{"id":78283,"date":"2019-01-25T00:00:50","date_gmt":"2019-02-01T06:15:28","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/78283\/"},"modified":"2019-02-01T14:15:30","modified_gmt":"2019-02-01T06:15:30","slug":"f848240954","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/78283\/","title":{"rendered":"Loxo Oncology\uff1a\u81f4\u529b\u80bf\u7624\u5c0f\u5206\u5b50\u7cbe\u51c6\u7597\u6cd5\u7684\u6210\u529f\u5178\u8303"},"content":{"rendered":"
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Loxo Oncology\u516c\u53f8\u521b\u7acb\u4e8e2013\u5e74\uff0c\u7ecf\u8fc7\u77ed\u77ed5\u5e74\u591a\u65f6\u95f4\u7684\u53d1\u5c55\uff0c\u73b0\u4eca\u5df2\u6210\u4e3a\u5168\u7403\u751f\u7269\u5236\u836f\u884c\u4e1a\u4ece\u4e8b\u5c0f\u5206\u5b50\u80bf\u7624\u7cbe\u51c6\u7597\u6cd5\u7684\u65b0\u9510\u516c\u53f8\u30022018\u5e74\u516c\u53f8\u8fce\u6765\u9996\u4e2a\u4e0a\u5e02\u836f\u7269\uff0c\u4e24\u4e2a\u591a\u6708\u524dFDA\u6279\u51c6\u5176\u9776\u5411\u6297\u764c\u836fVitrakvi\uff08larotrectinib\uff09\uff0c\u7528\u4e8e\u643a\u5e26NTRK\u57fa\u56e0\u878d\u5408\u7684\u665a\u671f\u5b9e\u4f53\u7624\u513f\u7ae5\u548c\u6210\u4eba\u60a3\u8005\u30022019\u5e741\u6708\uff0cLoxo Oncology\u516c\u53f8\u88ab\u5236\u836f\u5de8\u5934\u793c\u6765\u516c\u53f8\u4ee580\u4ebf\u7f8e\u5143\u6536\u8d2d\uff0c\u5176\u91cd\u78c5\u201c\u4e0d\u9650\u764c\u79cd\u201d\u9776\u5411\u836fVitrakvi\uff08larotrectinib\uff09\u76ee\u524d\u5df2\u7ecf\u5728\u4e2d\u56fd\u7533\u62a5\u4e34\u5e8a\u8bd5\u9a8c\uff08IND\uff09\uff0c\u5e76\u83b7\u5f97\u53d7\u7406\u3002\u672c\u6587\u6839\u636e\u516c\u53f8\u5b98\u7f51\u3001\u79d1\u777f\u552f\u5b89Integrity\u6570\u636e\u5e93\u7b49\u5bf9Loxo Oncology\u516c\u53f8\u7684\u4e0a\u5e02\u836f\u7269\u548c\u5728\u7814\u54c1\u79cd\u8fdb\u884c\u8be6\u7ec6\u4ecb\u7ecd\u3002<\/span><\/p>\n

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2019\u5e741\u67087\u65e5\uff0c\u7f8e\u56fd\u5236\u836f\u516c\u53f8\u793c\u6765\uff08Eli Lilly&Co\uff09\u548cLoxo Oncology\u8054\u5408\u5ba3\u5e03\uff0c\u53cc\u65b9\u8fbe\u6210\u5e76\u8d2d\u534f\u8bae\u3002\u793c\u6765\u5c06\u4ee5\u7ea680\u4ebf\u7f8e\u5143\u6536\u8d2d\u5df2\u5728\u7eb3\u65af\u8fbe\u514b\u4e0a\u5e02\u7684\u751f\u7269\u533b\u836f\u516c\u53f8Loxo Oncology\uff1b\u793c\u6765\u516c\u53f8\u5c06\u4ee5\u6bcf\u80a1235\u7f8e\u5143\u3001\u6ea2\u4ef768%\u3001\u603b\u503c80\u4ebf\u7f8e\u5143\u6536\u8d2d\u6210\u7acb\u8fd8\u4e0d\u52306\u5e74\u7684\u751f\u7269\u5236\u836f\u516c\u53f8Loxo Oncology\uff0c\u53cc\u65b9\u6b64\u9879\u4ea4\u6613\u8ba1\u5212\u57282019\u5e74Q1\u5b8c\u6210\u3002\u6d88\u606f\u4e00\u51faLoxo\u80a1\u7968\u5e94\u52bf\u66b4\u6da866%\u3002\u672c\u6b21\u6536\u8d2d\u793c\u6765\u5c06\u83b7\u5f97\u5df2\u7ecf\u4e0a\u5e02\u7684\u6cdb\u7ec4\u7ec7\u6297\u764c\u836f\u7269NTRK\u6291\u5236\u5242Vitrakvi\u7684\u4e00\u534a\u6743\u76ca\u3001\u53e6\u4e00\u4e2a\u6cdb\u7ec4\u7ec7\u836f\u7269RET\u6291\u5236\u5242LOXO-292\u3001\u4e34\u5e8a\u2160\u671fBTK\u6291\u5236\u5242LOXO-305\u548c\u51e0\u4e2a\u4e34\u5e8a\u524d\u4ea7\u54c1\u3002<\/span>
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Loxo Oncology\u516c\u53f8\uff08Loxo Oncology, Inc.\uff09\u662f\u4e00\u5bb6\u4ece\u4e8b\u80bf\u7624\u53d1\u7684\u660e\u661f\u4f01\u4e1a\uff0c\u4e13\u6ce8\u4e8e\u4e3a\u57fa\u56e0\u7ec4\u5b9a\u4e49\u7684\u764c\u75c7\u60a3\u8005\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u9ad8\u9009\u62e9\u6027\u836f\u7269\uff1b\u516c\u53f8\u6838\u5fc3\u4ea7\u54c1Larotrectinib\uff08LOXO-101\uff09\u662f\u4e00\u79cd\u65b0\u4e00\u4ee3\u53ef\u53e3\u670d\u9ad8\u9009\u62e9\u6027\u916a\u6c28\u9178\u6fc0\u9176\u53d7\u4f53\uff08\u539f\u808c\u7403\u86cb\u767d\u53d7\u4f53\u6fc0\u9176\uff0cTropomyosin receptor kinase, TRK\uff09\u6291\u5236\u5242\uff0c\u8be5\u836f\u7684\u6700\u5927\u770b\u70b9\u5728\u4e8e\uff0c\u5b83\u662f\u4e00\u6b3e\u9488\u5bf9\u7279\u5b9a\u57fa\u56e0\u7a81\u53d8\uff0c\u800c\u4e0d\u9488\u5bf9\u7279\u5b9a\u764c\u75c7\u79cd\u7c7b\u7684\u6297\u764c\u65b0\u836f\uff1b\u76ee\u524d\u5df2\u7531\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u80bf\u7624\u75c5\u75c7\uff0c\u5305\u62ec\uff1a\u795e\u7ecf\u7ec6\u80de\u7624\u3001\u80ba\u764c\u3001\u7532\u72b6\u817a\u764c\u3001\u4e73\u817a\u764c\u7b49\u3002\u6b64\u5916\uff0cLoxo Oncology\u516c\u53f8\u8fd8\u9488\u5bf9\u7ecf\u7531\u9057\u4f20\u9014\u5f84\u8f6c\u79fb\u7684\u764c\u75c7\u60a3\u8005\u6765\u5f00\u53d1\u5176\u4ed6\u4ea7\u54c1\u9879\u76ee\u3002<\/span><\/p>\n

