{"id":78335,"date":"2018-12-26T00:00:50","date_gmt":"2019-02-01T06:16:11","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/78335\/"},"modified":"2019-02-01T14:16:12","modified_gmt":"2019-02-01T06:16:12","slug":"a71ec33851","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/78335\/","title":{"rendered":"\u9884\u6d4b | 2019\u5e74\u5168\u7403\u7545\u9500\u836f\u7269TOP10"},"content":{"rendered":"
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\u6587<\/span><\/strong><\/span><\/strong>\uff1a\u98ce\u4e91<\/span><\/strong><\/span><\/strong><\/strong><\/span><\/p>\n

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2019\u5e74\u5168\u7403\u7545\u9500\u836f\u7269TOP10\u9884\u6d4b<\/strong><\/span>\"\u9884\u6d4b<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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 <\/span>Imbruvica \u4ebf\u73c2<\/span><\/strong><\/span><\/span><\/p>\n

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 <\/span> <\/span><\/strong><\/span>Enbrel \u6069\u5229<\/span><\/strong><\/span><\/p>\n

Enbrel\u901a\u7528\u540d\u4e3a\u4f9d\u90a3\u897f\u666e\uff08etanercept\uff09\u662f\u4e00\u79cd\u9776\u5411\u4e8eTNF\u03b1\u7684\u91cd\u7ec4DNA\u878d\u5408\u86cb\u767d\u836f\u7269\uff0c\u6b64\u836f\u5206\u522b\u57281998\u5e74\u548c2002\u5e74\u5728\u7f8e\u56fd\u548c\u6b27\u6d32\u4e0a\u5e02\uff0c\u5176\u9002\u5e94\u75c7\u5305\u62ec\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u3001\u6591\u5757\u578b\u94f6\u5c51\u75c5\u3001\u94f6\u5c51\u75c5\u5173\u8282\u708e\u3001\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u53ca\u5e7c\u5e74\u7279\u53d1\u6027\u5173\u8282\u708e\u7b49\u3002Enbrel\u7684\u9500\u552e\u6743\u7531Amgen\u3001Pfizer\u548cTakeda\u5171\u540c\u4eab\u6709\u3002\u5176\u4e2dAmgen\u8d1f\u8d23\u7f8e\u56fd\u5e02\u573a\uff1bTakeda\u8d1f\u8d23\u65e5\u672c\u5e02\u573a\uff1bPfizer\u5219\u8d1f\u8d23\u9664\u7f8e\u56fd\u548c\u65e5\u672c\u4e4b\u5916\u5176\u5b83\u5730\u533a\u7684\u5e02\u573a\u3002Enbrel\u5728\u6b27\u6d32\u7684\u4e13\u5229\u57282015\u5e74\u5230\u671f\uff0c\u73b0\u5728\u5df2\u7ecf\u6709\u4eff\u5236\u836f\u4e0a\u5e02\uff0c\u5373Samsung Bioepis\u7684Benepali\uff1b\u5728\u7f8e\u56fd\u5e02\u573a\uff0c\u5c71\u5fb7\u58eb\u5f00\u53d1\u7684Erelzi \u5df2\u4e8e2016\u5e74\u83b7\u6279\uff0c\u4f46\u662f\u7531\u4e8e\u5b89\u8fdb\u65b9\u9762\u8fdb\u884c\u4e86\u4e13\u5229\u4fb5\u6743\u8bc9\u8bbc\uff0c\u56e0\u6b64Erelzi\u5e76\u6ca1\u6709\u8fdb\u5165\u5e02\u573a\u3002<\/span>\u6069\u5229\u7684\u9500\u552e\u989d\u4e3b\u8981\u6765\u81ea\u7f8e\u56fd\u5e02\u573a\uff0c\u56e0\u6b64\u672a\u6765\u5176\u9500\u552e\u989d\u4e0d\u4f1a\u6709\u5f88\u5927\u7684\u4e0b\u6ed1\uff0c\u9884\u8ba12019\u5e74\u9500\u552e\u989d\u8fbe73.32\u4ebf\u7f8e\u5143\u3002<\/strong><\/span><\/p>\n

