{"id":82312,"date":"2019-03-27T00:00:50","date_gmt":"2019-04-11T06:59:46","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/82312\/"},"modified":"2019-04-11T14:59:50","modified_gmt":"2019-04-11T06:59:50","slug":"7f229e2a38","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/82312\/","title":{"rendered":"\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7814\u7a76\u8fdb\u5c55"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section class=\"_editor\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"border: 1px solid rgb(128, 177, 53);border-radius: 5px;padding: 3px;\">\n<section style=\"border: 1px solid rgb(128, 177, 53);border-radius: 5px;padding: 3px;\">\n<section style=\"border: 1px solid rgb(128, 177, 53);border-radius: 5px;padding: 15px;\">\n<p style=\"line-height: 1.75em;letter-spacing: 2px;\"><sapn style=\"font-size:16px;\"><\/sapn><sapn style=\"font-size:16px;\"><\/sapn><sapn 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style=\"font-size:16px;\"><\/sapn><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"_editor\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<p style=\"text-align: center;width:2em;margin-left:auto;margin-right:auto;\">\n<section style=\"text-align: center;\">\n<section style=\"margin-top: -20px;border-style: solid;border-width: 1px;border-color: #24b37a;padding: 2px;display: inline-block;box-sizing: border-box;\">\n<section style=\"border-style: dotted;border-width: 1px;border-color: #24b37a;padding: 2px 10px;display: inline-block;box-sizing: border-box;\">\n<p style=\"letter-spacing: 2px;\"><span style=\"color: rgb(0, 209, 0);\"><strong>\u6cbb\u7597\u836f\u7269<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 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15px;\">\u5168\u7403\u5df2\u4e0a\u5e02\u7684\u6297\u7cbe\u795e\u75c5\u836f\u7269\u5171\u8ba155\u79cd\uff0c\u5305\u62ec35\u79cd\u5178\u578b\u6297\u7cbe\u795e\u75c5\u836f\uff08\u5927\u591a\u662f\u7279\u5f02\u6027\u591a\u5df4\u80faD2\u53d7\u4f53\u62ee\u6297\u5242\uff09\u548c20\u79cd\u591a\u9776\u70b9\uff08\u5982\u591a\u5df4\u80faD2\u548c5-HT2A\u53cc\u91cd\u62ee\u6297\u5242\u3001D2\/D3\u90e8\u5206\u6fc0\u52a8\u5242\uff09\u7684\u975e\u5178\u578b\u6297\u7cbe\u795e\u75c5\u836f\u3002\u8be5\u7c7b\u836f\u7269\u5e02\u573a\u53d7\u91cd\u78c5\u836f\u7269\u4e13\u5229\u5230\u671f\u5f71\u54cd\uff0c\u81ea2013\u5e74\u4ee5\u6765\u4e00\u76f4\u5728\u840e\u7f29\uff0c\u4ece2013\u5e74\u7684210\u4ebf\u7f8e\u5143\u964d\u81f32017\u5e74\u7684181\u4ebf\u7f8e\u5143\uff0c\u5e15\u6f58\u7acb\u916e\u68d5\u6988\u9178\u916f\u3001\u9c81\u62c9\u897f\u916e\u3001\u963f\u7acb\u54cc\u5511\u3001\u55b9\u786b\u5e73\u3001\u5229\u57f9\u916e\u3001\u5965\u6c2e\u5e732017\u5e74\u7684\u9500\u552e\u5747\u8d85\u8fc710\u4ebf\u7f8e\u5143\u3002\u6211\u56fd\u8be5\u7c7b\u5e02\u573a\u5728\u6301\u7eed\u589e\u957f\uff0c\u4f46\u89c4\u6a21\u5c1a\u5c0f\uff0c2017\u5e74\u5e02\u573a\u8fbe6.3\u4ebf\u7f8e\u5143\u3002\u9500\u552e\u6700\u597d\u7684\u54c1\u79cd\u662f\u5965\u6c2e\u5e73\uff0c\u5e74\u9500\u552e\u989d\u8fbe2.6\u4ebf\u7f8e\u5143\uff08\u56fe1\uff09\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"width: 100%;height: auto;\"    src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/5-1554965987.jpeg\" alt=\"\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7814\u7a76\u8fdb\u5c55\" title=\"\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7814\u7a76\u8fdb\u5c55\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\">\u56fe1\uff1a2017\u5e74\u5168\u7403\u548c\u4e2d\u56fd\u9500\u552e\u524d\u5341\u7684\u6297\u7cbe\u795e\u75c5\u836f\u7269\uff08\u767e\u4e07\u7f8e\u5143\uff09<\/span><\/p>\n<section class=\"_editor\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<p style=\"text-align: center;width:2em;margin-left:auto;margin-right:auto;\"><img   class=\"\"   src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/10-1554965987.png\" alt=\"\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7814\u7a76\u8fdb\u5c55\" title=\"\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7814\u7a76\u8fdb\u5c55\"  \/><\/p>\n<section style=\"text-align: center;\">\n<section style=\"margin-top: -20px;border-style: solid;border-width: 1px;border-color: #24b37a;padding: 2px;display: inline-block;box-sizing: border-box;\">\n<section style=\"border-style: dotted;border-width: 1px;border-color: #24b37a;padding: 2px 10px;display: inline-block;box-sizing: border-box;\">\n<p style=\"letter-spacing: 2px;\"><span style=\"color: rgb(0, 209, 0);\"><strong><span style=\"font-size: 15px;\">\u91cd\u8981\u9776\u70b9\u673a\u5236\u53ca\u836f\u7269\u4ecb\u7ecd<\/span><\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u636eInforma\u6570\u636e\u5e93\u7edf\u8ba1\uff0c\u76ee\u524d\u4e34\u5e8a\u5728\u7814\u7684\u6297\u7cbe\u795e\u5206\u88c2\u75c7\u836f\u7269\u5171\u8ba149\u4e2a\uff0cIntra-ular 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15px;\">\u975e\u5178\u578b\u6297\u7cbe\u795e\u75c5\u836f\u7269\u5927\u591a\u5bf95-\u7f9f\u8272\u80fa\u53d7\u4f53\u548c\u591a\u5df4\u80fa\u53d7\u4f53\u5177\u6709\u53cc\u91cd\u4f5c\u7528\u3002\u91cd\u78c5\u836f\u7269\u963f\u7acb\u54cc\u5511\u5bf95-HT1A\u30015-HT2A\u3001D2\u548cD3\u53d7\u4f53\u5747\u6709\u9ad8\u5ea6\u4eb2\u548c\u529b\uff0c\u4e3aD2\u3001D3\u548c5-HT1A\u53d7\u4f53\u90e8\u5206\u6fc0\u52a8\u5242\uff0c5-HT2A\u53d7\u4f53\u62ee\u6297\u5242\u30022016\u5e74FDA\u6279\u51c6\u7684\u6210\u4eba\u7cbe\u795e\u5206\u88c2\u75c7\u548c\u2160\u578b\u53cc\u76f8\u60c5\u611f\u969c\u788d\u6cbb\u7597\u836f\u7269\u5361\u5229\u62c9\u55ea\uff0c\u4e3aD3\u504f\u7231\u578b\u591a\u5df4\u80faD3\/D2\u53d7\u4f53\u90e8\u5206\u6fc0\u52a8\u5242\uff0c\u5e76\u5bf95-HT2A\u53d7\u4f53\u5177\u6709\u9002\u5ea6\u4eb2\u548c\u6027\u3002\u9488\u5bf9\u8be5\u673a\u5236\u7684\u5019\u9009\u836f\u7269\u5df2\u6709\u591a\u4e2a\u5904\u4e8e\u4e34\u5e8a\u540e\u671f\u7814\u53d1\u4e2d\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><strong><span style=\"font-size: 15px;\">Lumateperone<\/span><\/strong><span style=\"font-size: 15px;\">\u662f\u4e00\u79cd\u201cfirst-in-class\u201d 5-HT2A\u53d7\u4f53\u62ee\u6297\u5242\uff0c\u540c\u65f6\u4e5f\u662f\u591a\u5df4\u80fa\u53d7\u4f53\u78f7\u86cb\u767d\u8c03\u8282\u5242\uff08DPPM\uff09\u3001\u7a81\u89e6\u524d\u591a\u5df4\u80faD2\u53d7\u4f53\u7684\u90e8\u5206\u6fc0\u52a8\u5242\uff0c\u7a81\u89e6\u540e\u591a\u5df4\u80faD2\u53d7\u4f53\u7684\u62ee\u6297\u5242\u3002\u57fa\u4e8e\u591a\u5df4\u80faD1\u53d7\u4f53\u7684\u6d3b\u6027\u5b83\u8fd8\u53ef\u4ee5\u95f4\u63a5\u8c03\u8282\u8c37\u6c28\u9178\u53d7\u4f53\u6d3b\u6027\uff0c\u540c\u65f6\u5b83\u8fd8\u662f\u8840\u6e05\u7d20\u518d\u6444\u53d6\u6291\u5236\u5242\u3002\u8fd9\u6b3e\u836f\u7269\u80fd\u591f\u5bf9\u8840\u6e05\u7d20\u3001\u591a\u5df4\u80fa\u548c\u8c37\u6c28\u9178\u795e\u7ecf\u9012\u8d28\u901a\u8def\u540c\u65f6\u8fdb\u884c\u8c03\u8282\uff0c\u66fe\u7ecf\u83b7\u5f97FDA\u6388\u4e88\u7684\u5feb\u901f\u901a\u9053\u8d44\u683c\uff0c\u7528\u4e8e\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u3002Lumateperone\u5df2\u7ecf\u5728\u5305\u542b\u8d85\u8fc71900\u540d\u60a3\u8005\u768420\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u63a5\u53d7\u8fc7\u68c0\u9a8c\uff0c\u5305\u62ec\u91c7\u7528\u5229\u57f9\u916e\u4f5c\u4e3a\u9633\u6027\u5bf9\u7167\u7684\u7814\u7a76\u3002\u8be5\u7597\u6cd5\u7684NDA\u5728\u53bb\u5e7412\u6708\u88abFDA\u63a5\u53d7\uff0c\u9884\u8ba1\u5728\u4eca\u5e749\u670827\u65e5\u524d\u83b7\u5f97\u56de\u590d\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/5-1554965987-1.jpeg\" alt=\"\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7814\u7a76\u8fdb\u5c55\" title=\"\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7814\u7a76\u8fdb\u5c55\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\">Lumateperone tosylate<\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\"><\/span><strong><span style=\"font-size: 15px;\">ALKS 3831<\/span><\/strong><span style=\"font-size: 15px;\">\u662fAlkermes\u516c\u53f8\u7814\u53d1\u7684\u4e00\u79cd\u65b0\u578b\u7684\u6bcf\u65e5\u4e00\u6b21\u7684\u53e3\u670d\u975e\u5178\u578b\u6297\u7cbe\u795e\u75c5\u836f\u7269\uff0c\u7531\u65b0\u5206\u5b50\u5b9e\u4f53samidorphan\uff08\u65b0\u578b\u9009\u62e9\u6027\u03bc-\u963f\u7247\u53d7\u4f53\u62ee\u6297\u5242\uff09\u4e0e\u5df2\u4e0a\u5e02\u7684\u6297\u7cbe\u795e\u75c5\u836f\u5965\u6c2e\u5e73\uff08Olanzapine\uff09\u5171\u540c\u7ec4\u6210\u7684\u590d\u65b9\u5236\u5242\u3002\u5965\u6c2e\u5e73\u7684\u526f\u4f5c\u7528\u4e4b\u4e00\u662f\u4f53\u91cd\u589e\u52a0\uff0c\u6709\u4ea7\u751f2\u578b\u7cd6\u5c3f\u75c5\u7684\u98ce\u9669\u3002Alkermes\u5e0c\u671b\u901a\u8fc7\u5965\u6c2e\u5e73\u4e0esamidorphan\u8054\u5408\u4f7f\u7528\uff0c\u7f13\u89e3\u4f53\u91cd\u7684\u589e\u52a0\u3002\u4e00\u9879\u2162\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\uff08ENLIGHTEN-1\uff09\u8be5\u836f\u8868\u73b0\u51fa\u6bd4\u5b89\u6170\u5242\u6cbb\u7597\u7cbe\u795e\u5206\u88c2\u75c7\u66f4\u52a0\u6709\u6548\uff0c\u4f46\u60a3\u8005\u4f53\u91cd\u90fd\u589e\u52a0\u4e86\u3002\u7b2c\u4e8c\u9879\u2162\u671f\u4e34\u5e8a\u7814\u7a76ENLIGHTEN-2\u5bf9561\u4f8b\u7a33\u5b9a\u7684\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u8fdb\u884c\u4e866\u4e2a\u6708\u7684\u8bc4\u4f30\u3002\u7814\u7a76\u4e2d\uff0cALKS 