{"id":79962,"date":"2019-02-17T00:00:50","date_gmt":"2019-02-26T07:58:06","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/79962\/"},"modified":"2019-02-26T15:58:07","modified_gmt":"2019-02-26T07:58:07","slug":"8379b6927a","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/79962\/","title":{"rendered":"\u5e72\u8d27 | \u5236\u5242\u8fc7\u7a0b\u4e2d\u53d1\u751f\u6676\u578b\u8f6c\u53d8\u7684\u98ce\u9669\u56e0\u7d20\u4ee5\u53ca\u673a\u5236"},"content":{"rendered":"
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1. \u7c89\u788e<\/span><\/strong><\/span><\/p>\n


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2. \u6df7\u5408\u8fc7\u7a0b<\/span><\/strong><\/span><\/p>\n

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3.\u5236\u7c92\u8fc7\u7a0b<\/span><\/strong><\/span><\/p>\n

\u5e72\u6cd5\u5236\u7c92<\/span><\/strong>\u8fc7\u7a0b\u6d89\u53ca\u5230\u673a\u68b0\u6324\u538b\u548c\u7834\u788e\u9020\u7c92\u7684\u8fc7\u7a0b\uff0c\u9700\u8981\u6ce8\u610f\u538b\u529b\u548c\u70ed\u80fd\u7b49\u56e0\u7d20\u8bf1\u5bfc\u6676\u578b\u7684\u8f6c\u53d8\u3002\u5177\u4f53\u60c5\u51b5\u53ef\u4ee5\u53c2\u7167\u7c89\u788e\u548c\u538b\u529b\u8bf1\u5bfc\u7ed3\u6676\u7684\u6848\u4f8b\u548c\u5206\u6790\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u6e7f\u6cd5\u5236\u7c92<\/span><\/strong>\u8fc7\u7a0b\u56e0\u4e3a\u8981\u4f7f\u7528\u5230\u6c34\u6216\u8005\u6eb6\u5242\uff0c\u6709\u53ef\u80fd\u9020\u6210\u6eb6\u5242\u8bf1\u5bfc\u6676\u578b\u7684\u8f6c\u53d8\uff0c\u800c\u5236\u7c92\u5e72\u71e5\u8fc7\u7a0b\u5f15\u5165\u4e86\u52a0\u70ed\u53bb\u9664\u6eb6\u5242\u7684\u64cd\u4f5c\uff0c\u4e5f\u6709\u53ef\u80fd\u9020\u6210\u6676\u578b\u7684\u8f6c\u53d8\u3002\u6bd4\u5982\u975e\u5e38\u7ecf\u5178\u7684\u6848\u4f8b\uff0c\u8336\u78b1\u5728\u6e7f\u6cd5\u5236\u7c92\u53ca\u968f\u540e\u5e72\u71e5\u8fc7\u7a0b\u4e2d\u6676\u578b\u7684\u8f6c\u53d8\u3002\u5728\u6e7f\u6cd5\u5236\u7c92\u8fc7\u7a0b\u4e2d\uff0c\u8336\u78b1\u65e0\u6c34\u7269\u53d8\u4e3a\u4e00\u6c34\u5408\u7269\u3002\u7136\u800c\u5728\u5e72\u71e5\u8fc7\u7a0b\u4e2d\u8336\u78b1\u4e00\u6c34\u5408\u7269\u53ef\u5b8c\u5168\u53d8\u56de\u65e0\u6c34\u7269\u3002<\/span><\/p>\n


