{"id":78297,"date":"2019-01-18T00:00:50","date_gmt":"2019-02-01T06:15:41","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/78297\/"},"modified":"2019-02-01T14:15:44","modified_gmt":"2019-02-01T06:15:44","slug":"2914f48933","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/78297\/","title":{"rendered":"\u6162\u6027\u80be\u75c5\u4e2a\u6027\u5316\u836f\u7269\u76f8\u5173\u7814\u7a76\u8fdb\u5c55"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"text-indent: 2em;\"><span style=\"color: rgb(61, 167, 66);\"><strong><span style=\"font-size: 15px;\">\u75be\u75c5\u6982\u51b5<\/span><\/strong><\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u4f5c\u4e3a\u5168\u7403\u6027\u6d41\u884c\u75c5\u7684\u6162\u6027\u80be\u75c5\uff08Chronic kidney disease\uff0cCKD\uff09\u662f\u5404\u79cd\u539f\u56e0\u5f15\u8d77\u7684\u6162\u6027\u80be\u810f\u7ed3\u6784\u548c\u529f\u80fd\u969c\u788d\u3002\u5168\u7403CKD\u7684\u60a3\u75c5\u7387\u4f30\u8ba1\u572811%\uff5e13%\u4e4b\u95f4\uff08Datamonitor\u6570\u636e\u5e93\uff0c\u68c0\u7d22\u65e5\u671f\uff1a2019\u5e741\u670815\u65e5\uff09\uff0c\u6b7b\u4ea1\u7387\u4e3a1.5%\uff0c\u5728\u5168\u7403\u4e3b\u8981\u6b7b\u4ea1\u539f\u56e0\u4e2d\u4f4d\u5217\u7b2c14\uff08\u6570\u636e\u6765\u6e90\uff1a\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u5168\u7403\u5065\u5eb7\u4f30\u8ba1\uff0c\u5e74\u4efd\uff1a2012\u5e74\uff09\u3002\u800c\u5168\u7403\u75be\u75c5\u8d1f\u62c5\u7814\u7a76\u663e\u793a\uff0c2015\u5e74\u5168\u7403\u56e0CKD\u6b7b\u4ea1\u7684\u4eba\u6570\u8fbe\u5230\u4e86120\u4e07\u4eba\u3002\u5728\u6211\u56fd\uff0c\u636e2018\u5e74\u53d1\u5e03\u7684\u300a\u4e2d\u56fd\u5fc3\u8840\u7ba1\u75c5\u62a5\u544a2017\u300b\u663e\u793a\uff0cCKD\u7684\u603b\u60a3\u75c5\u7387\u4e3a10.8%\uff0c\u63a8\u7b97\u4e2d\u56fd\u6709CKD\u60a3\u8005\u8fd11.2\u4ebf\uff0c\u4f46\u77e5\u6653\u7387\u4ec5\u4e3a12.5%\u3002\u540c\u65f6\uff0cCKD\u7684\u6cbb\u7597\u8d39\u7528\u5341\u5206\u6602\u8d35\u3002\u7f8e\u56fd2015\u5e74\u533b\u7597\u4fdd\u9669\u7cfb\u7edf\u4e2d\u7528\u4e8e\u6cbb\u7597CKD\u7684\u8d39\u7528\u8d85\u8fc7\u4e86640\u4ebf\u7f8e\u5143\u3002\u5728\u4e2d\u56fd\uff0c\u636e2017\u5e74\u4e2d\u56fdCKD\u76d1\u6d4b\u6570\u636e\u7cfb\u7edf\u2014\u2014\u4e2d\u56fd\u80be\u810f\u75c5\u7f51\u7edc\uff08CK-NET\uff09\u53d1\u5e03\u7684\u9996\u4e2a\u5e74\u5ea6\u62a5\u544a\uff08CK-NET 2014\u5e74\u5ea6\u62a5\u544a\uff09\u663e\u793a\uff0cCKD\u60a3\u8005\u7684\u4e2d\u4f4d\u8d39\u7528\u4e3a9500\u5143\uff0c\u4e14\u5728\u8d39\u7528\u7c7b\u522b\u65b9\u9762\u4e3b\u8981\u96c6\u4e2d\u4e8e\u897f\u836f\uff0835.2%\uff09\u548c\u8bca\u65ad\uff08\u4e0d\u523020%\uff09\uff08\u56fe1\uff09\u3002\u800c\u6839\u636e\u536b\u751f\u90e82012\u5e74\u300a\u4e2d\u56fd\u536b\u751f\u53d1\u5c55\u7eff\u76ae\u4e66\u300b\u7684\u6570\u636e\uff0c\u6bcf\u4e2a\u8840\u900f\u60a3\u8005\u7684\u5e74\u5747\u76f4\u63a5\u6cbb\u7597\u8d39\u7528\u4e3a75085.92\u5143\u3002<\/span><\/p>\n<p style=\"text-align: center;text-indent: 0em;\"><img loading=\"lazy\" align=\"\" class=\"\"     height=\"259\" title=\"\u6162\u6027\u80be\u75c5\u4e2a\u6027\u5316\u836f\u7269\u76f8\u5173\u7814\u7a76\u8fdb\u5c55\" width=\"650\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/10-1549001741.jpg\" alt=\"\u6162\u6027\u80be\u75c5\u4e2a\u6027\u5316\u836f\u7269\u76f8\u5173\u7814\u7a76\u8fdb\u5c55\"  \/> <\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u9274\u4e8eCKD\u7684\u4e25\u91cd\u6027\uff0c\u65e9\u57282006\u5e74\uff0c\u56fd\u9645\u80be\u810f\u75c5\u5b66\u4f1a\uff08International Society of Nephrology\uff0cISN\uff09\u548c\u56fd\u9645\u80be\u810f\u57fa\u91d1\u8054\u5408\u4f1a\uff08International