Loxo Oncology\u4e8e2013\u5e745\u67089\u65e5\u5728\u7f8e\u56fd\u7279\u62c9\u534e\u5dde\u6210\u7acb\uff0c\u516c\u53f8\u521b\u59cb\u4eba\u4e3aJoshua H. Bilenker\u535a\u58eb\uff0c2014\u5e748\u67081\u65e5\u5728\u7f8e\u56fd\u7eb3\u65af\u8fbe\u514b\uff08NASDAQ\uff09\u8bc1\u5238\u4ea4\u6613\u6240\u4e0a\u5e02\uff0c\u4e0a\u5e02\u52df\u96c6\u8d44\u91d16900\u4e07\u7f8e\u5143\uff1b\u516c\u53f8\u603b\u90e8\u8bbe\u5728\u7f8e\u56fd\u5eb7\u6d85\u72c4\u683c\u5dde\u7684\u65af\u5766\u798f\u5fb7\uff08Stamford\uff09\u3002\u516c\u53f8\u73b0\u4efb\u516c\u53f8\u603b\u88c1\u517c\u9996\u5e2d\u6267\u884c\u5b98\u4e3aJoshua H. Bilenker\uff0c2006\u5e74\uff0cJoshua H. Bilenker\u52a0\u5165\u7f8e\u56fd\u533b\u7597\u6295\u8d44\u516c\u53f8Aisling\uff0c\u76ee\u524d\u4ecd\u662f\u8be5\u6295\u8d44\u516c\u53f8\u7684\u5408\u4f19\u4eba\u3002Aisling\u4e5f\u662fLoxo\u7684\u65e9\u671f\u6295\u8d44\u4eba\uff0c\u9664\u4e86Aisling\u4e4b\u5916\uff0cLoxo\u7684\u6295\u8d44\u4eba\u8fd8\u5305\u62ecOrbiMed\u3001Array BioPharma Inc\u3001New Enterprise Associates\uff08NEA\uff09\u7b49\u3002\u521b\u59cb\u4eba\u6240\u5360\u80a1\u4efd\u5e76\u4e0d\u591a\uff0c\u4ec5\u67094.5%\u3002<\/span><\/p>\n

Loxo Oncology\u516c\u53f8\u65e9\u671f\u7684\u4e1a\u52a1\u4e3b\u8981\u662f\u4e0eArray BioPharma Inc\u8fdb\u884c\u5c0f\u5206\u5b50\u836f\u7269\u8054\u5408\u5f00\u53d1\uff0c\u8be5\u9879\u5408\u4f5c\u59cb\u4e8e2013\u5e747\u6708\uff0c\u5e76\u4e8e2013\u5e7411\u6708\u30012014\u5e744\u6708\u6269\u5927\u4e86\u5408\u4f5c\uff0c\u4e3b\u8981\u662f\u5173\u4e8eTRK\u6291\u5236\u5242\uff08\u5373LOXO101\uff09\uff0c\u6839\u636e\u534f\u8bae\uff0cArray\u5c06\u4e3aLoxo\u63d0\u4f9b\u5316\u5408\u7269\u8bbe\u8ba1\u3001\u5f00\u5c55\u548c\u8fdb\u884c\u7814\u7a76\u548c\u4e34\u5e8a\u524d\u6d4b\u8bd5\u670d\u52a1\u3002Loxo Oncology\u516c\u53f8\u73b0\u6709\u5168\u804c\u96c7\u545859\u4eba\uff0c\u516c\u53f8\u80a1\u4ef7233.250\u7f8e\u5143\uff082019\u5e741\u670817\u65e5\u6570\u636e\uff09\uff0c\u76ee\u524d\u603b\u5e02\u503c71.41\u4ebf\u7f8e\u5143\u3002Loxo Oncology\u516c\u53f8\u53d1\u5c55\u5386\u7a0b\u4e2d\u7684\u91cd\u8981\u91cc\u7a0b\u7891\u4e8b\u4ef6\u89c1\u56fe1\u3002<\/span><\/p>\n

\"Loxo<\/p>\n


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\u56fe1\uff1aLoxo Oncology\u516c\u53f8\u53d1\u5c55\u5386\u7a0b\u4e2d\u7684\u91cd\u8981\u91cc\u7a0b\u7891\u4e8b\u4ef6<\/span><\/p>\n

