{"id":82337,"date":"2019-03-22T00:00:50","date_gmt":"2019-04-11T06:59:58","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/82337\/"},"modified":"2019-04-11T14:59:59","modified_gmt":"2019-04-11T06:59:59","slug":"77aac9a7f7","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/82337\/","title":{"rendered":"\u997f\u6b7b\u764c\u7ec6\u80de\u3001\u4e8c\u7532\u53cc\u80cd\u3001\u81ea\u566c\u6291\u5236\u5242\u2026\u2026|3\u6708\u5341\u5927\u6297\u764c\u7a81\u7834\uff08\u4e0a\uff09"},"content":{"rendered":"
\n
\n
\u8f6c\u81ea\u533b\u836f\u9b54\u65b9<\/span>
<\/section>\n<\/section>\n

\u6742\u5fd7\uff1a<\/span><\/strong>Nature\u3001PNAS\u7b49<\/span><\/span><\/p>\n

\u4eae\u70b9\uff1a<\/span><\/strong><\/span><\/p>\n

1\uff09\u5bf9\u6297\u4e09\u9634\u6027\u4e73\u817a\u764c\uff0c\u4e8c\u7532\u53cc\u80cd\u8054\u5408\u6cbb\u7597\u4ee4\u4eba\u671f\u5f85<\/span><\/p>\n

2\uff09\u764c\u75c7\u6269\u6563\u4e3a\u4f55\u201c\u504f\u7231\u201d\u809d\u810f\u8c1c\u9898\u88ab\u7834\u89e3<\/span><\/p>\n

3\uff09\u540c\u65e52\u7bc7Nature Medicine \u62a5\u9053\u80f0\u817a\u764c\u81ea\u566c\u6291\u5236\u7597\u6cd5<\/span><\/p>\n

4\uff09\u9664\u4e86CD47\uff0c\u74e6\u89e3\u764c\u7ec6\u80de\u201c\u522b\u5403\u6211\u201d\u4fe1\u53f7\u6709\u4e86\u65b0\u9776\u70b9<\/span><\/p>\n

5\uff09\u5375\u5de2\u764c\u65b0\u836f\u201c\u5b9e\u529b\u4e0d\u51e1\u201d<\/span><\/strong><\/span><\/p>\n


<\/p>\n

\n
\n
\n
\n
\n
\n
\n
\n
\n
\n

1<\/p>\n<\/section>\n<\/section>\n

\n

Nature\u533b\u5b66\uff1a\u80f0\u817a\u764c\u6cbb\u7597\u65b0\u601d\u8def\u2014\u2014\u81ea\u566c\u6291\u5236\u8054\u5408\u7597\u6cd5<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u5728\u764c\u75c7\u4e2d\uff0c\u80f0\u817a\u764c<\/strong>\u5c24\u4e3a\u201c\u53ef\u6015\u201d\uff0c\u4e00\u5e74\u751f\u5b58\u7387\u6781\u4f4e\uff0c\u6cbb\u7597\u8fdb\u5c55\u843d\u540e\u4e8e\u8bb8\u591a\u5176\u5b83\u6076\u6027\u80bf\u7624\u3002\u8fd1\u5e74\u6765\uff0c\u5bfb\u627e\u5207\u65ad\u80fd\u91cf\u6765\u6e90\u7684\u65b9\u6cd5\u662f\u80f0\u817a\u764c\u7814\u7a76\u7684\u4e3b\u8981\u65b9\u5411\u4e4b\u4e00\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u81ea\u566c<\/span><\/strong>\u662f\u764c\u7ec6\u80de\u5faa\u73af\u5229\u7528\u7269\u8d28\u4f5c\u4e3a\u8425\u517b\u6765\u6e90\u7684\u8fc7\u7a0b\u3002\u5148\u524d\uff0c\u79d1\u5b66\u5bb6\u4eec\u5df2\u7ecf\u53d1\u73b0\uff0c\u5728\u643a\u5e26KRAS\u7a81\u53d8\u7684\u80f0\u817a\u764c\u4e2d\uff0c\u81ea\u566c\u4f5c\u7528\u4f1a\u589e\u52a0\u3002\u57fa\u4e8e\u8fd9\u4e00\u53d1\u73b0\uff0c\u4e00\u79cd\u80fd\u591f\u76f4\u63a5\u963b\u65ad\u81ea\u566c\u4f5c\u7528\u7684\u5316\u5408\u7269\u2014\u2014hydroxychloroquine\u5df2\u7ecf\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8fdb\u884c\u6d4b\u8bd5\u3002\u4e0d\u8fc7\uff0c\u5355\u72ec\u4f7f\u7528\u8be5\u836f\u6297\u764c\u7597\u6548\u6709\u9650<\/strong>\uff0c\u8fd9\u53ef\u80fd\u662f\u56e0\u4e3a\uff0c\u764c\u7ec6\u80de\u53ef\u4ee5\u9002\u5e94\u5176\u5b83\u7684\u80fd\u91cf\u9014\u5f84\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u90a3\u4e48\uff0c\u5982\u4f55\u8ba9\u81ea\u566c\u6291\u5236\u5242\u66f4\u6709\u6548\u5462\uff1f<\/strong>3\u67084\u65e5\uff0c\u53d1\u8868\u5728Nature Medicine\u4e0a\u7684\u4e00\u9879\u7814\u7a76\u4e2d[1]\uff0c\u5317\u5361\u7f57\u83b1\u7eb3\u5927\u5b66\u6559\u5802\u5c71\u5206\u6821\u7684\u79d1\u5b66\u5bb6\u4eec\u53d1\u73b0\uff0c\u963b\u65adKRAS\u57fa\u56e0\u5b9e\u9645\u4e0a\u589e\u52a0\u4e86\u764c\u7ec6\u80de\u5bf9\u81ea\u566c\u7684\u4f9d\u8d56\u3002<\/strong>\u5f53\u4ed6\u4eec\u7528\u963b\u65adKRAS\u57fa\u56e0\u4e0b\u6e38\u4fe1\u53f7\u7684\u5316\u5408\u7269\u7ed3\u5408<\/strong>\u76f4\u63a5\u963b\u65ad\u81ea\u566c\u7684\u5316\u5408\u7269\u65f6\uff0c\u8fd9\u79cd\u8054\u5408\u6cbb\u7597\u7684\u7597\u6548\u4f18\u4e8e\u4e24\u79cd\u5316\u5408\u7269\u7684\u5355\u72ec\u7528\u836f\u3002<\/strong><\/span><\/p>\n

