{"id":82371,"date":"2019-03-13T00:00:50","date_gmt":"2019-04-11T07:00:25","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/82371\/"},"modified":"2019-04-11T15:00:27","modified_gmt":"2019-04-11T07:00:27","slug":"d58d01b69b","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/82371\/","title":{"rendered":"\u809d\u75c5\u836f\u7269\u5965\u8d1d\u80c6\u9178\u4e13\u5229\u5e03\u5c40\u5206\u6790"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section class=\"_editor\">\n<section style=\"margin-top: 10px;margin-bottom: 10px;\">\n<section style=\"margin-right:auto;margin-top: 20px;margin-bottom: 20px;\">\n<p style=\"text-align: left;background-color:#fffffe;display:inline-block;\">\n<\/section>\n<section style=\"margin-top: -33px;border-style: solid;border-width: 1px;border-color: #9fa6d8;padding: 15px 15px;box-sizing: border-box;\">\n<p style=\"letter-spacing: 2px;text-align: justify;\"><span style=\"font-size: 14px;\"><strong><span style=\"color: rgb(0, 82, 255);\">\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08Nonalcoholic steatohepatitis\uff0cNASH\uff09<\/span><\/strong>\u662f\u4e00\u4e2a\u5b58\u5728\u5de8\u5927\u672a\u6ee1\u8db3\u9700\u6c42\u3001\u6025\u9700\u65b0\u836f\u7684\u9886\u57df\uff0c\u76ee\u524d\u5c1a\u65e0\u6b63\u5f0f\u83b7\u6279\u836f\u7269\uff0c\u4f46\u53c8\u5145\u6ee1\u4e86\u5e0c\u671b\u30022019\u5e742\u6708\u4efd\u4f3c\u4e4e\u53ef\u88ab\u79f0\u4e3aNASH\u6708\uff0cNASH\u9886\u57df\u4f20\u6765\u591a\u6761\u91cd\u78c5\u6d88\u606f\uff0c\u559c\u5fe7\u53c2\u534a\uff0c\u5176\u4e2d\u6700\u4e3a\u632f\u594b\u7684\u662fIntercept\u5236\u836f\u516c\u53f8\uff08ICPT\uff09\u516c\u5e03\u4e86\u5176NASH\u65b0\u836f\u2014\u2014\u6cd5\u5c3c\u916fX\u53d7\u4f53\uff08Farnesoid X receptor\uff0cFXR\uff09\u7279\u5f02\u6027\u6fc0\u52a8\u5242<strong><span style=\"color: rgb(0, 82, 255);\">\u5965\u8d1d\u80c6\u9178\uff08OCA\uff09<\/span><\/strong>\u7684\u7b2c\u4e00\u4e2a\u540d\u4e3aRegenerate\u7684\u2162\u671f\u4e34\u5e8a\u9876\u5c42\u5206\u6790\u7ed3\u679c\u3002\u672c\u6587\u5bf9<span style=\"color: rgb(0, 82, 255);\"><strong>\u79d1\u777f\u552f\u5b89Integrity<\/strong><\/span>\u6570\u636e\u5e93\u6536\u5f55\u516c\u5f00\u7684\u6709\u5173NASH\u5728\u7814\u836f\u7269\u5965\u8d1d\u80c6\u9178\u7684<span style=\"color: rgb(0, 82, 255);\"><strong>\u4e13\u5229<\/strong><\/span>\u7533\u8bf7\u8fdb\u884c\u4e86\u68b3\u7406\uff0c\u5e76\u91cd\u70b9\u5206\u6790\u4e86\u5965\u8d1d\u80c6\u9178\u539f\u7814\u673a\u6784Intercept\u516c\u53f8\u7684\u4e13\u5229\u5e03\u5c40\u72b6\u51b5\u3002<\/span><\/p>\n<\/section>\n<section style=\"margin-right:20px;float:right;margin-top:-10px;\">\n<p style=\"text-align: left;background-color:#fffffe;display:inline-block;\"><img class=\"\"     src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/4-1554966025.png\" alt=\"\u809d\u75c5\u836f\u7269\u5965\u8d1d\u80c6\u9178\u4e13\u5229\u5e03\u5c40\u5206\u6790\" title=\"\u809d\u75c5\u836f\u7269\u5965\u8d1d\u80c6\u9178\u4e13\u5229\u5e03\u5c40\u5206\u6790\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"_editor\">\n<section style=\"text-align: center;\">\n<section style=\"border-bottom:solid;border-width:1px;border-color:rgb(176, 197, 255);display:inline-block;padding:3px 15px;\">\n<p><strong><span style=\"color: rgb(0, 128, 255);\">1.