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\u4ece\u4e0a\u8ff0\u4f8b\u5b50\u53ef\u4ee5\u770b\u51fa\uff0c\u5bf9\u4e8e\u521d\u59cb\u7269\u6599\u662f\u6eb6\u5242\u5408\u7269\u7684\u60c5\u51b5\uff0c\u5728\u6e7f\u6cd5\u5236\u7c92\u548c\u5e72\u71e5\u7684\u8fc7\u7a0b\u9700\u8981\u683c\u5916\u6ce8\u610f\uff0c\u6eb6\u5242\u5408\u7269\u7684\u5f62\u6210\uff0c\u8f6c\u53d8\u548c\u8131\u6eb6\u5242\u7684\u8fc7\u7a0b\u3002\u53e6\u5916\uff0c\u6e7f\u6cd5\u5236\u7c92\u8fc7\u7a0b\u4e2d\uff0c\u6eb6\u5242\u7684\u5f15\u5165\uff0c\u6709\u53ef\u80fd\u51fa\u73b0\u6eb6\u5242\u6eb6\u89e3\u6676\u578b\u836f\u7269\uff0c\u5e72\u71e5\u8fc7\u7a0b\u91cd\u7ed3\u6676\u800c\u8f6c\u53d8\u53e6\u5916\u4e00\u79cd\u6676\u578b\u3002<\/span><\/p>\n


<\/span><\/p>\n

4.\u5e72\u71e5<\/span><\/strong><\/span><\/p>\n

\u5e72\u71e5\u65f6\u7684\u6e29\u5ea6\u4e00\u822c\u8981\u8fdc\u9ad8\u4e8e\u5ba4\u6e29\uff0c\u9ad8\u6e29\u6709\u53ef\u80fd\u52a0\u901f\u8f6c\u6676\u7684\u53d1\u751f\u3002\u8981\u8b66\u60d5\u6eb6\u5242\u5408\u7269\u8131\u6eb6\u5242\u7684\u60c5\u51b5\u53d1\u751f\u3002<\/span><\/p>\n


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\u6b64\u5916\uff0c\u5e72\u71e5\u8fc7\u7a0b\uff0c\u6e29\u5ea6\u8981\u9ad8\u4e8e\u5ba4\u6e29\uff0c\u4e24\u79cd\u6e29\u5ea6\u4e4b\u95f4\u7684\u8f6c\u53d8\uff0c\u8981\u8b66\u60d5\u4e92\u53d8\u591a\u6676\u578b\u7684\u60c5\u51b5\uff0c\u6240\u8c13\u4e92\u53d8\u591a\u6676\u578b\uff0c\u5c31\u662f\u5b58\u5728\u4e00\u4e2a\u8f6c\u53d8\u6e29\u5ea6\uff0c\u5728\u8be5\u6e29\u5ea6\u70b9\u4ee5\u4e0a\u548c\u4ee5\u4e0b\uff0c\u4e24\u79cd\u6676\u578b\u7684\u7a33\u5b9a\u6027\u53d1\u751f\u8f6c\u6362\u3002\u867d\u7136\u8fd9\u79cd\u60c5\u51b5\u5728\u5236\u5242\u8fc7\u7a0b\u4e2d\u51fa\u73b0\u6682\u65f6\u6ca1\u6709\u6587\u732e\u62a5\u9053\uff0c\u4f46\u8fd8\u662f\u5e94\u8be5\u8b66\u60d5\u3002<\/span><\/p>\n


