{"id":78372,"date":"2018-12-14T00:00:50","date_gmt":"2019-02-01T06:16:33","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/78372\/"},"modified":"2019-02-01T14:16:34","modified_gmt":"2019-02-01T06:16:34","slug":"653e346981","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/78372\/","title":{"rendered":"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c44\u671f\uff09"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section class=\"\" style=\"max-width: 100%;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;display: inline-block;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"padding-right: 2em;padding-left: 2em;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding: 3px 0.6em;max-width: 100%;box-sizing: border-box;color: rgb(255, 255, 255);letter-spacing: 1.5px;background: rgb(91, 193, 202);word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u56fd\u5916\u836f\u7269\u7814\u53d1\u52a8\u6001<\/span><\/section>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;border-bottom: 1px solid rgb(91, 193, 202);word-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-top: 10px;margin-bottom: 20px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);letter-spacing: 0.544px;text-align: justify;white-space: normal;font-family: sans-serif;font-size: 14px;line-height: 2;background-color: rgb(255, 255, 255);text-indent: 2em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"color: rgb(62, 52, 52);font-size: 15px;text-indent: 2em;\">1.\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\uff08BMS\uff09\u548cVedanta Biosciences\u5171\u540c\u5ba3\u5e03\uff0c\u53cc\u65b9\u5c06\u5f00\u5c55\u4e00\u9879\u4e34\u5e8a\u8bd5\u9a8c\u5408\u4f5c\uff0c\u8bc4\u4f30\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u7684PD-1\u514d\u75ab\u68c0\u67e5\u70b9\u836f\u7269Opdivo\u4e0eVedanta\u7684\u5fae\u751f\u7269\u7ec4\u5019\u9009\u836f\u7269VE800\u8054\u5408\u4f7f\u7528\uff0c\u7528\u4e8e\u6cbb\u7597\u665a\u671f\u6216\u8f6c\u79fb\u6027\u764c\u75c7\u7684\u7597\u6548\u3002\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u8fd8\u8ba1\u5212\u5bf9Vedanta\u8fdb\u884c\u8d22\u52a1\u6295\u8d44\u3002<\/span><br  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">2. Axovant\u5ba3\u5e03\u4eceArena\u6536\u8d2d\u76845HT2A\u53cd\u5411\u6fc0\u52a8\u5242nelotanserin\u5728\u4e00\u4e2a\u53eb\u505a\u8def\u6613\u6c0f\u4f53\u8ba4\u77e5\u969c\u788d\u75c7(LBD)\u60a3\u8005\u7761\u7720\u969c\u788d\uff08RBD\uff09\u7684\u4e8c\u671f\u4e34\u5e8a\u8bd5\u9a8c\u672a\u80fd\u8fbe\u5230\u8bd5\u9a8c\u7ec8\u70b9\u3002\u8fd9\u4e2a\u8bd5\u9a8c\u62db\u52df34\u4f4d\u60a3\u8005\uff0c\u4e00\u7ea7\u7ec8\u70b9\u662fRBD\u9891\u7387\u3002\u53d7\u6b64\u6d88\u606f\u5f71\u54cd\u4eca\u5929AXON\u4e0b\u6ed128%\uff0cAXON\u540c\u65f6\u5ba3\u5e03\u5c06\u505c\u6b62\u5c0f\u5206\u5b50\u836f\u7269\u5f00\u53d1\u800c\u96c6\u4e2d\u7cbe\u529b\u5f00\u53d1\u57fa\u56e0\u7597\u6cd5\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">3. Entera