&nbsp;\u5965\u8d1d\u80c6\u9178\u7b80\u4ecb<\/span><\/strong><\/p>\n<\/section>\n<section style=\"margin-left: auto;margin-right: auto;margin-top: -5px;transform: rotateZ(45deg);width: 10px;height: 10px;background-color: rgb(176, 197, 255);\"><br  \/><\/section>\n<\/section>\n<\/section>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u5965\u8d1d\u80c6\u9178\uff08Obeticholic acid\uff0cOCA\uff0cINT-747\uff0c\u5546\u54c1\u540dOcaliva\uff09\u662f\u7531\u610f\u5927\u5229\u4f69\u9c81\u8d3e\uff08Perugia\uff09\u5927\u5b66\u6700\u5148\u7814\u53d1\uff0c\u53d1\u73b0\u5176\u5316\u5408\u7269\u7ed3\u6784\uff0c\u540e\u6765\u6388\u6743\u7ed9\u603b\u90e8\u8bbe\u5728\u7f8e\u56fd\u7ebd\u7ea6\u5e02\u7684\u4e00\u5bb6\u751f\u7269\u5236\u836f\u516c\u53f8Intercept\u5236\u836f\u516c\u53f8\uff08ICPT\uff09\uff0c\u968f\u540e\uff0c\u8be5\u516c\u53f8\u5c06\u4e9a\u6d32\uff08\u5305\u62ec\u4e2d\u56fd\u3001\u65e5\u672c\u548c\u97e9\u56fd\uff09\u7684\u5f00\u53d1\u6743\u6388\u6743\u7ed9\u65e5\u672c\u4f4f\u53cb\u682a\u5f0f\u4f1a\u793e\uff08Sumitomo Dainippon Pharma\uff09\u3002<br  \/><\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u5965\u8d1d\u80c6\u9178\u662f\u4e00\u79cd\u534a\u5408\u6210\u7684\u9e45\u53bb\u6c27\u80c6\u9178\u7c7b\u4f3c\u72696\u03b1-\u4e59\u57fa\u9e45\u53bb\u6c27\u80c6\u9178\uff08\u5316\u5b66\u7ed3\u6784\u89c1\u56fe1\uff09\uff0c\u5176\u662f\u4e00\u79cd\u6cd5\u5c3c\u916fX\u53d7\u4f53\uff08Farnesoid X receptor\uff0cFXR\uff09\u7279\u5f02\u6027\u6fc0\u52a8\u5242\u3002FXR\u662f\u4e00\u79cd\u6838\u6fc0\u7d20\u53d7\u4f53\uff0c\u5176\u914d\u4f53\u4e3a\u80c6\u6c41\u9178\uff0c\u5728\u8c03\u8282\u8102\u8d28\u548c\u8461\u8404\u7cd6\u4ee3\u8c22\u53ca\u708e\u75c7\u548c\u7ea4\u7ef4\u5316\u8fc7\u7a0b\u4e2d\u5177\u6709\u5173\u952e\u4f5c\u7528\u3002\u5965\u8d1d\u80c6\u9178\u95f4\u63a5\u6291\u5236\u7ec6\u80de\u8272\u7d207A1\uff08CYP7A1\uff09\u7684\u57fa\u56e0\u8868\u8fbe\uff0c\u6291\u5236\u80c6\u9178\u5408\u6210\u548c\u964d\u4f4e\u9759\u8109\u9ad8\u538b\u4f5c\u7528\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"        style=\"width: 224px;height: 146px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/5-1554966026.png\" alt=\"\u809d\u75c5\u836f\u7269\u5965\u8d1d\u80c6\u9178\u4e13\u5229\u5e03\u5c40\u5206\u6790\" title=\"\u809d\u75c5\u836f\u7269\u5965\u8d1d\u80c6\u9178\u4e13\u5229\u5e03\u5c40\u5206\u6790\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\">\u56fe1\uff1a\u5965\u8d1d\u80c6\u9178\u5316\u5b66\u7ed3\u6784<\/span><\/p>\n<p style=\"font-family: 8px 0;text-indent: 28px;line-height: 24px;\"><span style=\"font-size: 14px;font-family: \u534e\u6587\u7ec6\u9ed1;color: windowtext;\"><\/span><br  \/><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u4f5c\u4e3aFXR\u6fc0\u52a8\u5242\u7684\u5965\u8d1d\u80c6\u9178\u662f\u5929\u7136\u80c6\u6c41\u9178\u9e45\u53bb\u6c27\u80c6\u9178\u7684\u534a\u5408\u6210\u884d\u751f\u7269\uff0c\u5176\u4ee5\u66f4\u9ad8\u7684\u6548\u529b\u7ed3\u5408FXR\u3002\u5728\u80a5\u80d6\u52a8\u7269\u4e2d\uff0c\u5965\u8d1d\u80c6\u9178\u6cbb\u7597\u53ef\u663e\u8457\u964d\u4f4e\u9ad8\u8102\u80aa\u548c\u9ad8\u80c6\u56fa\u9187\u5582\u517b\u5c0f\u9f20\u4f53\u91cd\u7684\u589e\u52a0\u548c\u8840\u6d46\u8461\u8404\u7cd6\u3001\u80c6\u56fa\u9187\u3001\u7518\u6cb9\u4e09\u916f\uff08TG\uff09\u548c\u8102\u80aa\u9178\uff08FA\uff09\u542b\u91cf\uff1b\u540c\u65f6\uff0c\u5965\u8d1d\u80c6\u9178\u80fd\u51cf\u5c11Zucker\uff08fa\/fa\uff09\u809d\u810f\u5927\u9f20\u7684\u8840\u8102\u548c\u8102\u80aa\u53d8\u6027\u3002\u5965\u8d1d\u80c6\u9178\u7ed9\u836f\u663e\u8457\u964d\u4f4e\u4e86\u7ea4\u7ef4\u751f\u6210\u76f8\u5173\u86cb\u767d\uff08a-SMA\u3001Col1a1\u3001TIMP1\u548cTIMP2\uff09\u7684\u6c34\u5e73\uff0c\u5e76\u4fdd\u62a4\u96c4\u6027\u5927\u9f20\u514d\u53d7CCl4\u6216\u80c6\u7ba1\u7ed3\u624e\uff08BDL\uff09\u8bf1\u5bfc\u7684\u809d\u7ea4\u7ef4\u5316\u3002\u5965\u8d1d\u80c6\u9178\u7ed9\u836f\u4fc3\u8fdbCCl4\u548cBDL\u8bf1\u5bfc\u7684\u7ea4\u7ef4\u5316\u6a21\u578b\u4e2d\u7684\u809d\u7ea4\u7ef4\u5316\u6d88\u9000\u3002\u6b64\u5916\uff0c\u5965\u8d1d\u80c6\u9178\u6cbb\u7597\u663e\u8457\u964d\u4f4e\u4e86\u7531\u786b\u4ee3\u4e59\u