{"id":78238,"date":"2018-12-12T00:00:50","date_gmt":"2019-02-01T06:14:55","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/78238\/"},"modified":"2019-02-01T14:14:59","modified_gmt":"2019-02-01T06:14:59","slug":"c4ad2b357b","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/78238\/","title":{"rendered":"\u3010\u8ffd\u8e2a\u3011\u8d1d\u8fbe\u836f\u4e1aFGFR\u6291\u5236\u5242\u548c\u559c\u9e4a\u533b\u836f\u65b0\u836f\u63d0\u4ea4\u4e34\u5e8a\u7533\u8bf7"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/9-1549001696.png\" alt=\"\u3010\u8ffd\u8e2a\u3011\u8d1d\u8fbe\u836f\u4e1aFGFR\u6291\u5236\u5242\u548c\u559c\u9e4a\u533b\u836f\u65b0\u836f\u63d0\u4ea4\u4e34\u5e8a\u7533\u8bf7\" title=\"\u3010\u8ffd\u8e2a\u3011\u8d1d\u8fbe\u836f\u4e1aFGFR\u6291\u5236\u5242\u548c\u559c\u9e4a\u533b\u836f\u65b0\u836f\u63d0\u4ea4\u4e34\u5e8a\u7533\u8bf7\"><\/p>\n<p style=\"text-align: justify;\">12\u67086\u65e5\uff0c\u8d1d\u8fbe\u836f\u4e1a\u80a1\u4efd\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0\u201c\u8d1d\u8fbe\u836f\u4e1a\u201d\u6216\u201c\u516c\u53f8\u201d\uff09\u6536\u5230\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u7b7e\u53d1\u7684\u300a\u53d7\u7406\u901a\u77e5\u4e66\u300b\uff08\u53d7\u7406\u53f7\uff1aCXHL1800192\u56fd\u3001CXHL1800205\u56fd\u3001CXHL1800206\u56fd\uff09\uff0c\u516c\u53f8\u7533\u62a5\u7684BPI-17509\u548cBPI-17509\u7247\u7684\u836f\u54c1\u4e34\u5e8a\u8bd5\u9a8c\uff08\u4ee5\u4e0b\u7b80\u79f0\u201c\u8be5\u4e34\u5e8a\u8bd5\u9a8c\u201d\uff09\u7533\u8bf7\u5df2\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u53d7\u7406\uff0c\u73b0\u5c06\u5177\u4f53\u60c5\u51b5\u516c\u544a\u5982\u4e0b\uff1a<\/p>\n<p style=\"text-align: justify;\"><strong>\u4e00\u3001\u8be5\u4e34\u5e8a\u8bd5\u9a8c\u7684\u57fa\u672c\u60c5\u51b5<\/strong><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: rgb(0, 82, 255);\">1\u3001BPI-17509<\/span><\/p>\n<p style=\"text-align: justify;\">\u53d7\u7406\u53f7\uff1aCXHL1800192\u56fd<\/p>\n<p style=\"text-align: justify;\">\u7533\u8bf7\u4e8b\u9879\uff1a\u65b0\u836f\u7533\u8bf7\uff1b\u7279\u6b8a\u5ba1\u6279\u7a0b\u5e8f<\/p>\n<p style=\"text-align: justify;\">\u7533\u8bf7\u4eba\uff1a\u8d1d\u8fbe\u836f\u4e1a\u80a1\u4efd\u6709\u9650\u516c\u53f8<\/p>\n<p style=\"text-align: justify;\">\u7ed3\u8bba\uff1a\u6839\u636e\u300a\u4e2d\u534e\u4eba\u6c11\u5171\u548c\u56fd\u884c\u653f\u8bb8\u53ef\u6cd5\u300b\u7b2c\u4e09\u5341\u4e8c\u6761\u7684\u89c4\u5b9a\uff0c\u7ecf\u5ba1\u67e5\uff0c\u51b3\u5b9a\u4e88\u4ee5\u53d7\u7406\u3002<\/p>\n<p style=\"text-align: justify;\"><span