{"id":78394,"date":"2018-12-07T00:00:50","date_gmt":"2019-02-01T06:16:51","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/78394\/"},"modified":"2019-02-01T14:16:52","modified_gmt":"2019-02-01T06:16:52","slug":"de00d3895b","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/78394\/","title":{"rendered":"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c43\u671f\uff09"},"content":{"rendered":"
\n
\n
\n
\n
\n
\u56fd\u5916\u836f\u7269\u7814\u53d1\u52a8\u6001<\/span><\/section>\n<\/section>\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n

1. \u65e5\u524d\uff0c\u6b66\u7530\u5236\u836f\uff08Takeda\uff09\u9aa8\u9ad3\u7624\u836f\u7269NINLARO\u53d1\u5e03\u4e86\u7ef4\u6301\u6cbb\u7597\u8bd5\u9a8c\u7684\u79ef\u6781\u6570\u636e\u3002\u5728\u4e00\u9879\u540d\u4e3aTOURMALINE-MM3\u7684\u8bd5\u9a8c\u4e2d\uff0c\u7b2c\u4e00\u4e2a\u5173\u952e\u9636\u6bb5\u2162\u671f\u5b89\u6170\u5242\u5bf9\u7167\u8bd5\u9a8c\u8bc4\u4f30\u4e86\u86cb\u767d\u9176\u4f53\u6291\u5236\u5242NINLARO\uff08ixazomib\uff09\u4f5c\u4e3a\u9aa8\u9ad3\u7624\u7ef4\u6301\u6cbb\u7597\u7684\u6548\u679c\u3002\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u8be5\u836f\u7269\u53ef\u4ee5\u663e\u8457\u6539\u5584\u81ea\u4f53\u79fb\u690d\u540e\u6210\u4eba\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u7387\u3002<\/span>
<\/p>\n

2. \u8bfa\u534e\u8fd1\u65e5\u5728\u7f8e\u56fd\u5723\u5730\u4e9a\u54e5\u4e3e\u884c\u7684\u7b2c60\u5c4a\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08ASH2018\uff09\u5e74\u4f1a\u4e0a\u516c\u5e03\u4e86P-\u9009\u62e9\u7d20\u6291\u5236\u5242crizanlizumab\uff08SEG101\uff0c\u524d\u79f0SelG1\uff09\u6cbb\u7597\u9570\u72b6\u7ec6\u80de\u75c5\uff08SCD\uff09\u2161\u671f\u4e34\u5e8a\u7814\u7a76SUSTAIN\u4e8b\u540e\u5206\u6790\u7684\u65b0\u6570\u636e\u3002\u6570\u636e\u663e\u793a\uff0c\u5728\u575a\u6301\u6cbb\u7597\u65b9\u6848\u7684SCD\u60a3\u8005\u4e2d\uff0ccrizanlizumab\u6bcf\u6708\u4e00\u6b21\u6cbb\u7597\u65b9\u6848\u663e\u8457\u964d\u4f4e\u4e86SCD\u76f8\u5173\u7684\u4e25\u91cd\u5e76\u53d1\u75c7\u8840\u7ba1\u95ed\u585e\u6027\u5371\u8c61\uff08VOC\uff09\u3002<\/span><\/p>\n

3. \u963f\u65af\u5229\u5eb7\uff08AstraZeneca\uff09\u65b0\u578bTLR9\u6fc0\u52a8\u5242AZD1419\u6cbb\u7597\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u6027\u54ee\u5598\u7684\u4e00\u9879\u2161a\u671f\u4e34\u5e8a\u906d\u9047\u5931\u8d25\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c43\u671f\uff09\"<\/p>\n

4. \u65e5\u672c\u836f\u4f01\u5927\u51a2\uff08Otsuka\uff09\u4e0e\u5408\u4f5c\u4f19\u4f34\u7075\u5317\uff08Lundbeck\uff09\u8fd1\u65e5\u8054\u5408\u5ba3\u5e03\uff0c\u8bc4\u4f30Rxulti\uff08brexpiprazole\uff0c\u4f9d\u5339\u54cc\u5511\uff09\u6cbb\u7597\u521b\u4f24\u540e\u5e94\u6fc0\u969c\u788d\uff08PTSD\uff09\u7684\u2161\u671f\u4e34\u5e8a\u7814\u7a76\uff08NCT03033069\uff09\u83b7\u5f97\u4e86\u79ef\u6781\u7ed3\u679c\u3002\u53cc\u65b9\u5df2\u8ba1\u5212\u4e0e\u7f8e\u56fdFDA\u4f1a\u9762\uff0c\u8ba8\u8bba\u8fd9\u9879\u2161\u671f\u7814\u7a76\u7684\u7ed3\u679c\uff0c\u5e76\u8bc4\u4f30brexpiprazole\u4e34\u5e8a\u9879\u76ee\u7684\u4e0b\u4e00\u6b65\u9aa4\u3002<\/span><\/p>\n