Loxo Oncology\u516c\u53f8\u4e13\u6ce8\u4e8e\u9488\u5bf9\u57fa\u56e0\u5b9a\u4e49\u764c\u75c7\u60a3\u8005\u7684\u9ad8\u5ea6\u9009\u62e9\u6027\u5c0f\u5206\u5b50\u836f\u7269\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u3002\u516c\u53f8\u6210\u7acb\u57fa\u4e8e\u4e24\u79cd\u79d1\u5b66\u7684\u8d8b\u52bf\uff1a\u2460\u764c\u75c7\u60a3\u8005\u7684\u4e34\u5e8a\u7ba1\u7406\u57fa\u56e0\u6d4b\u8bd5\u4f7f\u7528\u7684\u4e0d\u65ad\u589e\u52a0,\u5bfc\u81f4\u5f15\u8d77\u6b63\u5e38\u7ec6\u80de\u53d1\u751f\u764c\u53d8\u7684\u8bb8\u591a\u57fa\u56e0\u7f3a\u9677\u7684\u8bc6\u522b\uff1b\u2461\u6784\u5efa\u9488\u5bf9\u80bf\u7624\u7ec6\u80de\u5355\u4e00\u9776\u6807\u7684\u9ad8\u9009\u62e9\u6027\u7597\u6cd5\u7684\u5316\u5b66\u65b9\u6cd5\u7684\u4e0d\u65ad\u6539\u8fdb\u3002\u8fd9\u4e9b\u6d1e\u89c1\u4e3a\u7814\u7a76\u548c\u5f00\u53d1\u9488\u5bf9\u4e00\u4e9b\u6f5c\u5728\u57fa\u56e0\u7f3a\u9677\u7684\u65b0\u578b\u5b9a\u5236\u5019\u9009\u836f\u7269\u63d0\u4f9b\u4e86\u7edd\u597d\u7684\u673a\u4f1a\u3002\u516c\u53f8\u5f00\u53d1\u6709\u9488\u5bf9\u6027\u7684\u57fa\u56e0\u5b9a\u4e49\u7684\u60a3\u8005\u7fa4\u4f53\u7684\u7528\u4e8e\u80bf\u7624\u7cbe\u51c6\u6cbb\u7597\u7684\u5c0f\u5206\u5b50\u7597\u6cd5\u3002Loxo Oncology\u516c\u53f8\u4e13\u6ce8\u4e8e\u7531\u5355\u4e00\u975e\u6b63\u5e38\u7684DNA\u53d8\u5f02\u5373\u201c\u81f4\u764c\u57fa\u56e0\u9a71\u52a8\u201d\uff08Oncogenic driver\uff09\u5f15\u8d77\u7684\u764c\u75c7\u60a3\u8005\u6cbb\u7597\u65b9\u6cd5\u7684\u5f00\u53d1\uff0c\u5de5\u4f5c\u7684\u91cd\u70b9\u662f\u8fd9\u4e9b\u5355\u57fa\u56e0\u53d8\u5f02\uff0c\u901a\u8fc7\u6700\u5927\u9650\u5ea6\u5730\u8bbe\u8ba1\u9ad8\u9009\u62e9\u6027\u7684\u836f\u7269\uff0c\u8fd9\u6837\u4e00\u4e2a\u836f\u7269\u53ef\u80fd\u5bf9\u764c\u75c7\u6cbb\u7597\u6709\u610f\u60f3\u4e0d\u5230\u7684\u6548\u679c\u3002\u6b63\u5728\u56e0\u4e3a\u76f8\u4fe1\u57fa\u4e8e\u5355\u4e00\u76ee\u6807\u7684\u836f\u7269\u80fd\u591f\u4ee5\u6700\u5927\u7684\u53ef\u80fd\u6027\u6765\u6700\u5927\u9650\u5ea6\u5730\u6291\u5236\u5f71\u54cd\u901a\u8def\u3002Loxo Oncology\u516c\u53f8\u76f8\u4fe1\uff0c\u5f53\u4e00\u4e2a\u57fa\u56e0\u7ec4\u6d4b\u8bd5\u8bc6\u522b\u60a3\u8005\u80bf\u7624\u9020\u6210\u7684\u201c\u81f4\u764c\u57fa\u56e0\u9a71\u52a8\u201d\uff0c\u76f8\u5e94\u7684\u5e94\u8be5\u6709\u4e00\u4e2a\u5177\u6709\u9ad8\u5ea6\u9488\u5bf9\u6027\u7684\u836f\u7269\u5e94\u5bf9\u5bfc\u81f4\u764c\u75c7\u7684\u57fa\u56e0\u53d8\u5f02\u6f5c\u5728\u7684\u5f31\u70b9\u3002<\/span><\/p>\n

\t\u5728Loxo Oncology\u516c\u53f8\u7684\u6bcf\u4e2a\u4e34\u5e8a\u9879\u76ee\u90fd\u5fc5\u987b\u8fbe\u5230\u5982\u4e0b3\u4e2a\u6807\u51c6\uff1a\u2460\u9700\u6539\u9020\u95ee\u9898\u7684\u57fa\u56e0\u786e\u5b9a\u662f\u4e00\u4e2a\u81f4\u764c\u57fa\u56e0\uff0c\u2461\u9009\u62e9\u5f85\u5f00\u53d1\u7684\u836f\u7269\u5fc5\u987b\u662f\u6f5c\u5728\u7c7b\u578b\u4e2d\u6700\u597d\u7684\uff0c\u2462\u80fd\u591f\u8bc6\u522b\u5e76\u62db\u52df\u5230\u6070\u5f53\u7684\u60a3\u8005\u3002<\/span><\/p>\n

\t\u4e0e\u4e34\u5e8a3\u4e2a\u6807\u51c6\u76f8\u5bf9\u5e94\uff0cLoxo Oncology\u516c\u53f8\u6709\u81ea\u5df1\u72ec\u7279\u7684\u65b0\u53d1\u6a21\u5f0f\uff0c\u4e3b\u8981\u6309\u5982\u4e0b3\u4e2a\u6b65\u9aa4\u8fdb\u884c\uff1a\u2460\u9776\u70b9\u8bc6\u522b\u4e0e\u786e\u8ba4\uff0c\u2461\u5408\u9002\u836f\u7269\u7684\u6784\u5efa\uff0c\u2462\u5408\u9002\u60a3\u8005\u4eba\u7fa4\u7684\u9009\u62e9\u62db\u52df\u53ca\u5176\u4e34\u5e8a\u7814\u7a76\u3002\u5177\u4f53\u60c5\u51b5\u89c1\u56fe2\u6240\u793a\u3002<\/span><\/p>\n

\"Loxo <\/p>\n

\t\u56fe2\uff1aLoxo\u516c\u53f8\u65b0\u53d1\u6a21\u5f0f<\/span><\/p>\n

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\u516c\u53f8\u4ea7\u54c1<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