Bio\u5ba3\u5e03\u5df2\u4e0e\u5b89\u8fdb\uff08Amgen\uff09\u5728\u708e\u75c7\u6027\u75be\u75c5\u548c\u5176\u5b83\u4e25\u91cd\u75be\u75c5\u9886\u57df\u8fbe\u6210\u4e00\u9879\u7814\u7a76\u5408\u4f5c\u53ca\u8bb8\u53ef\u534f\u8bae\uff0cEntera\u5c06\u4f7f\u7528\u5176\u72ec\u6709\u7684\u5927\u5206\u5b50\u836f\u7269\u53e3\u670d\u9012\u9001\u5e73\u53f0\u4e3a\u5b89\u8fdb\u5f00\u53d1\u4e00\u6b3e\u53e3\u670d\u5927\u5206\u5b50\u751f\u7269\u5236\u5242\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">4. PharmaMar\u8fd1\u65e5\u5ba3\u5e03\uff0c\u6fb3\u5927\u5229\u4e9a\u836f\u54c1\u7ba1\u7406\u5c40\uff08TGA\uff09\u5df2\u6279\u51c6\u836f\u7269Aplidin\uff08plitidepsin\uff09\uff0c\u8054\u5408\u5730\u585e\u7c73\u677e\u7528\u4e8e\u5bf9\u5176\u4ed6\u7597\u6cd5\u6cbb\u7597\u5931\u8d25\u6216\u6709\u62b5\u6297\u7684\u590d\u53d1\u6027\u6216\u96be\u6cbb\u6027\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\uff08MM\uff09\u60a3\u8005\u7684\u6cbb\u7597\u3002Plitidepsin\u662f\u4e00\u79cd\u6d77\u6d0b\u6765\u6e90\u7684\u9996\u521b\uff08first-in-class\uff09\u6297\u764c\u836f\u7269\uff0c\u6700\u521d\u662f\u4ece\u4e00\u79cd\u539f\u7d22\u52a8\u7269\u2014\u2014\u5730\u4e2d\u6d77\u6d77\u9798\uff08Aplidiumalbicans\uff09\u4e2d\u83b7\u5f97\u7684\uff0c\u80fd\u591f\u7279\u5f02\u6027\u5730\u4e0e\u771f\u6838\u7ffb\u8bd1\u5ef6\u957f\u56e0\u5b501A2\uff08eEF1A2\uff09\u7ed3\u5408\uff0c\u5e76\u9776\u5411\u8be5\u86cb\u767d\u7684\u975e\u5178\u578b\u4f5c\u7528\uff0c\u901a\u8fc7\u7ec6\u80de\u51cb\u4ea1\uff08\u7a0b\u5e8f\u6027\u6b7b\u4ea1\uff09\u5bfc\u81f4\u80bf\u7624\u7ec6\u80de\u6b7b\u4ea1\u3002\u76ee\u524d\uff0c\u8be5\u836f\u7269\u6b63\u5904\u4e8e\u4e34\u5e8a\u5f00\u53d1\u7528\u4e8e\u591a\u79cd\u8840\u6db2\u5b66\u80bf\u7624\u7684\u6cbb\u7597\uff0c\u5305\u62ec\u6cbb\u7597\u590d\u53d1\u6027\u6216\u96be\u6cbb\u6027MM\u7684\u7ec4\u5408\u7814\u7a76\uff0c\u4ee5\u53ca\u6cbb\u7597\u590d\u53d1\u6027\u6216\u96be\u6cbb\u6027\u8840\u7ba1\u514d\u75ab\u6bcd\u7ec6\u80de\u6027T\u7ec6\u80de\u6dcb\u5df4\u7624\u7684II\u671f\u7814\u7a76\u3002<\/span><\/p>\n<p style=\"text-align: center;margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);\"><img loading=\"lazy\" class=\"\"     height=\"165\" style=\"border-width: 0px;border-style: initial;border-color: initial;\" title=\"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c44\u671f\uff09\" width=\"400\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/8-1549001794.jpeg\" alt=\"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c44\u671f\uff09\"  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">&nbsp;<\/span><span style=\"color: rgb(62, 52, 52);font-size: 15px;text-indent: 2em;\">5.