5. \u7f8e\u56fd\u751f\u7269\u5236\u836f\u516c\u53f8\u518d\u751f\u5143\uff08Regeneron\uff09\u8fd1\u65e5\u57282018\u5e74\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08ASH\uff09\u5e74\u4f1a\u4e0a\u516c\u5e03\u4e86\u53cc\u7279\u5f02\u6027\u6297\u4f53REGN1979\u6cbb\u7597\u590d\u53d1\u6027\u6216\u96be\u6cbb\u6027B\u7ec6\u80de\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08R\/R B-NHL\uff09\u7684\u2160\u671f\u6982\u5ff5\u9a8c\u8bc1\u7814\u7a76\u7684\u65b0\u6570\u636e\uff0c\u5305\u62ec\u6cbb\u7597\u4e24\u79cd\u6700\u5e38\u89c1\u7684NHL\u2014\u2014\u6ee4\u6ce1\u6027\u6dcb\u5df4\u7624\uff08FL\uff09\u548c\u5f25\u6f2b\u6027\u5927B\u7ec6\u80de\u6dcb\u5df4\u764c\uff08DLBCL\uff09\u7684\u79ef\u6781\u4e34\u5e8a\u7ed3\u679c\u3002<\/span><\/p>\n

6. \u6768\u68ee\uff08Janssen Pharmaceutical Companies\uff09\u65d7\u4e0b\u5b50\u516c\u53f8Cilag GmbH International\u4e0e\u4f4d\u4e8e\u6b27\u6d32\u7684argenx\u8fbe\u6210\u534f\u8bae\uff0c\u83b7\u5f97\u4e86\u5176\u6297\u4f53\u836f\u7269cusatuzumab\uff08ARGX-110\uff09\u7684\u6388\u6743\u3002\u4f5c\u4e3a\u534f\u8bae\u7684\u4e00\u90e8\u5206\uff0c\u6768\u68ee\u652f\u4ed8\u4e863\u4ebf\u7f8e\u5143\u7684\u5148\u671f\u4ed8\u6b3e\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u5f3a\u751f\u65d7\u4e0b\u7684JJDC\u4e5f\u5c06\u505a2\u4ebf\u7f8e\u5143\u7684\u80a1\u6743\u6295\u8d44\u3002<\/span><\/p>\n

7. \u845b\u5170\u7d20\u53f2\u514b\uff08GSK\uff09\u5ba3\u5e03\uff0c\u516c\u53f8\u5c06\u6536\u8d2d\u603b\u90e8\u4f4d\u4e8e\u7f8e\u56fd\u9a6c\u8428\u8bf8\u585e\u5dde\u7684\u80bf\u7624\u5b66\u836f\u7269\u7814\u53d1\u516c\u53f8TESARO\u3002\u4e24\u5bb6\u516c\u53f8\u5df2\u8fbe\u6210\u6700\u7ec8\u534f\u8bae\uff0c\u4ee5\u6bcf\u80a175\u7f8e\u5143\u7684\u73b0\u91d1\u8fdb\u884c\u6536\u8d2d\uff0c\u603b\u4ef7\u7ea651\u4ebf\u7f8e\u5143\uff0840\u4ebf\u82f1\u9551\uff09\uff0c\u4ef7\u6ea2110\uff05\u3002\u62df\u8bae\u7684\u4ea4\u6613\u5c06\u5927\u5927\u52a0\u5f3aGSK\u7684\u5236\u836f\u4e1a\u52a1\u677f\u5757\uff0c\u52a0\u901fGSK\u7ba1\u9053\u836f\u7269\u5efa\u8bbe\u548c\u80bf\u7624\u65b9\u9762\u7684\u5546\u4e1a\u5316\u80fd\u529b\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c43\u671f\uff09\"<\/p>\n

8. \u81f4\u529b\u4e8e\u773c\u79d1\u75be\u75c5\u521b\u65b0\u6cbb\u7597\u7684\u751f\u7269\u533b\u836f\u516c\u53f8Ocular Therapeutix\u5ba3\u5e03\uff0c\u5176\u7528\u4e8e\u6cbb\u7597\u773c\u79d1\u624b\u672f\u540e\u773c\u90e8\u75bc\u75db\u7684\u836f\u7269Dextenza\uff08\u5730\u585e\u7c73\u677e\u7f13\u91ca\u6cea\u70b9\u585e\uff09\u83b7\u5f97\u7f8e\u56fdFDA\u6279\u51c6\u3002<\/span><\/p>\n

9. FDA\u53d1\u5e03\u4e86\u6cbb\u7597\u975e\u809d\u786c\u5316\u6027\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u4f34\u809d\u7ea4\u7ef4\u5316\u60a3\u8005\u7684\u836f\u7269\u5f00\u53d1\u6307\u5357\u8349\u6848\u3002<\/span><\/p>\n

10. \u7f57\u6c0f\u5ba3\u5e03\u5176Kadcyla\u4f5c\u4e3a\u672f\u540e\u8f85\u52a9\u7597\u6cd5\uff0c\u5728\u6cbb\u7597HER2\u9633\u6027\u65e9\u671f\u4e73\u817a\u764c\u76843\u671f\u8bd5\u9a8cKATHERINE\u4e2d\uff0c\u8fbe\u5230\u4e86\u8bd5\u9a8c\u7684\u4e3b\u8981\u7ec8\u70b9\u3002\u8be5\u8bd5\u9a8c\u7684\u7ed3\u679c\u540c\u65f6\u53d1\u5e03\u57282018\u5e74\u5723\u5b89\u4e1c\u5c3c\u5965\u4e73\u817a\u764c\u8bba\u575b\uff0c\u548c\u8fd1\u65e5\u51fa\u7248\u7684\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\u4e0a\u3002<\/span><\/p>\n

