{"id":82284,"date":"2019-04-01T00:00:50","date_gmt":"2019-04-11T06:59:30","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/82284\/"},"modified":"2019-04-11T14:59:32","modified_gmt":"2019-04-11T06:59:32","slug":"1c68da2251","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/82284\/","title":{"rendered":"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u7814\u7a76\u8fdb\u5c55\u6982\u89c8"},"content":{"rendered":"
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\u672c\u6587\u4f9d\u636eInforma\u6570\u636e\u5e93\u7edf\u8ba1\u8d44\u6599\uff0c\u68b3\u7406\u4e86\u8fd1\u4e00\u4e2a\u6708\uff082019\u5e742\u670815\u65e5\uff5e2019\u5e743\u670814\u65e5\uff09\u5728\u7814\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\u60c5\u51b5\uff0c\u5bf9\u4e34\u5e8a\u7814\u7a76\u6709\u79ef\u6781\u8fdb\u5c55\uff08Informa\u6570\u636e\u5e93\u8bc4\u4f30\u7814\u53d1\u6210\u529f\u7387\u5347\u9ad8\uff09\u53ca\u7ed3\u679c\u4e0d\u4f73\uff08Informa\u6570\u636e\u5e93\u8bc4\u4f30\u7814\u53d1\u6210\u529f\u7387\u964d\u4f4e\uff09\u7684\u4e8b\u4ef6\u8fdb\u884c\u7b80\u8ff0\uff0c\u4f9b\u7814\u53d1\u4eba\u5458\u53c2\u8003\u3002<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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1. \u4e34\u5e8a\u8bd5\u9a8c\u79ef\u6781\u8fdb\u5c55\u4e8b\u4ef6<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n

<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u636e\u7edf\u8ba1\uff0c\u670987\u4e2a\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u53d6\u5f97\u79ef\u6781\u8fdb\u5c55\uff08\u9644\u88681\uff09\uff0c\u5176\u4e2d\u5305\u62ec\u793c\u6765\u548c\u8f89\u745e\u7684\u6b62\u75db\u836fTanezumab\u3001Intercept\u5236\u836fOcaliva\u7528\u4e8e\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u5f15\u8d77\u7684\u809d\u7ea4\u7ef4\u5316\u60a3\u8005\u7684\u2162\u671f\u9633\u6027\u7814\u7a76\u7ed3\u679c\u3001Umbralisib\u7528\u4e8e\u6cbb\u7597\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684IIb\u671f\u4e34\u5e8a\u7814\u7a76\u3001FMX103\u6cbb\u7597\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u4e18\u75b9\u8113\u75b1\u6027\u9152\u6e23\u9f3b\u7684\u2162\u671f\u4e34\u5e8a\u5f00\u653e\u6807\u7b7e\u7814\u7a76\u79ef\u6781\u6570\u636e\u3001Lynparza\u5728\u6cbb\u7597\u643a\u5e26\u79cd\u7cfbBRCA\u57fa\u56e0\u7a81\u53d8\uff08gBRCAm\uff09\u7684\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u60a3\u8005\u7684\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8fbe\u5230\u8bd5\u9a8c\u4e3b\u8981\u7ec8\u70b9\u3001\u963f\u65af\u5229\u5eb7\u516c\u53f8\u53e3\u670dP2Y12\u53d7\u4f53\u62ee\u6297\u5242Brilinta\u5fc3\u8840\u7ba1\u9884\u540e\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u8fbe\u5230\u4e86\u4e3b\u8981\u7ec8\u70b9\u3001\u9020\u8840\u57fa\u56e0\u7597\u6cd5OTL-101\u5728\u6cbb\u7597\u817a\u82f7\u8131\u6c28\u9176\u7f3a\u4e4f\u75c7\u5bfc\u81f4\u7684\u4e25\u91cd\u8054\u5408\u514d\u75ab\u7f3a\u9677\u60a3\u8005\u7684\u6ce8\u518c\u6027\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u663e\u793a\u79ef\u6781\u7ed3\u679c\u3001Vertex\u5236\u7a76\u6027\u65b0\u836fVX-445\u4e0eIvacaftor\u548cTezacaftor\u7ed3\u5408\u7684\u4e09\u8054\u65b9\u6848\u6cbb\u7597\u56ca\u6027\u7ea4\u7ef4\u5316\u60a3\u8005\u7684\u4e24\u9879\u2162\u671f\u7814\u7a76\u5747\u7b26\u5408\u5176\u4e3b\u8981\u7ec8\u70b9\u3001Vadadustat\u5728\u6cbb\u7597\u80be\u6027\u8d2b\u8840\u60a3\u8005\u7684\u591a\u9879\u2162\u671f\u4e2d\u83b7\u5f97\u79ef\u6781\u7ed3\u679c\u3001\u521b\u65b0\u6280\u672f\u5e73\u53f0TransCon\u751f\u957f\u6fc0\u7d20\u6cbb\u7597\u513f\u7ae5\u751f\u957f\u6fc0\u7d20\u7f3a\u4e4f\u75c7\u7684\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u83b7\u5f97\u79ef\u6781\u9876\u7ebf\u6570\u636e\u3001AXO-Lenti-PD\u57fa\u56e0\u7597\u6cd5\u6cbb\u7597\u5e15\u91d1\u68ee\u75c7\u7684\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u53d6\u5f97\u79ef\u6781\u7684\u65e9\u671f\u6570\u636e\u30012\u578b\u80a2\u5e26\u578b\u808c\u8425\u517b\u4e0d\u826f\u75c7\u57fa\u56e0\u6cbb\u7597\u5019\u9009\u836f\u7269MYO-101\u57283\u540d\u60a3\u8005\u7684I\/IIa\u671f\u7814\u7a76\u4e2d\u5c55\u73b0\u4e86\u79ef\u6781\u7684\u9633\u6027\u7ed3\u679c\u3001\u672f\u540e\u957f\u6548\u6b62\u75db\u836f\u7269TLC590\u7684\u2160\/\u2161\u671f\u8bd5\u9a8c\u7ed3\u679c\u79ef\u6781\u3002\u4e0b\u6587\u9009\u53d6\u4ee5\u4e0a\u6709\u79ef\u6781\u8fdb\u5c55\u7684\u65b0\u836f\u4f5c\u7b80\u8981\u4ecb\u7ecd\u3002<\/span>
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1.1 Tanezumab<\/span><\/strong><\/p>\n

Tanezumab\u662f\u4e00\u6b3e\u5728\u7814\u7684\u4eba\u6e90\u5316\u795e\u7ecf\u751f\u957f\u56e0\u5b50\uff08NGF\uff09\u5355\u514b\u9686\u6297\u4f53\uff0c\u4e5f\u662f\u9996\u4e2a\u5f97\u5230FDA\u5feb\u901f\u901a\u9053\u8d44\u683c\u7684NGF\u6291\u5236\u5242\uff0c\u5b83\u5177\u6709\u53ef\u4ee5\u9009\u62e9\u6027\u7ed3\u5408\u5e76\u6291\u5236NGF\u7684\u529f\u80fd\u3002\u5728\u4eba\u4f53\u51fa\u73b0\u56e0\u53d7\u4f24\u3001\u708e\u75c7\u5f15\u8d77\u7684\u75bc\u75db\u6216\u6162\u6027\u75bc\u75db\u65f6\uff0cNGF\u7684\u6c34\u5e73\u4e5f\u4f1a\u76f8\u5e94\u4e0a\u5347\u3002\u56e0\u6b64\uff0c\u901a\u8fc7\u9009\u62e9\u6027\u6291\u5236NGF\uff0cTanezumab\u53ef\u80fd\u6709\u52a9\u4e8e\u963b\u65ad\u808c\u8089\u3001\u76ae\u80a4\u548c\u5668\u5b98\u4ea7\u751f\u7684\u75bc\u75db\u4fe1\u53f7\u8fdb\u5165\u810a\u9ad3\u548c\u5927\u8111\u3002\u8fd1\u65e5\uff0cTanezumab\u5728\u6cbb\u7597\u9aa8\u6027\u5173\u8282\u708e\u7684\u2162\u671f\u8bd5\u9a8c\u4e2d\uff0c\u53d6\u5f97\u79ef\u6781\u7ed3\u679c\uff0c\u5176\u4e2d\u4f4e\u5242\u91cf\u7684\u6cbb\u7597\u8fbe\u5230\u4e86\u4e09\u4e2a\u4e3b\u8981\u7ec8\u70b9\u4e2d\u7684\u4e24\u4e2a\uff0c\u800c\u9ad8\u5242\u91cf\u7684\u6cbb\u7597\u5219\u8fbe\u5230\u4e86\u5168\u90e8\u4e09\u4e2a\u4e3b\u8981\u7ec8\u70b9\u3002<\/span><\/p>\n

