{"id":78380,"date":"2018-12-12T00:00:50","date_gmt":"2019-02-01T06:16:40","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/78380\/"},"modified":"2019-02-01T14:16:46","modified_gmt":"2019-02-01T06:16:46","slug":"9c8ac172e5","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/78380\/","title":{"rendered":"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.10.15~11.14\uff09"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;\">\u3010\u7f16\u8005\u6309\u3011\uff1a\u672c\u6587\u5bf9Thomson Reuters Integrity\u6570\u636e\u5e93\u6536\u5f55\u7684\u4e8e2018\u5e7410\u670815\u65e5\uff5e2018\u5e7411\u670814\u65e5\u671f\u95f4\u516c\u5f00\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\u8fdb\u884c\u4e86\u68b3\u7406\uff0c\u5e76\u91cd\u70b9\u5206\u6790\u4e86\u7533\u8bf7\u6570\u91cf\u6392\u540d\u524d3\u7684\u516c\u53f8\uff08Novintum Biotechnology\u3001\u8bfa\u534e\u548c\u7f57\u6c0f\uff09\u4ee5\u53ca\u5176\u4ed6\u56fd\u5916\u836f\u4f01\u548c\u90e8\u5206\u56fd\u5185\u836f\u4f01\/\u79d1\u7814\u673a\u6784\u7684\u4e13\u5229\u7533\u8bf7\u72b6\u51b5\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"background-color: rgb(255, 255, 255);font-size: 15px;color: rgb(61, 167, 66);\"><strong>\u603b\u89c8<\/strong><\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;\">\u636eThomson Reuters Integrity\u6570\u636e\u5e93\uff08\u68c0\u7d22\u65e5\u671f\uff1a2018\u5e7411\u670827\u65e5\uff09\u663e\u793a\uff0c2018\u5e7410\u670815\u65e5\u81f311\u670814\u65e5\u671f\u95f4\uff0c\u5168\u7403\u516c\u5f00\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\uff08Drug Substances\uff09\u4e13\u5229\u7533\u8bf7\u5171185\u4ef6\uff0c\u5176\u6309\u75be\u75c5\u9886\u57df\u5206\u7c7b\u65f6\uff0c\u6d89\u53ca\u764c\u75c7\u7684\u6700\u591a\uff0c\u5176\u6b21\u4ee5\u611f\u67d3\u3001\u708e\u75c7\u3001\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u4e3a\u4e3b\uff08\u56fe1\uff09\uff1b\u800c\u5728\u4f5c\u7528\u673a\u5236\u65b9\u9762\uff0c\u4e3b\u8981\u4ee5\u4fe1\u53f7\u8f6c\u5bfc\u8c03\u8282\u5242\u4e3a\u4e3b\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-align: justify;\"><img loading=\"lazy\" align=\"\" class=\"\"     height=\"429\" style=\"border-width: 0px;border-style: initial;border-color: initial;\" title=\"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.10.15~11.14\uff09\" width=\"500\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/2-1549001801.jpg\" alt=\"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.10.15~11.14\uff09\"  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"background-color: rgb(255, 255, 255);font-size: 15px;color: rgb(61, 167, 66);\"><strong>\u56fd\u5916\u836f\u4f01\u5206\u6790<\/strong><\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;\">\u5728\u68c0\u7d22\u65f6\u95f4\u8303\u56f4\u5185\uff0c\u6709\u4f17\u591a\u56fd\u5916\u836f\u4f01\u7684\u4e13\u5229\u7533\u8bf7\u88ab\u516c\u5f00\uff0c\u4ee5\u4e0b\u5bf9\u7533\u8bf7\u6570\u91cf\u6392\u540d\u524d3\u7684\u836f\u4f01\uff08Novintum Biotechnology\u3001\u8bfa\u534e\u548c\u7f57\u6c0f\uff09\u4e13\u5229\u8fdb\u884c\u8be6\u7ec6\u5206\u6790\uff0c\u540c\u65f6\uff0c\u4e5f\u5bf9\u5176\u4ed6\u836f\u4f01\u7684\u4e00\u4e9b\u4e13\u5229\u7533\u8bf7\u60c5\u51b5\u8fdb\u884c\u4e86\u6982\u8ff0\uff08\u88684\uff09\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"background-color: rgb(255, 255, 255);font-size: 15px;color: rgb(61, 167, 66);\"><strong>Novintum&nbsp;Biotechnology<\/strong><\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;\">\u5728\u68c0\u7d22\u65f6\u95f4\u8303\u56f4\u5185\uff0c\u65b0\u5174\u516c\u53f8Novintum