{"id":77921,"date":"2019-01-19T00:00:50","date_gmt":"2019-02-01T06:11:20","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/77921\/"},"modified":"2019-02-01T14:11:20","modified_gmt":"2019-02-01T06:11:20","slug":"d305024e3c","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/77921\/","title":{"rendered":"\u9996\u4e2a\u7528\u4e8e\u665a\u671f\u80be\u7ec6\u80de\u764c\u521d\u6cbb\u60a3\u8005\u7684I-O\/I-O\u8054\u5408\u6cbb\u7597\u65b9\u6848\u5728\u6b27\u6d32\u83b7\u6279"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"box-sizing: border-box;padding-bottom: 28px;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\"><em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u9996\u4e2a\u7528\u4e8e\u665a\u671f\u80be\u7ec6\u80de\u764c\u521d\u6cbb\u60a3\u8005\u7684<\/em><em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">I-O\/I-O<\/em><em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u8054\u5408\u6cbb\u7597\u65b9\u6848\u5728\u6b27\u6d32\u83b7\u6279<br style=\"box-sizing: border-box;\"  \/><\/em><em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u83b7\u6279\u57fa\u4e8e<\/em><em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">CheckMate-214 III<\/em><em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u671f\u4e34\u5e8a\u7814\u7a76\u7ed3\u679c<\/em><\/p>\n<p style=\"box-sizing: border-box;padding-bottom: 28px;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u7f8e\u56fd\u65b0\u6cfd\u897f\u5dde\u666e\u6797\u65af\u987f2019\u5e741\u670815\u65e5\u7535 \/\/ &#8212; \u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\uff08NYSE:BMY\uff09<span style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">1\u670814\u65e5<\/span>\u5ba3\u5e03\uff0c<em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297\uff08\u6b27\u72c4\u6c83\uff09<\/em>3 mg\/kg\u8054\u5408<em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u4f0a\u5339\u6728\u5355\u6297<\/em>1 mg\/kg \uff08\u201c\u4f4e\u5242\u91cf\u201d\uff09\u65b9\u6848\u5df2\u83b7\u6b27\u76df\u59d4\u5458\u4f1a\u6279\u51c6\uff0c\u7528\u4e8e\u4e2d\u9ad8\u5371\u665a\u671f\u80be\u7ec6\u80de\u764c\uff08RCC\uff09\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002\u8fd9\u662f\u9996\u4e2a\u83b7\u6b27\u76df\u6279\u51c6\u9488\u5bf9\u8be5\u7c7b\u60a3\u8005\u7684\u514d\u75ab\u80bf\u7624\uff08I-O\uff09\u8054\u5408\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n<p><br  \/><\/p>\n<p style=\"box-sizing: border-box;padding-bottom: 28px;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u201c\u76ee\u524d\uff0c\u4e0d\u8db350%\u8f6c\u79fb\u6027\u80be\u7ec6\u80de\u764c\u60a3\u8005\u7684\u751f\u5b58\u671f\u80fd\u591f\u8d85\u8fc7\u4e24\u5e74\uff0c\u4e14\u51e0\u4e4e\u672a\u89c1\u5b8c\u5168\u7f13\u89e3\u6848\u4f8b\uff0c\u8fd9\u4e9b\u73b0\u72b6\u51f8\u663e\u4e86\u60a3\u8005\u5bf9\u80be\u7ec6\u80de\u764c\u65b0\u7597\u6cd5\u7684\u8feb\u5207\u9700\u6c42\u3002\u201d\u6cd5\u56fd\u53e4\u65af\u5854\u592b\u00b7\u9c81\u897f\u764c\u75c7\u7814\u7a76\u6240\uff08Gustave