{"id":78289,"date":"2019-01-23T00:00:50","date_gmt":"2019-02-01T06:15:33","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/78289\/"},"modified":"2019-02-01T14:15:33","modified_gmt":"2019-02-01T06:15:33","slug":"b1189699e9","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/78289\/","title":{"rendered":"\u7cd6\u5c3f\u75c5\u73b0\u6709\u836f\u7269\u7684\u4e2a\u6027\u5316\u7814\u7a76\u8fdb\u5c55"},"content":{"rendered":"
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01<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u6d41\u884c\u75c5\u5b66\u53ca\u7814\u7a76\u73b0\u72b6<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

2017\u5e7412\u6708\uff0c\u56fd\u9645\u7cd6\u5c3f\u75c5\u8054\u76df\uff08IDF\uff09\u53d1\u5e03\u4e86\u5168\u7403\u7b2c\u516b\u7248\u7cd6\u5c3f\u75c5\u5730\u56fe\u3002\u6839\u636eIDF\u6570\u636e\u663e\u793a\uff0c\u5168\u7403\u7cd6\u5c3f\u75c5\u6210\u4eba\u60a3\u8005\u8fbe4.25\u4ebf\uff0c\u5e73\u5747\u6bcf11\u4e2a\u4eba\u4e2d\u5c31\u67091\u4f4d\u60a3\u8be5\u75c5\u3002\u5176\u4e2d\uff0c\u4e2d\u56fd\u60a3\u75c5\u4eba\u6570\u8fbe1.14\u4ebf\u4eba\uff0c\u7cd6\u5c3f\u75c5\u8d1f\u62c5\u6700\u91cd\u3002<\/span><\/p>\n

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02<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8fd1\u671f\uff0c2016\u5e748\u6708\u300aNature Genetics\u300b\u6742\u5fd7\u62a5\u9053\u4e86\u4e00\u987913123\u540d\u53c2\u4e0e\u8005\u7684\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u5206\u6790\uff0c\u7ed3\u679c\u8868\u660eSLC2A2\u57fa\u56e0\u7684\u7a81\u53d8\u4e0e\u66f4\u5f3a\u7684\u4e8c\u7532\u53cc\u80cd\u54cd\u5e94\u6709\u5173\uff0c\u8fd9\u4e00\u57fa\u56e0\u7f16\u7801\u4e86\u4e00\u79cd\u53eb\u505aGLUT2\u7684\u8461\u8404\u7cd6\u8f6c\u8fd0\u86cb\u767d\uff1b2016\u5e743\u6708\u300aScientific Reports\u300b\u6742\u5fd7\u62a5\u9053\u4e8c\u7532\u53cc\u80cd\u901a\u8fc7PPAR\u03b1\u523a\u6fc0IGFBP-2\u57fa\u56e0\u7684\u8868\u8fbe\u4f5c\u7528\u4e8e\u7cd6\u5c3f\u75c5\u3002<\/span><\/p>\n

\u567b\u5511\u70f7\u4e8c\u916e\u7c7b<\/span><\/strong><\/p>\n

\u567b\u5511\u70f7\u4e8c\u916e\u7c7b\uff08thiazolidinediones\uff0cTZDs\uff09\u964d\u7cd6\u836f\u5c5e\u80f0\u5c9b\u7d20\u589e\u654f\u5242\uff0c\u5b83\u4eec\u4fc3\u8fdb\u7ec4\u7ec7\u548c\u9aa8\u9abc\u808c\u8461\u8404\u7cd6\u6444\u53d6\uff0c\u4e0b\u8c03\u8461\u8404\u7cd6\u4ece\u809d\u810f\u8f93\u51fa\u3002\u76ee\u524d\u4e34\u5e8a\u5e94\u7528\u7684\u4e3b\u8981\u4e3a\u5421\u683c\u5217\u916e\u548c\u7f57\u683c\u5217\u916e\u3002TZDs\u4e3b\u8981\u901a\u8fc7\u6fc0\u6d3bPPAR\u03b3\uff0c\u5f71\u54cd\u80f0\u5c9b\u7d20\u76f8\u5173\u4fe1\u53f7\u901a\u8def\uff0c\u589e\u52a0\u80f0\u5c9b\u7d20\u654f\u611f\u6027\u3002PPAR\u03b3\u57fa\u56e0\u5355\u6838\u82f7\u9178\u53d8\u5f02\u53ef\u80fd\u4f1a\u5f71\u54cd\u4e0eTZDs\u7ed3\u5408\u7684\u4eb2\u548c\u529b\u53ca\u5176\u6cbb\u7597\u6548\u679c\u3002Priya\u7b49\u53d1\u73b0\u62e5\u6709PPAR\u03b3\u57fa\u56e0Pro12Ala\u53d8\u5f02\u76842\u578b\u7cd6\u5c3f\u75c5\u4eba\u4e0e\u91ce\u751f\u578b\u57fa\u56e0\u643a\u5e26\u8005\u76f8\u6bd4\u5728\u7f57\u683c\u5217\u916e\u6cbb\u7597\u8868\u73b0\u51fa\u663e\u8457\u8840\u7cd6\u63a7\u5236\u76f8\u5173\u6027\u3002<\/span><\/p>\n