Federation of Kidney Foundation\uff0cIFKF\uff09\u8054\u5408\u5021\u8bae\uff0c\u5c06\u6bcf\u5e743\u6708\u4efd\u7684\u7b2c2\u4e2a\u661f\u671f\u56db\u5b9a\u4e3a\u201c\u4e16\u754c\u80be\u810f\u65e5\u201d\uff0c\u76ee\u7684\u662f\u5524\u8d77\u5168\u7403\u5404\u754c\u4eba\u58eb\u5bf9CKD\u7684\u9ad8\u5ea6\u5173\u6ce8\u3002\u540c\u65f6\uff0c\u4f20\u7edf\u7684\u8bca\u65ad\u4f53\u7cfb\u4ec5\u5c40\u9650\u5728\u80be\u810f\u75c5\u7406\u53ca\u4e34\u5e8a\u8868\u73b0\uff0c\u800c\u7cbe\u51c6\u533b\u5b66\u5728\u5206\u5b50\u751f\u7269\u5b66\u57fa\u7840\u4e0a\u8bca\u65ad\u5b9a\u4f4d\u5e76\u5236\u8ba2\u4e2a\u4f53\u5316\u6cbb\u7597\u65b9\u6848\uff0c\u53ef\u4e3a\u80be\u810f\u75be\u75c5\u7684\u8bca\u7597\u63d0\u4f9b\u65b0\u7684\u601d\u8def\uff0c\u5176\u4e2d\uff0cCKD\u7cbe\u51c6\u533b\u5b66\u7684\u6a21\u5f0f\u53ef\u5982\u56fe2\u6240\u793a\uff0c\u5176\u6d89\u53ca\u4e2a\u4f53\u60a3\u8005\u6570\u636e\u4e91\u3001\u7cfb\u7edf\u751f\u7269\u5b66\u3001\u9884\u6d4b\u5efa\u6a21\u3001\u57fa\u7840\u548c\u5e94\u7528\u7814\u7a76\u7b49\uff0c\u4ee5\u7cbe\u786e\u8bca\u65ad\u548c\u91cf\u8eab\u5b9a\u5236\u8fdb\u884c\u5e72\u9884\u3002<\/span><\/p>\n<p style=\"text-align: center;text-indent: 0em;\"><img loading=\"lazy\" align=\"\" class=\"\"     height=\"425\" title=\"\u6162\u6027\u80be\u75c5\u4e2a\u6027\u5316\u836f\u7269\u76f8\u5173\u7814\u7a76\u8fdb\u5c55\" width=\"550\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/3-1549001742.jpg\" alt=\"\u6162\u6027\u80be\u75c5\u4e2a\u6027\u5316\u836f\u7269\u76f8\u5173\u7814\u7a76\u8fdb\u5c55\"  \/> <\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;color: rgb(61, 167, 66);\"><strong>\u76f8\u5173\u57fa\u56e0\u7814\u7a76<\/strong><\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">CKD\u60a3\u8005\u5728\u9ad8\u4e8e65\u5c81\u7684\u4eba\u7fa4\u4e2d\u6700\u4e3a\u5e38\u89c1\uff0c\u7136\u800c\uff0c\u5e74\u8f7b\u4eba\u7fa4\uff08\u226465\u5c81\uff09\u8fdb\u5c55\u4e3a\u7ec8\u672b\u671f\u80be\u75c5\uff08ESRD\uff09\u7684\u98ce\u9669\u66f4\u9ad8\u3002\u5176\u4e2d\uff0cCKD\u53d1\u75c5\u7684\u98ce\u9669\u56e0\u7d20\u5982\u88681\u6240\u793a\uff0c\u4f46\u4e3b\u8981\u56e0\u7d20\u662f\u9ad8\u8840\u538b\u548c\u7cd6\u5c3f\u75c5\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5355\u57fa\u56e0\u80be\u75c5\u7684\u4f8b\u5b50\u6709\u5e38\u67d3\u8272\u4f53\u663e\u6027\u9057\u4f20\u6027\u591a\u56ca\u80be\u75c5\u3001\u5f15\u8d77\u7c7b\u56fa\u9187\u6297\u6027\u80be\u75c5\u7efc\u5408\u5f81\u7684\u8db3\u7ec6\u80de\u75c5\u3001Fabry\u75c5\u3001Alport\u7efc\u5408\u5f81\u548c\u8865\u4f53\u75c5\uff08\u5982\u975e\u5178\u578b\u6eb6\u8840\u6027\u5c3f\u6bd2\u75c7\u7efc\u5408\u5f81\uff09\u3002\u5176\u4e2d\uff0cFabry\u662f\u4e00\u79cdX\u8fde\u9501\u7684\u663e\u6027\u9057\u4f20\u6027\u6eb6\u9176\u4f53\u8d2e\u79ef\u75c7\uff0c\u662f\u7531\u4e8eGLA\u57fa\u56e0\u7a81\u53d8\u5bfc\u81f4\u03b1-\u534a\u4e73\u7cd6\u82f7\u9176A\uff08\u03b1-Gal A\uff09\u7f3a\u9677\u6240\u81f4\uff0c\u4f1a\u5bfc\u81f4\u80be\u8870\u7aed\u3001\u5fc3\u810f\u75c5\u3001\u75bc\u75db\u7b49\u4e00\u7cfb\u5217\u95ee\u9898\u3002<\/span><\/p>\n<p style=\"text-align: center;text-indent: 0em;\"><img loading=\"lazy\" align=\"\" class=\"\"     height=\"460\" title=\"\u6162\u6027\u80be\u75c5\u4e2a\u6027\u5316\u836f\u7269\u76f8\u5173\u7814\u7a76\u8fdb\u5c55\" width=\"450\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/10-1549001742.jpg\" alt=\"\u6162\u6027\u80be\u75c5\u4e2a\u6027\u5316\u836f\u7269\u76f8\u5173\u7814\u7a76\u8fdb\u5c55\"  \/> <\/p>\n<p style=\"text-align: center;text-indent: 