Biotechnology\u516c\u5f00\u4e868\u4ef6\u4e13\u5229\u7533\u8bf7\uff08\u88681\uff09\uff0c\u4e14\u9002\u5e94\u75c7\u96c6\u4e2d\u5728\u764c\u75c7\uff086\u4ef6\uff09\u548c\u611f\u67d3\uff082\u4ef6\uff09\u65b9\u9762\uff0c\u5176\u4e2d\uff0c\u67096\u4ef6\u6d89\u53ca\u963f\u5947\u9709\u7d20\u884d\u751f\u7269\uff08WO 2018193111\u3001WO 2018193116\u3001WO 2018193117\u3001WO 2018193125\u3001WO 2018193126\u548cWO 2018193124\uff09\uff0c2\u4ef6\uff08WO 2018193113\u548cWO 2018193114\uff09\u6d89\u53ca\u56db\u73af\u7d20\u884d\u751f\u7269\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-align: justify;\"><img loading=\"lazy\" align=\"\" class=\"\"     height=\"572\" style=\"border-width: 0px;border-style: initial;border-color: initial;\" title=\"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.10.15~11.14\uff09\" width=\"650\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/3-1549001801.jpg\" alt=\"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.10.15~11.14\uff09\"  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-align: justify;\"><img loading=\"lazy\" align=\"\" class=\"\"     height=\"339\" style=\"border-width: 0px;border-style: initial;border-color: initial;\" title=\"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.10.15~11.14\uff09\" width=\"650\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/4-1549001802.jpg\" alt=\"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.10.15~11.14\uff09\"  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(61, 167, 66);\"><strong>\u8bfa\u534e<\/strong><\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;\">\u5728\u68c0\u7d22\u65f6\u95f4\u8303\u56f4\u5185\uff0c\u8bfa\u534e\u516c\u5e03\u4e865\u4ef6\u4e13\u5229\u7533\u8bf7\uff08\u88682\uff09\uff1a1\uff09\u6d89\u53ca\u611f\u67d3\u76843\u4ef6\u4e13\u5229\u7533\u8bf7\uff08WO 2018203302\u3001WO 2018198076\u548cWO 2018198079\uff09\uff0c\u5206\u522b\u516c\u5f00\u4e86\u4e09\u73af2-\u55b9\u5549\u916e\u7c7b\u7269\u8d28\u3001\u73af\u72b6\u4e8c\u6838\u82f7\u9178\u548c\u56db\u73af\u5421\u5576\u916e\u7c7b\u7269\u8d28\uff0c\u4e14\u4f5c\u7528\u673a\u5236\u5404\u4e0d\u76f8\u540c\uff1b2\uff09\u7528\u4e8e\u764c\u75c7\u76842\u4ef6\u4e13\u5229\u7533\u8bf7\u4e2d\uff0cWO 2018198076\u4e2d\u7684\u5316\u5408\u7269\u4f5c\u7528\u673a\u5236\u5c5e\u4e8e\u5e72\u6270\u7d20\u57fa\u56e0\u86cb\u767d\uff08STING\u3001TMEM173\uff09\u6fc0\u52a8\u5242\u7684\u523a\u6fc0\u5242\uff0c\u800cWO 2018200812\u4e2d\u7684\u5316\u5408\u7269\u5c5e\u4e8e\u5305\u542bSTING\u6fc0\u52a8\u5242\u7684\u514d\u75ab\u5076\u8054\u7269\uff1b3\uff09\u7528\u4e8e\u773c\u79d1\u75be\u75c5\u76841\u4ef6\uff08WO 2018198077\uff09\u4e13\u5229\u7533\u8bf7\u516c\u5f00\u4e866-6\u7a20\u5408\u53cc\u73af\u6742\u82b3\u57fa\u5316\u5408\u7269\u7c7b\u7269\u8d28\uff0c\u4e14\u4f5c\u7528\u673a\u5236\u5c5e\u4e8eLATS\uff08Large tumor suppressor kinase\uff09\u6291\u5236\u5242\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-align: justify;\"><img loading=\"lazy\" align=\"\" class=\"\"     height=\"500\" style=\"border-width: 0px;border-style: initial;border-color: initial;\" title=\"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.10.15~11.14\uff09\" width=\"650\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/4-1549001803.jpg\" alt=\"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.10.15~11.14\uff09\"  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-align: justify;\"><img loading=\"lazy\" align=\"\" class=\"\"     height=\"241\" style=\"border-width: 0px;border-style: initial;border-color: initial;\" title=\"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.10.15~11.14\uff09\" width=\"650\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/8-1549001803.jpg\" alt=\"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.10.15~11.14\uff09\"  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(61, 167, 66);\"><strong>\u7f57\u6c0f<\/strong><\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;\">\u5728\u68c0\u7d22\u65f6\u95f4\u8303\u56f4\u5185\uff0c\u7f57\u6c0f\u53ca\u5176\u5b50\u516c\u53f8\u57fa\u56e0\u6cf0\u514b\u516c\u5e03\u4e865\u4ef6\u4e13\u5229\u7533\u8bf7\uff08\u88683\uff09\uff1a1\uff09\u6d89\u53ca\u764c\u75c7\u7684\u67092\u4ef6\uff08WO 2018197653\u548cWO 2018189214\uff09\uff0c\u5176\u4e2d\uff0cWO 2018197653\u6d89\u53ca\u7ed3\u6676\u591a\u6676\u578b\u7269\uff0c\u4e14\u5316\u5408\u7269\u7684\u4f5c\u7528\u673a\u5236\u5c5e\u4e8ePI3K\uff08Phosphoinositide 3-kinases\uff09\u6291\u5236\u5242\uff0c\u800cWO 2018189214\u6d89\u53ca\u514d\u75ab\u4ea4\u8054\u7269\uff1b2\uff09\u6d89\u53ca\u547c\u5438\u7cfb\u7edf\u7684\u67092\u4ef6\uff08US 2018305355\u548cUS 2018298026\uff09\uff0c\u5176\u4e2d\uff0cUS 2018305355\u4e2d\u7684\u5316\u5408\u7269\u4f5c\u7528\u673a\u5236\u5c5e\u4e8eJak\uff08Janus kinase\uff09\u6291\u5236\u5242\uff0c\u800cUS 2018298026\u4e2d\u7684\u5316\u5408\u7269\u5177\u6709\u591a\u79cd\u4f5c\u7528\u673a\u5236\uff1a\u767d\u7ec6\u80de\u4ecb\u7d20-1\u53d7\u4f53\u76f8\u5173\u6fc0\u91761\uff08IRAK-1\uff09\u6291\u5236\u5242\u3001IRAK-4\u6291\u5236\u5242\u548c\u916a\u6c28\u9178\u86cb\u767d\u6fc0\u9176\uff08SYK\uff09\u6291\u5236\u5242\uff1b3\uff09\u6d89\u53ca\u611f\u67d3\u7684\u67091\u4ef6\uff08WO 2018189063\uff09\uff0c\u4e14\u8be5\u4e13\u5229\u7533\u8bf7\u516c\u5f00\u7684\u5316\u5408\u7269\u5c5e\u4e8e\u73af\u80bd\u7c7b\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-align: justify;text-indent: 0em;\"><img loading=\"lazy\" align=\"\" class=\"\"     height=\"551\" style=\"border-width: 0px;border-style: initial;border-color: initial;\" title=\"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.10.15~11.14\uff09\" width=\"650\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/9-1549001803.jpg\" alt=\"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.10.15~11.14\uff09\"  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-align: justify;\"><img loading=\"lazy\" align=\"\" class=\"\"     height=\"241\" style=\"border-width: 0px;border-style: initial;border-color: initial;\" title=\"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.10.15~11.14\uff09\" width=\"650\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/5-1549001804.jpg\" alt=\"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.10.15~11.14\uff09\"  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-align: justify;\"><img loading=\"lazy\" align=\"\" class=\"\"     height=\"453\" style=\"border-width: 0px;border-style: initial;border-color: initial;\" title=\"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.10.15~11.14\uff09\" width=\"650\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/7-1549001804.jpg\" alt=\"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.10.15~11.14\uff09\"  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-align: justify;\"><img loading=\"lazy\" align=\"\" class=\"\"     height=\"534\" style=\"border-width: 0px;border-style: initial;border-color: initial;\" title=\"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.10.15~11.14\uff09\" width=\"650\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/8-1549001805.jpg\" alt=\"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.10.15~11.14\uff09\"  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(61, 