\u7f8e\u56fdFDA\u5c40\u957f\u4e8e\u7f8e\u56fd\u5f53\u5730\u65f6\u95f4\u5468\u4e8c\uff0812\u670811\u65e5\uff09\u53d1\u5e03\u4e86\u63a8\u8fdb\u8be5\u673a\u6784\u751f\u7269\u4eff\u5236\u836f\u653f\u7b56\u6846\u67b6\u65b0\u4e3e\u63aa\u7684\u58f0\u660e\u3002FDA\u53d1\u5e03\u4e86\u56db\u4efd\u65b0\u7684\u6307\u5bfc\u6587\u4ef6\uff0c\u5305\u62ec\u4e24\u4efd\u5173\u4e8e\u751f\u7269\u4eff\u5236\u836f\u5f00\u53d1\u7684\u65b0\u95ee\u7b54\u6307\u5357\u6587\u4ef6\u4ee5\u53ca\u4e24\u4efd\u5173\u4e8e\u4fee\u6539\u751f\u7269\u4ea7\u54c1\u5b9a\u4e49\u7684\u6700\u7ec8\u6307\u5bfc\u6587\u4ef6\uff0c\u8fd9\u4e9b\u65b0\u4e3e\u63aa\u4e3a\u751f\u7269\u4eff\u5236\u836f\u548c\u53ef\u4e92\u6362\u4ea7\u54c1\uff08interchangeable products\uff09\u7684\u5f00\u53d1\u63d0\u4f9b\u4e86\u66f4\u6e05\u6670\u7684\u79d1\u5b66\u548c\u6cd5\u89c4\u8003\u8651\u56e0\u7d20\u3002FDA\u8868\u793a\uff0c\u5c06\u8ba1\u5212\u5b9a\u671f\u66f4\u65b0\u8fd9\u4e9b\u65b0\u7684\u6307\u5bfc\u6587\u4ef6\uff0c\u4ee5\u89e3\u51b3\u53d1\u5c55\u8fc7\u7a0b\u4e2d\u9047\u5230\u7684\u65b0\u95ee\u9898\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">6. AC Immune\u516c\u53f812\u670812\u65e5\u65e9\u4e0a\u62ab\u9732\uff0c\u4e0e\u793c\u6765\u8fbe\u6210\u4e86\u65b0\u7684\u5408\u4f5c\uff0c\u83b7\u5f978000\u4e07\u745e\u58eb\u6cd5\u90ce\u9996\u4ed8\u6b3e\uff0c6000\u4e07\u745e\u58eb\u6cd5\u90ce\u4e2d\u671f\u91cc\u7a0b\u91d1\uff0c\u5176\u4ed617\u4ebf\u7f8e\u5143\u7684\u7814\u53d1\u3001\u6ce8\u518c\u53ca\u4e0a\u5e02\u91cc\u7a0b\u91d1\u3002\u4ea7\u54c1\u4e0a\u5e02\u540e\uff0cAC Immune\u53ef\u83b7\u5f97\u4f4e\u53cc\u4f4d\u6570\u7684\u9500\u552e\u5206\u6210\u3002\u793c\u6765\u8fd9\u6b21\u4e0eAC Immune\u516c\u53f8\u5408\u4f5c\u5f00\u53d1\u7684\u6838\u5fc3\u8d44\u4ea7\u662f\u4e00\u6b3e\u4ee3\u53f7\u4e3aACI-3024\u7684\u836f\u7269\uff0c\u5904\u4e8e\u4e34\u5e8a\u524d\u9636\u6bb5\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">7.\u6768\u68ee\u516c\u53f8\u5ba3\u5e03\u4e86Tremfya\uff08guselkumab\uff09\u4e0eCosentyx\uff08secukinumab\uff09\u7528\u4e8e\u6cbb\u7597\u4e2d\u91cd\u5ea6\u6591\u5757\u72b6\u94f6\u5c51\u75c5\u7684\u5934\u5bf9\u5934PKECLIPSE III\u671f\u7814\u7a76\u768448\u5468\u7ed3\u679c\u3002Tremfya\u6cbb\u7597\u7ec4\u60a3\u8005\u94f6\u5c51\u75c5\u9762\u79ef\u548c\u4e25\u91cd\u6307\u6570\u8f83\u57fa\u7ebf\u6539\u558490%\u4ee5\u4e0a\uff08PASI 90\uff0c\u4e3b\u8981\u7ec8\u70b9\uff09\u7684\u60a3\u8005\u6bd4\u4f8b\u662f84.5%\uff0c\u800cCosentyx\u6cbb\u7597\u7ec4\u4e3a70%\uff0cTremfya\u4f18\u4e8eCosentyx\u3002\u8be5\u7814\u7a76\u7684\u8be6\u7ec6\u7ed3\u679c\u5c06\u4e8e12-15\u65e5\u5728\u7b2c3\u5c4a\u708e\u75c7\u6027\u76ae\u80a4\u75be\u75c5\u9ad8\u5cf0\u8bba\u575b\u4e0a\u516c\u5e03\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">8. GenSight Biologics\u516c\u53f8\u5ba3\u5e03\uff0c\u8be5\u516c\u53f8\u7684\u57fa\u56e0\u7597\u6cd5GS010\uff0c\u5728\u6cbb\u7597Leber\u9057\u4f20\u6027\u89c6\u795e\u7ecf\u75c5\u53d8\uff08LHON\uff09\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8868\u73b0\u51fa\u79ef\u6781\u7684\u957f\u671f\u7597\u6548\u3002\u5728\u63a5\u53d7\u6cbb\u759772\u5468\u4e4b\u540e\uff0c\u4fdd\u6301\u5bf9\u60a3\u8005\u4e0e\u89c6\u89c9\u76f8\u5173\u751f\u6d3b\u8d28\u91cf\u7684\u6301\u7eed\u6539\u5584\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">9.