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 <\/span>  <\/span><\/span><\/strong><\/span>Eylea \u827e\u529b\u96c5<\/span><\/strong><\/span><\/p>\n

Eylea\u901a\u7528\u540d\u4e3a\u963f\u67cf\u897f\u666e\uff0c\u5c5e\u4e8eVEGF\u6291\u5236\u5242\u3002Eylea\u4e0eVEGF\u5bb6\u65cf\u5404\u6210\u5458\uff08\u5305\u62ecVEGF-A\uff09\u53ca\u80ce\u76d8\u751f\u957f\u56e0\u5b50\u5177\u6709\u6781\u9ad8\u7684\u4eb2\u548c\u529b\uff0c\u4ece\u800c\u6291\u5236\u8fd9\u4e9b\u56e0\u5b50\u4e0e\u540c\u6e90VEGF\u53d7\u4f53\u7684\u7ed3\u5408\uff0c\u56e0\u6b64Eylea\u53ef\u6291\u5236\u5f02\u5e38\u7684\u8840\u7ba1\u751f\u6210\u53ca\u6e17\u6f0f\u3002\u5b83\u7406\u8bba\u4e0a\u5177\u6709\u6297\u80bf\u7624\u7684\u4f5c\u7528\uff08\u53c2\u89c1\u963f\u74e6\u65af\u6c40\uff09\uff0c\u4e8b\u5b9e\u4e0a\uff0c\u518d\u751f\u5143\u4e5f\u8fdb\u884c\u8fc7\u6b64\u836f\u7528\u4e8e\u80ba\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u524d\u5217\u817a\u764c\u7b49\u591a\u79cd\u764c\u75c7\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u7136\u800c\u5e76\u6ca1\u6709\u83b7\u5f97\u5f88\u597d\u7684\u6548\u679c\u3002\u6b63\u6240\u8c13\u4e1c\u65b9\u4e0d\u4eae\u897f\u65b9\u4eae\uff0c\u7531\u4e8e\u5b83\u80fd\u6291\u5236\u8840\u7ba1\u751f\u6210\u53ca\u6e17\u6f0f\u7684\u4f5c\u7528\uff0c\u4e34\u5e8a\u4e0a\u53d1\u73b0\u5b83\u5728\u7528\u4e8e\u6cbb\u7597\u591a\u79cd\u773c\u79d1\u75be\u75c5\u4e0a\u6709\u975e\u5e38\u663e\u8457\u7684\u529f\u6548\u3002\u76ee\u524d\uff0cEylea\u88abFDA\u6279\u51c6\u7684\u9002\u5e94\u75c7\u5305\u62ec\u6e7f\u6027\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\u3001\u89c6\u7f51\u819c\u9759\u8109\u963b\u585e\u7ee7\u53d1\u9ec4\u6591\u6c34\u80bf\u3001\u7cd6\u5c3f\u75c5\u6027\u9ec4\u6591\u6c34\u80bf\u3001\u7cd6\u5c3f\u75c5\u89c6\u7f51\u819c\u75c5\u53d8\u7b49\u3002\u5728\u4e2d\u56fd\u5e02\u573a\uff0cEylea\u4e8e\u4eca\u5e742\u6708\u83b7\u6279\uff0c\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u7cd6\u5c3f\u75c5\u6027\u9ec4\u6591\u6c34\u80bf\u3002Eylea\u6700\u521d\u662f\u7531\u518d\u751f\u5143\u5f00\u53d1\u7684\uff0c\u5b83\u8d1f\u8d23\u7f8e\u56fd\u7684\u9500\u552e\uff0c\u800c\u7f8e\u56fd\u5916\u7684\u9500\u552e\u6743\u8f6c\u8ba9\u7ed9\u62dc\u8033\uff0c\u5e76\u6536\u53d650%\u7684\u9500\u552e\u63d0\u6210\u3002Eylea\u57282011\u5e74\u4e0a\u5e02\u540e\u9500\u552e\u989d\u4e00\u8def\u6500\u5347\uff0c<\/span>2018\u5e74\u524d\u4e09\u5b63\u5ea6\u5df2\u7ecf\u8d85\u8fc749\u4ebf\u7f8e\u5143\uff0c\u9884\u6d4b2019\u5e74\u5c06\u8fbe\u523078.56\u4ebf\u7f8e\u5143\u3002<\/strong><\/span><\/p>\n


