{"id":82290,"date":"2019-03-29T00:00:50","date_gmt":"2019-04-11T06:59:35","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/82290\/"},"modified":"2019-04-11T14:59:37","modified_gmt":"2019-04-11T06:59:37","slug":"db4d631cf7","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/82290\/","title":{"rendered":"\u65b0\u578b\u836f\u7269\u9776\u6807\u96c6\u9526"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section class=\"_editor\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: left;\">\n<section style=\"display: inline-block;width: 100%;border-width: 1px;border-style: solid;border-color: transparent;background-image: url('http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/7-1554965977.png');background-position: 0% 0%;background-repeat: no-repeat;background-size: 20%;background-attachment: scroll;box-sizing: border-box;\" >\n<section style=\"display: inline-block;width: 100%;border-width: 1px;border-style: solid;border-color: transparent;background-image: url('http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/1-1554965977.png');background-position: 100% 100%;background-repeat: no-repeat;background-size: 20%;background-attachment: scroll;box-sizing: border-box;\" >\n<section style=\"display: inline-block;width: 100%;border-width: 1px;border-style: solid;border-color: transparent;background-image: url('http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/0-1554965977.png');background-position: 100% 100%;background-repeat: no-repeat;background-size: 10%;background-attachment: scroll;box-sizing: border-box;padding:10px;\" >\n<section style=\"box-shadow: #22a5ff 0px 0px 10px inset;background-color: rgba(231, 249, 255, 0.78);padding: 15px;box-sizing: border-box;\">\n<section style=\"margin:10px 10px 10px 10px;\">\n<p><span style=\"font-size: 15px;\">\u5bfc\u8bfb\uff1a\u672c\u6587\u5c06\u8fd1\u671f\u836f\u7269\u7814\u53d1\u65b0\u5174\u9776\u6807\u8fdb\u884c\u6c47\u603b\uff0c\u6db5\u76d6\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u548c\u795e\u7ecf\u7cbe\u795e\u9886\u57df\uff0c\u8fd9\u4e9b\u9776\u6807\u4e00\u822c\u662f\u8fd1\u671f\u62a5\u9053\u7684\u5177\u6709\u4e00\u5b9a\u6cbb\u7597\u6f5c\u529b\u7684\u65b0\u578b\u9776\u6807\uff0c\u4ee5\u671f\u4e3a\u79d1\u7814\u4eba\u5458\u63d0\u4f9b\u53c2\u8003\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"_editor\">\n<section style=\"text-align: center;\">\n<section style=\"display:inline-block;\">\n<section style=\"display: flex;flex-direction: column;align-items:center;\">\n<section style=\"padding: 5px 20px;border-bottom: 1px solid #000000;box-sizing: border-box;\">\n<p><span style=\"color: rgb(0, 213, 255);font-size: 17px;\"><strong>1. \u6982\u8ff0<\/strong><\/span><\/p>\n<\/section>\n<section style=\"width:36px;background: #fefefe;margin-top: -5px;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u8fd1\u671f\u56fd\u9645\u6709\u5f71\u54cd\u529b\u7684\u671f\u520a\u62a5\u9053\u4e86\u4e00\u4e9b\u65b0\u578b\u836f\u7269\u9776\u6807\uff0c\u672c\u6587\u5bf9\u90e8\u5206\u7528\u4e8e\u6cbb\u7597\u91cd\u5927\u75be\u75c5\u7684\u9776\u6807\u8fdb\u884c\u7edf\u8ba1\u5e76\u4f5c\u7b80\u8981\u4ecb\u7ecd\uff08\u88681\uff09\u3002\u540c\u65f6\uff0c\u4f9d\u636e\u79d1\u777f\u552f\u5b89Integrity\u6570\u636e\u5e93\uff08\u68c0\u7d22\u65e5\u671f\uff1a2019\u5e743\u670825\u65e5\uff09\uff0c\u5bf9\u8be5\u9776\u6807\u7684\u5728\u7814\u5019\u9009\u836f\u7269\u60c5\u51b5\u8fdb\u884c\u9610\u8ff0\uff08\u9644\u88681\uff09\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"          style=\"width: 100%;height: auto;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/4-1554965976.jpg\" alt=\"\u65b0\u578b\u836f\u7269\u9776\u6807\u96c6\u9526\" title=\"\u65b0\u578b\u836f\u7269\u9776\u6807\u96c6\u9526\"  \/><\/p>\n<section class=\"_editor\">\n<section style=\"text-align: center;\">\n<section style=\"display:inline-block;\">\n<section style=\"display: flex;flex-direction: column;align-items:center;\">\n<section