Roussy\uff09\u6ccc\u5c3f\u751f\u6b96\u80bf\u7624\u59d4\u5458\u4f1a\u524d\u4e3b\u5e2d\u3001\u533b\u5b66\u535a\u58ebBernard Escudier\u8868\u793a\uff1a\u201c\u6b64\u6b21\u83b7\u6279\u4e3a\u6b27\u76df\u60a3\u8005\u63d0\u4f9b\u4e86\u65b0\u7684\u4e00\u7ebf\u6cbb\u7597\u9009\u62e9\u3002\u76f8\u8f83\u4e8e\u8212\u5c3c\u66ff\u5c3c\uff0c\u8fd9\u4e00\u514d\u75ab\u80bf\u7624\uff08I-O\uff09\u8054\u5408\u6cbb\u7597\u65b9\u6848\u7684\u5b8c\u5168\u7f13\u89e3\u7387\u63a5\u8fd110%\uff0c\u603b\u4f53\u751f\u5b58\u7387\uff08OS\uff09\u83b7\u5f97\u663e\u8457\u63d0\u9ad8\uff0c\u4e14\u6709\u66f4\u4f4e\u76843\u7ea7\u548c4\u7ea7\u4e0d\u826f\u53cd\u5e94\u3002\u201d<\/p>\n<p style=\"box-sizing: border-box;padding-bottom: 28px;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u6b64\u6b21\u83b7\u6279\u662f\u57fa\u4e8eCheckMate-214 III\u671f\u4e34\u5e8a\u7814\u7a76\u7684\u7ed3\u679c\u3002\u8be5\u8bd5\u9a8c\u5728\u6309\u8ba1\u5212\u8fdb\u884c\u7684\u4e2d\u671f\u5206\u6790\u540e\u63d0\u524d\u7ec8\u6b62\u3002\u5206\u6790\u663e\u793a\uff0c<em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297<\/em>\u548c\u4f4e\u5242\u91cf<em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u4f0a\u5339\u6728\u5355\u6297<\/em>\u8054\u5408\u6cbb\u7597\u53ef\u663e\u8457\u63d0\u9ad8OS\u3002\u4e0e\u76ee\u524d\u7684\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u8212\u5c3c\u66ff\u5c3c\u76f8\u6bd4\uff0c\u4e2d\u9ad8\u5371\u60a3\u8005\u7684\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e8637%\uff08HR 0.63; 99.8% CI: 0.44 to 0.89; p&lt;0.0001\uff09\u3002\u65e0\u8bbaPD-L1\u8868\u8fbe\u6c34\u5e73\u5982\u4f55\uff0c\u5747\u89c2\u5bdf\u5230OS\u83b7\u76ca\u3002\u622a\u6b62\u5230\u76ee\u524d\uff0c\u63a5\u53d7<em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297<\/em>\u8054\u5408\u4f4e\u5242\u91cf<em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u4f0a\u5339\u6728\u5355\u6297<\/em>\u6cbb\u7597\u60a3\u8005\u7ec4\u7684\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\u5c1a\u672a\u8fbe\u5230\uff0895% CI: 28.2\u4e2a\u6708\u5230\u4e0d\u53ef\u8bc4\u4f30[NE]\uff09\uff0c\u800c\u8212\u5c3c\u66ff\u5c3c\u6cbb\u7597\u60a3\u8005\u7ec4\u7684\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\u4e3a25.9\u4e2a\u6708\u3002<\/p>\n<p style=\"box-sizing: border-box;padding-bottom: 28px;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u4e0e\u6b64\u540c\u65f6\uff0c<em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297<\/em>\u8054\u5408\u4f4e\u5242\u91cf<em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u4f0a\u5339\u6728\u5355\u6297<\/em>\u65b9\u6848\u8fd8\u663e\u793a\u51fa\u4e86\u66f4\u9ad8\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff0c\u8fbe\u523041.6%\uff0895% CI: 36.9 to 46.5; p&lt;0.0001; n=177\/425\uff09\uff0c\u8212\u5c3c\u66ff\u5c3c\u4e3a26.5%\uff0895% CI: 22.4 to 