\u800c\u5728\u4e2d\u56fd\u75c5\u4eba\u4e2d\uff0cPPAR\u03b3\u5171\u6fc0\u6d3b\u56e0\u5b501-\u03b1\u7684\u6c28\u57fa\u9178\u53d8\u5f02\u4f53Thr394Thr\u548cGly482Ser\u4e5f\u4e0e\u7f57\u683c\u5217\u916e\u7684\u6cbb\u7597\u6548\u679c\u663e\u8457\u76f8\u5173\u3002\u6b64\u5916\uff0c\u809d\u810f\u4ee3\u8c22\u9176\u76f8\u5173\u57fa\u56e0CYP2C8\uff0cCYP2C9\uff0cGSTT1\uff0cGSTM1\u4ee5\u53caADIPOQ\u57fa\u56e0\u7684SNP\u5747\u4e0eTZDs\u964d\u7cd6\u6548\u679c\u6709\u660e\u663e\u7684\u5173\u7cfb\u3002\u8fd1\u671f\u7814\u7a76\u53d1\u73b0\uff0c\u7531SLCO1B1\u548cCYP2C8\u7f16\u7801\u7684OATP1B1\u9664\u4e86\u5f71\u54cdTZDs\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u5916\uff0c\u9488\u5bf9833\u540d\u82cf\u683c\u5170\u60a3\u8005\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76\u8868\u660eCYP2C8*3\u548cOATP1B1\u975e\u540c\u4e49\u53d8\u4f53\uff08Val174Ala\uff0crs4149056\uff09\u6539\u53d8\u836f\u7269\u7597\u6548\u3002<\/span><\/p>\n

DPP-4\u6291\u5236\u5242<\/span><\/strong><\/span><\/p>\n

DPP-4\u662f\u4e00\u79cd\u591a\u529f\u80fd\u86cb\u767d\u6c34\u89e3\u9176\uff0c\u80fd\u7279\u5f02\u6027\u7684\u8bc6\u522bN-\u7aef\u7b2c\u4e8c\u4f4d\u662f\u812f\u6c28\u9178\u6216\u4e19\u6c28\u9178\u7684\u591a\u80bd\u7c7b\u5e95\u7269\u5982GLP-1\u548cGIP-1\uff0c\u4f7f\u5176\u8f6c\u5316\u6210\u65e0\u6d3b\u6027\u7684\u4ea7\u7269\u3002\u901a\u8fc7DPP-4\u6291\u5236\u5242\u53ef\u6709\u6548\u589e\u52a0\u5185\u6e90\u6027GLP-1\u6c34\u5e73\uff0c\u4ece\u800c\u589e\u5f3a\u80a0\u4fc3\u80f0\u5c9b\u7d20\u5206\u6ccc\u4f5c\u7528\uff0c\u5e76\u5ef6\u957f\u6d3b\u6027\u80a0\u4fc3\u80f0\u5c9b\u7d20\u7684\u8461\u8404\u7cd6\u8c03\u8282\u4f5c\u7528\u3002<\/span><\/p>\n