167, 66);background-color: rgb(255, 255, 255);\"><strong>\u6211\u56fd\u5236\u836f\u516c\u53f8\u53ca\u7814\u7a76\u673a\u6784<\/strong><\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;\">\u5728\u68c0\u7d22\u65f6\u95f4\u8303\u56f4\u5185\uff0c\u6211\u56fd\u5236\u836f\u516c\u53f8\u53ca\u7814\u7a76\u673a\u6784\u516c\u5f00\u4e8632\u4ef6\u4e13\u5229\u7533\u8bf7\uff0c\u4e3b\u8981\u96c6\u4e2d\u5728\u764c\u75c7\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u708e\u75c7\u548c\u611f\u67d3\u7b49\u3002\u4e0b\u9762\u9009\u53d6\u90e8\u5206\u4e13\u5229\u8fdb\u884c\u91cd\u70b9\u63cf\u8ff0\uff08\u88685\uff09\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;\">\u56db\u5ddd\u79d1\u4f26\u535a\u6cf0\u751f\u7269\u533b\u836f\u80a1\u4efd\u6709\u9650\u516c\u53f8\u76842\u4ef6\u4e13\u5229\u7533\u8bf7\u4e2d\uff0cWO 2018196677\u6d89\u53ca\u6c1f\u4ee3\u70ef\u4e19\u80fa\u884d\u751f\u7269\uff0c\u5176\u53ef\u7528\u4e8eVAP-l\uff08vascular adhesion protein-l\uff09\/SSAO\uff08semicarbazide-sensitive amine oxidase\uff09\u8fc7\u5ea6\u6d3b\u6027\u76f8\u5173\u7684\u75be\u75c5\u7684\u6cbb\u7597\uff0c\u5982\u708e\u75c7\u6027\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3001\u76ae\u80a4\u75c5\u3001\u7cd6\u5c3f\u75c5\u548c\u4e2d\u98ce\u7b49\uff1bWO 2018192407\u6d89\u53ca\u7ec6\u80de\u6bd2\u7d20\u3001\u8fde\u63a5\u4f53\u548c\u5076\u8054\u7269\uff0c\u4e14\u7ec6\u80de\u6bd2\u7d20\u548c\u5076\u8054\u7269\u53ef\u7528\u4e8e\u764c\u75c7\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;\">\u4e0a\u6d77\u65f6\u83b1\u751f\u7269\u6280\u672f\u6709\u9650\u516c\u53f8\u76842\u4ef6\u4e13\u5229\u7533\u8bf7\uff08WO 2018202202\u548cWO 2018196812\uff09\u5206\u522b\u6d89\u53caCDK\u6fc0\u9176\u6291\u5236\u5242\u548c\u86cb\u767d\u9176\u4f53\u6291\u5236\u5242\uff0c\u4e14\u90fd\u53ef\u5e94\u7528\u4e8e\u764c\u75c7\u9886\u57df\uff0c\u540c\u65f6\uff0cWO 2018202202\u4e2d\u7684\u5316\u5408\u7269\u8fd8\u53ef\u7528\u4e8e\u708e\u75c7\u3001\u611f\u67d3\u3001\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u548c\u795e\u7ecf\u53d8\u6027\u75be\u75c5\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;\">\u9c81\u5357\u5236\u836f\u96c6\u56e2\u80a1\u4efd\u6709\u9650\u516c\u53f8\u7684WO 2018196861\u6d89\u53ca\u542b\u6709\u544b\u5583\u7ed3\u6784\u7684\u4e9a\u6c28\u8132\u884d\u751f\u7269\uff0c\u5176\u53ef\u4f5c\u4e3a\u5432\u54da\u80fa2,3-\u53cc\u52a0\u6c27\u9176\u6291\u5236\u5242\uff0c\u7528\u4e8e\u764c\u75c7\u3001\u611f\u67d3\u3001\u795e\u7ecf\u9000\u884c\u6027\u75c5\u53d8\u3001\u6291\u90c1\u75c7\u3001\u7126\u8651\u75c7\u3001\u767d\u5185\u969c\u7684\u6cbb\u7597\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;\">\u6c5f\u82cf\u6052\u745e\u533b\u836f\u80a1\u4efd\u6709\u9650\u516c\u53f8\u7684WO 2018188643\u6d89\u53ca(1S,4S)-4-\u4e59\u6c27\u57fa-N-(2-((R)-9-(\u5421\u5576-2-\u57fa)-6-\u6c27\u6742\u87ba[4.5]\u7678-9-\u57fa)\u4e59\u57fa)-1,2,3,4-\u56db\u6c22\u8418-1-\u80fa\u7684\u5bcc\u9a6c\u9178\u76d0\uff0c\u5176\u4f5c\u4e3a&nbsp; \u963f\u7247\u6837\u7269\u8d28\u53d7\u4f53\u6fc0\u52a8\u5242\uff0c\u53ef\u7528\u4e8e\u591a\u79cd\u75be\u75c5\u9886\u57df\uff0c\u7279\u522b\u662f\u75bc\u75db\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;\">\u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u836f\u7269\u7814\u7a76\u6240\u516c\u5f00\u7684WO 2018188660\u6d89\u53ca\u4e00\u7c7b\u5177\u6709\u4e09\u6c2e\u5511\u5e76\u6c2e\u6742\u44ec\u7ed3\u6784\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\uff0c\u5176\u4f5c\u4e3aBRD4\uff08Bromodomain-containing protein 4\uff09\u6291\u5236\u5242\uff0c\u53ef\u7528\u4e8e\u591a\u79cd\u75be\u75c5\u7684\u6cbb\u7597\uff0c\u5c24\u5176\u662f\u764c\u75c7\uff1bWO 