Tanezumab\u7684\u4e34\u5e8a\u7814\u7a76\u76ee\u524d\u4e3b\u8981\u9488\u5bf9\u9aa8\u5173\u8282\u708e\u75bc\u75db\u3001\u91cd\u5ea6\u6162\u6027\u8170\u75bc\u4ee5\u53ca\u7531\u4e8e\u764c\u75c7\u9aa8\u8f6c\u79fb\u5f15\u8d77\u7684\u75bc\u75db\u8fd93\u7c7b\u75bc\u75db\u7684\u6cbb\u7597\u3002\u8f89\u745e\u548c\u793c\u6765\u81ea2013\u5e74\u4ee5\u6765\u5171\u540c\u5f00\u53d1\u6b64\u836f\u7269\uff0c\u5206\u522b\u5f00\u5c55\u4e86\u9488\u5bf9\u4e0a\u8ff03\u79cd\u75bc\u75db\u76846\u98793\u671f\u8bd5\u9a8c\uff0c\u8986\u76d6\u4e867000\u540d\u60a3\u8005\u3002\u672c\u6b21\u62a5\u9053\u7684\u4e3a\u671f24\u5468\u76843\u671f\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30\u5728\u6cbb\u7597\u819d\u5173\u8282\u6216\u9acb\u5173\u8282\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u9aa8\u5173\u8282\u708e\u75bc\u75db\u60a3\u8005\u4e2d\uff0cTanezumab\u9547\u75db\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u5b9e\u9a8c\u5bf9\u8c61\u4e4b\u524d\u81f3\u5c11\u5bf93\u79cd\u4e0d\u540c\u7c7b\u578b\u7684\u6b62\u75db\u836f\u8868\u73b0\u7f13\u89e3\u4e0d\u8db3\u6216\u4e0d\u8010\u53d7\uff0c\u540c\u65f6\u5e73\u5747\u60a3\u6709\u9aa8\u5173\u8282\u708e\u8d85\u8fc76\u5e74\u3002\u8be5\u8bd5\u9a8c\u662f\u5728\u6b27\u6d32\u548c\u65e5\u672c\u8fdb\u884c\u7684\u30022.5 mg\u5242\u91cf\u7ec4\u7684\u60a3\u8005\u8fbe\u5230\u4e86\u8bd5\u9a8c\u65b9\u6848\u5236\u5b9a\u76843\u4e2a\u5171\u540c\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u4e2d\u7684\u4e24\u4e2a\uff1a\u5373\u8868\u73b0\u51fa\u75bc\u75db\u548c\u8eab\u4f53\u529f\u80fd\u7684\u7edf\u8ba1\u5b66\u663e\u8457\u6539\u5584\u3002\u7136\u800c\uff0c\u60a3\u8005\u5bf9\u9aa8\u5173\u8282\u708e\u7684\u603b\u4f53\u8bc4\u4ef7\u4e0e\u5b89\u6170\u5242\u7ec4\u5e76\u65e0\u7edf\u8ba1\u5b66\u5dee\u5f02\u30025mg\u5242\u91cf\u7ec4\u7684\u60a3\u8005\u5728\u7b2c24\u5468\u65f6\u8fbe\u5230\u4e86\u6240\u6709\u4e0a\u8ff03\u4e2a\u5171\u540c\u4e3b\u8981\u7597\u6548\u7ec8\u70b9\u3002<\/span><\/p>\n

1.2 Ocaliva<\/span><\/strong><\/p>\n

Intercept\u5236\u836f\u516c\u53f8\u8fd1\u65e5\u5ba3\u5e03\uff0cOcaliva\uff08obeticholic acid\uff09\u7528\u4e8e\u6cbb\u7597\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u5f15\u8d77\u7684\u809d\u7ea4\u7ef4\u5316\u60a3\u8005\u7684III\u671f\u8bd5\u9a8c\u7b26\u5408\u7ea4\u7ef4\u5316\u6539\u5584\u7684\u4e3b\u8981\u7ec8\u70b9\u3002\u8be5\u516c\u53f8\u8fd8\u53d1\u62a5\u544a\u6307\u51fa\uff0cOcaliva\u6ca1\u6709\u5bfc\u81f4\u5176\u4ed6\u4e3b\u8981\u7ec8\u70b9\u7684\u663e\u8457\u5dee\u5f02\uff0c\u4f46\u662f\u4ec5\u4ec5\u6ee1\u8db3\u4e86\u7ea4\u7ef4\u5316\u6539\u5584\u7684\u4e3b\u8981\u7ec8\u70b9\u4fbf\u8db3\u4ee5\u88abFDA\u8ba4\u53ef\u3002<\/span><\/p>\n

\u8be5\u9879\u2162\u671f\u8bd5\u9a8c\u5206\u6790\u8bc4\u4f30\u4e86931\u4f8b\u7531NASH\u5f15\u8d77\u76842\u62163\u671f\u809d\u7ea4\u7ef4\u5316\u60a3\u8005\u5728\u4f7f\u7528Ocaliva\u6cbb\u759718\u4e2a\u6708\u65f6\u7684\u6709\u6548\u6027\uff0c\u8fd9\u4e9b\u60a3\u8005\u88ab\u968f\u673a\u5206\u914d\u5230\u6bcf\u65e5\u4e00\u6b21\u7684Ocaliva\u7ec4\uff08\u5242\u91cf\u4e3a10mg\u621625mg\uff09\u6216\u5b89\u6170\u5242\u7ec4\uff0c\u5176\u4e2d\u4e00\u4e2a\u4e3b\u8981\u7ec8\u70b9\u662f\u7ea4\u7ef4\u5316\u6539\u5584\u3002\u7ed3\u679c\u663e\u793a\uff0c\u4f4e\u5242\u91cf\u548c\u9ad8\u5242\u91cfOcaliva\u7ec4\u60a3\u8005\u4e2d\u5206\u522b\u670917.6%\u548c23.1%\u7684\u60a3\u8005\u51fa\u73b0\u7ea4\u7ef4\u5316\u7684\u6539\u5584\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u4ec5\u4ec5\u4e3a11.9%\u3002\u7ed3\u679c\u8868\u660e\uff0c25mg\u9ad8\u5242\u91cf\u7ec4\u4e2d\u5b9e\u73b0\u4e86\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u3002\u540c\u65f6\uff0c\u4f4e\u5242\u91cf\u548c\u9ad8\u5242\u91cfOcaliva\u7ec4\u7684NASH\u5206\u8fa8\u7387\u5206\u522b\u4e3a11.2%\u548c11.7%\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u4e3a8%\u3002Intercept\u516c\u53f8\u8868\u793a\u5c06\u57282019\u5e74\u4e0b\u534a\u5e74\u5411\u7f8e\u56fd\u548c\u6b27\u6d32\u63d0\u4ea4Ocaliva\u7684\u76d1\u7ba1\u6279\u51c6\u3002<\/span><\/p>\n

1.3 Umbralisib<\/span><\/strong><\/p>\n

Umbralisib\u662f\u4e00\u79cd\u53e3\u670d\u65b0\u4e00\u4ee3\u7684PI3K\u03b4\u6291\u5236\u5242\uff0c\u53ef\u72ec\u7279\u5730\u6291\u5236CK1-\u03b5\uff0c\u6b64\u524d\uff0cUmbralisib\u88abFDA\u6388\u4e88\u65e2\u5f80\u5df2\u63a5\u53d7\u81f3\u5c11\u4e00\u79cd\u6297CD20\u65b9\u6848\u7684\u8fb9\u7f18\u533a\u6dcb\u5df4\u7624\uff08MZL\uff09\u6210\u4eba\u60a3\u8005\u7684\u7a81\u7834\u6027\u836f\u7269\u8d44\u683c\u3002\u8fd1\u65e5\uff0cTG Therapeutics\u5ba3\u5e03\u8bc4\u4f30Umbralisib\uff08TGR-1202\uff09\u6cbb\u7597\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624IIb\u671f\u4e34\u5e8a\u7814\u7a76UNITY-NHL\u7684MZL\u961f\u5217\u8fbe\u5230\u4e86\u7531\u72ec\u7acb\u5ba1\u67e5\u59d4\u5458\u4f1a\u786e\u5b9a\u7684\u6240\u6709\u6cbb\u7597\u60a3\u8005\uff0869\u4eba\uff09\u603b\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3b\u8981\u7ec8\u70b9\uff0c\u8be5\u7ed3\u679c\u8fbe\u5230\u4e86\u8be5\u516c\u53f8ORR\u4e3a40~50%\u7684\u76ee\u6807\u6307\u5bfc\u503c\u3002<\/span><\/p>\n

\u76ee\u524d\uff0c\u8fd8\u6ca1\u6709\u83b7\u5f97\u76d1\u7ba1\u673a\u6784\u5b8c\u5168\u6279\u51c6\u6cbb\u7597MZL\u7684\u836f\u7269\uff0c\u56e0\u6b64\u8be5\u9886\u57df\u5b58\u5728\u7740\u663e\u8457\u672a\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\u3002\u9664\u4e86Umbralisib\u4e4b\u5916\uff0cTG Therapeutics\u516c\u53f8\u8fd8\u6709\u4e00\u6b3e\u5355\u6297\u836f\u7269Ublituximab\u8fdb\u5165\u2162\u671f\u4e34\u5e8a\u5f00\u53d1\uff0c\u4ee5Ublituximab\u3001Umbralisib\u4ee5\u53ca2\u8005\u7684\u7ec4\u5408\uff08U2\uff09\u6cbb\u7597\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u5747\u5904\u4e8eIII\u671f\u4e34\u5e8a\u3002<\/span><\/p>\n