DPP-4\u57fa\u56e0\u4f4d\u4e8e\u4eba\u7c7b2\u53f7\u67d3\u8272\u4f53\u957f\u81c2\u768424\u533a3\u5e26\uff082q 24.3\uff09\uff0c\u957f\u5ea6\u7ea6\u4e3a70kb\uff0c\u5305\u62ec26\u4e2a\u5916\u663e\u5b50\u548c25\u4e2a\u5185\u542b\u5b50\u3002DPP-4\u4e3a\u8de8\u819c\u7cd6\u86cb\u767d\uff0c\u5176\u76f8\u5bf9\u5206\u5b50\u91cf\u4e3a110kda\uff0c\u7531766\u4e2a\u6c28\u57fa\u9178\u7ec4\u6210\uff0c\u5305\u62ec6\u4e2a\u80de\u8d28\u5185\u6c28\u57fa\u9178\u300122\u4e2a\u8de8\u819c\u6c28\u57fa\u9178\u6b8b\u57fa\u548c738\u4e2a\u80de\u8d28\u5916\u6c28\u57fa\u9178\u6b8b\u57fa\u3002<\/span><\/p>\n

DPP-4\u57fa\u56e0\u591a\u6001\u6027\u4e3b\u8981\u662f\u5355\u6838\u82f7\u9178\u591a\u6001\u6027\uff0cDPP-4\u57fa\u56e0\u4e2d\u5b58\u5728\u591a\u4e2aSNP\u4f4d\u70b9\uff1a\u4f4d\u4e8e\u5916\u663e\u5b502\u7684c.24 T>C(rs17848915)\uff1b\u4f4d\u4e8e\u5916\u663e\u5b5010\u7684c.796 G>A\uff1b\u4f4d\u4e8e\u5916\u663e\u5b5014\u7684c.1926 G>A\uff1b\u4f4d\u4e8e\u5185\u542b\u5b509\u768454 C>A(RS2302872)\uff1b\u4f4d\u4e8e\u5185\u542b\u5b509\u768412 G>T(rs1558957)\uff1b\u4f4d\u4e8e\u975e\u7f16\u7801\u533a5\u2019\u7aef\u7684c.234 G>A(rs13015258)\uff1b\u4f4d\u4e8e\u975e\u7f16\u7801\u53bb3\u2019\u7aef\u7684c.2467 G>A\u7b49\u7b49\uff0c\u4e14\u57fa\u56e0\u591a\u6001\u6027\u7684\u5206\u5e03\u5728\u4e0d\u540c\u4eba\u7fa4\u4e2d\u5e76\u4e0d\u76f8\u540c\u3002\u4e34\u5e8a\u7814\u7a76\u8bc1\u5b9e\uff0cDPP-4\u57fa\u56e0SNP\u4f4d\u70b9\u5982rs17848915\u3001rs7608798\u3001rs4664443\u548crs3788979\u7b49\u53ef\u4ee5\u5f71\u54cd\u60a3\u8005\u81ea\u8eab\u7684\u8840\u8102\u6c34\u5e73\u548c\u5fc3\u8840\u7ba1\u98ce\u9669\uff0c\u4e14\u5177\u6709\u9ad8\u5ea6\u7684\u591a\u6001\u6027\uff0c\u5728\u4eba\u7fa4\u4e2d\u5206\u5e03\u5e7f\u6cdb\uff1b\u5916\u663e\u5b50\u7a81\u53d8rs13015258\u548crs17848915\u53ef\u5f71\u54cdDPP-4\u7684mRNA\u8868\u8fbe\u6c34\u5e73\uff0c\u4f5c\u7528\u9776\u70b9\u7684\u86cb\u767d\u7ed3\u6784\u6539\u53d8\u53ef\u80fd\u5f71\u54cdDPP-4\u6291\u5236\u5242\u7684\u836f\u7406\u4f5c\u7528\u3002<\/span><\/p>\n