\u8bfa\u534e\uff08Novartis\uff09\u8fd1\u65e5\u516c\u5e03\u4e86\u65b0\u578b\u4e73\u817a\u764c\u9776\u5411\u836f\u7269Kisqali\uff08ribociclib\uff093\u9879\u5173\u952e\u6027III\u671fMONALEESA\u7814\u7a76\u7684\u4e9a\u7ec4\u5206\u6790\u6570\u636e\u3002\u6570\u636e\u663e\u793a\uff0c\u5728\u7edd\u7ecf\u524d\u3001\u56f4\u7edd\u7ecf\u671f\u3001\u7edd\u7ecf\u540e\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\u3001\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f532\u9634\u6027\uff08HR+\/HER2-\uff09\u665a\u671f\u4e73\u817a\u764c\u60a3\u8005\u4e2d\uff0c\u5728\u4e0e\u5185\u5206\u6ccc\u5355\u72ec\u6cbb\u7597\u76f8\u6bd4\uff0cKisqali\u8054\u5408\u5185\u5206\u6ccc\u6cbb\u7597\u663e\u8457\u5ef6\u957f\u4e86\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\uff0c\u4e0d\u8bba\u60a3\u8005\u662f\u5426\u5b58\u5728\u5185\u810f\u8f6c\u79fb\u3002<\/span><\/p>\n<section class=\"\" style=\"max-width: 100%;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;display: inline-block;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"padding-right: 2em;padding-left: 2em;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding: 3px 0.6em;max-width: 100%;box-sizing: border-box;color: rgb(255, 255, 255);letter-spacing: 1.5px;background: rgb(91, 193, 202);word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u56fd\u5185\u836f\u7269\u7814\u53d1\u52a8\u6001<\/span><\/section>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;border-bottom: 1px solid rgb(91, 193, 202);word-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-top: 10px;margin-bottom: 20px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);letter-spacing: 0.544px;text-align: justify;white-space: normal;font-family: sans-serif;font-size: 14px;line-height: 2;background-color: rgb(255, 255, 255);text-indent: 2em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"color: rgb(62, 52, 52);font-size: 15px;text-indent: 2em;\">1.\u836f\u660e\u751f\u7269\u4e0e\u65b0\u9510\u751f\u7269\u6280\u672f\u516c\u53f8\u817e\u76db\u535a\u836f\uff08Brii Biosciences\uff09\u9488\u5bf9\u6cbb\u7597\u4f20\u67d3\u75c5\u53ca\u514d\u75ab\u75be\u75c5\u7684\u5168\u65b0\u53cc\u7279\u5f02\u6027\u6297\u4f53\u7814\u53d1\u8fbe\u6210\u6218\u7565\u5408\u4f5c\uff0c\u5e76\u6210\u4e3a\u8fd9\u4e9b\u9879\u76ee\u7684\u72ec\u5bb6\u5de5\u827a\u5f00\u53d1\u548c\u751f\u4ea7\u5408\u4f5c\u4f19\u4f34\uff0c\u4e3a\u817e\u76db\u535a\u836f\u63d0\u4f9b\u5f3a\u6709\u529b\u652f\u6301\u3002<\/span><br  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">2.