{"id":78357,"date":"2018-12-21T00:00:50","date_gmt":"2019-02-01T06:16:23","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/78357\/"},"modified":"2019-02-01T14:16:24","modified_gmt":"2019-02-01T06:16:24","slug":"767d082bf0","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/78357\/","title":{"rendered":"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c45\u671f\uff09"},"content":{"rendered":"
\n

\u56fd\u5916\u836f\u7269\u7814\u53d1\u52a8\u6001<\/span><\/strong><\/span><\/p>\n

1. FDA\u5ba3\u5e03\uff0c\u6279\u51c6Shire\u516c\u53f8\u6cbb\u7597\u6162\u6027\u7279\u53d1\u6027\u4fbf\u79d8\uff08CIC\uff09\u7684Motegrity\uff08prucalopride\uff09\u4e0a\u5e02\u3002\u8fd9\u4e5f\u662fFDA\u4eca\u5e74\u6279\u51c6\u7684\u7b2c56\u6b3e\u65b0\u836f\u3002Prucalopride\u662f\u4e00\u79cd\u9ad8\u4eb2\u548c\u529b\uff0c\u7279\u5f02\u60275-HT4\u53d7\u4f53\u6fc0\u52a8\u5242\u3002\u5b83\u662f\u4e00\u79cd\u80c3\u80a0\u52a8\u529b\u5242\uff0c\u80fd\u591f\u523a\u6fc0\u7ed3\u80a0\u8815\u52a8\uff0c\u52a0\u5feb\u7caa\u4fbf\u8fd0\u52a8\u3002<\/span><\/p>\n

2. Axovant Sciences\u516c\u53f8\u5ba3\u5e03\uff0c\u8be5\u516c\u53f8\u4ece\u9a6c\u8428\u8bf8\u585e\u5927\u5b66\uff08UMass\uff09\u533b\u5b66\u9662\u83b7\u5f97\u4e24\u9879\u521b\u65b0\u57fa\u56e0\u7597\u6cd5\u9879\u76ee\u7684\u5168\u7403\u72ec\u5bb6\u7814\u53d1\u8bb8\u53ef\u3002\u8fd9\u4e24\u9879\u57fa\u56e0\u7597\u6cd5\u5206\u522b\u7528\u4e8e\u6cbb\u7597GM1\u795e\u7ecf\u8282\u82f7\u8102\u75c5\u548cGM2\u795e\u7ecf\u8282\u82f7\u8102\u75c5\uff08\u53c8\u540dTay-Sachs\u548cSandhoff\u75c5\uff09\u3002<\/span><\/p>\n

3. \u97e9\u56fd\u751f\u7269\u5236\u836f\u516c\u53f8trion\u4e0e\u5408\u4f5c\u4f19\u4f34\u68af\u74e6\uff08Teva\uff09\u8fd1\u65e5\u5ba3\u5e03\uff0cFDA\u5df2\u6279\u51c6\u66f2\u59a5\u73e0\u5355\u6297\u751f\u7269\u4eff\u5236\u836fHerzuma\uff08trastuzumab-pkrb\uff09\uff0c\u7528\u4e8eHER2\u9633\u6027\u4e73\u817a\u764c\u6cbb\u7597\u3002Herzuma\u6240\u9488\u5bf9\u7684\u54c1\u724c\u836f\u4e3a\u7f57\u6c0f\u7684\u8d85\u7ea7\u91cd\u78c5\u4ea7\u54c1Herceptin\uff08\u8d6b\u8d5b\u6c40\uff0c\u901a\u7528\u540d\uff1atrastuzumab\uff0c\u66f2\u59a5\u73e0\u5355\u6297\uff09\u3002<\/span><\/p>\n