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 <\/span> Opdivo \u6b27\u72c4\u6c83<\/span><\/span><\/strong><\/span><\/span><\/p>\n

Opdivo\u4e8e2014\u5e74\u5728\u65e5\u672c\u4e0a\u5e02\uff0c\u6210\u4e3a\u5168\u7403\u9996\u4e2a\u88ab\u6279\u51c6\u4e0a\u5e02\u7684PD-1\u5355\u514b\u9686\u6297\u4f53\u3002PD1\u6291\u5236\u5242\u53ef\u4ee5\u91cd\u65b0\u6fc0\u6d3b\u75c5\u4eba\u88ab\u6291\u5236\u7684\u514d\u75ab\u80fd\u529b\uff0c\u6fc0\u53d1\u75c5\u4eba\u81ea\u8eab\u7684\u514d\u75ab\u7cfb\u7edf\u53d1\u6325\u6297\u80bf\u7624\u7684\u4f5c\u7528\uff0c\u4e0e\u4e4b\u524d\u76f4\u63a5\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u7684\u6cbb\u7597\u624b\u6bb5\u5b8c\u5168\u4e0d\u540c\u3002<\/span>BMS\u4e00\u76f4\u6ca1\u6709\u505c\u6b62\u5bf9Opdivo\u7684\u5f00\u53d1\uff0c\u4ece2014\u5e74\u4ee5\u6765\u5b83\u88ab\u6279\u51c6\u7684\u4e0a\u5e02\u7684\u9002\u5e94\u75c7\u5df2\u7ecf\u591a\u8fbe9\u4e2a<\/span><\/strong>\uff0c\u51e0\u4e4e\u5305\u62ec\u6240\u6709\u5e38\u89c1\u7684\u764c\u75c7\uff0c\u5982\u7ecf\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u3001\u809d\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u9ed1\u8272\u7d20\u7624\uff0c\u80ba\u764c\u7b49\u3002\u5728\u521a\u4e0a\u5e02\u76843\u5e74\u91ccOpdvio\u5728PD-1\u6291\u5236\u5242\u5e02\u573a\u4e0a\u9065\u9065\u9886\u5148\uff0c\u4f46\u662f\u4ece2016\u5e74\u4e0b\u534a\u5e74\u5f00\u59cbOpdivo\u5728\u6cbb\u7597\u80ba\u764c\u7684\u4e34\u5e8a\u7814\u7a76\u4e2d\u63a5\u8fde\u906d\u9047\u5931\u8d25\uff1a2016\u5e748\u6708Opdivo\u4e00\u7ebf\u5355\u836f\u6cbb\u7597\u665a\u671fNSCLC\uff08PD-L1 \u8868\u8fbe\u6c34\u5e73\u22655%\uff09CheckMate-026 III\u671f\u7814\u7a76\u5931\u8d25\uff1b2018\u5e7410\u6708Opdivo\u4f5c\u4e3a\u5355\u836f\u7597\u6cd5\u4e8c\u7ebf\u6cbb\u7597\u5c0f\u7ec6\u80de\u80ba\u764c\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u672a\u80fd\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\uff1b11\u6708BMS\u5ba3\u5e03Opdivo+Yervoy\u4f5c\u4e3a\u5c0f\u7ec6\u80de\u80ba\u764c\u7ef4\u6301\u7597\u6cd5\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e5f\u672a\u80fd\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\u2026\u2026\u8981\u77e5\u9053\u80ba\u764c\u662f\u6700\u5e38\u89c1\u7684\u764c\u75c7\uff0c\u62e5\u6709\u6700\u5e7f\u9614\u7684\u5e02\u573a\u3002<\/span>Opdivo\u7684\u63a5\u8fde\u5931\u8d25\u5927\u5927\u5f71\u54cd\u4e86\u5176\u9500\u552e\u8868\u73b0\uff0c2018\u5e74Q2\u7684\u9500\u552e\u989d\u5df2\u7ecf\u88abKeytruda\u53cd\u8d85\uff0c\u4e1a\u5185\u666e\u904d\u8ba4\u4e3a\u5dee\u8ddd\u5c06\u8d8a\u6765\u8d8a\u5927\u3002<\/span><\/strong>\u867d\u7136\u5728\u4e0eKeytruda\u7684\u7ade\u4e89\u4e2d\u5904\u4e8e\u4e0b\u98ce\uff0cOpdivo\u7684\u9500\u552e\u4f53\u91cf\u4f9d\u7136\u662f\u975e\u5e38\u60ca\u4eba\u7684\uff0c2018\u5e74\u524d\u4e09\u5b63\u5ea6\u8fbe\u523049.31\u4ebf\u7f8e\u5143\uff0c\u9884\u6d4b2019\u5e74\u5c06\u8fbe\u523079.58\u4ebf\u7f8e\u5143\u3002<\/span><\/p>\n