9170\u80fa\uff08TAA\uff09\u8bf1\u5bfc\u7684\u809d\u786c\u5316\u5927\u9f20\u7684\u809d\u7ea4\u7ef4\u5316\u3001\u708e\u75c7\u3001\u8840\u6d46\u8c37\u4e19\u8f6c\u6c28\u9176\uff08ALT\uff09\u6c34\u5e73\u548c\u809d\u7f9f\u812f\u6c28\u9178\u542b\u91cf\u3002\u7ecf\u5965\u8d1d\u80c6\u9178\u6cbb\u7597\u540e\uff0c\u4fc3\u7ea4\u7ef4\u5316\u7ec6\u80de\u56e0\u5b50CTGF\u3001TGF-\u03b21\u548cPDGF\u03b2-R\u4e5f\u964d\u4f4e\u3002\u5965\u8d1d\u80c6\u9178\u51cf\u5c11\u809d\u7ea4\u7ef4\u5316\u4e0e\u901a\u8fc7\u4e0a\u8c03IkB\u03b1\u964d\u4f4eNF-kB\u9014\u5f84\u6d3b\u6027\u6709\u5173\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u5965\u8d1d\u80c6\u9178\u4e8e2016\u5e745\u670827\u65e5\u7531\u7f8e\u56fdFDA\u6709\u6761\u4ef6\u52a0\u901f\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u6210\u4eba\u539f\u53d1\u6027\u80c6\u6c41\u6027\u80c6\u7ba1\u708e\uff08Primarybiliary cholangitis\uff0cPBC\uff09\uff0c\u8054\u5408\u718a\u53bb\u6c27\u80c6\u9178\uff08UDCA\uff09\u7528\u4e8eUDCA\u5355\u836f\u6cbb\u7597\u5e94\u7b54\u4e0d\u4f73\u7684\u539f\u53d1\u6027\u80c6\u6c41\u6027\u80c6\u7ba1\u708e\uff08PBC\uff09\u6210\u4eba\u60a3\u8005\uff0c\u6216\u5355\u836f\u7528\u4e8e\u65e0\u6cd5\u8010\u53d7UDCA\u7684PBC\u6210\u4eba\u60a3\u8005\u3002\u8be5\u9002\u5e94\u75c7\u57282016\u5e7412\u670812\u65e5\u4e5f\u83b7\u5f97\u4e86\u6b27\u76dfEMA\u7684\u6709\u6761\u4ef6\u6279\u51c6\u3002\u5965\u8d1d\u80c6\u9178\u662f\u8fd120\u5e74\u6765\u9996\u4e2a\u83b7\u6279\u6cbb\u7597PBC\u7684\u836f\u7269\u3002\u7531\u4e8ePBC\u662f\u4e00\u79cd\u7f55\u89c1\u75c5\uff0c\u5965\u8d1d\u80c6\u9178\u57282010\u5e74\u5f97\u5230\u4e86\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40\u7684\u5b64\u513f\u836f\u59d4\u5458\u4f1a\uff08COMP\uff09\u7684\u5b64\u513f\u836f\u8d44\u683c\u8ba4\u5b9a\u3002\u4f5c\u4e3a\u6fc0\u52b1\u63aa\u65bd\uff0c\u5b64\u513f\u836f\u53ef\u83b7\u5f97\u5341\u5e74\u7684\u5e02\u573a\u72ec\u5bb6\u7ecf\u8425\u6743\u3002FDA\u4e5f\u5df2\u6388\u4e88\u5965\u8d1d\u80c6\u9178\u6cbb\u7597\u4f34\u6709\u809d\u7ea4\u7ef4\u5316\u7684\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08Nonalcoholic steatohepatitis\uff0cNASH\uff09\u7684\u7a81\u7834\u6027\u836f\u7269\u8d44\u683c\u3001\u6cbb\u7597PBC\u7684\u5feb\u901f\u901a\u9053\u5730\u4f4d\u3001\u6cbb\u7597PBC\u548c\u539f\u53d1\u6027\u786c\u5316\u6027\u80c6\u7ba1\u708e\uff08Primary sclerosing cholangitis\uff0cPSC\uff09\u7684\u5b64\u513f\u836f\u5730\u4f4d\u3002\u4e2d\u56fd\u76ee\u524d\u65e0\u5965\u8d1d\u80c6\u9178\u539f\u7814\u548c\u4eff\u5236\u836f\u6ce8\u518c\u4fe1\u606f\uff0c\u4f46\u503c\u5f97\u5173\u6ce8\u7684\u662f\uff0c\u6c5f\u82cf\u6052\u745e\u548c\u6b63\u5927\u5929\u6674\u4eff\u5236\u5904\u4e8e\u4e34\u5e8a\u72b6\u6001\u4e2d\uff0c\u5e76\u8fdb\u884c\u53c2\u6bd4\u5236\u5242\u5907\u6848\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">2017\u5e746\u670822\u65e5\uff0c\u5965\u8d1d\u80c6\u9178\u836f\u7269\u88ab\u6388\u4e882017 Premio Galeno Italia\uff08Prix Galien Italia 2017\uff09\u5316\u5b66\u5408\u6210\u836f\u7269\u5956\u3002Prix Galien Italia\u5316\u5b66\u5408\u6210\u836f\u7269\u5956\u662f\u610f\u5927\u5229\u751f\u547d\u79d1\u5b66\u884c\u4e1a\u6700\u53d7\u8ba4\u53ef\u7684\u8363\u8a89\u4e4b\u4e00\uff0c\u8be5\u5956\u9879\u6388\u4e88\u521b\u65b0\u836f\u7269\u5965\u8d1d\u80c6\u9178\uff0c\u5956\u52b1\u5176\u4f5c\u4e3aPBC\u7684\u65b0\u578b\u6cbb\u7597\u65b9\u6848\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">2019\u5e742\u670819\u65e5\uff0cIntercept\u516c\u53f8\u5ba3\u5e03\u5965\u8d1d\u80c6\u9178\u9488\u5bf9\u4f34\u67092\uff5e3\u7ea7\u809d\u7ea4\u7ef4\u5316\u7684NASH\u60a3\u8005\u7684\u5173\u952e\u2162\u671fRegenerate\u7814\u7a76\u7684\u671f\u4e2d\u5206\u6790\u53d6\u5f97\u79ef\u6781\u7ed3\u679c\u3002