\u5409\u5229\u5fb7\uff08Gilead\uff09\u8fd1\u65e5\u5ba3\u5e03\uff0c\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u5df2\u6279\u51c6HIV\u590d\u65b9\u65b0\u836fDescovy\uff08\u8fbe\u53ef\u6325\uff0cF\/TAF\uff0c\u6069\u66f2\u4ed6\u6ee8\/\u4e19\u915a\u66ff\u8bfa\u798f\u97e6\uff0c200\/10mg\u548c200\/25mg\uff09\uff0c\u8054\u5408\u5176\u4ed6\u6297\u9006\u8f6c\u5f55\u75c5\u6bd2\u836f\u7269\uff0c\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u548c\u9752\u5c11\u5e74\uff08\u5e74\u9f84\u226512\u5c81\uff0c\u4f53\u91cd\u226535kg\uff09\u7684HIV-1\u611f\u67d3\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">3.\u666f\u5cf0\u533b\u836f\u4e8e10\u300111\u65e5\u53d1\u5e03\u516c\u544a\u79f0\uff0c\u516c\u53f8\u5b89\u975e\u4ed6\u547d\u6df7\u5408\u76d0\u3001\u6cfc\u5c3c\u677e\u7247\u5df2\u83b7\u5f97\u7f8e\u56fdFDA\u65b0\u836f\u7b80\u7565\u7533\u8bf7\uff0c\u8fd9\u610f\u5473\u7740\u666f\u5cf0\u533b\u836f\u53ef\u4ee5\u751f\u4ea7\u5e76\u5728\u7f8e\u56fd\u5e02\u573a\u9500\u552e\u8be5\u4ea7\u54c1\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">4.\u6df1\u5733\u7ff0\u5b87\u836f\u4e1a\u53d1\u5e03\u516c\u544a\u79f0\u8fd1\u65e5\u6536\u5230\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08\u4ee5\u4e0b\u7b80\u79f0\u201c\u56fd\u5bb6\u836f\u76d1\u5c40\u201d\uff09\u4e0b\u53d1\u7684\u5173\u4e8e\u6ce8\u5c04\u7528\u918b\u9178\u897f\u66f2\u745e\u514b\u300a\u836f\u54c1\u6ce8\u518c\u6279\u4ef6\u300b\u3002\u897f\u66f2\u745e\u514b\u662f\u4e00\u79cd\u4eba\u5de5\u5408\u6210\u7684\u4fc3\u6027\u817a\u6fc0\u7d20\u91ca\u653e\u6fc0\u7d20\uff08GnRH\uff09\u62ee\u6297\u5242\uff08GnRH-A\uff09\u836f\u7269\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">5. 12\u670811\u65e5\uff0c\u957f\u751f\u751f\u7269\u53d1\u5e03\u516c\u544a\uff0c\u660e\u786e\u6df1\u4ea4\u6240\u62df\u5bf9\u516c\u53f8\u80a1\u7968\u5b9e\u65bd\u91cd\u5927\u8fdd\u6cd5\u5f3a\u5236\u9000\u5e02\u3002<\/span><\/p>\n<p style=\"text-align: center;margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);\"><img class=\"\"     style=\"border-width: 0px;border-style: initial;border-color: initial;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/0-1549001794.jpeg\" alt=\"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c44\u671f\uff09\" title=\"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c44\u671f\uff09\"  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">6.\u518d\u9f0e\u533b\u836f\u5ba3\u5e03\uff0c\u9999\u6e2f\u9996\u4e2a\u83b7\u6279\u7528\u4e8e\u6240\u6709\u94c2\u654f\u611f\u590d\u53d1\u5375\u5de2\u764c\u60a3\u8005\u7ef4\u6301\u6cbb\u7597\uff0c\u800c\u65e0\u8bbaBRCA\u662f\u5426\u7a81\u53d8\u7684PARP\u6291\u5236\u5242\u2014\u2014\u5219\u4e50\u00ae\uff08\u5c3c\u62c9\u5e15\u5229\uff0cZL-2306\uff09\u4eca\u65e5\u6b63\u5f0f\u4e0a\u5e02\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">7.