{"id":80807,"date":"2019-02-07T00:00:50","date_gmt":"2019-02-26T08:06:47","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/80807\/"},"modified":"2019-02-26T16:06:50","modified_gmt":"2019-02-26T08:06:50","slug":"7429a2d097","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/80807\/","title":{"rendered":"[\u9010\u6b65\u7a81\u7834]2018\u5e74\u8fd9\u4e9b\u836f\u4f01,\u6388\u6743\u4e86\u6d77\u5916\u5e02\u573a!"},"content":{"rendered":"
\n
\n
\n
\n
\n
\"[\u9010\u6b65\u7a81\u7834]2018\u5e74\u8fd9\u4e9b\u836f\u4f01,\u6388\u6743\u4e86\u6d77\u5916\u5e02\u573a!\"<\/section>\n
2018\u5e741\u67084\u65e5<\/strong><\/section>\n<\/section>\n


<\/p>\n<\/section>\n

\u6052\u745e\u533b\u836f\u5c06<\/span>JAK1<\/span>\u6291\u5236\u5242\uff08<\/span>SHR0302)<\/span>\u9879\u76ee\u90e8\u5206\u6d77\u5916\u6743\u76ca\u6709\u507f\u8bb8\u53ef\u7ed9\u7f8e\u56fd<\/span>Arcutis Inc<\/span>\u516c\u53f8\u3002<\/span>
<\/p>\n

\"[\u9010\u6b65\u7a81\u7834]2018\u5e74\u8fd9\u4e9b\u836f\u4f01,\u6388\u6743\u4e86\u6d77\u5916\u5e02\u573a!\"<\/p>\n

ArcutisInc<\/span>\u516c\u53f8\u88ab\u8bb8\u53ef\u8fdb\u884c\u7814\u53d1\u548c\u9500\u552e\u7684<\/span>SHR0302<\/span>\u5242\u578b\u8303\u56f4\u4e3a\u7528\u4e8e\u76ae\u80a4\u75be\u75c5\u6cbb\u7597\u7684\u5c40\u90e8\u5916\u7528\u5236\u5242\u3002\u6052\u745e\u6700\u591a\u53ef\u83b7\u5f97\u5171\u603b\u8ba1<\/span>2.23<\/span>\u4ebf\u7f8e\u5143\u7684\u9996<\/span><\/span><\/span>\u4ed8\u6b3e\uff08\u76f8\u5bf9\u5f88\u4f4e\uff0c200\u4e07\u7f8e\u91d1\uff09\u548c\u91cc\u7a0b\u7891\u6b3e,\u5916\u52a0\u9500\u552e\u63d0\u6210\u3002<\/span><\/p>\n


<\/p>\n

\u76f8\u5173\u91cc\u7a0b\u7891\uff08Milestone\uff09\uff1a<\/span><\/p>\n


<\/p>\n

\u5f53SHR0302\u8fdb\u5165\u7f8e\u56fdArcutis\u516c\u53f8\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u65f6,\u6052\u745e\u53ef\u83b7\u5f97300\u4e07<\/span>\u7f8e\u5143\u3002<\/span>SHR0302<\/span>\u5728\u7f8e\u56fd\u3001\u6b27\u76df\u548c\u65e5\u672c\u6210\u529f\u4e0a\u5e02\u540e<\/span>,<\/span>\u7f8e\u56fd<\/span>Arcutis<\/span>\u516c\u53f8\u5411\u6052\u745e\u652f\u4ed8\u7d2f\u8ba1\u4e0d\u8d85\u8fc7<\/span>1750<\/span>\u4e07\u7f8e\u5143\u7684\u91cc\u7a0b\u7891\u6b3e<\/span>;SHR0302<\/span>\u7684\u5e74\u9500\u552e\u989d\u8fbe\u5230\u4e0d\u540c\u7684\u76ee\u6807\u540e<\/span>,<\/span>\u7f8e\u56fd<\/span>Arcutis<\/span>\u516c\u53f8\u5411\u6052\u745e\u652f\u4ed8\u7d2f\u8ba1\u4e0d\u8d85\u8fc7<\/span>2<\/span>\u4ebf\u7f8e\u5143\u7684\u91cc\u7a0b\u7891\u6b3e\u3002<\/span><\/span><\/p>\n

\n


<\/p>\n

\n
\"[\u9010\u6b65\u7a81\u7834]2018\u5e74\u8fd9\u4e9b\u836f\u4f01,\u6388\u6743\u4e86\u6d77\u5916\u5e02\u573a!\"<\/section>\n
2018\u5e741\u67088\u65e5<\/strong><\/section>\n<\/section>\n