3831\u8fbe\u5230\u4e86\u9884\u5148\u6307\u5b9a\u7684\u590d\u5408\u4e3b\u8981\u7ec8\u70b9\uff0c\u4e0e\u5965\u6c2e\u5e73\u7ec4\u76f8\u6bd4\uff0c6\u4e2a\u6708\u65f6\u590d\u65b9\u836f\u7269\u7ec4\u4f53\u91cd\u589e\u52a0\u7684\u5e73\u5747\u767e\u5206\u6bd4\u66f4\u4f4e\uff08p=0.003\uff09\u3002\u540c\u65f6\uff0c6\u4e2a\u6708\u65f6\u4f53\u91cd\u589e\u52a010 %\u6216\u66f4\u591a\u7684\u60a3\u8005\u6bd4\u4f8b\u4f4e\u4e8e\u5965\u6c2e\u5e73\u7ec4\uff08p=0.003\uff09\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"         style=\"width: 324px;height: 157px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/5-1554965987-2.jpeg\" alt=\"\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7814\u7a76\u8fdb\u5c55\" title=\"\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7814\u7a76\u8fdb\u5c55\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\">ALKS 3831<\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-indent: 2em;\"><strong><span style=\"font-size: 15px;\">Lu AF35700<\/span><\/strong><span style=\"font-size: 15px;\">\u662fLundbeck\u516c\u53f8\u5f00\u53d1\u7684\u9776\u5411\u591a\u5df4\u80fa\u53d7\u4f53\u3001\u8840\u6e05\u7d20\u53d7\u4f53\u548c\u03b1\u80be\u4e0a\u817a\u7d20\u53d7\u4f53\u7684\u62ee\u6297\u5242\u836f\u7269\u3002Lundbeck\u516c\u53f8\u5728\u4e00\u9879\u2162\u671f\u968f\u673a\u53cc\u76f2\u8bd5\u9a8c\uff08DAYBREAK\uff09\u4e2d\u8bc4\u4f30\u4e86\u8be5\u836f\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u5728\u8fd9\u9879\u4e3a\u671f10\u5468\u7684\u8bd5\u9a8c\u4e2d\uff0c\u6709964\u4f4d\u8010\u836f\u6027\u7cbe\u795e\u5206\u88c2\u75c7\uff08TRS\uff09\u60a3\u8005\u63a5\u53d7Lu AF35700\u6216\u5bf9\u7167\u836f\u7269\u6cbb\u7597\u3002\u867d\u7136\u836f\u7269\u663e\u793a\u4e86\u826f\u597d\u7684\u7597\u6548\uff0c\u4f46\u4e34\u5e8a\u672a\u8fbe\u5230\u9996\u8981\u7ec8\u70b9\uff0c\u5373\u4e0e\u4f20\u7edf\u836f\u7269\uff08\u5229\u57f9\u916e\u6216\u5965\u6c2e\u5e73\uff09\u76f8\u6bd4\u6ca1\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u4e0a\u7684\u4f18\u52bf\u3002Lu AF35700\u572810 mg\u548c20 mg\u5242\u91cf\u7684\u8010\u53d7\u6027\u826f\u597d\uff0c\u6ca1\u6709\u672a\u9884\u6599\u5230\u7684\u526f\u4f5c\u7528\u51fa\u73b0\u3002Lundbeck\u6b63\u5728\u5bf9\u6570\u636e\u8fdb\u884c\u8fdb\u4e00\u6b65\u5206\u6790\uff0c\u4ee5\u786e\u5b9a\u8be5\u836f\u7269\u7684\u5f00\u53d1\u662f\u5426\u4f1a\u56e0\u5176\u4ec5\u7528\u4e8e\u6cbb\u7597TRS\u800c\u6682\u505c\u3002TRS\u7684\u4e34\u5e8a\u9700\u6c42\u8fdc\u672a\u6ee1\u8db3\uff0cLu AF35700\u7684\u826f\u597d\u8010\u53d7\u6027\u6216\u6709\u5de8\u5927\u7684\u5e02\u573a\u673a\u4f1a\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><strong><span style=\"font-size: 15px;\">\u8c37\u6c28\u9178\u53d7\u4f53<\/span><\/strong><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u82ef\u73af\u5df1\u54cc\u5576\uff08PCP\uff09\u662f\u4f5c\u7528\u4e8eN-\u7532\u57fa-D-\u5929\u51ac\u6c28\u9178\uff08NMDA\uff09\u53d7\u4f53\u901a\u9053\u4e0a\u7684\u975e\u7ade\u4e89\u62ee\u6297\u5242\uff0c\u4f7f\u5065\u5eb7\u53d7\u8bd5\u8005\u4ea7\u751f\u4e86\u5177\u6709\u5178\u578b\u9633\u6027\u3001\u9634\u6027\u3001\u8ba4\u77e5\u75c7\u72b6\u7684\u7cbe\u795e\u5206\u88c2\u75c7\uff0c\u5728\u6b64\u57fa\u7840\u4e0a\uff0c\u8c37\u6c28\u9178\u529f\u80fd\u7d0a\u4e71\u5047\u8bf4\u5e94\u8fd0\u800c\u751f\u3002\u8c37\u6c28\u9178\u56db\u79cd\u53d7\u4f53\u529f\u80fd\u6c34\u5e73\u7d0a\u4e71\uff0c\u548c\u591a\u5df4\u80fa\u80fd\u7cfb\u7edf\u7684\u76f8\u4e92\u4f5c\u7528\u5f02\u5e38\u6216\u8bb8\u662f\u7cbe\u795e\u75c5\u7684\u53d1\u75c5\u673a\u5236\u4e4b\u4e00\u3002\u6b64\u5916\uff0c\u7518\u6c28\u9178\u8f6c\u8fd0\u86cb\u767d-1 (GlyT-1)\u5728\u5927\u8111\u4e2d\u4e0eNMDA\u53d7\u4f53\u7684\u8868\u8fbe\u6a21\u5f0f\u6709\u5173\uff0c\u901a\u8fc7GlyT-1\u62ee\u6297\u4f5c\u7528\u6291\u5236\u7ec6\u80de\u5916\u7518\u6c28\u9178\u7684\u6444\u53d6\uff0c\u4ece\u800c\u63d0\u9ad8\u7ec6\u80de\u5916\u7518\u6c28\u9178\u7684\u542b\u91cf\uff0c\u53ef\u4ee5\u4fc3\u8fdbNMDA\u53d7\u4f53\u7684\u6d3b\u5316\u3002GlyT-1\u5df2\u88ab\u786e\u5b9a\u4e3a\u6cbb\u7597\u7cbe\u795e\u5206\u88c2\u75c7\u9634\u6027\u75c7\u72b6\u7684\u4e00\u4e2a\u6f5c\u5728\u9776\u70b9\uff0c\u5c3d\u7ba1\u6709\u4e9b\u4e34\u5e8a\u8bc4\u4f30\u7684\u7ed3\u679c\u4ee4\u4eba\u5931\u671b\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><strong><span