4. Evofem Biosciences\u516c\u53f8\u5ba3\u5e03\uff0c\u65d7\u4e0b\u5019\u9009\u4ea7\u54c1Amphora\u7528\u4e8e\u5973\u6027\u907f\u5b55\u7814\u7a76\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff08AMPOWER\uff09\u6210\u529f\u5730\u8fbe\u5230\u4e86\u4e3b\u8981\u7ec8\u70b9\u3002Amphora\u662f\u4e00\u79cdL-\u4e73\u9178\u3001\u67e0\u6aac\u9178\u548c\u9152\u77f3\u9178\u94be\u5236\u5242\uff0c\u5b83\u662fEvofem\u7684\u591a\u529f\u80fd\u9634\u9053pH\u8c03\u8282\u5668\u2122\uff08MVP-R\uff09\u4e0b\u7684\u4ea7\u54c1\uff0cAmphora\u65e8\u5728\u8c03\u8282\u6b63\u5e38\u8303\u56f4\u51853.5-4.5\u7684\u9634\u9053pH\u503c\uff0c\u8fd9\u4fdd\u8bc1\u4e86\u4e00\u4e2a\u4e0d\u9002\u5408\u7cbe\u5b50\u4ee5\u53ca\u67d0\u4e9b\u75c5\u6bd2\u548c\u7ec6\u83cc\u75c5\u539f\u4f53\u4e0e\u6027\u4f20\u64ad\u611f\u67d3\u3001\u4f46\u5065\u5eb7\u7ec6\u83cc\u5fc5\u4e0d\u53ef\u5c11\u7684\u9178\u6027\u9634\u9053\u751f\u5b58\u73af\u5883\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c45\u671f\uff09\"<\/p>\n

5. \u68af\u74e6\uff08Teva\uff09\u5236\u836f12\u670817\u65e5\u516c\u5e03\u4e86IIIb\u671f\u4e34\u5e8a\u7814\u7a76FOCUS\u7684\u79ef\u6781\u7ed3\u679c\uff0c\u8be5\u7814\u7a76\u8bc4\u4f30\u4e86fremanezumab\u5728\u6210\u4eba\u60a3\u8005\u4e2d\u9884\u9632\u6027\u6cbb\u7597\u504f\u5934\u75db\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002<\/span><\/p>\n

6. \u793c\u6765\u8fd1\u65e5\u516c\u5e03\u4e86\u65b0\u578b\u6297\u708e\u836fTaltz\uff08ixekizumab\uff09\u6cbb\u7597\u94f6\u5c51\u75c5\u5173\u8282\u708e\uff08PsA\uff09\u7684\u2162b\/\u2163\u671f\u4e34\u5e8a\u7814\u7a76SPIRIT-H2H\u7684\u79ef\u6781\u9876\u7ebf\u6570\u636e\u3002\u8be5\u7814\u7a76\u662f\u5728\u6cbb\u7597\u6d3b\u52a8\u6027PsA\u65b9\u9762\u5b8c\u6210\u7684\u9996\u4e2a\u5927\u89c4\u6a21\u5934\u5bf9\u5934\uff08H2H\uff09\u4f18\u8d8a\u6027\u7814\u7a76\uff0c\u540c\u65f6\u662f\u9996\u4e2a\u4e5f\u662f\u552f\u4e00\u4e00\u4e2a\u4f9d\u7167\u6807\u7b7e\u5242\u91cfTaltz\u548cHumira\uff08\u4fee\u7f8e\u4e50\uff09\u7528\u836f\u5e76\u540c\u65f6\u7ed3\u5408\u5e38\u89c4\u75be\u75c5\u4fee\u9970\u6297\u98ce\u6e7f\u836f\u7269\uff08cDMARD\uff09\u6cbb\u7597\u7684H2H\u7814\u7a76\u3002<\/span><\/p>\n

7. \u8bfa\u548c\u8bfa\u5fb7\u5ba3\u5e03\u4e0eStaten Biotechnology\u8fbe\u6210\u5408\u4f5c\u534f\u8bae\uff0c\u4e24\u5bb6\u516c\u53f8\u5c06\u8054\u5408\u5f00\u53d1ApoC3\u6297\u4f53\u6cbb\u7597\u4ea7\u54c1STT-5058\u3002\u901a\u8fc7\u6b64\u6b21\u5408\u4f5c\uff0c\u8bfa\u548c\u5c06\u6709\u673a\u4f1a\u589e\u5f3a\u65d7\u4e0b\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u4ea7\u54c1\u7ebf\u3002<\/span><\/p>\n