<\/span><\/p>\n

5.\u538b\u7247<\/span><\/strong><\/span><\/p>\n

\u538b\u7247\u7684\u8fc7\u7a0b\uff0c\u5bf9\u5236\u5242\u65bd\u52a0\u4e86\u538b\u529b\uff0c\u6709\u53ef\u80fd\u8bf1\u5bfc\u6676\u578b\u7684\u8f6c\u53d8\uff0c\u800c\u538b\u7247\u7684\u6301\u7eed\u8fdb\u884c\uff0c\u4e5f\u9700\u8981\u8003\u8651\u70ed\u80fd\u7684\u91ca\u653e\uff0c\u5236\u5242\u6e29\u5ea6\u7684\u4e0a\u5347\u8bf1\u5bfc\u6676\u578b\u7684\u8f6c\u53d8\u3002\u901a\u5e38\u591a\u6676\u578b\u836f\u7269\u7684\u4e9a\u7a33\u5b9a\u578b\u4e0e\u7a33\u5b9a\u578b\u5728\u538b\u529b\u4e0b\u4f1a\u76f8\u4e92\u8f6c\u53d8\uff0c\u5e76\u4e14\u968f\u7740\u538b\u529b\u7684\u589e\u5927\u6216\u538b\u7247\u6b21\u6570\u7684\u589e\u591a\u800c\u98ce\u9669\u589e\u5927\u3002\u4f8b\u5982\uff0c\u5229\u798f\u5e73\u7684\u6676\u578b\u2161\u5728\u8d85\u8fc7\u4e00\u5b9a\u538b\u529b\u65f6\u8f6c\u5316\u4e3a\u6676\u578b\u2160\u3002\u6cd5\u83ab\u66ff\u4e01\u7684\u6676\u578b B \u5728\u538b\u7247\u8fc7\u7a0b\u4e2d\u8f6c\u5316\u4e3a\u6676\u578b A\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u6b64\u5916\uff0c\u538b\u529b\u8bf1\u5bfc\u65e0\u5b9a\u5f62\u6001\u836f\u7269\u8f6c\u53d8\u6210\u6676\u578b\u836f\u7269\u4e5f\u6709\u62a5\u9053\uff0c\u9700\u8981\u5f15\u8d77\u6ce8\u610f\u3002<\/span><\/p>\n


<\/span><\/p>\n

6.\u5305\u8863<\/span><\/strong><\/span><\/p>\n


<\/p>\n

\u5305\u8863\u7684\u8fc7\u7a0b\u4e00\u822c\u6709\u6eb6\u5242\u7684\u53c2\u4e0e\uff0c\u6240\u4ee5\u6709\u53ef\u80fd\u8bf1\u5bfc\u6676\u578b\u7684\u8f6c\u53d8\uff0c\u7279\u522b\u662f\u5bf9\u4e8e\u5fae\u4e38\u7b49\uff0c\u5728\u5236\u5242\u8fc7\u7a0b\u4e2d\u5c06\u836f\u7269\u6eb6\u89e3\u540e\u4f5c\u4e3a\u5305\u8863\u5c42\uff0c\u5728\u5305\u8863\u8fc7\u7a0b\u4e2d\u6613\u53d1\u751f\u6676\u578b\u8f6c\u53d8\u3002Lust \u7b49\u5c06\u5421\u7f57\u6614\u5eb7\u6eb6\u4e8e\u6c34\u540e\u4f5c\u4e3a\u5305\u8863\u5c42\uff0c\u7ed3\u679c\u8868\u660e\uff0c\u5f53\u5421\u7f57\u6614\u5eb7\u65e0\u6c34\u7269\u548c\u4e00\u6c34\u5408\u7269\u5728\u5305\u8863\u8fc7\u7a0b\u4e2d\u6ca1\u6709\u53d1\u751f\u8f6c\u53d8\uff0c\u4f46\u662f\u5421\u7f57\u6614\u5eb7\u65e0\u5b9a\u578b\u6001\u5728\u5305\u8863\u8fc7\u7a0b\u4e2d\u5219\u8f6c\u53d8\u4e3a\u4e00\u6c34\u5408\u7269\u3002<\/span><\/p>\n


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<\/p>\n<\/section>\n<\/section>\n