11. \u8bfa\u534e\u5728NASH\u9886\u57df\u7684\u5408\u4f5c\u4f19\u4f34Conatus\u5ba3\u5e03\u5176\u6cdb\u80f1\u5929\u86cb\u767d\u9176\u6291\u5236\u5242emricasan\u5728\u4e00\u4e2aNASH\u2161\u671f\u4e34\u5e8a\u5931\u8d25\u3002\u8fd9\u4e2a\u53eb\u505aENCORE-PH\u7684\u2161\u671f\u4e34\u5e8a\u62db\u52df263\u4f4dNASH\u809d\u786c\u5316\u60a3\u8005\uff0c\u5176\u4e2d\u591a\u6570\uff0876%\uff09\u662f\u76f8\u5bf9\u8f83\u8f7b\u7684\u4ee3\u507f\u6027\u809d\u786c\u5316\u60a3\u8005\u3001\u5176\u4f5924%\u4e3a\u65e9\u671f\u4ee3\u507f\u4e0d\u5168\u809d\u786c\u5316\u3002\u8fd9\u4e2a\u8bd5\u9a8c\u6bd4\u8f83\u4e09\u4e2a\u5242\u91cf\u7684emricasan\u548c\u5b89\u6170\u5242\u572824\u5468\u5bf9\u809d\u9759\u8109\u8840\u538b(HVPG)\u7684\u5f71\u54cd\uff0c\u4e00\u7ea7\u7ec8\u70b9\u4e3a\u4efb\u4f55\u5242\u91cf\u4f18\u4e8e\u5b89\u6170\u5242\u3002\u867d\u7136\u4e9a\u7ec4\u5206\u6790\u663e\u793a\u4e00\u5b9a\u7597\u6548\u4fe1\u53f7\u4f46\u6574\u4e2a\u8bd5\u9a8c\u9519\u8fc7\u4e86\u4e00\u7ea7\u7ec8\u70b9\u3002<\/span><\/p>\n

12. \u56e0\u836f\u7269\u6bd2\u6027\uff0c\u62dc\u8033\u5b50\u5bab\u808c\u7624\u836fvilaprisan\u2162\u671f\u8bd5\u9a8c\u6682\u505c\u3002\u8fd9\u6b3e\u836f\u7269\u662f\u62dc\u8033\u7814\u53d1\u7684\u4e00\u79cd\u65b0\u578b\u53e3\u670d\u753e\u4f53\u9009\u62e9\u6027\u5b55\u916e\u53d7\u4f53\u8c03\u8282\u5242\uff08SPRM\uff09\uff0c\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u5b50\u5bab\u808c\u7624\u548c\u5b50\u5bab\u5185\u819c\u5f02\u4f4d\u75c7\uff0c\u4e5f\u88ab\u5916\u754c\u8ba4\u4e3a\u5728\u8fd9\u4e00\u9886\u57df\u5177\u6709\u6210\u4e3a\u91cd\u78c5\u70b8\u5f39\u7684\u53ef\u80fd\uff0c\u9884\u671f\u7684\u9ad8\u5cf0\u5e74\u9500\u552e\u989d\u5c06\u8d85\u8fc710\u4ebf\u6b27\u5143\u3002\u5b83\u662f\u9ec4\u4f53\u916e\u53d7\u4f53\uff08PR\uff09\u7684\u6709\u6548\u548c\u9ad8\u9009\u62e9\u6027\u90e8\u5206\u6fc0\u52a8\u5242\u3002<\/span><\/p>\n

\n
\n
\n
\n
\u56fd\u5185\u836f\u7269\u7814\u53d1\u52a8\u6001<\/span><\/section>\n<\/section>\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n

1. 12\u67083\u65e5\uff0c\u666e\u5229\u5236\u836f\u516c\u544a\u79f0\uff0c\u516c\u53f8\u751f\u4ea7\u7684\u6ce8\u5c04\u7528\u4f0f\u7acb\u5eb7\u5511\uff08200mg\uff09\u901a\u8fc7FDA\u7684\u4e0a\u5e02\u6279\u51c6\uff0c\u5177\u5907\u4e86\u5728\u7f8e\u56fd\u9500\u552e\u7684\u8d44\u683c\u3002<\/span>
<\/p>\n