 <\/span><\/p>\n

\u4e4b\u6240\u4ee5\u4ea7\u751f\u534f\u540c\u4f5c\u7528\uff0c\u662f\u56e0\u4e3a\uff0c\u963b\u65adKRAS\u4e0b\u6e38\u7684\u4fe1\u53f7\u4f3c\u4e4e\u4f1a\u635f\u5bb3\u5176\u5b83\u80fd\u91cf\u751f\u4ea7\u8fc7\u7a0b\uff0c\u6bd4\u5982\u7cd6\u9175\u89e3<\/strong>\uff0c\u4ece\u800c\u8feb\u4f7f\u764c\u7ec6\u80de\u4f9d\u8d56\u4e8e\u81ea\u566c\u6216\u4e0e\u81ea\u566c\u76f8\u5173\u7684\u201c\u81ea\u98df\u201d\uff08<\/span> self-eating\uff09<\/span>\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u63a5\u4e0b\u6765\uff0c\u79d1\u5b66\u5bb6\u4eec\u5e0c\u671b\u5f00\u5c55\u4e34\u5e8a\u7814\u7a76\uff0c\u4ee5\u786e\u5b9a\u8fd9\u79cd\u7597\u6cd5\u7684\u7597\u6548\u548c\u60a3\u8005\u8010\u53d7\u6027\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u540c\u65e5\u53d1\u8868\u5728Nature Medicine\u7684\u53e6\u4e00\u7bc7\u8bba\u6587\u4e5f\u83b7\u5f97\u4e86\u7c7b\u4f3c\u7684\u53d1\u73b0[2]\u3002<\/span><\/p>\n


<\/span><\/p>\n

\n
\n
\n
\n
\n
\n
\n
\n
\n
\n

2<\/p>\n<\/section>\n<\/section>\n

\n

Nature\u533b\u5b66\uff1a\u74e6\u89e3\u764c\u7ec6\u80de\u201c\u522b\u5403\u6211\u201d\u4fe1\u53f7\u7684\u65b0\u9776\u70b9<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/span><\/p>\n

CD47\u662f\u5e7f\u6cdb\u8868\u8fbe\u5728\u6b63\u5e38\u7ec6\u80de\u8868\u9762\u7684\u4e00\u79cd\u86cb\u767d\u8d28\uff0c\u901a\u8fc7\u4e0e\u5de8\u566c\u7ec6\u80de\u8868\u9762\u7684SIRP\u03b1\u7ed3\u5408\uff0c\u91ca\u653e\u4e00\u79cd\u201c\u522b\u5403\u6211\u201d\u7684\u4fe1\u53f7\uff0c\u4ece\u800c\u4fdd\u62a4\u5065\u5eb7\u7ec6\u80de\u4e0d\u88ab\u5de8\u566c\u7ec6\u80de\u201c\u5403\u6389\u201d\u3002\u4e0d\u5e78\u7684\u662f\uff0c\u764c\u7ec6\u80de\u4e5f\u5b66\u4f1a\u4e86\u8fd9\u4e00\u673a\u5236\uff1a\u5728\u8868\u9762\u8fc7\u91cf\u8868\u8fbeCD47\uff0c\u4f7f\u5de8\u566c\u7ec6\u80de\u628a\u5b83\u4eec\u5f53\u4f5c\u201c\u6b63\u5e38\u7ec6\u80de\u201d\uff0c\u4ece\u800c\u8eb2\u907f\u4e86\u88ab\u201c\u5403\u6389\u201d\u7684\u547d\u8fd0\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u76ee\u524d\u9776\u5411CD47\u53ca\u5176\u914d\u4f53SIRP\u03b1 \u7684\u4e00\u4e9b\u7597\u6cd5\u5df2\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\uff0c\u4f46\u8fd9\u7c7b\u836f\u7269\u7684\u4e00\u4e9b\u526f\u4f5c\u7528\uff08\u5982\uff0c\u8d2b\u8840\u3001\u7ea2\u7ec6\u80de\u51cf\u5c11\uff09\u8ba9\u4eba\u62c5\u5fc3\u3002<\/span><\/p>\n

 <\/span><\/p>\n

3\u67084\u65e5\uff0c\u53d1\u8868\u5728Nature Medicine\u4e0a\u7684\u4e00\u7bc7\u8bba\u6587\u4e2d[3]\uff0c\u6765\u81ea\u8377\u5170\u7684\u79d1\u5b66\u5bb6\u63cf\u8ff0\u4e86\u4e00\u79cd\u963b\u65adCD47\u7684\u65b0\u65b9\u6cd5\u3002<\/strong>\u7814\u7a76\u53d1\u73b0\uff0c\u4e00\u79cd\u540d\u4e3aQPCTL\u7684\u9176<\/strong>\u662f\u5f62\u6210\u201c\u522b\u5403\u6211\u201d\u4fe1\u53f7\u7684\u5173\u952e\u86cb\u767d\u3002QPCTL\u6539\u53d8\u4e86CD47\u86cb\u767d\u7684\u7ed3\u6784\uff0c\u5728\u6ca1\u6709QPCTL\u6d3b\u6027\u7684\u60c5\u51b5\u4e0b\uff0cCD47\u5206\u5b50\u4e0d\u518d\u80fd\u591f\u53d1\u51fa\u6291\u5236\u4fe1\u53f7\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u8be5\u7814\u7a76\u7684\u9886\u5bfc\u8005Ton Schumacher\u8868\u793a\uff0c\u8fd9\u662f\u975e\u5e38\u91cd\u8981\u7684\u4e00\u4e2a\u53d1\u73b0\uff0c\u56e0\u4e3a\u4ee5QPCTL\u4f5c\u4e3a\u9776\u70b9\u53ef\u80fd\u6bd4\u76f4\u63a5\u6291\u5236CD47\u66f4\u6709\u4f18\u52bf<\/strong>\u3002\u56e2\u961f\u9884\u8ba1\uff0cQPCTL\u6291\u5236\u5242\u5c06\u5728\u672a\u6765\u51e0\u5e74\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\n
\n
\n
\n
\n
\n
\n
\n
\n
\n