8. \u963f\u8bfa\u533b\u836f\u5ba3\u5e03\u5176\u7528\u4e8e\u6cbb\u7597\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c(HNSCC)\u7684\u836f\u7269\u2014\u2014Buparlisib (AN2025) \u7684\u4e09\u671f\u4e34\u5e8a\u65b9\u6848\u8349\u6848\u53ca\u7edf\u8ba1\u5206\u6790\u8ba1\u5212\u8349\u6848\u83b7\u5f97\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u7ba1\u7406\u5c40\uff08FDA\uff09\u8ba4\u53ef\uff0c\u5373\u5c06\u8fdb\u5165III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u540c\u65f6\uff0cFDA\u540c\u610f\u963f\u8bfa\u533b\u836f\u5728\u603b\u6709\u6548\u7387(ORR)\u7684\u671f\u4e2d\u5206\u6790\u7ed3\u679c\u8fbe\u5230\u9884\u8bbe\u7684\u7edf\u8ba1\u5b66\u610f\u4e49\u65f6\u63d0\u524d\u7533\u62a5NDA\uff0c\u5e76\u5c06\u52a0\u901f\u5ba1\u8bc4\uff0c\u8fd9\u610f\u5473\u7740Buparlisib\u672a\u6765\u7684NDA\u7533\u62a5\u6709\u671b\u5927\u5e45\u63d0\u524d\u3002<\/span><\/p>\n

9. Vertex Pharmaceuticals\u516c\u53f8\u4eca\u65e5\u5ba3\u5e03\uff0c\u8be5\u516c\u53f8\u521b\u65b0\u6b62\u75db\u5728\u7814\u836f\u7269VX-150\u5728\u6cbb\u7597\u56e0\u4e3a\u5c0f\u7ea4\u7ef4\u795e\u7ecf\u75c5\u53d8\uff08SFN\uff09\u5bfc\u81f4\u7684\u75bc\u75db\u60a3\u8005\u7684\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\u3002\u8fd9\u662fVX-150\u5728\u7b2c\u4e09\u9879\u6982\u5ff5\u9a8c\u8bc1\u7814\u7a76\u4e2d\u83b7\u5f97\u79ef\u6781\u7ed3\u679c\uff0c\u8868\u660e\u8be5\u836f\u7269\u7684\u9776\u6807NaV1.8\u53ef\u4ee5\u7528\u4e8e\u6cbb\u7597\u591a\u79cd\u75bc\u75db\u3002\u8be5\u516c\u53f8\u540c\u65f6\u5ba3\u5e03\u7f8e\u56fdFDA\u5df2\u7ecf\u6388\u4e88VX-150\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff0c\u7528\u4e8e\u6cbb\u7597\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u75bc\u75db\u3002<\/span><\/p>\n

10. Eiger BioPharmaceuticals\u516c\u53f8\u5ba3\u5e03\uff0c\u8be5\u516c\u53f8\u5f00\u53d1\u7684\u6cbb\u7597\u4e01\u809d\u75c5\u6bd2\uff08HDV\uff09\u611f\u67d3\u7684lonafarnib\u83b7\u5f97FDA\u6388\u4e88\u7684\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u3002Lonafarnib\u662f\u4e00\u79cd\u7528\u4e8e\u6cbb\u7597\u4e01\u578b\u809d\u708e\u7684\u201cfirst-in-class\u201d\u5f02\u620a\u4e8c\u70ef\u5316\u6291\u5236\u5242\u3002<\/span><\/p>\n

11. \u793c\u6765\u516c\u53f8\u5ba3\u5e03\u5176MONARCH 2\u548cMONARCH 3\u8bd5\u9a8c\u7684\u63a2\u7d22\u6027\u4e9a\u7ec4\u5206\u6790\u7ed3\u679c\u53d1\u8868\u5728\u300aNPJ Breast Cancer\u300b\u4e0a\u3002\u8fd9\u4e9b\u8bd5\u9a8c\u7ed3\u679c\u8fdb\u4e00\u6b65\u652f\u6301\u4e86Verzenio\uff08abemaciclib\uff09\u4e0e\u5185\u5206\u6ccc\u7597\u6cd5\u6784\u6210\u7684\u7ec4\u5408\u7597\u6cd5\uff0c\u5728\u6cbb\u7597\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\uff08HR+\uff09\uff0c\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f532\u9634\u6027\uff08HER2-\uff09\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u5973\u6027\u60a3\u8005\u4e2d\u7684\u4e34\u5e8a\u6536\u76ca\u3002<\/span><\/p>\n