2. \u4f18\u65f6\u6bd4\u5ba3\u5e03\uff0c\u65d7\u4e0b\u6297\u766b\u75eb\u521b\u65b0\u836f\u7269\u7ef4\u6d3e\u7279\u00ae\uff08\u62c9\u8003\u6c99\u80fa\u7247\uff09\u5df2\u83b7\u5f97\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u7684\u6279\u51c6\uff0c\u7528\u4e8e\u6210\u4eba\u53ca\u9752\u5c11\u5e74\uff0816~18\u5c81\uff09\u766b\u75eb\u60a3\u8005\u4f34\u6709\u6216\u4e0d\u4f34\u6709\u7ee7\u53d1\u6027\u5168\u9762\u6027\u53d1\u4f5c\u7684\u90e8\u5206\u6027\u53d1\u4f5c\u7684\u8054\u5408\u6cbb\u7597\u3002<\/span><\/p>\n

3. \u56fd\u5bb6\u533b\u4fdd\u5c40\u5370\u53d1\u300a\u5173\u4e8e\u5f53\u524d\u52a0\u5f3a\u533b\u4fdd\u534f\u8bae\u7ba1\u7406\u786e\u4fdd\u57fa\u91d1\u5b89\u5168\u6709\u5173\u5de5\u4f5c\u7684\u901a\u77e5\u300b\uff0c\u8981\u6c42\u5404\u5730\u533b\u4fdd\u7ecf\u529e\u673a\u6784\u52a0\u5f3a\u5bf9\u5b9a\u70b9\u533b\u836f\u673a\u6784\u7684\u534f\u8bae\u7ba1\u7406\uff0c\u786e\u4fdd\u533b\u4fdd\u57fa\u91d1\u5b89\u5168\u3002<\/span><\/p>\n

4. \u57282018\u5e74\u7f8e\u56fd\u8840\u6db2\u5b66\u4f1a\uff08ASH\uff09\u5e74\u4f1a\u4e0a\uff0c\u767e\u6d4e\u795e\u5dde\u3001\u4e9a\u76db\u533b\u836f\u3001\u5357\u4eac\u4f20\u5947\u516c\u5e03\u4e34\u5e8a\u836f\u7269\u591a\u9879\u5173\u952e\u6570\u636e\u3002<\/span><\/p>\n

5. \u636e\u56fd\u5bb6\u836f\u76d1\u5c40\u5b98\u7f51\u663e\u793a\uff0c\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u8fd1\u65e5\u5df2\u6279\u51c6\u827e\u7f8e\u8d5b\u73e0\u5355\u6297\u6ce8\u5c04\u6db2\uff08\u82f1\u6587\u540d\uff1aEmicizumab Injection\uff09\u8fdb\u53e3\u6ce8\u518c\u7533\u8bf7\uff0c\u7528\u4e8e\u6cbb\u7597\u5b58\u5728\u51dd\u8840\u56e0\u5b50\u2167\u6291\u5236\u7269\u7684A\u578b\u8840\u53cb\u75c5\u60a3\u8005\u3002<\/span><\/p>\n

6. \u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u66f4\u65b0\u541b\u5b9e\u751f\u7269\u7279\u745e\u666e\u5229\u5355\u6297\uff08JS001\uff09\u5ba1\u8bc4\u8fdb\u5ea6\uff0c\u8be5\u836f\u7269\u5df2\u7ecf\u8fdb\u5165”\u5728\u5ba1\u6279”\uff0c\u836f\u7269\u7533\u8bf7\u9002\u5e94\u75c7\u4e3a\u7ecf\u6cbb\u7684\u9ed1\u8272\u7d20\u7624\u60a3\u8005\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u5373\u5c06\u6210\u4e3a\u9996\u4e2a\u83b7\u6279\u4e0a\u5e02\u7684\u56fd\u4ea7PD-1\u6297\u4f53\u3002<\/span><\/p>\n

\"\u6bcf\u5468\u836f\u8baf\uff082018\u5e74\u7b2c43\u671f\uff09\"<\/p>\n

7. \u836f\u5ba1\u4e2d\u5fc3\u53d1\u5e03\u300a\u5173\u4e8e\u836f\u5ba1\u4e2d\u5fc3\u7f51\u7ad9\u5f00\u901a\u4e34\u5e8a\u9ed8\u793a\u8bb8\u53ef\u76f8\u5173\u529f\u80fd\u7684\u901a\u77e5\u300b\u79f0\uff0c\u6839\u636e\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u300a\u5173\u4e8e\u8c03\u6574\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u5ba1\u8bc4\u5ba1\u6279\u7a0b\u5e8f\u7684\u516c\u544a\u300b\uff082018\u5e74\u7b2c50\u53f7\uff0c\u4ee5\u4e0b\u7b80\u79f050\u53f7\u516c\u544a\uff09\uff0c\u836f\u5ba1\u4e2d\u5fc3\u5728\u7f51\u7ad9\u589e\u52a0\u4e86\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u7ed3\u8bba\u67e5\u8be2\u3001\u901a\u77e5\u4e66\u4e0b\u8f7d\u548c\u8865\u5145\u8d44\u6599\u63d0\u4ea4\u529f\u80fd\u3002<\/span><\/p>\n

8. \u6052\u745e\u533b\u836f\u516c\u544a\u79f0\uff0c\u516c\u53f8\u53ca\u5b50\u516c\u53f8\u4e0a\u6d77\u6052\u745e\u533b\u836f\u5c06\u4e8e\u8fd1\u671f\u5f00\u5c55SHR-1316\u6ce8\u5c04\u6db2\u7684\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><\/p>\n