\u03b1-\u7cd6\u82f7\u9176\u6291\u5236\u5242<\/span><\/strong><\/span><\/p>\n

\u963f\u5361\u6ce2\u7cd6\u5c5e\u4e8e\u03b1-\u7cd6\u82f7\u9176\u6291\u5236\u5242\uff0c\u03b1-\u7cd6\u82f7\u9176\u6291\u5236\u5242\u53ef\u4ee5\u901a\u8fc7\u53ef\u9006\u6027\u7684\u7ade\u4e89\u03b1-\u7cd6\u82f7\u9176\u4e0e\u7cd6\u7684\u7ed3\u5408\u4f4d\u70b9\uff0c\u9650\u5236\u6216\u5ef6\u7f13\u78b3\u6c34\u5316\u5408\u7269\u7684\u80a0\u5185\u5206\u89e3\u548c\u5438\u6536\uff0c\u4ece\u800c\u51cf\u7f13\u80a0\u9053\u5185\u8461\u8404\u7cd6\u7684\u5438\u6536\uff0c\u964d\u4f4e\u9910\u540e\u9ad8\u8840\u7cd6\u75c7\u72b6\u3002\u03b1-\u7cd6\u82f7\u9176\u57fa\u56e0\u672c\u8eab\u7a81\u53d8\u5bf9\u03b1-\u7cd6\u82f7\u9176\u6291\u5236\u5242\u7684\u4f5c\u7528\u5e76\u6ca1\u6709\u6587\u732e\u62a5\u9053\uff0c\u4f462005\u5e74\uff0cAndrulionyt\u00e8 L\u7b49\u4eba\u53d1\u73b0\u963f\u5361\u6ce2\u7cd6\u53ef\u660e\u663e\u6cbb\u7597\u7cd6\u5c3f\u75c5\uff0c\u4e14\u4e0d\u4f9d\u8d56\u4e8ePPAR-\u03b32\u57fa\u56e0\uff0c\u540c\u65f6\u963f\u5361\u6ce2\u7cd6\u7684\u9002\u5e94\u4eba\u7fa4\u662f\u643a\u5e26\u672a\u7a81\u53d8\u7684482Ser\u7684PGC1-\u03b1\u57fa\u56e0\u3002\u6b64\u5916\uff0c\u4e00\u9879STOP-NIDDM\u8bd5\u9a8c\u63ed\u793aPPARA\uff08PPAR-alpha\uff09\u3001PPARG2\uff08PPAR-gamma2\uff09\u3001PPARGC1A\uff08PPAR-gamma coactivator 1alpha\uff09\u548cHNF4A\uff08hepatic nuclear factor 4alpha\uff09\u4e0e\u963f\u5361\u6ce2\u7cd6\u5b58\u5728\u76f8\u4e92\u5de6\u53f3\uff0c\u4f46\u8fd9\u4e9b\u5fae\u5f31\u7684\u5173\u8054\u7684\u4e34\u5e8a\u610f\u4e49\u5c1a\u5f85\u68c0\u9a8c\u3002<\/span><\/p>\n

\u78fa\u8132\u7c7b\u836f\u7269<\/span><\/strong><\/span><\/p>\n

\u78fa\u9170\u8132\u7c7b\u836f\u7269\uff08sulfonylureas\uff0cSU\uff09\u662f\u6cbb\u7597\u975e\u80a5\u80d62\u578b\u7cd6\u5c3f\u75c5\u75c5\u4eba\u7684\u6700\u65e9\u3001\u54c1\u79cd\u6700\u591a\u3001\u4e34\u5e8a\u5e94\u7528\u6700\u5e7f\u6cdb\u7684\u4e00\u7ebf\u5e94\u7528\u53e3\u670d\u964d\u7cd6\u836f\u836f\u7269\uff08\u6700\u8fd1\u5df2\u6210\u4e3a\u4e8c\u7ebf\u6216\u8f85\u52a9\u6cbb\u7597\u836f\u7269\uff09\u3002<\/span><\/p>\n