31.0; n=112\/422\uff09\u3002<em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297<\/em>\u548c\u4f4e\u5242\u91cf<em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u4f0a\u5339\u6728\u5355\u6297<\/em>\u8054\u5408\u6cbb\u7597\u7ec4\u7684\u5b8c\u5168\u7f13\u89e3\u7387\u4e3a9.4%\uff0c\u8212\u5c3c\u66ff\u5c3c\u7ec4\u4e3a1.2%\u3002\u5728\u5e94\u7b54\u60a3\u8005\u4e2d\uff0c\u63a5\u53d7<em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297<\/em>\u548c\u4f4e\u5242\u91cf<em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u4f0a\u5339\u6728\u5355\u6297<\/em>\u8054\u5408\u6cbb\u7597\u60a3\u8005\u7684\u4e2d\u4f4d\u7f13\u89e3\u65f6\u95f4\u5c1a\u672a\u8fbe\u5230\uff0895% CI: 21.8\u4e2a\u6708\u5230NE\uff09\uff0c\u8212\u5c3c\u66ff\u5c3c\u7ec4\u4e3a18.2\u4e2a\u6708\uff0895% CI: 14.8\u4e2a\u6708\u5230NE\uff09\u3002\u6b64\u5916\uff0c<em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297<\/em>\u548c\u4f4e\u5242\u91cf<em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u4f0a\u5339\u6728\u5355\u6297<\/em>\u8054\u5408\u6cbb\u7597\u76f8\u6bd4\u4e8e\u8212\u5c3c\u66ff\u5c3c\u6cbb\u7597\uff0c\u6240\u53d1\u751f\u76843\u62164\u7ea7\u4e0d\u826f\u4e8b\u4ef6\u66f4\u5c11\uff0865% vs 76%\uff09\u3002<\/p>\n<p style=\"box-sizing: border-box;padding-bottom: 28px;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u201c\u57fa\u4e8eCheckMate-214\u4e34\u5e8a\u7814\u7a76\u7684\u663e\u8457\u751f\u5b58\u83b7\u76ca\u6570\u636e\uff0c\u6b27\u76df\u59d4\u5458\u4f1a\u6279\u51c6\u4e86<em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297<\/em>\u8054\u5408\u4f4e\u5242\u91cf<em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u4f0a\u5339\u6728\u5355\u6297<\/em>\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u8fd9\u4ee4\u6211\u4eec\u975e\u5e38\u6b23\u559c\u3002\u201d\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u516c\u53f8\u9996\u5e2d\u5546\u4e1a\u5b98Chris Boerner\u8868\u793a\uff1a\u201c\u8fd9\u4e00\u83b7\u6279\u5c06\u5e2e\u52a9\u6211\u4eec\u8fdb\u4e00\u6b65\u5b9e\u73b0\u9769\u65b0\u764c\u75c7\u6cbb\u7597\u65b9\u5f0f\u3001\u63d0\u5347\u60a3\u8005\u751f\u6d3b\u8d28\u91cf\u5e76\u5b9e\u73b0\u957f\u671f\u751f\u5b58\u83b7\u76ca\u7684\u76ee\u6807\u3002\u201d<\/p>\n<p style=\"box-sizing: border-box;padding-bottom: 28px;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\"><span style=\"box-sizing: border-box;font-weight: bolder;\"><span style=\"box-sizing: border-box;text-decoration:underline;\">\u5173\u4e8eCheckMate-214<\/span><\/span><\/p>\n<p style=\"box-sizing: border-box;padding-bottom: 28px;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">CheckMate-214\u662f\u4e00\u9879\u968f\u673a\u3001\u5f00\u653e\u6807\u7b7e\u7684III\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8bc4\u4f30<em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297<\/em>&nbsp;3 mg\/kg \u8054\u5408<em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u4f0a\u5339\u6728\u5355\u6297<\/em>1 mg\/kg\u5bf9\u6bd4\u8212\u5c3c\u66ff\u5c3c\u7528\u4e8e\u521d\u6cbb\u665a\u671f\u80be\u7ec6\u80de\u764c\uff08RCC\uff09\u60a3\u8005\u7684\u6cbb\u7597\u60c5\u51b5\u3002\u5728\u4e2d\u9ad8\u5371\u7814\u7a76\u4eba\u7fa4\u4e2d\uff0c425\u4f8b\u60a3\u8005\u63a5\u53d7<em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297<\/em>3 