1.4 FMX103<\/span><\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u4ee5\u8272\u5217Foamix\u5236\u836f\u516c\u53f8\u516c\u5e03\u4e86FMX103\uff081.5%\u7c73\u8bfa\u73af\u7d20\u6ce1\u6cab\uff09\u2162\u671f\u5f00\u653e\u6807\u7b7e\u7814\u7a76\uff08FX2016-13\uff09\u7684\u79ef\u6781\u6570\u636e\uff0c\u8be5\u7814\u7a76\u8bc4\u4f30\u4e86FMX103\u6cbb\u7597\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u4e18\u75b9\u8113\u75b1\u6027\u9152\u6e23\u9f3b\uff08PPR\uff09\u957f\u8fbe\u4e00\u5e74\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u672c\u6b21\u7814\u7a76\u5171410\u4f8b\u60a3\u8005\u5b8c\u6210\u7814\u7a76\uff0c\u5176\u5b89\u5168\u6027\u6027\u7ed3\u679c\u4e3a\uff1a\u975e\u76ae\u80a4\u6027\u4e0d\u826f\u4e8b\u4ef6\u7684\u7c7b\u578b\u548c\u9891\u7387\u4e0e\u5148\u524d\u7684\u53cc\u76f2\u62a5\u544a\u76f8\u4f3c\u3002\u6700\u5e38\u89c1\u7684\u6cbb\u7597\u4e2d\u51fa\u73b0\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TEAE\uff09\u4e3a\u4e0a\u547c\u5438\u9053\u611f\u67d3\uff0c\u5982\u666e\u901a\u611f\u5192\uff083.8%\uff09\u30024\u4f8b\u60a3\u8005\u56e0\u975e\u5e94\u7528\u90e8\u4f4d\u4e0d\u826f\u53cd\u5e94\uff08\u77b3\u5b54\u7f29\u5c0f\u3001\u8d2b\u8840\/\u767d\u7ec6\u80de\u589e\u591a\u3001\u9611\u5c3e\u708e\u548c\u5185\u751f\u8f6f\u9aa8\u7624\uff09\u800c\u505c\u6b62\u7814\u7a76\u3002\u672a\u62a5\u544a\u4e25\u91cd\u7684\u836f\u7269\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u3002\u5728\u4f7f\u7528FMX103\u989d\u591640\u5468\u5f00\u653e\u6807\u7b7e\u6cbb\u7597\u671f\u95f4\uff0c\u76ae\u80a4\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u5728\u22641%\u7684\u60a3\u8005\u4e2d\u3002\u5728\u7b2c52\u5468\u5bf9\u9762\u90e8\u76ae\u80a4\u8010\u53d7\u6027\u7684\u8bc4\u4f30\u4e2d\uff0c95%\u4ee5\u4e0a\u7684\u60a3\u8005\u8981\u4e48\u6ca1\u6709\u4f53\u5f81\u6216\u75c7\u72b6\uff0c\u8981\u4e48\u4f53\u5f81\/\u75c7\u72b6\u88ab\u5f52\u7c7b\u4e3a\u201c\u8f7b\u5ea6\u201d\uff08\u707c\u4f24\/\u523a\u75db\u3001\u8138\u7ea2\/\u8138\u7ea2\u3001\u5e72\u71e5\u3001\u7619\u75d2\u3001\u8131\u76ae\u548c\u8272\u7d20\u6c89\u7740\u8fc7\u591a\uff09\u3002\u4e0e\u5148\u524d\u53cc\u76f2\u7814\u7a76\u7684\u57fa\u7ebf\u76f8\u6bd4\uff0c\u9152\u6e23\u9f3b\u7684\u4e3b\u8981\u4e34\u5e8a\u8868\u73b0\uff08\u7ea2\u6591\u548c\u6bdb\u7ec6\u8840\u7ba1\u6269\u5f20\uff09\u7684\u4e25\u91cd\u6027\u5747\u663e\u8457\u6539\u5584\u3002\u5176\u4e3b\u8981\u7597\u6548\u7ed3\u679c\u4e3a\uff1a\u4e0e\u5148\u524d\u53cc\u76f2\u7814\u7a76\u57fa\u7ebf\u76f8\u6bd4\uff082\u7ec4\u53d7\u8bd5\u8005\u5bf9\u5e94\u7684\u57fa\u7ebf\u5e73\u5747\u708e\u75c7\u635f\u4f24\u8ba1\u6570\u5206\u522b\u4e3a28.8\u548c28.7\uff09\uff0c\u4f7f\u7528FMX103\u6cbb\u759752\u5468\u7684\u53d7\u8bd5\u8005\u708e\u75c7\u635f\u4f24\u8ba1\u6570\u7684\u5e73\u5747\u7edd\u5bf9\u51cf\u5c11-23.0\uff0c\u4f7f\u7528FMX103\u6cbb\u759740\u5468\u7684\u53d7\u8bd5\u8005\u4e3a-22.5\u3002\u7b2c52\u5468\u91c7\u7528\u7814\u7a76\u8005\u603b\u4f53\u8bc4\u4f30\uff08IGA\uff09\u8bc4\u4f30\u7684\u6cbb\u7597\u6210\u529f\u7387\uff08IGA\u8bc4\u52060\u62161\uff09\u65b9\u9762\uff0c\u4f7f\u7528FMX103\u6cbb\u759752\u5468\u7684\u53d7\u8bd5\u8005\u4e2d\u4e3a81.6%\u3001\u4f7f\u7528FMX103\u6cbb\u759740\u5468\u7684\u53d7\u8bd5\u8005\u4e2d\u4e3a76.0%\u3002<\/span><\/p>\n

\u8be5\u9879\u7efc\u5408\u5b89\u5168\u6027\u8bc4\u4f30\u9a8c\u8bc1\u4e86\u5148\u524d\u7814\u7a76\u6570\u636e\uff0c\u8868\u660eFMX103\u5728\u6cbb\u7597PPR\u65f6\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u603b\u4f53\u5b89\u5168\u6027\u826f\u597d\uff0c\u60a3\u8005\u6ee1\u610f\u5ea6\u9ad8\u3002\u8fd9\u4e9b\u6570\u636e\u4ee3\u8868\u4e86\u6700\u7ec8\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u96c6\uff0c\u7eb3\u5165FMX103\u7684\u65b0\u836f\u7533\u8bf7\uff08NDA\uff09\u63d0\u4ea4\u6587\u4ef6\u3002FMX103\u662fFoamix\u516c\u53f8\u91c7\u7528\u4e13\u6709\u7684\u6ce1\u6cab\u6280\u672f\u5f00\u53d1\u7684\u4e00\u6b3e\u5c40\u90e8\u5916\u7528\u7c73\u8bfa\u73af\u7d20\u6ce1\u6cab\u5236\u5242\uff0c\u5728\u4e34\u5e8a\u7814\u7a76\u4e2d\u53ef\u663e\u8457\u51cf\u5c11\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u4e18\u75b9\u8113\u75b1\u6027\u9152\u6e23\u9f3b\u60a3\u8005\u7684\u708e\u6027\u75c5\u53d8\u3002\u5982\u679c\u83b7\u6279\uff0c\u5c06\u6210\u4e3a\u9996\u4e2a\u53ef\u7528\u4e8e\u6cbb\u7597\u9152\u6e23\u9f3b\u7684\u5c40\u90e8\u5916\u7528\u7c73\u8bfa\u73af\u7d20\u4ea7\u54c1\u3002<\/span><\/p>\n

1.5 Lynparza<\/span><\/strong><\/p>\n

Lynparza\uff08\u4e2d\u6587\u540d\uff1a\u5229\u666e\u5353\uff09\u662f\u963f\u65af\u5229\u5eb7\u548c\u9ed8\u6c99\u4e1c\u8054\u5408\u5f00\u53d1\u7684\u6297\u80bf\u7624\u836f\u7269\u3002\u8fd1\u671f\uff0cLynparza\u4f5c\u4e3a\u4e00\u7ebf\u7ef4\u6301\u7597\u6cd5\uff0c\u5728\u6cbb\u7597\u643a\u5e26\u79cd\u7cfbBRCA\u57fa\u56e0\u7a81\u53d8\uff08gBRCAm\uff09\u7684\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u60a3\u8005\u7684\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u8fbe\u5230\u8bd5\u9a8c\u4e3b\u8981\u7ec8\u70b9\u3002\u8fd9\u662f\u7b2c\u4e00\u6b3e\u5728\u2162\u671f\u8bd5\u9a8c\u4e2d\u8bc1\u660e\u8ba9gBRCAm\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u60a3\u8005\u83b7\u76ca\u7684PARP\u6291\u5236\u5242\u3002Lynparza\u662f\u9996\u4e2a\u83b7\u6279\u7684PARP\u6291\u5236\u5242\uff0c\u4e5f\u662f\u7b2c\u4e00\u4e2a\u9488\u5bf9DNA\u635f\u4f24\u4fee\u590d\uff08DDR\uff09\u9014\u5f84\u7f3a\u9677\uff08\u5982BRCA\u57fa\u56e0\u7a81\u53d8\uff09\u7684\u9776\u5411\u7597\u6cd5\u3002<\/span><\/p>\n

