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style=\"box-sizing: border-box;padding-bottom: 28px;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">\u56fd\u7acb\u764c\u75c7\u7814\u7a76\u4e2d\u5fc3\u81f4\u529b\u4e8e\u764c\u75c7\u7684\u9632\u63a7\uff0c\u8de8\u754c\u63a2\u8ba8\u76f8\u5173\u7814\u7a76\u8bfe\u9898\uff0c\u65e8\u5728\u4e3a\u6240\u6709\u764c\u75c7\u60a3\u8005\u53ca\u5176\u5bb6\u5ead\u63d0\u4f9b\u5145\u6ee1\u5e0c\u671b\u7684\u533b\u7597\u89e3\u51b3\u65b9\u6848\u3002<\/p>\n<p style=\"box-sizing: border-box;padding-bottom: 28px;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">*1 \u5c06\u6240\u9700\u7684\u836f\u7269\u5728\u5fc5\u8981\u7684\u65f6\u95f4\u9001\u8fbe\u6240\u9700\u90e8\u4f4d\u7684\u6280\u672f\u3002<\/p>\n<p style=\"box-sizing: border-box;padding-bottom: 28px;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">*2 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0px;border-style: initial;border-color: initial;list-style: none;\">*4 \u9488\u5bf9\u5375\u5de2\u764c\u7b49\u764c\u75c7\u7684\u6297\u764c\u5242\uff08Topotecan\u6258\u6cca\u66ff\u5eb7\uff09\u5305\u88f9\u5728\u5bcc\u58eb\u80f6\u7247\u81ea\u4e3b\u7814\u53d1\u7684\u8102\u8d28\u4f53\u5185\u7684\u8102\u8d28\u4f53\u5236\u5242\u3002<\/p>\n<p style=\"box-sizing: border-box;padding-bottom: 28px;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">*5 \u968f\u7740\u764c\u7ec4\u7ec7\u7684\u589e\u751f\uff0c\u5468\u56f4\u7684\u8840\u7ba1\u4f1a\u751f\u957f\uff0c\u4f46\u65b0\u751f\u7684\u8840\u7ba1\u5c1a\u4e0d\u6210\u719f\uff0c\u4f1a\u6709\u6b63\u5e38\u8840\u7ba1\u4e2d\u6ca1\u6709\u7684\u8840\u7ba1\u58c1\u95f4\u9699\u3002\u5f53\u8102\u8d28\u4f53\u3001\u9ad8\u5206\u5b50\u7b49\u6ede\u7559\u8840\u6db2\u4e2d\u65f6\uff0c\u4e0d\u4f1a\u900f\u8fc7\u6ca1\u6709\u95f4\u9699\u7684\u6b63\u5e38\u8840\u7ba1\u58c1\uff0c\u53ea\u5728\u764c\u7ec4\u7ec7\u5468\u56f4\u900f\u8fc7\u8840\u7ba1\u58c1\u3002\u6b64\u5916\uff0c\u7531\u4e8e\u764c\u7ec4\u7ec7\u4e2d\u6dcb\u5df4\u7ec4\u7ec7\u5c1a\u672a\u6210\u719f\uff0c\u5f88\u96be\u6392\u9664\u5df2\u900f\u8fc7\u7684\u8102\u8d28\u4f53\u6216\u9ad8\u5206\u5b50\u7b49\u7269\u8d28\uff0c\u56e0\u6b64\uff0c\u5b83\u4eec\u4f1a\u5411\u764c\u7ec4\u7ec7\u96c6\u805a\uff0c\u5373EPR\u6548\u5e94\uff08enhanced permeability and retention\u5b9e\u4f53\u7624\u7684\u9ad8\u901a\u900f\u6027\u548c\u6ede\u7559\u6548\u5e94\uff09\u3002<\/p>\n<p style=\"box-sizing: border-box;padding-bottom: 28px;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">*6 \u5bf9\u57fa\u56e0\u3001\u86cb\u767d\u8d28\u3001\u4ee3\u8c22\u7b49\u751f\u4f53\u5206\u5b50\u4fe1\u606f\u8fdb\u884c\u7efc\u5408\u5206\u6790\u7684\u65b9\u6cd5\u3002<\/p>\n<p style=\"box-sizing: border-box;padding-bottom: 28px;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">*7 \u63a7\u5236\u514d\u75ab\u53cd\u5e94\u5e76\u5177\u6709\u63a7\u5236\u80fd\u529b\u7684T\u7ec6\u80de\u7684\u4e00\u79cd\uff0c\u4e3b\u8981\u5bf9\u8fc7\u5269\u7684\u514d\u75ab\u53cd\u5e94\u8fdb\u884c\u6291\u5236\u3002<\/p>\n<p style=\"box-sizing: border-box;padding-bottom: 28px;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">*8 \u8d77\u6392\u9664\u5f02\u5e38\u7ec6\u80de\uff0c\u6291\u5236\u764c\u7684\u4f5c\u7528\u3002<\/p>\n<p style=\"box-sizing: border-box;padding-bottom: 28px;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\">*9 \u8d77\u6291\u5236\u514d\u75ab\u53cd\u5e94\u7684\u4f5c\u7528\u3002<\/p>\n<p style=\"box-sizing: border-box;padding-bottom: 28px;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\"><span style=\"box-sizing: border-box;font-weight: bolder;\">\u65b0\u95fb\u80cc\u666f\uff1a<\/span><\/p>\n<p style=\"box-sizing: border-box;padding-bottom: 28px;border-width: 0px;border-style: initial;border-color: initial;list-style: none;\"><span style=\"box-sizing: border-box;font-weight: bolder;\">\u5bcc\u58eb\u80f6\u7247\u96c6\u56e2\uff1a<\/span>\u7531\u5bcc\u58eb\u80f6\u7247\u682a\u5f0f\u4f1a\u793e\u3001\u5bcc\u58eb\u65bd\u4e50\u682a\u5f0f\u4f1a\u793e\u3001\u5bcc\u5c71\u5316\u5b66\u5de5\u4e1a\u682a\u5f0f\u4f1a\u793e\u7b49\u4e09\u5927\u4e8b\u4e1a\u516c\u53f8\u7ec4\u6210\uff0c\u5168\u7403\u8054\u7ed3\u5b50\u516c\u53f8\u8fbe283\u5bb6\uff0c\u5458\u5de57.7\u4e07\u4f59\u540d\uff0c 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