\u7eff\u53f6\u5236\u836f\u96c6\u56e2\u5ba3\u5e03\uff0c\u5176\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u5728\u7814\u65b0\u836f&#8211;\u6ce8\u5c04\u7528\u7f57\u66ff\u6208\u6c40\u7f13\u91ca\u5fae\u7403\uff08LY03003\uff09\u5df2\u5411\u65e5\u672c\u72ec\u7acb\u884c\u653f\u6cd5\u4eba\u533b\u836f\u54c1\u53ca\u533b\u7597\u5668\u68b0\u7efc\u5408\u7ba1\u7406\u673a\u6784\uff08PMDA\uff09\u7533\u62a5\u4e34\u5e8a\u8bd5\u9a8c\u6279\u4ef6\uff0c\u5373\u5c06\u5728\u65e5\u672c\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\u3002\u6b64\u5916\uff0cLY03003\u5df2\u5728\u4e2d\u3001\u7f8e\u4e24\u56fd\u5206\u522b\u8fdb\u5165III\u671f\u4e34\u5e8a\uff0c\u76ee\u524d\u8fdb\u5c55\u987a\u5229\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">8.\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u53f8\u6765\u5e15\u683c\u7247\uff08\u82f1\u6587\u540d\uff1aSelexipag Tablets\uff09\u8fdb\u53e3\u6ce8\u518c\u7533\u8bf7\uff0c\u7528\u4e8e\u6cbb\u7597\u80ba\u52a8\u8109\u9ad8\u538b\u3002\u53f8\u6765\u5e15\u683c\u7247\u662f\u4e00\u79cd\u53e3\u670d\u6709\u6548\u3001\u9ad8\u9009\u62e9\u6027\u548c\u957f\u6548\u7684\u975e\u524d\u5217\u817a\u7d20\u7c7b\u524d\u5217\u73af\u7d20\u53d7\u4f53\uff08IP\u53d7\u4f53\uff09\u6fc0\u52a8\u5242\uff0c\u53ef\u6539\u5584\u635f\u4f24\u7684\u80ba\u52a8\u8109\u5185\u76ae\u4f9d\u8d56\u6027\u8212\u5f20\uff0c\u5e76\u53ef\u80fd\u6291\u5236\u4eba\u80ba\u5e73\u6ed1\u808c\u7ec6\u80de\u7684\u589e\u6b96\u3001\u80ba\u8840\u7ba1\u58c1\u7684\u589e\u539a\u3002\u4e0e\u5df2\u7ecf\u4e0a\u5e02\u7684\u7528\u4e8e\u6cbb\u7597\u80ba\u52a8\u8109\u9ad8\u538b\u7684\u524d\u5217\u73af\u7d20\u7c7b\u836f\u7269\u6bd4\u8f83\uff0c\u672c\u54c1\u662f\u9996\u4e2a\u53ef\u4ee5\u53e3\u670d\u7684\u5236\u5242\uff0c\u53ef\u6539\u5584\u60a3\u8005\u7684\u4f9d\u4ece\u6027\u3002<\/span><\/p>\n<section class=\"\" style=\"max-width: 100%;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"max-width: 100%;display: inline-block;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"padding-right: 2em;padding-left: 2em;max-width: 100%;box-sizing: border-box;word-wrap: break-word !important;\">\n<section style=\"padding: 3px 0.6em;max-width: 100%;box-sizing: border-box;color: rgb(255, 255, 255);letter-spacing: 1.5px;background: rgb(91, 193, 202);word-wrap: break-word !important;\">\u673a\u5236\/\u9776\u70b9\u7814\u7a76\u8fdb\u5c55<\/section>\n<\/section>\n<section style=\"max-width: 100%;box-sizing: border-box;border-bottom: 1px solid rgb(91, 193, 202);word-wrap: break-word !important;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin-top: 10px;margin-bottom: 20px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);letter-spacing: 0.544px;text-align: justify;white-space: normal;font-family: sans-serif;font-size: 14px;line-height: 2;background-color: rgb(255, 255, 255);text-indent: 2em;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"color: rgb(62, 52, 52);font-size: 15px;text-indent: 2em;\">1.