\u53c2\u4e0e\u672c\u6b21\u2162\u671f\u8bd5\u9a8c\u7684154\u540d\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u60a3\u8005\u90fd\u643a\u5e26gBRCAm\uff0c\u5e76\u5728\u6b64\u524d\u8fdb\u884c\u7684\u4e00\u7ebf\u94c2\u57fa\u5316\u7597\u671f\u95f4\u6ca1\u6709\u53d1\u751f\u75be\u75c5\u8fdb\u5c55\u3002\u8fd9\u4e9b\u8bd5\u9a8c\u5bf9\u8c61\u63093:2\u6bd4\u4f8b\u88ab\u968f\u673a\u5206\u914d\uff0c\u5206\u522b\u63a5\u53d7\u6bcf\u65e5\u4e24\u6b21300 mg\u7684Lynparza\u6216\u5b89\u6170\u5242\uff0c\u4f5c\u4e3a\u4e00\u7ebf\u7ef4\u6301\u7597\u6cd5\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u3002\u8bd5\u9a8c\u7684\u4e3b\u8981\u7ec8\u70b9\u662f\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\uff0c\u5173\u952e\u7684\u6b21\u8981\u7ec8\u70b9\u5305\u62ec\u603b\u751f\u5b58\u671f\uff08OR\uff09\u3001\u603b\u4f53\u7f13\u89e3\u7387\uff08ORR\uff09\u3001\u75be\u75c5\u63a7\u5236\u7387\u3001\u4ee5\u53ca\u4e0e\u5065\u5eb7\u76f8\u5173\u7684\u751f\u6d3b\u8d28\u91cf\u3002\u5b9e\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u60a3\u8005\u7684PFS\u5f97\u5230\u4e86\u7edf\u8ba1\u5b66\u610f\u4e49\u4e0a\u663e\u8457\u7684\u4e34\u5e8a\u6539\u5584\u3002\u5177\u4f53\u7684\u8bd5\u9a8c\u7ed3\u679c\u5c06\u5728\u672a\u6765\u53ec\u5f00\u7684\u533b\u5b66\u5927\u4f1a\u4e0a\u516c\u5e03\u3002<\/span><\/p>\n

1.6 Brilinta<\/span><\/strong><\/p>\n

Brilinta\uff08\u4e2d\u6587\u540d\uff1a\u66ff\u5361\u683c\u96f7\uff09\u662f\u4e00\u79cd\u53e3\u670d\u3001\u53ef\u9006\u3001\u76f4\u63a5\u4f5c\u7528\u7684P2Y12\u53d7\u4f53\u62ee\u6297\u5242\uff0c\u901a\u8fc7\u6291\u5236\u8840\u5c0f\u677f\u6d3b\u5316\u53d1\u6325\u4f5c\u7528\uff0c\u7531\u963f\u65af\u5229\u5eb7\u516c\u53f8\u5f00\u53d1\u3002\u8fd1\u671f\uff0c\u8bc4\u4f30\u6297\u51dd\u8840\u5242Brilinta\u5fc3\u8840\u7ba1\u9884\u540e\u7684\u2162\u671f\u4e34\u5e8a\u7814\u7a76THEMIS\u8fbe\u5230\u4e86\u4e3b\u8981\u7ec8\u70b9\u3002\u8be5\u7814\u7a76\u4e8e2014\u5e74\u521d\u542f\u52a8\uff0c\u572819000\u591a\u4f8b\u65e2\u5f80\u65e0\u5fc3\u810f\u75c5\u53d1\u4f5c\uff08\u5fc3\u808c\u6897\u6b7b\uff0cMI\uff09\u6216\u4e2d\u98ce\u3001\u5b58\u5728\u51a0\u5fc3\u75c5\uff08CAD\uff09\u548c2\u578b\u7cd6\u5c3f\u75c5\uff08T2D\uff09\u7684\u60a3\u8005\u4e2d\u5f00\u5c55\u3002\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u5355\u72ec\u670d\u7528\u963f\u53f8\u5339\u6797\u76f8\u6bd4\uff0cBrilinta\u8054\u5408\u963f\u53f8\u5339\u6797\u4f7f\u4e3b\u8981\u4e0d\u826f\u5fc3\u8840\u7ba1\u4e8b\u4ef6\uff08MACE\uff09\u590d\u5408\u98ce\u9669\u5b9e\u73b0\u7edf\u8ba1\u5b66\u610f\u4e49\u7684\u663e\u8457\u964d\u4f4e\u3002\u8be5\u7814\u7a76\u4e2d\uff0c\u521d\u6b65\u7684\u5b89\u5168\u6027\u7ed3\u679c\u4e0eBrilinta\u5df2\u77e5\u7684\u5b89\u5168\u6982\u51b5\u4e00\u81f4\u3002<\/span><\/p>\n

\u5bf9\u4e8e\u53ef\u5e2e\u52a9\u540c\u65f6\u7f79\u60a3CAD\u548cT2D\u7684\u60a3\u8005\u8fdb\u4e00\u6b65\u964d\u4f4e\u5fc3\u8840\u7ba1\u75be\u75c5\u53d1\u75c5\u7387\u7684\u6cbb\u7597\u65b9\u6848\u5b58\u5728\u7740\u8feb\u5207\u7684\u533b\u7597\u9700\u6c42\u3002THEMIS\u7814\u7a76\u7684\u79ef\u6781\u7ed3\u679c\u53ef\u80fd\u4e3a\u8fd9\u4e00\u9ad8\u5371\u60a3\u8005\u7fa4\u4f53\u63d0\u4f9b\u6f5c\u5728\u7684\u6cbb\u7597\u76ca\u5904\u3002\u636e\u963f\u65af\u5229\u5eb72018\u5e74\u4e1a\u7ee9\u62a5\u544a\u663e\u793a\uff0cBrilinta\u7684\u9500\u552e\u989d\u4e3a13.21\u4ebf\u7f8e\u5143\uff0c\u8f832017\u5e74\u589e\u957f22%\uff0c\u8be5\u836f\u662f\u963f\u65af\u5229\u5eb7\u6700\u7545\u9500\u768410\u5927\u836f\u7269\u4e4b\u4e00\u3002\u6b64\u6b21\u5fc3\u8840\u7ba1\u7ed3\u5c40\u7814\u7a76THEMIS\u83b7\u5f97\u6210\u529f\uff0c\u6709\u671b\u8fdb\u4e00\u6b65\u62c9\u5347Brilinta\u7684\u5546\u4e1a\u6f5c\u529b\u3002<\/span><\/p>\n

1.7 OTL-101<\/span><\/strong><\/p>\n

\u8fd1\u65e5\uff0cOrchard\u516c\u53f8\u516c\u5e03\u4e86\u9020\u8840\u57fa\u56e0\u7597\u6cd5OTL-101\u5728\u6cbb\u7597\u817a\u82f7\u8131\u6c28\u9176\u7f3a\u4e4f\u75c7\u5bfc\u81f4\u7684\u4e25\u91cd\u8054\u5408\u514d\u75ab\u7f3a\u9677\u60a3\u8005\uff08ADA-SCID\uff09\u7684\u6ce8\u518c\u6027\u4e34\u5e8a\u8bd5\u9a8c\u7684\u79ef\u6781\u7ed3\u679c\u3002\u8bd5\u9a8c\u6570\u636e\u8868\u660e\uff0c\u63a5\u53d7OTL-101\u6cbb\u7597\u7684\u60a3\u8005\u5728\u4e24\u5e74\u4e4b\u540e\u7ef4\u6301100%\u7684\u603b\u751f\u5b58\u7387\u548c100%\u7684\u65e0\u4e8b\u4ef6\u751f\u5b58\u7387\u3002OTL-101\u662f\u4e00\u79cd\u81ea\u4f53\u3001\u9020\u8840\u57fa\u56e0\u7597\u6cd5\u3002\u5b83\u4ece\u60a3\u8005\u8eab\u4f53\u4e2d\u5206\u79bb\u9020\u8840\uff0c\u5728\u4f53\u5916\u901a\u8fc7\u6162\u75c5\u6bd2\u8f7d\u4f53\u5f15\u5165\u8868\u8fbe\u817a\u82f7\u8131\u6c28\u9176\u7684ADA\u57fa\u56e0\uff0c\u7136\u540e\u5c06\u6539\u9020\u8fc7\u7684\u9020\u8840\u6ce8\u56de\u60a3\u8005\u4f53\u5185\u3002\u8fd9\u4e9b\u6539\u9020\u8fc7\u7684\u9020\u8840\u80fd\u591f\u5728\u60a3\u8005\u4f53\u5185\u589e\u6b96\u5e76\u4e14\u5206\u5316\u4e3a\u5404\u79cd\u6b63\u5e38\u8868\u8fbe\u817a\u82f7\u8131\u6c28\u9176\u7684\u8840\u7ec6\u80de\u3002<\/span><\/p>\n