2em;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">*\uff1a\u4e5f\u662f\u5f71\u54cdCKD\u8fdb\u5c55\u7684\u98ce\u9669\u56e0\u7d20<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u80be\u7ea4\u7ef4\u5316\u662fCKD\u7684\u5e38\u89c1\u75c5\u7406\u8fc7\u7a0b\uff0c\u5176\u4f1a\u5bfc\u81f4\u7ec8\u672b\u671f\u80be\u75c5\u3002\u76ee\u524d\uff0c\u4e0e\u80be\u7ea4\u7ef4\u5316\u76f8\u5173\u7684\u57fa\u56e0\u7ec4\u5b66\u7684\u4e3b\u8981\u53d1\u73b0\u5982\u88682\u6240\u793a\uff0c\u5176\u4e2d\uff0cTGF-\u03b21\uff08Transforming growth factor-\u03b21\uff09\u5728\u80be\u7ea4\u7ef4\u5316\u4e2d\u7684\u6f5c\u5728\u9776\u5411\u5e72\u9884\u5982\u56fe3\u6240\u793a\uff0c\u5176\u6d89\u53ca\u591a\u79cd\u901a\u8def\u3002<\/span><\/p>\n<p style=\"text-align: center;text-indent: 0em;\"><img loading=\"lazy\" align=\"\" class=\"\"     height=\"245\" title=\"\u6162\u6027\u80be\u75c5\u4e2a\u6027\u5316\u836f\u7269\u76f8\u5173\u7814\u7a76\u8fdb\u5c55\" width=\"500\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/8-1549001743.jpg\" alt=\"\u6162\u6027\u80be\u75c5\u4e2a\u6027\u5316\u836f\u7269\u76f8\u5173\u7814\u7a76\u8fdb\u5c55\"  \/> <\/p>\n<p style=\"text-align: center;text-indent: 0em;\"><img loading=\"lazy\" align=\"\" class=\"\"     height=\"589\" title=\"\u6162\u6027\u80be\u75c5\u4e2a\u6027\u5316\u836f\u7269\u76f8\u5173\u7814\u7a76\u8fdb\u5c55\" width=\"650\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/4-1549001743.jpg\" alt=\"\u6162\u6027\u80be\u75c5\u4e2a\u6027\u5316\u836f\u7269\u76f8\u5173\u7814\u7a76\u8fdb\u5c55\"  \/> <\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u800c\u5728\u4e0eCKD\u98ce\u9669\u76f8\u5173\u7684\u57fa\u56e0\u7814\u7a76\u65b9\u9762\uff0c2018\u5e7411\u6708\uff0c\u82f1\u56fd\u66fc\u5f7b\u65af\u7279\u5927\u5b66\u79d1\u5b66\u5bb6\u9886\u5bfc\u7684\u7814\u7a76\u56e2\u961f\u5728\u300aNature Communications\u300b\u6742\u5fd7\u4e0a\u53d1\u8868\u4e86\u9898\u4e3a\u201cMolecular insights into genome-wide association studies of chronic kidney disease-defining traits\u201d\u7684\u6587\u7ae0\u3002\u8be5\u6587\u62a5\u9053\u4e86\u901a\u8fc7\u5f00\u5c55\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff08GWAS\uff09\uff0c\u786e\u5b9a\u4e8635\u4e2a\u4e0eCKD\u98ce\u9669\u76f8\u5173\u7684\u57fa\u56e0\uff08\u88683\uff09\uff0c\u5176\u4e2d\uff0cRP11-10L12.4\u3001HLA-DQB1-AS1\u548cCTD-2651B20.3\u8fd93\u4e2a\u57fa\u56e0\u5c5e\u4e8e\u957f\u975e\u7f16\u7801\u57fa\u56e0\uff08long non-coding\uff09\uff0cGBAP1\u3001HLA-DRB6\u3001HLA-K\u548cHCG4B\u8fd94\u4e2a\u57fa\u56e0\u5c5e\u4e8e\u5047\u57fa\u56e0\uff08pseudogene\uff09\uff0c\u5176\u4f5928\u4e2a\u57fa\u56e0\u5c5e\u4e8e\u7f16\u7801\u86cb\u767d\u7684\u57fa\u56e0\u3002\u540c\u65f6\uff0cMUC1\uff08Mucin 1\uff0ccell surface associated\uff09\u57fa\u56e0\u4f1a\u5bfc\u81f4\u4e00\u79cd\u7f55\u89c1\u7684\u7b26\u5408\u5b5f\u5fb7\u5c14\u9057\u4f20\u89c4\u5f8b\u7684\u80be\u810f\u75be\u75c5\u3002\u8fd9\u9879\u7814\u7a76\u6709\u671b\u50ac\u751f\u66f4\u597d\u7684CKD\u8bca\u65ad\u548c\u6cbb\u7597\u65b9\u6cd5\u3002<\/span><\/p>\n<p style=\"text-align: center;text-indent: 0em;\"><img loading=\"lazy\" align=\"\" class=\"\"     height=\"626\" title=\"\u6162\u6027\u80be\u75c5\u4e2a\u6027\u5316\u836f\u7269\u76f8\u5173\u7814\u7a76\u8fdb\u5c55\" width=\"450\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/7-1549001744.jpg\" alt=\"\u6162\u6027\u80be\u75c5\u4e2a\u6027\u5316\u836f\u7269\u76f8\u5173\u7814\u7a76\u8fdb\u5c55\"  \/> <\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u540c\u65f6\uff0c\u8fd1\u5e74\u6765\uff0cAPOL1\u57fa\u56e0\uff08APOL1\uff09\u9010\u6e10\u88ab\u7eb3\u5165\u9ad8\u8840\u538b\u80be\u75c5\u9057\u4f20\u5b66\u7814\u7a76\u5e76\u8fc5\u901f\u6210\u4e3a\u70ed\u70b9\u3002APOL1\u4f4d\u4e8e\u67d3\u8272\u4f5322q12.3-13.1\u533a\u57df\uff0c\u5168\u957f14461bp\u3002\u4e0e\u5176\u4ed6\u56e0\u65e0\u4fe1\u53f7\u80bd\u800c\u5b9a\u4f4d\u4e8e\u7ec6\u80de\u5185\u7684APOL\u86cb\u767d\u4e0d\u540c\uff0cAPOL1\u86cb\u767d\u662f\u552f\u4e00\u5177N\u7aef\u4fe1\u53f7\u80bd\u800c\u5206\u6ccc\u81f3\u7ec6\u80de\u5916\u7684APOL\u86cb\u767d\uff0c\u4e0eAPOA\u86cb\u767d\u7ed3\u5408\u5b58\u5728\u4e8e\u8840\u6d46\u7684\u9ad8\u5bc6\u5ea6\u8102\u86cb\u767d\u9897\u7c92\u3002\u7814\u7a76\u53d1\u73b0\uff0cAPOL1\u53d8\u5f02\u4e0e\u539f\u53d1\u6027\u9ad8\u8840\u538b\u6240\u81f4CKD\u6709\u5f88\u5f3a\u7684\u76f8\u5173\u6027\uff0c\u4e14\u9ad8\u8840\u538b\u6cbb\u7597\u4e0d\u80fd\u963b\u6b62\u80be\u810f\u75be\u75c5\u7684\u8fdb\u5c55\uff1b\u9ad8\u8840\u538b\u5bfc\u81f4\u7684CKD\u60a3\u8005\u4e2d\uff0c\u5b58\u5728APOL1\u9ad8\u5371\u57fa\u56e0\u578b\uff08\u6709\u4e24\u4e2aG1\u6216G2\u98ce\u9669\u7b49\u4f4d\u57fa\u56e0\uff09\u7684\u80be\u5c0f\u7403\u6ee4\u8fc7\u7387\u4f30\u503c\uff08eGFR\uff09\u4e0b\u964d\u66f4\u4e3a\u660e\u663e\u3002\u53e6\u4e00\u65b9\u9762\uff0cMYH9\u53d8\u5f02\u4e0e\u80be\u75c5\u7684\u76f8\u5173\u7814\u7a76\u4e5f\u662f\u8fd1\u5e74\u7684\u7814\u7a76\u70ed\u70b9\u3002MYH9\u4f4d\u4e8e\u67d3\u8272\u4f5322q12.3-13.1\u533a\u57df\uff0c\u5168\u957f139kb\u3002MYH9\u7a81\u53d8\u5f15\u8d77\u7684\u5f02\u5e38\u8868\u8fbe\u3001\u5b9a\u4f4d\u6216\u529f\u80fd\u6539\u53d8\u90fd\u4f1a\u5bfc\u81f4\u808c\u7403\u86cb\u767d\u5f02\u5e38\uff0c\u4f7f\u8db3\u7ec6\u80de\u548c\u80be\u5c0f\u7ba1\u7684\u7ec6\u80de\u9aa8\u67b6\u53d7\u635f\uff0c\u5f15\u8d77\u5c40\u90e8\u80be\u5c0f\u7403\u8db3\u7a81\u878d\u5408\uff0c\u8db3\u7ec6\u80de\u88c2\u5b54\u819c\u6d88\u5931\u8fdb\u800c\u635f\u4f24\u80be\u810f\uff0c\u8fdb\u4e00\u6b65\u5bfc\u81f4\u86cb\u767d\u5c3f\u3001\u8840\u5c3f\u751a\u81f3\u80be\u8870\u7aed\u3002\u7814\u7a76\u53d1\u73b0\uff0cMYH9\u53d8\u5f02\u4e0eCKD\u76f8\u5173\uff0c\u5e76\u52a0\u5feb\u7ec8\u672b\u671f\u80be\u75c5\uff08ESRD\uff09\u8fdb\u5c55\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;color: rgb(61, 167, 66);\"><strong>\u9057\u4f20\u56e0\u7d20\u65b9\u9762\u7684\u6cbb\u7597\u5e72\u9884<\/strong><\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">CKD\u5177\u6709\u60a3\u75c5\u7387\u9ad8\u3001\u75c5\u56e0\u590d\u6742\u3001\u6cbb\u7597\u56f0\u96be\u7b49\u7279\u70b9\uff0c\u56e0\u800c\uff0c\u6025\u9700\u5728\u75be\u75c5\u9884\u9632\u548c\u65e9\u671f\u53d1\u73b0\u3001\u5e72\u9884\u548c\u66ff\u4ee3\u6cbb\u7597\u7b49\u65b9\u9762\u53d6\u5f97\u7a81\u7834\u3002CKD\u9632\u6cbb\u7684\u4e00\u4e2a\u5173\u952e\u73af\u8282\u662f\u963b\u6b62\u6216\u5ef6\u7f13CKD\u8fdb\u5c55\u3002\u80be\u5355\u4f4d\u635f\u4f24\u53ef\u7531\u591a\u79cd\u89e6\u53d1\u56e0\u7d20\u9a71\u52a8\uff0c\u800c\u5e9f\u9664\u8fd9\u4e9b\u89e6\u53d1\u56e0\u7d20\u4f1a\u51cf\u7f13CKD\u548cESRD\u7684\u8fdb\u5c55\uff0c\u5176\u4e2d\uff0c\u56e0\u9057\u4f20\u56e0\u7d20\u5bfc\u81f4CKD\u7684\u6cbb\u7597\u6027\u5e72\u9884\u5982\u88684\u6240\u793a\uff0c\u5982\u6d89\u53ca\u591a\u56ca\u6027\u80be\u75c5\u3001Alport\u7efc\u5408\u5f81\u3001Fabry\u75c5\u3001\u539f\u53d1\u6027\u9ad8\u8349\u9178\u5c3f\u75c7\u3001\u80f1\u6c28\u9178\u75c5\u3001\u8f85\u9176Q10-\u76f8\u5173\u57fa\u56e0\u7a81\u53d8\u5bfc\u81f4\u7684FSGS\uff08Focal segmental glomerulosclerosis\uff09\u4ee5\u53caC3\uff08Complement 3\uff09\u80be\u5c0f\u7403\u6027\u80be\u708e\u8fd9\u4e9b\u75c5\u7684\u6cbb\u7597\u5e72\u9884\u63aa\u65bd\u3002<\/span><\/p>\n<p style=\"text-align: center;text-indent: 0em;\"><img loading=\"lazy\" align=\"\" class=\"\"     