style=\"font-size: 15px;\">Pomaglumetad methionil<\/span><\/strong><span style=\"font-size: 15px;\">\uff08DB103\uff09<\/span><span style=\"font-size: 15px;\">\u662f\u4ee3\u8c22\u578b\u8c37\u6c28\u9178\u2161\/\u2162\u578b\u53d7\u4f53\uff08mGlu2\/3R\uff09\u6fc0\u52a8\u5242LY404039\u7684\u524d\u836f\u3002\u8be5\u836f\u6700\u521d\u7531\u793c\u6765\u516c\u53f8\u5f00\u53d1\uff0c2015\u5e74\uff0c\u793c\u6765\u5c06DB103\u7684\u5168\u7403\u6743\u76ca\uff0c\u5305\u62ec\u5f00\u53d1\u3001\u751f\u4ea7\u548c\u9500\u552e\u7684\u5168\u90e8\u6743\u5229\uff0c\u8f6c\u8ba9\u7ed9\u7d22\u5143\u751f\u7269\u5168\u8d44\u5b50\u516c\u53f8Denovo Biopharma\u3002DB103\u5728\u5168\u7403\u5df2\u5b8c\u621030\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4f46\u4e34\u5e8a\u521d\u671f\u7814\u7a76\u63d0\u793a\uff0c\u8be5\u836f\u53ef\u80fd\u5bf9\u6cbb\u7597\u7cbe\u795e\u5206\u88c2\u75c7\u6709\u6548\uff0c\u4f46\u4e0d\u5b9c\u4f5c\u4e3a\u6025\u6027\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u5355\u4e00\u6cbb\u7597\u836f\u7269\u30022018\u5e74\uff0c\u7d22\u5143\u751f\u7269\u5ba3\u5e03DB103\u56fd\u9645\u591a\u4e2d\u5fc3\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u83b7\u5f97NMPA\u6279\u51c6\uff0c\u5176\u4e34\u5e8a\u8bd5\u9a8c\u5c06\u5728\u5305\u62ec\u4e2d\u56fd\u5728\u5185\u7684\u591a\u4e2a\u56fd\u5bb6\u540c\u6b65\u5f00\u5c55\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"width: 189px;height: 170px;\"    src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/0-1554965987.jpeg\" alt=\"\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7814\u7a76\u8fdb\u5c55\" title=\"\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7814\u7a76\u8fdb\u5c55\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\">Pomaglumetad methionil<\/span><br  \/><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-indent: 2em;\"><strong><span style=\"font-size: 15px;\">BI-425809<\/span><\/strong><span style=\"font-size: 15px;\">\u662f\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u63a8\u51fa\u7684GlyT1\u6291\u5236\u5242\uff0c\u5df2\u5728\u4e24\u9879\u2160\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5065\u5eb7\u5fd7\u613f\u8005\u4e2d\u9a8c\u8bc1\u4e86\u5176\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u836f\u7269\u52a8\u529b\u5b66\u7279\u5f81\u3002\u8be5\u836f\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u6ca1\u6709\u4e25\u91cd\u526f\u53cd\u5e94\u53d1\u751f\u3002\u76ee\u524d\u8be5\u836f\u9488\u5bf9\u7cbe\u795e\u5206\u88c2\u75c7\u548c\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u7684\u4e34\u5e8a\u2161\u671f\u7814\u7a76\u5728\u8fdb\u884c\u4e2d\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><strong><span style=\"font-size: 15px;\">AVP-786<\/span><\/strong><span style=\"font-size: 15px;\">\u662f\u5927\u51a2\u5236\u836f\u63a8\u51fa\u7684\u6c18\u4ee3\u53f3\u7f8e\u6c99\u82acDeudextromethorphan\uff08\u975e\u7ade\u4e89\u6027NMDA\u53d7\u4f53\u62ee\u6297\u5242\u3001\u03c31\u53d7\u4f53\u6fc0\u52a8\u5242\u30015-\u7f9f\u8272\u80fa\u548c\u53bb\u7532\u80be\u4e0a\u817a\u7d20\u8f6c\u8fd0\u4f53\u6291\u5236\u5242\uff09\u548c\u4f4e\u5242\u91cf\u594e\u5c3c\u4e01\u7ec4\u6210\u7684\u590d\u65b9\u836f\u7269\u3002\u76ee\u524d\u5df2\u5b8c\u6210\u4e86\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u4e34\u5e8a\u2161\u671f\u7814\u7a76\uff0c\u76ee\u7684\u662f\u8bc4\u4f30AVP-786\u4f5c\u4e3a\u6b8b\u4f59\u7cbe\u795e\u5206\u88c2\u75c7\u8f85\u52a9\u6cbb\u7597\u7684\u6709\u6548\u6027\u3001\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002\u9488\u5bf9AD\u8e81\u52a8\u7684\u4e34\u5e8a\u2162\u671f\u7814\u7a76\u548c\u521b\u4f24\u6027\u8111\u635f\u4f24\u3001\u7cbe\u795e\u969c\u788d\u7684\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u5728\u8fdb\u884c\u4e2d\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"width: 337px;height: 172px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/2-1554965987.jpeg\" alt=\"\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7814\u7a76\u8fdb\u5c55\" title=\"\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7814\u7a76\u8fdb\u5c55\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\">AVP-786<\/span><br  