style=\"padding: 5px 20px;border-bottom: 1px solid #000000;box-sizing: border-box;\">\n<p><span style=\"font-size: 17px;\"><strong><span style=\"color: rgb(0, 213, 255);\">2. \u80bf\u7624<\/span><\/strong><\/span><\/p>\n<\/section>\n<section style=\"width:36px;background: #fefefe;margin-top: -5px;\"><img class=\"\"     style=\"vertical-align: top;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/1-1554965976.gif\" alt=\"\u65b0\u578b\u836f\u7269\u9776\u6807\u96c6\u9526\" title=\"\u65b0\u578b\u836f\u7269\u9776\u6807\u96c6\u9526\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-indent: 2em;\"><strong><span style=\"font-size: 15px;\">2.1 ROR1<\/span><\/strong><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">3\u670813\u65e5\uff0c\u300aNature\u300b\u6b63\u520a\u5728\u7ebf\u53d1\u8868\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53d7\u4f53\u6fc0\u6d3b\u53ef\u9020\u6210\u4e73\u817a\u764c\u7684\u80bf\u7624\u5f02\u8d28\u6027\u548c\u8f6c\u79fb\uff08Ref 1\uff09\u3002\u540c\u65f6\uff0c\u7ecf\u8f6c\u5f55\u7ec4\u5b66\u3001\u86cb\u767d\u8d28\u7ec4\u5b66\u3001\u78f7\u9178\u5316\u86cb\u767d\u8d28\u7ec4\u5b66\u5206\u6790\u7ed3\u679c\u8868\u660e\uff0c\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53d7\u4f53\u53ef\u6fc0\u6d3b\u8f6c\u79fb\u7684\u591a\u4e2a\u6b65\u9aa4\uff0c\u4e14\u589e\u52a0\u916a\u6c28\u9178\u6fc0\u9176\u8de8\u819c\u53d7\u4f531\uff08ROR1\uff09\u8868\u8fbe\u6c34\u5e73\uff0c\u4e8c\u8005\u5747\u4e0e\u60a3\u8005\u751f\u5b58\u65f6\u95f4\u7f29\u77ed\u76f8\u5173\u3002\u6291\u5236ROR1\u8868\u8fbe\u4ee5\u540e\uff0c\u53ef\u51cf\u5c11\u4e34\u5e8a\u524d\u6a21\u578b\u7684\u8f6c\u79fb\u7076\u751f\u957f\uff0c\u5e76\u4e14\u5ef6\u957f\u60a3\u8005\u751f\u5b58\u65f6\u95f4\u3002\u8be5\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u5f53\u4f7f\u7528\u7cd6\u76ae\u8d28\u6fc0\u7d20\u6cbb\u7597\u4e73\u817a\u764c\u60a3\u8005\u764c\u75c7\u76f8\u5173\u5e76\u53d1\u75c7\u65f6\u9700\u8981\u8c28\u614e\uff0c\u800cROR1\u6709\u671b\u6210\u4e3a\u4e73\u817a\u764c\u8f6c\u79fb\u7684\u6cbb\u7597\u9776\u70b9\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><strong><span style=\"font-size: 15px;\">2.2 POLR2A<\/span><\/strong><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08TNBC\uff09\u662f\u552f\u4e00\u4e00\u79cd\u6ca1\u6709\u9776\u5411\u6cbb\u7597\u836f\u7269\u7684\u4e73\u817a\u764c\u3002\u4e0d\u8fc7\uff0c\u6700\u8fd1\u7f8e\u56fd\u9a6c\u91cc\u5170\u5927\u5b66\u5e15\u514b\u5206\u6821\u7684\u7814\u7a76\u663e\u793a\uff08Ref 2\uff09\uff0cPOLR2A\uff08RNA Polymerase \u2161 Subunit A\uff09\u53ef\u80fd\u4f1a\u6210\u4e3a\u672a\u6765\u6cbb\u7597TNBC\u7684\u9776\u70b9\u3002TP53\u662fTNBC\u4e2d\u6700\u5e38\u89c1\u7684\u7a81\u53d8\u6216\u7f3a\u5931\u57fa\u56e0\uff0c\u8ba1\u7b97\u673a\u5206\u6790\u663e\u793a\uff0cTP53\u90bb\u8fd1\u533a\u57df\u7684POLR2A\u6216\u80fd\u5b9e\u73b0TNBC\u7684\u9776\u5411\u6cbb\u7597\u3002\u636e\u6b64\uff0c\u7814\u7a76\u4eba\u5458\u8bbe\u8ba1\u4e86\u9776\u5411\u7eb3\u7c73\u7c92\u5b50\uff0c\u91ca\u653e\u9776\u5411POLR2A\u7684\u5c0f\u5e72\u6270RNA\uff08siRNA\uff09\u6291\u5236\u4e86\u5176\u8868\u8fbe\uff0c\u6210\u529f\u6291\u5236\u4e86\u80bf\u7624\u751f\u957f\uff0c\u63d0\u793a\u8fd9\u4e00\u9776\u70b9\u6709\u6210\u4e3aTNBC\u6cbb\u7597\u9776\u70b9\u7684\u6f5c\u529b\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><strong><span style=\"font-size: 15px;\">2.3 ARG2<\/span><\/strong><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">2\u670812\u65e5\uff0c\u300a Reports\u300b\u5728\u7ebf\u53d1\u8868\u7684\u7814\u7a76\u663e\u793a\uff0c\u764c\u7ec6\u80de\u4ec5\u901a\u8fc7\u7cbe\u6c28\u9178\u91762\uff08ARG2\uff09\u5408\u6210\u9e1f\u6c28\u9178\uff0c\u800c\u6b63\u5e38\u4e0a\u76ae\u7ec6\u80de\u53ef\u901a\u8fc7\u9e1f\u6c28\u9178\u8f6c\u6c28\u9176\uff08OAT\uff09\u5408\u6210\u9e1f\u6c28\u9178\uff08Ref 