12. \u5b89\u8fdb\uff08Amgen\uff09\u4e0eMolecular Partners\u516c\u53f8\u8fd1\u65e5\u8054\u5408\u5ba3\u5e03\u5173\u4e8eMP0310\uff08FAP x 4-1BB\uff09\u7684\u4e34\u5e8a\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u8fbe\u6210\u4e86\u4e00\u9879\u5408\u4f5c\u548c\u8bb8\u53ef\u534f\u8bae\u3002MP0310\u662f\u4e00\u79cd\u4e34\u5e8a\u524d\u5206\u5b50\uff0c\u901a\u8fc7\u7ed3\u5408\u80bf\u7624\u57fa\u8d28\u7ec6\u80de\u4e0a\u7684FAP\uff08\u5b9a\u4f4d\u5668\uff09\u5e76\u901a\u8fc74-1BB\uff08\u514d\u75ab\u8c03\u8282\u5242\uff09\u5171\u523a\u6fc0T\u7ec6\u80de\u6765\u5c40\u90e8\u6fc0\u6d3b\u80bf\u7624\u4e2d\u7684\u514d\u75ab\u7ec6\u80de\u3002\u9996\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u9884\u8ba1\u5c06\u57282019\u5e74\u5f00\u5c55\u3002<\/span><\/p>\n

13. Puma\u751f\u7269\u6280\u672f\u516c\u53f8\u8fd1\u65e5\u516c\u5e03\u4e86\u9776\u5411\u6297\u764c\u836fPB272\uff08neratinib\uff09\u6cbb\u7597HER2\u9633\u6027\u4e73\u817a\u764cIII\u671f\u4e34\u5e8a\u7814\u7a76NALA\u7684\u79ef\u6781\u9876\u7ebf\u6570\u636e\u3002\u4e2d\u5fc3\u5ba1\u67e5\u786e\u8ba4\u7684\u4e3b\u8981\u7ec8\u70b9\u5206\u6790\u663e\u793a\uff0c\u4e0eTykerb+\u5361\u57f9\u4ed6\u6ee8\u6cbb\u7597\u7ec4\u76f8\u6bd4\uff0cneratinib+\u5361\u57f9\u4ed6\u6ee8\u6cbb\u7597\u7ec4PFS\u8868\u73b0\u51fa\u7edf\u8ba1\u5b66\u610f\u4e49\u7684\u663e\u8457\u6539\u5584\uff08p=0.0059\uff09\u3002<\/span><\/p>\n

14. \u767e\u5065\uff08Biogen\uff09\u4e0e\u5408\u4f5c\u4f19\u4f34Alkermes\u8fd1\u65e5\u8054\u5408\u5ba3\u5e03\uff0c\u53cc\u65b9\u5df2\u5411\u7f8e\u56fd\u98df\u54c1\u548c\u836f\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u63d0\u4ea4\u4e86diroximel fumarate\uff08BIIB098\uff09\u7684\u65b0\u836f\u7533\u8bf7\uff08NDA\uff09\uff0c\u8be5\u836f\u662f\u4e00\u79cd\u65b0\u578b\u53e3\u670d\u5bcc\u9a6c\u9178\u836f\u7269\uff0c\u5f00\u53d1\u7528\u4e8e\u590d\u53d1\u578b\u591a\u53d1\u6027\u786c\u5316\u75c7\uff08RMS\uff09\u7684\u6cbb\u7597\u3002<\/span><\/p>\n

15. \u7f57\u6c0f\uff08Roche\uff09\u65d7\u4e0b\u7684\u65e5\u672cChugai\u516c\u53f8\u5ba3\u5e03\uff0c\u8be5\u516c\u53f8\u5f00\u53d1\u7684IL-6\u6297\u4f53satralizumab\u5728\u6cbb\u7597\u89c6\u795e\u7ecf\u810a\u9ad3\u708e\u8c31\u7cfb\u969c\u788d\uff08NMOSD\uff09\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\uff0c\u4f5c\u4e3a\u5355\u836f\u7597\u6cd5\uff0c\u663e\u8457\u964d\u4f4e\u60a3\u8005\u7684\u75be\u75c5\u590d\u53d1\u98ce\u9669\u3002\u540c\u65f6\uff0c\u7f8e\u56fdFDA\u6388\u4e88\u8be5\u7597\u6cd5\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff0c\u7528\u4e8e\u6cbb\u7597NMOSD\/\u89c6\u795e\u7ecf\u810a\u9ad3\u708e\u3002<\/span><\/p>\n

