5f53\u7684\u6d41\u901f\u8ba9\u63d0\u53d6\u6db2\u901a\u8fc7\u67f1\u5b50\uff0c\u76f4\u5230\u4e0a\u5b8c\u6240\u6709\u7684\u63d0\u53d6\u6db2\uff0c\u5f53\u67f1\u4e2d\u5f00\u59cb\u6d41\u51fa\u767d\u8272\u6d51\u6d4a\u6db2\u65f6\uff0c\u7acb\u5373\u6536\u96c6\u3002\u63d0\u53d6\u6db2\u4e0a\u5b8c\u540e\uff0c\u7ee7\u7eed\u52a0\u5165\u84b8\u998f\u6c34\uff0c\u4f9d\u7136\u6536\u96c6\u767d\u8272\u6df7\u6d4a\u6db2\u76f4\u5230\u8fd9\u79cd\u6df7\u6d4a\u6db2\u6536\u96c6\u5b8c\u5168\u3002\u6536\u96c6\u6db2\u7528\u51b0\u918b\u9178\u8c03\u6210\u9178\u6027\uff08<\/span>pH<\/span>\u7ea6\u4e3a<\/span>3<\/span>\uff09\uff0c\u51b7\u85cf\u8fc7\u591c\u540e\u8fc7\u6ee4\u3002\u7136\u540e\u5c06\u6ee4\u6db2\u5728\u6405\u62cc\u4e0b\uff0c\u52a0\u5165\u4e8b\u5148\u5904\u7406\u597d\u7684<\/span>10%<\/span>\u7682\u571f\u6d46\uff0c\u4e0d\u505c\u6405\u62cc\u4f7f\u7f29\u5bab\u7d20\u5b8c\u5168\u5438\u9644\u5230\u7682\u571f\u4e0a\u3002\u5438\u9644\u5b8c\u5168\u540e\uff0c\u518d\u7528<\/span>1%<\/span>\u918b\u9178\u6eb6\u6db2\u5c06\u7f29\u5bab\u7d20\u6d17\u8131\u4e0b\u6765\u3002\u68c0\u6d4b\u7f29\u5bab\u7d20\u7684\u7eaf\u5ea6\uff0c\u5982\u679c\u672a\u8fbe\u5230\u8981\u6c42\uff0c\u5219\u7528\u7682\u571f\u591a\u91cd\u590d\u51e0\u6b21\u5438\u9644\u4e0e\u6d17\u8131\u7684\u8fc7\u7a0b\uff0c\u76f4\u5230\u68c0\u6d4b\u5408\u683c\u5373\u5f97\u7f29\u5bab\u7d20\u6eb6\u6db2\u3002<\/span><\/span><\/p>\n

 <\/span><\/p>\n

\u63d0\u53d6\u6d41\u7a0b\u56fe\u5982\u4e0b\uff1a<\/span><\/p>\n

<\/span>
<\/p>\n

\"\u201c\u7231\u60c5\u4fdd\u9c9c\u5242\u201d---\u7f29\u5bab\u7d20\u4e0d\u4e3a\u4eba\u77e5\u7684\u4f5c\u7528\u548c\u4e3b\u8981\u6765\u6e90\"<\/p>\n


<\/p>\n


<\/p>\n

\u56fe2 \u7f29\u5bab\u7d20\u7684\u63d0\u53d6\u6d41\u7a0b\u56fe<\/span><\/strong><\/p>\n

 <\/p>\n

 <\/p>\n

\u53c2\u8003\u6587\u732e<\/span><\/p>\n

[1]duVigneaud V, Ressler C, Trippett S. The sequence of amino acids in oxytocin,with a proposal for the structure of oxytocin . J. Biol. Chem. 1953-12, 205(2): 949\u201357<\/span><\/p>\n

[2]Meyer,Dixie. Selective  Serotonin  Reuptake Inhibitors and Their Effects onRelationship Satisfaction. The Family Journal. 2007, 15 (4): 392<\/span>\u2013<\/span>397<\/span><\/span><\/p>\n