3\uff09\u3002\u6291\u5236ARG2\u7f16\u7801\u57fa\u56e0\u7684\u8868\u8fbe\u6c34\u5e73\uff0c\u53ef\u663e\u8457\u51cf\u5c11\u764c\u7ec6\u80de\u751f\u957f\uff0c\u5e76\u505c\u6ede\u4e8eG2M\u671f\uff0c\u800c\u65e0\u6cd5\u901a\u8fc7OAT\u8fdb\u884c\u4ee3\u507f\u3002\u6b64\u5916\uff0c\u8be5\u7814\u7a76\u5206\u6790\u4e86\u8d85\u8fc72000\u4f8b\u4eba\u7c7b\u4e73\u817a\u764c\u7684ARG2\u8868\u8fbe\u6c34\u5e73\uff0c\u7ed3\u679c\u53d1\u73b0ARG2\u9ad8\u8868\u8fbe\u4e8e\u7279\u5b9a\u4e73\u817a\u764c\u7c7b\u578b\uff0c\u4f8b\u5982\u96cc\u6fc0\u7d20\u53d7\u4f53\u9634\u6027\u7684\u57fa\u5e95\u6837\u4e73\u817a\u764c\uff0c\u5e76\u4e0e\u60a3\u8005\u4e0d\u826f\u751f\u5b58\u7ed3\u5c40\u5bc6\u5207\u76f8\u5173\uff0c\u800c\u96cc\u6fc0\u7d20\u53d7\u4f53\u9634\u6027\u7684\u57fa\u5e95\u6837\u4e73\u817a\u764c\u4e0e\u4e09\u9634\u6027\u4e73\u817a\u764c\u9ad8\u5ea6\u4ea4\u53c9\u91cd\u53e0\u3002\u8be5\u7814\u7a76\u8868\u660e\uff0c\u4ee3\u8c22\u4e0e\u7ec6\u80de\u5468\u671f\u4e4b\u95f4\u5b58\u5728\u76f8\u4e92\u5f71\u54cd\uff0cARG2\u6291\u5236\u5242\u7684\u4f7f\u7528\u6709\u671b\u6210\u4e3a\u4e09\u9634\u6027\u4e73\u817a\u764c\u7684\u4ee3\u8c22\u9776\u5411\u6cbb\u7597\u65b9\u6cd5\uff0c\u800c\u4e0d\u5f71\u54cd\u6b63\u5e38\u7ec6\u80de\u7684\u4ee3\u8c22\u548c\u751f\u957f\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><strong><span style=\"font-size: 15px;\">2.4 Siglec-15<\/span><\/strong><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u8fd1\u671f\uff0c\u7f8e\u56fd\u8036\u9c81\u5927\u5b66\u7684\u534e\u4eba\u79d1\u5b66\u5bb6\u9648\u5217\u5e73\u6559\u6388\u56e2\u961f\u53d1\u73b0\u4e86\u4e00\u6761\u5168\u65b0\u80bf\u7624\u514d\u75ab\u9003\u9038\u901a\u8def\uff0c\u5e76\u786e\u5b9a\u4e86\u672a\u6765\u514d\u75ab\u6cbb\u7597\u7684\u65b0\u9776\u6807\uff0c\u5176\u76f8\u5173\u7ed3\u679c\u53d1\u8868\u4e8e\u300aNature Medicine\u300b\u4e0a\uff08Ref 4\uff09\u3002\u7814\u7a76\u663e\u793a\uff0cSiglec-15\u53ef\u6301\u7eed\u5730\u6291\u5236T\u7ec6\u80de\u6d3b\u6027\uff0c\u540c\u65f6\uff0cSiglec-15\u57fa\u56e0\u6572\u9664\u540e\u5e76\u4e0d\u4f1a\u5bfc\u81f4\u5c0f\u9f20\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u6216\u5176\u4ed6\u75c7\u72b6\uff0c\u8868\u660e\u6291\u5236Siglec-15\u662f\u4e00\u6761\u76f8\u5bf9\u5b89\u5168\u7684\u6297\u764c\u9014\u5f84\u3002\u6b64\u5916\uff0c\u6297Siglec-15\u5355\u514b\u9686\u6297\u4f53\u03b1-S15\u53ef\u6210\u529f\u963b\u65adSiglec-15\u7684\u514d\u75ab\u6291\u5236\u4f5c\u7528\uff0c\u8fdb\u800c\u63d0\u9ad8\u4f53\u5185\u6297\u80bf\u7624\u514d\u75ab\u53cd\u5e94\u3002\u8fd9\u8868\u660eSiglec-15\u4f5c\u4e3a\u514d\u75ab\u6cbb\u7597\u65b0\u9776\u6807\u5177\u6709\u53ef\u884c\u6027\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><strong><span style=\"font-size: 15px;\">2.5 SOAT1<\/span><\/strong><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u809d\u7ec6\u80de\u764c\u662f\u5168\u7403\u764c\u75c7\u6b7b\u4ea1\u7684\u7b2c\u4e09\u5927\u539f\u56e0\u3002\u6211\u56fd\u5b66\u8005\u8fd1\u671f\u5728\u300aNature\u300b\u4e0a\u53d1\u8868\u7684\u7814\u7a76\u663e\u793a\uff08Ref 5\uff09\uff0c\u753e\u9187O-\u9170\u57fa\u8f6c\u79fb\u91761\uff08SOAT1\uff09\u7684\u8868\u8fbe\u6c34\u5e73\u4e0e\u809d\u764c\u60a3\u8005\u7684\u603b\u4f53\u751f\u5b58\u65f6\u95f4\u663e\u8457\u76f8\u5173\uff0c\u591a\u56e0\u7d20\u5206\u6790\u663e\u793aSOAT1\u662f\u65e9\u671f\u809d\u764c\u60a3\u8005\u7684\u72ec\u7acb\u9884\u540e\u56e0\u7d20\u3002\u540c\u65f6\uff0c\u7814\u7a76\u8bc1\u660eSOAT1\u7684\u4e00\u79cd\u5c0f\u5206\u5b50\u6291\u5236\u5242\u963f\u4f10\u9ea6\u5e03\uff08Avasimibe\uff09\u5728\u809d\u764c\u60a3\u8005\u7684\u4eba\u6e90\u80bf\u7624\u5f02\u79cd\u79fb\u690d\uff08PDX\uff09\u6a21\u578b\u4e0a\u8868\u73b0\u51fa\u826f\u597d\u7684\u6297\u80bf\u7624\u6548\u679c\uff0c\u4ece\u800c\u4ee5\u5b9e\u9a8c\u8868\u660e\u963f\u4f10\u9ea6\u5e03\u6709\u671b\u6210\u4e3a\u6cbb\u7597\u9884\u540e\u8f83\u5dee\u809d\u7ec6\u80de\u764c\u60a3\u8005\u7684\u9776\u5411\u6cbb\u7597\u836f\u7269\u3002\u6b64\u5916\uff0c\u7814\u7a76\u8fd8\u53d1\u73b0SOAT1\u7684\u86cb\u767d\u8d28\u8868\u8fbe\u6c34\u5e73\u5728\u7532\u72b6\u817a\u764c\u3001\u5934\u9888\u764c\u3001\u80c3\u764c\u3001\u80be