16. \u5409\u5229\u5fb7\u79d1\u5b66\uff08Gilead Sciences\uff09\u548cAgenus\u516c\u53f8\u5ba3\u5e03\uff0c\u4e24\u5bb6\u516c\u53f8\u5728\u764c\u75c7\u514d\u75ab\u5b66\u9886\u57df\u8fbe\u6210\u5408\u4f5c\u534f\u8bae\uff0c\u5c06\u5f00\u53d1\u548c\u63a8\u5e7f\u591a\u8fbe\u4e94\u9879\u7684\u65b0\u578b\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u3002\u5409\u5229\u5fb7\u79d1\u5b66\u5c06\u652f\u4ed8\u7ed9Agenus\u603b\u503c\u4e3a1.5\u4ebf\u7f8e\u5143\u7684\u524d\u671f\u4ed8\u6b3e\u548c\u80a1\u6743\u6295\u8d44\uff0c\u53e6\u6709\u6f5c\u5728\u768417\u4ebf\u7f8e\u5143\u7684\u672a\u6765\u91cc\u7a0b\u7891\u540e\u7eed\u4ed8\u6b3e\u3002<\/span><\/p>\n

17. Allergan\u516c\u53f8\u53d1\u8a00\u4eba\u79f0Botox\u91cd\u5ea6\u6291\u90c1\u75c7\uff08MDD\uff09III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u63a8\u8fdf\u81f32019\u5e74\u4e0b\u534a\u5e74\u5f00\u59cb\u3002Botox\u7531\u5168\u7403\u9886\u5148\u7684\u5236\u836f\u516c\u53f8Allergan\uff08\u827e\u5c14\u5065\uff09\u7814\u53d1\uff0c\u4e3b\u8981\u6210\u5206\u662f\u9ad8\u5ea6\u7eaf\u5316\u7684A\u578b\u8089\u6bd2\u6746\u83cc\u7d20\u3002<\/span><\/p>\n

18. \u7f57\u6c0f\u63a7\u80a1\u7684\u65e5\u672c\u836f\u4f01\u4e2d\u5916\u5236\u836f\uff08Chugai\uff09\u8fd1\u65e5\u5ba3\u5e03\uff0c\u5df2\u5411\u65e5\u672c\u536b\u751f\u52b3\u52a8\u798f\u5229\u90e8\uff08MHLW\uff09\u63d0\u4ea4\u4e86ROS1\/TRK\u6291\u5236\u5242entrectinib\u6cbb\u7597NTRK\u878d\u5408\u9633\u6027\u5b9e\u4f53\u7624\u7684\u65b0\u836f\u7533\u8bf7\uff08NDA\uff09\u3002<\/span><\/p>\n

19. \u6fb3\u5927\u5229\u4e9a\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u65b0\u7597\u6cd5\u5c06\u5c55\u5f00\u4e34\u5e8a\u8bd5\u9a8c\u3002\u8fd9\u9879\u7597\u6cd5\u4f7f\u7528\u8d85\u58f0\u6ce2\u6280\u672f\u6fc0\u6d3b\u8111\u4e2d\u7684\u5c0f\u80f6\u8d28\u7ec6\u80de\uff0c\u4ee5\u6e05\u9664\u60a3\u8005\u8111\u90e8\u7684\u6dc0\u7c89\u6837\u86cb\u767d\u6591\u5757\u3002<\/span><\/p>\n

\u56fd\u5185\u836f\u7269\u7814\u53d1\u52a8\u6001<\/span><\/strong><\/span><\/p>\n

1. \u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6709\u6761\u4ef6\u6279\u51c6\u9996\u4e2a\u56fd\u4ea7PD-1\u5355\u6297\u2014\u2014\u7279\u745e\u666e\u5229\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u5546\u54c1\u540d\uff1a\u62d3\u76ca\uff09\u4e0a\u5e02\u3002\u8fd9\u662f\u6211\u56fd\u4f01\u4e1a\u72ec\u7acb\u7814\u53d1\u3001\u5177\u6709\u5b8c\u5168\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684\u751f\u7269\u5236\u54c1\u521b\u65b0\u836f\u54c1\uff0c\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u6807\u51c6\u6cbb\u7597\u5931\u8d25\u540e\u7684\u5c40\u90e8\u8fdb\u5c55\u6216\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c45\u671f\uff09\"<\/p>\n

2. \u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u5e15\u59a5\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u82f1\u6587\u540d\uff1aPertuzumab Injection\uff09\u8fdb\u53e3\u6ce8\u518c\u7533\u8bf7\uff0c\u8054\u5408\u66f2\u59a5\u73e0\u5355\u6297\u548c\u5316\u7597\u7528\u4e8e\u5177\u6709\u9ad8\u590d\u53d1\u98ce\u9669\u7684\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f532\uff08HER2\uff09\u9633\u6027\u65e9\u671f\u4e73\u817a\u764c\u60a3\u8005\u7684\u8f85\u52a9\u6cbb\u7597\u3002<\/span><\/p>\n