9. \u5409\u5229\u5fb7\u79d1\u5b66\u5ba3\u5e03\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u590f\u5e06\u5b81\u00ae\uff08\u6765\u8fea\u6d3e\u97e690mg\/\u7d22\u78f7\u5e03\u97e6400mg\uff09\u5728\u4e2d\u56fd\u7528\u4e8e\u6cbb\u75971-6\u578b\u6162\u6027\u4e19\u578b\u809d\u708e\u75c5\u6bd2(HCV)\u611f\u67d3\u7684\u6210\u4eba\u548c12\u81f318\u5c81\u9752\u5c11\u5e74\u60a3\u8005\u3002<\/span><\/p>\n

10. \u79d1\u4f26\u836f\u4e1a\u8fde\u53d1\u4e24\u4e2a\u516c\u544a\uff0c\u516c\u53f8\u7684\u6c22\u6eb4\u9178\u897f\u915e\u666e\u5170\u7247(20mg)\u3001\u76d0\u9178\u514b\u6797\u9709\u7d20\u80f6\u56ca(0.075g\u30010.15g)\u901a\u8fc7\u4eff\u5236\u836f\u4e00\u81f4\u6027\u8bc4\u4ef7\uff0c\u5176\u4e2d\u6c22\u6eb4\u9178\u897f\u915e\u666e\u5170\u7247(20mg)\u4e3a\u9996\u5bb6\u901a\u8fc7\u3002<\/span><\/p>\n

11. 7+4\u5e26\u91cf\u91c7\u8d2d\u9884\u4e2d\u9009\u7ed3\u679c\u51fa\u7089\uff0c\u4e2d\u9009\u54c1\u79cd\u5927\u5e45\u5ea6\u964d\u4ef7\u3002\u5176\u4e2d\u6069\u66ff\u5361\u97e6\u964d\u4ef790%\uff0c\u6052\u745e\u5384\u8d1d\u6c99\u5766\u964d\u4ef760%\u3002\u4eac\u65b0\u836f\u4e1a\u6c28\u6c2f\u5730\u5e73\u4ee50.14\u5143\u7684\u4ef7\u683c\u83b7\u5f97\u9884\u4e2d\u9009\u8d44\u683c\u3002\u6b63\u5927\u5929\u6674\u6069\u66ff\u5361\u97e6\u5206\u6563\u7247\u4ee50.62\u5143\u7684\u4ef7\u683c\u6216\u9884\u4e2d\u9009\u8d44\u683c\u3002<\/span><\/p>\n

\n
\n
\n
\n
\u673a\u5236\/\u9776\u70b9\u7814\u7a76\u8fdb\u5c55<\/section>\n<\/section>\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n

1. \u8fd1\u65e5\uff0c\u6765\u81ea\u4ee5\u8272\u5217\u7279\u62c9\u7ef4\u592b\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u7814\u7a76\u53d1\u73b0\uff0c\u4e73\u817a\u80bf\u7624\u6216\u80fd\u901a\u8fc7\u62db\u52df\u9aa8\u9ad3\u4e2d\u5f62\u6210\u7684\u95f4\u8d28\u7ec6\u80de\u6765\u589e\u5f3a\u4e73\u817a\u764c\u7ec6\u80de\u7684\u751f\u957f\uff0c\u76f8\u5173\u7814\u7a76\u520a\u767b\u4e8e\u56fd\u9645\u6742\u5fd7Journal of Experimental Medicine\u4e0a\uff0c\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u9aa8\u9ad3\u4e2d\u884d\u751f\u7684\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u62db\u52df\u8fc7\u7a0b\u80fd\u964d\u4f4e\u4e73\u817a\u764c\u60a3\u8005\u7684\u5b58\u6d3b\u51e0\u7387\uff0c\u56e0\u6b64\u9776\u5411\u4f5c\u7528\u8fd9\u4e9b\u7ec6\u80de\u6216\u8bb8\u6709\u671b\u6709\u6548\u6cbb\u7597\u4e73\u817a\u764c\u3002<\/span>
<\/p>\n

2. \u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u4e2d\u56fd\u5e7f\u897f\u5987\u5e7c\u4fdd\u5065\u9662\u3001\u53f0\u5927\u533b\u9662\u4ee5\u53ca\u7f8e\u56fd\u8f9b\u8f9b\u90a3\u63d0\u513f\u7ae5\u533b\u5b66\u4e2d\u5fc3\u3001\u8d1d\u52d2\u533b\u5b66\u9662\u548c\u6885\u5965\u8bca\u6240\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u4e00\u4e9b\u7f55\u89c1\u7684\u7236\u4eb2\u5c06\u7ebf\u7c92\u4f53DNA\uff08mtDNA\uff09\u4f20\u9012\u7ed9\u5b50\u5973\u7684\u4f8b\u5b50\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u4e8e2018\u5e7411\u670826\u65e5\u5728\u7ebf\u53d1\u8868\u5728PNAS\u671f\u520a\u4e0a\uff0c\u8bba\u6587\u6807\u9898\u4e3a\u201cBiparental Inheritance of Mitochondrial DNA in Humans\u201d\u3002<\/span><\/p>\n