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-indent: 2em;\"><strong><span style=\"font-size: 15px;\">CTP-692<\/span><\/strong><span style=\"font-size: 15px;\">\u662f\u6c18\u4ee3D-\u4e1d\u6c28\u9178\uff0c\u662fNMDA\u53d7\u4f53\u7684\u5185\u6e90\u6027\u3001\u5fc5\u9700\u7684\u5171\u6fc0\u52a8\u5242\u3002\u4e00\u9879\u5728\u6fb3\u5927\u5229\u4e9a\u8fdb\u884c\u7684\u4e34\u5e8a\u2160\u671f\u8bd5\u9a8c\u4e2d\uff0c\u8bc4\u4f30\u4e86\u5355\u6b21\u53e3\u670dCTP-692\u4e0eD-\u4e1d\u6c28\u9178\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u836f\u4ee3\u52a8\u529b\u5b66\u3002CTP-692\u6bd4D-\u4e1d\u6c28\u9178\u7684\u8840\u6d46\u66b4\u9732\u589e\u52a0\u3002CTP-692\u8010\u53d7\u6027\u826f\u597d\uff0c\u6ca1\u6709\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u62a5\u544a\u3002\u8be5\u836f\u53e6\u4e00\u9879\u4e34\u5e8a\u8bd5\u9a8c\u8fd8\u5728\u8fdb\u884c\u4e2d\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><strong><span style=\"font-size: 15px;\">BIIB104<\/span><\/strong><span style=\"font-size: 15px;\">\u662f\u8f89\u745e\u539f\u7814\u7684\u03b1-\u6c28\u57fa-3-\u7f9f\u57fa-5-\u7532\u57fa-4-\u5f02\u6076\u5511\u4e19\u9178\uff08AMPA\uff09\u53d7\u4f53\u6b63\u53d8\u6784\u8c03\u8282\u5242\uff0c\u7528\u4e8e\u6cbb\u7597\u4e0e\u7cbe\u795e\u5206\u88c2\u75c7\u76f8\u5173\u7684\u8ba4\u77e5\u969c\u788d\u3002Biogen\u4ee57500\u4e07\u7f8e\u5143\u7684\u9884\u4ed8\u6b3e\u4ee5\u53ca5.15\u4ebf\u7f8e\u5143\u7684\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u91cc\u7a0b\u7891\u5f0f\u4ed8\u6b3e\u6536\u8d2d\u4e86\u8be5\u836f\u7269\u3002\u8fd9\u6b3e\u836f\u7269\u5728\u2160b\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\u5bf9\u8ba4\u77e5\u7684\u5404\u4e2a\u65b9\u9762\u5df2\u8868\u73b0\u51fa\u4e00\u79cd\u53ef\u63a5\u53d7\u7684\u5b89\u5168\u6027\u53ca\u6cbb\u7597\u4f5c\u7528\u8d8b\u52bf\uff0c\u5176\u2161b\u671f\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8ba1\u5212\u542f\u52a8\u4e2d\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"width: 265px;height: 121px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/10-1554965988.jpeg\" alt=\"\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7814\u7a76\u8fdb\u5c55\" title=\"\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7814\u7a76\u8fdb\u5c55\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\">BIIB104<\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"text-indent: 2em;\"><strong><span style=\"font-size: 15px;\">PDE10A\uff08\u78f7\u9178\u4e8c\u916f\u917610A\uff09<\/span><\/strong><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">PDE10A<\/span><span style=\"font-size: 15px;\">\u5728\u5927\u8111\u4e2d\u9ad8\u5ea6\u8868\u8fbe\uff0c\u5305\u62ec\u58f3\u6838\u548c\u5c3e\u795e\u7ecf\uff0c\u5728\u777e\u4e38\u3001\u7532\u72b6\u817a\u3002\u5728\u5927\u8111\u4e2d\uff0cPDE10A\u8c03\u63a7cAMP\/PKA\u548ccGMP\/PKG\u4fe1\u53f7\u7ea7\u8054\uff0c\u4ece\u800c\u589e\u5f3a\u591a\u5df4\u80faD1\u53d7\u4f53\uff0c\u6291\u5236D2\u53d7\u4f53\u4fe1\u53f7\uff0c\u4ee5\u53ca\u6539\u5584\u8c37\u6c28\u9178\u80fd\u795e\u7ecf\u5143\u529f\u80fd\u969c\u788d\u3002\u56e0\u6b64\uff0c\u6291\u5236PDE10A\u88ab\u8ba4\u4e3a\u662f\u6cbb\u7597\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u4e00\u79cd\u65b0\u65b9\u6cd5\u3002\u52a8\u7269\u6a21\u578b\u7684\u521d\u6b65\u7814\u7a76\u652f\u6301\u4e86PDE10A\u6291\u5236\u5242\u5bf9\u7cbe\u795e\u5206\u88c2\u75c7\u9633\u6027\u3001\u9634\u6027\u548c\u8ba4\u77e5\u75c7\u72b6\u7684\u826f\u597d\u4f5c\u7528\u3002\u53e6\u6709\u7814\u7a76\u6307\u51fa\uff0c\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u91cd\u8981\u8111\u533a\u5185\u7684PDE10A\u8f83\u5339\u914d\u5bf9\u7167\u65e0\u663e\u8457\u6539\u53d8\uff0c\u8fd9\u63d0\u793aPDE10A\u901a\u8def\u53ef\u80fd\u53ea\u662f\u4e00\u6761\u4ee3\u507f\u901a\u8def\uff0c\u800c\u975e\u4e3b\u8981\u7684\u75c5\u7406\u5b66\u4ecb\u5bfc\u56e0\u7d20\u3002\u76ee\u524d\u5df2\u6709\u591a\u4e2a\u5019\u9009\u836f\u7269\u8fdb\u5165\u4e34\u5e8a\uff0c\u4f46\u5728\u7814\u7684\u4ec5\u6709\u4e24\u4e2a\uff0c\u5206\u522b\u4e3aLundbeck\u7684Lu AF1116\u548cOmeros\u516c\u53f8\u7684OMS824\uff0c\u5728\u4e34\u5e8a\u2161\u671f\u7814\u7a76\u4e2d\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><strong><span style=\"font-size: 15px;\">Lu AF1116<\/span><\/strong><span style=\"font-size: 15px;\">\u5bf947\u540d\u5065\u5eb7\u53d7\u8bd5\u8005\u5b8c\u6210\u4e86\u2160\u671f\uff08Phase