3<\/p>\n<\/section>\n<\/section>\n

\n

\u5b50\u520a\uff1a\u663e\u8457\u63d0\u9ad8\u751f\u5b58\u7387\uff0c\u8fd9\u6b3e\u5375\u5de2\u764c\u65b0\u836f\u201c\u5b9e\u529b\u4e0d\u51e1\u201d<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u5375\u5de2\u764c<\/span><\/strong>\u4e0d\u662f\u6700\u5e38\u89c1\u7684\u764c\u75c7\uff0c\u4f46\u5374\u662f\u6700\u81f4\u547d\u7684\u764c\u75c7\u4e4b\u4e00\u3002\u8fd9\u662f\u56e0\u4e3a\u5927\u7ea670%\u7684\u75c5\u4f8b\u4f1a\u590d\u53d1\u30023\u67085\u65e5\uff0c\u53d1\u8868\u5728 Reports\u4e0a\u7684\u4e00\u7bc7\u8bba\u6587\u4e2d[4]\uff0c\u6765\u81ea\u5339\u5179\u5821\u5927\u5b66\u7b49\u673a\u6784\u7684\u79d1\u5b66\u5bb6\u4eec\u62a5\u544a\u4e86\u4e00\u79cd\u7784\u51c6\u5375\u5de2\u764c\u590d\u53d1\u6839\u6e90\u2014\u2014\u5e72<\/strong>\u7ec6\u80de\u6837\u5375\u5de2\u764c\u7ec6\u80de<\/strong>\uff08stem-like ovarian cancer cells\uff09\u7684\u65b0\u836f\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u8fd9\u4e00\u4ee3\u53f7\u4e3a673A<\/strong>\u7684\u5b9e\u9a8c\u6027\u65b0\u836f\u80fd\u591f\u7279\u5f02\u6027\u5730\u6740\u6b7b\u5316\u7597\u540e\u503e\u5411\u4e8e\u5b58\u6d3b\u7684\u6837\u7ec6\u80de\u3002\u5728\u5375\u5de2\u764c\u5c0f\u9f20\u6a21\u578b\u4e2d\uff0c\u8054\u5408673A\u6cbb\u7597\u548c\u5316\u7597\u53ef\u663e\u8457\u63d0\u9ad8\u751f\u5b58\u7387\u3002<\/strong><\/span><\/p>\n

 <\/span><\/p>\n

\u636e\u7814\u7a76\u4eba\u5458\u4ecb\u7ecd\uff0c\u5f62\u6210\u4e00\u4e2a\u80bf\u7624\u53ea\u9700\u898111\u4e2a\u6837\u764c\u7ec6\u80de\u3002673A\u9776\u5411\u7684\u662fALDH\u901a\u8def<\/strong>\u3002\u764c\u7ec6\u80de\u4f9d\u8d56\u8fd9\u4e00\u901a\u8def\u6765\u6e05\u9664\u5b83\u4eec\u5feb\u901f\u589e\u6b96\u4ea7\u751f\u7684\u6bd2\u7d20\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u5c3d\u7ba1673A\u53ea\u80fd\u6740\u6b7b\u7ea63%\u52305%\u7684\u7ec6\u80de\uff0c\u4f46\u7531\u4e8e\u88ab\u6740\u6b7b\u7684\u662f\u6837\u7ec6\u80de\uff0c\u56e0\u6b64\uff0c\u6297\u764c\u529f\u6548\u663e\u8457\u3002\u5728\u6ce8\u5c04\u4e86\u4eba\u7c7b\u5375\u5de2\u764c\u7ec6\u80de\u7684\u5c0f\u9f20\u4e2d\uff0c\u63a5\u53d7\u5316\u7597+673A\u8054\u5408\u6cbb\u7597\u7684\u5c0f\u9f20\u670960%\u57286\u4e2a\u6708\u540e\u201c\u65e0\u764c\u201d\u4e86<\/strong>\uff0c\u800c\u4ec5\u63a5\u53d7\u5316\u7597\u6cbb\u7597\u7684\u5c0f\u9f20\uff0c\u5bf9\u5e94\u7684\u6bd4\u4f8b\u4e3a10%\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u66f4\u4ee4\u4eba\u9707\u60ca\u7684\u662f\uff0c673A\u5bf9\u5316\u7597\u8010\u836f\u80bf\u7624\u540c\u6837\u6709\u6548<\/strong>\u3002\u5f53\u88ab\u6ce8\u5c04\u4e86\u201c\u987d\u56fa\u764c\u7ec6\u80de\u201d\u7684\u5c0f\u9f20\u63a5\u53d7\u8054\u5408\u6cbb\u75976\u4e2a\u6708\u540e\uff0c\u8fd1\u4e09\u5206\u4e4b\u4e8c\u7684\u5c0f\u9f20\u75c5\u60c5\u5f97\u5230\u7f13\u89e3\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u4ec5\u63a5\u53d7\u5316\u7597\u7684\u5c0f\u9f20\u57286\u4e2a\u6708\u540e\u5df2\u5168\u90e8\u6b7b\u4ea1\u3002\u6b64\u5916\uff0c673A\u5bf9\u5c0f\u9f20\u5b8c\u5168\u6ca1\u6709\u6bd2\u6027\u3002<\/strong><\/span><\/p>\n

 <\/span><\/p>\n

\u79d1\u5b66\u5bb6\u4eec\u6307\u51fa\uff0c673A\u5728\u6740\u6b7b\u6837\u7ec6\u80de\u65b9\u9762\u7684\u6548\u679c\u662f\u5148\u524d\u7684ALDH\u6291\u5236\u5242\u768410\u500d<\/strong>\u3002\u7136\u800c\uff0c\u5c3d\u7ba1\u6210\u679c\u4ee4\u4eba\u632f\u594b\uff0c\u4f46\u672a\u6765\u8fd8\u6709\u5f88\u591a\u5de5\u4f5c\u9700\u8981\u8fdb\u884c\uff0c\u5176\u4e2d\u5305\u62ec\uff0c\u63d0\u9ad8673A\u7684\u6eb6\u89e3\u5ea6<\/strong>\uff0c\u4f7f\u5176\u5728\u4f53\u5185\u53d1\u6325\u66f4\u957f\u65f6\u95f4\u7684\u4f5c\u7528\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\n
\n
\n
\n
\n
\n
\n
\n
\n
\n

4<\/p>\n<\/section>\n<\/section>\n

\n

Nature\uff1a\u5bf9\u6297\u4e09\u9634\u6027\u4e73\u817a\u764c\uff0c\u4e8c\u7532\u53cc\u80cd\u8054\u5408\u6cbb\u7597\u4ee4\u4eba\u671f\u5f85<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