\u5728\u836f\u6548\u5b66\u65b9\u9762\uff0c\u78fa\u9170\u8132\u7c7b\u836f\u7269\u4e3b\u8981\u5728\u80f0\u817a\u03b2\u7ec6\u80de\u4e2d\u901a\u8fc7\u8461\u8404\u7cd6\u4f20\u611f\u673a\u5236\u4e2d\u7684\u4e09\u78f7\u9178\u817a\u82f7\uff08ATP\uff09\u4f9d\u8d56\u7684K+\u901a\u9053\uff08KATP\uff09\u4ecb\u5bfc\u80f0\u5c9b\u7d20\u91ca\u653e\u3002KATP\u901a\u9053\u662f\u7531ATP\u7ed3\u5408\u76d2\u8f6c\u8fd0\u4f53\u5bb6\u65cfC8\uff08ABCC8\uff09\u57fa\u56e0\u7f16\u7801\u76844\u4e2a\u80de\u5916\u78fa\u9170\u8132\u7c7b\u53d7\u4f531\uff08SUR1\uff09\u4e9a\u5355\u4f4d\u548c\u7531\u7535\u538b\u95e8\u63a7\u94be\u901a\u9053\u4e9a\u5bb6\u65cfJ11\uff08KCNJ11\uff09\u57fa\u56e0\u7f16\u7801\u76844\u4e2a\u80de\u5185Kir6.2\uff08KCNJ11\u57fa\u56e0\u540c\u79f0\u8c13\uff09\u4e9a\u5355\u4f4d\u7ec4\u6210\u7684\u516b\u805a\u4f53\uff0cSUR1\u548cKir6.2\u5206\u522b\u662f\u78fa\u8132\u7c7b\/\u7f8e\u683c\u5217\u8132\u7c7b\u836f\u7269\u7684\u7ed3\u5408\u4f4d\u70b9\u3002KCNJ11\u57fa\u56e0\u5177\u6709\u591a\u6001\u6027\uff0c\u76ee\u524d\u5df2\u7ecf\u62a5\u9053\u6709219\u4e2aSNP\u4f4d\u70b9\u3002\u5176\u4e2d\u53ea\u67096\u4e2aSNP\u4f4d\u70b9\uff08rs5210\uff0crs5215\uff0crs5218\uff0crs5219\uff0crs886288\uff0crs2285676\uff09\u53d1\u73b0\u4e0e\u7cd6\u5c3f\u75c5\u6709\u5173\u3002<\/span><\/p>\n

\u5728\u836f\u52a8\u5b66\u65b9\u9762\uff0c\u78fa\u8132\u7c7b\u836f\u7269\u4e3b\u8981\u7531\u7ec6\u80de\u8272\u7d20CYP2C9\u9176\u4ee3\u8c22\u3002CYP2C9*2\uff08Arg144Cys\uff09\u548cCYP2C9 *2\uff08Ile359Leu\uff09\u662f\u4eba\u7c7b\u4e2d\u4e3b\u8981\u7684CYP2C9\u53d8\u4f53\uff0c\u56e0\u6b64\u78fa\u8132\u7c7b\u836f\u7269\u7597\u6548\u4e5f\u4e0eCYP2C9\u57fa\u56e0\u591a\u6001\u6027\u76f8\u5173\u3002<\/span><\/p>\n

\u5217\u5948\u7c7b<\/span><\/strong><\/span><\/p>\n

\u7f8e\u683c\u5217\u5948\uff08Meglitinides\uff09\u3001\u745e\u683c\u5217\u5948\uff08repaglinide\uff09\u548c\u90a3\u683c\u5217\u5948\uff08nateglinide\uff09\u662f\u4e00\u79cd\u77ed\u6548\u7684\u8461\u8404\u7cd6\u91ca\u653e\u836f\u7269\uff0c\u8be5\u7c7b\u836f\u7269\u5728\u7ed3\u6784\u4e0a\u4e0d\u540c\u4e8e\u78fa\u9170\u8132\u7c7b\u836f\u7269\uff0c\u901a\u8fc7\u4e0d\u540c\u7684\u80f0\u817a\u03b2\u7ec6\u80de\u53d7\u4f53\u53d1\u6325\u4f5c\u7528\uff0c\u4f46\u5b83\u4eec\u901a\u8fc7\u8c03\u8282\u80f0\u817a\u03b2\u7ec6\u80de\u4e2d\u7684ATP\u654f\u611f\u6027\u94be\u901a\u9053\uff08K-ATP\u901a\u9053\uff09\u53d1\u6325\u7c7b\u4f3c\u4f5c\u7528\uff0c\u4ece\u800c\u589e\u52a0\u80f0\u5c9b\u7d20\u5206\u6ccc\u3002\u7f8e\u683c\u5217\u5948\u8d77\u6548\u5feb\uff0c\u4f5c\u7528\u65f6\u95f4\u77ed\u3002<\/span><\/p>\n