2018196681\u6d89\u53ca\u5149\u7a33\u5b9a\u6027\u6709\u6240\u63d0\u9ad8\u7684\u785d\u82ef\u5730\u5e73\u4e0e\u5f02\u70df\u9170\u80fa\u7684\u5171\u6676\uff0c\u53ef\u7528\u4e8e\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\uff08\u5305\u62ec\u9ad8\u8840\u538b\u7b49\uff09\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-align: justify;\"><img loading=\"lazy\" align=\"\" class=\"\"     height=\"187\" style=\"border-width: 0px;border-style: initial;border-color: initial;\" title=\"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.10.15~11.14\uff09\" width=\"650\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/10-1549001805.jpg\" alt=\"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.10.15~11.14\uff09\"  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-align: justify;\"><img loading=\"lazy\" align=\"\" class=\"\"     height=\"432\" style=\"border-width: 0px;border-style: initial;border-color: initial;\" title=\"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.10.15~11.14\uff09\" width=\"650\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/02\/9-1549001806.jpg\" alt=\"\u5168\u7403\u65b0\u516c\u5f00\u5c0f\u5206\u5b50\u5316\u5408\u7269\u4e13\u5229\u7533\u8bf7\uff082018.10.15~11.14\uff09\"  \/><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-align: justify;\">\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;color: rgb(61, 167, 66);background-color: rgb(255, 255, 255);\"><strong>\u5c0f\u7ed3<\/strong><\/span><\/p>\n<p style=\"margin-top: 10px;margin-bottom: 20px;font-family: sans-serif;font-size: 14px;line-height: 2;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;\"><span style=\"font-size: 15px;\">\u7ecf\u4e0a\u8ff0\u5206\u6790\u53ef\u77e5\uff0c\u5728\u68c0\u7d22\u65f6\u95f4\u8303\u56f4\u5185\uff0c\u56fd\u5916\u836f\u4f01\u7684\u4e13\u5229\u7533\u8bf7\u6570\u91cf\u4ecd\u7136\u5f88\u5927\uff0c\u540c\u65f6\uff0cNovintum Biotechnology\u3001\u8bfa\u534e\u548c\u7f57\u6c0f\u8fd93\u4e2a\u836f\u4f01\u7684\u4e13\u5229\u6d89\u53ca\u9886\u57df\u4e3b\u8981\u96c6\u4e2d\u5728\u764c\u75c7\u548c\u611f\u67d3\uff0c\u4f46\u8bfa\u534e\u8fd8\u6d89\u53ca\u773c\u79d1\u75be\u75c5\u65b9\u9762\uff0c\u7f57\u6c0f\u4e5f\u8fd8\u6d89\u53ca\u547c\u5438\u7cfb\u7edf\u65b9\u9762\u3002\u800c\u4e0a\u8ff0\u88685\u63cf\u8ff0\u7684\u6211\u56fd\u5c0f\u5206\u5b50\u4e13\u5229\u7533\u8bf7\u4e2d\uff0c\u53ef\u7528\u4e8e\u591a\u79cd\u75be\u75c5\u9886\u57df\uff0c\u5982\u764c\u75c7\u3001\u708e\u75c7\u3001\u5fc3\u8840\u7ba1\u75be\u75c5\u548c\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7b49\u3002<\/span><\/p>\n<p style=\"margin-top: 10px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;line-height: normal;margin-bottom: 5px;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n<p style=\"margin-top: 10px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;line-height: normal;margin-bottom: 5px;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">1.Thomson Reuters Integrity\u6570\u636e\u5e93, \u68c0\u7d22\u65e5\u671f: 2018\u5e7411\u670827\u65e5.<\/span><\/p>\n<p style=\"margin-top: 10px;font-family: sans-serif;font-size: 14px;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 2em;text-align: justify;line-height: normal;margin-bottom: 5px;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">2.\u4e07\u8c61\u4e91, \u68c0\u7d22\u65e5\u671f: 2018\u5e7411\u670827\u65e5.