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4<\/p>\n<\/section>\n

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 <\/span> <\/span><\/strong><\/span>Keytruda \u53ef\u745e\u8fbe<\/span><\/strong><\/span><\/p>\n

Keytruda\u662f\u9996\u4e2a\u88abFDA\u6279\u51c6\u4e0a\u5e02\u7684PD-1\u5355\u6297\uff0c\u5b83\u548cOpdivo\u5728PD-1\u6291\u5236\u5242\u7684\u5e02\u573a\u4e0a\u7684\u7ade\u4e89\u4e5f\u9887\u6709\u770b\u70b9\u548c\u5bcc\u6709\u620f\u5267\u6027\uff0c\u5b83\u4eec\u540c\u65f6\u57282014\u5e74\u672b\u4e0a\u5e02\uff0c2018\u5e74\u4e2d\u671f\u53c8\u88ab\u5f15\u5165\u4e2d\u56fd\u5e02\u573a\u3002Opdivo \u66fe\u7ecf\u9065\u9065\u9886\u5148\uff0c\u524d\u6587\u6307\u51fa\u5b83\u6700\u8fd1\u51e0\u5e74\u6709\u591a\u4e2a\u5173\u952e\u4e34\u5e8a\u9879\u76ee\u5931\u8d25\uff0c\u4e0e\u4e4b\u5bf9\u6bd4\u7684\u662f<\/span>Keyturda\u6700\u8fd1\u51e0\u5e74\u5728\u4e34\u5e8a\u5ba1\u6279\u4e0a\u4e00\u8def\u7eff\u706f\uff0c\u622a\u6b622018\u5e7411\u6708\uff0c\u5b83\u83b7\u6279\u7684\u9002\u5e94\u75c7\u5df2\u7ecf\u591a\u8fbe14\u79cd\uff0c\u662f\u9002\u5e94\u75c7\u8303\u56f4\u6700\u5e7f\u7684\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u836f\u7269<\/strong><\/span>\uff0c\u6700\u8fd1\u88ab\u6279\u51c6\u7684\u4e24\u79cd\u9002\u5e94\u75c7\u5206\u522b\u662f\uff1a\u5148\u524d\u5df2\u63a5\u53d7\u9776\u5411\u836f\u7269sorafenib\uff08\u7d22\u62c9\u975e\u5c3c\uff09\u6cbb\u7597\u7684\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\uff0c\u4ee5\u53ca\u8054\u5408\u5316\u7597\u7528\u4e8e\u8f6c\u79fb\u6027\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08squamous NSCLC\uff09\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\uff0c\u8fd9\u4e24\u4e2a\u5ba1\u6279\u975e\u5e38\u5173\u952e\uff0c\u56e0\u4e3a\u80ba\u764c\u548c\u809d\u764c\u5206\u522b\u662f\u5168\u7403\u53d1\u75c5\u7387\u524d\u4e24\u4f4d\u7684\u764c\u75c7\uff0c\u5e02\u573a\u5bb9\u91cf\u5de8\u5927\u3002\u6b64\u5916\uff0c2017\u5e745\u6708\uff0cFDA\u52a0\u901f\u6279\u51c6\u4e86keytruda\u7528\u4e8e\u4e0d\u53ef\u5207\u9664\u6216\u8005\u8f6c\u79fb\u7684\u5fae\u536b\u661f\u9ad8\u5ea6\u4e0d\u7a33\u5b9a\uff08MSI-H)\u6216\u9519\u914d\u4fee\u590d\u7f3a\u9677\uff08dMMR\uff09\u7684\u5b9e\u4f53\u80bf\u7624\u60a3\u8005\uff0c\u6ce8\u610f\u8fd9\u6b21\u6279\u51c6\u5e76\u4e0d\u5c40\u9650\u67d0\u4e00\u79cd\u80bf\u7624\uff0c<\/span>\u8fd9\u662fFDA\u9996\u6b21\u7ed9\u4e88\u8fd9\u79cd\u6279\u51c6\uff0c\u5373\u6240\u8c13\u7684\u201ctissue\/site-agnostic approval\u201d(\u4e0d\u9650\u7ec4\u7ec7\u4f4d\u70b9\u6279\u51c6\uff09\uff0c\u5373\u4e0d\u8bba\u662f\u54ea\u4e2a\u90e8\u4f4d\u7684\u80bf\u7624\u53ea\u8981\u5177\u6709\u4ee5\u4e0a\u7279\u5b9a\u80bf\u7624\u6807\u8bb0\u7269\u5c31\u53ef\u9002\u7528\u3002<\/strong><\/span>\u8fd9\u65e0\u7591\u5177\u6709\u91cc\u7a0b\u7891\u610f\u4e49\uff0c\u9500\u552e\u989d\u4e00\u8def\u6500\u5347\u4e5f\u662f\u6c34\u5230\u6e20\u6210\u7684\u4e8b\u4e86\uff0c2018\u5e74\u524d\u4e09\u5b63\u5ea6\u9500\u552e\u989d\u8d85\u8fc750\u4ebf\u7f8e\u5143\uff0c\u9884\u6d4b2019\u5e74\u9500\u552e\u989d100.07\u4ebf\u7f8e\u5143\u3002<\/span><\/p>\n