\u764c\u548c\u524d\u5217\u817a\u764c\u4e2d\u5747\u548c\u60a3\u8005\u7684\u8f83\u5dee\u9884\u540e\u5bc6\u5207\u6b63\u76f8\u5173\uff0c\u8fdb\u800c\u6307\u51fa\u80c6\u56fa\u9187\u4ee3\u8c22\u5931\u7a33\u4e0eSOAT1\u7684\u4fc3\u764c\u673a\u5236\u5f88\u53ef\u80fd\u4e0d\u662f\u809d\u764c\u72ec\u6709\u7684\uff0c\u800c\u662f\u591a\u7c7b\u80bf\u7624\u4e2d\u4e00\u79cd\u5171\u6027\u7684\u6076\u53d8\u673a\u5236\uff0c\u56e0\u6b64\uff0c\u201c\u9776\u5411SOAT1\u53ef\u80fd\u4e3a\u66f4\u591a\u7c7b\u578b\u7684\u80bf\u7624\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6cbb\u7597\u7b56\u7565\u201d\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><strong><span style=\"font-size: 15px;\">2.6 \u8d85\u7ea7\u589e\u5f3a\u5b50<\/span><\/strong><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u7814\u7a76\u4eba\u5458\u8fd1\u65e5\u5728\u5305\u62ecc-MYC\u3001MED1\u3001OCT-4\u3001NANOG\u548cSOX2\u7b49\u57fa\u56e0\u7684\u589e\u5f3a\u5b50\u533a\u57df\u53d1\u73b0\u4e86\u5fae\u5c0f\u7684H3K27AC\u6807\u8bb0\uff0c\u53ef\u4f5c\u4e3a\u975e\u764c\u7684\u3001\u764c\u6027\u7684\u4ee5\u53ca\u8f6c\u79fb\u6027\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\uff08Pancreatic ductal adenocarcinoma\uff0cPDAC\uff09\u7ec6\u80de\u7cfb\u4e2d\u7684\u57fa\u56e0\u7c07\u7684\u4e00\u79cd\u8d85\u7ea7\u589e\u5f3a\u5b50\uff08Super-enhancers\uff0cSE\uff09\uff08Ref 6\uff09\u3002\u4e3b\u8f6c\u5f55\u56e0\u5b50OCT4\u3001SOX2\u548cNANOG\u5728\u9f20\u6e90\u80da\u80ce\u57fa\u56e0\u7ec4\u4e2d\u7684\u5171\u5b9a\u4f4d\u662f\u589e\u5f3a\u5b50\u6d3b\u6027\u7684\u9884\u6d4b\u56e0\u5b50\u3002\u7531\u4e8e\u7ec6\u80de\u4fe1\u53f7\u901a\u8def\u4e2d\u73b0\u5b58\u7684\u7f3a\u9677\u5141\u8bb8\u764c\u7ec6\u80de\u6539\u53d8\u5b83\u4eec\u589e\u6b96\u3001\u8f6c\u5f55\u3001\u751f\u957f\u3001\u8fc1\u79fb\u3001\u5206\u5316\u548c\u6b7b\u4ea1\u7684\u65b9\u5f0f\uff0c\u56e0\u6b64\uff0c\u53d1\u73b0\u764c\u7ec6\u80de\u589e\u6b96\u548c\u751f\u5b58\u4f9d\u8d56\u4e8eSE\u9a71\u52a8\u7684\u8f6c\u5f55\u4e3a\u9776\u5411\u764c\u7ec6\u80de\u63d0\u4f9b\u4e86\u4e00\u4e2a\u65b0\u7684\u6cbb\u7597\u9776\u70b9\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><strong><span style=\"font-size: 15px;\">2.7 Class Frizzled\u7684G\u86cb\u767d\u5076\u8054\u53d7\u4f53<\/span><\/strong><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u4e00\u9879\u520a\u767b\u5728\u300aNature Communications\u300b\u4e0a\u7684\u7814\u7a76\u63ed\u793a\u4e86\u764c\u75c7\u7a81\u53d8\u5f71\u54cd\u7ec6\u80de\u819c\u8868\u9762\u7279\u5b9a\u7c7b\u578b\u53d7\u4f53\u7684\u5206\u5b50\u673a\u5236\uff0c\u76f8\u5173\u7814\u7a76\u6216\u4e3a\u5f00\u53d1\u6cbb\u7597\u7279\u5b9a\u7c7b\u578b\u764c\u75c7\u7684\u4e2a\u4f53\u5316\u836f\u7269\u7597\u6cd5\u63d0\u4f9b\u65b0\u7684\u601d\u8def\uff0c\u6bd4\u5982\u76f4\u80a0\u764c\u548c\u80ba\u764c\u7b49\uff08Ref 7\uff09\u3002\u6587\u4e2d\uff0c\u91cd\u70b9\u5bf9\u4e00\u7c7b\u540d\u4e3aClass Frizzled\uff08Class F\uff09\u7684G\u86cb\u767d\u5076\u8054\u53d7\u4f53\u8fdb\u884c\u7814\u7a76\u3002\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u5229\u7528\u4e00\u79cd\u65b0\u5f00\u53d1\u7684\u65b9\u6cd5\u5bf9\u6bd4\u4e86\u80bf\u7624\u548c\u6b63\u5e38\u7fa4\u4f53\u4e2dClass F\u53d7\u4f53\u7a81\u53d8\u7684\u9891\u7387\uff0c\u5f53\u5c06\u764c\u75c7\u7a81\u53d8\u4e0e\u53d7\u4f53\u529f\u80fd\u76f8\u8054\u7cfb\u540e\uff0c\u7814\u7a76\u4eba\u5458\u6216\u8bb8\u5c31\u53d1\u73b0\u4e86\u57fa\u4e8e\u673a\u5236\u7684\u836f\u7269\u53d1\u73b0\u65b0\u65f6\u673a\uff0c\u4ed6\u4eec\u9996\u6b21\u63cf\u8ff0\u4e86Class F\u53d7\u4f53\u7684\u7279\u6b8a\u533a\u57df\u5982\u4f55\u626e\u6f14\u53d7\u4f53\u6fc0\u6d3b\u7684\u5f00\u5173\uff0c\u4ee5\u53ca\u8be5\u53d7\u4f53\u5206\u5b50\u7684\u7a81\u53d8\u5982\u4f55\u9a71\u52a8\u80bf\u7624\u7684\u53d1\u5c55\u3002\u9488\u5bf9\u8fd9\u4e00\u7ec4\u53d7\u4f53\u7684\u836f\u7269\u4e00\u76f4\u6ca1\u6709\u7279\u5f02\u6027\uff0c\u7814\u7a76\u8005\u5e0c\u671b\u672a\u6765\u80fd\u901a\u8fc7\u66f4\u4e3a\u6df1\u5165\u7684\u7814\u7a76\u5f00\u53d1\u51fa\u9776\u5411\u4f5c\u7528\u5355\u4e00\u53d7\u4f53\u7684\u6709\u6548\u836f\u7269\u4ee5\u53ca\u6cbb\u7597\u8bf8\u5982\u80ba\u764c\u7b49\u591a\u79cd\u764c\u75c7\u7684\u65b0\u578b\u836f\u7269\u7597\u6cd5\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><strong><span