\u5728\u672c\u6b21\u516c\u5e03\u7ed3\u679c\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u603b\u8ba120\u540d\u5e74\u9f84\u57284\u4e2a\u6708\u52304.3\u5c81\u4e4b\u95f4\u7684ADA-SCID\u60a3\u8005\u63a5\u53d7\u4e86OTL-101\u7684\u6cbb\u7597\u3002\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u63a5\u53d7OTL-101\u7684ADA-SCID\u60a3\u8005\u5728\u63a5\u53d7\u6cbb\u759724\u4e2a\u6708\u4e4b\u540e\uff0c\u4ecd\u7136\u7ef4\u6301\u7740100%\u7684\u751f\u5b58\u7387\u548c100%\u7684\u65e0\u4e8b\u4ef6\u751f\u5b58\u7387\u3002\u5176\u4e2d\uff0c\u65e0\u4e8b\u4ef6\u751f\u5b58\u6307\u60a3\u8005\u65e0\u9700\u63a5\u53d7\u9176\u66ff\u4ee3\u7597\u6cd5\u6216\u8005\u7d27\u6025\u79fb\u690d\u624b\u672f\u6765\u63a7\u5236\u4ed6\u4eec\u7684\u75c5\u60c5\u3002\u5386\u53f2\u4e0a\u63a5\u53d7\u9020\u8840\u79fb\u690d\u7597\u6cd5\u7684\u60a3\u8005\u540c\u671f\u603b\u751f\u5b58\u7387\u4e3a88%\uff0c\u65e0\u4e8b\u4ef6\u751f\u5b58\u7387\u53ea\u670956%\u3002<\/span><\/p>\n

1.8 VX-445+ivacaftor+tezacaftor<\/span><\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u7531Vertex\u5236\u836f\u5f00\u53d1\u7684\u7814\u7a76\u6027\u65b0\u836fVX-445\u4e0eivacaftor\u548ctezacaftor\u7ed3\u5408\u7684\u4e09\u8054\u65b9\u6848\u6cbb\u7597\u56ca\u6027\u7ea4\u7ef4\u5316\uff08CF\uff09\u60a3\u8005\u7684\u4e24\u9879\u2162\u671f\u7814\u7a76\u5747\u7b26\u5408\u5176\u4e3b\u8981\u7ec8\u70b9\u3002\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u4e09\u8054\u7597\u6cd5\u4e0e\u80ba\u529f\u80fd\u7684\u6539\u5584\u663e\u8457\u76f8\u5173\u3002\u5728\u4e00\u9879\u7814\u7a76\u4e2d\uff0c\u5c06405\u540d\u5e74\u9f84\u572812\u5c81\u53ca\u4ee5\u4e0a\u4e14\u5177\u6709\u4e00\u4e2aF508del\u7a81\u53d8\u548c\u4e00\u4e2a\u6700\u5c0f\u529f\u80fd\u7a81\u53d8\u7684\u60a3\u8005\u968f\u673a\u5206\u914d\u81f3VX-445\u3001ivacaftor\u548ctezacaftor\u4e09\u8054\u7597\u6cd5\u6216\u5b89\u6170\u5242\u7ec4\u4e2d\uff0c\u6cbb\u759724\u5468\u3002\u5728\u7b2c4\u5468\u65f6\uff0c\u4e0e\u57fa\u7ebf\u76f8\u6bd4\uff0c\u4e09\u8054\u7ec4\u4e2d1\u79d2\u5185\u7528\u529b\u547c\u6c14\u91cf\uff08ppFEV1\uff09\u7684\u5e73\u5747\u53d8\u5316\u767e\u5206\u6bd4\uff08ppFEV1\uff09\u4e3a13.8\u4e2a\u767e\u5206\u70b9\u3002\u636eVertex\u79f0\uff0c\u4e09\u8054\u7597\u6cd5\u7684\u5b89\u5168\u6027\u4e0e\u5148\u524d\u7684\u7814\u7a76\u7ed3\u679c\u4e00\u81f4\uff0c\u672c\u6b21\u7814\u7a76\u7684\u4e3b\u8981\u76ee\u6807\u662f\u7ee7\u7eed\u8bc4\u4f30\u4e00\u4e9b\u6b21\u8981\u7ec8\u70b9\uff0c\u5305\u62ec\u80ba\u90e8\u6076\u5316\u7684\u6b21\u6570\u548c\u6c57\u6db2\u6c2f\u5316\u7269\u7684\u53d8\u5316\u3002<\/span><\/p>\n

1.9 Vadadustat<\/span><\/strong><\/p>\n

Vadadustat\u662f\u4e00\u6b3e\u53e3\u670d\u4f4e\u6c27\u8bf1\u5bfc\u56e0\u5b50\u812f\u6c28\u9170\u7f9f\u5316\u9176\u6291\u5236\u5242\uff0c\u7531Akebia Therapeutics\u4e0e\u7530\u8fb9\u4e09\u83f1\u682a\u5f0f\u4f1a\u793e\u8054\u5408\u5f00\u53d1\uff0c\u8fd1\u671f\uff0cVadadustat\u5728\u6cbb\u7597\u80be\u6027\u8d2b\u8840\u60a3\u8005\u7684\u591a\u9879\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u83b7\u5f97\u79ef\u6781\u7ed3\u679c\u3002\u8fd9\u9879\u540d\u4e3aJ01\u7684\u968f\u673a\u3001\u5f00\u653e\u6807\u7b7e\u3001\u6d3b\u6027\u5bf9\u7167\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c304\u540d\u975e\u900f\u6790\u4f9d\u8d56\u6027\u80be\u6027\u8d2b\u8840\u60a3\u8005\u63a5\u53d7\u4e86Vadadustat\u548c\u4e00\u6b3e\u7ea2\u7ec6\u80de\u751f\u6210\u523a\u6fc0\u5242\uff08ESA\uff09\u7684\u6cbb\u7597\u3002\u8bd5\u9a8c\u7ed3\u679c\u8868\u660e\uff0c\u63a5\u53d7\u6cbb\u759724\u5468\u540e\uff0c\u7814\u7a76\u8fbe\u5230\u5176\u4e3b\u8981\u7ec8\u70b9\u3002Vadadustat\u60a3\u8005\u7ec4\u7684\u8840\u7ea2\u86cb\u767d\u6c34\u5e73\u4e0e\u6d3b\u6027\u5bf9\u7167\u7ec4\u76f8\u6bd4\u8fbe\u5230\u975e\u52a3\u6548\u6027\u6807\u51c6\u3002\u5728\u6cbb\u7597\u900f\u6790\u4f9d\u8d56\u6027\u80be\u6027\u8d2b\u8840\u60a3\u8005\u7684J03\u968f\u673a\u53cc\u76f2\u3001\u6d3b\u6027\u5bf9\u7167\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0cVadadustat\u4e5f\u8fbe\u5230\u4e86\u8bd5\u9a8c\u7684\u4e3b\u8981\u7ec8\u70b9\uff0c\u4e0eESA\u76f8\u6bd4\u8fbe\u5230\u975e\u52a3\u6548\u6027\u6807\u51c6\u3002\u5982\u679c\u83b7\u5f97\u6279\u51c6\uff0cVadadustat\u5c06\u63d0\u4f9b\u7ed9\u60a3\u8005\u4e00\u79cd\u53e3\u670d\u6cbb\u7597\u9009\u62e9\uff0c\u5e76\u4e14\u53ef\u80fd\u6210\u4e3a\u6cbb\u7597\u80be\u6027\u8d2b\u8840\u60a3\u8005\u7684\u65b0\u6807\u51c6\u7597\u6cd5\u3002<\/span><\/p>\n