3\u67086\u65e5\uff0c\u53d1\u8868\u5728Nature\u4e0a\u7684\u4e00\u7bc7\u8bba\u6587\u4e2d[5]\uff0c\u6765\u81ea\u7f8e\u56fd\u829d\u52a0\u54e5\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u4eec\u8bc1\u5b9e\uff0c\u5c0f\u9f20\u7814\u7a76\u8868\u660e\uff0c\u4e8c\u7532\u53cc\u80cd<\/strong>\u8054\u5408\u53e6\u4e00\u6b3e\u5df2\u4e0a\u5e02\u7684\u8001\u836f\u8840\u7ea2\u7d20<\/strong>\u6709\u671b\u7528\u4e8e\u6cbb\u7597\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08TNBC\uff09\u3002<\/span><\/p>\n

 <\/span><\/p>\n

BACH1\u662f\u4e00\u79cd\u8f6c\u5f55\u56e0\u5b50\uff0c\u901a\u5e38\u5728TNBC\u4e2d\u9ad8\u5ea6\u8868\u8fbe\uff0c\u662f\u764c\u75c7\u53d1\u751f\u8f6c\u79fb\u6240\u9700\u8981\u7684\u4e00\u79cd\u86cb\u767d\u8d28\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u5f53\u79d1\u5b66\u5bb6\u4eec\u7528\u8840\u7ea2\u7d20\u5904\u7406\u764c\u7ec6\u80de\u65f6\uff0cBACH1\u7684\u6c34\u5e73\u964d\u4f4e\u4e86\uff0c\u4ece\u800c\u4f7f\u5f97\u7f3a\u5931BACH1\u7684\u764c\u7ec6\u80de\u6539\u53d8\u4e86\u4ee3\u8c22\u9014\u5f84\u3002\u800c\u57fa\u4e8e\u4e4b\u524d\u7684\u7814\u7a76\uff0c\u7814\u7a76\u4eba\u5458\u63a8\u6d4b\uff0c\u4ee3\u8c22\u9014\u5f84\u88ab\u6539\u53d8\u7684\u764c\u7ec6\u80de\u5f88\u5bb9\u6613\u88ab\u4e8c\u7532\u53cc\u80cd\u6291\u5236\u7ebf\u7c92\u4f53\u547c\u5438\u3002\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u7ed3\u679c\u8bc1\u5b9e\uff0c\u5728\u5c0f\u9f20\u80bf\u7624\u6a21\u578b\u4e2d\uff0c\u8840\u7ea2\u7d20\u548c\u4e8c\u7532\u53cc\u80cd\u8fd9\u79cd\u65b0\u578b\u7ec4\u5408\u80fd\u591f\u6291\u5236\u80bf\u7624\u751f\u957f\u3002<\/strong><\/span><\/p>\n

 <\/span><\/p>\n

\u4f5c\u8005\u4eec\u8ba4\u4e3a\uff0c\u8fd9\u4e9b\u53d1\u73b0\u53ef\u80fd\u4f1a\u6269\u5c55\u5230\u4e73\u817a\u764c\u4e4b\u5916\u3002\u56e0\u4e3a\uff0cBACH1\u4e0d\u4ec5\u53ea\u5728TNBC\u4e2d\u9ad8\u8868\u8fbe<\/strong>\uff0c\u5728\u5305\u62ec\u80ba\u764c\u3001\u80be\u764c\u3001\u5b50\u5bab\u764c\u3001\u524d\u5217\u817a\u764c\u548c\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u5728\u5185\u7684\u8bb8\u591a\u764c\u75c7\u4e2d\u90fd\u6709\u8868\u8fbe\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\n
\n
\n
\n
\n
\n
\n
\n
\n
\n

5<\/p>\n<\/section>\n<\/section>\n

\n

Nature\uff1a\u4e3a\u4f55\u764c\u75c7\u6269\u6563\uff0c\u201c\u504f\u7231\u201d\u809d\u810f\uff1f<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u5f53\u764c\u75c7\u6269\u6563\u5230\u53e6\u4e00\u4e2a\u5668\u5b98\u65f6\uff0c\u5b83\u901a\u5e38\u4f1a\u9009\u62e9\u809d\u810f<\/strong>\uff0c\u8fd9\u662f\u4e3a\u4ec0\u4e48\u5462\uff1f3\u67086\u65e5\uff0c\u53d1\u8868\u5728Nature\u4e0a\u7684\u4e00\u7bc7\u8bba\u6587\u4e2d[6]\uff0c\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u4eec\u89e3\u91ca\u4e86\u539f\u56e0\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u7814\u7a76\u53d1\u73b0\uff0c\u809d\u7ec6\u80de\u5904\u4e8e\u4e00\u79cd\u8fde\u9501\u53cd\u5e94\u7684\u4e2d\u5fc3\uff0c\u8fd9\u4f7f\u5f97\u5b83\u4eec\u7279\u522b\u5bb9\u6613\u53d7\u5230\u764c\u7ec6\u80de\u7684\u5f71\u54cd\u3002<\/strong>\u8fd9\u4e9b\u809d\u7ec6\u80de\u901a\u8fc7\u6fc0\u6d3b\u4e00\u79cd\u540d\u4e3aSTAT3<\/strong>\u7684\u86cb\u767d\u8d28\u6765\u54cd\u5e94\u708e\u75c7\uff0c\u800cSTAT3\u53cd\u8fc7\u6765\u53c8\u589e\u52a0\u4e86\u540d\u4e3aSAA<\/strong>\u7684\u86cb\u767d\u8d28\u7684\u8868\u8fbe\uff0c\u8fdb\u800c\u91cd\u5851\u4e86\u809d\u810f\u73af\u5883\uff0c\u4e3a\u764c\u7ec6\u80de\u201c\u64ad\u79cd\u201d\u521b\u9020\u4e86\u201c\u571f\u58e4\u201d\u3002<\/strong><\/span><\/p>\n

 <\/span><\/p>\n

\u57fa\u4e8e\u8fd9\u4e9b\u53d1\u73b0\uff0c\u79d1\u5b66\u5bb6\u4eec\u8fdb\u4e00\u6b65\u8bc1\u5b9e\uff0c\u5728\u5c0f\u9f20\u4e2d\uff0c\u4ec5\u5220\u9664\u809d\u7ec6\u80de\u4e2d\u7684STAT3\u5c31\u80fd\u6709\u6548\u963b\u65ad\u809d\u810f\u5bf9\u764c\u75c7\u201c\u79cd\u5b50\u201d\u654f\u611f\u6027\u7684\u589e\u52a0\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u4f7f\u7528\u963b<\/strong>\u65adIL-6<\/strong><\/span>\uff08\u9a71\u52a8\u4e0a\u8ff0\u8fde\u9501\u53cd\u5e94\u7684\u708e\u75c7\u4fe1\u53f7\uff09<\/span>\u7684\u6297\u4f53<\/span><\/strong>\u6765\u963b\u6b62\u4e0a\u8ff0\u8fc7\u7a0b\u80fd\u591f\u9650\u5236\u764c\u75c7\u6269\u589e\u5230\u809d\u810f\u4e2d\u7684\u6f5c\u80fd\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\n
\n
\n
\n
\n
\n
\n
\n
\n
\n