mg\/kg\u8054\u5408<em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u4f0a\u5339\u6728\u5355\u6297<\/em>1 mg\/kg\u6cbb\u7597\uff0c\u6bcf3\u54681\u6b21\uff0c\u8fde\u7eed\u7528\u836f4\u4e2a\u5468\u671f\u540e\uff0c\u5e8f\u8d2f&nbsp;<em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297<\/em>&nbsp;3 mg\/kg\uff0c\u6bcf2\u54681\u6b21\u3002422\u4f8b\u60a3\u8005\u63a5\u53d7\u8212\u5c3c\u66ff\u5c3c50mg\u6cbb\u7597\uff0c\u6bcf\u65e51\u6b21\uff0c\u6301\u7eed4\u5468\uff0c\u4f11\u606f2\u5468\u540e\u518d\u7ee7\u7eed\u4e0b\u4e00\u5468\u671f\u3002<em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297<\/em>\u548c\u4f4e\u5242\u91cf<em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u4f0a\u5339\u6728\u5355\u6297<\/em>\u8054\u5408\u7528\u836f\u7684\u63a8\u8350\u5242\u91cf\u4e3a\uff1a<em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297<\/em><em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">&nbsp;<\/em>3 mg\/kg\uff0c\u968f\u540e\u662f<em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u4f0a\u5339\u6728\u5355\u6297<\/em><em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">&nbsp;<\/em>1 mg\/kg\uff0c\u5728\u540c\u4e00\u5929\u5206\u522b\u9759\u8109\u6ce8\u5c04\uff0c\u6bcf\u6b21\u6ce8\u5c04\u65f6\u95f4\u572830\u5206\u949f\u4ee5\u4e0a\uff0c\u6bcf3\u54681\u6b21\uff0c\u51714\u6b21\u3002\u5728\u5b8c\u62104\u6b21\u8054\u5408\u7528\u836f\u540e\uff0c\u5e94\u6bcf2\u5468\u9759\u8109\u7ed9\u4e88<em style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u7eb3\u6b66\u5229\u5c24\u5355\u6297<\/em>&nbsp;240mg\uff0c\u6bcf\u6b2130\u5206\u949f\u4ee5\u4e0a\uff0c\u6216\u6bcf4\u5468\u9759\u8109\u7ed9\u836f480mg\uff0c\u6bcf\u6b2160\u5206\u949f\u4ee5\u4e0a\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<\/p>\n<p style=\"box-sizing: border-box;padding-bottom: 28px;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u8be5\u8bd5\u9a8c\u7684\u590d\u5408\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u4e3a\u4e2d\u9ad8\u5371\u60a3\u8005\u7684\u603b\u751f\u5b58\u671f\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08\u5b8c\u5168\u7f13\u89e3+\u90e8\u5206\u7f13\u89e3\uff09\u548c\u72ec\u7acb\u5f71\u50cf\u68c0\u67e5\u59d4\u5458\u4f1a\uff08IRRC\uff09\u786e\u5b9a\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u3002\u8be5\u8bd5\u9a8c\u672a\u8003\u8651\u7814\u7a76\u60a3\u8005\u7684PD-L1\u72b6\u6001\u3002<\/p>\n<p style=\"box-sizing: border-box;padding-bottom: 28px;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\"><span style=\"box-sizing: border-box;font-weight: bolder;\"><span style=\"box-sizing: border-box;text-decoration:underline;\">\u5173\u4e8e\u80be\u7ec6\u80de\u764c<\/span><\/span><\/p>\n<p style=\"box-sizing: border-box;padding-bottom: 28px;border-width: 0px;border-style: initial;border-color: initial;list-style: 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