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 <\/span> <\/span><\/strong><\/span>Eliquis \u827e\u4e50\u59a5<\/span><\/strong><\/span><\/p>\n

\u827e\u4e50\u59a5\u901a\u7528\u540dApixaban\uff08\u963f\u54cc\u6c99\u73ed),\u662f\u8f89\u745e\u548cBMS\u5171\u540c\u5f00\u53d1\u7684\u4e00\u79cd\u53e3\u670d\u5c0f\u5206\u5b50\u6297\u8840\u51dd\u5242\uff0c\u5b83\u53ef\u4ee5\u76f4\u63a5\u6291\u5236\u56e0\u5b50Xa\uff0c2012\u5e74\u4e0a\u5e02\uff0c\u76ee\u524d\u5df2\u7ecf\u88ab\u6279\u51c6\u7528\u4e8e\u9884\u9632\u6210\u4eba\u5168\u9acb\u6216\u5168\u819d\u5173\u8282\u7f6e\u6362\u672f\u540e\u9759\u8109\u8840\u6813\u6813\u585e\u75c7\uff0c\u9884\u9632\u975e\u74e3\u819c\u6027\u623f\u98a4\u60a3\u8005\u5352\u4e2d\u548c\u4f53\u5faa\u73af\u6813\u585e\uff0c\u6cbb\u7597\u6df1\u9759\u8109\u8840\u6813\u6813\u585e\u75c7\u548c\u80ba\u6813\u585e\uff0c\u4ee5\u53ca\u9884\u9632\u6df1\u9759\u8109\u8840\u6813\u548c\u80ba\u6813\u585e\u7684\u590d\u53d1\u3002<\/span>\u7531\u4e8e\u6b64\u836f\u5728\u672f\u540e\u6cbb\u7597\u4ee5\u53ca\u5fc3\u8840\u7ba1\u75be\u75c5\u4e2d\u7684\u5e7f\u6cdb\u5e94\u7528\uff0c\u5176\u9500\u552e\u989d\u4e0d\u65ad\u6500\u5347\uff0c2017\u5e74\u4ee5\u6765\u6bcf\u4e2a\u5b63\u5ea6\u7684\u589e\u957f\u7387\u63a5\u8fd110\u4e2a\u767e\u5206\u70b9\uff0c2017\u5e74\u5df2\u7ecf\u8d85\u8fc7Xarelto\u6210\u4e3a\u6700\u7545\u9500\u7684\u6297\u8840\u51dd\u5242\u3002<\/span><\/strong>\u6709\u7814\u7a76\u663e\u793aEliquis\u7684\u957f\u671f\u5b89\u5168\u6027\u4f18\u4e8e\u7ade\u4e89\u5bf9\u624b\uff0c\u540c\u65f6\u5c31\u964d\u4f4e\u51fa\u8840\u98ce\u9669\u6765\u8bf4\uff0cEliquis\u53ef\u80fd\u5b58\u5728\u6f5c\u5728\u7684\u6536\u76ca\uff0c\u63a8\u52a8\u5176\u9500\u552e\u989d\u589e\u957f\u3002\u901a\u8fc7\u67e5\u9605BMS\u548c\u8f89\u745e2018\u5e74\u7684\u5b63\u62a5\u7edf\u8ba1\uff0c2018\u5e74\u524d\u4e09\u5b63\u5ea6Eliquis\u7684\u9500\u552e\u603b\u989d\u5df2\u7ecf\u8fbe\u523072.6\u4ebf\u7f8e\u5143\uff0c\u9884\u6d4b2019\u5e74\u9500\u552e\u989d101.84\u4ebf\u7f8e\u5143\u3002<\/span><\/p>\n