I-15698A\uff09\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8be5\u8bd5\u9a8c\u662f\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u591a\u5242\u91cf\u7814\u7a76\uff0c\u8bc4\u4f30\u4e86\u836f\u7269\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001PK\u548cPD\u7279\u6027\u3002\u2161\u671f\u4e34\u5e8a\u7814\u7a76\u8ba1\u5212\u62db\u52df240\u540d\u60a3\u8005\uff0c\u4e3b\u8981\u76ee\u7684\u662f\u8bc4\u4f30Lu AF1116\u7684\u4e24\u4e2a\u5242\u91cf\u4f5c\u4e3a\u5355\u4e00\u7597\u6cd5\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\u5bf9\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u9634\u6027\u75c7\u72b6\u7684\u7597\u6548\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><strong><span style=\"font-size: 15px;\">OMS824<\/span><\/strong><span style=\"font-size: 15px;\">\u662fOmeros\u516c\u53f8\u5728\u7814\u7684\u6297SZ\u836f\u7269\uff0c\u516c\u53f8\u5728\u4e00\u9879\u2160\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u6d4b\u8bd5\u4e86\u8be5\u836f\u4e0ePDE10\u7684\u7ed3\u5408\u80fd\u529b\uff0cPET\u7ed3\u679c\u663e\u793a\uff0c\u5728\u5065\u5eb7\u53d7\u8bd5\u8005\u7684\u5927\u8111\u57fa\u5e95\u795e\u7ecf\u8282\u4e2d\uff0cPDE10\u7684\u5e73\u5747\u5360\u7528\u7387\u4e3a63 %\uff0c\u4e14\u6ca1\u6709\u5f15\u53d1\u5176\u4ed6PDE10\u6291\u5236\u5242\u6240\u5177\u6709\u7684\u5242\u91cf\u9650\u5236\u526f\u4f5c\u7528\u3002\u4f46\u4e00\u9879\u4e34\u5e8a\u524d\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u5728\u63a5\u53d7OMS824\u6700\u5927\u5242\u91cf\u7814\u7a76\u7684\u51e0\u53ea\u5927\u9f20\u7684\u836f\u7269\u6e38\u79bb\u8840\u6d46\u6d53\u5ea6\u6bd4\u60a3\u8005\u9ad8\u6570\u500d\uff0c\u8fd9\u53ef\u80fd\u5bfc\u81f4\u6301\u7eed\u7684\u591a\u5df4\u80fa\u4fe1\u53f7\u6291\u5236\uff0c\u4ece\u800c\u4ea7\u751f\u6cbb\u7597\u7684\u7d2f\u79ef\u6548\u5e94\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"width: 197px;height: 194px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/9-1554965988.jpeg\" alt=\"\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7814\u7a76\u8fdb\u5c55\" title=\"\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7814\u7a76\u8fdb\u5c55\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\">OMS824<\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-indent: 2em;\"><strong><span style=\"font-size: 15px;\">\u5176\u4ed6<\/span><\/strong><\/p>\n<p style=\"text-indent: 2em;\"><strong><span style=\"font-size: 15px;\">MIN-101<\/span><\/strong><span style=\"font-size: 15px;\">\u662fMinerva Neurosciences\u516c\u53f8\u7814\u53d1\u7684\u65b0\u578b5-HT2A\u53ca\u03c32\u53d7\u4f53\u62ee\u6297\u5242\uff0c\u800c\u5bf9\u591a\u5df4\u80fa\u53d7\u4f53\u3001\u6bd2\u8548\u78b1\u53d7\u4f53\u3001\u80c6\u78b1\u53d7\u4f53\u548c\u7ec4\u80fa\u53d7\u4f53\u6781\u4f4e\u6216\u65e0\u4eb2\u548c\u529b\uff0c\u5bf9\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u7684\u9634\u6027\u75c7\u72b6\u6709\u6f5c\u5728\u6cbb\u7597\u4f5c\u7528\uff0c\u800c\u4e0d\u4f1a\u5f15\u8d77\u591a\u5df4\u80fa\u80fd\u7a81\u89e6\u540e\u963b\u65ad\u6548\u5e94\u3002\u4e3a\u4e86\u7814\u7a76\u8be5\u836f\u7684\u7597\u6548\u3001\u5b89\u5168\u6027\u53ca\u8010\u53d7\u6027\uff0c\u7814\u7a76\u8005\u5f00\u5c55\u4e86\u4e00\u9879\u4e3a\u671f12\u5468\u7684\u968f\u673a\u53cc\u76f2\u5b89\u6170\u5242\u5bf9\u7167\u2161b\u4e34\u5e8a\u7814\u7a76\uff0c\u5171\u7eb3\u5165\u4e86244\u540d\u75c5\u60c5\u5df2\u7a33\u5b9a3\u4e2a\u6708\u53ca\u4ee5\u4e0a\u7684\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\uff0c\u4e2d\u4f4d\u5e74\u9f8441\u5c81\uff0c\u5165\u7ec4\u65f6PANSS\u91cf\u8868\u9634\u6027\u5b50\u91cf\u8868\u5f97\u5206 \u2265 20\u3002\u7ecf\u8fc7\u81f3\u5c115\u5929\u7684\u6d17\u8131\u671f\u540e\uff0c\u53d7\u8bd5\u8005\u88ab\u968f\u673a\u5206\u516532 mg\/d\u300164 mg\/d\u53ca\u5b89\u6170\u5242\u7ec4\uff0c\u6cbb\u759712\u5468\u3002\u7ed3\u679c\u663e\u793a\uff0c\u4e24\u4e2a\u6cbb\u7597\u7ec4\u5747\u53ef\u663e\u8457\u6539\u5584\u9634\u6027\u75c7\u72b6\uff0c\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c32 mg\/d\u7ec4\u548c64 