6<\/p>\n<\/section>\n<\/section>\n

\n

PNAS\uff1a\u201c\u5b9e\u529b\u8d85\u5f3a\u201d\u5316\u5408\u7269\uff0c\u76f4\u51fb\u8111\u764c\u201c\u201d<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

\u5728\u8fc7\u53bb\u5341\u5e74\u91cc\uff0c\u7814\u7a76\u4eba\u5458\u9010\u6e10\u8ba4\u8bc6\u5230\uff0c\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u764c\u75c7<\/strong>(GBM CSCs)\u662f\u8fd9\u79cd\u764c\u75c7\u201c\u6bd2\u529b\u201d\u7684\u5173\u952e\u3002\u56e0\u4e3a\u8fd9\u7c7b\u7ec6\u80de\u4e0e\u6cbb\u7597\u7684\u8010\u836f\u6027\u4ee5\u53ca\u764c\u75c7\u7684\u8f6c\u79fb\u548c\u590d\u53d1\u5bc6\u5207\u76f8\u5173\u3002<\/span><\/p>\n


<\/span><\/p>\n

3\u67087\u65e5\uff0c\u53d1\u8868\u5728PNAS\u4e0a\u7684\u4e00\u7bc7\u8bba\u6587\u4e2d[7]\uff0c\u6765\u81eaScripps Research\u7814\u7a76\u6240\u7684\u79d1\u5b66\u5bb6\u4eec\u53d1\u73b0\u4e86\u4e00\u79cd\u80fd\u6709\u6548\u9009\u62e9\u6027\u6740\u4f24GBM CSCs<\/span>\u7684\u5316\u5408\u7269\u3002<\/strong><\/span><\/p>\n

 <\/span><\/p>\n

\u7814\u7a76\u4e2d\uff0cNatasha C. Lucki\u7b49\u5efa\u7acb\u4e86\u4e00\u4e2a\u81ea\u52a8\u5316\u7684\u5927\u89c4\u6a21\u7b5b\u9009\u6d4b\u8bd5\uff0c\u5bf9\u7ea6100\u4e07\u4e2a\u5c0f\u5206\u5b50\u6709\u673a\u5316\u5408\u7269\u8fdb\u884c\u4e86\u7b5b\u9009\uff0c\u6700\u7ec8\u53d1\u73b0\uff0c\u4e00\u79cd\u540d\u4e3aRIPGBM<\/strong>\u7684\u5316\u5408\u7269\u80fd\u591f\u9009\u62e9\u6027\u6740\u6b7bGBM CSCs\uff0c\u540c\u65f6\u4e0d\u5f71\u54cd\u5065\u5eb7\u7684\u7ec6\u80de\u7c7b\u578b<\/strong>\u3002<\/span><\/p>\n


<\/span><\/p>\n

\u5f53\u88ab\u7528\u4e8e\u6740\u4f24\u57f9\u517b\u81ea\u60a3\u8005\u80bf\u7624\u7684\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u6837\u7ec6\u80de\u65f6\uff0cRIPGBM\u7684\u6548\u529b\u662f\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u6807\u51c6\u6cbb\u7597\u836f\u7269temozolomide\u768440\u500d\u4ee5\u4e0a<\/strong>\uff1b\u6b64\u5916\uff0cRIPGBM\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\u6709\u6548\u6291\u5236\u4e86\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7684\u751f\u957f\u3002\u8fdb\u4e00\u6b65\u7814\u7a76\u663e\u793a\uff0cRIPGBM\u89e6\u53d1\u4e86\u764c\u7ec6\u80de\u7684\u7ec6\u80de\u51cb\u4ea1<\/strong>\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u63a5\u4e0b\u6765\uff0c\u79d1\u5b66\u5bb6\u4eec\u5c06\u8fdb\u884c\u66f4\u591a\u7684\u52a8\u7269\u5b9e\u9a8c\uff0c\u5982\u679c\u4e00\u5207\u987a\u5229\uff0c\u6700\u540e\u5c06\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u6d4b\u8bd5RIPGBM\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\n
\n
\n
\n
\n
\n
\n
\n
\n
\n

7<\/p>\n<\/section>\n<\/section>\n

\n

Nature\u5b50\u520a\uff1a\u764c\u75c7\u201c\u9965\u997f\u201d\u7597\u6cd5\u6709\u4e86\u65b0\u201c\u9776\u70b9\u201d<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

3\u670811\u65e5\uff0c\u53d1\u8868\u5728Nature Metabolism\u4e0a\u7684\u4e00\u9879\u7814\u7a76\u4e2d[8]\uff0c\u6765\u81ea\u57c3\u9ed8\u91cc\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u4eec\u53d1\u73b0\u4e86\u4e00\u79cd\u5229\u7528\u9965\u997f\u9009\u62e9\u6027\u963b\u6b62\u767d\u8840\u75c5\u751f\u957f\u7684\u65b9\u6cd5\u3002<\/strong><\/span><\/p>\n

 <\/span><\/p>\n

\u7814\u7a76\u786e\u5b9a\u4e86\u4e00\u79cd\u65b0\u7684\u6297\u764c\u9776\u70b9\u2014\u2014\u8f6c\u8fd0\u9176ASCT2<\/strong>\u3002ASCT2\u7684\u4f5c\u7528\u662f\u8d1f\u8d23\u5c06\u8c37\u6c28\u9170\u80fa\u7b49\u51e0\u79cd\u6c28\u57fa\u9178\u201c\u5e26\u5165\u201d\u7ec6\u80de\u4e2d\u3002\u5728\u767d\u8840\u75c5\u7ec6\u80de\u4e2d\uff0cASCT2\u7684\u7f3a\u5931\u5bf9\u7ec6\u80de\u4ee3\u8c22\u4ea7\u751f\u4e86\u5168\u5c40\u6027\u7684\u5f71\u54cd\uff0c\u7834\u574f\u4e86\u4eae\u6c28\u9178\u5185\u6d41\u548cmTOR\u4fe1\u53f7\u4f20\u5bfc\uff0c\u8bf1\u5bfc\u4e86\u7ec6\u80de\u51cb\u4ea1\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u7814\u7a76\u8bc1\u5b9e\uff0c\u5220\u9664\u7f16\u7801ASCT2\u7684\u57fa\u56e0\u80fd\u591f\u5ef6\u957f\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u5c0f\u9f20\u7684\u751f\u5b58\u671f\uff1a\u4ece45\u5929\u5ef6\u957f\u5230\u8d85\u8fc7300\u5929\u3002<\/strong><\/span><\/p>\n

