{"id":82405,"date":"2019-03-05T00:00:50","date_gmt":"2019-04-11T07:00:48","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/82405\/"},"modified":"2019-04-11T15:00:53","modified_gmt":"2019-04-11T07:00:53","slug":"3032e42244","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/82405\/","title":{"rendered":"\u80c3\u764c\u6cbb\u7597\u836f\u7269\u7814\u53d1\u8fdb\u5c55"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p style=\"text-align: left;\">\n<p style=\"text-align: center;\"><br  \/><\/p>\n<p style=\"text-align: center;\"><strong><span style=\"font-size: 18px;color: rgb(2, 30, 170);\">\u80c3\u764c\u7684\u5206<\/span><span style=\"color: rgb(2, 30, 170);font-size: 18px;\">\u578b<\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><strong><span style=\"color: rgb(2, 30, 170);font-size: 18px;\"><br  \/><\/span><\/strong><\/p>\n<p style=\"text-align: left;text-indent: 2em;\"><span style=\"text-align: justify;line-height: 1.6;font-size: 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15px;\">\u7136\u800c\uff0c\u4f20\u7edf\u7684Borrmann\u5206\u578b\u3001Lauren\u5206\u578b\u548cWHO\u5206\u578b\u7b49\u75c5\u7406\u7ec4\u7ec7\u5206\u578b\u5df2\u4e0d\u80fd\u6ee1\u8db3\u4e34\u5e8a\u9700\u6c42\uff0c\u968f\u7740\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u6280\u672f\u3001\u5927\u6570\u636e\u5206\u6790\u4ee5\u53ca\u5176\u4ed6\u7cbe\u51c6\u533b\u5b66\u76f8\u5173\u6280\u672f\u624b\u6bb5\u7684\u53d1\u5c55\uff0c\u80c3\u764c\u5206\u578b\u4e5f\u9010\u6e10\u4ece\u7ec4\u7ec7\u5b66\u5206\u578b\u5411\u5206\u5b50\u5206\u578b\u8f6c\u53d8\u30022014\u5e74\uff0c\u4eba\u7c7b\u764c\u75c7\u57fa\u56e0\u7ec4\u56fe\u8c31\uff08The Cancer Genome 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style=\"text-indent: 2em;\"><br  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 18px;\"><strong><span style=\"color: rgb(2, 30, 170);\">\u80c3\u764c\u6cbb\u7597\u9776\u70b9<\/span><\/strong><\/span><\/p>\n<p><strong><span style=\"color: rgb(2, 30, 170);\"><br  \/><\/span><\/strong><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u81ea\u4ece\u66f2\u59a5\u73e0\u5355\u6297\u88ab\u786e\u7acb\u4e3aHER2\u9633\u6027\u4e0d\u53ef\u5207\u9664\u80c3\u764c\u7684\u6807\u51c6\u7597\u6cd5\u540e\uff0c\u4e00\u4e9b\u65b0\u7684\u764c\u75c7\u6cbb\u7597\u9776\u6807\u88ab\u9646\u7eed\u53d1\u73b0\u3002\u76ee\u524d\u80c3\u764c\u7684\u9776\u5411\u6cbb\u7597\u6839\u636e\u4e0d\u540c\u7684\u9776\u70b9\u4e3b\u8981\u53ef\u5206\u4e3a\u4ee5\u4e0b\u51e0\u7c7b\uff1a\u6297\u4eba\u7c7b\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f531\uff08EGFR1\uff09\u3001\u6297HER-2\u3001\u6297\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09\u3001\u6297VEGFR\u3001\u6297\u54fa\u4e73\u52a8\u7269\u96f7\u5e15\u9709\u7d20\u9776\u86cb\u767d\uff08mTOR\uff09\u3001\u6297\u91cd\u7ec4\u4eba\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08FGFR2\uff09\u3001\u6297\u809d\