1.10 TransCon hGH<\/span><\/strong><\/p>\n

TransCon\u610f\u6307\u201c\u77ac\u65f6\u7ed3\u5408\u201d\uff0cAscendis\u516c\u53f8\u4e13\u6709\u7684TransCon\u5e73\u53f0\u662f\u4e00\u9879\u521b\u65b0\u6280\u672f\uff0c\u65e8\u5728\u521b\u9020\u4f18\u5316\u6cbb\u7597\u6548\u679c\u7684\u65b0\u7597\u6cd5\uff0c\u5305\u62ec\u7597\u6548\u3001\u5b89\u5168\u6027\u548c\u7ed9\u836f\u9891\u7387\u3002TransCon\u751f\u957f\u6fc0\u7d20\uff08hGH\uff09\u6cbb\u7597\u513f\u7ae5\u751f\u957f\u6fc0\u7d20\u7f3a\u4e4f\u75c7\uff08GHD\uff09\u2162\u671f\u4e34\u5e8a\u7814\u7a76heiGHt\u7684\u79ef\u6781\u9876\u7ebf\u6570\u636e\u3002\u8be5\u7814\u7a76\u662f\u4e00\u9879\u968f\u673a\u3001\u5f00\u653e\u6807\u7b7e\u3001\u9633\u6027\u836f\u7269\u5bf9\u7167\u7814\u7a76\uff0c\u5c06\u6bcf\u5468\u4e00\u6b21TransCon hGH\u4e0e\u6bcf\u65e5\u4e00\u6b21hGH\uff08Genotropin\uff09\u8fdb\u884c\u4e86\u5bf9\u6bd4\u3002\u7ed3\u679c\u663e\u793a\uff0c\u8be5\u7814\u7a76\u8fbe\u5230\u4e86\u4e3b\u8981\u7ec8\u70b9\uff1a\u572852\u5468\u65f6\uff0cTransCon hGH\u5728\u5e74\u5316\u8eab\u9ad8\u901f\u7387\uff08AHV\uff0c\u5355\u4f4d\uff1a\u5398\u7c73\/\u5e74\uff09\u65b9\u9762\u5e76\u4e0d\u52a3\u4e8e\u6bcf\u65e5hGH\u5e76\u4e14\u8fd8\u4f18\u4e8e\u6bcf\u65e5hGH\u3002\u5177\u4f53\u6570\u636e\u4e3a\uff0c\u91c7\u7528\u534f\u65b9\u5dee\u5206\u6790\uff08ANCOVA\uff09\u610f\u5411\u6027\u6cbb\u7597\u7fa4\u4f53\uff0cTransCon hGH\u6cbb\u7597\u7ec4AHV\u4e3a11.2\u5398\u7c73\/\u5e74\uff0c\u6bcf\u65e5hGH\u4e3a10.3\u5398\u7c73\/\u5e74\uff0895%CI:0.22-1.50\uff0cp=0.0088\uff09\u3002\u5728\u6bcf\u6b21\u968f\u8bbf\u65f6\uff0cTransCon hGH\u6cbb\u7597\u7ec4AHV\u5747\u9ad8\u4e8e\u6bcf\u65e5hGH\u6cbb\u7597\u7ec4\uff0c\u6cbb\u7597\u5dee\u5f02\u4ece\u7b2c26\u5468\uff08\u5305\u62ec\u7b2c26\u5468\uff09\u5f00\u59cb\u5f97\u5230\u7edf\u8ba1\u5b66\u610f\u4e49\u3002TransCon hGH\u6cbb\u7597\u7ec4\u548c\u6bcf\u65e5hGH\u6cbb\u7597\u7ec4\u5e94\u7b54\u4e0d\u4f73\u7684\u60a3\u8005\u6bd4\u4f8b\uff08AHV\uff1c8.0\u5398\u7c73\/\u5e74\uff09\u5206\u522b\u4e3a4%\u548c11%\u3002\u7814\u7a76\u5b8c\u6210\u7684\u6240\u6709\u654f\u611f\u6027\u5206\u6790\u652f\u6301\u4e3b\u8981\u7ed3\u679c\uff0c\u8868\u660e\u8fd9\u4e9b\u7ed3\u679c\u7684\u7a33\u5065\u6027\u3002<\/span><\/p>\n

\u8be5\u7814\u7a76\u4e2d\uff0cTransCon hGH\u603b\u4f53\u5b89\u5168\uff0c\u8010\u53d7\u6027\u826f\u597d\uff0c\u4e0d\u826f\u4e8b\u4ef6\u4e0e\u6bcf\u65e5hGH\u6cbb\u7597\u7ec4\u89c2\u5bdf\u5230\u7684\u7c7b\u578b\u548c\u9891\u7387\u4e00\u81f4\uff0c\u4e14\u8bd5\u9a8c\u7ec4\u4e4b\u95f4\u5177\u6709\u53ef\u6bd4\u6027\u30022\u7ec4\u5747\u672a\u53d1\u73b0\u4e0e\u7814\u7a76\u836f\u7269\u76f8\u5173\u7684\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff0c\u6bcf\u4e2a\u6cbb\u7597\u7ec4\u89c2\u5bdf\u5230\u4e00\u4f8b\u4e25\u91cd\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TransCon hGH\u6cbb\u7597\u7ec4\u4e3a1.0%\uff0c\u6bcf\u65e5hGH\u6cbb\u7597\u7ec4\u4e3a1.8%\uff09\uff0c\u5747\u4e0e\u7814\u7a76\u836f\u7269\u65e0\u5173\u30022\u7ec4\u5747\u672a\u53d1\u73b0\u5bfc\u81f4\u7814\u7a76\u836f\u7269\u505c\u836f\u7684\u4e0d\u826f\u6cbb\u7597\u4e8b\u4ef6\u3002<\/span><\/p>\n

1.11 AXO-Lenti-PD<\/span><\/strong><\/p>\n

\u8fd1\u671f\uff0cAxovant\u516c\u53f8\u5ba3\u5e03\u5176\u5728\u7814\u57fa\u56e0\u7597\u6cd5\u5728\u4e00\u9879\u6cbb\u7597\u5e15\u91d1\u68ee\u75c7\u7684\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u53d6\u5f97\u4e86\u79ef\u6781\u7684\u65e9\u671f\u6570\u636e\u3002\u8be5\u7597\u6cd5\u7684\u5b89\u5168\u6027\u4e0e\u8010\u53d7\u6027\u5f97\u5230\u4e86\u9a8c\u8bc1\uff0c\u4e14\u6539\u5584\u4e86\u60a3\u8005\u7684\u8fd0\u52a8\u80fd\u529b\u8bc4\u5206\u3002\u672c\u6b21\u7814\u7a76\u4e2d\uff0c\u4e00\u9879\u540d\u4e3a\u201cAXO-Lenti-PD\u201d\u7684\u57fa\u56e0\u7597\u6cd5\u8ba9\u60a3\u8005\u4eec\u770b\u5230\u4e86\u5e0c\u671b\u3002\u4f7f\u7528\u6162\u75c5\u6bd2\u8f7d\u4f53\uff0c\u8fd9\u6b3e\u57fa\u56e0\u7597\u6cd5\u80fd\u5c06\u4e00\u7cfb\u5217\u5173\u952e\u7684\u9176\u9012\u9001\u8fdb\u60a3\u8005\u4f53\u5185\uff0c\u8f85\u52a9\u751f\u6210\u591a\u5df4\u80fa\u3002\u7406\u8bba\u4e0a\u8bf4\uff0c\u5b83\u6709\u671b\u91cd\u5851\u5927\u8111\u4e2d\u7684\u591a\u5df4\u80fa\u6c34\u5e73\uff0c\u4ece\u800c\u7f13\u89e3\u75c5\u60c5\u3002\u7814\u7a76\u4eba\u5458\u4eec\u671f\u671b\u901a\u8fc7\u7b80\u5355\u7684\u4e00\u6b21\u6cbb\u7597\uff0c\u5c31\u53ef\u4e3a\u60a3\u8005\u5e26\u6765\u591a\u5e74\u7684\u6cbb\u7597\u6548\u679c\u3002<\/span><\/p>\n

AXO-Lenti-PD\u7684\u4e00\u9879\u540d\u4e3aSUNRISE-PD\u7684\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u4eec\u8bc4\u4f30\u4e86\u8fd9\u6b3e\u57fa\u56e0\u7597\u6cd5\u7684\u6cbb\u7597\u6f5c\u529b\uff0c\u5e76\u5206\u6790\u4e86\u6700\u65e9\u63a5\u53d7\u6cbb\u7597\u76842\u540d\u665a\u671f\u5e15\u91d1\u68ee\u75c7\u60a3\u8005\u5728\u6cbb\u7597\u540e3\u4e2a\u6708\u7684\u6570\u636e\u3002\u5728\u7597\u6548\u65b9\u9762\uff0c\u7814\u7a76\u4eba\u5458\u4eec\u4f7f\u7528\u7684\u662f\u201c\u7edf\u4e00\u5e15\u91d1\u68ee\u75c7\u8bc4\u5b9a\u91cf\u8868\u201d\uff08UPDRS\uff09\u7b2c3\u90e8\u5206\u7684\u8bc4\u5206\uff0c\u5b83\u5e38\u88ab\u533b\u751f\u7528\u6765\u8bc4\u4f30\u8fd0\u52a8\u80fd\u529b\u3002\u5206\u6790\u8868\u660e\uff0c\u5728\u53bb\u9664\u5176\u4ed6\u7597\u6cd5\uff08\u5982\u5de6\u65cb\u591a\u5df4\uff09\u7684\u5f71\u54cd\u65f6\uff0c\u5904\u4e8e\u201cOFF\u201d\u671f\u7684\u60a3\u8005\uff0c\u5176\u8fd0\u52a8\u80fd\u529b\u90fd\u5f97\u5230\u4e86\u6539\u5584\u3002\u76f8\u8f83\u57fa\u7ebf\uff0c\u4ed6\u4eec\u7684\u6539\u5584\u5e45\u5ea6\u5e73\u5747\u8fbe42%\u3002\u5728\u5176\u4ed6\u7684\u4e00\u4e9b\u6307\u6807\u4e0a\uff0c\u7814\u7a76\u4eba\u5458\u4eec\u4e5f\u89c2\u5bdf\u5230\u4e86\u53ef\u559c\u7684\u6548\u679c\u3002\u8fd9\u4e9b\u65e9\u671f\u7684\u6570\u636e\u8868\u660eAXO-Lenti-PD\u6709\u6f5c\u529b\u4e3a\u665a\u671f\u5e15\u91d1\u68ee\u75c7\u60a3\u8005\u5e26\u6765\u663e\u8457\u7684\u8fd0\u52a8\u80fd\u529b\u6539\u5584\u3002<\/span><\/p>\n