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 <\/span> <\/span><\/strong><\/span>Revlimid \u745e\u590d\u7f8e<\/span><\/strong><\/span><\/p>\n

\u6765\u90a3\u5ea6\u80fa\u7684\u5f00\u53d1\u53ef\u4ee5\u8bf4\u662f\u4e00\u4e2a\u5076\u7136\uff0c\u5b83\u7684\u524d\u4f53\u662f\u4e0a\u4e16\u7eaa50\u5e74\u4ee3\u66fe\u5f15\u53d11\u4e07\u591a\u4f8b\u7578\u5f62\u513f\u7684\u6c99\u7acb\u5ea6\u80fa(\u53cd\u5e94\u505c)\uff0c\u4f46\u662f\u4e0a\u4e16\u7eaa\u672b\u4eba\u4eec\u53d1\u73b0\u5176\u5177\u6709\u5f88\u5f3a\u7684\u6297\u708e\u548c\u6297\u8840\u7ba1\u751f\u6210\u4f5c\u7528\uff0c\u7ecf\u8fc7\u6539\u9020\u6210\u4e3a\u6765\u90a3\u5ea6\u80fa\uff0c\u6b64\u836f\u901a\u8fc7\u591a\u79cd\u673a\u5236\u53d1\u6325\u6297\u80bf\u7624\u4f5c\u7528,\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u6297\u8840\u7ba1\u751f\u6210\u3001\u514d\u75ab\u8c03\u8282\u3001\u8bf1\u53d1\u764c\u7ec6\u80de\u51cb\u4ea1\u7b49\u3002Revlimid 2006\u5e74\u9996\u6b21\u88abFDA\u6279\u51c6\u8054\u5408\u5730\u585e\u7c73\u677e\u7528\u4e8e\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684\u4e8c\u7ebf\u6cbb\u7597\uff0c\u76ee\u524d\u9664\u4e86\u5df2\u7ecf\u5e7f\u6cdb\u5e94\u7528\u4e8e\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u6cbb\u7597\u5916\uff0c\u5b83\u7684\u9002\u5e94\u75c7\u8303\u56f4\u4e0d\u65ad\u6269\u5927\uff1a\u5305\u62ec\u9aa8\u9ad3\u589e\u751f\u5f02\u5e38\u7efc\u5408\u75c7\uff0c\u590d\u53d1\u6216\u8005\u96be\u6cbb\u7684\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff0c\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e24\u6b21\u6cbb\u7597\u7684\u5957\u7ec6\u80de\u6dcb\u5df4\u7624\uff0c\u5f25\u6563\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u7624\uff0c\u9020\u8840\u79fb\u690d\u540e\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u7684\u7ef4\u6301\u6cbb\u7597\u7b49\u3002\u5176\u6f5c\u5728\u7684\u9002\u5e94\u75c7\u8fd8\u5305\u62ec\u60f0\u6027\u6dcb\u5df4\u7624\u4ee5\u53ca\u5176\u4ed6\u591a\u79cd\u5b9e\u4f53\u7624\u3002<\/span>2016\u5e74\uff0cRevlimid\u8d85\u8d8a\u7f8e\u7f57\u534e\u6210\u4e3a\u5168\u7403\u6700\u7545\u9500\u7684\u6297\u80bf\u7624\u836f\u7269\uff0c<\/strong><\/span>\u5728\u5355\u6297\u3001\u878d\u5408\u86cb\u767d\u7b49\u751f\u7269\u836f\u84ec\u52c3\u53d1\u5c55\u7684\u4eca\u5929Revlimid \u4f5c\u4e3a\u4e00\u79cd\u4f20\u7edf\u7684\u5c0f\u5206\u5b50\u836f\u7269\u8fd8\u80fd\u4fdd\u6301\u5feb\u901f\u589e\u957f\u7684\u52bf\u5934\uff0c\u4e0d\u5f97\u4e0d\u4ee4\u4eba\u79f0\u9053\u3002<\/span>\u6b64\u836f\u6700\u8fd1\u51e0\u5e74\u90fd\u4e0d\u4f1a\u9047\u5230\u4e13\u5229\u95ee\u9898\uff0c\u56e0\u6b64\u8fdc\u6ca1\u6709\u8fbe\u5230\u9500\u552e\u5cf0\u503c\uff0c2018\u5e74\u524d\u4e09\u5b63\u5ea6\u9500\u552e\u989d\u8fbe\u523071.36\u4ebf\u7f8e\u5143\uff0c\u9884\u6d4b2019\u5e74\u9500\u552e\u989d110.87\u4ebf\u7f8e\u5143\u3002<\/strong><\/span><\/p>\n