style=\"font-size: 15px;\">2.8 CYP\u5355\u52a0\u6c27\u9176<\/span><\/strong><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u8fd1\u65e5\uff0c\u6765\u81ea\u9a6c\u8428\u8bf8\u585e\u5927\u5b66\u963f\u9ed8\u65af\u7279\u5206\u6821\u7684\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u4e00\u79cd\u4ee3\u8c22\u7ec4\u5b66\u7684\u65b9\u6cd5\u53d1\u73b0\uff0c\u6c27\u5316\u5076\u6c2e\u7532\u70f7\uff08AOM\uff09\/\u53f3\u65cb\u7cd6\u9150\u786b\u9178\u916f\u94a0\uff08DSS\uff09\u8bf1\u5bfc\u7684\u7ed3\u80a0\u764c\u5c0f\u9f20\u8840\u6d46\u548c\u7ed3\u80a0\u4e2d\u7684\u73af\u6c27\u8102\u80aa\u9178\uff08EpFA\uff09\u7684\u542b\u91cf\u90fd\u5347\u9ad8\u4e86\uff0cEpFA\u662f\u7531\u7ec6\u80de\u8272\u7d20P450\uff08CYP\uff09\u5355\u52a0\u6c27\u9176\u4ea7\u751f\u7684\u7c7b\u4e8c\u5341\u70f7\u4ee3\u8c22\u4ea7\u7269\u3002CYP\u5355\u52a0\u6c27\u9176\u5728\u7ed3\u80a0\u80bf\u7624\u7ec4\u7ec7\u548c\u7ed3\u80a0\u764c\u7ec6\u80de\u4e2d\u9ad8\u8868\u8fbe\uff08Ref 8\uff09\u3002\u901a\u8fc7\u836f\u7269\u6291\u5236\u6216\u8005\u9057\u4f20\u5b66\u6e05\u9664CYP\u5355\u52a0\u6c27\u9176\u53ef\u6291\u5236AOM\/DSS\u8bf1\u5bfc\u5c0f\u9f20\u4f53\u5185\u4ea7\u751f\u7ed3\u80a0\u80bf\u7624\u3002\u6b64\u5916\uff0c\u5229\u752812,13-\u73af\u6c27\u5341\u516b\u70ef\u9178\uff08CYP\u5355\u52a0\u6c27\u9176\u4ee3\u8c22\u4e9a\u6cb9\u9178\u4ea7\u751f\u7684\u4ee3\u8c22\u7269\uff09\u5904\u7406\u7ec6\u80de\u4f1a\u589e\u52a0\u7ec6\u80de\u56e0\u5b50\u7684\u4ea7\u751f\u4ee5\u53caJNK\u78f7\u9178\u5316\uff0c\u8fd8\u4f1a\u52a0\u5267\u5c0f\u9f20\u4f53\u5185AOM\/DSS\u8bf1\u5bfc\u7684\u80bf\u7624\u7684\u4ea7\u751f\u3002\u8fd9\u4e9b\u6570\u636e\u8868\u660e\u8fc7\u53bb\u4e0d\u53d7\u91cd\u89c6\u7684CYP\u5355\u52a0\u6c27\u9176\u4fe1\u53f7\u901a\u8def\u88ab\u7ed3\u80a0\u764c\u4e0a\u8c03\uff0c\u5bfc\u81f4\u4e86\u764c\u75c7\u7684\u53d1\u751f\u548c\u53d1\u5c55\uff0c\u4e5f\u5c06\u662f\u9884\u9632\u6216\u6cbb\u7597\u7ed3\u80a0\u764c\u7684\u6f5c\u5728\u9776\u6807\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><strong><span style=\"font-size: 15px;\">2.9 GARP<\/span><\/strong><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u5c3d\u7ba1\u7ed3\u76f4\u80a0\u764c\u7684\u8bca\u65ad\u65b9\u9762\u53ef\u8c13\u5982\u65e5\u4e2d\u5929\uff0c\u4f46\u5176\u5728\u514d\u75ab\u6cbb\u7597\u65b9\u9762\u5374\u4ecd\u7136\u505c\u6ede\u4e0d\u524d\u3002\u8fd1\u65e5\uff0c\u5357\u5361\u7f57\u6765\u7eb3\u5927\u5b66\u7684\u4e00\u9879\u7814\u7a76\u7ed3\u679c\u6253\u7834\u4e86\u76ee\u524d\u7ed3\u76f4\u80a0\u60a3\u8005\u514d\u75ab\u6cbb\u7597\u7684\u50f5\u5c40\uff0c\u4ed6\u4eec\u53d1\u73b0\u4e86\u9488\u5bf9\u7ed3\u76f4\u80a0\u764c\u7684\u514d\u75ab\u6cbb\u7597\u7684\u65b0\u9776\u70b9\u2014\u2014GARP\uff08Glycoprotein-A repetitions predominant\uff09\uff0c\u7834\u574fGAR\u8c03\u8282\u7ec6\u80de\u4e0a\u7684\u7ec6\u80de\u8868\u9762\u53d7\u4f53GARP\u53ef\u964d\u4f4e\u514d\u75ab\u8010\u53d7\u6027\uff0c\u51cf\u5c11\u7ed3\u80a0\u764c\u7684\u53d1\u5c55\uff0c\u5e76\u5728\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\u6291\u5236Treg\u7ec6\u80de\u5411\u80a0\u9053\u7684\u8fc1\u79fb\uff08Ref 9\uff09\u3002\u5982\u679c\u7814\u7a76\u4eba\u5458\u80fd\u7814\u7a76\u6e05\u695a\u7ed3\u80a0\u764c\u7ec6\u80de\u5982\u4f55\u589e\u52a0Treg\u7ec6\u80de\u5f52\u5de2\u5230\u80a0\u9053\uff0c\u4fbf\u53ef\u963b\u6b62\u8be5\u5f52\u5de2\u4fe1\u53f7\uff0c\u8fd9\u5c06\u4f7f\u514d\u75ab\u7cfb\u7edf\u80fd\u591f\u627e\u5230\u5e76\u6839\u9664\u80bf\u7624\u7ec6\u80de\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><strong><span style=\"font-size: 15px;\">2.10 \u95f4\u76ae\u7d20<\/span><\/strong><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u4e2d\u56fd\u79d1\u5b66\u9662\u5e7f\u5dde\u751f\u7269\u533b\u836f\u4e0e\u5065\u5eb7\u7814\u7a76\u9662\u674e\u9e4f\u7814\u7a76\u7ec4\u5728\u300aJournal