mg\/d\u7ec4\u7684\u60a3\u8005\uff0c\u5176PANSS\u9634\u6027\u56e0\u5b50\u5f97\u5206\u663e\u8457\u964d\u4f4e\uff0c\u6548\u5e94\u5927\u5c0f\u5206\u522b\u4e3a0.45\u548c0.57\u3002\u800c\u9633\u6027\u75c7\u72b6\u76f8\u6bd4\u4e8e\u5b89\u6170\u5242\u65e0\u660e\u663e\u6539\u5584\u3002\u8010\u53d7\u6027\u8f83\u597d\uff0c\u4f53\u91cd\u589e\u52a0\u6216\u5176\u4ed6\u4ee3\u8c22\u5f02\u5e38\u3001\u9547\u9759\u548c\u9525\u4f53\u5916\u75c7\u72b6\u5bf9\u6bd4\u5b89\u6170\u5242\u7ec4\u6ca1\u6709\u663e\u8457\u6539\u53d8\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/8-1554965988.jpeg\" alt=\"\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7814\u7a76\u8fdb\u5c55\" title=\"\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7814\u7a76\u8fdb\u5c55\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\">MIN-101<\/span><br  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-indent: 2em;\"><strong><span style=\"font-size: 15px;\">Basmisanil<\/span><\/strong><span style=\"font-size: 15px;\">\u662f\u7f57\u6c0f\u7814\u53d1\u7684GABAA\u53d7\u4f53\u03b15\uff08GABRA5\uff09\u4e9a\u5355\u4f4d\u8d1f\u53d8\u6784\u8c03\u8282\u5242\uff0c\u8be5\u7c7b\u53d7\u4f53\u5206\u5e03\u5728\u4e0e\u8ba4\u77e5\u5904\u7406\u76f8\u5173\u7684\u79bb\u6563\u5927\u8111\u533a\u57df\u3002Basmisanil\u4f5c\u4e3a\u8f85\u52a9\u836f\u7269\u4e0e\u6297\u7cbe\u795e\u75c5\u836f\u7269\u7528\u4e8e\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7684\u4e00\u9879\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u53cc\u76f2\u3001\u5e73\u884c\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7684\u4e34\u5e8a\u2161b\u671f\u7814\u7a76\u6b63\u5728\u62db\u52df\u4e2d\u3002\u800c\u6b64\u524d\u8be5\u836f\u66fe\u5bf9AD\u548c\u5510\u6c0f\u7efc\u5408\u5f81\u60a3\u8005\u7684\u8ba4\u77e5\u969c\u788d\u505a\u8fc7\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4f46\u5747\u5df2\u6682\u505c\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/9-1554965988-1.jpeg\" alt=\"\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7814\u7a76\u8fdb\u5c55\" title=\"\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7814\u7a76\u8fdb\u5c55\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\">Basmisanil<\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-indent: 2em;\"><strong><span style=\"font-size: 15px;\">AVN 211<\/span><\/strong><span style=\"font-size: 15px;\">\u662fAvineuro\u5236\u53d1\u7684\u65b0\u578b\u9ad8\u9009\u62e9\u60275-HT6\u53d7\u4f53\u62ee\u6297\u5242\uff0c\u7528\u4e8e\u6539\u5584\u7cbe\u795e\u5206\u88c2\u75c7\u60a3\u8005\u7684\u8ba4\u77e5\u80fd\u529b\u3002\u4e00\u9879\u53cc\u76f2\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5728\u8fd150\u540d\u975e\u5178\u578b\u6297\u7cbe\u795e\u75c5\u836f\u7269\u6cbb\u7597\u7a33\u5b9a\u7684\u60a3\u8005\u4e2d\u8fdb\u884c\uff0c\u7ed3\u679c\u663e\u793a\uff0cAVN 211\u589e\u52a0\u4e86\u6297\u7cbe\u795e\u75c5\u836f\u7269\u7597\u6548\u5e76\u5bf9\u8ba4\u77e5\uff08\u6ce8\u610f\u529b\uff09\u6709\u4e00\u5b9a\u4f5c\u7528\uff0c\u4e14\u8010\u53d7\u6027\u826f\u597d\u3002<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/2-1554965988.jpeg\" alt=\"\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7814\u7a76\u8fdb\u5c55\" title=\"\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7814\u7a76\u8fdb\u5c55\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\">AVN 211<br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\">\u88681\uff1a\u4e34\u5e8a\u5728\u7814\u7684\u6297\u7cbe\u795e\u5206\u88c2\u75c7\u836f\u7269<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"rich_pages\"          style=\"width: 100%;height: auto;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/1-1554965989.jpeg\" alt=\"\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7814\u7a76\u8fdb\u5c55\" title=\"\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7814\u7a76\u8fdb\u5c55\"  \/><img class=\"rich_pages\"       style=\"line-height: 1.6;width: 100%;height: auto;\"    src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/3-1554965989.jpeg\" alt=\"\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7814\u7a76\u8fdb\u5c55\" title=\"\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7814\u7a76\u8fdb\u5c55\"  \/><\/p>\n<section class=\"_editor\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<p style=\"text-align: center;width:2em;margin-left:auto;margin-right:auto;\"><img   class=\"\"   src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/9-1554965990.png\" alt=\"\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7814\u7a76\u8fdb\u5c55\" title=\"\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u7814\u7a76\u8fdb\u5c55\"  \/><\/p>\n<section style=\"text-align: center;\">\n<section style=\"margin-top: -20px;border-style: solid;border-width: 1px;border-color: #24b37a;padding: 