\u8be5\u4e34\u5e8a\u7814\u7a76\u4e3b\u8981\u7ec8\u70b9\u7684\u7597\u6548\u6570\u636e\u663e\u793a\uff1a1\uff09\u5965\u8d1d\u80c6\u917825mg\u6bcf\u65e51\u6b21\u6cbb\u7597\u7ec4\u7b2c18\u4e2a\u6708\u65f6\uff0c\u809d\u7ea4\u7ef4\u5316\u7a0b\u5ea6\u81f3\u5c11\u6539\u55841\u7ea7\u4e14NASH\u6ca1\u6709\u6076\u5316\u7684\u60a3\u8005\u6bd4\u4f8b\u663e\u8457\u9ad8\u4e8e\u5b89\u6170\u5242\u7ec4\uff08\u5206\u522b\u4e3a23.1%\u300111.9%\uff0cp=0.0002\uff09\uff1b2\uff09\u5965\u8d1d\u80c6\u917810mg\u548c25mg\u6cbb\u7597\u7ec4\u7b2c18\u4e2a\u6708\u65f6\uff0cNASH\u7ec4\u7ec7\u75c5\u7406\u5b66\u6539\u5584\uff08\u8102\u80aa\u84c4\u79ef\u51cf\u5c11\uff09\u4e14\u7ea4\u7ef4\u5316\u7a0b\u5ea6\u6ca1\u6709\u6076\u5316\u7684\u60a3\u8005\u6bd4\u4f8b\u8f83\u5b89\u6170\u5242\u7ec4\u5747\u6709\u63d0\u9ad8\uff0c\u4f46\u662f\u5728\u7edf\u8ba1\u4e0a\u6ca1\u6709\u663e\u8457\u5dee\u5f02\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u5b89\u5168\u6027\u65b9\u9762\uff0cRegenerate\u7814\u7a76\u4e2d\u7684\u4e0d\u826f\u4e8b\u4ef6\u901a\u5e38\u4e3a\u8f7b\u81f3\u4e2d\u5ea6\u3002\u6700\u5e38\u89c1\u7684\u4e0d\u826f\u4e8b\u4ef6\u4e0e\u5965\u8d1d\u80c6\u9178\u4e4b\u524d\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7684\u7ed3\u679c\u57fa\u672c\u4e00\u81f4\uff0c\u4e3b\u8981\u662f\u4e0e\u5242\u91cf\u76f8\u5173\u7684\u7619\u75d2\uff0c\u5728\u5b89\u6170\u5242\u7ec4\u548c\u5965\u8d1d\u80c6\u917810mg\u300125mg\u7ec4\u7684\u53d1\u751f\u7387\u5206\u522b\u4e3a19%\u300128%\u548c51%\u3002\u5927\u591a\u6570\u7619\u75d2\u4e8b\u4ef6\u4e3a\u8f7b\u81f3\u4e2d\u5ea6\uff0c\u91cd\u5ea6\u7619\u75d2\u57283\u7ec4\u7684\u53d1\u751f\u7387\u5206\u522b\u4e3a&lt;1%\u3001&lt;1%\u548c5%\u30023\u7ec4\u56e0\u4e3a\u4e25\u91cd\u7619\u75d2\u800c\u7ec8\u6b62\u6cbb\u7597\u7684\u60a3\u8005\u6bd4\u4f8b\u5206\u522b\u4e3a&lt;1%\u3001&lt;1%\u548c9%\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">3\u4e2a\u6cbb\u7597\u7ec4\u7684\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u53d1\u751f\u7387\u7c7b\u4f3c\uff0811%\u300111%\u548c14%\uff09\uff0c\u5404\u7ec4\u672a\u89c1\u53d1\u751f\u7387\u53d1\u751f\u7387\u8d85\u8fc71%\u7684\u4efb\u4f55\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u30023\u4f8b\u60a3\u8005\u6b7b\u4ea1\uff0c\u4f46\u5747\u4e0e\u836f\u7269\u6cbb\u7597\u65e0\u5173\u3002\u5176\u4e2d\uff0c\u5b89\u6170\u5242\u7ec42\u4f8b\u5206\u522b\u6b7b\u4e8e\u9aa8\u764c\u548c\u5fc3\u810f\u505c\u535a\uff0c\u5965\u8d1d\u80c6\u917825mg\u7ec41\u4f8b\u6b7b\u4e8e\u8111\u80f6\u8d28\u7624\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u6b64\u5916\uff0c\u5965\u8d1d\u80c6\u9178\u6cbb\u7597\u76f8\u5173\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u80c6\u56fa\u9187\uff08LDL-C\uff09\u6c34\u5e73\u5347\u9ad8\u5728Regenerate\u7814\u7a76\u4e2d\u4e5f\u6709\u89c1\u5230\uff0c\u5728\u7b2c4\u5468\u65f6\u4f1a\u8fbe\u523022.6mg\/dL\u7684\u5cf0\u503c\uff0c\u4e4b\u540e\u4f1a\u9010\u6e10\u56de\u590d\u523018mg\/dL\u57fa\u7ebf\u6c34\u5e73\u30023\u7ec4\u60a3\u8005\u7684\u4e25\u91cd\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u5c11\u89c1\u4e14\u4e34\u5e8a\u8868\u73b0\u6709\u8f83\u5927\u5dee\u5f02\uff0c\u53d1\u751f\u7387\u5206\u522b\u4e3a2%\u30011%\u548c2%\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u5965\u8d1d\u80c6\u9178\u662f\u5168\u7403\u7b2c\u4e00\u4e2a\u8fdb\u5165\u2162\u671f\u4e34\u5e8a\u7684NASH\u5728\u7814\u836f\u7269\u3002Regenerate\u7814\u7a76\u4e8e2015\u5e749\u6708\u6b63\u5f0f\u542f\u52a8\uff0c\u662f\u610f\u4e49\u975e\u5e38\u5b8f\u5927\u7684\u4e00\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u539f\u8ba1\u5212\u5168\u7403\u62db\u52df2500\u540d\u60a3\u8005\uff0c\u7ed9\u836f72\u5468\uff0818\u4e2a\u6708\uff09\uff0c\u5b8c\u6210\u5165\u7ec41400\u4