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u53d7\u4f53\uff08HGFR\/c-MET\uff09\u3001\u6297\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u914d\u4f53-1\uff08PD-L1\uff09\u3001\u6297\u7ec6\u80de\u6bd2T\u6dcb\u5df4\u7ec6\u80de\u76f8\u5173\u6297\u539f4\uff08CTLA-4\uff09\u3001\u6297\u4e24\u9762\u795e\u6fc0\u9176\uff08JAK2\uff09\u3001\u6297\u805a\u817a\u82f7\u9178\u4e8c\u78f7\u9178\u6838\u7cd6\u8f6c\u79fb\u9176-1\uff08PARP-1\uff09\u3001\u6297Claudin 18.2\uff08CLDN18.2\uff09\u7b49\u3002\u56fe1\u5217\u51fa\u4e86\u80c3\u764c\u90e8\u5206\u81f4\u764c\u9014\u5f84\u548c\u6f5c\u5728\u7684\u9776\u5411\u836f\u7269\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/10-1554966049.jpg\" alt=\"\u80c3\u764c\u6cbb\u7597\u836f\u7269\u7814\u53d1\u8fdb\u5c55\" title=\"\u80c3\u764c\u6cbb\u7597\u836f\u7269\u7814\u53d1\u8fdb\u5c55\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\">\u56fe1\uff1a\u80c3\u764c\u7684\u9776\u5411\u7597\u6cd5\u548c\u81f4\u764c\u901a\u8def<\/span><\/p>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<p style=\"text-align: left;text-indent: 2em;\"><span style=\"font-size: 15px;line-height: 24px;text-indent: 34px;\">\u56fe2\u5217\u51fa\u4e86\u80c3\u764c\u5728\u514d\u75ab\u6cbb\u7597\u9886\u57df\u76f8\u5173\u7684\u9776\u70b9\u548c\u6f5c\u5728\u7684\u6cbb\u7597\u836f\u7269\u3002<\/span><\/p>\n<p style=\"text-align: left;text-indent: 2em;\"><span style=\"font-size: 15px;line-height: 24px;text-indent: 34px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/9-1554966049.jpeg\" alt=\"\u80c3\u764c\u6cbb\u7597\u836f\u7269\u7814\u53d1\u8fdb\u5c55\" title=\"\u80c3\u764c\u6cbb\u7597\u836f\u7269\u7814\u53d1\u8fdb\u5c55\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\">\u56fe2\uff1a\u80c3\u764c\u4e2d\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242<\/span><\/p>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u80c3\u764c\u9886\u57df\u6cbb\u7597\u836f\u7269\u9776\u6807\u5168\u666f\u5982\u56fe3~4\u6240\u793a\uff1a\u56fe\u4e2d\u663e\u793a\u4e86\u7ec6\u80de\u548c\u5206\u5b50\u6c34\u5e73\u7684\u80c3\u764c\u836f\u7269\u9776\u70b9\u603b\u4f53\u60c5\u51b5\uff08\u6765\u6e90\uff1aIntegrity\u6570\u636e\u5e93\uff09\u3002\u7bad\u5934\u4ee3\u8868\u6b63\u6548\u5e94\uff0c\u7834\u6298\u53f7\u8868\u793a\u8d1f\u6548\u5e94\uff1b\u7070\u8272\u6216\u6d45\u8272\u6807\u8bb0\u7684\u662f\u672a\u7ecf\u8bc1\u5b9e\u7684\u9776\u70b9\uff1b\u5e26\u6709\u7ea2\u8272\u8fb9\u6846\u7684\u7c89\u8272\u6587\u672c\u6846\u6807\u8bb0\u7684\u662f\u5df2\u7ecf\u9a8c\u8bc1\u7684\u57fa\u56e0\u9776\u6807\uff1b\u9ec4\u8272\u6587\u672c\u6846\u662f\u57fa\u56e0\u9776\u6807\u4f46\u662f\u7814\u7a76\u5e76\u4e0d\u6d3b\u8dc3\u3002\u7d2b\u8272\u548c\u7c89\u8272\u6587\u672c\u6846\u5206\u522b\u4ee3\u8868\u7ec6\u80de\u5916\u548c\u7ec6\u80de\u5185\u6548\u5e94\uff1b\u7eff\u8272\u6587\u672c\u6846\u4ee3\u8868\u76f8\u5173\u75be\u75c5\u6216\u9002\u5e94\u75c7\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