<\/p>\n<\/section>\n

\u6052\u745e\u533b\u836f\u5c06<\/span>BTK<\/span>\u6291\u5236\u5242<\/span>SHR-1459<\/span>\uff08<\/span>TG-1701<\/span>\uff09\u5728\u65e5\u672c\u4ee5\u53ca\u4e9a\u6d32\u4ee5\u5916\u5176\u4ed6\u5168\u90e8\u56fd\u5bb6\u548c\u5730\u533a\u7684\u5f00\u53d1\u6743\u5229\u6388\u6743<\/span>TGTherapeutics<\/span>\u3002<\/span><\/span><\/p>\n


<\/p>\n

\"[\u9010\u6b65\u7a81\u7834]2018\u5e74\u8fd9\u4e9b\u836f\u4f01,\u6388\u6743\u4e86\u6d77\u5916\u5e02\u573a!\"<\/p>\n


<\/p>\n

\u9996\u4ed8\u6b3e\uff1a<\/span>100<\/span>\u4e07\u7f8e\u5143\u3002<\/span><\/span><\/span><\/p>\n


<\/p>\n

\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff1a<\/span>3.46<\/span>\u4ebf\u7f8e\u5143\u3002<\/strong>\u5f00\u53d1\u548c\u83b7\u6279\u91cc\u7a0b\u91d1<\/span>1.862<\/span>\u4ebf\u7f8e\u5143\uff0c\u9500\u552e\u91cc\u7a0b\u91d1<\/span>1.6<\/span>\u4ebf\u7f8e\u5143\u3002<\/span><\/span><\/p>\n


<\/p>\n

\u5f53\u6bcf\u4e2a<\/span>BTK<\/span>\u6291\u5236\u5242\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u4e0d\u540c\u7684\u9636\u6bb5\u540e\u6052\u745e\u53ef\u83b7\u5f97\u7d2f\u8ba1\u4e0d\u8d85\u8fc7<\/span>710<\/span>\u4e07\u7f8e\u5143\u7684\u91cc\u7a0b\u7891\u6b3e\u6216\u540c\u7b49\u4ef7\u503c\u7684<\/span>TG<\/span>\u516c\u53f8\u80a1\u6743\uff1b<\/span><\/span><\/p>\n


<\/p>\n

\u5f53\u6bcf\u4e2a<\/span>BTK<\/span>\u6291\u5236\u5242\u548c\u5176\u5b83\u6cbb\u7597\u8840\u6db2\u80bf\u7624\u7684\u836f\u7269\u8054\u7528\u65f6\uff0c\u6216\u901a\u8fc7\u6d77\u5916\u4e34\u5e8a\u8bd5\u9a8c\u8bc1\u5b9e\u6bd4\u4f0a\u5e03\u66ff\u5c3c\u6216\u963f\u5361\u62c9\u5e03\u66ff\u5c3c\uff08<\/span>acalabrutinib<\/span>\uff09\u66f4\u52a0\u4f18\u8d8a\u65f6\uff0c\u6052\u745e\u53ef\u83b7\u5f97\u7ea6 <\/span><\/span>3800<\/span>\u4e07\u7f8e\u5143\u7684\u91cc\u7a0b\u7891\u6b3e\u6216\u540c\u7b49\u4ef7\u503c\u7684<\/span>TG<\/span>\u516c\u53f8\u80a1\u6743\uff1b<\/span><\/span><\/p>\n


<\/p>\n

\u6bcf\u4e2a<\/span>BTK<\/span>\u6291\u5236\u5242\u5728\u8bb8\u53ef\u8303\u56f4\u56fd\u5bb6\u83b7\u6279\u540e\uff0c<\/span>TG<\/span>\u516c\u53f8\u5411\u6052\u745e\u652f\u4ed8\u7d2f\u8ba1\u4e0d\u8d85\u8fc7<\/span>4800<\/span>\u4e07\u7f8e\u5143\u7684\u91cc\u7a0b\u7891\u6b3e\uff1b<\/span><\/span><\/p>\n


<\/p>\n

\u6bcf\u4e2a<\/span>BTK<\/span>\u6291\u5236\u5242\u7684\u9500\u552e\u989d\u8fbe\u5230<\/span>2.5<\/span>\u4ebf\u81f3<\/span>10<\/span>\u4ebf\u7f8e\u5143\u4ee5\u4e0a\u7684\u533a\u95f4\uff0c<\/span>TG<\/span>\u516c\u53f8\u5411\u6052\u745e\u652f\u4ed8\u7d2f\u8ba1\u4e0d\u8d85\u8fc7<\/span>8000<\/span>\u4e07\u7f8e\u5143\u7684\u91cc\u7a0b\u7891\u6b3e\uff0c\u6bcf\u4e2a\u76ee\u6807\u7684\u91d1\u989d\u8303\u56f4\u4e3a<\/span>1000<\/span>\u4e07\u7f8e\u5143\u81f3<\/span>5000<\/span>\u4e07\u7f8e\u5143\u3002<\/span><\/span><\/p>\n