 <\/span><\/p>\n

\u9886\u5bfc\u8be5\u7814\u7a76\u7684Cheng-Kui Qu\u535a\u58eb\u8868\u793a\uff0c\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u5728\u6c28\u57fa\u9178\u4ee3\u8c22\u9014\u5f84\u4e2d\u5bfb\u627e\u6cbb\u7597\u9776\u70b9\u65b9\u9762\uff0c\u51e0\u4e4e\u6ca1\u6709\u53d6\u5f97\u4efb\u4f55\u8fdb\u5c55\u3002 \u5bf9\u767d\u8840\u75c5\u6765\u8bf4\uff0cASCT2\u662f\u4e00\u4e2a\u975e\u5e38\u6709\u5e0c\u671b\u7684\u6cbb\u7597\u9776\u70b9\uff0c\u56e0\u4e3a\u5b83\u5bf9\u6b63\u5e38\u7ec6\u80de\u7684\u53d1\u80b2\u53ef\u6709\u53ef\u65e0\uff0c\u4f46\u5374\u662f\u767d\u8840\u75c5\u5f62\u6210\u548c\u53d1\u5c55\u6240\u9700\u8981\u7684\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u7814\u7a76\u4eba\u5458\u5728\u79fb\u690d\u4e86\u4eba\u7c7b\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u7684\u5c0f\u9f20\u4e2d\u6d4b\u8bd5\u4e86ASCT2\u6291\u5236\u5242<\/strong>\u7684\u6709\u6548\u6027\uff0c\u5e76\u89c2\u5bdf\u5230\u4e86\u663e\u8457\u7684\u7597\u6548\u3002<\/strong>\u4e0d\u8fc7\uff0cQu\u535a\u58eb\u7b49\u4eba\u4f7f\u7528\u7684\u8fd9\u6b3e\u5019\u9009\u836f\u7269\u6548\u529b\u8f83\u4f4e\uff0c\u8fd8\u4e0d\u8db3\u4ee5\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u3002\u636e\u6089\uff0c\u7f8e\u56fd\u8303\u5fb7\u5821\u5927\u5b66\u7684Michael L  Schulte\u7b49\u53bb\u5e74\u5df2\u7ecf\u5f00\u51fa\u4e86\u4e00\u6b3e\u7279\u5f02\u6027\u7684ASCT2\u6291\u5236\uff0c\u8be5\u836f\u5bf9\u5176\u5b83\u7c7b\u578b\u7684\u764c\u75c7\u4e5f\u6709\u6d3b\u6027[9]\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\n
\n
\n
\n
\n
\n
\n
\n
\n
\n

8<\/p>\n<\/section>\n<\/section>\n

\n

\u5b50\u520a\uff1a\u4e73\u817a\u764c\u589e\u6b96\u548c\u8010\u836f\u6027\u7684\u5173\u952e\u9176\u2014\u2014USP21<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

3\u670812\u65e5\uff0c\u53d1\u8868\u5728 Reports\u4e0a\u7684\u8bba\u6587\u4e2d[10]\uff0c\u6765\u81ea\u5317\u5361\u7f57\u83b1\u7eb3\u5927\u5b66\u6559\u5802\u5c71\u5206\u6821\u7684\u79d1\u5b66\u5bb6\u4eec\u53d1\u73b0\uff0c\u4e00\u79cd\u540d\u4e3aUSP21\u7684\u9176<\/strong>\u4fc3\u8fdb\u4e86\u57fa\u5e95\u6837\u4e73\u817a\u764c\uff08basal-like breast cancer , BLBC\uff09\u7684\u589e\u6b96\uff0c\u5e76\u4e14\u5728\u5f88\u5927\u6bd4\u4f8b\u7684\u60a3\u8005\u80bf\u7624\u4e2d\u8868\u8fbe\u4e0a\u8c03\u3002<\/span><\/p>\n

 <\/span><\/p>\n

FOXM1<\/span><\/strong>\u662f\u5728BLBC\u4e2d\u5927\u91cf\u8868\u8fbe\u7684\u4e00\u79cd\u8f6c\u5f55\u56e0\u5b50\uff0c\u5bf9\u764c\u7ec6\u80de\u7ec6\u80de\u5468\u671f\u548c\u7ec6\u80de\u589e\u6b96\u7684\u201c\u6b63\u5e38\u5b8c\u6210\u201d\u81f3\u5173\u91cd\u8981\u3002\u8fd9\u9879\u65b0\u7814\u7a76\u53d1\u73b0\uff0cUSP21\u589e\u52a0\u4e86FOXM1\u7684\u4e30\u5ea6\u548c\u7a33\u5b9a\u6027\u3002<\/strong>\u7ec6\u80de\u4e2dUSP21\u8d8a\u591a\uff0cFOXM1\u5728\u7ec6\u80de\u5468\u671f\u4e2d\u53d7\u5230\u7684\u4fdd\u62a4\u8d8a\u591a\u3002\u5f53\u7814\u7a76\u4eba\u5458\u5220\u9664USP21\u65f6\uff0cFOXM1\u8f6c\u5f55\u7f51\u7edc\u76f8\u5173\u86cb\u767d\u5927\u91cf\u51cf\u5c11\uff0c\u7ec6\u80de\u5468\u671f\u8fdb\u5c55\u663e\u8457\u5ef6\u8fdf\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u7814\u7a76\u8fd8\u8bc1\u5b9e\uff0cUSP21\u7f3a\u5931\u4f7f\u5f97\u57fa\u5e95\u6837\u764c\u7ec6\u80de\u548c\u80bf\u7624\u5bf9BLBC\u7684\u4e00\u7ebf\u6cbb\u7597(\u7d2b\u6749\u9187)\u53d8\u5f97\u654f\u611f\u3002<\/strong>\u79d1\u5b66\u5bb6\u4eec\u8ba4\u4e3a\uff0c\u672a\u6765\u6709\u53ef\u80fd\u5f00\u53d1\u51fa\u4e00\u79cd\u836f\u7269\u6765\u6291\u5236USP21\uff0c\u4ee5\u201c\u8bf1\u9a97\u201d\u764c\u7ec6\u80de\u7834\u574fFOXM1\uff0c\u963b\u6b62\u764c\u7ec6\u80de\u7ee7\u7eed\u751f\u957f\u548c\u589e\u6b96\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\n
\n
\n
\n
\n
\n
\n
\n
\n
\n