3. \u518d\u9f0e\u533b\u836f\u7684\u5375\u5de2\u764c\u65b0\u836f\u5c3c\u62c9\u5e15\u5229\u4e0a\u5e02\u7533\u8bf7\u83b7CDE\u53d7\u7406\u3002\u5c3c\u62c9\u5e15\u5229\uff08Niraparib\uff09\u4e00\u79cd\u6bcf\u65e5\u4e00\u6b21\u7684\u53e3\u670dPARP\u6291\u5236\u5242\uff0c\u5546\u54c1\u540d\u4e3a\u5219\u4e50\uff08Zejula\uff09\uff0c\u7531Tesaro\u5f00\u53d1\u7528\u4e8e\u5375\u5de2\u764c\u548c\u4e73\u817a\u764c\u7684\u6cbb\u7597\u3002<\/span><\/p>\n

4. \u9886\u661f\u751f\u7269\u79d1\u6280\uff08\u4e0a\u6d77\uff09\u6709\u9650\u516c\u53f8\u5ba3\u5e03\u5b8c\u6210\u7531\u631a\u4fe1\u8d44\u672c\u9886\u6295\uff0cGeneral Oriental\u548c\u91d1\u6d66\u5065\u5eb7\u57fa\u91d1\u8ddf\u6295\u76843000\u4e07\u7f8e\u91d1A+\u8f6e\u878d\u8d44\u3002<\/span><\/p>\n

5. \u963f\u65af\u5229\u5eb7\u4e2d\u56fd\u5ba3\u5e03\uff0c\u7531\u963f\u65af\u5229\u5eb7\u548c\u73d0\u535a\u8fdb\u5408\u4f5c\u5f00\u53d1\u7684\u56fd\u5bb61\u7c7b\u521b\u65b0\u836f\u3001\u5168\u7403\u9996\u4e2a\u53e3\u670d\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u812f\u6c28\u9170\u7f9f\u5316\u9176\u6291\u5236\u5242\uff08HIF-PHI\uff09\u2014\u2014\u7f57\u6c99\u53f8\u4ed6\uff08\u5546\u54c1\u540d\uff1a\u7231\u745e\u5353\u00ae\uff09\u5df2\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u7684\u4e0a\u5e02\u6279\u51c6\u3002<\/span><\/p>\n

6. \u745e\u77f3\u751f\u7269\u533b\u836f\u6709\u9650\u516c\u53f8\u5ba3\u5e03\uff0c\u7f8e\u56fdFDA\u6279\u51c6\u4e86\u516c\u53f8\u7533\u62a5\u7684\u65b0\u578b\u5c0f\u5206\u5b50JAK1\u6291\u5236\u5242SHR0302\u7684\u514b\u7f57\u6069\u75c5\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u7533\u8bf7\u3002\u540c\u65f6\u8be5\u4e34\u5e8a\u7814\u7a76\u7533\u8bf7\u4e5f\u4e8e\u8fd1\u671f\u83b7\u5f97\u4e2d\u56fdNMPA\u4e34\u5e8a\u8bd5\u9a8c\u8bb8\u53ef\u3002\u6b27\u6d32\u4e34\u5e8a\u7814\u7a76\u7533\u62a5\u6b63\u5728\u8fdb\u884c\u4e2d\u3002<\/span><\/p>\n

7. \u5929\u58eb\u529b\u533b\u836f\u96c6\u56e2\u80a1\u4efd\u6709\u9650\u516c\u53f8\u53d1\u5e03\u516c\u544a\u79f0\uff0c\u4e8e\u65e5\u524d\u6536\u5230FDA\u5173\u4e8e\u5929\u58eb\u529b\u5f00\u5c55\u590d\u65b9\u4e39\u53c2\u6ef4\u4e38\uff08\u7f8e\u56fdFDA\u4e34\u5e8a\u7814\u7a76\u7533\u62a5\u4ee3\u7801\u4e3aT89\uff09\u4e34\u5e8a\u8bd5\u9a8c\u7279\u6b8a\u65b9\u6848\u5ba1\u8bc4\uff08Special Protocol Assessment\uff0c\u4ee5\u4e0b\u7b80\u79f0\u201cSPA\u201d\uff09\u7684\u6279\u51c6\u51fd\u3002FDA\u540c\u610f\u548c\u6279\u51c6\u4e86ORESA\uff08\u8bd5\u9a8c\u4ee3\u7801\uff1aT89-08-ORESA,\u4ee5\u4e0b\u7b80\u79f0\u201cORESA\u201d\uff09\u4e34\u5e8a\u8bd5\u9a8c\u65b9\u6848\u3002\u76ee\u524d\u5929\u58eb\u529b\u5c06\u6309\u7167\u6279\u51c6\u51fd\u8981\u6c42\uff0c\u5728\u7f8e\u56fd\u5730\u533a\u542f\u52a8\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u53cc\u76f2\u3001\u968f\u673a\u5bf9\u7167\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u518d\u6b21\u9a8c\u8bc1T89\u6cbb\u7597\u6162\u6027\u7a33\u5b9a\u6027\u5fc3\u7ede\u75db\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\uff0c\u4ee5\u6ee1\u8db3FDA\u5bf9T89\u6cbb\u7597\u8be5\u9002\u5e94\u75c7\u7684\u65b0\u836f\u7533\u62a5\u7684\u8981\u6c42\u3002<\/span><\/p>\n