<\/p>\n

\u9500\u552e\u63d0\u6210\uff1a\u6bcf\u4e2a<\/span>BTK<\/span>\u6291\u5236\u5242\u5728\u56fd\u5916\u4e0a\u5e02\u540e\uff0c\u6052\u745e\u6309\u7167\u7ea6\u5b9a\u6bd4\u4f8b\u4ece\u5176\u9500\u552e\u989d\u4e2d\u83b7\u53d6\u63d0\u6210\u3002\u63d0\u6210\u6bd4\u4f8b\u8303\u56f4\u4e3a<\/span>10%~12%<\/span>\u3002<\/span><\/span><\/p>\n

\n


<\/p>\n

\n
\"[\u9010\u6b65\u7a81\u7834]2018\u5e74\u8fd9\u4e9b\u836f\u4f01,\u6388\u6743\u4e86\u6d77\u5916\u5e02\u573a!\"<\/section>\n
2018\u5e746\u670821\u65e5<\/strong><\/section>\n<\/section>\n


<\/p>\n<\/section>\n

\u4e0a\u6d77\u590d\u5b8f\u6c49\u9716\u751f\u7269\u4e0e\u82f1\u56fd<\/span>AccordHealthcare Limited<\/span>\uff08<\/span>Intas<\/span>\u5b50\u516c\u53f8\uff09\u6b63\u5f0f\u7b7e\u8ba2\u300a<\/span>LicenseAgreement<\/span><\/span>\u300b\u3002\u590d\u5b8f\u6c49\u9716\u6388\u6743<\/span>Accord<\/span>\u5728\u533a\u57df\u5185\uff08\u5373\u6b27\u6d32\u5730\u533a\u5305\u62ec\u82f1\u56fd\u3001\u6cd5\u56fd\u7b49<\/span>53<\/span>\u4e2a\u56fd\u5bb6\uff0c\u4e2d\u4e1c\u53ca\u5317\u975e\u5730\u533a\u5305\u62ec\u6c99\u7279\u963f\u62c9\u4f2f\u3001\u963f\u62c9\u4f2f\u8054\u5408\u914b\u957f\u56fd\u7b49<\/span>17<\/span>\u4e2a\u56fd\u5bb6\u548c\u90e8\u5206\u72ec\u8054\u4f53\u56fd\u5bb6\uff09\u5bf9\u590d\u5b8f\u6c49\u9716\u81ea\u4e3b\u7814\u53d1\u7684<\/span>HLX02<\/span>\uff08\u6ce8\u5c04\u7528\u91cd\u7ec4\u6297<\/span>HER2<\/span>\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\uff0c\u66f2\u59a5\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff09\u8fdb\u884c\u72ec\u5bb6\u5546\u4e1a\u5316\u8bb8\u53ef\uff08\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u9500\u552e\u3001\u8981\u7ea6\u51fa\u552e\u3001\u8fdb\u53e3\u3001\u5206\u9500\u53ca\u5176\u4ed6\u5546\u4e1a\u5316\u884c\u4e3a\uff09\u3002<\/span>HLX02<\/span><\/span>\u6b63\u5728\u5f00\u5c55\u56fd\u9645\u591a\u4e2d\u5fc3<\/span>III<\/span>\u671f\u4e34\u5e8a\u7814\u7a76\u3002<\/span><\/span><\/p>\n

\"[\u9010\u6b65\u7a81\u7834]2018\u5e74\u8fd9\u4e9b\u836f\u4f01,\u6388\u6743\u4e86\u6d77\u5916\u5e02\u573a!\"<\/p>\n

\u6b64\u6b21\u5408\u4f5c\u7684\u8fbe\u6210\u662f\u590d\u5b8f\u6c49\u9716\u79ef\u6781\u63a8\u8fdb\u56fd\u9645\u5316\u5e03\u5c40\u3001\u52a0\u5feb\u56fd\u9645\u5316\u6218\u7565\u6b65\u4f10\u7684\u91cd\u8981\u4e3e\u63aa\u3002<\/span>Accord<\/span>\u5c06\u901a\u8fc7\u5176\u8986\u76d6\u5168\u7403\u7684\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u7f51\u7edc\u4e3a\u8be5\u4ea7\u54c1\u7684\u6d77\u5916\u5e02\u573a\u4e1a\u52a1\u5e26\u6765\u5148\u53d1\u4f18\u52bf\uff0c\u52a0\u5feb\u8be5\u4ea7\u54c1\u6d77\u5916\u5e02\u573a\u7684\u5f00\u62d3\u3002<\/span><\/span><\/p>\n