9<\/p>\n<\/section>\n<\/section>\n

\n

Nature\uff1a\u538b\u529b\u8ba9\u764c\u75c7\u6076\u5316\uff0c\u5e38\u7528\u6297\u708e\u836f\u8ba9\u5316\u7597\u7597\u6548\u53d8\u5dee<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

3\u670813\u65e5\uff0c\u53d1\u8868\u5728Nature\u4e0a\u7684\u4e00\u7bc7\u8bba\u6587\u4e2d[11]\uff0c\u6765\u81ea\u745e\u58eb\u7684\u4e00\u4e2a\u79d1\u5b66\u5bb6\u56e2\u961f\u7834\u89e3\u4e86\u4e73\u817a\u764c\u8f6c\u79fb\u4e0e\u5e94\u6fc0\u6fc0\u7d20\u589e\u52a0\u76f8\u5173\u80cc\u540e\u7684\u5206\u5b50\u673a\u5236\u3002<\/strong><\/span><\/p>\n

 <\/span><\/p>\n

\u7814\u7a76\u4e2d\uff0cMilan M. S. Obradovi\u0107\u7b49\u5206\u6790\u4e86\u539f\u53d1\u6027\u80bf\u7624\u548c\u8f6c\u79fb\u6027\u80bf\u7624\u7684\u57fa\u56e0\u6d3b\u6027\uff0c\u5e76\u53d1\u73b0\u8f6c\u79fb\u6027\u80bf\u7624\u589e\u52a0\u4e86\u8d1f\u8d23\u8c03\u8282\u76ae\u8d28\u9187\u7b49\u5e94\u6fc0\u6fc0\u7d20\u4f5c\u7528\u7684\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53d7\u4f53<\/strong>\uff08glucocorticoid receptors ,GR\uff09\u7684\u6d3b\u6027\u3002\u4e0e\u80bf\u7624\u672a\u53d1\u751f\u8f6c\u79fb\u7684\u5c0f\u9f20\u76f8\u6bd4\uff0c\u80bf\u7624\u8f6c\u79fb\u7684\u5c0f\u9f20\u4f53\u5185\u5e94\u6fc0\u6fc0\u7d20\u76ae\u8d28\u9187\u548c\u76ae\u8d28\u916e\u7684\u6d53\u5ea6\u66f4\u9ad8\u3002\u8fd9\u4e9b\u5e94\u6fc0\u6fc0\u7d20\u6c34\u5e73\u589e\u52a0\u6fc0\u6d3b\u4e86GR\uff0c\u4ece\u800c\u5bfc\u81f4\u764c\u7ec6\u80de\u8f6c\u79fb\u548c\u5f02\u8d28\u6027\u589e\u52a0\uff0c\u6700\u7ec8\u7f29\u77ed\u4e86\u751f\u5b58\u671f\u3002<\/strong><\/span><\/p>\n

 <\/span><\/p>\n

\u6b64\u5916\uff0c\u7814\u7a76\u8fd8\u8bc1\u5b9e\uff0c\u5728\u764c\u75c7\u6cbb\u7597\u4e2d\u5e38\u88ab\u7528\u4e8e\u6297\u708e\u7684\u4e00\u79cd\u7cd6\u76ae\u8d28\u6fc0\u7d20\u7c7b\u836f\u7269\uff08\u5730\u585e\u7c73\u677e\uff09\u4f1a\u964d\u4f4e\u5316\u7597\u7684\u7597\u6548\u3002<\/strong>\u8fd9\u4e00\u53d1\u73b0\u8868\u660e\uff0c\u5728\u7ed9\u4e73\u817a\u764c\u60a3\u8005\u5f00\u7cd6\u76ae\u8d28\u6fc0\u7d20\u5904\u65b9\u65f6\u5e94\u8c28\u614e\uff1b\u6b64\u5916\uff0c\u6291\u5236\u7cd6\u76ae\u8d28\u6fc0\u7d20\u53d7\u4f53\u53ef\u80fd\u4f1a\u5bf9\u60a3\u8005\u6709\u76ca\u3002\u8fd9\u7ed9\u5f00\u53d1\u5bf9\u6297\u4e73\u817a\u764c\u8f6c\u79fb\u7684\u65b0\u7597\u6cd5\u63d0\u4f9b\u4e86\u65b9\u5411\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\n
\n
\n
\n
\n
\n
\n
\n
\n
\n

10<\/span><\/p>\n<\/section>\n<\/section>\n

\n

Nature\u5b50\u520a\uff1a\u4e00\u79cd\u5173\u952e\u9176\uff0c\u5173\u4e4e\u591a\u79cd\u764c\u75c7\u6cbb\u7597<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


<\/p>\n

3\u670815\u65e5\uff0c\u53d1\u8868\u5728Nature Communications\u4e0a\u7684\u4e00\u7bc7\u8bba\u6587\u4e2d[12]\uff0c\u4e2d\u7f8e\u79d1\u5b66\u5bb6\u53d1\u73b0\uff0c\u4e00\u79cd\u88ab\u79f0\u4e3aUSP15\u7684\u9176\u53ef\u80fd\u4f1a\u5e26\u6765\u4e73\u817a\u764c\u548c\u80f0\u817a\u764c\u7684\u65b0\u7597\u6cd5\u3002<\/strong><\/span><\/p>\n

 <\/span><\/p>\n

USP15<\/span><\/strong>\u5c5e\u4e8e\u53bb\u6cdb\u7d20\u9176\uff0c\u8d1f\u8d23\u53bb\u9664\u86cb\u767d\u8d28\u548c\u5176\u5b83\u5206\u5b50\u4e2d\u7684\u6cdb\u7d20\u94fe\uff0c\u5728\u7ef4\u6301\u57fa\u56e0\u7ec4\u7a33\u5b9a\u6027\u65b9\u9762\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002\u764c\u75c7\u57fa\u56e0\u7ec4\u56fe\u8c31<\/span>\uff08Cancer Genome Atlas\uff09<\/span>\u663e\u793a\uff0cUSP15\u7684\u7f3a\u5931\u53d1\u751f\u572816%\u7684\u4e73\u817a\u764c\u548c5%\u7684\u80f0\u817a\u764c\u4e2d\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\u8fd9\u9879\u65b0\u7814\u53d1\u53d1\u73b0\uff0cUSP15\u901a\u8fc7\u8c03\u8282\u540c\u6e90\u91cd\u7ec4<\/strong><\/span>\uff08\u4fee\u590dDNA\u635f\u4f24\u7684\u4e3b\u8981\u9014\u5f84\u4e4b\u4e00\uff09<\/span>\u5f71\u54cd\u7740\u764c\u7ec6\u80de\u5bf9PARP\u6291\u5236\u5242<\/span><\/strong>\uff08\u4e00\u79cd\u65b0\u578b\u836f\u7269\u6291\u5236\u5242\uff0c\u4e3b\u8981\u88ab\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u764c\u75c7\uff0c\u56e0\u5bf9\u6cbb\u7597\u643a\u5e26BRCA\u7a81\u53d8\u7684\u60a3\u8005\u5177\u6709\u6f5c\u529b\u88ab\u5e7f\u6cdb\u5173\u6ce8\uff09<\/span>\u7684\u54cd\u5e94\u3002\u4e0e\u764c\u75c7\u76f8\u5173\u7684USP15\u7a81\u53d8\u589e\u52a0\u4e86\u764c\u7ec6\u80de\u5bf9PARP\u6291\u5236\u5242\u7684\u654f\u611f\u6027\u3002<\/span><\/strong><\/p>\n