Loxo Oncology\u7ecf\u8fc75\u5e74\u591a\u7684\u4e0d\u61c8\u52aa\u529b\u7ec8\u4e8e\u8fce\u6765\u516c\u53f8\u7684\u9996\u4e2a\u836f\u7269\uff1aVitrakvi\uff08\u901a\u7528\u540dLarotrectinib\u62c9\u7f57\u66ff\u5c3c\uff0c\u7814\u53d1\u4ee3\u53f7LOXO-101\uff0c\u5316\u5b66\u7ed3\u6784\u89c1\u56fe3\uff09\u30022018\u5e7411\u670826\u65e5\uff0c\u7f8e\u56fdFDA\u540c\u610f\u52a0\u5feb\u6279\u51c6\u80bf\u7624\u836f\u7269Vitrakvi(\u62c9\u7f57\u66ff\u5c3c)\u7684\u4e0a\u5e02\u7533\u8bf7\u3002Vitrakvi\u662f\u7531Loxo Oncology\u548c\u62dc\u8033\uff08Bayer\uff09\u5171\u540c\u7814\u53d1\uff0c\u53ef\u7528\u4e8e\u6cbb\u7597\u643a\u5e26\u60a3\u6709\u795e\u7ecf\u8425\u517b\u6027\u916a\u6c28\u9178\u53d7\u4f53\u6fc0\u9176\uff08Neurotrophic tyrosine receptor kinase, NTRK\u5305\u62ecNTRK1\u3001NTRK2\u53caNTRK3\uff09\u57fa\u56e0\u878d\u5408\u7684\u5b9e\u4f53\u80bf\u7624\u60a3\u8005\uff08\u5305\u62ec\u6210\u4eba\u548c\u513f\u7ae5\uff09\uff0c\u5c24\u5176\u9002\u5408\u665a\u671f\u548c\u5df2\u7ecf\u53d1\u751f\u8f6c\u79fb\uff0c\u4e14\u624b\u672f\u98ce\u9669\u8f83\u5927\uff0c\u6ca1\u6709\u6709\u6548\u66ff\u4ee3\u6cbb\u7597\u65b9\u6848\u7684\u65e0\u8010\u836f\u6027\u7a81\u53d8\u60a3\u8005\u3002\u53ef\u6709\u6548\u6cbb\u7597\u7684\u764c\u75c7\u7c7b\u578b\u5305\u62ec\uff1a\u80ba\u764c\u3001\u7532\u72b6\u817a\u764c\u3001\u9ed1\u8272\u7d20\u7624\u3001\u80c3\u80a0\u764c\u3001\u7ed3\u80a0\u764c\u3001\u8f6f\u7ec4\u7ec7\u8089\u7624\u3001\u553e\u6db2\u817a\u3001\u5a74\u513f\u7ea4\u7ef4\u8089\u7624\u3001\u9611\u5c3e\u764c\u3001\u4e73\u817a\u764c\u3001\u80c6\u7ba1\u764c\u3001\u80f0\u817a\u764c\u7b4917\u79cd\uff0c\u4e14\u6709\u6548\u7387\u9ad8\u8fbe75%\u3002\u6b64\u6b21\u6279\u51c6\uff0c\u4f7fVitrakvi\u6210\u4e3a\u6709\u53f2\u4ee5\u6765\u7b2c\u4e00\u4e2a\u53e3\u670dTRK\uff08\u5305\u62ecTRKA\u3001TRKB\u548cTRKC\uff09\u6291\u5236\u5242\uff0c\u540c\u65f6\u4e5f\u662f\u7b2c\u4e00\u6b3e\u4e0e\u80bf\u7624\u7c7b\u578b\u65e0\u5173\uff08Tumor-agnostic\uff09\u7684\u201c\u5e7f\u8c31\u201d\u5c0f\u5206\u5b50\u9776\u5411\u6297\u764c\u836f\uff0c\u5c06\u5f00\u542f\u201cTumor agnostic\u201d\u6cbb\u7597\u65b0\u7eaa\u5143\u3002Vitrakvi\u7684\u83b7\u6279\u88ab\u8ba4\u4e3a\u662f\u764c\u75c7\u7597\u6cd5\u4ece\u201c\u57fa\u4e8e\u80bf\u7624\u5728\u4f53\u5185\u7684\u8d77\u6e90\u201d\u8f6c\u5411\u201c\u57fa\u4e8e\u80bf\u7624\u7684\u9057\u4f20\u7279\u5f81\u201d\u8fd9\u4e00\u6f14\u53d8\u8fc7\u7a0b\u4e2d\u7684\u91cd\u8981\u91cc\u7a0b\u7891\u3002\u4e4b\u524d\uff0cFDA\u5df2\u6388\u4e88Vitrakvi\u5b64\u513f\u836f\u8d44\u683c\u3001\u7f55\u89c1\u513f\u79d1\u75be\u75c5\u8d44\u683c\u3001\u7a81\u7834\u6027\u836f\u7269\u8d44\u683c\u3001\u4f18\u5148\u5ba1\u67e5\u8d44\u683c\u3002Vitrakvi\u4ef7\u683c\u4e0d\u83f2\uff0c\u6bcf\u5e74\u8d39\u7528\u9ad8\u8fbe40\u4e07\u7f8e\u5143\uff08\u6210\u4eba\u80f6\u56ca\u91c7\u8d2d\u8d39\u7528\uff1a\u6bcf\u670832,800\u7f8e\u5143\u7ea6\u5408\u4eba\u6c11\u5e0123\u4e07\u5143\uff1b\u513f\u7ae5\u53e3\u670d\u6db2\u914d\u65b9\u7684\u8d39\u7528\uff1a\u8d77\u4ef7\u4e3a\u6bcf\u670811,000\u7f8e\u5143\uff0c\u6839\u636e\u60a3\u8005\u7684\u8868\u9762\u79ef\u8ba1\u7b97\uff09\u3002<\/span>
<\/p>\n

Vitrakvi\u5177\u6709\u4e00\u5b9a\u7684\u809d\u6bd2\u6027\u3001\u795e\u7ecf\u6bd2\u6027\u3001\u548c\u80ce\u513f\u6bd2\u6027\u3002\u5df2\u53d1\u73b0\u8d85\u8fc720%\u7684\u53d7\u8bd5\u8005\u51fa\u73b0\u7684\u4e34\u5e8a\u526f\u53cd\u5e94\u6709\uff1a\u8c37\u8349\u8f6c\u6c28\u9176\u6216\u8c37\u4e19\u8f6c\u6c28\u9176\u5347\u9ad8\uff0c\u8d2b\u8840\u3001\u75b2\u52b3\uff0c\u6076\u5fc3\u7b49\uff0c\u6545\u540c\u65f6\u60a3\u6709\u809d\u810f\u75be\u75c5\u7684\u60a3\u8005\u7528\u836f\u8981\u683c\u5916\u8c28\u614e\u3002<\/span><\/p>\n

\"Loxo<\/p>\n

\t\u56fe3\uff1aLarotrectinib\uff08LOXO-101\uff09\u786b\u9178\u76d0\u5316\u5b66\u7ed3\u6784<\/span><\/p>\n

Larotrectinib\u6700\u521d\u4e8e\u7531Array BioPharma\u516c\u53f8\u5f00\u53d1\uff0c2013\u5e747\u6708Loxo Oncology\u4e0eArray BioPharma\u7b7e\u7f72\u4e86\u591a\u5e74\u6218\u7565\u5408\u4f5c\u534f\u8bae\uff0c\u6db5\u76d6Array\u53d1\u73b0\u7684\u591a\u4e2a\u4e34\u5e8a\u524d\u5019\u9009\u5316\u5408\u7269\uff0c\u5305\u62ecLarotrectinib\uff08\u5f53\u65f6\u53eb\u505aARRY-470\uff09\u30022017\u5e7411\u6708\uff0c\u62dc\u8033\u4e0eLoxo Oncology\u5c31Larotrectinib\u53ca\u53e6\u4e00\u79cdTRK\u6291\u5236\u5242LOXO-195\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u8fdb\u884c\u4e86\u72ec\u5bb6\u5168\u7403\u5408\u4f5c\uff0c\u603b\u91d1\u989d\u8fbe15.5\u4ebf\u7f8e\u5143\uff0c\u5728\u7f8e\u56fd\u5e02\u573a\uff0c\u53cc\u65b9\u5c06\u8054\u5408\u63a8\u5e7f\u4ea7\u54c1\u5e76\u5e73\u5206\u5229\u6da6\uff0c\u62dc\u8033\u5c06\u62e5\u6709\u8fd92\u4e2a\u4ea7\u54c1\u5728\u7f8e\u56fd\u4ee5\u5916\u5e02\u573a\u7684\u72ec\u5bb6\u5546\u4e1a\u5316\u6743\u76ca\u3002\u6839\u636e\u534f\u8bae\uff0cLoxo Oncology\u5c06\u83b7\u5f974\u4ebf\u7f8e\u5143\u7684\u9884\u4ed8\u6b3e\uff0c\u5e76\u4e14\u8fd8\u6709\u8d44\u683c\u83b7\u5f974.5\u4ebf\u7f8e\u5143\u7684\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u5f53Larotrectinib\u5728\u67d0\u4e9b\u4e3b\u8981\u5e02\u573a\u83b7\u5ba1\u6279\u901a\u8fc7\u548c\u9996\u6b21\u5546\u4e1a\u6027\u9500\u552e\u65f6\u3002\u62dc\u8033\u548cLoxo Oncology\u5c06\u8054\u5408\u5f00\u53d1Larotrectinib\u548cLOXO-195\uff0c\u5e76\u4ee550\/50\u7684\u6bd4\u4f8b\u5206\u644a\u5f00\u53d1\u6210\u672c\u3002<\/span><\/p>\n