/8-1554966050.jpeg\" alt=\"\u80c3\u764c\u6cbb\u7597\u836f\u7269\u7814\u53d1\u8fdb\u5c55\" title=\"\u80c3\u764c\u6cbb\u7597\u836f\u7269\u7814\u53d1\u8fdb\u5c55\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\">\u56fe3\uff1a\u80c3\uff08\u817a\uff09\u764c\u6cbb\u7597\u836f\u7269\u9776\u6807\u5168\u666f\u56fe<\/span><\/p>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/5-1554966050.jpeg\" alt=\"\u80c3\u764c\u6cbb\u7597\u836f\u7269\u7814\u53d1\u8fdb\u5c55\" title=\"\u80c3\u764c\u6cbb\u7597\u836f\u7269\u7814\u53d1\u8fdb\u5c55\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\">\u56fe4\uff1a\u80c3\u80a0\u95f4\u8d28\u7624\u6cbb\u7597\u836f\u7269\u9776\u6807\u5168\u666f\u56fe<\/span><\/p>\n<p><br  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"color: rgb(2, 30, 170);font-size: 18px;\"><strong>\u80c3\u764c\u4e0a\u5e02\u836f\u7269<\/strong><\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u636eIntegrity\u6570\u636e\u5e93\uff08\u68c0\u7d22\u65e5\u671f\uff1a2019\u5e742\u670822\u65e5\uff09\uff0c\u5e38\u7528\u7684\u80c3\u764c\u6cbb\u7597\u836f\u7269\u6709\uff1a\u591a\u897f\u4ed6\u8d5b\u30015-\u6c1f\u5c3f\u5627\u5576\u3001\u987a\u94c2\u3001\u963f\u9709\u7d20\u3001\u4e1d\u88c2\u9709\u7d20\u3001\u66f2\u59a5\u73e0\u5355\u6297\u3001\u96f7\u83ab\u82a6\u5355\u6297\u3001\u7eb3\u6b66\u5355\u6297\u548c\u6d3e\u59c6\u5355\u6297\u7b49\uff0c\u9664\u6b64\u4e4b\u5916\uff0c\u8fd8\u6709\u6211\u56fd\u56fd\u5185\u4e0a\u5e02\u7684\u963f\u5e15\u66ff\u5c3c\uff0c\u80c3\u764c\u76f8\u5173\u6cbb\u7597\u836f\u7269\u8fd8\u5728\u4e0d\u65ad\u7684\u7814\u53d1\u5f53\u4e2d\uff0c\u88681~2\u4e3a\u90e8\u5206\u6cbb\u7597\u80c3\uff08\u817a\uff09\u764c\u548c\u80c3\u80a0\u95f4\u8d28\u7624\u7684\u4ee3\u8868\u6027\u4e0a\u5e02\u836f\u7269\u548c\u6cbb\u7597\u65b9\u6cd5\u3002<\/span><\/p>\n<p><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 16px;\"><strong><span style=\"color: rgb(255, 76, 65);\">\u66f2\u59a5\u73e0\u5355\u6297<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\"><strong><span style=\"color: rgb(255, 76, 65);\"><br  \/><\/span><\/strong><\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u66f2\u59a5\u73e0\u5355\u6297\u662f\u4e00\u79cd\u7279\u5f02\u6027\u9488\u5bf9HER2\u80de\u5916\u533a\u7684\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\uff0c\u901a\u8fc7\u62ee\u6297HER2\u4fe1\u53f7\u4f20\u5bfc\u800c\u6291\u5236\u80bf\u7624\u7ec6\u80de\u7684\u751f\u957f\u4e0e\u589e\u6b96\uff0c\u6709\u7814\u7a76\u62a5\u9053\uff0cHER-2\u5728\u80c3\u764c\u4e2d\u7684\u8868\u8fbe\u7387\u9ad8\uff0c\u4e3a6%~45%\u3002\u6839\u636e\u4e34\u5e8a\u76d1\u6d4b\uff0c\u66f2\u59a5\u73e0\u5355\u6297\u5177\u6709\u4e00\u5b9a\u7684\u5fc3\u810f\u6bd2\u6027\u4f5c\u7528\u3002\u66f2\u59a5\u73e0\u5355\u6297\u4f5c\u4e3a\u4e00\u7ebf\u6cbb\u7597\u5728\u665a\u671f\u80c3\u764c\u4e2d\u7684\u5e73\u5747\u6709\u6548\u65f6\u95f4\u4ec5\u4e00\u5e74\uff0c\u5176\u8054\u5408\u7528\u7a76\u76ee\