\n
\n
\"[\u9010\u6b65\u7a81\u7834]2018\u5e74\u8fd9\u4e9b\u836f\u4f01,\u6388\u6743\u4e86\u6d77\u5916\u5e02\u573a!\"<\/section>\n
2018\u5e747\u670826\u65e5<\/strong><\/section>\n<\/section>\n


<\/p>\n<\/section>\n

\u5929\u5883\u751f\u7269\u4e0e\u97e9\u56fd\u751f\u7269\u6280\u672f\u516c\u53f8<\/span>ABLBio<\/span>\u8054\u5408\u5ba3\u5e03\u53cc\u65b9\u5efa\u7acb\u5168\u7403\u6218\u7565\u5408\u4f5c\u5173\u7cfb\u3002<\/span>ABLBio<\/span>\u5c06\u83b7\u5f97\u5929\u5883\u4e00\u4e2a\u53cc\u7279\u5f02\u6027\u6297\u4f53\uff08<\/span>BsAb<\/span>\uff09\u9879\u76ee\u9664\u5927\u4e2d\u534e\u5730\u533a\u4ee5\u5916\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u6743\u76ca\uff0c<\/span>ABLBio<\/span>\u5c06\u4e3a\u6b64\u652f\u4ed8\u9ad8\u8fbe\u5927\u7ea6<\/span>1<\/span>\u4ebf\u7f8e\u5143\u7684\u603b\u6388\u6743\u91d1\u989d\u3002<\/span><\/span><\/p>\n


<\/p>\n

      <\/span><\/span>\"[\u9010\u6b65\u7a81\u7834]2018\u5e74\u8fd9\u4e9b\u836f\u4f01,\u6388\u6743\u4e86\u6d77\u5916\u5e02\u573a!\"<\/p>\n


<\/p>\n

\u6839\u636e\u5408\u4f5c\u534f\u8bae\u6761\u6b3e\uff0c<\/span>ABLBio<\/span>\u5c06\u652f\u4ed8\u7ed9\u5929\u5883<\/span>250<\/span>\u4e07\u7f8e\u5143\u7684\u9884\u4ed8\u6b3e\u3002\u5929\u5883\u8fd8\u5c06\u4ece<\/span>ABLBio<\/span><\/span>\u83b7\u5f97\u7814\u53d1\u3001\u6ce8\u518c\u548c\u9500\u552e\u7684\u91cc\u7a0b\u7891\u5f0f\u4ed8\u6b3e\uff0c\u603b\u91d1\u989d\u5c06\u9ad8\u8fbe<\/span>1<\/span>\u4ebf\u7f8e\u5143\u3002\u6b64\u5916\uff0c<\/span>ABLBio<\/span>\u8fd8\u5c06\u652f\u4ed8\u57fa\u4e8e\u51c0\u9500\u552e\u6536\u5165\u7684\u68af\u5ea6\u63d0\u6210\u3002\u672c\u6b21\u5408\u4f5c\u8fd8\u5c06\u5305\u62ec\u53e6\u5916\u4e09\u4e2a\u53cc\u7279\u5f02\u6027\u6297\u4f53\u9879\u76ee\u3002\u5929\u5883\u548c<\/span>ABLBio<\/span>\u5c06\u5728\u4e2d\u56fd\u3001\u97e9\u56fd\u53ca\u5168\u7403\u5176\u4ed6\u5730\u533a\u4ee5\u4e0d\u540c\u5f62\u5f0f\u5171\u540c\u5206\u62c5\u7814\u53d1\u8d39\u7528\u5e76\u5171\u4eab\u4ea7\u54c1\u6743\u76ca\u3002<\/span><\/span><\/p>\n

\n


<\/p>\n

\n
\"[\u9010\u6b65\u7a81\u7834]2018\u5e74\u8fd9\u4e9b\u836f\u4f01,\u6388\u6743\u4e86\u6d77\u5916\u5e02\u573a!\"<\/section>\n
2018\u5e748\u670821\u65e5<\/strong><\/section>\n<\/section>\n