\t\u4e0d\u540c\u4e8e\u4ee5\u5f80\u7684\u9776\u5411\u836f\u7269\uff0cLarotrectinib\u662f\u4f5c\u4e3a\u4e00\u6b3e\u5e7f\u8c31\u80bf\u7624\u836f\u6765\u5f00\u53d1\u3002\u5b83\u662f\u4e00\u79cd\u9ad8\u9009\u62e9\u6027\u808c\u7403\u86cb\u767d\u53d7\u4f53\u6fc0\u9176\uff08TRK\uff09\u6291\u5236\u5242\uff0c\u62df\u7528\u4e8e\u6240\u6709\u8868\u8fbe\u6709\u539f\u808c\u7403\u86cb\u767d\u53d7\u4f53\u6fc0\u9176\uff08TRK\uff09\u7684\u80bf\u7624\u60a3\u8005\uff0c\u800c\u4e0d\u662f\u9488\u5bf9\u67d0\u4e2a\u89e3\u5256\u4f4d\u7f6e\u7684\u80bf\u7624\uff0c\u8fd9\u5c31\u4f7f\u5f97\u5b83\u7684\u6cbb\u7597\u8303\u56f4\u975e\u5e38\u5e7f\u3002Larotrectinib\u4f5c\u7528\u7684\u9776\u70b9TRK\u878d\u5408\u7a81\u53d8\u5728\u51e0\u4e4e\u5404\u79cd\u764c\u75c7\u4e2d\u90fd\u6709\u53ef\u80fd\u53d1\u751f\uff0c\u636e\u4f30\u8ba1\uff0c\u8fd9\u79cd\u57fa\u56e0\u5f02\u5e38\u7684\u53d1\u751f\u5360\u5e38\u89c1\u80bf\u7624\u76840.5%~1%\uff0c\u4f46\u5728\u67d0\u4e9b\u7f55\u89c1\u80bf\u7624\u4e2d\u6240\u5360\u6bd4\u4f8b\u8d85\u8fc790%\uff0c\u4f8b\u5982\u553e\u6db2\u817a\u764c\u3001\u67d0\u79cd\u9752\u5e74\u578b\u4e73\u817a\u764c\u548c\u5a74\u513f\u578b\u7ea4\u7ef4\u8089\u7624\u4e2d\uff0cTRK\u878d\u5408\u5728\u80bf\u7624\u53d1\u751f\u65e9\u671f\u5373\u51fa\u73b0\uff0c\u5e76\u5728\u80bf\u7624\u751f\u957f\u548c\u64ad\u6563\u8fc7\u7a0b\u4e2d\u6301\u7eed\u5b58\u5728\u3002<\/span><\/p>\n

\t\u7eb5\u89c2\u5386\u53f2\uff0c\u81ea2016\u5e7412\u670818\u65e5\uff0cLoxo Oncology \u516c\u53f8\u7684TRK\u6291\u5236\u5242Larotrectinib\u9996\u6b21\u5728ESMO\u5927\u4f1a\u4e2d\u4e9a\u6d32\u2160\u671f\u8bd5\u9a8c\u7ed3\u679c\u6b63\u5f0f\u4eae\u76f8\uff0c\u5c55\u793a\u5176\u5bf9TRK\u878d\u5408\u80bf\u7624\u663e\u793a\u7684\u6301\u4e45\u6297\u80bf\u7624\u6d3b\u6027\u9707\u60ca\u4e86\u6574\u4e2a\u80bf\u7624\u4e1a\u754c\uff1b\u7d27\u63a5\u7740\uff0c\u57282017\u5e746\u6708\u7684\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u5e74\u4f1a\uff08ASCO\uff09\u4e0a\uff0cLarotrectinib\u516c\u5e03\u4e8655\u4f4dNTRK\u878d\u5408\u60a3\u8005\u7684\u4e34\u5e8a\u6570\u636e\uff0c\u6709\u6548\u7387\u9ad8\u8fbe75%\uff08\u8be5\u4e34\u5e8a\u6570\u636e\u53caFDA\u6587\u4ef6\u4e2d\u6240\u516c\u5e03\u7684\u6570\u636e\uff09\u3002\u65f6\u9694\u534a\u5e74\uff0c2018\u5e742\u670821\u65e5\u5728\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\uff08NEJM\uff09\u5728\u7ebf\u53d1\u8868\u4e86Larotrectinib\u540c\u65f6\u8fdb\u884c\u7684\u4e09\u9879\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u7814\u7a76\u7ed3\u679c\uff0c\u7814\u7a76\u663e\u793a\u5bf9\u4e8e\u5e74\u9f84\u4e3a4\u4e2a\u6708\u81f376\u5c81\u7684\u60a3\u8005\uff0c\u9488\u5bf917\u79cd\u4e0d\u540c\u764c\u75c7\u6cbb\u7597\u603b\u4f53\u53cd\u5e94\u7387\u4e3a75\uff05\u3002\u8fd9\u4e09\u9879\u7814\u7a76\u5305\u62ec\u6210\u4eba\u2160\u671f\u7814\u7a76\uff0c\u513f\u7ae5\u2160\/\u2161\u671f\u7814\u7a76\uff0c\u4ee5\u53ca\u9752\u5c11\u5e74\u548c\u6210\u4eba\u2161\u671f\u7814\u7a76\uff08NCT02122913\uff0cNCT02637687\u548cNCT02576431\uff09\u3002\u7ed3\u679c\u663e\u793a\uff0c\u65e0\u8bba\u60a3\u8005\u7684\u5e74\u9f84\u6216\u80bf\u7624\u7c7b\u578b\u5982\u4f55\uff0cLarotrectinib\u5bf9TRK\u878d\u5408\u9633\u6027\u7684\u764c\u75c7\u60a3\u8005\u5747\u5177\u6709\u660e\u663e\u4e14\u6301\u4e45\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002<\/span><\/p>\n