8. \u6d77\u601d\u79d1\u533b\u836f\u96c6\u56e2\u80a1\u4efd\u6709\u9650\u516c\u53f8\u7684\u76d0\u9178\u4e59\u9170\u5de6\u5361\u5c3c\u6c40\u7247\u4e8e\u8fd1\u65e5\u6536\u5230\u56fd\u5bb6\u836f\u76d1\u5c40\u6838\u51c6\u7b7e\u53d1\u7684\u300a\u836f\u54c1\u6ce8\u518c\u6279\u4ef6\u300b\u53ca\u300a\u65b0\u836f\u8bc1\u4e66\u300b\u3002<\/span><\/p>\n

\u673a\u5236\/\u9776\u70b9\u7814\u7a76\u8fdb\u5c55<\/span><\/strong><\/span><\/p>\n

1. \u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u7f8e\u56fd\u9ebb\u7701\u603b\u533b\u9662\u3001\u65b0\u6cfd\u897f\u5dde\u7acb\u5927\u5b66\u548c\u62c9\u4ec0\u5927\u5b66\u533b\u5b66\u4e2d\u5fc3\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u5c06\u4e09\u79cd\u5148\u8fdb\u7684\u6cbb\u7597\u6076\u6027\u9ed1\u8272\u7d20\u7624\u7684\u7b56\u7565—\u5206\u5b50\u9776\u5411\u7597\u6cd5\u3001\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u548c\u4f7f\u7528\u6eb6\u7624\u75c5\u6bd2—\u7ed3\u5408\u5728\u4e00\u8d77\u53ef\u80fd\u663e\u8457\u5730\u6539\u5584\u6cbb\u7597\u7ed3\u679c\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u53d1\u8868\u57282018\u5e7412\u670812\u65e5\u7684Science Translational Medicine\u671f\u520a\u4e0a\uff0c\u8bba\u6587\u6807\u9898\u4e3a\u201cMEK inhibition enhances oncolytic virus immunotherapy through increased tumor cell killing and T cell activation\u201d\u3002<\/span><\/p>\n

\n

2. \u8fd1\u65e5\uff0cJohn Collinge\u56e2\u961f\u518d\u6b21\u53d1\u6587\uff0c\u8bc1\u5b9e\u5f15\u8d77\u963f\u5179\u6d77\u9ed8\u75c5\u7684\u03b2\u6dc0\u7c89\u6837\u86cb\u767d\u75c5\u7406\u53ef\u4ee5\u901a\u8fc7\u4e0d\u5f53\u533b\u7597\u64cd\u4f5c\u8fdb\u884c\u4eba\u9645\u4f20\u64ad\u3002\u4e3a\u4e86\u6d4b\u8bd5\u8fd9\u4e9b\u6279\u6b21\u4e2d\u7684\u03b2-\u6dc0\u7c89\u6837\u86cb\u767d\u662f\u5426\u53ef\u4ee5\u5f15\u8d77\u6dc0\u7c89\u6837\u86cb\u767d\u75c5\u7406\u5b66\uff0cJohn Collinge\u56e2\u961f\u5c06\u6837\u54c1\u76f4\u63a5\u6ce8\u5c04\u5230\u6a21\u578b\u5c0f\u9f20\u7684\u8111\u5185\u3002\u7ed3\u679c\u53d1\u73b0\uff0c\u6ce8\u5c04240\u5929\u540e\uff0c\u8fd9\u4e9b\u5c0f\u9f20\u4ea7\u751f\u4e86\u03b2\u6dc0\u7c89\u6837\u86cb\u767d\u6c89\u79ef\u548c\u5927\u8111\u6dc0\u7c89\u6837\u8840\u7ba1\u75c5\uff0c\u548c\u5f53\u5e74\u6b7b\u8005\u7c7b\u4f3c\u7684\u75c5\u7406\u7279\u5f81\u3002\u4f46\u662f\u5404\u79cd\u5bf9\u7167\u7ec4\u5c0f\u9f20\uff08\u5305\u62ec\u6ce8\u5c04\u4e86\u5f53\u524d\u4f7f\u7528\u7684\u5408\u6210\u91cd\u7ec4hGH\u7684\u5c0f\u9f20\uff09\u51e0\u4e4e\u5b8c\u5168\u6ca1\u6709\u51fa\u73b0\u8fd9\u79cd\u60c5\u51b5\u3002<\/span><\/p>\n

