{"id":82060,"date":"2019-03-21T00:00:50","date_gmt":"2019-04-11T06:56:43","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/82060\/"},"modified":"2019-04-11T14:56:44","modified_gmt":"2019-04-11T06:56:44","slug":"62710f89e1","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/82060\/","title":{"rendered":"\u3010\u91cc\u7a0b\u7891\u3011\u9996\u4e2aTCR- T \u7ec6\u80de\u6ce8\u5c04\u6db2\u5728\u56fd\u5185\u83b7\u51c6\u4e34\u5e8a\uff01"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p><strong>&nbsp; &nbsp; &nbsp; &nbsp;\u6839\u636e\u836f\u878d\u6570\u636e\uff0cPharnex Datamonitor\uff0c2019\u5e743\u670820\u65e5\u663e\u793a\uff1a<\/strong><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;\">\n<p style=\"text-align: center;\"><br  \/><\/p>\n<p>CXSL1800128\uff0cTAEST16001\u6ce8\u5c04\u6db2\uff0c\u6765\u81ea\u5e7f\u4e1c\u9999\u96ea\u7cbe\u51c6\u533b\u7597\u6280\u672f\u6709\u9650\u516c\u53f8\uff1b\u83b7NMPA\u7528\u4e8e\u6cbb\u7597\u7ec4\u7ec7\u57fa\u56e0\u578b\u4e3aHLA-A*02:01\uff0c\u80bf\u7624\u6297\u539fNY-ESO-1\u8868\u8fbe\u4e3a\u9633\u6027\u7684\u8f6f\u7ec4\u7ec7\u8089\u7624\u3002<span style=\"color: rgb(0, 122, 170);\">\u610f\u5473\u7740\uff0c\u9996\u4e2aTCR- T \u7ec6\u80de\u6ce8\u5c04\u6db2\u5728\u56fd\u5185\u83b7\u51c6\u4e34\u5e8a\uff01<\/span><\/p>\n<p><br  \/><\/p>\n<p class=\"p9\" style=\"box-sizing: border-box;margin-top: 16px;margin-bottom: 18px;border-width: 0px;border-style: initial;border-color: initial;font-variant-numeric: inherit;font-variant-east-asian: inherit;font-weight: bold;font-stretch: inherit;font-size: 16px;line-height: 25px;font-family: initial;vertical-align: baseline;word-break: break-all;color: rgb(0, 0, 0);text-align: start;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 32px;\">TAEST16001&nbsp;<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">\u6ce8\u5c04\u6db2\u7814\u53d1\u60c5\u51b5<\/span><\/p>\n<p class=\"p9\" style=\"box-sizing: border-box;margin-top: 16px;margin-bottom: 18px;border-width: 0px;border-style: initial;border-color: initial;font-variant-numeric: inherit;font-variant-east-asian: inherit;font-stretch: inherit;font-size: 16px;line-height: 25px;font-family: initial;vertical-align: baseline;word-break: break-all;color: rgb(0, 0, 0);text-align: start;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 32px;\">\uff08\u4e00\uff09\u516c\u53f8\u5728&nbsp;<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">2012&nbsp;<\/span>\u5e74\u4e0e\u56fd\u5bb6\u5343\u4eba\u8ba1\u5212\u7279\u8058\u4e13\u5bb6\u674e\u61ff\u535a\u58eb\u5171\u540c\u521b\u7acb\u9999\u96ea\u751f\u547d\u79d1\u5b66\u7814\u7a76\u4e2d\u5fc3\uff0c\u642d\u5efa\u4e86\u5177\u6709\u56fd\u9645\u9886\u5148\u6c34\u5e73\u524d\u6cbf\u751f\u7269\u6280\u672f\u533b\u53d1\u57fa\u5730\u548c\u8f6c\u5316\u5e73\u53f0\u3002<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">2015&nbsp;<\/span>\u5e74\u6210\u7acb\u63a7\u80a1\u5b50\u516c\u53f8\u5e7f\u4e1c\u9999\u96ea\u7cbe\u51c6\u533b\u7597\u6280\u672f\u6709\u9650\u516c\u53f8\uff08<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">XLifeSc<\/span>\uff09\uff0c\u4e3b\u8981\u5f00\u5c55\u4ee5\u5177\u6709\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684\u9ad8\u4eb2\u548c\u6027&nbsp;<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">T&nbsp;<\/span>\u7ec6\u80de\u53d7\u4f53\uff08<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">TCR<\/span>\uff09\u6838\u5fc3\u6280\u672f\u4e3a\u4e3b\u5f00\u53d1\u65b0\u4e00\u4ee3\u6297\u80bf\u7624\u65b0\u836f\u548c\u7279\u5f02\u6027&nbsp;<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">T&nbsp;<\/span>\u7ec6\u80de\u8fc7\u7ee7\u514d\u75ab\u6cbb\u7597\u4e34\u5e8a\u5e94\u7528\u6280\u672f\u3002<\/p>\n<p