1.12 MYO-101<\/span><\/strong><\/p>\n

Sarepta\u5236\u836f\u516c\u53f82\u578b\u80a2\u5e26\u578b\u808c\u8425\u517b\u4e0d\u826f\u75c7\uff08LGMD2E\uff09\u57fa\u56e0\u6cbb\u7597\u5019\u9009\u836f\u7269MYO-101\u57283\u540d\u60a3\u8005\u7684I\/IIa\u671f\u7814\u7a76\u4e2d\u5c55\u73b0\u4e86\u79ef\u6781\u7684\u9633\u6027\u7ed3\u679c\u3002\u8be5\u516c\u53f8\u7684\u57fa\u56e0\u6cbb\u7597\u5df2\u7ecf\u4f7f\u60a3\u8005\u4ea7\u751f\u4e86\u9ad8\u6c34\u5e73\u7684\u7f3a\u5931\u86cb\u767d\u8d28\u7684\u7a33\u5b9a\u8868\u8fbe\uff0c\u5e76\u5728Duchenne\u808c\u8425\u517b\u4e0d\u826f\u75c7\u548cLGMD2E\u4e2d\u4ea7\u751f\u4e86\u76f8\u5173\u751f\u7269\u6807\u5fd7\u7269\u7684\u5f3a\u70c8\u7ed3\u679c\u3002<\/span><\/p>\n

\u5728MYO-101\u7684\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c3\u540d4\u5c81\u81f313\u5c81\u7684\u513f\u7ae5\u5728\u63a5\u53d7MYO-101\u8f93\u6ce8\u7ea6\u4e24\u4e2a\u6708\u540e\uff0c\u6240\u6709\u60a3\u8005\u90fd\u8868\u73b0\u51fa\u03b2-sarcoglycan\uff08\u03b2-SG\uff09\u7684\u5f3a\u70c8\u8868\u8fbe\uff0c\u4e14\u03b2-SG\u6070\u5f53\u5730\u5b9a\u4f4d\u4e8e\u808c\u8089\u808c\u819c\u3002\u4e0e\u6b63\u5e38\u5bf9\u7167\u76f8\u6bd4\uff0c\u808c\u7ea4\u7ef4\u819c\u4e2d\u5e73\u5747\u8f6c\u5bfc\u7684\u03b2-SG\u86cb\u767d\u8868\u8fbe\u4e3a51\uff05\uff0c\u800c\u9884\u5148\u6307\u5b9a\u7684\u6210\u529f\u7387\u4e3a20\uff05\u3002\u540c\u65f6\uff0c\u6240\u6709\u53c2\u4e0e\u8005\u5747\u8868\u73b0\u51fa\u8840\u6e05\u808c\u9178\u6fc0\u9176\u6c34\u5e73\u7684\u663e\u8457\u4e0b\u964d\uff0c\u5e73\u5747\u4e0b\u964d\u8d85\u8fc790\uff05\u3002<\/span><\/p>\n

1.13 TLC590<\/span><\/strong><\/p>\n

\u8fd1\u671f\uff0c\u53f0\u5fae\u4f53\u516c\u53f8\u7814\u53d1\u7684\u672f\u540e\u957f\u6548\u6b62\u75db\u836f\u7269TLC590\u7684\u2160\/\u2161\u671f\u8bd5\u9a8c\u7ed3\u679c\u4eae\u773c\uff0cTLC590\u6b62\u75db\u6548\u679c\u957f\u8fbe96\u5c0f\u65f6\uff0c\u517c\u5177\u4e34\u5e8a\u53ca\u7edf\u8ba1\u610f\u4e49\u3002\u6b64\u968f\u673a\u5206\u7ec4\u3001\u53cc\u76f2\u3001\u6d3b\u6027\u5bf9\u7167\u836f\u3001\u5242\u91cf\u7d2f\u589e\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e3b\u8981\u8bc4\u4f3064\u4f4d\u63a5\u53d7\u759d\u6c14\u4fee\u8865\u624b\u672f\u7684\u60a3\u8005\u4f7f\u7528TLC590\u7684\u5b89\u5168\u6027\u53ca\u8010\u53d7\u6027\uff0c\u5206\u522b\u67094\u7ec4\u4e0d\u540c\u5242\u91cf\u7684TLC590\uff08190mg\u3001380mg\u3001475mg\u53ca590mg\uff09\u4ee5\u53ca1\u7ec4\u7f57\u6d3e\u5361\u56e0\u7684\u6d3b\u6027\u5bf9\u7167\u7ec4\uff08150mg\uff1b\u5242\u91cf\u76f8\u5f53\u4e8e90mg\u7684\u5e03\u6bd4\u5361\u56e0\uff09\u3002\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0cTLC590\u6240\u6709\u5242\u91cf\u7ec4\u7684\u6b62\u75db\u6548\u679c\u90fd\u4f18\u4e8e\u6d3b\u6027\u5bf9\u7167\u7ec4\uff0c\u800cTLC590\u7684475mg\u7ec4\u5728\u957f\u6548\u6b62\u75db\u6548\u679c\u65b9\u9762\u8868\u73b0\u8fdc\u4f18\u4e8e\u6d3b\u6027\u5bf9\u7167\u7ec4\uff0c\u4e14\u75bc\u75db\u6307\u6570\u5dee\u5f02\u5177\u6709\u4e34\u5e8a\u53ca\u7edf\u8ba1\u5b66\u4e0a\u7684\u663e\u7740\u610f\u4e49\u3002\u6b64\u5916\uff0cTLC590\u76f4\u5230168\u5c0f\u65f6\uff0c\u5176\u75bc\u75db\u6307\u6570\u4ecd\u4f4e\u4e8e\u6d3b\u6027\u5bf9\u7167\u7ec4\u300258.3%\u7684\u75c5\u60a3\u5728\u6574\u4e2a\u8bd5\u9a8c\u8fc7\u7a0b\u4e2d\u5b8c\u5168\u6ca1\u6709\u4f7f\u7528\u9e26\u7247\u7c7b\u6b62\u75db\u836f\u7269\u3002<\/span><\/p>\n

\u836f\u4ee3\u52a8\u529b\u5b66\u65b9\u9762\uff0cTLC590\u6709\u826f\u597d\u7684\u5242\u91cf\u4f9d\u8d56\u6027\u3002\u5b89\u5168\u6027\u65b9\u9762\uff0cTLC590\u6240\u6709\u5242\u91cf\u7ec4\u7684\u8010\u53d7\u6027\u826f\u597d\uff1b\u5176\u5b89\u5168\u6027\u4e0e\u6d3b\u6027\u5bf9\u7167\u7ec4\u63a5\u8fd1\u6216\u8f83\u4f4e\u3002\u6240\u6709\u4e0e\u6cbb\u7597\u76f8\u5173\u7684\u4e0d\u826f\u4e8b\u4ef6\uff0c\u5305\u62ec\u5934\u75db\u3001\u53cd\u80c3\u3001\u5455\u5410\u53ca\u4fbf\u79d8\uff0c\u7686\u5c5e\u8f7b\u5fae\u6027\uff0c\u4e14\u4e0a\u8ff0\u4e0d\u826f\u4e8b\u4ef6\u5728\u6d3b\u6027\u5bf9\u7167\u7ec4\u4e2d\u8f83\u4e3a\u5e38\u89c1\u3002\u8bd5\u9a8c\u4e2d\u6ca1\u6709\u4efb\u4f55\u4e0e\u6cbb\u7597\u76f8\u5173\u7684\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3001\u4ea6\u65e0\u5c40\u90e8\u9ebb\u9189\u5242\u9020\u6210\u7684\u5168\u8eab\u6027\u4e0d\u826f\u4e8b\u4ef6\u6216\u5bfc\u81f4\u53d7\u8bd5\u8005\u9000\u51fa\u7684\u4e0d\u826f\u4e8b\u4ef6\u3002\u5728\u7f8e\u56fd\uff0c\u9e26\u7247\u7c7b\u836f\u7269\u6ee5\u7528\u975e\u5e38\u4e25\u91cd\uff0c\u4eceTLC590\u53ef\u5ef6\u957f\u75c5\u4eba\u7b2c\u4e00\u6b21\u670d\u7528\u9e26\u7247\u7c7b\u6b62\u75db\u836f\u7269\u7684\u65f6\u95f4\u8fd9\u4e00\u70b9\u4e0a\uff0c\u4fbf\u663e\u73b0\u4e86TLC590\u5bf9\u6297\u9e26\u7247\u7c7b\u836f\u7269\u6ee5\u7528\u5371\u673a\u7684\u80fd\u529b\u3002<\/span><\/p>\n


<\/span><\/p>\n

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<\/section>\n
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2. \u4e34\u5e8a\u7814\u7a76\u7ed3\u679c\u4e0d\u4f73\u4e8b\u4ef6<\/span><\/span><\/span><\/span><\/span><\/strong><\/p>\n<\/section>\n<\/section>\n