\u8be5\u7c7b\u836f\u7269\u901a\u8fc7SLCO1B1\u7f16\u7801\u7684OATP1B1\u8f6c\u8fd0\u5230\u809d\u810f\uff0c\u4e4b\u540e\u901a\u8fc7CYP\u5bb6\u65cf\u540c\u5de5\u9176\u8fdb\u884c\u4ee3\u8c22\u3002\u7814\u7a76\u53d1\u73b0CYP2C8\u7684\u9057\u4f20\u591a\u6001\u6027\u4e0e\u745e\u683c\u5217\u5948\u7684\u8840\u6d46\u6d53\u5ea6\u964d\u4f4e\u6709\u5173\uff0c\u6b64\u5916\uff0c\u745e\u683c\u5217\u5948\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u4e5f\u88ab\u8bc1\u660e\u53d7SLCO1B1\u57fa\u56e0\u53d8\u5f02\u7684\u8c03\u63a7\u3002\u53e6\u6709\u7814\u7a76\u8bc4\u4f30\u4e86\u4e0e2\u578b\u7cd6\u5c3f\u75c5\u98ce\u9669\u76f8\u5173\u7684\u57fa\u56e0\u53d8\u5f02\u5bf9\u7f8e\u683c\u5217\u5948\u7684\u53cd\u5e94\u7684\u5f71\u54cd\uff0c\u5176\u4e2d\u5305\u62ecKCNQ1\u3001SLC30A8\u3001TCF7L2\u548cKCNJ11\u7684\u5355\u6838\u82f7\u9178\u591a\u6001\u6027\u3002\u4f46\u8fd9\u4e9b\u7814\u7a76\u4ec5\u5728\u4e2d\u56fd2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4e2d\u8fdb\u884c\uff0c\u6837\u672c\u91cf\u5c0f\u3002<\/span><\/p>\n

SGLT2\u6291\u5236\u5242<\/span><\/strong><\/span><\/p>\n

\u94a0\u4f9d\u8d56\u8461\u8404\u7cd6\u8f6c\u8fd0\u86cb\u767d2\uff08SGLT2\uff09\u4e3b\u8981\u4e8e\u80be\u810f\u8868\u8fbe\uff0c\u8d1f\u8d23\u80be90%\u7684\u8461\u8404\u7cd6\u91cd\u5438\u6536\uff0c\u9009\u62e9\u6027\u963b\u65adSGLT2\u5c06\u7279\u5f02\u6027\u5730\u6291\u5236\u80be\u810f\u5bf9\u8461\u8404\u7cd6\u7684\u518d\u5438\u6536\uff0c\u4f7f\u591a\u4f59\u7684\u8461\u8404\u7cd6\u901a\u8fc7\u5c3f\u6392\u51fa\uff0c\u8fbe\u5230\u964d\u4f4e\u8840\u7cd6\u7684\u76ee\u7684\u3002SGLT2\u867d\u7136\u53c2\u4e0e\u5b8c\u621090%\u4ee5\u4e0a\u7684\u80be\u5c0f\u7403\u8461\u8404\u7cd6\u91cd\u5438\u6536\uff0c\u4f46\u662f\u4e34\u5e8a\u6570\u636e\u663e\u793a\uff1aSGLT2\u6291\u5236\u5242\u53ea\u80fd\u6291\u5236\u7cd6\u5c3f\u75c5\u60a3\u800530%~50%\u7684\u8461\u8404\u7cd6\u91cd\u5438\u6536\u3002\u8fd9\u53ef\u80fd\u6d89\u53ca\u5230SGLT2\u6291\u5236\u5242\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u53caSGLT2\u7684\u57fa\u56e0\u591a\u6001\u6027\u3002<\/span><\/p>\n