class=\"p12\" style=\"box-sizing: border-box;margin-top: 16px;margin-bottom: 18px;border-width: 0px;border-style: initial;border-color: initial;font-variant-numeric: inherit;font-variant-east-asian: inherit;font-stretch: inherit;font-size: 16px;line-height: 25px;font-family: initial;vertical-align: baseline;word-break: break-all;color: rgb(0, 0, 0);text-align: start;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 32px;\">\uff08\u4e8c\uff09\u9999\u96ea\u7cbe\u51c6\u5df2\u5efa\u7acb&nbsp;<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">TCR-T<\/span><span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">&nbsp;<\/span>\u5b8c\u6574\u7684\u6280\u672f\u5e73\u53f0\u53ca\u5de5\u827a\uff0c\u5305\u62ec\uff1a\u80bf\u7624\u7279\u5f02\u6027\u6297\u539f\u7684\u53d1\u73b0\u5e73\u53f0\u3001<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">TCR&nbsp;<\/span>\u7b5b\u9009\u4e0e\u4eb2\u548c\u529b\u4f18\u5316\u5e73\u53f0\u3001\u86cb\u767d\u8868\u8fbe\u5e73\u53f0\u3001\u6297\u539f\u5236\u5907\u5e73\u53f0\u3001<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">T<\/span>\u7ec6\u80de\u514b\u9686\u5e73\u53f0\u3001\u4e34\u5e8a\u7ea7\u6162\u75c5\u6bd2\u751f\u4ea7\u5de5\u827a\u3001\u4e34\u5e8a\u7ea7&nbsp;<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">TCR-T<\/span><span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">&nbsp;<\/span>\u7ec6\u80de\u751f\u4ea7\u5de5\u827a\u7b49\uff1b\u5f62\u6210\u4e86\u5177\u6709\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u5b8c\u6574\u7684&nbsp;<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">TCR-T<\/span><span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">&nbsp;<\/span>\u7ec6\u80de\u6cbb\u7597\u6280\u672f\u548c\u4ea7\u54c1\u5f00\u53d1\u3001\u751f\u4ea7\u53ca\u8d28\u63a7\u7ba1\u7ebf\uff0c\u5f00\u53d1\u9ad8\u5f3a\u7279\u5f02\u6027\u7684\u65b0\u4e00\u4ee3\u6297\u80bf\u7624&nbsp;<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">TCR-T<\/span><span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">&nbsp;<\/span>\u7ec6\u80de\u6cbb\u7597\u65b0\u836f\uff08<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">TAEST<\/span>\uff09\u3002<\/p>\n<p class=\"p9\" style=\"box-sizing: border-box;margin-top: 16px;margin-bottom: 18px;border-width: 0px;border-style: initial;border-color: initial;font-variant-numeric: inherit;font-variant-east-asian: inherit;font-stretch: inherit;font-size: 16px;line-height: 25px;font-family: initial;vertical-align: baseline;word-break: break-all;color: rgb(0, 0, 0);text-align: start;white-space: normal;background-color: rgb(255, 255, 255);text-indent: 32px;\">\uff08\u4e09\uff09<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">TAEST16001&nbsp;<\/span>\u6ce8\u5c04\u6db2\u4f5c\u4e3a\u9999\u96ea\u7cbe\u51c6\u7814\u53d1\u7ba1\u7ebf\u7684\u7b2c\u4e00\u4e2a\u4ea7\u54c1\uff0c\u4e3a&nbsp;<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">NY-ESO-1<\/span>\u6297\u539f\u7279\u5f02\u6027\u9ad8\u4eb2\u548c\u6027&nbsp;<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">T&nbsp;<\/span>\u7ec6\u80de\u53d7\u4f53\u8f6c\u5bfc\u7684\u81ea\u4f53&nbsp;<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">T&nbsp;<\/span>\u7ec6\u80de\u6ce8\u5c04\u6db2\uff0c\u662f\u7ecf\u8fc7&nbsp;<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">T&nbsp;<\/span>\u7ec6\u80de\u53d7\u4f53\uff08<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">Tcell receptor, TCR<\/span>\uff09\u57fa\u56e0\u4fee\u9970\u7684\u81ea\u4f53&nbsp;<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">T&nbsp;<\/span>\u7ec6\u80de\uff0c\u8be5&nbsp;<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">T&nbsp;<\/span>\u7ec6\u80de\u8868\u9762\u8868\u8fbe\u4e86\u7279\u5f02\u6027\u8bc6\u522b<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">HLA-A*02:01<\/span>&nbsp;<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">\u9650 \u5236 \u578b \u7684 \u7ebd \u7ea6 \u98df \u7ba1 \u9cde \u72b6 \u4e0a \u76ae \u764c \u6297 \u539f&nbsp;<\/span>1&nbsp;<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">\uff08&nbsp;<\/span>New York esophagealsquamous cell&nbsp;<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">carcinoma-1,<\/span>&nbsp;<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">NY-ESO-1<span class=\"\" style=\"font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">\uff09\u7684\u9ad8\u4eb2\u548c\u6027<\/span>&nbsp;<\/span>TCR<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">\u3002<\/span>TAEST16001&nbsp;<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">\u9488\u5bf9\u7684<\/span>\u9776\u70b9\u662f&nbsp;<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">HLA-A*02:01&nbsp;<\/span>\u53ca&nbsp;<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">NY-ESO-1&nbsp;<\/span>\u6297\u539f\u80bd\u7ec4\u6210\u7684\u590d\u5408\u7269\uff0c\u4f7f\u7528\u65e0\u81ea\u6211\u590d\u5236\u80fd\u529b\u7684\u6162\u75c5\u6bd2\u8f6c\u5bfc\u81ea\u4f53&nbsp;<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">T&nbsp;<\/span>\u7ec6\u80de\uff0c\u8868\u8fbe&nbsp;<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">NY-ESO-1&nbsp;<\/span>\u6297\u539f\u7279\u5f02\u6027\u7684&nbsp;<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">TCR<\/span>\u3002<span style=\"color: rgb(0, 122, 170);\">\u4e34\u5e8a&nbsp;<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">PI&nbsp;<\/span>\u7814\u7a76\u8868\u660e\uff0c<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">TAEST16001&nbsp;<\/span>\u6cbb\u7597\u7684\u75c5\u4eba\u5176\u56de\u8f93\u7684&nbsp;<span class=\"\" style=\"box-sizing: border-box;border-width: 0px;border-style: initial;border-color: initial;font-style: inherit;font-variant: inherit;font-stretch: inherit;line-height: 25px;font-family: inherit;vertical-align: baseline;\">T&nbsp;<\/span>\u7ec6\u80de\u5728\u4f53\u5185\u80fd\u591f\u957f\u65f6\u95f4\u7ef4\u6301\uff0c\u5e76\u4f53\u73b0\u8f83\u597d\u7684\u6cbb\u7597\u6548\u679c\uff1f<\/span><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background: rgb(255, 255, 255);line-height: 32px;box-sizing: border-box !important;word-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: \u5fae\u8f6f\u96c5\u9ed1;color: rgb(89, 89, 89);letter-spacing: 2px;font-size: 14px;box-sizing: border-box !important;word-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box !important;word-wrap: break-word !important;\">\u66f4\u591a\u4fe1\u606f\uff0c\u626b\u7801\u5173\u6ce8\u836f\u878d\u6570\u636e\uff01<\/span><\/span><\/strong><\/p>\n<p style=\"max-width: 100%;min-height: 1em;letter-spacing: 0.544px;white-space: normal;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;word-wrap: break-word !important;\"><img class=\"\"      style=\"zoom: 0.8;box-sizing: border-box !important;word-wrap: break-word !important;visibility: visible !important;width: 449px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/2-1554965804.jpg\" alt=\"\u3010\u91cc\u7a0b\u7891\u3011\u9996\u4e2aTCR- T \u7ec6\u80de\u6ce8\u5c04\u6db2\u5728\u56fd\u5185\u83b7\u51c6\u4e34\u5e8a\uff01\" title=\"\u3010\u91cc\u7a0b\u7891\u3011\u9996\u4e2aTCR- T \u7ec6\u80de\u6ce8\u5c04\u6db2\u5728\u56fd\u5185\u83b7\u51c6\u4e34\u5e8a\uff01\"  \/><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; &nbsp; &nbsp; &nbsp;\u6839\u636e\u836f\u878d\u6570\u636e\uff0cPharnex Datamonitor\uff0c2 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