<\/p>\n<\/section>\n

\u548c\u94c2\u533b\u836f\uff08<\/span>HarbourBioMed<\/span>\uff09\u4e0e\u79d1\u4f26\u535a\u6cf0\u5ba3\u5e03\u5f00\u5c55\u5168\u7403\u6218\u7565\u5408\u4f5c\uff0c\u548c\u94c2\u533b\u836f\u5c06\u83b7\u5f97\u79d1\u4f26\u535a\u6cf0\u5904\u4e8e\u4e34\u5e8a\u4e8c\u671f\u9636\u6bb5\u7684<\/span>PD-L1<\/span>\u6297\u4f53\u836f\u7269<\/span>A167<\/span>\u5728\u5168\u7403<\/span>\uff08\u9664\u5927\u4e2d\u534e\u5730\u533a\u4ee5\u5916\uff09<\/span>\u7684\u72ec\u5bb6\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u5546\u4e1a\u5316\u8bb8\u53ef\u3002\u6b64\u9879\u534f\u8bae\u6f5c\u5728\u4ef7\u503c\u8d85\u8fc7<\/span><\/span>3.5<\/span>\u4ebf\u7f8e\u5143\u4ee5\u53ca\u9500\u552e\u63d0\u6210\u3002\u540c\u65f6\uff0c\u53cc\u65b9\u8fd8\u5c31\u5728\u5168\u7403\u8303\u56f4\u5185<\/span>A167<\/span>\u548c\u5176\u4ed6\u836f\u7269\u7684\u8054\u5408\u7528\u836f\u7684\u5f00\u53d1\u8fbe\u6210\u534f\u8bae\uff1b\u53cc\u65b9\u5c06\u8bb8\u53ef\u5bf9\u65b9\u5728\u5404\u81ea\u533a\u57df\u5185\u975e\u7ade\u4e89\u6027\u7684\u3001\u4e0e<\/span>A167<\/span>\u8054\u5408\u7528\u836f\u7684\u5f00\u53d1\u6743\u5229\u3002<\/span><\/span><\/p>\n

\n


<\/p>\n

\n
\"[\u9010\u6b65\u7a81\u7834]2018\u5e74\u8fd9\u4e9b\u836f\u4f01,\u6388\u6743\u4e86\u6d77\u5916\u5e02\u573a!\"<\/section>\n
2018\u5e749\u67086\u65e5<\/strong><\/section>\n<\/section>\n


<\/p>\n<\/section>\n

\u5929\u58eb\u529b\u533b\u836f\u4e0e\u7f8e\u56fd\u5236\u836f\u4f01\u4e1a<\/span>ArborPharmaceuticals,Inc.<\/span>\u5ba3\u5e03\uff0c\u5c31<\/span>T89<\/span>\uff08\u590d\u65b9\u4e39\u53c2\u6ef4\u4e38\uff09\u5728\u7f8e\u56fd\u7684\u7814\u53d1\u4e0e\u5e02\u573a\u9500\u552e\u5c55\u5f00\u5168\u9762\u5408\u4f5c\u3002\u6839\u636e\u534f\u8bae\uff0c<\/span>Arbor<\/span>\u516c\u53f8\u5c06\u51fa\u8d44\u6700\u9ad8<\/span>2300<\/span>\u4e07\u7f8e\u91d1\u7684\u7814\u53d1\u4ed8\u6b3e\uff0c\u4e0e\u5929\u58eb\u529b\u65b9\u5171\u540c\u8fdb\u884c<\/span>T89<\/span><\/span>\u7f8e\u56fd<\/span>FDA<\/span>\u76f8\u5173\u4e34\u5e8a\u5f00\u53d1\u7814\u7a76\u548c\u836f\u653f\u7533\u62a5\uff1b\u540c\u65f6\u83b7\u5f97<\/span>T89<\/span>\u76f8\u5173\u9002\u5e94\u75c7\u5728\u7f8e\u56fd\u672c\u571f\u7684\u72ec\u5bb6\u9500\u552e\u6743\uff0c\u5929\u58eb\u529b\u65b9\u5728\u836f\u54c1\u4e0a\u5e02\u540e\u53ef\u83b7\u5f97\u6700\u9ad8<\/span>5000<\/span>\u4e07\u7f8e\u91d1\u7684\u9500\u552e\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u4ee5\u53ca\u6700\u9ad8\u53ef\u8fbe\u6bdb\u5229<\/span>50%<\/span>\u7684\u9500\u552e\u5206\u6210\u3002<\/span><\/span><\/p>\n


<\/p>\n

\"[\u9010\u6b65\u7a81\u7834]2018\u5e74\u8fd9\u4e9b\u836f\u4f01,\u6388\u6743\u4e86\u6d77\u5916\u5e02\u573a!\"<\/p>\n


<\/p>\n

\u201c\u57fa\u4e8e\u6211\u4eec\u5bf9\u4e8e<\/span>T89<\/span>\u4e34\u5e8a\u7814\u53d1\u6570\u636e\u7814\u7a76\u663e\u793a\uff0c\u8981\u5f00\u5c55\u7684<\/span>FDA<\/span>\u4e09\u671f\u9a8c\u8bc1\u6027\u8bd5\u9a8c\u5e94\u8be5\u4f1a\u6210\u529f\u3002\u201d<\/span>Arbor<\/span>\u516c\u53f8\u4e1a\u52a1\u53d1\u5c55\u526f\u603b\u88c1<\/span>BrianK.Adams<\/span>\u8868\u793a\uff1a\u201c\u5728\u6570\u767e\u540d\u60a3\u8005\u8fdb\u884c\u7684\u5148\u524d\u7814\u7a76\u8868\u660e\uff0c<\/span>T89<\/span>\u5177\u6709\u826f\u597d\u7684\u6297\u5fc3\u7ede\u75db\u7279\u6027\uff0c\u5982\u679c\u83b7\u5f97\u6279\u51c6\uff0c\u6211\u4eec\u76f8\u4fe1\u4e00\u4e9b\u5fc3\u810f\u75c5\u4e13\u5bb6\u4f1a\u66f4\u559c\u6b22\u5929\u7136\u690d\u7269\u6cbb\u7597\u7684\u9009\u62e9\u3002\u201d<\/span><\/span><\/p>\n