style=\"color: rgb(0, 82, 255);\">2\u3001BPI-17509\u7247<\/span><\/p>\n<p style=\"text-align: justify;\">\u53d7\u7406\u53f7\uff1aCXHL1800205\u56fd\u3001CXHL1800206\u56fd<\/p>\n<p style=\"text-align: justify;\">\u7533\u8bf7\u4e8b\u9879\uff1a\u65b0\u836f\u7533\u8bf7\uff1b\u7279\u6b8a\u5ba1\u6279\u7a0b\u5e8f<\/p>\n<p style=\"text-align: justify;\">\u7533\u8bf7\u4eba\uff1a\u8d1d\u8fbe\u836f\u4e1a\u80a1\u4efd\u6709\u9650\u516c\u53f8<\/p>\n<p style=\"text-align: justify;\">\u7ed3\u8bba\uff1a\u6839\u636e\u300a\u4e2d\u534e\u4eba\u6c11\u5171\u548c\u56fd\u884c\u653f\u8bb8\u53ef\u6cd5\u300b\u7b2c\u4e09\u5341\u4e8c\u6761\u7684\u89c4\u5b9a\uff0c\u7ecf\u5ba1\u67e5\uff0c\u51b3\u5b9a\u4e88\u4ee5\u53d7\u7406\u3002<\/p>\n<p style=\"text-align: justify;\"><strong>\u4e8c\u3001\u8be5\u4e34\u5e8a\u8bd5\u9a8c\u7528\u836f\u7684\u7814\u7a76\u60c5\u51b5<\/strong><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: rgb(0, 82, 255);\">BPI-17509\u662f\u8d1d\u8fbe\u836f\u4e1a\u81ea\u4e3b\u7814\u53d1\u7684\u5168\u65b0\u5316\u5b66\u7ed3\u6784\u7684\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08FGFR1\/2\/3\uff09\u5c0f\u5206\u5b50\u53e3\u670d\u6291\u5236\u5242\uff0c\u62df\u7528\u4e8e\u53d1\u751fFGFR\u57fa\u56e0\u878d\u5408\u7a81\u53d8\u6216\u6269\u589e\u7684\u5404\u7c7b\u80bf\u7624\u6cbb\u7597\u3002<\/span>FGFR\u5c5e\u4e8e\u916a\u6c28\u9178\u53d7\u4f53\u6fc0\u9176\u5bb6\u65cf\uff0c\u5305\u62ec\u56db\u79cd\u53d7\u4f53\u4e9a\u578b\uff08FGFR-1,2,3\u548c4\uff09\u4ee5\u53ca\u4e00\u4e9b\u5f02\u6784\u5206\u5b50\uff0c\u5728\u80bf\u7624\u589e\u6b96\u3001\u8840\u7ba1\u751f\u6210\u3001\u8fc1\u79fb\u548c\u5b58\u6d3b\u4e2d\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u5931\u63a7\u7684FGFRs\u4fe1\u53f7\u4e0e\u591a\u79cd\u6076\u6027\u80bf\u7624\u7684\u53d1\u751f\u53d1\u5c55\u5bc6\u5207\u76f8\u5173\uff0c\u4e00\u4e9b\u764c\u75c7\u4e2dFGFRs\u901a\u8fc7\u57fa\u56e0\u6269\u589e\u3001\u67d3\u8272\u4f53\u6613\u4f4d\u548c\u7a81\u53d8\u51e0\u79cd\u673a\u5236\u8fc7\u5ea6\u6fc0\u6d3b, \u4f7f\u5f97\u764c\u7ec6\u80de\u83b7\u5f97\u8fc7\u5ea6\u589e\u6b96\u3001\u9003\u907f\u51cb\u4ea1\u3001\u5bb9\u6613\u8fc1\u79fb\u7b49\u81f4\u764c\u7279\u6027\u3002BPI-17509\u901a\u8fc7\u7279\u5f02\u6027\u6291\u5236FGFR1\/2\/3\u7684\u6d3b\u6027\u963b\u6ede\u76f8\u5173\u4fe1\u53f7\u4f20\u5bfc\u7684\u9014\u5f84\uff0c\u8fdb\u800c\u5f71\u54cd\u751f\u7269\u4f53\u5185\u7ec6\u80de\u589e\u6b96\u3001\u51cb\u4ea1\u3001\u8fc1\u79fb\u3001\u65b0\u751f\u8840\u7ba1\u751f\u6210\u7b49\u591a\u4e2a\u751f\u7406\u8fc7\u7a0b\uff0c\u6700\u7ec8\u8fbe\u5230\u6291\u5236\u80bf\u7624\u751f\u957f\u7684\u76ee\u6807\u3002<\/p>\n<p