\u5236\u5242\u6216\u8005\u50a8\u5b58\u8fc7\u7a0b\u4e2d\u6676\u578b\u662f\u5426\u53d1\u751f\u8f6c\u53d8\u9700\u8981\u7cfb\u7edf\u7684\u8003\u5bdf\uff0c\u5e38\u7528\u7684\u68c0\u6d4b\u6676\u578b\u8f6c\u53d8\u7684\u624b\u6bb5\u6709X\u5c04\u7ebf\u884d\u5c04\uff1b\u504f\u5149\u663e\u5fae\u955c\u6280\u672f\uff1b\u5dee\u793a\u626b\u63cf\u91cf\u70ed\u6cd5\uff1b\u7ea2\u5916\u5149\u8c31\uff1b\u62c9\u66fc\u5149\u8c31\uff1b\u56fa\u6001\u6838\u78c1\u6280\u672f\u7b49\u3002\u901a\u5e38\u4f1a\u91c7\u7528\u591a\u79cd\u624b\u6bb5\u8fdb\u884c\u68c0\u6d4b\u548c\u9274\u5b9a\u3002\u800c\u5236\u5242\u751f\u4ea7\u8fc7\u7a0b\u4e2d\u4e5f\u53ef\u8fd0\u7528\u8fc7\u7a0b\u5206\u6790\u6280\u672f\u8fdb\u884c\u6676\u578b\u7684\u5b9e\u65f6\u76d1\u63a7\uff0c\u6587\u732e\u62a5\u9053\u7684\u591a\u91c7\u7528\u8fd1\u7ea2\u5916\u5149\u8c31\u548c\u62c9\u66fc\u5149\u8c31\u8fdb\u884c\u5728\u7ebf\u76d1\u63a7\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u53c2\u8003\u6587\u732e<\/span><\/p>\n

Chan HK, Doelker E.Polymorphic transformation of some drugs under compression [J]. Drug Dev Ind Pharm, 1985, 11:315\u2212332<\/span><\/p>\n

YANNAN LIN, R. P. C.,PETER L.D. WILDFONG, Informatic Calibration of a Materials Properties Database for Predictive Assessment of Mechanically Activated Disordering Potential for Small Molecule Organic Solids. JOURNAL OF PHARMACEUTICAL SCIENCES 2008, 98 (8),2696-2708.<\/span><\/p>\n

LUST A\uff0c LAKIO S\uff0c VINTSEVITS J\uff0c et al\uff0e Water-mediated solidstate transformation of a polymorphic drug during aqueous-based drug-layer coating of pellets\uff3bJ\uff3d.Int J Pharm,2013,456(1) :41-48\uff0e<\/span><\/p>\n

\u9ad8\u6676, \u6ed5\u518d\u8fdb, \u675f\u4fed\u8f89, et al. \u56fa\u4f53\u5236\u5242\u751f\u4ea7\u8fc7\u7a0b\u4e2d\u7684\u836f\u7269\u6676\u578b\u8f6c\u53d8[J]. \u4e2d\u56fd\u65b0\u836f\u6742\u5fd7, 2018, v.27(09):36-41.<\/span><\/p>\n

\u5f20\u5947, \u6885\u96ea\u950b. \u56fa\u4f53\u836f\u7269\u7684\u8f6c\u6676\u73b0\u8c61[J]. \u836f\u5b66\u5b66\u62a5,2015(5):521-527.<\/span><\/p>\n


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\u8f6c\u81ea\uff1a<\/span><\/p>\n

\u7f16\u8f91\uff1a\u5c0f\u767d<\/span><\/p>\n

\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u5c0f\u5206\u5b50\u836f\u7269\u5206\u5b50\u6392\u5217\u65b9\u5f0f\u4e0d\u540c\u4ece\u800c\u5177\u6709\u4e0d\u540c\u7684\u6676\u578b\u3002\u4e0d\u540c\u7684\u6676\u578b\u7406\u5316\u6027\u8d28\u5177\u6709\u5dee\u5f02\uff0c\u5305\u62ec\u5bc6\u5ea6\u3001\u6eb6\u89e3\u5ea6\u3001\u53ef\u538b\u6027\u3001\u6d41\u52a8\u6027\u751a\u81f3 […]<\/p>\n","protected":false},"author":1,"featured_media":79963,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/79962"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=79962"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/79962\/revisions"}],"predecessor-version":[{"id":79967,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/79962\/revisions\/79967"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/79963"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=79962"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=79962"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=79962"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}