of Hematology &amp; Oncology\u300b\u4e0a\u53d1\u8868\u7684\u65b0\u7814\u7a76\u663e\u793a\uff0c\u95f4\u76ae\u7d20\uff08MSLN\uff0cMesothelin\uff09\u53ef\u4f5c\u4e3aCAR-T\u6cbb\u7597\u80c3\u764c\u7684\u6709\u6548\u65b0\u9776\u70b9\uff08Ref 10\uff09\u3002\u7814\u7a76\u4e2d\u7684\u4f53\u5185\u5c3e\u9759\u8109\u6a21\u578b\u548c\u8179\u8154\u6a21\u578b\u7b49\u591a\u4e2a\u6a21\u578b\u8868\u660e\uff0cM28z10 T\u7ec6\u80de\u80fd\u660e\u663e\u6291\u5236\u80bf\u7624\u7684\u751f\u957f\uff0c\u751a\u81f3\u5728\u90e8\u5206\u5c0f\u9f20\u4f53\u5185\u8fbe\u5230\u5b8c\u5168\u6e05\u9664\u80bf\u7624\u7684\u6548\u679c\uff0c\u4ece\u800c\u5ef6\u957f\u5c0f\u9f20\u751f\u5b58\u671f\u3002\u5728\u5c0f\u9f20\u76ae\u4e0b\u6210\u7624\u6a21\u578b\u4e2d\uff0c\u8be5\u7ec4\u7814\u7a76\u4eba\u5458\u8fd8\u53d1\u73b0\uff0cM28z10 T\u7684\u76ae\u4e0b\u6ce8\u5c04\u65b9\u5f0f\u4e0e\u5c3e\u9759\u8109\u6ce8\u5c04\u65b9\u5f0f\u76f8\u6bd4\uff0c\u80fd\u5728\u5b9e\u9a8c\u65e9\u671f\u663e\u8457\u63d0\u9ad8T\u7ec6\u80de\u5728\u80bf\u7624\u7684\u6d78\u6da6\u6bd4\u4f8b\uff0c\u4ece\u800c\u8fbe\u5230\u66f4\u5feb\u901f\u6709\u6548\u7684\u6291\u5236\u6548\u679c\uff0c\u63d0\u793a\u4e34\u5e8a\u4e2d\u764c\u65c1\u3001\u7624\u5185\u6ce8\u5c04\u7b49\u5c40\u90e8\u6ce8\u5c04\u65b9\u5f0f\u53ef\u80fd\u4f1a\u6709\u6548\u63d0\u9ad8\u6cbb\u7597\u6548\u679c\u3002\u8be5\u7814\u7a76\u7684\u591a\u4e2a\u6a21\u578b\u8bc1\u660e\u4e86MSLN\u4f5c\u4e3a\u80c3\u764cCAR-T\u7597\u6cd5\u65b0\u9776\u70b9\u7684\u6709\u6548\u6027\uff0c\u540c\u65f6\u5728\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u521d\u6b65\u63a2\u7d22\u4e86\u6ce8\u5c04\u65b9\u5f0f\u5bf9\u6cbb\u7597\u6548\u679c\u7684\u63d0\u5347\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><strong><span style=\"font-size: 15px;\">2.11 EZH2<\/span><\/strong><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u8fd1\u65e5\uff0c\u82f1\u56fd\u79d1\u5b66\u5bb6\u53d1\u73b0\u4e00\u79cd\u540d\u4e3aEZH2\uff08Enhancer of zeste homologue 2\uff09\u7684\u8868\u89c2\u9057\u4f20\u86cb\u767d\u8d28\u53ef\u5ef6\u7f13\u6025\u6027\u9ad3\u6027\u767d\u8840\u75c5\uff08AML\uff09\u7684\u53d1\u5c55\uff0c\u4ed6\u4eec\u5728\u7ebf\u53d1\u8868\u5728\u300aJournal of Experimental Medicine\u300b\u7684\u7814\u7a76\u8868\u660e\uff0c\u9776\u5411EZH2\u53ef\u80fd\u4e3aAML\u63d0\u4f9b\u4e86\u4e00\u79cd\u5f88\u6709\u524d\u9014\u7684\u65b0\u6cbb\u7597\u65b9\u6cd5\uff0c\u8fd9\u662f\u8868\u89c2\u9057\u4f20\u5728\u8840\u6db2\u80bf\u7624\u6cbb\u7597\u65b9\u9762\u7684\u4e00\u5927\u7a81\u7834\uff08Ref 11\uff09\u3002EZH2\u662fPCG\u86cb\u767d\u5bb6\u65cfPRC2\u590d\u5408\u7269\u7684\u50ac\u5316\u4e9a\u57fa\uff0c\u5b83\u901a\u8fc7\u7532\u57fa\u5316\u4fee\u9970\u4f5c\u7528\u6765\u6c89\u9ed8\u9776\u57fa\u56e0\u7684\u8868\u8fbe\u3002\u5c0f\u9f20\u6a21\u578b\u8bd5\u9a8c\u53d1\u73b0\uff0c\u5728\u75be\u75c5\u7684\u65e9\u671f\u548c\u665a\u671f\uff0c\u8fd9\u79cd\u86cb\u767d\u8c03\u8282\u7684\u57fa\u56e0\u7ec4\u5408\u51e0\u4e4e\u5b8c\u5168\u4e0d\u540c\u3002\u5728\u6025\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\u7684\u521d\u671f\uff0cEZH2\u7684\u4e22\u5931\u4f1a\u5bfc\u81f4\u7ec6\u80de\u589e\u52a0\u4e00\u79cd\u53eb\u505aPlag1\u7684\u8f6c\u5f55\u56e0\u5b50\u7684\u4ea7\u751f\uff0c\u4ece\u800c\u52a0\u901f\u767d\u8840\u75c5\u7684\u53d1\u5c55\uff0c\u4f46\u5728\u6025\u6027\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\u665a\u671f\u6291\u5236EZH2\u5bf9Plag1\u6c34\u5e73\u5374\u5e76\u6ca1\u6709\u5f71\u54cd\u3002\u540c\u65f6\uff0c\u4f53\u5916\u5b9e\u9a8c\u8868\u660e\uff0c\u6291\u5236EZH2\u8fd8\u80fd\u963b\u6b62\u4ece\u60a3\u8005\u4f53\u5185\u5206\u79bb\u51fa\u6765\u7684\u6025\u6027\u9ad3\u7ec6\u80de\u7684\u751f\u957f\u3002<\/span><\/p>\n<section class=\"_editor\">\n<section style=\"text-align: center;\">\n<section style=\"display:inline-block;\">\n<section style=\"display: flex;flex-direction: column;align-items:center;\">\n<section style=\"padding: 5px 20px;border-bottom: 1px solid #000000;box-sizing: border-box;\">\n<p><span style=\"color: rgb(0, 213, 255);font-size: 17px;\"><strong>3.