2px;display: inline-block;box-sizing: border-box;\">\n<section style=\"border-style: dotted;border-width: 1px;border-color: #24b37a;padding: 2px 10px;display: inline-block;box-sizing: border-box;\">\n<p style=\"letter-spacing: 2px;\">\u7ed3\u8bed<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u867d\u7136\u8fd1\u5e74\u6765\u7cbe\u795e\u5206\u88c2\u75c7\u6cbb\u7597\u53d6\u5f97\u4e86\u91cd\u5927\u8fdb\u5c55\uff0c\u4f46\u4e0e\u764c\u75c7\u7b49\u5176\u4ed6\u6cbb\u7597\u9886\u57df\u76f8\u6bd4\uff0c\u7cbe\u795e\u5206\u88c2\u75c7\u65b0\u836f\u7684\u7814\u7a76\u8fdb\u5c55\u8981\u6162\u5f97\u591a\u3002\u57fa\u4e8e\u75c5\u56e0\u3001\u795e\u7ecf\u751f\u7269\u5b66\u548c\u75c5\u7406\u5b66\u800c\u975e\u75c7\u72b6\u548c\u4f53\u5f81\u7684\u8bca\u65ad\u65b0\u5de5\u5177\u7684\u5f00\u53d1\u3001\u795e\u7ecf\u53ef\u5851\u6027\u5728\u7cbe\u795e\u75c7\u72b6\u51fa\u73b0\u548c\u53d1\u5c55\u4e2d\u4f5c\u7528\u7684\u6df1\u5165\u4e86\u89e3\u3001\u80fd\u9a8c\u8bc1\u65b0\u9776\u70b9\u548c\u836f\u7269\u7597\u6548\u7684\u52a8\u7269\u6a21\u578b\u7684\u5efa\u7acb\u662f\u76ee\u524d\u9700\u8981\u514b\u670d\u7684\u91cd\u8981\u969c\u788d\u3002\u8054\u5408\u7528\u836f\u3001\u957f\u6548\u5242\u578b\u53ca\u65b0\u673a\u5236\u65b0\u9776\u70b9\u836f\u7269\u662f\u65b0\u7a76\u7684\u4e3b\u8981\u65b9\u5411\u3002\u9488\u5bf9\u7cbe\u795e\u5206\u88c2\u75c7\u9634\u6027\u75c7\u72b6\u548c\u8ba4\u77e5\u75c7\u72b6\u7684\u836f\u7269\u5df2\u6709\u591a\u4e2a\u5728\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u8fd9\u4e9b\u8fdb\u5c55\u5c06\u7ed9\u60a3\u8005\u7684\u6cbb\u7597\u5e26\u6765\u65b0\u7684\u5e0c\u671b\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-indent: 0em;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/p>\n<p style=\"text-indent: 0em;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">1\u3001Flint J., Munaf\u00f2 M. Schizophrenia: Genesis of a complex disease. Nature, 2014, 511, 412\u2013413.<\/span><\/p>\n<p style=\"text-indent: 0em;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">2\u3001Chen J. C., Cao F., Liu L. F. et al. Genetic studies of schizophrenia: an update. Neurosci Bull, 2015, 31(1): 87-98.<\/span><\/p>\n<p style=\"text-indent: 0em;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">3\u3001Marques T. R., Natesan S., Niccolini F., et al. Phosphodiesterase 10A in Schizophrenia: A PET Study Using [11C]IMA107. Am J Psychiatry. 2016, 173 (7): &nbsp;714-721.<\/span><\/p>\n<p style=\"text-indent: 0em;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">4\u30012019\u5e74\uff0c\u8fd920\u6b3e\u65b0\u836f\u6709\u671b\u83b7\u6279\u4e0a\u5e02. https:\/\/mp.weixin.qq.com\/s\/YZ0ypnE1PqXL94fVloxRNw.<\/span><\/p>\n<p style=\"text-indent: 0em;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">5\u3001Informa\u6570\u636e\u5e93\uff0c\u68c0\u7d22\u65e5\u671f\uff1a2019-3-19.<\/span><\/p>\n<p style=\"text-indent: 0em;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">6\u3001IMS Health Analytics Link\u6570\u636e\u5e93\uff0c\u68c0\u7d22\u65e5\u671f\uff1a2019\u5e743\u670819\u65e5.<\/span><\/p>\n<p style=\"text-indent: 0em;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">7\u3001Clarivate Analytics Integrity\u6570\u636e\u5e93\uff0c\u68c0\u7d22\u65e5\u671f\uff1a2019\u5e743\u670819\u65e5.<\/span><\/p>\n<p style=\"text-indent: 0em;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">8\u3001\u6570\u636e\u5e93\uff0c\u68c0\u7d22\u65e5\u671f\uff1a2019-3-19.<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u7cbe\u795e\u5206\u88c2\u75c7\uff08schizophrenia\uff0cSZ\uff09\u662f\u4e00\u7ec4\u75c5\u56e0\u672a\u660e\u7684\u91cd\u6027\u7cbe\u795e\u75c5\uff0c\u591a\u5728\u9752\u58ee\u5e74\u65f6\u671f\u7f13\u6162\u6216\u4e9a\u6025\u6027\u8d77\u75c5\uff0c\u4e34\u5e8a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":82313,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/82312"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=82312"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/82312\/revisions"}],"predecessor-version":[{"id":82328,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/82312\/revisions\/82328"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/82313"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=82312"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=82312"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=82312"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}