<\/span><\/p>\n<p style=\"margin-top: 5px;margin-bottom: 5px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);letter-spacing: 0.544px;text-align: justify;white-space: normal;font-family: sans-serif;font-size: 14px;background-color: rgb(255, 255, 255);text-indent: 2em;line-height: normal;box-sizing: border-box !important;word-wrap: break-word !important;\"><br  \/><\/p>\n<section class=\"\" style=\"max-width: 100%;color: rgb(51, 51, 51);font-family: -apple-system-font, BlinkMacSystemFont, &quot;Helvetica Neue&quot;, &quot;PingFang SC&quot;, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei UI&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;font-size: 17px;letter-spacing: 0.544px;text-align: justify;white-space: normal;background-color: rgb(255, 255, 255);box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin: 20px 10px;max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin: 10px;max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section  style=\"max-width: 100%;box-sizing: border-box;border-bottom: 1px solid rgb(160, 160, 160);width: 637px;word-wrap: break-word !important;\"><\/section>\n<\/section>\n<section style=\"margin-top: -10px;max-width: 100%;letter-spacing: 1px;text-align: right;box-sizing: border-box !important;word-wrap: break-word !important;\">\n<section style=\"margin-top: -1em;padding-right: 12px;padding-left: 12px;max-width: 100%;box-sizing: border-box;border-radius: 1em;display: inline-block;vertical-align: top;background: -webkit-linear-gradient(right, rgb(56, 116, 241), rgba(255, 247, 234, 0)) rgb(138, 229, 237);height: 1.8em;line-height: 1.8em;color: white;word-wrap: break-word !important;\">\n<p style=\"max-width: 100%;min-height: 1em;box-sizing: border-box !important;word-wrap: break-word !important;\">\u7248\u6743\u58f0\u660e<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"margin: 5px 16px;max-width: 100%;min-height: 1em;color: rgb(51, 51, 51);letter-spacing: 0.544px;text-align: justify;text-indent: 0em;white-space: normal;font-family: sans-serif;font-size: 14px;background-color: rgb(255, 255, 255);line-height: 1.75em;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;text-indent: 0em;font-family: &quot;Helvetica Neue&quot;, Helvetica, &quot;Hiragino Sans GB&quot;, &quot;Microsoft YaHei&quot;, Arial, sans-serif;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(120, 172, 254);box-sizing: border-box !important;word-wrap: break-word !important;\">\u6b22\u8fce\u4e2a\u4eba\u3001\u7f51\u7ad9\u3001\u516c\u4f17\u53f7\u7b49\u5f15\u7528\u3001\u8f6c\u8f7d\u548c\u5206\u4eab\u3002\u975e\u4e2a\u4eba\u8f6c\u8f7d\u6216\u5f15\u7528\u672c\u7f51\u7248\u6743\u6240\u6709\u5185\u5bb9\u987b\u83b7\u5f97\u6388\u6743\u5e76\u5728\u9192\u76ee\u5904\u6ce8\u660e\u201c\u8f6c\u81ea\uff1a\u201d\u3002\u6b22\u8fce\u5408\u4f5c\uff0c\u8bf7\u8054\u7cfbiddds@simm.ac.cn<\/span><\/strong><\/p>\n<p><br  \/><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u7f16\u8005\u6309\u3011\uff1a\u672c\u6587\u5bf9Thomson Reuters Integrity\u6570\u636e\u5e93\u6536\u5f55\u7684\u4e8e2018\u5e7410\u670815\u65e5\uff5e20 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":78381,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/78380"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=78380"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/78380\/revisions"}],"predecessor-version":[{"id":78393,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/78380\/revisions\/78393"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/78381"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=78380"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=78380"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=78380"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}