 <\/span><\/p>\n

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 <\/span>Humira\u4fee\u7f8e\u4e50<\/span><\/strong><\/span><\/p>\n

\u81ea2012\u5e74\u8d77\uff0c\u4fee\u7f8e\u4e50\u5c31\u6210\u4e3a\u5168\u7403\u6700\u7545\u9500\u836f\u7269\uff0c\u5b83\u7684\u901a\u7528\u540d\u4e3a\u963f\u8fbe\u6728\u5355\u6297\uff0c\u9776\u5411\u4e8eTNF\u03b1\u963b\u6b62\u5176\u4e0eTNF\u53d7\u4f53\u7684\u7ed3\u5408\u4ece\u800c\u6291\u5236\u4e86TNF\u03b1\u5f15\u53d1\u7684\u708e\u75c7\u53cd\u5e94\u3002Humira\u4e4b\u6240\u4ee5\u6709\u8fd9\u4e48\u9ad8\u7684\u9500\u552e\u989d\u6709\u591a\u65b9\u9762\u7684\u56e0\u7d20:\u9996\u5148\uff0c\u4f5c\u4e3a\u5168\u7403\u9996\u4e2a\u5168\u4eba\u6e90TNFa\u6297\u4f53\uff0c\u5b83\u7684<\/span>\u836f\u6548\u4f5c\u7528\u8fc7\u786c<\/strong><\/span>\uff1b\u5176\u6b21\uff0cTNFa\u6297\u4f53\u7406\u8bba\u4e0a\u53ef\u4ee5\u5e7f\u6cdb\u7684\u5e94\u7528\u4e8e\u5404\u79cd\u514d\u75ab\u5931\u8c03\u75be\u75c5\uff0c\u800c\u827e\u4f2f\u7ef4\u5c31\u52aa\u529b\u7684\u4f7f\u8fd9\u79cd\u7406\u8bba\u53d8\u4e3a\u4e8b\u5b9e\uff0c\u5b83\u4e00\u76f4\u4ee5\u6765\u90fd\u6ca1\u6709\u505c\u6b62\u5bf9\u4fee\u7f8e\u4e50\u7684\u7814\u7a76\uff0c\u4e0d\u65ad\u6269\u5c55\u5176\u9002\u5e94\u75c7\u8303\u56f4\uff0c\u636e<\/span>\u4e0d\u5b8c\u5168\u7edf\u8ba1\u5176\u5728\u5168\u7403\u7684\u9002\u5e94\u75c7\u5df2\u7ecf\u63a5\u8fd120\u4e2a<\/span><\/strong>\uff1b\u518d\u6b21\uff0c\u5728\u4e13\u5229\u65b9\u9762\u827e\u4f2f\u7ef4\u662f\u505a\u8db3\u4e86\u5de5\u4f5c\uff0c\u5bf9\u4e8e\u521b\u65b0\u836f\u800c\u8a00\uff0c\u4e13\u5229\u5c31\u662f\u9ad8\u989d\u9500\u552e\u7684\u4fdd\u8bc1\uff0c\u4e3a\u4e86\u907f\u514d\u4e13\u5229\u5230\u671f\u800c\u9500\u552e\u989d\u65ad\u5d16\u5f0f\u4e0b\u6ed1\u7684\u73b0\u8c61\uff0c\u827e\u4f2f\u7ef