Larotrectinib\u7684\u4e34\u5e8a\u8bd5\u9a8c\u91c7\u7528\u4e86\u201c\u7bee\u5b50\u8bd5\u9a8c\u201d\uff08Basket trial\uff09\u7684\u8bd5\u9a8c\u8bbe\u8ba1\u3002\u5373\u4e0d\u6309\u7167\u60a3\u764c\u7ec4\u7ec7\u6765\u52df\u96c6\u60a3\u8005\uff0c\u800c\u662f\u6309\u7167\u80bf\u7624\u7684\u5206\u5b50\u7279\u5f81\u6765\u52df\u96c6\u60a3\u8005\u3002\u6839\u636e2018\u5e7410\u6708\u6b27\u6d32\u80bf\u7624\u5185\u79d1\u5b66\u4f1a\uff08ESMO2018\uff09\u5e74\u4f1a\u4e0a\u516c\u5e03\u7684\u6570\u636e\uff0c\u8fd9\u9879\u5173\u4e8eLarotrectinib\u6cbb\u759754\u540d\u53ef\u4ee5\u7528RECIST\u6807\u51c6\u8861\u91cf\u7684\u6db5\u76d624\u79cd\u72ec\u7279\u80bf\u7624\u7c7b\u578b\u7684TRK\u878d\u5408\u764c\u75c7\u6210\u4eba\u53ca\u513f\u7ae5\u60a3\u8005\u7684\u4e34\u5e8a\u6570\u636e\u663e\u793a\uff0c\u603b\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a80%\uff0c\u90e8\u5206\u7f13\u89e3\u7387\uff08PR\uff09\u4e3a62%\u3001\u5b8c\u5168\u7f13\u89e3\u7387\uff08CR\uff09\u4e3a18%\uff0c\u5728\u8865\u5145\u6570\u636e\u96c6\u4e2d\uff0cORR\u4e3a81%\u3001PR\u4e3a65%\u3001CR\u4e3a17%\u3002\u800c\u4e14\uff0c\u5176\u5728\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u4e2d\u7684\u8868\u73b0\u90fd\u975e\u5e38\u4e00\u81f4\u3002\u622a\u6b62\u5230\u76ee\u524d\uff0c\u603b\u5171109\u4f4dNTRK\u878d\u5408\u7684\u60a3\u8005\u7528\u8fc7Larotrectinib\uff0c\u603b\u4f53\u6709\u6548\u7387\u6781\u9ad8\u3002<\/span><\/p>\n

\u5f00\u5c55\u201c\u7bee\u5b50\u8bd5\u9a8c\u201d: \u4e0d\u7ba1\u80bf\u7624\u6765\u6e90\uff0c\u53ea\u8981\u53d1\u73b0\u6709TRK\u57fa\u56e0\u878d\u5408\u7a81\u53d8\uff0c\u5c31\u52a0\u5165\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u6d4b\u8bd5\u65b0\u836f\u7597\u6548\u3002\u7bee\u5b50\u8bd5\u9a8c\u662f\u9769\u547d\u6027\u7684\u6982\u5ff5\uff0c\u4f53\u73b0\u4e86\u764c\u75c7\u7cbe\u51c6\u533b\u7597\u7684\u4e00\u4e2a\u5de8\u5927\u8fdb\u6b65\u3002\u5982\u679c\u4e0d\u662fFDA\u548c\u5236\u836f\u516c\u53f8\u4e00\u8d77\u63a8\u52a8\u201c\u7bee\u5b50\u8bd5\u9a8c\u201d\u8bbe\u8ba1\u65b9\u6848\uff0cLarotrectinib\u4f30\u8ba1\u4f1a\u7531\u4e8e\u627e\u4e0d\u5230\u8db3\u591f\u591a\u60a3\u8005\u53c2\u4e0e\u8bd5\u9a8c\u800c\u80ce\u6b7b\u8179\u4e2d\uff0c\u6ca1\u6709\u673a\u4f1a\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u66f4\u6ca1\u6709\u673a\u4f1a\u4e0a\u5e02\u3002\u6211\u4eec\u81ea\u7136\u4e5f\u770b\u4e0d\u5230\u4eca\u5929\u8fd9\u4e2a\u60ca\u8273\u7684\u7ed3\u679c\u3002<\/span><\/p>\n

Larotrectinib\u5df2\u5728\u7f8e\u56fd\u5e02\u573a\u4e0a\u5e02\u3002\u540c\u65f6\u62dc\u8033\u516c\u53f8\u4e5f\u63d0\u4ea4\u4e86\u5728\u6b27\u76df\u7684\u4e0a\u5e02\u7533\u8bf7\uff0c\u76ee\u524d\u5c1a\u672a\u83b7\u5f97\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\u6279\u51c6\u3002\u6839\u636e\u6211\u56fd\u56fd\u5bb6\u836f\u76d1\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u7f51\u7ad9\u516c\u5f00\u4fe1\u606f\uff0c\u8be5\u836f\u54c1\u4ee5\u201c\u786b\u9178Larotrectinib\u80f6\u56ca\u201d\u4e3a\u540d\u79f0\u7684IND\u7533\u8bf7\u7531\u62dc\u8033\u516c\u53f8\u7533\u62a5\uff0c\u4e14\u5df2\u7ecf\u4e8e2019\u5e741\u670814\u65e5\u83b7\u53d7\u7406\u3002<\/span><\/p>\n

\t<\/span><\/p>\n

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03<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

\u7814\u53d1\u7ba1\u7ebf<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\u5728Loxo Oncology\u516c\u53f8\u7684\u7814\u53d1\u7ba1\u7ebf\u4e2d\uff0c\u6838\u5fc3\u8d44\u4ea7\u4ecd\u7136\u662f\u5f53\u521d\u4eceArray BioPharma\u6536\u8d2d\u6765\u7684\u5728\u7814\u836f\u7269\u3002\u7ecf\u8fc7\u6570\u5e74\u53d1\u5c55\uff0cLoxo Oncology\u516c\u53f8\u5728\u7814\u7ba1\u7ba1\u7ebf\u4e0d\u65ad\u58ee\u5927\uff0c\u5176\u4ea7\u54c1\u7ebf\u5305\u62ec\u5df2\u4e0a\u5e02\u7684\u7b2c\u4e00\u4ee3TRK\u6291\u5236\u5242Larotrectinib\uff08LOXO-101\uff09\u3001\u5904\u4e8e\u4e34\u5e8a\u2160\/\u2161\u671f\u7684\u7b2c\u4e8c\u4ee3TRK\u6291\u5236\u5242LOXO-195\u3001RET\u6fc0\u9176\u6291\u5236\u5242LOXO-292\u548cBTK\u975e\u5171\u4ef7\u6291\u5236\u5242LOXO-305\uff0c\u4ee5\u53ca\u5904\u4e8e\u4e34\u5e8a\u524d\u5f00\u53d1\u9636\u6bb5\u7684\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08Fibroblast growth factor receptor, FGFR\uff09\u9009\u62e9\u6027\u6291\u5236\u5242\uff08\u56fe4\uff09\u3002<\/span>
<\/p>\n

LOXO-101\uff08Larotrectinib\uff09\uff0c\u8fd9\u662f\u4e0e\u62dc\u8033\u516c\u53f8\u5408\u4f5c\u5f00\u53d1\u5e76\u5546\u4e1a\u5316\u7684\u4e00\u79cd\u53e3\u670dTRK\u6291\u5236\u5242\uff0c\u6700\u8fd1\u83b7\u5f97\u4e86FDA\u7684\u6279\u51c6\u3002\u5728\u83b7\u5f97FDA\u521d\u6b65\u6279\u51c6\u65f6\uff0cLarotrectinib\u662f\u7b2c\u4e00\u79cd\u80fd\u591f\u5728\u591a\u79cd\u764c\u75c7\u4e2d\u8d77\u6548\u7684\u57fa\u56e0\u5f02\u5e38\u5c0f\u5206\u5b50\u9776\u5411\u836f\u7269\u3002<\/span><\/p>\n