\u6700\u8fd1\u7684\u4e00\u9879\u7814\u7a76\u5728134\u540d\u5065\u5eb7\u548c\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u7814\u7a76\u663e\u793a\uff0c\u5361\u683c\u5217\u51c0\u7684\u4ee3\u8c22\u4e3b\u8981\u6d89\u53caUGT1A9\u548cUGT2B4 A\u4e24\u4e2a\u57fa\u56e0\u3002Hoeben\u7b49\u4ece\u2160\u3001\u2161\u548c\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u7684\u7cd6\u5c3f\u75c5\u60a3\u8005\u548c\u5065\u5eb7\u5fd7\u613f\u8005\u4e2d\u9009\u53d6\u4e861616\u4f8b\u5bf9\u5176\u670d\u7528\u5361\u683c\u5217\u51c0\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76\u53d1\u73b0\uff0cUGT1A9 M33T(*3)\u5f71\u54cd\u5361\u683c\u5217\u51c0\u7684CLR\u3002\u6b64\u5916\uff0cEnigk\u7b49\u7814\u7a76\u53d1\u73b0SGLT2\u4f4d\u70b9\u7684Tag SNP rs9934336\u4e0eOGTT\u5b9e\u9a8c\u4e2d\u5ea6\u76f8\u5173\u3002<\/span><\/p>\n

\u5f53\u524d\uff0c\u4e5f\u6709\u6587\u732e\u62a5\u9053\u809d\u6838\u56e0\u5b50HNF1\u03b1\u7ed3\u5408\u4e8eSGLT2\u7684\u542f\u52a8\u5b50\u5e8f\u5217\u4e0a\u6e38\uff0c\u90a3\u4e48\u4eba\u7fa4\u4e2d\u7684HNF1\u03b1\u57fa\u56e0\u591a\u6001\u6027\u5c06\u5f71\u54cdSGLT2\u7684\u8f6c\u5f55\u548c\u7ffb\u8bd1\u6c34\u5e73\uff0c\u4ece\u800c\u51b3\u5b9a\u5176\u836f\u7269\u7684\u6cbb\u7597\u7597\u6548\u3002\u53e6\u5916\u4e00\u4e9b\u7814\u7a76\u8868\u660e\u6fc0\u6d3b\u6838\u53d7\u4f53PPAR\u03b4\u80fd\u591f\u63d0\u9ad8\u8102\u80aa\u7ec4\u7ec7\u5206\u6ccc\u8102\u8054\u7d20\uff08Adiponectin\uff0cAdpQ\uff09\uff0cAdpQ\u6c34\u5e73\u5347\u9ad8\u53ef\u6291\u5236\u80be\u810fSGLT2\u7684\u8868\u8fbe\uff0c\u7ee7\u800c\u63d0\u9ad8SGLT2\u6291\u5236\u5242\u964d\u7cd6\u6548\u679c\uff1b\u8fd9\u610f\u5473\u7740\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u8840\u6e05AdpQ\u6c34\u5e73\u7684\u53ef\u80fd\u4f5c\u4e3aSGLT2\u6291\u5236\u5242\u9002\u7528\u4eba\u7fa4\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002<\/span><\/p>\n

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03<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

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\u8fd1\u5e74\u6765\u4e2a\u6027\u5316\u836f\u7269\u7814\u53d1\u5728\u65b0\u65f6\u4ee3\u521b\u65b0\u836f\u7269\u53d1\u5c55\u4e2d\u5df2\u6709\u6240\u5efa\u6811\u3002\u636e\u7f8e\u56fd\u4e2a\u6027\u5316\u8054\u76df\uff08PMC\uff09\u7edf\u8ba1\uff0c2014\uff5e2017\u5e74\u671f\u95f4\uff0cFDA\u6279\u51c6\u7684\u4e2a\u6027\u5316\u836f\u7269\u7684\u603b\u6570\u4e3a44\u4e2a\uff0c\u5360\u65b0\u836f\u6570\u91cf\u768428%\u3002FDA\u6279\u51c6\u7684\u4e2a\u6027\u5316\u836f\u7269\u5728\u65b0\u836f\u83b7\u6279\u4e2d\u7684\u6bd4\u4f8b\u4e5f\u6709\u6240\u4e0a\u5347\uff0c\u75312014\u5e74\u768421%\u4e0a\u5347\u52302017\u5e7434%\u3002\u80bf\u7624\u9886\u57df\u7684\u4e2a\u6027\u5316\u836f\u7269\u7814\u53d1\u6210\u679c\u6700\u4e3a\u7a81\u51fa\uff0c\u800c\u7cd6\u5c3f\u75c5\u9886\u57df\u6682\u65e0\u4e2a\u6027\u5316\u836f\u7269\u83b7\u6279\u3002\u7cd6\u5c3f\u75c5\u7684\u5206\u5b50\u5206\u578b\u7814\u7a76\u3001\u7cd6\u5c3f\u75c5\u76f8\u5173\u751f\u7269\u6807\u5fd7\u7269\u4e0e\u4e2a\u6027\u5316\u9776\u6807\u7684\u7814\u7a76\u3001\u73b0\u6709\u7cd6\u5c3f\u75c5\u836f\u7269\u7684\u4e2a\u6027\u5316\u7814\u7a76\u53ca\u7cd6\u5c3f\u75c5\u4e2a\u6027\u5316\u65b0\u836f\u7684\u7814\u53d1\u4efb\u91cd\u9053\u8fdc\u3002<\/span>
<\/p>\n