height=\"366\" title=\"\u6162\u6027\u80be\u75c5\u4e2a\u6027\u5316\u836f\u7269\u76f8\u5173\u7814\u7a76\u8fdb\u5c55\" width=\"700\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/2-1549001744.jpg\" alt=\"\u6162\u6027\u80be\u75c5\u4e2a\u6027\u5316\u836f\u7269\u76f8\u5173\u7814\u7a76\u8fdb\u5c55\"  \/> <\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;color: rgb(61, 167, 66);\"><strong>2018\u5e74FDA\u65b0\u6279\u836f\u7269Galafold<\/strong><\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">Amicus Therapeutics\u516c\u53f8\u7684Galafold\uff08Migalastat\uff0c\u56fe4\uff09\u4e8e2018\u5e748\u6708\u83b7\u7f8e\u56fdFDA\u6279\u51c6\uff0c\u7528\u4e8e\u4f53\u5916\u68c0\u6d4b\u8bc1\u5b9e\u5b58\u5728\u7279\u5b9a\u03b1-\u534a\u4e73\u7cd6\u82f7\u9176\u57fa\u56e0\u7a81\u53d8\u7684Fabry\u75c5\u6210\u4eba\u60a3\u8005\u7684\u6cbb\u7597\u3002FDA\u5df2\u6279\u51c6Galafold\u7528\u4e8e\u6cbb\u7597\u591a\u8fbe348\u79cdGLA\u7a81\u53d8\u7684Fabry\u75c5\u3002\u636e\u4f30\u8ba1\uff0c\u5728\u7f8e\u56fd\u5927\u7ea6\u67093000\u4f8bFabry\u75c5\u60a3\u8005\uff0c\u5176\u4e2d\u5927\u7ea650%\u53ef\u63a5\u53d7Galafold\u6cbb\u7597\u3002\u6b64\u6b21\u6279\u51c6\uff0c\u4f7fGalafold\u6210\u4e3a\u7f8e\u56fd\u5e02\u573a\u6cbb\u7597\u6cd5\u5e03\u91cc\u75c5\u7684\u9996\u4e2a\u53e3\u670d\u836f\u7269\uff0c\u540c\u65f6\u4e5f\u662f\u8fc7\u53bb15\u5e74\u6765\u83b7\u7f8e\u56fdFDA\u6279\u51c6\u7684\u9996\u4e2aFabry\u75c5\u521b\u65b0\u7597\u6cd5\u3002<\/span><\/p>\n<p style=\"text-align: center;text-indent: 0em;\">\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u4e0e\u9176\u66ff\u4ee3\u6cbb\u7597\u4e0d\u540c\u7684\u662f\uff0cGalafold\u662f\u4e00\u79cd\u03b1-\u534a\u4e73\u7cd6\u82f7\u9176A\uff08\u03b1-Gal A\uff09\u7684\u53e3\u670d\u836f\u7406\u5b66\u201c\u5206\u5b50\u4f34\u4fa3\u201d\uff0c\u80fd\u9009\u62e9\u6027\u3001\u53ef\u9006\u6027\u5730\u7ed3\u5408\u7279\u5b9a\u7a81\u53d8\u7c7b\u578b\u7684\u03b1-Gal A\u9176\uff0c\u7a33\u5b9a\u8fd9\u4e9b\u529f\u80fd\u5931\u8c03\u7684\u9176\uff0c\u4ece\u800c\u53d1\u6325\u6cbb\u7597\u4f5c\u7528\u3002\u5728\u5168\u7403\u8303\u56f4\u5185\uff0c\u636e\u4f30\u8ba1\u5927\u7ea635%\uff5e50%\u7684\u6cd5\u5e03\u91cc\u75c5\u60a3\u8005\u5b58\u5728\u53ef\u6cbb\u7597\u7684GLA\u53d8\u4f53\u3002\u9664\u7f8e\u56fd\u5916\uff0cMigalastat\u5728\u6fb3\u5927\u5229\u4e9a\u3001\u52a0\u62ff\u5927\u3001\u6b27\u76df\u3001\u4ee5\u8272\u5217\u3001\u65e5\u672c\u3001\u97e9\u56fd\u548c\u745e\u58eb\u4e5f\u5df2\u83b7\u6279\uff0c\u76ee\u524d\u53f0\u6e7e\u5730\u533a\u83b7\u6279\u5de5\u4f5c\u6b63\u5728\u8fdb\u884c\u4e2d\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u4f5c\u4e3a\u5168\u7403\u9996\u4e2a\u53e3\u670d\u6cd5\u5e03\u91cc\u75c5\u6cbb\u7597\u836f\u7269\uff0c\u4e1a\u754c\u975e\u5e38\u770b\u597d\u8be5\u836f\u3002\u636eIMS Health Analytics Link\u6570\u636e\u5e93\uff08\u68c0\u7d22\u65e5\u671f\uff1a2019\u5e741\u67088\u65e5\uff09\u663e\u793a\uff0cGalafold\u76842016\u30012017\u7684\u5e74\u9500\u552e\u989d\u5206\u522b\u4e3a300\u4e07\u7f8e\u5143\u548c2000\u4e07\u7f8e\u5143\uff0c\u540c\u65f6\uff0c\u636eEvaluatePharma\u9884\u6d4b\uff0c\u8be5\u836f\u5c06\u57282024\u5e74\u8fbe\u52305.6\u4ebf\u7f8e\u5143\u7684\u9500\u552e\u989d\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;color: rgb(61, 167, 