\u81ea\u8eab\u514d\u75ab<\/strong><\/span><\/p>\n<\/section>\n<section style=\"width:36px;background: #fefefe;margin-top: -5px;\"><img class=\"\"     style=\"vertical-align: top;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/0-1554965976.gif\" alt=\"\u65b0\u578b\u836f\u7269\u9776\u6807\u96c6\u9526\" title=\"\u65b0\u578b\u836f\u7269\u9776\u6807\u96c6\u9526\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-indent: 2em;\"><strong><span style=\"font-size: 15px;\">3.1 ELMO1<\/span><\/strong><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u5728\u8fd1\u671f\u7684\u300aNature Immunology\u300b\u6742\u5fd7\u4e0a\uff0c\u6765\u81ea\u5f17\u5409\u5c3c\u4e9a\u5927\u5b66\u7684\u4e00\u9879\u7814\u7a76\u663e\u793a\uff0c\u901a\u8fc7\u7814\u7a76\u5c0f\u9f20\u5173\u8282\u708e\u6a21\u578b\u7279\u5b9a\u7684\u541e\u566c\u901a\u8def\uff0c\u53d1\u73b0\u541e\u566c\u4fe1\u53f7\u86cb\u767dELMO1\uff08Engulfment and cell motility protein 1\uff09\u7684\u4e27\u5931\uff0c\u4f1a\u8c03\u8282\u4e2d\u6027\u7c92\u7ec6\u80de\u52df\u96c6\uff0c\u51cf\u8f7b\u5173\u8282\u708e\u81f4\u75c5\u7684\u4e25\u91cd\u6027\uff08Ref 12\uff09\u3002\u901a\u8fc7\u86cb\u767d\u8d28\u7ec4\u5b66\u548c\u8f6c\u5f55\u7ec4\u5b66\u65b9\u6cd5\uff0c\u63ed\u793a\u4e86\u55dc\u4e2d\u6027\u7c92\u7ec6\u80de\u4f9d\u8d56ELMO1\u7684\u7279\u5f81\uff0c\u5e76\u786e\u5b9aELMO1\u5728\u5173\u8282\u708e\u76f8\u5173\u5206\u5b50C5a\u548cLTB4\u53d7\u4f53\u4e0b\u6e38\u4fe1\u53f7\u4f20\u5bfc\u7684\u673a\u5236\u3002\u540c\u65f6\uff0c\u901a\u8fc7\u5bf9\u5c0f\u9f20\u6a21\u578b\u7814\u7a76\uff0c\u53d1\u73b0\u963b\u65adELMO1\u80fd\u51cf\u8f7b\u5173\u8282\u708e\u75c7\u72b6\uff0c\u4e14\u4e0d\u4f1a\u5f15\u8d77\u5176\u5b83\u5e76\u53d1\u75c7\u3002\u8fd9\u4e00\u7814\u7a76\u7ed3\u679c\u4e3a\u6cbb\u7597\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u63d0\u51fa\u4e86\u65b0\u7684\u601d\u8def\uff0c\u4e5f\u53ef\u80fd\u901a\u8fc7\u4e00\u79cd\u7b80\u5355\u7684\u8840\u6db2\u68c0\u6d4b\u6765\u6d4b\u5b9a\u98ce\u6e7f\u6027\u5173\u8282\u708e\u75be\u75c5\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><strong><span style=\"font-size: 15px;\">3.2 PAI-1<\/span><\/strong><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u708e\u75c7\u6027\u80a0\u75c5\uff08IBD\uff09\u662f\u4e00\u79cd\u7279\u53d1\u6027\u80a0\u9053\u708e\u6027\u75be\u75c5\uff0c\u5305\u62ec\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u548c\u514b\u7f57\u6069\u75c5\u7b49\u3002\u8fd1\u671f\uff0c\u534e\u76db\u987f\u5927\u5b66\u533b\u5b66\u9662\u7684\u7814\u7a76\u4eba\u5458\u5206\u6790\u4e86\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u548c\u514b\u7f57\u6069\u75c5\u60a3\u8005\u7ed3\u80a0\u7ec4\u7ec7\u7684\u57fa\u56e0\u8868\u8fbe\u6a21\u5f0f\uff0c\u7ed3\u679c\u663e\u793a\uff0c\u5bf9\u4e8e\u4e25\u91cd\u7684IBD\u60a3\u8005\uff0c\u7531SERPINE1\u57fa\u56e0\u7f16\u7801\u7684\u51dd\u8840\u76f8\u5173\u86cb\u767dPAI-1\uff08Plasminogen activator inhibitor-1\uff09\u7684\u6d3b\u6027\u4e5f\u5347\u9ad8\uff08Ref 13\uff09\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u66f4\u591a\u7684\u5c0f\u9f20\u7814\u7a76\u53d1\u73b0\uff0cPAI-1\u901a\u8fc7\u4e0e\u7ec4\u7ec7\u7ea4\u6eb6\u9176\u539f\u6fc0\u6d3b\u7269\uff08tPA\uff09\u86cb\u767d\u7684\u76f8\u4e92\u4f5c\u7528\u6765\u4fc3\u8fdb\u708e\u75c7\uff0ctPA\u901a\u5e38\u9884\u9632\u7ed3\u80a0\u708e\u548c\u7c98\u819c\u635f\u4f24\u3002PAI-1\u901a\u8fc7\u963b\u65adtPA\u4ecb\u5bfc\u7684\u5207\u5272\u53ca\u6297\u708e\u6027TGF-\u03b2\u7684\u6fc0\u6d3b\u800c\u52a0\u5267\u4e86\u7c98\u819c\u635f\u4f24\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0cPAI-1\u6c34\u5e73\u7684\u589e\u9ad8\u53ef\u80fd\u5bfc\u81f4\u4e86\u66f4\u5177\u4fb5\u88ad\u6027\u7684\u75be\u75c5\uff0c\u4f46\u4e5f\u8868\u660e\u5b83\u6709\u671b\u6210\u4e3a\u6cbb\u7597\u9776\u70b9\u3002<\/span><\/p>\n<section class=\"_editor\">\n<section style=\"text-align: center;\">\n<section style=\"display:inline-block;\">\n<section style=\"display: flex;flex-direction: column;align-items:center;\">\n<section style=\"padding: 5px 20px;border-bottom: 1px solid #000000;box-sizing: border-box;\">\n<p><span style=\"color: rgb(0, 213, 255);font-size: 17px;\"><strong>4.