3. \u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u7f8e\u56fd\u7ea6\u7ff0\u970d\u666e\u91d1\u65af\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u8ffd\u8e2a\u4e86\u4e24\u4e2a\u7537\u6027HIV\u611f\u67d3\u8005\u3002\u5728\u5e38\u89c4\u7684\u8840\u6db2\u6d4b\u8bd5\u4e2d\uff0c\u8fd9\u4e24\u4e2a\u7537\u6027HIV\u611f\u67d3\u8005\u5177\u6709\u65e0\u6cd5\u68c0\u6d4b\u5230\u7684HIV\u6c34\u5e73\uff0c\u5176\u4e2d\u7684\u4e00\u4e2a\u4eba\u662f\u6240\u8c13\u7684\u7cbe\u82f1\u63a7\u5236\u8005\uff08elite controller\uff09\uff0c\u5728\u4ed6\u7684\u514d\u75ab\u7ec6\u80de\u8868\u9762\u4e0a\u643a\u5e26\u7740\u7684\u57fa\u56e0\u6807\u5fd7\u7269HLA-B*57\u80fd\u591f\u8ba9\u4eba\u4f53\u5728\u4e0d\u63a5\u53d7\u6cbb\u7597\u7684\u60c5\u5f62\u4e0b\u5929\u7136\u5730\u4fdd\u6301\u8f83\u4f4e\u7684\u8840\u6db2HIV\u6c34\u5e73\uff1b\u53e6\u4e00\u4e2a\u4eba\u662f\u6240\u8c13\u7684\u6cbb\u7597\u540e\u63a7\u5236\u8005\uff08post-treatment controller\uff09\uff0c\u5728\u5c06\u8fd120\u5e74\u524d\u611f\u67d3\u4e0aHIV\uff0c\u63a5\u53d7\u4e86\u6297\u9006\u8f6c\u5f55\u75c5\u6bd2\u6cbb\u7597\u51e0\u5e74\u540e\uff0c\u505c\u6b62\u4e86\u8fd9\u79cd\u6cbb\u7597\uff0c\u572815\u591a\u5e74\u7684\u65f6\u95f4\u91cc\u4e00\u76f4\u4fdd\u6301\u65e0\u6cd5\u68c0\u6d4b\u5230\u7684\u8840\u6db2HIV\u6c34\u5e73\uff0c\u66f4\u91cd\u8981\u7684\u662f\uff0c\u4ed6\u7684\u514d\u75ab\u7ec6\u80de\u8868\u9762\u4e0a\u5e76\u672a\u643a\u5e26\u4efb\u4f55\u4fdd\u62a4\u6027\u7684\u57fa\u56e0\u6807\u5fd7\u7269\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u8fd1\u671f\u53d1\u8868\u5728JCI Insight\u671f\u520a\u4e0a\uff0c\u8bba\u6587\u6807\u9898\u4e3a\u201cLong-term remission despite clonal expansion of replication-competent HIV-1 isolates\u201d\u3002<\/span><\/p>\n

\n

4. \u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u65e5\u672c\u7406\u5316\u5b66\u7814\u7a76\u6240\u3001\u91d1\u6cfd\u5927\u5b66\u3001\u65e9\u7a3b\u7530\u5927\u5b66\u3001\u5188\u5c71\u5927\u5b66\u3001\u4e5d\u5dde\u5927\u5b66\u548c\u5317\u91cc\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u7814\u7a76\u4e86\u80be\u810f\u529f\u80fd\u4e0e\u80a0\u9053\u83cc\u7fa4\u4e4b\u95f4\u53ef\u80fd\u5b58\u5728\u7684\u5173\u8054\u6027\u3002\u4e3a\u4e86\u8bc4\u4f30\u6025\u6027\u80be\u635f\u4f24\uff08acute kidney injury, AKI\uff09\u5bf9\u80a0\u9053\u83cc\u7fa4\u7684\u5f71\u54cd\uff0c\u4ed6\u4eec\u5bf9AKI\u5c0f\u9f20\u6a21\u578b\u5728\u906d\u53d7\u7f3a\u8840\/\u518d\u704c\u6ce8\uff08ischemia\/reperfusion, I\/R\uff09\u635f\u4f24\u540e\u7684\u7caa\u4fbf\u8fdb\u884c\u80a0\u9053\u83cc\u7fa4\u5206\u6790\uff0c\u7ed3\u679c\u53d1\u73b0\u7279\u5b9a\u7684\u80a0\u9053\u7ec6\u83cc\u53d7\u5230AKI\u635f\u4f24\u7684\u5f71\u54cd\u3002\u6b64\u5916\uff0c\u4ed6\u4eec\u8fd8\u63a2\u7a76\u4e86\u80a0\u9053\u83cc\u7fa4\u662f\u5426\u4fc3\u8fdbAKI\u75c5\u53d8\u3002\u4ed6\u4eec\u8bf1\u5bfc\u63a5\u53d7\u6216\u672a\u63a5\u53d7\u6765\u81ea\u6b63\u5e38\u5c0f\u9f20\u7684\u7caa\u4fbf\u79fb\u690d\u7684\u65e0\u83cc\u5c0f\u9f20\u53d1\u751fAKI\u635f\u4f24\u3002\u76f8\u6bd4\u4e8e\u6b63\u5e38\u7684B6\u5c0f\u9f20\uff0cI\/R\u635f\u4f24\u5728\u65e0\u83cc\u7684B6\u5c0f\u9f20\u66f4\u52a0\u4e25\u91cd\u3002\u4ee4\u4eba\u5173\u6ce8\u7684\u662f\uff0c\u63a5\u53d7\u6765\u81ea\u6b63\u5e38\u5c0f\u9f20\u7684\u7caa\u4fbf\u79fb\u690d\u53ef\u7f13\u89e3\u65e0\u83ccB6\u5c0f\u9f20\u7684\u80be\u810f\u75c5\u53d8\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660eI\/R\u635f\u4f24\u53ef\u5bfc\u81f4\u80a0\u9053\u83cc\u7fa4\u53d1\u751f\u53d8\u5316\uff0c\u800c\u4e14\u6b63\u5e38\u5c0f\u9f20\u7684\u80a0\u9053\u83cc\u7fa4\u53ef\u80fd\u4f1a\u4ea7\u751f\u4fdd\u62a4\u80be\u810f\u7684\u5206\u5b50\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u8fd1\u671f\u53d1\u8868\u5728JCI Insight\u671f\u520a\u4e0a\uff0c\u8bba\u6587\u6807\u9898\u4e3a\u201cGut microbiota\u2013derived D-serine protects against acute kidney injury\u201d\u3002D-\u4e1d\u6c28\u9178\u5728\u4fdd\u62a4\u80be\u810f\u514d\u53d7AKI\u635f\u4f24\u4e2d\u8d77\u5230\u91cd\u8981\u4f5c\u7528\u3002<\/span><\/p>\n