66);\"><strong>\u514d\u75ab\u6291\u5236\u836f\u4ed6\u514b\u83ab\u53f8\uff08Tacrolimus\uff09<\/strong><\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u76ee\u524d\u7cd6\u76ae\u8d28\u6fc0\u7d20\u662f\u6cbb\u7597\u539f\u53d1\u6027\u80be\u75c5\u7efc\u5408\u5f81\uff08INS\uff09\u7684\u4e00\u7ebf\u7528\u836f\uff0c\u4f46\u5bf9\u4e8e\u6fc0\u7d20\u4f9d\u8d56\u6216\u6fc0\u7d20\u62b5\u6297\u7684INS\u60a3\u8005\uff0c\u5219\u9700\u4f7f\u7528\u514d\u75ab\u6291\u5236\u836f\u6cbb\u7597\u3002\u65b0\u578b\u514d\u75ab\u6291\u5236\u836f\u4ed6\u514b\u83ab\u53f8\uff08Tacrolimus\uff09\u76f8\u5bf9\u4e8e\u73af\u5b62\u7d20\u548c\u5927\u5242\u91cf\u7532\u6cfc\u5c3c\u9f99\u51b2\u51fb\u6cbb\u7597\u800c\u8a00\uff0c\u611f\u67d3\u53d1\u751f\u7387\u4f4e\uff0c\u5c24\u5176\u5bf9\u4e8e\u6fc0\u7d20\u8010\u53d7\u6027\u80be\u75c5\u7efc\u5408\u5f81\u6765\u8bf4\u662f\u4e00\u79cd\u9ad8\u6548\u3001\u8010\u53d7\u6027\u826f\u597d\u7684\u514d\u75ab\u6291\u5236\u836f\u3002\u8be5\u836f\u5c5e\u4e8e\u9499\u8c03\u78f7\u9178\u9176\u6291\u5236\u5242\uff0c1984\u5e74\u9996\u6b21\u5728\u65e5\u672c\u4ece\u571f\u58e4\u771f\u83cc\u7684\u8089\u6c64\u57f9\u517b\u57fa\u4e2d\u63d0\u53d6\u51fa\u6765\uff0c1993\u5e74\u9996\u5148\u4e8e\u65e5\u672c\u4e0a\u5e02\uff0c1994\u5e74\u5728\u7f8e\u56fd\u548c\u82f1\u56fd\u7b49\u56fd\u5bb6\u4e0a\u5e02\uff0c1999\u5e74\u5728\u4e2d\u56fd\u4e0a\u5e02\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u7136\u800c\uff0c\u7ec6\u80de\u8272\u7d20P450 3A5\uff08CYP3A5\uff09\u7684\u57fa\u56e0\u591a\u6001\u6027\u5bf9\u4ed6\u514b\u83ab\u53f8\u7684\u8840\u836f\u6d53\u5ea6\u6709\u663e\u8457\u5f71\u54cd\uff0c\u4e16\u754c\u5404\u56fd\u5747\u53d1\u5e03\u4e86\u57fa\u4e8e\u836f\u7269\u57fa\u56e0\u7ec4\u5b66\u7684\u4ed6\u514b\u83ab\u53f8\u7528\u836f\u6307\u5357\u3002\u7531\u4e8e\u4ed6\u514b\u83ab\u53f8\u4f53\u5185\u8fc7\u7a0b\u4e2a\u4f53\u5dee\u5f02\u5927\uff0c\u9700\u8981\u7ed3\u5408\u57fa\u56e0\u68c0\u6d4b\u7ed3\u679c\u3001\u79cd\u65cf\u5dee\u5f02\u60c5\u51b5\u548c\u4e2a\u4f53\u5316\u4ee3\u8c22\u7279\u70b9\u5236\u5b9a\u521d\u59cb\u5242\u91cf\uff0c\u4e14\u6cbb\u7597\u7a97\uff085\uff5e10ng\u00b7mL-1\uff09\u76f8\u5bf9\u8f83\u7a84\uff0c\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u9700\u8981\u5b9a\u671f\u76d1\u6d4b\u8840\u6e05\u836f\u7269\u6d53\u5ea6\uff0c\u6839\u636e\u75c5\u60c5\u53d8\u5316\u53ca\u65f6\u8c03\u6574\u4ed6\u514b\u83ab\u53f8\u7684\u7528\u91cf\uff0c\u4ee5\u9632\u6b62\u836f\u7269\u4e0d\u826f\u53cd\u5e94\u7684\u53d1\u751f\u3002<\/span><\/p>\n<p style=\"text-indent: 28px;\"><span style=\"font-size: 15px;color: rgb(61, 167, 66);\"><strong>\u4e2d\u836f\u6cbb\u7597<\/strong><\/span><\/p>\n<p style=\"text-indent: 28px;\"><span style=\"font-size: 15px;color: rgb(62, 52, 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style=\"text-indent: 2em;\"><span style=\"font-size: 15px;color: rgb(61, 167, 66);\"><strong>\u5c0f\u7ed3<\/strong><\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">\u7531\u4e8e\u5f15\u8d77CKD\u7684\u56e0\u7d20\u662f\u591a\u79cd\u591a\u6837\u4e14\u76f8\u4e92\u5f71\u54cd\uff0c\u5bfc\u81f4\u53d1\u75c5\u673a\u5236\u6781\u5176\u590d\u6742\u3002\u800c\u968f\u7740\u57fa\u56e0\u7ec4\u5b66\u3001\u86cb\u767d\u7ec4\u5b66\u3001\u4ee3\u8c22\u7ec4\u5b66\u548c\u836f\u7269\u57fa\u56e0\u7ec4\u5b66\u7b49\u7684\u6df1\u5165\u7814\u7a76\uff0c\u4e3aCKD\u7684\u4e2a\u6027\u5316\u6cbb\u7597\u63d0\u4f9b\u65b0\u601d\u8def\u3002\u4f8b\u5982\uff0c2018\u5e749\u6708\u6fb3\u5927\u5229\u4e9a\u548c\u7f8e\u56fd\u7684\u7814\u7a76\u4eba\u5458\u5728\u300a\u7ec6\u80de\u300b\u6742\u5fd7\u4e0a\u53d1\u8868\u6587\u7ae0\u79f0\uff0c\u4ed6\u4eec\u5728\u5c0f\u9f20\u4f53\u5185\u53d1\u73b0\u4e00\u79cd\u548c\u80be\u75c5\u76f8\u5173\u7684\u5168\u65b0\u75c5\u6bd2\uff0c\u6709\u671b\u4e3a\u6cbb\u7597CKD\u548c\u513f\u7ae5\u9057\u4f20\u6027\u80be\u75c5\u63d0\u4f9b\u65b0\u624b\u6bb5\uff1b2018\u5e748\u6708\uff0c\u65e5\u672c\u718a\u672c\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u5229\u7528\u6e90iPS\u7ec6\u80de\u8bf1\u5bfc\u80be\u810f\u7ec4\u7ec7\u518d\u73b0\u4e86\u75be\u75c5\u72b6\u6001\uff0c\u8fd9\u662f\u9996\u4e2a\u5229\u7528\u60a3\u8005\u7684iPS\u7ec6\u80de\u518d\u73b0\u80be\u5c0f\u7403\u6027\u80be\u75c5\u75c5\u72b6\u7684\u6210\u529f\u6848\u4f8b\uff0c\u6709\u52a9\u4e8e\u67e5\u660e\u75c5\u56e0\u548c\u5f00\u53d1\u65b0\u836f\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"color: rgb(0, 82, 255);\"><strong><span style=\"color:#3e3434;\"><span style=\"font-size: 15px;\">\u9700\u8981\u66f4\u591a\u6162\u6027\u80be\u75c5\u76f8\u5173\u62a5\u544a\uff0c\u8bf7\u8054\u7cfb\u6211\u4eec~<\/span><\/span><\/strong><\/span><\/p>\n<p style=\"margin-bottom: 5px;margin-top: 5px;line-height: normal;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">\u53c2\u8003\u8d44\u6599<\/span><\/p>\n<p style=\"margin-bottom: 5px;margin-top: 5px;line-height: normal;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">1. Zhang L, Wang H, Long J, et al. China Kidney Disease Network (CK-NET) 2014 Annual Data Report. American Journal of Kidney Diseases, 2017, 69(6)(suppl 2): S1-S149.<\/span><\/p>\n<p style=\"margin-bottom: 5px;margin-top: 5px;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 12px;\">2. Romagnani P, Remuzzi G, Glassock R, et al. Chronic kidney disease. Nature Reviews Disease Primers, 2017, 3: 17088.<\/span><\/p>\n<p style=\"margin-bottom: 5px;margin-top: 5px;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 12px;\">3. Xu X, Eales JM, Akbarov A, et al. Molecular insights into genome-wide association studies of chronic kidney disease-defining traits. Nature Communications, 2018, 9(1): 4800.<\/span><\/p>\n<p style=\"margin-bottom: 5px;margin-top: 5px;line-height: normal;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">4. Sun L, Zou LX, Chen MJ. Make Precision Medicine Work for Chronic Kidney Disease. Medical Principles and Pratice, 2017, 26: 101-107.<\/span><\/p>\n<p style=\"margin-bottom: 5px;margin-top: 5px;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 12px;\">5. \u5f20\u6653\u4e39, \u89e3\u67d3, \u5d14\u4e00\u6c11. \u80be\u75c5\u7efc\u5408\u5f81\u60a3\u8005\u4e2a\u4f53\u5316\u5e94\u7528\u4ed6\u514b\u83ab\u53f8\u7684\u75c5\u4f8b\u5206\u6790. \u4e2d\u56fd\u4e34\u5e8a\u836f\u7406\u5b66\u6742\u5fd7, 2018, 34(19): 2345-2347.<\/span><\/p>\n<p style=\"margin-bottom: 5px;margin-top: 5px;line-height: normal;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">6. \u4e2d\u534e\u533b\u5b66\u4f1a\u5668\u5b98\u79fb\u690d\u5b66\u5206\u4f1a. \u4ed6\u514b\u83ab\u53f8\u5728\u4e34\u5e8a\u809d\u79fb\u690d\u4e2d\u7684\u5e94\u7528\u6307\u5357. \u4e34\u5e8a\u809d\u80c6\u75c5\u6742\u5fd7, 31(9): 1372-1374.<\/span><\/p>\n<p style=\"margin-bottom: 5px;margin-top: 5px;line-height: normal;\"><span style=\"color: rgb(136, 136, 136);font-size: 12px;\">7. \u5f20\u6676, \u5f20\u627f\u82f1, \u5f20\u5efa\u8363. \u7cbe\u51c6\u533b\u5b66\u5728\u80be\u810f\u75c5\u5b66\u4e2d\u7684\u5e94\u7528. \u533b\u5b66\u7efc\u8ff0, 2018, 24(19): 3873-3882.<\/span><\/p>\n<p style=\"margin-bottom: 5px;margin-top: 5px;line-height: normal;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">8. \u9648\u9f99, \u5c91\u4e1c. APOL1\u57fa\u56e0\u53d8\u5f02\u4e0e\u9ad8\u8840\u538b\u80be\u75c5\u5173\u8054\u7684\u7814\u7a76\u8fdb\u5c55. \u73b0\u4ee3\u5b9e\u7528\u533b\u5b66, 2018, 30(9): 1257-1259.<\/span><\/p>\n<p style=\"margin-bottom: 5px;margin-top: 5px;line-height: normal;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">9. \u6797\u7f8e\u68e3, \u5b59\u4f1f. \u5065\u813e\u76ca\u80be\u6cd5\u6cbb\u7597\u6162\u6027\u80be\u75c5\u7814\u7a76\u73b0\u72b6. \u56fd\u533b\u8bba\u575b, 2018, 33(2): 65.