3. 2018\u5e7411\u6708\uff0c\u6765\u81ea\u897f\u73ed\u7259\u5723\u5730\u4e9a\u54e5\u5927\u5b66\u533b\u5b66\u9662\u7b49\u591a\u4e2a\u7814\u7a76\u673a\u6784\u7684\u5b66\u8005\u5728\u300aInternational Journal of Cancer\u300b\u4e0a\u53d1\u8868\u7814\u7a76\u6210\u679c\uff0c\u9996\u6b21\u4f7f\u7528\u6765\u81ea\u4e8e\u8f6c\u79fb\u6027TNBC\u60a3\u8005\u7684\u5faa\u73af\u80bf\u7624\u7ec6\u80de\uff08CTC\uff09\uff0c\u5efa\u7acb\u4e86\u5f02\u79cd\u79fb\u690d\u6a21\u578b\uff08CTCs derived xenografts\uff0cCDX\uff09\u3002\u901a\u8fc7\u5bf9\u6a21\u578b\u7684\u6df1\u5165\u7814\u7a76\uff0c\u53d1\u73b0WNT\u4fe1\u53f7\u4f20\u5bfc\u662f\u8be5\u80bf\u7624\u751f\u7269\u5b66\u76f8\u5173\u7684\u4e3b\u8981\u673a\u5236\uff1b\u5e76\u4e14\uff0cMELK\u7684\u8fc7\u8868\u8fbe\u4e0e\u548c\u8f83\u5dee\u7684\u60a3\u8005\u5b58\u6d3b\u7387\u76f8\u5173\u3002\u603b\u4f53\u800c\u8a00\uff0c\u8be5\u7814\u7a76\u8868\u660e\u6765\u81eaTNBC\u60a3\u8005\u7684CTC\u5177\u6709\u81f4\u7624\u6027\uff0c\u5e76\u4e14\u63d0\u793aCDX\u53ef\u4ee5\u4f5c\u4e3a\u63d0\u4f9b\u80bf\u7624\u8fdb\u5c55\u4fe1\u606f\u7684\u6709\u7528\u6a21\u578b\u3002<\/span><\/p>\n

4. \u6839\u636e\u6700\u8fd1\u4e00\u9879\u7814\u7a76\u663e\u793a\uff0c\u8840\u5438\u866b\u75c5\u611f\u67d3\u4e0e\u827e\u6ecb\u75c5\u75c5\u6bd2\u611f\u67d3\u7387\u4e0a\u5347\uff0c\u827e\u6ecb\u75c5\u6bd2\u9634\u6027\u7684\u6ccc\u5c3f\u751f\u6b96\u7cfb\u8840\u5438\u866b\u75c5\u5987\u5973\u7684\u827e\u6ecb\u75c5\u6bd2\u611f\u67d3\u548c\u827e\u6ecb\u75c5\u6bd2\u9633\u6027\u5987\u5973\u7684\u6b7b\u4ea1\u6709\u5173\u3002<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u56fd\u5916\u836f\u7269\u7814\u53d1\u52a8\u6001 1. FDA\u5ba3\u5e03\uff0c\u6279\u51c6Shire\u516c\u53f8\u6cbb\u7597\u6162\u6027\u7279\u53d1\u6027\u4fbf\u79d8\uff08CIC\uff09\u7684Motegrity\uff08pru […]<\/p>\n","protected":false},"author":1,"featured_media":78358,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/78357"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=78357"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/78357\/revisions"}],"predecessor-version":[{"id":78361,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/78357\/revisions\/78361"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/78358"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=78357"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=78357"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=78357"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}