u524d\u4f9d\u7136\u5728\u4e0d\u65ad\u7684\u63a2\u7d22\u4e2d\u3002ToGA\u7814\u7a76\u4f5c\u4e3a\u7b2c\u4e00\u9879\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597HER2\u9633\u6027\u80c3\u764c\u7684\u5927\u578b\u2162\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u9996\u6b21\u8bc1\u5b9e\u5316\u7597\u8054\u5408\u9776\u5411\u836f\u7269\u53ef\u663e\u7740\u5ef6\u957f\u665a\u671f\u80c3\u764c\u7684\u603b\u751f\u5b58\u671f\u3002\u7814\u7a76\u8bc1\u660e\uff0c\u66f2\u59a5\u73e0\u5355\u6297\u8054\u5408\u6c1f\u5c3f\u5627\u5576\u7c7b\u836f\u7269\u4e3a\u57fa\u7840\u7684\u5316\u7597\uff0c\u6cbb\u7597HER2\u9633\u6027\u665a\u671f\u80c3\u764c\u7684\u7597\u6548\u8981\u663e\u8457\u4f18\u4e8e\u5355\u7eaf\u5316\u7597\uff0c\u4e14\u5b89\u5168\u6027\u826f\u597d\uff0c\u53ef\u663e\u8457\u5ef6\u957f\u665a\u671f\u80c3\u764c\u60a3\u8005\u7684OS\u3002\u6b64\u5916\uff0c\u66f2\u59a5\u73e0\u5355\u6297\u6cbb\u7597\u4e2d\u56fdHER2\u9633\u6027\u8f6c\u79fb\u6027\u80c3\u764c\u60a3\u8005\u7684\u4e2d\u4f4dOS\u9ad8\u8fbe30\u4e2a\u6708\uff0c\u4e2d\u4f4dPFS\u4e3a9.5\u4e2a\u6708\u3002<\/span><\/p>\n<p><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"color: rgb(255, 76, 65);font-size: 16px;\"><strong>\u7532\u78fa\u9178\u963f\u5e15\u66ff\u5c3c<\/strong><\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"color: rgb(255, 76, 65);font-size: 15px;\"><strong><br  \/><\/strong><\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u7532\u78fa\u9178\u963f\u5e15\u66ff\u5c3c\u662f\u4e00\u79cd\u53e3\u670d\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff0c\u9009\u62e9\u6027\u5730\u6291\u5236VEGFR-2\uff0c\u963b\u65ad\u5176\u4e0b\u6e38\u4fe1\u53f7\u4f20\u5bfc\uff0c\u6291\u5236\u80bf\u7624\u8840\u7ba1\u751f\u6210\u30022014\u5e7410\u6708\uff0c\u963f\u5e15\u66ff\u5c3c\u83b7CFDA\u6279\u51c6\u4e0a\u5e02\uff0c\u6210\u4e3a\u4e0d\u53ef\u5207\u9664\u7684\u665a\u671f\u80c3\u764c\u7684\u4e09\u7ebf\u7528\u836f\uff0c\u963f\u5e15\u66ff\u5c3c\u4e0e\u5b89\u6170\u5242\u5bf9\u6bd4\u53ef\u663e\u8457\u6539\u5584\u60a3\u8005\u7684\u4e2d\u4f4dOS\uff086.5\u4e2a\u6708vs.4.7\u4e2a\u6708\uff09\u548c\u4e2d\u4f4dPFS\uff082.6\u4e2a\u6708vs.1.8\u4e2a\u6708\uff09\u30022018\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5927\u4f1a\u4e0a\u6052\u745e\u516c\u53f8\u8fd8\u516c\u5e03\u4e86\u963f\u5e15\u66ff\u5c3c\u8054\u5408\u5316\u7597\u836f\u7269\u591a\u897f\u4ed6\u8d5b\u4e8c\u7ebf\u6cbb\u7597\u665a\u671f\u80c3\u764c\u7684\u7814\u7a76\u7ed3\u679c\uff0c\u521d\u671f\u8bc4\u4ef7\u6709\u6548\u7387\u4e3a23%\u3002\u963f\u5e15\u66ff\u5c3c\u8054\u5408\u514d\u75ab\u7597\u6cd5\u6cbb\u7597\u80c3\u764c\u7684\u7814\u53d1\u4e5f\u5728\u8fdb\u884c\u4e2d\uff0c\u91c7\u7528\u6052\u745e\u7684PD1\u5355\u6297\u8054\u5408\u963f\u5e15\u66ff\u5c3c\u6cbb\u7597\u6807\u51c6\u6cbb\u7597\u5931\u8d25\u7684\u665a\u671f\u80c3\u764c\u53ca\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u80bf\u7624\u3002\u7ed3\u679c\u663e\u793a\uff1a\u80c3\u764c\u60a3\u8005\u7684\u6709\u6548\u7387\u4e3a13.6%\uff0c\u75be\u75c5\u63a7\u5236\u7387\u5f88\u9ad8\uff0c\u8fbe\u523077.3%\u3002<\/span><\/p>\n<p><strong><span