LOXO-195\uff0cLoxo Oncology\u548c\u62dc\u8033\u516c\u53f8\u4e5f\u5728\u7814\u7a76\u540e\u7eedTRK\u6291\u5236\u5242LOXO-195\u5bf9TRK\u6291\u5236\u7684\u8010\u836f\u6027\uff0c\u76ee\u524d\u5904\u4e8e\u4e34\u5e8a\u2160\/\u2161\u671f\u9636\u6bb5\u3002LOXO-195\u9488\u5bf9\u7684\u60a3\u8005\u4eba\u6570\u9884\u8ba1\u4f1a\u66f4\u5c11\uff0c\u76ee\u524d\u4ec5\u4e94\u4f4d\u60a3\u8005\u5165\u7ec4\uff0c\u5747\u6765\u81ea\u670d\u7528LOXO-101\u4ea7\u751f\u8010\u836f\u7684\u7fa4\u4f53\u3002\u8be5\u4ea7\u54c1\u6709\u671b\u4e8e2022\u5e74\u4e0a\u5e02\u3002<\/span><\/p>\n

LOXO-292\uff0cLOXO-292\u662f\u4e00\u79cd\u5f3a\u6548\u3001\u53e3\u670d\u3001\u9ad8\u5ea6\u9009\u62e9\u6027RET\uff08Rearranged during transfection\uff09\u6fc0\u9176\u6291\u5236\u5242\uff0c\u76ee\u524d\u5df2\u88abFDA\u6279\u51c6\u7528\u4e8e\u4e09\u79cd\u9002\u5e94\u75c7\u7684\u7a81\u7834\u6027\u6cbb\u7597\uff0c\u6709\u671b\u57282020\u5e74\u4e0a\u5e02\u3002LOXO-292\u9776\u5411\u4e8e\u8f6c\u67d3\u91cd\u6392\u57fa\u56e0\uff08RET\uff09\u6fc0\u9176\u671f\u95f4\u91cd\u7ec4\u7684\u764c\u75c7\u3002RET\u878d\u5408\u548c\u7a81\u53d8\u53d1\u751f\u5728\u591a\u79cd\u80bf\u7624\u7c7b\u578b\u4e2d\uff0c\u5305\u62ec\u67d0\u4e9b\u80ba\u764c\u548c\u7532\u72b6\u817a\u764c\u4ee5\u53ca\u5176\u4ed6\u764c\u75c7\u3002<\/span><\/p>\n

LOXO-305\uff0cLOXO-305\u662f\u4e00\u79cd\u53e3\u670dBTK\uff08Bruton’s tyrosine kinase\uff09\u6291\u5236\u5242\uff0c\u76ee\u524d\u5904\u4e8e\u2160\/\u2161\u671f\u3002LOXO-305\u901a\u8fc7\u6539\u53d8Bruton\u916a\u9178\u6fc0\u9176\u7684\u65b9\u5f0f\u5f71\u54cd\u764c\u75c7\u8fdb\u7a0b\uff0c\u65e8\u5728\u89e3\u51b3\u76ee\u524d\u53ef\u7528\u7684BTK\u6291\u5236\u5242\u83b7\u5f97\u7684\u8010\u836f\u6027\u3002BTK\u662f\u5728\u4f17\u591aB\u7ec6\u80de\u767d\u8840\u75c5\u548c\u6dcb\u5df4\u7624\u4e2d\u53d1\u73b0\u7684\u4e00\u79cd\u6709\u6548\u7684\u5206\u5b50\u9776\u70b9\u3002<\/span><\/p>\n

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04<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\n

\u5c0f\u7ed3<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

\u7b2c\u4e00\u4ee3TRK\u6291\u5236\u5242Larotrectinib\uff08LOXO-101\uff09\u6700\u521d\u7531Array BioPharma\u4e8e2008\u5e74\u5f00\u53d1\uff08US20080107616P\uff09\uff0c\u4ee3\u53f7\u4e3aARRY-470\uff0c\u4f46\u4e13\u5229\u91cc\u4e3b\u8981\u6d89\u53caCNS\u76f8\u5173\u75be\u75c5\uff08\u75bc\u75db\u3001AD\u7b49\uff0c\u8fd9\u4e5f\u4e0e\u5176\u673a\u5236\u76f8\u5173\uff09\u30022013\u5e747\u6708\uff0c\u6210\u7acb\u4e0d\u4e45\u7684Loxo Oncology\u516c\u53f8\u72ec\u5177\u6167\u773c\uff0c\u5f88\u5feb\u5c31\u548cArray\u8fbe\u6210\u4e86\u4e00\u9879\u591a\u5e74\u6218\u7565\u5408\u4f5c\uff0c\u4e3b\u8981\u9488\u5bf9TRK\u6291\u5236\u5242\uff08Larotrectinib\uff09\u7684\u80bf\u7624\u7cbe\u51c6\u7597\u6cd5\uff0c\u4e4b\u540eLarotrectinib\u542f\u52a8\u5f00\u6302\u6a21\u5f0f\uff0c\u4e34\u5e8a\u9053\u8def\u4e00\u8def\u7545\u901a\uff0c\u5e76\u57282018\u5e7411\u6708\u7531\u7f8e\u56fdFDA\u83b7\u6279\u4e0a\u5e02\u3002<\/span>
<\/p>\n

Loxo Oncology\u516c\u53f8\u836f\u7269\u7814\u53d1\u7684\u601d\u8def\u662f\u975e\u5e38\u524d\u6cbf\u3001\u9ad8\u5ea6\u521b\u65b0\u7684\uff0c\u800c\u4f01\u4e1a\u6574\u5408\u4f18\u52bf\u8d44\u6e90\u4e3a\u521b\u65b0\u8d4b\u80fd\uff0c\u65b9\u662f\u4ea7\u54c1\u5feb\u901f\u5546\u4e1a\u5316\u7684\u6700\u4f18\u89e3\uff0cLoxo Oncology\u6b63\u662f\u8fd9\u6837\u7684\u6210\u529f\u8303\u4f8b\uff1b\u5176\u9664\u4e86\u4ee5\u654f\u9510\u7684\u79d1\u5b66\u773c\u5149\u6536\u8d2d\u5e76\u53d1\u6398Array Pharma\u7684\u4ea7\u54c1\u5916\uff0c\u8fd8\u540c\u8bca\u65ad\u6280\u672f\u516c\u53f8Veracyte\u548cIllumina\u8fbe\u6210\u5408\u4f5c\u3002Loxo Oncology\u5229\u7528\u5408\u4f5c\u4f19\u4f34\u5148\u8fdb\u7684\u8bca\u65ad\u6280\u672fAfirma Xpression Atlas\u548cTruSight Tumor 170\u5e73\u53f0\u4e3a\u70b9\u7a81\u53d8\u3001\u878d\u5408\u3001\u6269\u589e\u548c\u526a\u63a5\u53d8\u5f02\u7684\u60a3\u8005\u63d0\u4f9b\u4f34\u968f\u8bca\u65ad\uff0c\u4ece\u800c\u53ef\u4ee5\u51c6\u786e\u5730\u4e86\u89e3\u54ea\u4e9b\u60a3\u8005\u53ef\u80fd\u53d7\u76ca\u3002\u8fd9\u4e0d\u4ec5\u4e3a\u6539\u5584\u665a\u671f\u764c\u75c7\u60a3\u8005\u7684\u751f\u6d3b\u521b\u9020\u4e86\u65b0\u7684\u673a\u4f1a\uff0c\u4e5f\u540c\u65f6\u4e5f\u5b9e\u73b0\u4e86\u81ea\u8eab\u7684\u7ecf\u6d4e\u5229\u76ca\u3002<\/span><\/p>\n