<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u636e\u7edf\u8ba1\uff0c\u68c0\u7d22\u65f6\u95f4\u8303\u56f4\u5185\u670937\u4e2a\u836f\u7269\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\u4e0d\u4f73\uff08\u9644\u88682\uff09\uff0c\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u7684\u6cbb\u7597\u836f\u7269\u4ecd\u662f\u7814\u7a76\u8fdb\u5c55\u4e0d\u4f73\u4e8b\u4ef6\u7684\u91cd\u707e\u533a\uff0c\u670911\u4e2a\u836f\u7269\u6682\u505c\u7814\u53d1\uff0c\u5927\u591a\u662f\u65e0\u66f4\u65b0\u7684\u8fdb\u5c55\u88ab\u62a5\u9053\u3002\u8fd1\u671f\uff0cCerecin\u516c\u53f8AC-1204\u518d\u6b21\u542f\u52a8\u4e86\u4e00\u9879\u4e34\u5e8a\u2161\u671f\u8bd5\u9a8c\uff0c\u5728\u6b64\u4e4b\u524d\u76842017\u5e742\u670828\u65e5\uff0cAC-1204\u7684\u7528\u4e8e\u8f7b\u4e2d\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u60a3\u8005\u7684\u2162\u671f\u4e34\u5e8a\u4e2d\u672a\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\u3002\u53e6\u6709\u91cd\u5ea6\u6291\u90c1\u75c7\u836f\u7269Rapastinel\u672a\u6ee1\u8db3\u4e3b\u8981\u548c\u5173\u952e\u6b21\u8981\u7ec8\u70b9\u3001\u6297\u4f53-\u836f\u7269\u5076\u8054\u7269Mirvetuximab soravtansine\u7684\u2162\u671f\u7814\u7a76\u672a\u80fd\u8fbe\u5230\u5176\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u7684\u4e3b\u8981\u7ec8\u70b9\uff0c\u4e0b\u6587\u5bf9\u4e8c\u8005\u8fdb\u884c\u7b80\u8981\u4ecb\u7ecd\u3002<\/span>
<\/p>\n

2.1 Rapastinel<\/span><\/strong><\/p>\n

Rapastinel\u662f\u91cd\u5ea6\u6291\u90c1\u75c7\uff08MDD\uff09\u5019\u9009\u836f\u7269\uff0c\u7531Allergan\u516c\u53f8\u5f00\u53d1\u3002\u8fd1\u671f\uff0cAllergan\u516c\u5e03\u4e86\u2162\u671fRAP-MD-01\u3001RAP-MD-02\u548cRAP-MD-03\u7814\u7a76\u7684\u6700\u7ec8\u7ed3\u679c\uff0c\u79f0\u6cbb\u7597\u7ec4\u4e0e\u5b89\u6170\u5242\u7ec4\u5728\u4e3b\u8981\u548c\u5173\u952e\u6b21\u8981\u7ec8\u70b9\u4e0a\u672a\u4ea7\u751f\u663e\u8457\u5dee\u5f02\u3002\u6b64\u5916\uff0cAllergan\u516c\u53f8\u62a5\u544a\u6307\u51fa\uff0c\u5728\u590d\u53d1\u9884\u9632\u7814\u7a76\uff08RAP-MD-04\u7814\u7a76\uff09\u4e2d\u5bf9Rapastinel\u7684\u4e2d\u671f\u5206\u6790\u8868\u660e\uff0c\u4e3b\u8981\u548c\u5173\u952e\u6b21\u8981\u7ec8\u70b9\u4e5f\u4e0d\u4f1a\u5f97\u5230\u6ee1\u8db3\u3002\u5728RAP-MD-01\u548cRAP-MD-03\u7814\u7a76\u4e2d\uff0c\u5206\u522b\u62db\u52df\u4e86457\u540d\u548c415\u540d\u53c2\u4e0e\u8005\uff0cMDD\u60a3\u8005\u968f\u673a\u63a5\u53d7rapastinel\u6216\u5b89\u6170\u5242\u3002\u836f\u7269\u4ee5\u6bcf\u5468\u4e00\u6b21\u7684\u63a8\u6ce8\u9759\u8109\u5185\u6ce8\u5c04\u7ed9\u836f\uff0c\u800c\u60a3\u8005\u5728\u6574\u4e2a\u7814\u7a76\u671f\u95f4\u9700\u8981\u4fdd\u6301\u53e3\u670d\u6297\u6291\u90c1\u6cbb\u7597\u3002<\/span><\/p>\n

2.2 Mirvetuximab soravtansine<\/span><\/strong><\/p>\n

ImmunoGen\u5ba3\u5e03\uff0c\u9488\u5bf9\u53f6\u9178\u53d7\u4f53\uff08FR\uff09\u03b1\u9633\u6027\u3001\u94c2\u7c7b\u6297\u6027\u5375\u5de2\u764c\u60a3\u8005\u7684\u5b9e\u9a8c\u6027\u6297\u4f53-\u836f\u7269\u5076\u8054\u7269\uff08ADC\uff09Mirvetuximab soravtansine\u7684\u2162\u671f\u7814\u7a76\u672a\u80fd\u8fbe\u5230\u5176\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u7684\u4e3b\u8981\u7ec8\u70b9\u3002FORWARD\u8bd5\u9a8c\u968f\u673a\u5206\u914d\u4e86366\u540d\u60a3\u6709FR\u03b1\u9633\u6027\u3001\u94c2\u7c7b\u6297\u6027\u5375\u5de2\u764c\u7684\u60a3\u8005\u4ee5\u63a5\u53d7Mirvetuximab soravtansine\u6216\u533b\u751f\u9009\u62e9\u7684\u5355\u836f\u5316\u7597\u3002\u7ed3\u679c\u663e\u793a\uff0c\u5728\u6574\u4e2a\u7814\u7a76\u4eba\u7fa4\u4e2d\uff0cMirvetuximab soravtansine\u4e0e\u5316\u7597\u4e4b\u95f4\u7684PFS\u6216\u603b\u751f\u5b58\u7387\u7684\u4e3b\u8981\u7ec8\u70b9\u6ca1\u6709\u663e\u8457\u5dee\u5f02\uff0c\u5c3d\u7ba1\u4e24\u7ec4\u4e2d\u786e\u8ba4\u7684\u603b\u4f53\u53cd\u5e94\u7387\uff08ORR\uff09\u5206\u522b\u4e3a22\uff05\u548c12\uff05\u3002\u540c\u65f6\uff0c\u5728\u5177\u6709\u9ad8FR\u03b1\u8868\u8fbe\u7684\u60a3\u8005\u5b50\u96c6\uff08\u5360\u7814\u7a76\u4eba\u7fa4\u768460\uff05\uff09\u4e2d\uff0c\u4e0e\u5316\u7597\u76f8\u6bd4\uff0c\u63a5\u53d7Mirvetuximab soravtansine\u7684\u60a3\u8005\u7684PFS\u66f4\u957f\uff0c\u98ce\u9669\u6bd4\u4e3a0.69\u3002<\/span><\/p>\n

\u9644\u88681\uff1a\u8fd1\u4e00\u4e2a\u6708\uff082019\u5e742\u670815\u65e5\uff5e2019\u5e743\u670814\u65e5\uff09\u4e34\u5e8a\u8bd5\u9a8c\u6709\u79ef\u6781\u8fdb\u5c55\u7684\u836f\u7269<\/span><\/p>\n

\n

\"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u7814\u7a76\u8fdb\u5c55\u6982\u89c8\"<\/p>\n

\u9644\u88682\uff1a\u8fd1\u4e00\u4e2a\u6708\uff082019\u5e742\u670815\u65e5\uff5e2019\u5e743\u670814\u65e5\uff09\u4e34\u5e8a\u7814\u7a76\u8fdb\u5c55\u4e0d\u4f73\u7684\u836f\u7269<\/span><\/p>\n

\"\u8fd1\u4e00\u4e2a\u6708\u836f\u7269\u7814\u7a76\u8fdb\u5c55\u6982\u89c8\"<\/p>\n

<\/span><\/p>\n

\u3010\u53c2\u8003\u8d44\u6599\u3011<\/span><\/p>\n

1. Informa\u6570\u636e\u5e93\u53ca\u5176\u5b83\u7f51\u7edc\u516c\u5f00\u53ef\u83b7\u53d6\u8d44\u6e90\uff0c\u68c0\u7d22\u65e5\u671f\uff1a2019\u5e743\u670818\u65e5.<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

\u672c\u6587\u4f9d\u636eInforma\u6570\u636e\u5e93\u7edf\u8ba1\u8d44\u6599\uff0c\u68b3\u7406\u4e86\u8fd1\u4e00\u4e2a\u6708\uff082019\u5e742\u670815\u65e5\uff5e2019\u5e743\u670814\u65e5\uff09\u5728\u7814\u836f\u7269\u4e34\u5e8a […]<\/p>\n","protected":false},"author":1,"featured_media":82285,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/82284"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=82284"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/82284\/revisions"}],"predecessor-version":[{"id":82289,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/82284\/revisions\/82289"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/82285"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=82284"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=82284"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=82284"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}