 <\/span><\/p>\n

\u603b\u7ed3\u6765\u8bf4\uff0c\u4f5c\u8005\u4eec\u8ba4\u4e3a\uff0c\u4ed6\u4eec\u9274\u5b9a\u51fa\u4e86\u540c\u6e90\u91cd\u7ec4\u7684\u65b0\u8c03\u8282\u56e0\u5b50\u2014\u2014USP15\uff0c\u4e14USP15\u662fPARP\u6291\u5236\u5242\u7684\u6f5c\u5728\u751f\u7269\u6807\u5fd7\u7269\u3002<\/span><\/p>\n

 <\/span><\/p>\n

\n
\n

<\/span><\/strong><\/p>\n

\u76f8\u5173\u8bba\u6587\uff1a<\/span><\/strong><\/p>\n

[1] <\/span><\/strong>Kirsten L. Bryant et al.Combinationof ERK and autophagy inhibition as a treatment approach for pancreatic cancer. NatureMedicine (2019).<\/span><\/p>\n

[2] <\/span><\/strong>Conan G. Kinsey et al.Protectiveautophagy elicited by RAF\u2192MEK\u2192ERK inhibition suggests a treatment strategy forRAS-driven cancers. Nature Medicine (2019).<\/span><\/p>\n

[3] <\/span><\/strong>Meike E. W. Logtenberg et al.Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRP\u03b1 axis and atarget for cancer immunotherapy. Nature Medicine (2019).<\/span><\/p>\n

[4] <\/span><\/strong>Ilana Chefetz et al. APan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like s. Reports(2019).<\/span><\/p>\n

[5] <\/span><\/strong>JiyoungLee et al.Effective breast cancer combination therapy targeting BACH1 andmitochondrialmetabolism. Nature\uff082019\uff09.<\/span><\/p>\n

[6] <\/span><\/strong>Jae W. Lee et al. Hepatocytesdirect the formation of a pro-metastatic niche in the liver. Nature\uff082019\uff09.<\/span><\/p>\n

[7] <\/span><\/strong>Natasha C. Lucki et al. A cell type-selective apoptosis-inducing small moleculefor the treatment of brain cancer. PNAS(2019).<\/span><\/p>\n

[8] <\/span><\/strong>Fang Ni et al. Critical role ofASCT2-mediated amino acid metabolism in promoting leukaemia development andprogression. Nature Metabolism\uff082019\uff09.<\/span><\/p>\n

[9]<\/span><\/strong> Michael L Schulte et al. Pharmacological blockadeof ASCT2-dependent glutamine transport leads to antitumor efficacy inpreclinical models. Nature Medicine(2018).<\/span><\/p>\n

[10]<\/span><\/strong> Anthony Arceci et al. FOXM1 Deubiquitinationby USP21 Regulates Cycle Progression and Paclitaxel Sensitivity inBasal-like Breast Cancer. Reports (2019).<\/span><\/p>\n

[11] <\/span><\/strong>MilanM. S. Obradovi\u0107 etal. Glucocorticoids promote breast cancer metastasis. Nature(2019).<\/span><\/p>\n

[12] <\/span><\/strong>Yihan Peng et al. Thedeubiquitylating enzyme USP15 regulates homologous recombination repair andcancer cell response to PARP inhibitors. Nature Communications(2019).<\/span><\/p>\n

 <\/span><\/p>\n

\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/strong><\/p>\n

1#<\/span><\/strong> Potential treatment strategyuncovered for pancreatic cancer<\/span><\/p>\n

2#<\/span><\/strong> Promising new pancreatic cancertreatment moves forward<\/span><\/p>\n

3#<\/span><\/strong> New strategy to tackle ‘don’teat me’ signal on cancer cells<\/span><\/p>\n

4#<\/span><\/strong> Targeting stem-like cells couldprevent ovarian cancer recurrence<\/span><\/p>\n

5#<\/span><\/strong> Olddrugs bringnew hope to a cancer that lacks precision therapy<\/span><\/p>\n

6#<\/span><\/strong> Cancer most frequently spreadsto the liver; here’s why<\/span><\/p>\n

7# <\/span><\/strong>Promising compound selectivelykills brain cancer stem cells<\/span><\/p>\n

8# <\/span><\/strong>Starving leukemia cells bytargeting amino acids<\/span><\/p>\n

9#<\/span><\/strong> Scientists discover key enzyme inbreast cancer proliferation, treatment resistance<\/span><\/p>\n

10#<\/span><\/strong> Stresshormonespromote breast cancer metastasis<\/span><\/p>\n

11#<\/span><\/strong> Enzyme USP15 may have potentialrole in future treatment of various cancer<\/span><\/p>\n<\/section>\n<\/section>\n

\n


<\/p>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

\u8f6c\u81ea\u533b\u836f\u9b54\u65b9 \u6742\u5fd7\uff1aNature\u3001PNAS\u7b49 \u4eae\u70b9\uff1a 1\uff09\u5bf9\u6297\u4e09\u9634\u6027\u4e73\u817a\u764c\uff0c\u4e8c\u7532\u53cc\u80cd\u8054\u5408\u6cbb\u7597\u4ee4\u4eba\u671f\u5f85 2\uff09\u764c\u75c7 […]<\/p>\n","protected":false},"author":1,"featured_media":82338,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/82337"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=82337"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/82337\/revisions"}],"predecessor-version":[{"id":82339,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/82337\/revisions\/82339"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/82338"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=82337"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=82337"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=82337"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}