\n

\t\u6ce8\uff1a*\u7531\u62dc\u8033\u8d1f\u8d23\u5e02\u573a\u63a8\u5e7f\uff0c**\u7531Loxo Oncology\u548c\u62dc\u8033\u5171\u540c\u63a8\u5e7f<\/span><\/p>\n

\t\u56fe4\uff1aLoxo\u516c\u53f8\u65b0\u53d1\u7ba1\u7ebf<\/span><\/p>\n

\t\u764c\u75c7\u6cbb\u7597\u5df2\u7ecf\u8d70\u5165\u4e86\u7cbe\u51c6\u533b\u7597\uff08Precision medicine\uff09\u65f6\u4ee3\uff0c\u800c\u7cbe\u51c6\u533b\u7597\u7684\u4e00\u4e2a\u91cd\u8981\u7279\u5f81\u5c31\u662f\u57fa\u4e8e\u60a3\u8005\u7684\u80bf\u7624\u7279\u6027\u6765\u9009\u62e9\u9776\u5411\u836f\u7269\u3002\u867d\u7136Loxo Oncology\u516c\u53f8\u7684\u7814\u53d1\u7ba1\u7ebf\u4e2d\u7684\u83b7\u6279\u548c\u5728\u7814\u5019\u9009\u836f\u7269\u4ea7\u54c1\u9488\u5bf9\u7684\u60a3\u8005\u7fa4\u53ea\u5360\u764c\u75c7\u60a3\u8005\u603b\u6570\u5f88\u5c0f\u4e00\u90e8\u5206\uff0c\u4f46\u662f\u8be5\u516c\u53f8\u9488\u5bf9\u60a3\u8005\u80bf\u7624\u4e2d\u7684\u7279\u5b9a\u57fa\u56e0\u7279\u5f81\u5f00\u53d1\u9ad8\u5ea6\u7279\u5f02\u6027\u7597\u6cd5\u7684\u836f\u7269\u7684\u5f00\u53d1\u7b56\u7565\u5df2\u7ecf\u5f97\u5230\u4e86\u8ba4\u53ef\u3002\u5176\u5b83\u533b\u836f\u516c\u53f8\u4e5f\u5728\u5f00\u53d1\u9488\u5bf9\u7279\u5b9a\u57fa\u56e0\u53d8\u5f02\u7684\u9776\u5411\u7597\u6cd5\uff0c\u800c\u4e0d\u4f9d\u9760\u764c\u75c7\u5728\u8eab\u4f53\u4e2d\u53d1\u751f\u7684\u90e8\u4f4d\uff0c\u800c\u4f9d\u9760\u764c\u75c7\u57fa\u56e0\u7279\u5f81\u62db\u52df\u60a3\u8005\u8fdb\u884c\u7684\u201c\u7bee\u5b50\u8bd5\u9a8c\u201d\u4e5f\u6b63\u5728\u6210\u4e3a\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7684\u4e00\u79cd\u91cd\u8981\u8bd5\u9a8c\u8bbe\u8ba1\u65b9\u5f0f\u3002\u793c\u6765\u516c\u53f8\u9009\u62e9Loxo Oncology\u516c\u53f8\u4f5c\u4e3a\u5e76\u8d2d\u5bf9\u8c61\u4e5f\u662f\u5bf9\u8fd9\u4e00\u7cbe\u51c6\u533b\u7597\u7b56\u7565\u7684\u80af\u5b9a\uff0c\u53ef\u4ee5\u8bf4\u5929\u65f6\u3001\u5730\u5229\u3001\u4eba\u548c\u9020\u5c31\u4e86\u73b0\u4eca\u7684Loxo\u3002<\/span><\/p>\n

\t\u81ea\u4ece1982\u5e74NTRK\u88abMariano Barbacid\u548c\u540c\u4e8b\u4eec\u53d1\u73b0\u4e3a\u81f4\u764c\u57fa\u56e0\uff0c\u52302018\u5e7411\u6708\u65b0\u836fVitrakvi\u95ee\u4e16\uff0c\u5df2\u7ecf\u8fc7\u53bb\u4e8636\u5e74\u3002\u671f\u5f85\u8be5\u836f\u5728\u6211\u4eec\u56fd\u5185\u80fd\u65e9\u65e5\u83b7\u6279\uff0c\u518d\u7eb3\u5165\u533b\u4fdd\uff0c\u8ba9\u66f4\u591a\u60a3\u8005\u4eba\u7fa4\u53d7\u76ca\u3002<\/span><\/p>\n


<\/p>\n

\u3010\u53c2\u8003\u8d44\u6599\u3011<\/span><\/p>\n

1. Loxo Oncology\u516c\u53f8\u5b98\u7f51. https:\/\/www.loxooncology.com\/.<\/span><\/p>\n

\t2. VITRAKVI\u00ae\u5b98\u7f51. https:\/\/www.hcp.vitrakvi-us.com\/.<\/span><\/p>\n

\t3. Loxo Oncology\u516c\u53f8\u7814\u53d1\u7ba1\u7ebf\uff1ahttps:\/\/www.loxooncology.com\/pipeline.<\/span><\/p>\n

\t4. \u79d1\u777f\u552f\u5b89Integrity\u6570\u636e\u5e93, \u68c0\u7d22\u65e5\u671f: 2019\u5e741\u670817\u65e5.<\/span><\/p>\n

5. Informa\u6570\u636e\u5e93, \u68c0\u7d22\u65e5\u671f: 2018\u5e7411\u670828\u65e5.<\/span><\/p>\n

6. Drilon A, Laetsch TW, Kummar S, et al. Efficacy of larotrectinib in TRK fusion\u2013positive cancers in adults and children. N Engl J Med, 2018, 378: 731-739.<\/span><\/p>\n

\t7. Subbiah V, Velcheti V, Tuch B B, et al. Selective RET kinase inhibition for patients with RET-altered cancers. Annals of Oncology, 2018, 29: 1869-1876.<\/span><\/p>\n

\t8. Drilon A, Nagasubramanian R, Blake JF, et al. A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors. Cancer Discovery, 2017, 7: 963-972. <\/span><\/p>\n


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