<\/p>\n

\n
\n
\"[\u9010\u6b65\u7a81\u7834]2018\u5e74\u8fd9\u4e9b\u836f\u4f01,\u6388\u6743\u4e86\u6d77\u5916\u5e02\u573a!\"<\/section>\n
2018\u5e7411\u670827\u65e5<\/strong><\/section>\n<\/section>\n


<\/p>\n<\/section>\n


<\/p>\n

\"[\u9010\u6b65\u7a81\u7834]2018\u5e74\u8fd9\u4e9b\u836f\u4f01,\u6388\u6743\u4e86\u6d77\u5916\u5e02\u573a!\"<\/p>\n


<\/p>\n

Theagreement provides Hikma with exclusive rights to market a suite ofHansoh\u2019s injectable oncology medicines within the US for the nextfive years. Hansoh expects to file these products for approval withthe FDA within the next 12 months. <\/span>\uff08\u8c6a\u68ee\u7684\u6297\u80bf\u7624\u836f\u7269\u672a\u6765<\/span>5<\/span>\u5e74\u7f8e\u56fd\u5e02\u573a\u72ec\u5bb6\u9500\u552e\u6743\uff09<\/span>
<\/p>\n

\u201cOurpartnership with Hansoh will expand Hikma\u2019s growing US portfolio ofvital injectable oncology medicines and strengthens our ability toserve the growing needs of US hospitals, physicians and patients\u201d .<\/span><\/span><\/p>\n


<\/p>\n

\n
\n
\"[\u9010\u6b65\u7a81\u7834]2018\u5e74\u8fd9\u4e9b\u836f\u4f01,\u6388\u6743\u4e86\u6d77\u5916\u5e02\u573a!\"<\/section>\n
2018\u5e7411\u670827\u65e5<\/strong><\/section>\n<\/section>\n


<\/p>\n<\/section>\n

 CBTPharmaceuticals(CBT)<\/span>\uff08\u5df2\u6539\u540d\u4e3a<\/span>ApollomicsPharmaceuticals<\/span>\uff09\u548c\u6d59\u6c5f\u535a\u751f\u533b\u836f\u5ba3\u5e03\uff0c\u53cc\u65b9\u5df2\u7b7e\u8ba2\u4e34\u5e8a\u5408\u4f5c\u548c\u8bb8\u53ef\u534f\u8bae\u3002\u8be5\u8bb8\u53ef\u534f\u8bae\u6388\u4e88<\/span>CBT<\/span>\u5728<\/span>\u5927\u4e2d\u534e\u5730\u533a\u4ee5\u5916\u7684\u5168\u7403\u5730\u533a<\/span>\u4eab\u6709\u535a\u751f\u533b\u836f\u7684<\/span><\/span>ES-072<\/span>\u72ec\u5bb6\u6743\u5229\uff0c\u53ef\u8054\u5408<\/span>CBT<\/span>\u81ea\u6709\u7684<\/span>c-Met<\/span>\u6291\u5236\u5242<\/span>(CBT-101)<\/span>\u548c\u6297<\/span>PD-1<\/span>\u6297\u4f53<\/span>(CBT-501)<\/span>\uff0c\u5bf9<\/span>Bossan<\/span>\u7684\u65b0\u578b\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53<\/span>(<\/span>\u4e09\u4ee3<\/span>EGFR)<\/span>\u6291\u5236\u5242<\/span>ES-072<\/span><\/span>\u8fdb\u884c\u7814\u53d1\u548c\u5546\u4e1a\u5316\u3002<\/span><\/span><\/p>\n

\n
\n
\"[\u9010\u6b65\u7a81\u7834]2018\u5e74\u8fd9\u4e9b\u836f\u4f01,\u6388\u6743\u4e86\u6d77\u5916\u5e02\u573a!\"<\/section>\n
2018\u5e7411\u670830\u65e5<\/strong><\/section>\n<\/section>\n