f8b\u60a3\u8005\u540e\u8fdb\u884c\u671f\u4e2d\u5206\u6790\u3002\u7531\u4e8e\u8fd9\u4e2a\u8bd5\u9a8c\u7684\u5165\u7ec4\u548c\u590d\u5408\u7ec8\u70b9\u6307\u6807\u68c0\u6d4b\u9700\u8981\u5bf9\u60a3\u8005\u8fdb\u884c\u809d\u7ec4\u7ec7\u6d3b\u68c0\uff0c\u5b9e\u65bd\u96be\u5ea6\u8f83\u5927\uff0c\u5bfc\u81f4\u60a3\u8005\u62db\u52df\u8fdf\u7f13\uff0c\u8bd5\u9a8c\u8fdb\u5ea6\u4e0d\u751a\u7406\u60f3\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">2017\u5e742\u6708\uff0cIntercept\u516c\u53f8\u5ba3\u5e03\u4e0eFDA\u8fdb\u884c\u4e86\u6c9f\u901a\u5e76\u83b7\u5f97\u4e86FDA\u7684\u8bb8\u53ef\uff0c\u5c06\u6ee1\u8db3\u671f\u4e2d\u5206\u6790\u7684\u60a3\u8005\u4eba\u6570\u6761\u4ef6\u4ece1400\u4eba\u6539\u4e3a750\u4eba\uff0c\u540c\u65f6\uff0c\u5c06\u8bd5\u9a8c\u6210\u529f\u7684\u6807\u51c6\u4ece\u5230\u8fbe\u590d\u5408\u7ec8\u70b9\u66f4\u6539\u4e3a\u53ea\u8981\u5230\u8fbe\u5176\u4e2d\u4e00\u4e2a\u7ec8\u70b9\u3002\u5728\u8bd5\u9a8c\u96be\u5ea6\u964d\u4f4e\u4e4b\u540e\uff0cIntercept\u516c\u53f8\u539f\u672c\u9884\u671f\u662f2017\u5e74\u5e74\u4e2d\u5c31\u53ef\u4ee5\u8fdb\u884c\u671f\u4e2d\u5206\u6790\uff0c\u4f46\u76f4\u52302019\u5e74\u521d\u624d\u516c\u5e03\u671f\u4e2d\u5206\u6790\u7ed3\u679c\uff0c\u8fd9\u4e5f\u5370\u8bc1\u4e86NASH\u65b0\u836f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u63a8\u8fdb\u96be\u5ea6\u4e4b\u5927\uff0c\u5305\u62ec\u60a3\u8005\u5bf9\u75be\u75c5\u7684\u8ba4\u77e5\u4e0d\u5145\u5206\uff0cNASH\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7ec8\u70b9\u8bbe\u7f6e\u6807\u51c6\u4e0d\u7edf\u4e00\u7b49\u65b9\u9762\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u4e0d\u7ba1\u5916\u90e8\u73af\u5883\u5982\u4f55\u53d8\u5316\uff0c\u5965\u8d1d\u80c6\u9178\u7ec8\u5f52\u662f\u7b2c\u4e00\u4e2a\u5728\u5173\u952e\u2162\u671f\u7814\u7a76\u4e2d\u53d6\u5f97\u6210\u529f\u7684NASH\u65b0\u836f\u3002Intercept\u516c\u53f8\u8ba1\u5212\u57282019\u5e74\u4e0b\u534a\u5e74\u5411FDA\u548cEMA\u63d0\u4ea4\u5965\u8d1d\u80c6\u9178\u7528\u4e8e\u6cbb\u7597NASH\u7684\u65b0\u836f\u4e0a\u5e02\u7533\u8bf7\u3002\u5965\u8d1d\u80c6\u9178\u4e5f\u662f\u76ee\u524d\u552f\u4e00\u4e00\u4e2a\u88abFDA\u6388\u4e88\u6cbb\u7597\u4f34\u6709\u809d\u7ea4\u7ef4\u5316NASH\u60a3\u8005\u7684\u7a81\u7834\u6027\u7597\u6cd5\u8d44\u683c\u7684\u836f\u7269\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><br  \/><\/p>\n<section class=\"_editor\">\n<section style=\"text-align: center;\">\n<section style=\"border-bottom:solid;border-width:1px;border-color:#b0c5ff;display:inline-block;padding:3px 15px;\">\n<p style=\"letter-spacing: 2px;\"><strong><span style=\"color: rgb(0, 128, 255);font-size: 15px;text-align: justify;text-indent: 34px;\">2.&nbsp;\u5965\u8d1d\u80c6\u9178\u5168\u7403\u4e13\u5229\u7533\u8bf7\u60c5\u51b5<\/span><\/strong><\/p>\n<\/section>\n<section style=\"margin-left: auto;margin-right: auto;margin-top: -5px;transform: rotateZ(45deg);width: 10px;height: 10px;background-color: rgb(176, 197, 255);\"><br  \/><\/section>\n<\/section>\n<\/section>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u636e\u79d1\u777f\u552f\u5b89Integrity\u6570\u636e\u5e93\uff08\u68c0\u7d22\u65e5\u671f\uff1a2019\u5e742\u670828\u65e5\uff09\u663e\u793a\uff0c\u622a\u6b62\u5230\u68c0\u7d22\u65e5\uff0c\u5168\u7403\u516c\u5f00\u7684\u4e0e\u5965\u8d1d\u80c6\u9178\u76f8\u5173\u7684\u4e13\u5229\u7533\u8bf7\u5171104\u4ef6\uff0c\u5176\u4e2d\u539f\u7814\u516c\u53f8Intercept\u516c\u53f8\u5360\u4e86\u5176\u4e2d\u768421\u4ef6\uff0c\u5360\u6bd4\u4e3a18.9%\uff1b\u65e5\u672c\u4f4f\u53cb\u682a\u5f0f\u4f1a\u793e\u548cWaterstonePharmaceuticals\u4ee54\u4ef6\uff083.6%\uff09\u7684\u7533\u8bf7\u91cf\u5e76\u5217\u6392\u5728\u7b2c\u4e8c\u4f4d\uff0c\u800c\u534e\u4e1c\u5e08\u8303\u5927\u5b66\u4ee53\u4ef6\uff082.7%\uff09\u7684\u7533\u8bf7\u91cf\u6392\u5728\u7b2c\u56db\u4f4d\uff08\u56fe2\uff09\u3002<\/span><br  \/><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"           style=\"width: 100%;height: auto;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/3-1554966026.jpeg\" alt=\"\u809d\u75c5\u836f\u7269\u5965\u8d1d\u80c6\u9178\u4e13\u5229\u5e03\u5c40\u5206\u6790\" title=\"\u809d\u75c5\u836f\u7269\u5965\u8d1d\u80c6\u9178\u4e13\u5229\u5e03\u5c40\u5206\u6790\"  \/><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\"><\/span><\/p>\n<p style=\"text-indent: 2em;text-align: center;\"><span style=\"font-size: 15px;\">\u56fe2\uff1a\u5965\u8d1d\u80c6\u9178\u5404\u7533\u8bf7\u673a\u6784\u5206\u5e03\u60c5\u51b5<\/span><\/p>\n<p style=\"text-indent: 2em;text-align: center;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">2002\u5e74\u516c\u5f00\u4e86\u9996\u4e2a\u5965\u8d1d\u80c6\u9178\u7684PCT\u56fd\u9645\u4e13\u5229\u7533\u8bf7\uff0c2015\u5e74\u4e4b\u524d\uff0c\u5965\u8d1d\u80c6\u9178\u76f8\u5173\u4e13\u5229\u7533\u8bf7\u516c\u5f00\u7684\u603b\u4ef6\u6570\u4ec5\u4e3a13\u4ef6\uff0c\u5965\u8d1d\u80c6\u9178\u4e13\u5229\u7533\u8bf7\u516c\u5f00\u7684\u9ad8\u5cf0\u671f\u51fa\u73b0\u57282016\uff5e2018\u5e74\uff0c2017\u5e74\u8fbe\u5230\u5cf0\u503c\uff0836\u4ef6\uff09\u3002\u5965\u8d1d\u80c6\u9178\u76f8\u5173\u7684\u4e13\u5229\u7533\u8bf7\u5728\u5404\u5e74\u4efd\u516c\u5f00\u60c5\u51b5\u8be6\u89c1\u56fe3\u3002\u5965\u8d1d\u80c6\u9178\u56fd\u5185\u4e13\u5229\u7533\u8bf7\u4e3b\u8981\u96c6\u4e2d\u5728\u6676\u578b\u4e13\u5229\uff0c\u5357\u4eac\u6d4e\u7fa4\u3001\u5929\u6d25\u6c49\u5eb7\u3001\u82cf\u5dde\u6676\u4e91\u3001\u5357\u4eac\u957f\u5965\u3001\u53a6\u95e8\u851a\u626c\u3001\u6210\u90fd\u65b0\u529f\u3001\u6210\u90fd\u767e\u88d5\u3001\u56db\u5ddd\u745e\u897f\u5eb7\u3001\u5e7f\u4e1c\u4e3d\u73e0\u4ee5\u53ca\u6c5f\u82cf\u6052\u745e\u7b49\u5747\u65e0\u6388\u6743\u4e13\u5229\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"          style=\"width: 100%;height: auto;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/2-1554966026.png\" alt=\"\u809d\u75c5\u836f\u7269\u5965\u8d1d\u80c6\u9178\u4e13\u5229\u5e03\u5c40\u5206\u6790\" title=\"\u809d\u75c5\u836f\u7269\u5965\u8d1d\u80c6\u9178\u4e13\u5229\u5e03\u5c40\u5206\u6790\"  \/><\/p>\n<p style=\"text-indent: 2em;text-align: center;\"><span style=\"font-size: 15px;\">\u56fe3\uff1a\u5965\u8d1d\u80c6\u9178\u4e13\u5229\u7533\u8bf7\u516c\u5f00\u5728\u5404\u5e74\u4efd\u5206\u5e03\u60c5\u51b5<\/span><\/p>\n<p style=\"text-indent: 2em;\"><br  \/><\/p>\n<section class=\"_editor\">\n<section style=\"text-align: center;\">\n<section style=\"border-bottom:solid;border-width:1px;border-color:#b0c5ff;display:inline-block;padding:3px 15px;\">\n<p style=\"letter-spacing: 2px;\"><strong><span style=\"color: rgb(0, 128, 255);font-size: 15px;text-align: justify;text-indent: 34px;\">3.Intercept\u516c\u53f8\u5965\u8d1d\u80c6\u9178\u4e13\u5229\u5e03\u5c40<\/span><\/strong><\/p>\n<\/section>\n<section style=\"margin-left: auto;margin-right: auto;margin-top: -5px;transform: rotateZ(45deg);width: 10px;height: 10px;background-color: rgb(176, 197, 255);\"><br  \/><\/section>\n<\/section>\n<\/section>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u4f5c\u4e3a\u4e00\u4e2a\u91cd\u78c5\u70b8\u5f39\u836f\u7269\u7684\u6f5c\u529b\u80a1\uff0c\u6838\u5fc3\u5316\u5408\u7269\u4e13\u5229\u4fdd\u62a4\u5bf9\u672a\u6765\u836f\u7269\u9500\u552e\u989d\u7684\u4fdd\u8bc1\u5341\u5206\u5173\u952e\u3002\u5965\u8d1d\u80c6\u9178\u6700\u65e9\u662f\u7531\u610f\u5927\u5229\u4f69\u9c81\u8d3e\u5927\u5b66\u7684Pellicciari