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\u3010\u53c2\u8003\u8d44\u6599\u3011<\/span><\/p>\n

1. http:\/\/www.diabetesatlas.org\/\uff082019-01-18\uff09.<\/span><\/p>\n

2. GBD 2017 Causes of Death Collaborators. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017\uff0cLancet\uff0c2018\uff0c392\uff0810159\uff09\uff1a1736-1788.<\/span><\/p>\n

3. Fradkin JE\uff0cHanlon MC\uff0cRodgers GP. NIH Precision Medicine Initiative: Implications for Diabetes Research [J]. Diabetes Care, 2016, 39(7): 1080\u20131084.<\/span><\/p>\n

4. Merino J\uff0cFlorez JC. Precision medicine in diabetes: an opportunity for clinical translation. Ann N Y Acad Sci. 2018\uff0c1411\uff081\uff09\uff1a140-152.<\/span><\/p>\n

5. Mannino GC\uff0cAndreozzi F\uff0cSesti G. Pharmacogenetics of type 2 diabetes mellitus, the route toward tailored medicine. Diabetes Metab Res Rev\uff0c2018\uff0ce3109.<\/span><\/p>\n

6. Srinivasan S\uff0cYee SW\uff0cGiacomini KM. Pharmacogenetics of Antidiabetic Drugs. Adv Pharmacol\uff0c2018\uff0c83\uff1a361-389.<\/span><\/p>\n

7. Florez JC. Pharmacogenetics in type 2 diabetes: Precision medicine or discovery tool? Diabetologia\uff0c2017\uff0c60\uff085\uff09\uff1a800-807.<\/span><\/p>\n

8. Zhou K\uff0cYee SW\uff0cSeiser\uff0cet al. Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin. Nat Genet\uff0c2016\uff0c48\uff089\uff09\uff1a1055-1059.<\/span><\/p>\n

9. Dawed AY\uff0cZhou K\uff0cPearson ER. Pharmacogenetics in type 2 diabetes: influence on response to oral hypoglycemic agents\uff0cPharmgenomics Pers Med\uff0c2016\uff0c9\uff1a17-29.<\/span><\/p>\n

10.\u5c39\u5f71,\u674e\u854a,\u674e\u6653\u9ece\u7b49.\u6297\u7cd6\u5c3f\u75c5\u836f\u7269\u57fa\u56e0\u7ec4\u5b66\u7684\u7814\u7a76\u8fdb\u5c55,\u4e2d\u56fd\u533b\u9662\u836f\u5b66\u6742\u5fd7, 2018, 38(24): 2607-2611.<\/span><\/p>\n

11. Zhao D\uff0cZhao S\uff0cWang X\uff0cet al. Clinical and Physiological Characterization of Elevated Plasma Glucagon-Like Peptide-1 Levels\uff08Hyperglipemia\uff09in a Dipeptidyl Peptidase IV Mutation Carrier\uff0cFront Endocrinol (Lausanne)\uff0c2018\uff0c9\uff1a62.<\/span><\/p>\n

12.http:\/\/www.personalizedmedicinecoalition.org\/Resources\/The_Personalized_Medicine_Report_An_Annual_Overview_of_the_Field.<\/span><\/p>\n

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\u7248\u6743\u58f0\u660e<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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