style=\"text-align: justify;\">\u622a\u81f3\u672c\u516c\u544a\u62ab\u9732\u65e5\uff0c\u56fd\u5185\u5916\u5c1a\u65e0\u540c\u9776\u70b9\u3001\u7597\u6548\u597d\u7684\u6cbb\u7597\u836f\u7269\u4e0a\u5e02\uff0c\u6839\u636e\u56fd\u5bb6\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u603b\u5c40\u53d1\u5e03\u7684\u5316\u5b66\u836f\u54c1\u6ce8\u518c\u5206\u7c7b\u6539\u9769\u5de5\u4f5c\u65b9\u6848\u7684\u516c\u544a\uff082016\u5e74\u7b2c51\u53f7\uff09\uff0cBPI-17509\u5c5e\u4e8e\u201c\u5883\u5185\u5916\u5747\u672a\u4e0a\u5e02\u7684\u521b\u65b0\u836f\u201d\uff0c\u5176\u6ce8\u518c\u5206\u7c7b\u4e3a\u5316\u5b66\u836f\u54c11\u7c7b\u3002<\/p>\n<p style=\"text-align: justify;\"><strong><span style=\"color: rgb(0, 82, 255);\">\u5e7f\u5dde\u559c\u9e4a\u533b\u836f\u6709\u9650\u516c\u53f8<\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/1-1549001696.png\" alt=\"\u3010\u8ffd\u8e2a\u3011\u8d1d\u8fbe\u836f\u4e1aFGFR\u6291\u5236\u5242\u548c\u559c\u9e4a\u533b\u836f\u65b0\u836f\u63d0\u4ea4\u4e34\u5e8a\u7533\u8bf7\" title=\"\u3010\u8ffd\u8e2a\u3011\u8d1d\u8fbe\u836f\u4e1aFGFR\u6291\u5236\u5242\u548c\u559c\u9e4a\u533b\u836f\u65b0\u836f\u63d0\u4ea4\u4e34\u5e8a\u7533\u8bf7\"><\/p>\n<p style=\"text-align: justify;\"><strong><span style=\"color: rgb(0, 82, 255);\"><\/span><\/strong><br  \/><\/p>\n<p style=\"text-align: justify;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/10-1549001696.png\" alt=\"\u3010\u8ffd\u8e2a\u3011\u8d1d\u8fbe\u836f\u4e1aFGFR\u6291\u5236\u5242\u548c\u559c\u9e4a\u533b\u836f\u65b0\u836f\u63d0\u4ea4\u4e34\u5e8a\u7533\u8bf7\" title=\"\u3010\u8ffd\u8e2a\u3011\u8d1d\u8fbe\u836f\u4e1aFGFR\u6291\u5236\u5242\u548c\u559c\u9e4a\u533b\u836f\u65b0\u836f\u63d0\u4ea4\u4e34\u5e8a\u7533\u8bf7\"><span style=\"color: rgb(0, 82, 255);\"><strong>\u785d\u916e\u55ea<\/strong><\/span><br  \/><\/p>\n<p style=\"text-align: justify;\"><img class=\"\"      style=\"text-align: center;white-space: normal;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/10-1549001697.jpg\" alt=\"\u3010\u8ffd\u8e2a\u3011\u8d1d\u8fbe\u836f\u4e1aFGFR\u6291\u5236\u5242\u548c\u559c\u9e4a\u533b\u836f\u65b0\u836f\u63d0\u4ea4\u4e34\u5e8a\u7533\u8bf7\" title=\"\u3010\u8ffd\u8e2a\u3011\u8d1d\u8fbe\u836f\u4e1aFGFR\u6291\u5236\u5242\u548c\u559c\u9e4a\u533b\u836f\u65b0\u836f\u63d0\u4ea4\u4e34\u5e8a\u7533\u8bf7\">\u5e7f\u5dde\u559c\u9e4a\u533b\u836f\u6709\u9650\u516c\u53f8\u662f\u4e00\u5bb6\u521b\u65b0\u836f\u7269\u7814\u7a76\u4e0e\u5f00\u53d1\u516c\u53f8\uff0c\u4e13\u6ce8\u4e8e\u5f00\u53d1\u5177\u6709\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684&nbsp;First