4\u5bf9Humira<\/span>\u5728\u5168\u7403\u7684\u4e13\u5229\u8fdb\u884c\u4e86\u5168\u65b9\u4f4d\u7684\u7533\u8bf7<\/strong><\/span>\uff0c\u5305\u62ec\u5316\u5408\u7269\u3001\u5236\u5242\u3001\u5236\u5907\u5de5\u827a\u3001\u9002\u5e94\u75c7\u3001\u4f7f\u7528\u65b9\u6cd5\u7b49\u591a\u4e2a\u65b9\u9762\uff0c\u5f62\u6210\u4e86\u4e00\u9053\u9053\u4e13\u5229\u5c4f\u969c\u3002\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u5373\u4f7fHumira\u7684\u4e13\u5229\u5728\u6b27\u6d32\u5df2\u7ecf\u8fc7\u671f\uff0c\u800c\u4e14\u5df2\u7ecf\u6709\u591a\u4e2a\u751f\u7269\u7c7b\u4f3c\u836f\u7269\u4e0a\u5e02\uff0c\u672a\u6765\u51e0\u5e74\u5176\u9500\u552e\u989d\u4e5f\u4e0d\u4f1a\u6709\u5927\u7684\u7684\u4e0b\u6ed1\u3002\u5728\u4e13\u5229\u8bc9\u8bbc\u4e0a\uff0c\u827e\u4f2f\u7ef4\u4f7f\u7528\u4e86\u201c\u653e\u5c0f\u4fdd\u5927\u201d\u7684\u7b56\u7565\uff0cHumira\u7684\u5728\u7f8e\u56fd\u7684\u9500\u552e\u989d\u53607\u6210\u5de6\u53f3\uff0c\u800c\u5728\u6b27\u6d32\u5730\u533a\u4ec5\u536030%\uff0c\u5bf9\u4e8e\u5df2\u7ecf\u88ab\u6279\u51c6\u7684\u751f\u7269\u7c7b\u4f3c\u836f\u7269\uff0c\u827e\u4f2f\u7ef4\u4e0e\u8be5\u516c\u53f8\u8fbe\u6210\u534f\u8bae\u5141\u8bb8\u5728\u6b27\u6d32\u5730\u533a\u4e0a\u5e02\uff0c\u800c\u5728\u7f8e\u56fd\u5e02\u573a\u81f3\u5c11\u8981\u52302023\u5e74\u4ee5\u540e\u624d\u5141\u8bb8\u4e0a\u5e02\uff0c\u76ee\u524d\u5df2\u7ecf\u6709\u5305\u62ec\u8f89\u745e\u3001\u5b89\u8fdb\u7b497\u5bb6\u516c\u53f8\u4e0e\u827e\u4f2f\u7ef4\u8fbe\u6210\u7c7b\u4f3c\u7684\u534f\u8bae\uff0c<\/span>\u56e0\u6b64Humira\u8fd8\u5c06\u8749\u8054\u5168\u7403\u6700\u7545\u9500\u836f\u7269\uff0c\u9884\u6d4b2019\u5e74\u9500\u552e\u989d208.83\u4ebf\u7f8e\u5143<\/strong><\/span><\/p>\n


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