5. \u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u7f8e\u56fd\u897f\u8fbe-\u8d5b\u5948\u533b\u7597\u4e2d\u5fc3\uff08Cedars-Sinai Medical Center\uff09\u7684Michael Freeman\u535a\u58eb\u53ca\u5176\u56e2\u961f\u5206\u6790\u4e86\u4e00\u4e2a\u5927\u578b\u6570\u636e\u5e93\u4e2d\u7684\u6765\u81ea\u764c\u75c7\u60a3\u8005\u7684\u9057\u4f20\u6570\u636e\u548c\u5206\u5b50\u6570\u636e[1]\u3002\u4ed6\u4eec\u53d1\u73b0\u7684\u8bc1\u636e\u8868\u660e\u5728\u6765\u81ea\u5bf9\u6fc0\u7d20\u7597\u6cd5\u4ea7\u751f\u62b5\u6297\u6027\u7684\u524d\u5217\u817a\u764c\u60a3\u8005\u7684\u80bf\u7624\u4e2d\uff0cOnecut2\u5206\u5b50\u7684\u6d3b\u6027\u589e\u52a0\u4e86\u3002\u4f5c\u4e3a\u4e00\u79cd\u8f6c\u5f55\u56e0\u5b50\uff0cOnecut2\u662f\u8eab\u4f53\u4ea7\u751f\u67d0\u4e9b\u86cb\u767d\u6240\u9700\u7684\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u4e8e2018\u5e7411\u670826\u65e5\u5728\u7ebf\u53d1\u8868\u5728Nature Medicine\u671f\u520a\u4e0a\uff0c\u8bba\u6587\u6807\u9898\u4e3a\u201cONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis\u201d\u3002<\/span><\/p>\n

6. \u8fd1\u65e5\uff0c\u4e00\u9879\u520a\u767b\u5728\u56fd\u9645\u6742\u5fd7Science Advances\u4e0a\u7684\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u7279\u62c9\u534e\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u4eec\u901a\u8fc7\u5bf9\u5fae\u7c92\u5b50\u8fdb\u884c\u5de5\u7a0b\u5316\u6539\u9020\uff0c\u4f7f\u5176\u80fd\u591f\u8fd0\u8f93\u57fa\u56e0\u8c03\u8282\u7269\u8d28\u8fdb\u5165\u9020\u8840\u5e72\u7956\u7ec6\u80de\uff08hematopoietic stem and progenitor cells\uff09\uff0c\u6700\u7ec8\u5728\u57fa\u56e0\u7597\u6cd5\u9886\u57df\u53d6\u5f97\u4e86\u65b0\u7684\u7814\u7a76\u7a81\u7834\u3002<\/span><\/p>\n