<\/span><\/p>\n<p style=\"margin-bottom: 5px;margin-top: 5px;line-height: normal;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">10. Datamonitor\u6570\u636e\u5e93, \u68c0\u7d22\u65e5\u671f: 2019\u5e741\u670815\u65e5.<\/span><\/p>\n<p style=\"margin-bottom: 5px;margin-top: 5px;line-height: normal;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">11. IMS Health Analytics Link\u6570\u636e\u5e93, \u68c0\u7d22\u65e5\u671f: 2019\u5e741\u67088\u65e5.<\/span><\/p>\n<p style=\"margin-bottom: 5px;margin-top: 5px;line-height: normal;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">12. http:\/\/med.sina.com\/article_detail_103_2_50558.html.<\/span><\/p>\n<p style=\"margin-bottom: 5px;margin-top: 5px;line-height: normal;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">13. http:\/\/www.ebiotrade.com\/newsf\/2018-11\/20181127174241945.htm.&nbsp;<\/span><\/p>\n<p style=\"margin-top: 5px;margin-bottom: 5px;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;\"><br  \/><\/p>\n<section class=\"\" style=\"max-width: 100%;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin: 20px 10px;max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin: 10px;max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;border-bottom: 1px solid rgb(160, 160, 160);width: 637px;word-wrap: break-word !important;\"><\/section>\n<\/section>\n<section style=\"margin-top: -10px;max-width: 100%;letter-spacing: 1px;text-align: right;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin-top: -1em;padding-right: 12px;padding-left: 12px;max-width: 100%;box-sizing: border-box;border-radius: 1em;display: inline-block;vertical-align: top;background: -webkit-linear-gradient(right, rgb(56, 116, 241), rgba(255, 247, 234, 0)) rgb(138, 229, 237);height: 1.8em;line-height: 1.8em;color: white;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\">\u7248\u6743\u58f0\u660e<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin: 5px 16px;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;font-family: sans-serif;font-size: 14px;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;text-indent: 0em;font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(120, 172, 254);box-sizing: border-box !important;word-wrap: break-word !important;\">\u6b22\u8fce\u4e2a\u4eba\u3001\u7f51\u7ad9\u3001\u516c\u4f17\u53f7\u7b49\u5f15\u7528\u3001\u8f6c\u8f7d\u548c\u5206\u4eab\u3002\u975e\u4e2a\u4eba\u8f6c\u8f7d\u6216\u5f15\u7528\u672c\u7f51\u7248\u6743\u6240\u6709\u5185\u5bb9\u987b\u83b7\u5f97\u6388\u6743\u5e76\u5728\u9192\u76ee\u5904\u6ce8\u660e\u201c\u8f6c\u81ea\uff1a\u201d\u3002\u6b22\u8fce\u5408\u4f5c\uff0c\u8bf7\u8054\u7cfbiddds@simm.ac.cn<\/span><\/strong><\/p>\n<p><br  \/><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u75be\u75c5\u6982\u51b5 \u4f5c\u4e3a\u5168\u7403\u6027\u6d41\u884c\u75c5\u7684\u6162\u6027\u80be\u75c5\uff08Chronic kidney disease\uff0cCKD\uff09\u662f\u5404\u79cd\u539f\u56e0\u5f15\u8d77\u7684\u6162 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":78298,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/78297"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=78297"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/78297\/revisions"}],"predecessor-version":[{"id":78306,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/78297\/revisions\/78306"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/78298"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=78297"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=78297"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=78297"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}