Roberto\u53d1\u73b0\u5e76\u7533\u8bf7\u4e13\u5229\uff0c\u5e76\u4e8e2002\u5e74\u516c\u5f00\u4e86\u9996\u4e2aPCT\u56fd\u9645\u7533\u8bf7\uff08\u56fd\u9645\u516c\u5f00\u53f7WO 02072598A1\uff09\uff0c\u968f\u540e\u9646\u7eed\u5728\u6b27\u7f8e\u65e5\u7b49\u4e3b\u8981\u56fd\u5bb6\u83b7\u5f97\u6388\u6743\uff0c\u5176\u4e2d\u7f8e\u56fd\u4e13\u5229US 7138390B2\u62e5\u6709\u5ef6\u957f\u671f\uff0c\u4fdd\u62a4\u671f\u8f83\u957f\uff0c\u52302022\u5e7411\u670816\u65e5\u3002\u9274\u4e8e\u5728\u5305\u62ec\u4e2d\u65e5\u97e9\u7684\u4e9a\u6d32\u5730\u533a\uff0cIntercept\u516c\u53f8\u5df2\u5c06\u5965\u8d1d\u80c6\u9178\u6388\u6743\u7ed9\u4e86\u65e5\u672c\u4f4f\u53cb\u5236\u836f\uff0c\u5965\u8d1d\u80c6\u9178\u539f\u7814\u516c\u53f8Intercept\u5e76\u672a\u5728\u4e2d\u56fd\u7533\u8bf7\u5965\u8d1d\u80c6\u9178\u5316\u5408\u7269\u6838\u5fc3\u4e13\u5229\uff0c\u4ea6\u5373\u5965\u8d1d\u80c6\u9178\u5316\u5408\u7269\u4e13\u5229\u5e76\u6ca1\u6709\u7533\u8bf7\u8fdb\u5165\u4e2d\u56fd\u3002\u7531Intercept\u516c\u53f8\u7533\u8bf7\u5965\u8d1d\u80c6\u9178\u540e\u7eed\u7684\u5916\u56f4\u4e13\u5229\uff0c\u4e3b\u8981\u5e03\u5c40\u5728\u76d0\/\u6676\u578b\u3001\u9002\u5e94\u75c7\u3001\u884d\u751f\u7269\u548c\u8054\u5408\u7528\u836f\u6280\u672f\u3002\u9664\u6838\u5fc3\u5316\u5408\u7269\u4e13\u5229\u5916\uff0cIntercept\u516c\u53f8\u8fd8\u7533\u8bf7\u4e86\u5965\u8d1d\u80c6\u9178\u5f02\u6784\u4f53\u7ed3\u6784\u5f0f\u4e13\u5229WO 2005082925A2\uff0c\u8be5\u4e13\u5229\u7533\u8bf7\u4f9d\u7136\u6ca1\u6709\u8fdb\u5165\u4e2d\u56fd\u3002Intercept\u516c\u53f8\u516c\u5f00\u7684\u5965\u8d1d\u80c6\u9178\u4e13\u5229\u7533\u8bf7\u89c1\u88681\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-indent: 2em;text-align: center;\"><span style=\"font-size: 15px;\">\u88681\uff1aIntercept\u516c\u53f8\u516c\u5f00\u7684\u5965\u8d1d\u80c6\u9178\u4e13\u5229\u7533\u8bf7<\/span><\/p>\n<p><img class=\"\"          style=\"width: 100%;height: auto;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/4-1554966027.jpg\" alt=\"\u809d\u75c5\u836f\u7269\u5965\u8d1d\u80c6\u9178\u4e13\u5229\u5e03\u5c40\u5206\u6790\" title=\"\u809d\u75c5\u836f\u7269\u5965\u8d1d\u80c6\u9178\u4e13\u5229\u5e03\u5c40\u5206\u6790\"  \/><\/p>\n<p><img class=\"\"          style=\"width: 100%;height: auto;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/1-1554966027.jpg\" alt=\"\u809d\u75c5\u836f\u7269\u5965\u8d1d\u80c6\u9178\u4e13\u5229\u5e03\u5c40\u5206\u6790\" title=\"\u809d\u75c5\u836f\u7269\u5965\u8d1d\u80c6\u9178\u4e13\u5229\u5e03\u5c40\u5206\u6790\"  \/><\/p>\n<p style=\"text-indent: 2em;text-align: center;\"><br  \/><\/p>\n<section class=\"_editor\">\n<section style=\"text-align: center;\">\n<section style=\"border-bottom:solid;border-width:1px;border-color:#b0c5ff;display:inline-block;padding:3px 15px;\">\n<p style=\"letter-spacing: 2px;\"><strong><span style=\"color: rgb(0, 128, 255);font-size: 15px;text-align: justify;text-indent: 34px;\">4.&nbsp;\u5c0f\u7ed3<\/span><\/strong><\/p>\n<\/section>\n<section style=\"margin-left: auto;margin-right: auto;margin-top: -5px;transform: rotateZ(45deg);width: 10px;height: 10px;background-color: rgb(176, 197, 255);\"><br  \/><\/section>\n<\/section>\n<\/section>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u5965\u8d1d\u80c6\u9178\u76ee\u524d\u6b63\u5f00\u53d1\u7528\u4e8e\u591a\u79cd\u6162\u6027\u809d\u810f\u75be\u75c5\u7684\u6cbb\u7597\uff0c\u5305\u62ec\u5df2\u83b7\u6279\u7684PBC\uff08\u4e0a\u5e02\uff09\u3001NASH\uff08\u2162\u671f\u4e34\u5e8a\uff09\u3001PSC\uff08\u2161\u671f\u4e34\u5e8a\uff09\u3001\u80c6\u9053\u95ed\u9501\uff08Biliary atresia\uff0c\u2161\u671f\u4e34\u5e8a\uff09\uff0c\u5176\u4e2dNASH\u4e3a\u5176\u91cd\u70b9\u7814\u53d1\u9002\u5e94\u75c7\u3002\u636eEvaluate