\u795e\u7ecf\u7cbe\u795e<\/strong><\/span><\/p>\n<\/section>\n<section style=\"width:36px;background: #fefefe;margin-top: -5px;\"><img class=\"\"     style=\"vertical-align: top;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/6-1554965976.gif\" alt=\"\u65b0\u578b\u836f\u7269\u9776\u6807\u96c6\u9526\" title=\"\u65b0\u578b\u836f\u7269\u9776\u6807\u96c6\u9526\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-indent: 2em;\"><strong><span style=\"font-size: 15px;\">4.1 eEF2K<\/span><\/strong><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u7f8e\u56fdWake Forest School of Medicine\u7684\u7814\u7a76\u4eba\u5458\u5728\u300aJournal of Clinical Investigation\u300b\u4e0a\u7684\u6700\u65b0\u7814\u7a76\u663e\u793a\uff0ceEF2K\uff08Eukaryotic elongation factor 2 kinase\uff09\u7684\u57fa\u56e0\u6291\u5236\u53ef\u9632\u6b62\u5c0f\u9f20\u8bb0\u5fc6\u4e27\u5931\u5e76\u663e\u8457\u6539\u5584\u5b83\u4eec\u7684\u7a81\u89e6\u529f\u80fd\uff08Ref 14\uff09\u3002eEF2K\u53d7\u5230AMPK\u6fc0\u9176\u8c03\u63a7\uff0c\u5f71\u54cdeEF2\uff08Eukaryotic elongation factor 2\uff09\u7684\u78f7\u9178\u5316\uff0c\u8c03\u63a7\u4e00\u822c\u86cb\u767d\u8d28\u7684\u5408\u6210\u3002mTORC1\u8fd8\u901a\u8fc7\u76f4\u63a5\u6216\u5176\u4e0b\u6e38S6K1\u6291\u5236eEF2K\u5e76\u6291\u5236eEF2\u78f7\u9178\u5316\u6765\u63a7\u5236\u7ffb\u8bd1\u5ef6\u4f38\u3002eEF2K\u552f\u4e00\u5df2\u77e5\u7684\u5e95\u7269\u662feEF2\uff0c\u8fd9\u79cd\u7279\u5f02\u6027\u4f7f\u5176\u6210\u4e3a\u6cbb\u7597AD\u907f\u514d\u8131\u9776\u6548\u5e94\u7684\u9776\u70b9\u3002\u8fd9\u4e00\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0ceEF2K\u6709\u671b\u6210\u4e3a\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u7684\u6cbb\u7597\u65b0\u9776\u70b9\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"          style=\"width: 100%;height: auto;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/10-1554965976.jpg\" alt=\"\u65b0\u578b\u836f\u7269\u9776\u6807\u96c6\u9526\" title=\"\u65b0\u578b\u836f\u7269\u9776\u6807\u96c6\u9526\"  \/><\/p>\n<p style=\"text-indent: 2em;text-align: center;\"><br  \/><\/p>\n<p style=\"text-indent: 0em;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">\u53c2\u8003\u8d44\u6599<\/span><\/p>\n<p style=\"text-indent: 0em;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">1. \u79d1\u777f\u552f\u5b89Integrity\u6570\u636e\u5e93, \u68c0\u7d22\u65e5\u671f: 2019\u5e743\u670825\u65e5.<\/span><\/p>\n<p style=\"text-indent: 0em;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">2. \u5404\u516c\u5f00\u7f51\u7edc\u76f8\u5173\u62a5\u9053.<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u5bfc\u8bfb\uff1a\u672c\u6587\u5c06\u8fd1\u671f\u836f\u7269\u7814\u53d1\u65b0\u5174\u9776\u6807\u8fdb\u884c\u6c47\u603b\uff0c\u6db5\u76d6\u80bf\u7624\u3001\u81ea\u8eab\u514d\u75ab\u548c\u795e\u7ecf\u7cbe\u795e\u9886\u57df\uff0c\u8fd9\u4e9b\u9776\u6807\u4e00\u822c\u662f\u8fd1\u671f\u62a5\u9053\u7684\u5177\u6709\u4e00\u5b9a\u6cbb [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":82291,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/82290"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=82290"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/82290\/revisions"}],"predecessor-version":[{"id":82300,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/82290\/revisions\/82300"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/82291"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=82290"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=82290"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=82290"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}