[3]AsadM,Shewade D G,Kounaravelou K,etal.Gastric antisecretory and antiulceractivty ofoxytoncin in rats and guineapig[J].Life Sci, 2001,70(1):17-24<\/span><\/p>\n

[4]PeterssonM. Cardiovascular effects of oxytocin [J].Prog Brain Res,2002,139(7):281-288<\/span><\/p>\n

[5]SkerjancIS.Cardiac and skeletal muscle development in P19 embryonal carcinomacells[J].Trends Cardiovasc Med. 1999,9(4):139-143<\/span><\/p>\n

[6]Cassonl P,Sapino A,Stella A,etal,Presence and significance of oxytocinreceptors in human neuroblastomas and glial tumor[J].Int Cancer1998,77(3):695-700<\/span><\/p>\n

[7] McGregor, I.S. and M.T. Bowen, Breaking theloop:Oxytocin as a potential treatment for drug addiction. Horm. Behav., 2012,61(3):331-339<\/span><\/p>\n

[8]Peltola Mikko, J., et al.,Motherhood and oxytocin receptor genetic variation are associated withselective changes in electrocortical responses to infant facial expressions[J].Emotion, 2014, 14(3):469-77<\/span><\/p>\n

[9] Calcagnoli, F., et al.,Antiaggressive activity of central oxytocin in male rats[J]. Psychopharmacology(Heidelberg, Ger.), 2013. 229(4): 639-651<\/span><\/p>\n

[10]Peltola Mikko, J., et al., Motherhood and oxytocin receptor genetic variationare associated with selective changes in electrocortical responses to infantfacial expressions[J]. Emotion, 2014,14(3):469-77<\/span><\/p>\n

[11]Calcagnoli,F.,et al.Antiaggressive activity of central oxytocinin male rats. Psychopharmacology (Heidelberg, Ger.), 2013. 229(4):639-651.<\/span><\/p>\n

[12]Gurrieri, F. and G. Neri, Defective oxytocinfunction: a clue to understanding the cause of autism? BMC Med., 2009. 7: No ppgiven<\/span><\/p>\n

[13]Poulin, M.J. and E.A.Holman, Helping hands,healthy body? Oxytocin receptor gene and prosocial behavior interact to bufferthe association between stress and physical health. Horm. Behav., 2013. 63(3):510-517<\/span><\/p>\n

[14] Sasayama, D., et al., Negative correlation between cerebrospinal fluidoxytocin levels and negative symptoms of male patients with schizophrenia. SchizophrRes, 2012. 139(1-3): 201-6<\/span><\/p>\n

[15] Meddle SL.Dynamic changes in oxytocinreceptor expression and activation at parturition in the rat brain[J].Endocrinology.2007,148(10):5095-5104<\/span><\/p>\n

[16] Matthews SG.Hypothalamic Oxytocin in thedeveloping ovine fetus interaction with pituitary adrenocorticalfunction[J].Brain Res,1999,820(6):92-100<\/span><\/p>\n

[17] Nakashima T,Noguchi T,Furukawa T,etal.Brainoxytocin augments stress induced long lasting plasma adrenocorticotropichormone elevation in rat[J].Neurosci Lett, 2002, 321(3): 161-164.<\/span><\/p>\n

[18] Petersson M.Oxytocin decreases plasma levels of thyriod stimulatinghormone and thyriod hormones in rats[J].Regul Pept,2002,108(3):83-87<\/span><\/p>\n

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\u2299 <\/span>\u540c\u5199\u610f\u57f9\u8bad\uff1a<\/span><\/strong><\/p>\n

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\u59cb\u53d1\u4e8e\u5fae\u4fe1\u516c\u4f17\u53f7\uff1a \u836f\u4e8b\u7eb5\u6a2a <\/p>\n<\/blockquote>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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