Pharma\u9884\u6d4b2020\u5e74\u5965\u8d1d\u80c6\u9178\u5168\u7403\u9500\u91cf\u5c06\u8fbe\u523029.92\u4ebf\u7f8e\u5143\u3002<\/span><br  \/><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u4eca\u5e742\u6708NASH\u6cbb\u7597\u836f\u7269\u7814\u53d1\u53f2\u4e0a\u53d6\u5f97\u5212\u65f6\u4ee3\u7684\u8fdb\u5c55\uff0cIntercept\u516c\u53f8\u7684\u5965\u8d1d\u80c6\u9178\u633a\u8fc7\u4e86\u7b2c\u4e00\u4e2a\u2162\u671f\u4e34\u5e8a\uff08\u56e0\u4e3a\u4fee\u6539\u4e86\u4e34\u5e8a\u7ec8\u70b9\uff09\uff0c\u57fa\u4e8e\u8be5\u79ef\u6781\u7684\u9876\u7ebf\u7ed3\u679c\uff0c\u5965\u8d1d\u80c6\u9178\u6709\u53ef\u80fd\u6210\u4e3a\u6cbb\u7597\u56e0\u4e3aNASH\u51fa\u73b0\u809d\u810f\u7ea4\u7ef4\u5316\u60a3\u8005\u7684\u9996\u6b3e\u83b7\u6279\u4e0a\u5e02\u7597\u6cd5\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u60a3\u8005\u6570\u91cf\u5e9e\u5927\uff0c\u5168\u7403\u60a3\u75c5\u4eba\u6570\u5927\u7ea6\u5360\u5168\u7403\u603b\u4eba\u53e3\u76842%\uff5e3%\uff0c\u76ee\u524d\u5c1a\u65e0\u4efb\u4f55\u6cbb\u7597\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u7684\u836f\u7269\u83b7\u6279\uff0c\u5e02\u573a\u7a7a\u95f4\u5de8\u5927\uff0cNASH\u9884\u671f\u662f\u4e00\u4e2a400\u4ebf\u7f8e\u5143\u7684\u5927\u5e02\u573a\uff0c\u5438\u5f15\u4e86\u5168\u7403\u4f17\u591a\u751f\u7269\u5236\u836f\u516c\u53f8\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u539f\u7814\u516c\u53f8Intercept\u516c\u53f8\u5bf9\u5965\u8d1d\u80c6\u9178\u8fdb\u884c\u4e86\u5168\u9762\u7684\u4e13\u5229\u5e03\u5c40\u3002\u622a\u6b62\u5230\u68c0\u7d22\u65e5\uff0cIntercept\u516c\u53f8\u5171\u516c\u5f00\u5965\u8d1d\u80c6\u9178\u76f8\u5173\u7684\u4e13\u5229\u7533\u8bf721\u4ef6\u30022002\u5e74\u516c\u5f00\u4e86\u9996\u4e2a\u5965\u8d1d\u80c6\u9178\u5316\u5408\u7269\u4e13\u5229\u7684PCT\u56fd\u9645\u7533\u8bf7\uff0c\u5965\u8d1d\u80c6\u9178\u5916\u56f4\u4e13\u5229\u4e3b\u8981\u5e03\u5c40\u5728\u76d0\u3001\u6676\u578b\u3001\u9002\u5e94\u75c7\u3001\u5236\u5907\u65b9\u6cd5\u548c\u884d\u751f\u7269\u8054\u5408\u7528\u836f\u6280\u672f\u3002\u5965\u8d1d\u80c6\u9178\u6838\u5fc3\u5316\u5408\u7269\u4e13\u5229\u5e76\u6ca1\u6709\u7533\u8bf7\u8fdb\u5165\u4e2d\u56fd\u3002<\/span><\/p>\n<p><span style=\"font-size: 12px;color: rgb(136, 136, 136);\"><br  \/><\/span><\/p>\n<p><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">\u3010\u53c2\u8003\u8d44\u6599\u3011&nbsp;&nbsp;&nbsp; <\/span><\/p>\n<p><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">1. Intercept\u516c\u53f8\u5b98\u7f51, www.interceptpharma.com.<\/span><\/p>\n<p><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">2. \u79d1\u777f\u552f\u5b89Clarivate Analytics Integrity\u6570\u636e\u5e93, \u68c0\u7d22\u65e5\u671f: 2019\u5e742\u670828\u65e5.<\/span><\/p>\n<p><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">3. \u4e07\u8c61\u4e91, \u68c0\u7d22\u65e5\u671f: 2018\u5e743\u67081\u65e5.<\/span><\/p>\n<p><br  \/><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08Nonalcoholic steatohepatitis\uff0cNASH\uff09\u662f\u4e00\u4e2a\u5b58\u5728\u5de8\u5927\u672a\u6ee1\u8db3\u9700 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":82372,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/82371"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=82371"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/82371\/revisions"}],"predecessor-version":[{"id":82379,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/82371\/revisions\/82379"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/82372"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=82371"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=82371"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=82371"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}