in Class&nbsp;\u548c&nbsp;First in World&nbsp;\u7684&nbsp;\u201c\u5168\u7403\u65b0\u201d&nbsp;\u836f\u7269\u3002\u57fa\u4e8e\u56fd\u5bb6\u5b9e\u73b0\u4e2d\u836f\u73b0\u4ee3\u5316\u548c\u5168\u7403\u521b\u65b0\u836f\u7269\u53d1\u5c55\u7684\u8d8b\u52bf\uff0c\u559c\u9e4a\u533b\u836f\u5efa\u7acb\u4e86\u72ec\u7279\u7684\u836f\u7269\u7814\u53d1\u5e73\u53f0\uff0c\u5bf9\u4f20\u7edf\u4e2d\u836f\u4e2d\u7684\u6d3b\u6027\u5929\u7136\u4ea7\u7269\u5355\u4f53\u6216\u76ee\u524d\u4e34\u5e8a\u6b63\u5728\u4f7f\u7528\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\u8fdb\u884c\u7ed3\u6784\u4fee\u9970\u6216\u6539\u9020\uff0c\u4ee5\u671f\u5927\u5e45\u589e\u52a0\u6d3b\u6027\u548c\u529f\u80fd\u3002<\/p>\n<p style=\"text-align: justify;\">\u516c\u53f8\u6b63\u5728\u7814\u7a76\u5f00\u53d1\u7684\u521b\u65b0\u836f\u7269\u6709\u5341\u51e0\u4e2a\uff0c\u5176\u4e2d\u785d\u916e\u55ea(TBN)\u6cbb\u7597\u7f3a\u8840\u6027\u8111\u4e2d\u98ce\u9879\u76ee\u5df2\u83b7\u5f97\u56fd\u5bb6\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40&nbsp;(CFDA)&nbsp;\u7684\u65b0\u836f\u4e34\u5e8a\u7814\u7a76\u6279\u4ef6\uff0c\u6b63\u5728\u8fdb\u884c&nbsp;I&nbsp;\u671f\u4e34\u5e8a\u7814\u7a76\u3002\u9884\u8ba1\u672a\u67653\u5e74\uff0c\u559c\u9e4a\u5c06\u83b7\u5f97\u56fd\u5185\u4e34\u5e8a\u7814\u7a76\u6279\u4ef6&nbsp;4-6&nbsp;\u9879\uff0c\u6b27\u7f8e\u56fd\u5bb6\u4e34\u5e8a\u7814\u7a76\u6279\u4ef6&nbsp;1-2&nbsp;\u9879\u3002<\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/8-1549001697.jpg\" alt=\"\u3010\u8ffd\u8e2a\u3011\u8d1d\u8fbe\u836f\u4e1aFGFR\u6291\u5236\u5242\u548c\u559c\u9e4a\u533b\u836f\u65b0\u836f\u63d0\u4ea4\u4e34\u5e8a\u7533\u8bf7\" title=\"\u3010\u8ffd\u8e2a\u3011\u8d1d\u8fbe\u836f\u4e1aFGFR\u6291\u5236\u5242\u548c\u559c\u9e4a\u533b\u836f\u65b0\u836f\u63d0\u4ea4\u4e34\u5e8a\u7533\u8bf7\"><\/p>\n<p style=\"text-align: justify;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/0-1549001697.jpg\" alt=\"\u3010\u8ffd\u8e2a\u3011\u8d1d\u8fbe\u836f\u4e1aFGFR\u6291\u5236\u5242\u548c\u559c\u9e4a\u533b\u836f\u65b0\u836f\u63d0\u4ea4\u4e34\u5e8a\u7533\u8bf7\" title=\"\u3010\u8ffd\u8e2a\u3011\u8d1d\u8fbe\u836f\u4e1aFGFR\u6291\u5236\u5242\u548c\u559c\u9e4a\u533b\u836f\u65b0\u836f\u63d0\u4ea4\u4e34\u5e8a\u7533\u8bf7\"><strong style=\"color: rgb(0, 82, 