<\/p>\n<\/section>\n

\u5929\u5883\u751f\u7269\u4e0e\u7f8e\u56fd<\/span>TRACONPharmaceuticals\uff08\u7eb3\u65af\u8fbe\u514b\u80a1\u7968\u4ee3\u7801\uff1a<\/span>TCON\uff09\uff0c\u8054\u5408\u5ba3\u5e03\u53cc\u65b9\u8fbe\u6210\u6218\u7565\u5408\u4f5c\u4f19\u4f34\u5173\u7cfb\uff0c\u5171\u540c\u5f00\u53d1\u5929\u5883\u751f\u7269\u62e5\u6709\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684<\/span>CD73\u6297\u4f53<\/span>TJD5<\/span>\u53ca\u672a\u6765\u6570\u4e2a\u53cc\u7279\u5f02\u6027\u6297\u4f53\u3002 <\/span><\/span><\/p>\n


<\/p>\n

\u5728\u6b64\u534f\u8bae\u4e0b\uff0c<\/span>TRACON\u5c06\u8d1f\u8d23\u6267\u884c<\/span>TJD5\u53ca\u6570\u4e2a\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5728\u7f8e\u56fd\u53ca\u5176\u4ed6\u5317\u7f8e\u5730\u533a\u7684\u4e34\u5e8a\u8bd5\u9a8c\u548c\u6ce8\u518c\u5de5\u4f5c\uff0c\u5e76\u5c06\u72ec\u81ea\u627f\u62c5\u5728\u6b64\u5730\u533a\u521d\u671f\u4e34\u5e8a\u5f00\u53d1\u7684\u6240\u6709\u8d39\u7528\uff0c\u540e\u671f\u4e34\u5e8a\u7684\u7814\u7a76\u548c\u5546\u4e1a\u5316\u8d39\u7528\u5219\u4e0e\u5929\u5883\u751f\u7269\u5206\u644a\u3002\u53e6\u5916\uff0c<\/span>TRACON\u5c06\u4e0e\u5929\u5883\u751f\u7269\u5206\u4eab\u7531\u53cc\u65b9\u5171\u540c\u5f00\u53d1\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\u5728\u5317\u7f8e\u5730\u533a\u7684\u6743\u5229\uff0c\u5e76\u53ef\u5728\u67d0\u4e9b\u5176\u4ed6\u5730\u533a\u4ece\u5929\u5883\u751f\u7269\u6388\u6743\u5f15\u8fdb\u8fd9\u4e9b\u53cc\u7279\u5f02\u6027\u6297\u4f53\u3002<\/span><\/span> <\/span><\/p>\n


<\/p>\n

\u5173\u4e8e<\/span>TJD5<\/span><\/p>\n


<\/p>\n

TJD5\u662f\u4e00\u4e2a\u9488\u5bf9<\/span>CD73\u9776\u70b9\u7684\u521b\u65b0\u4eba\u6e90\u5316\u6297\u4f53\u3002<\/span>CD73\u662f\u80de\u5916<\/span>-5\u2018-\u6838\u82f7\u9178\u9176\uff0c\u5e7f\u6cdb\u8868\u8fbe\u5728\u57fa\u8d28\u5185\u76ae\u7ec6\u80de\u548c\u80bf\u7624\u7ec6\u80de\u8868\u9762\uff0c\u6c34\u89e3\u73af\u5883\u4e2d\u7684\u5355\u78f7\u9178\u817a\u82f7\u8131\u53bb\u78f7\u9178\u57fa\u56e2\uff0c\u5728\u80bf\u7624\u73af\u5883\u5185\u4ea7\u751f\u5927\u91cf\u5177\u6709\u6291\u5236\u514d\u75ab\u529f\u80fd\u7684\u817a\u82f7\u5206\u5b50\u3002\u901a\u8fc7\u7ed3\u5408<\/span>CD73\u53cc\u805a\u4f53\u5206\u5b50\u7684\u4e00\u4e2a\u5168\u65b0\u6297\u539f\u8868\u4f4d\uff0c<\/span>TJ-D5\u80fd\u591f\u4ee5\u975e\u5e95\u7269\u7ade\u4e89\u7684\u65b9\u5f0f\u6709\u6548\u6291\u5236<\/span>CD73\u7684\u9176\u6d3b\u53cd\u5e94\uff0c\u964d\u4f4e\u817a\u82f7\u7684\u4ea7\u751f\uff0c\u4fc3\u8fdb<\/span>T\u7ec6\u80de\u6d3b\u6027\u53ca\u80bf\u7624\u6291\u5236\u6548\u679c\u3002<\/span><\/span><\/p>\n


<\/p>\n

\u9644<\/strong><\/p>\n


<\/p>\n

\n
\n
\n
\n
\"[\u9010\u6b65\u7a81\u7834]2018\u5e74\u8fd9\u4e9b\u836f\u4f01,\u6388\u6743\u4e86\u6d77\u5916\u5e02\u573a!\"<\/section>\n
\n