7. \u4e00\u9879\u520a\u767b\u5728\u56fd\u9645\u6742\u5fd7Nature Medicine\u4e0a\u7684\u7814\u7a76\u62a5\u544a\u4e2d\uff0c\u6765\u81ea\u52a0\u5229\u798f\u5c3c\u4e9a\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u7814\u7a76\u9274\u522b\u51fa\u4e86\u53c2\u4e0e\u75f4\u5446\u75c7\u60a3\u8005\u795e\u7ecf\u53d8\u6027\u53d1\u75c5\u7684\u9057\u4f20\u8fc7\u7a0b\u3002\u6587\u7ae0\u4e2d\uff0c\u7814\u7a76\u8005\u53d1\u73b0\u4e86\u53c2\u4e0e\u7a81\u53d8\u7684\u4e24\u5927\u7c7b\u57fa\u56e0\uff0c\u8fd9\u4e9b\u57fa\u56e0\u7a81\u53d8\u4f1a\u5bfc\u81f4tau\u86cb\u767d\u7684\u8fc7\u91cf\u8868\u8fbe\uff0c\u800c\u8fd9\u662f\u75f4\u5446\u75c7\u60a3\u8005\u673a\u4f53\u4e2d\u795e\u7ecf\u5143\u8fdb\u884c\u6027\u7f3a\u5931\u7684\u6807\u5fd7\u3002<\/span><\/p>\n

8. \u660f\u7761\u75c5\u662f\u4e00\u79cd\u79f0\u4e3a\u9525\u866b\uff08Trypanosome, \u4e5f\u8bd1\u4f5c\u9525\u4f53\u866b\uff09\u7684\u5bc4\u751f\u866b\u611f\u67d3\u9020\u6210\u7684\u75be\u75c5\uff0c\u6d41\u884c\u4e8e\u4e2d\u90e8\u975e\u6d32\u3002\u9525\u866b\u80fd\u591f\u8c03\u8282\u5b83\u4eec\u5728\u4e0d\u540c\u72b6\u6001\u4e0b\u8fdb\u884c\u5207\u6362\u7684\u65b9\u5f0f\u4ee5\u81f3\u4e8e\u5b83\u4eec\u80fd\u591f\u901a\u8fc7\u53d7\u611f\u67d3\u7684\u91c7\u91c7\u8747\u53ee\u54ac\u4f20\u64ad\u7ed9\u4eba\u7c7b\u3002\u5728\u4e00\u9879\u65b0\u7684\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u82cf\u683c\u5170\u7231\u4e01\u5821\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u9525\u866b\u91ca\u653e\u80bd\u9176\uff0c\u5373\u7528\u6765\u5c06\u8840\u6db2\u4e2d\u7684\u86cb\u767d\u5206\u89e3\u4e3a\u5c0f\u5206\u5b50\u7684\u9176\u3002\u8fd9\u4e9b\u79f0\u4e3a\u5be1\u80bd\u7684\u5c0f\u5206\u5b50\u7531\u4f4d\u4e8e\u9525\u866b\u8868\u9762\u4e0a\u53d1\u73b0\u7684\u86cb\u767dGPR89\u8fdb\u884c\u68c0\u6d4b\u3002\u8fd9\u4f1a\u89e6\u53d1\u9525\u866b\u8fdb\u5165\u4e00\u79cd\u5b83\u4eec\u80fd\u591f\u88ab\u91c7\u91c7\u8747\u6444\u5165\u548c\u4f20\u64ad\u7684\u72b6\u6001\u3002\u76f8\u5173\u7814\u7a76\u7ed3\u679c\u4e8e2018\u5e7411\u670829\u65e5\u5728\u7ebf\u53d1\u8868\u5728\u671f\u520a\u4e0a\uff0c\u8bba\u6587\u6807\u9898\u4e3a\u201cOligopeptide Signaling through TbGPR89 Drives Trypanosome Quorum Sensing\u201d\u3002<\/span><\/p>\n

\n
\n
\n
<\/section>\n<\/section>\n
\n
\n

\u7248\u6743\u58f0\u660e<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u6b22\u8fce\u4e2a\u4eba\u3001\u7f51\u7ad9\u3001\u516c\u4f17\u53f7\u7b49\u5f15\u7528\u3001\u8f6c\u8f7d\u548c\u5206\u4eab\u3002\u975e\u4e2a\u4eba\u8f6c\u8f7d\u6216\u5f15\u7528\u672c\u7f51\u7248\u6743\u6240\u6709\u5185\u5bb9\u987b\u83b7\u5f97\u6388\u6743\u5e76\u5728\u9192\u76ee\u5904\u6ce8\u660e\u201c\u8f6c\u81ea\uff1a\u201d\u3002\u6b22\u8fce\u5408\u4f5c\uff0c\u8bf7\u8054\u7cfbiddds@simm.ac.cn<\/span><\/strong><\/p>\n


<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u56fd\u5916\u836f\u7269\u7814\u53d1\u52a8\u6001 1. \u65e5\u524d\uff0c\u6b66\u7530\u5236\u836f\uff08Takeda\uff09\u9aa8\u9ad3\u7624\u836f\u7269NINLARO\u53d1\u5e03\u4e86\u7ef4\u6301\u6cbb\u7597\u8bd5\u9a8c\u7684\u79ef\u6781\u6570\u636e\u3002\u5728 […]<\/p>\n","protected":false},"author":1,"featured_media":78395,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/78394"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=78394"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/78394\/revisions"}],"predecessor-version":[{"id":78399,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/78394\/revisions\/78399"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/78395"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=78394"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=78394"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=78394"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}