255);\">\u7f8e\u91d1\u521a\u785d\u9178\u916f<\/strong><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/3-1549001698.jpg\" alt=\"\u3010\u8ffd\u8e2a\u3011\u8d1d\u8fbe\u836f\u4e1aFGFR\u6291\u5236\u5242\u548c\u559c\u9e4a\u533b\u836f\u65b0\u836f\u63d0\u4ea4\u4e34\u5e8a\u7533\u8bf7\" title=\"\u3010\u8ffd\u8e2a\u3011\u8d1d\u8fbe\u836f\u4e1aFGFR\u6291\u5236\u5242\u548c\u559c\u9e4a\u533b\u836f\u65b0\u836f\u63d0\u4ea4\u4e34\u5e8a\u7533\u8bf7\"><\/p>\n<p style=\"text-align: justify;\"><strong style=\"color: rgb(0, 82, 255);\">T-006<\/strong><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/1-1549001698.jpg\" alt=\"\u3010\u8ffd\u8e2a\u3011\u8d1d\u8fbe\u836f\u4e1aFGFR\u6291\u5236\u5242\u548c\u559c\u9e4a\u533b\u836f\u65b0\u836f\u63d0\u4ea4\u4e34\u5e8a\u7533\u8bf7\" title=\"\u3010\u8ffd\u8e2a\u3011\u8d1d\u8fbe\u836f\u4e1aFGFR\u6291\u5236\u5242\u548c\u559c\u9e4a\u533b\u836f\u65b0\u836f\u63d0\u4ea4\u4e34\u5e8a\u7533\u8bf7\"><\/p>\n<p style=\"text-align: justify;\"><strong><span style=\"color: rgb(0, 82, 255);\">AL-1<\/span><\/strong><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"      style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/5-1549001699.jpg\" alt=\"\u3010\u8ffd\u8e2a\u3011\u8d1d\u8fbe\u836f\u4e1aFGFR\u6291\u5236\u5242\u548c\u559c\u9e4a\u533b\u836f\u65b0\u836f\u63d0\u4ea4\u4e34\u5e8a\u7533\u8bf7\" title=\"\u3010\u8ffd\u8e2a\u3011\u8d1d\u8fbe\u836f\u4e1aFGFR\u6291\u5236\u5242\u548c\u559c\u9e4a\u533b\u836f\u65b0\u836f\u63d0\u4ea4\u4e34\u5e8a\u7533\u8bf7\"><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: rgb(0, 82, 255);\"><strong>\u4e39\u53c2\u7d20\u884d\u751f\u7269<\/strong><\/span><br  \/><\/p>\n<p style=\"text-align: center;\">\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>12\u67086\u65e5\uff0c\u8d1d\u8fbe\u836f\u4e1a\u80a1\u4efd\u6709\u9650\u516c\u53f8\uff08\u4ee5\u4e0b\u7b80\u79f0\u201c\u8d1d\u8fbe\u836f\u4e1a\u201d\u6216\u201c\u516c\u53f8\u201d\uff09\u6536\u5230\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u7b7e\u53d1\u7684\u300a\u53d7\u7406\u901a\u77e5\u4e66\u300b\uff08 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":78239,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/78238"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=78238"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/78238\/revisions"}],"predecessor-version":[{"id":78249,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/78238\/revisions\/78249"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/78239"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=78238"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=78238"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=78238"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}