\u8fd1\u65e5\uff0c\u4e00\u9879\u520a\u767b\u5728\u56fd\u9645\u6742\u5fd7Nature Immunology\u4e0a\u7684\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u963f\u62c9\u5df4\u9a6c\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u7814\u7a76\u6307\u51fa\u4e86\u4e00\u79cd\u5f00\u53d1\u65b0\u578b\u6709\u6548\u6d41\u611f\u75ab\u82d7\u7684\u65b0\u7b56\u7565\u3002\u6587\u7ae0\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u5bf9\u80ba\u90e8\u4e2d\u7684\u56fa\u6709\u8bb0\u5fc6B\u7ec6\u80de\u8fdb\u884c\u7814\u7a76\uff0c\u4ed6\u4eec\u5e0c\u671b\u80fd\u5229\u7528\u8fd9\u79cd\u7ec6\u80de\u4fe9\u5e2e\u52a9\u5f00\u53d1\u62b5\u5fa1\u6d41\u611f\u75c5\u6bd2\u611f\u67d3\u7684\u65b0\u578b\u7b56\u7565\u3002<\/span><br  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">2.\u4e00\u9879\u520a\u767b\u5728\u56fd\u9645\u6742\u5fd7Nature Genetics\u4e0a\u7684\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u54c8\u4f5b\u533b\u5b66\u9662\u7b49\u673a\u6784\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u7814\u7a76\u63ed\u793a\u4e86DNA\u635f\u4f24\u5f71\u54cd\u7a81\u53d8\u53d1\u751f\u7684\u5206\u5b50\u673a\u5236\uff0c\u7814\u7a76\u8005\u8868\u793a\uff0c\u6211\u4eec\u5bf9\u7a81\u53d8\u5f62\u6210\u7684\u8d21\u732e\u6216\u8bb8\u8fdc\u8fdc\u88ab\u4f4e\u4f30\u4e86\uff0c\u5f88\u591a\u9057\u4f20\u7a81\u53d8\u6216\u8bb8\u5e76\u4e0d\u662f\u7531DNA\u7684\u52a0\u500d\u9519\u8bef\u6240\u5f15\u8d77\u7684\uff0c\u800c\u662f\u7531\u8106\u5f31\u5206\u5b50\u6240\u5bfc\u81f4\u7684\u635f\u4f24\u5f15\u8d77\u7684\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(62, 52, 52);\">3.\u300a\u81ea\u7136\u300b\u5b50\u520a\u300a\u81ea\u7136\u00b7\u7eb3\u7c73\u6280\u672f\u300b\uff08Nature Nanotechnology\uff09\u5728\u7ebf\u520a\u767b\u4e86\u4e00\u9879\u521b\u65b0\u6297\u764c\u7814\u7a76\uff1a\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\uff08UCLA\uff09\u534e\u4eba\u5b66\u8005\u987e\u81fb\u6559\u6388\u4e0e\u5176\u56e2\u961f\u5f00\u53d1\u51fa\u4e86\u4e00\u79cd\u65b0\u578b\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7b56\u7565\u3002\u901a\u8fc7\u5728\u80bf\u7624\u5207\u9664\u90e8\u4f4d\u55b7\u6d12\u55b7\u96fe\uff0c\u5feb\u901f\u5f62\u6210\u51dd\u80f6\uff0c\u5e76\u901a\u8fc7\u5305\u57cb\u5176\u4e2d\u7684\u7eb3\u7c73\u9897\u7c92\u7f13\u91ca\u6297\u4f53\u836f\u7269\uff0c\u7814\u7a76\u4eba\u5458\u5728\u52a8\u7269\u6a21\u578b\u4e0a\u9a8c\u8bc1\u4e86\u8be5\u79cd\u55b7\u5242\u80fd\u9776\u5411\u624b\u672f\u540e\u7684\u6b8b\u4f59\u764c\u7ec6\u80de\uff0c\u663e\u8457\u6291\u5236\u764c\u75c7\u590d\u53d1\u548c\u6f5c\u5728\u7684\u8f6c\u79fb\u3002<\/span><\/p>\n<p style=\"text-align: center;margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);\">\n<p style=\"margin-top: 10px;margin-bottom: 20px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);letter-spacing: 0.544px;text-align: justify;white-space: normal;font-family: sans-serif;font-size: 14px;line-height: 2;background-color: rgb(255, 255, 255);text-indent: 2em;box-sizing: border-box !important;word-wrap: break-word !important;\"><br  \/><\/p>\n<section class=\"\" style=\"max-width: 100%;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word 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