2019<\/strong>\u5e74<\/strong>1<\/strong>\u6708<\/strong>15<\/strong>\u65e5<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\n


<\/p>\n<\/section>\n<\/section>\n

\u767e\u5965\u6cf0\u4e0e<\/span>Cipla\u7b7e\u8ba2\u6297\u80bf\u7624\u836f\u7269\u6388\u6743\u8bb8\u53ef\u53ca\u5546\u4e1a\u5316\u534f\u8bae<\/span><\/span><\/p>\n


<\/p>\n

   \"[\u9010\u6b65\u7a81\u7834]2018\u5e74\u8fd9\u4e9b\u836f\u4f01,\u6388\u6743\u4e86\u6d77\u5916\u5e02\u573a!\"<\/span><\/p>\n


<\/p>\n

\u6839\u636e\u534f\u8bae\uff0c\u767e\u5965\u6cf0\u5c06\u8d1f\u8d23\u6297\u80bf\u7624\u836f\u7269<\/span>BAT1706\u7684\u4ea7\u54c1\uff08\u8d1d\u4f10\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff09<\/span>\u5f00\u53d1\u53ca\u5546\u4e1a\u5316\u4ea7\u54c1\u4f9b\u5e94\u3002<\/span>Cipla\u5c06\u51ed\u501f\u5176\u5e7f\u6cdb\u7684\u5e02\u573a\u4e0e\u9500\u552e\u4f53\u7cfb\uff0c\u5c06<\/span>BAT1706\u9500\u5f80\u591a\u4e2a\u65b0\u5174\u56fd\u5bb6\u5e02\u573a\u3002\u767e\u5965\u6cf0\u5c06\u4ece<\/span>Cipla\u83b7\u5f97\u9996\u4ed8\u6b3e\u3001\u5f00\u53d1\u91cc\u7a0b\u7891\u548c\u5546\u4e1a\u5316\u91cc\u7a0b\u7891\u4ed8\u6b3e\uff0c\u4ee5\u53ca\u9500\u552e\u5206\u6210\u3002<\/span><\/span><\/p>\n


<\/p>\n

 BAT1706\u662f\u767e\u5965\u6cf0\u6839\u636e\u4e2d\u56fd<\/span>NMPA\u3001\u7f8e\u56fd<\/span>FDA\u3001\u6b27\u6d32<\/span>EMA\u7684\u76f8\u5173\u6307\u5bfc\u539f\u5219\u5f00\u53d1\u7684\u8d1d\u4f10\u73e0\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\u3002\u8d1d\u4f10\u73e0\u5355\u6297\u5df2\u5728\u5168\u7403\u83b7\u6279<\/span>6\u79cd\u9002\u5e94\u75c7\uff0c\u5305\u62ec\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u3001\u590d\u53d1\u6027\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u3001\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u80be\u7ec6\u80de\u764c\u3001\u5bab\u9888\u764c\u3001\u5375\u5de2\u764c\u3002\u76ee\u524d\uff0c<\/span>BAT1706\u6b63\u5728\u5f00\u5c55\u6cbb\u7597\u665a\u671f\u975e\u9cde\u72b6\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u5168\u7403\u591a\u4e2d\u5fc3\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08<\/span>NCT03329911\uff09\u3002<\/span><\/span><\/p>\n


<\/p>\n

\u53c2\u8003\uff1a<\/span><\/p>\n

NMPA\/CDE\uff1b<\/span><\/span><\/p>\n

\u836f\u878d\u6570\u636e\uff0c<\/span>Pharnex Datamonitor;<\/span><\/p>\n

FDA\/EMA\uff1b<\/span><\/span><\/p>\n

\u76f8\u5173\u516c\u53f8\u516c\u5f00\u62ab\u9732\u7b49\u3002<\/span><\/p>\n


<\/p>\n<\/section>\n<\/section>\n

\u66f4\u591a\u4fe1\u606f\uff0c\u626b\u7801\uff01<\/span><\/strong><\/p>\n

\"[\u9010\u6b65\u7a81\u7834]2018\u5e74\u8fd9\u4e9b\u836f\u4f01,\u6388\u6743\u4e86\u6d77\u5916\u5e02\u573a!\"<\/p>\n


<\/p>\n

\n


<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

2018\u5e741\u67084\u65e5 \u6052\u745e\u533b\u836f\u5c06JAK1\u6291\u5236\u5242\uff08SHR0302)\u9879\u76ee\u90e8\u5206\u6d77\u5916\u6743\u76ca\u6709\u507f\u8bb8\u53ef\u7ed9\u7f8e\u56fdArcutis I […]<\/p>\n","protected":false},"author":1,"featured_media":80808,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/80807"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=80807"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/80807\/revisions"}],"predecessor-version":[{"id":80827,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/80807\/revisions\/80827"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/80808"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=80807"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=80807"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=80807"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}