style=\"color: rgb(255, 76, 65);font-size: 18px;\"><br  \/><\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 16px;\"><strong><span style=\"color: rgb(255, 76, 65);\">\u6d3e\u59c6\u5355\u6297<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\"><strong><span style=\"color: rgb(255, 76, 65);\"><br  \/><\/span><\/strong><\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">2017\u5e749\u6708\uff0cFDA\u52a0\u901f\u6279\u51c6\u4e86\u6d3e\u59c6\u5355\u6297\u6cbb\u7597\u590d\u53d1\u6027\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80c3\u764c\u6216\u80c3\u98df\u7ba1\u4ea4\u754c\u90e8\u817a\u764c\u60a3\u8005\uff0c\u6210\u4e3aFDA\u6709\u53f2\u4ee5\u6765\u9996\u4e2a\u6279\u51c6\u7684\u80c3\u764c\u514d\u75ab\u6cbb\u7597\u836f\u7269\uff0c\u6b64\u6b21\u6279\u51c6\u662f\u57fa\u4e8eKEYNOTE 059\u7814\u7a76\uff08NCT02335411\uff09\u7ed3\u679c\u3002\u6b64\u5916\uff0cFDA\u8fd8\u6279\u51c6\u4e86\u76f8\u5e94\u7684\u68c0\u6d4b\u8bd5\u5242\u76d2PD-L1 IHC 22C3 pharmDx\uff08Dako\uff09\u3002KEYNOTE 059\u7814\u7a76\u8bd5\u9a8c\u5165\u7ec4\u4e86259\u4f8b\u80c3\u764c\u6216\u98df\u7ba1\u80c3\u4ea4\u754c\u90e8\u817a\u764c\u60a3\u8005\u3002\u5728259\u4f8b\u60a3\u8005\u4e2d\uff0c55%\uff08n=143\uff09\u7684\u60a3\u8005\u80bf\u7624\u8868\u8fbePD-L1\uff0c\u5e76\u6709\u5fae\u536b\u661f\u7a33\u5b9a\uff08MSS\uff09\u6216\u672a\u786e\u5b9a\u5fae\u536b\u661f\u4e0d\u7a33\u5b9a\uff08MSI\uff09\u6216\u9519\u914d\u4fee\u590d\uff08MMR\uff09\u72b6\u6001\u3002\u5bf9\u4e8e143\u4f8b\u80bf\u7624\u8868\u8fbePD-L1\u7684\u60a3\u8005\u53ca\u6709MSS\u6216MSI\u6216\u9519\u914d\u4fee\u590d\u7f3a\u9677\uff08dMMR\uff09\u72b6\u6001\u7684\u60a3\u8005\uff0c\u5176\u5ba2\u89c2\u7f13\u89e3\u7387\u4e3a13.3%\uff0c\u5176\u4e2d1.4%\u7684\u60a3\u8005\u83b7\u5f97\u5b8c\u5168\u7f13\u89e3\uff0c11.9%\u7684\u60a3\u8005\u83b7\u5f97\u90e8\u5206\u7f13\u89e3\u3002\u572819\u4f8b\u7f13\u89e3\u60a3\u8005\u4e2d\uff0c\u6301\u7eed\u7f13\u89e3\u65f6\u95f4\u4ece2.8+\u523019.4+\u4e2a\u6708\u4e0d\u7b49\uff0c\u5176\u4e2d11\u4f8b\u60a3\u8005\uff0858%\uff09\u7684\u6301\u7eed\u7f13\u89e3\u65f6\u95f4\u4e3a6\u4e2a\u6708\u6216\u66f4\u957f\uff0c5\u4f8b\u60a3\u8005\uff0826%\uff09\u7684\u6301\u7eed\u7f13\u89e3\u65f6\u95f4\u4e3a12\u4e2a\u6708\u6216\u66f4\u957f\u3002<\/span><\/p>\n<p><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\">\u88681\uff1a\u5df2\u4e0a\u5e02\u7528\u4e8e\u80c3\uff08\u817a\uff09\u764c\u6cbb\u7597\u7684\u4ee3\u8868\u6027\u836f\u7269<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/8-1554966051.jpeg\" alt=\"\u80c3\u764c\u6cbb\u7597\u836f\u7269\u7814\u53d1\u8fdb\u5c55\" title=\"\u80c3\u764c\u6cbb\u7597\u836f\u7269\u7814\u53d1\u8fdb\u5c55\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-family: \u5b8b\u4f53;font-size: 14px;line-height: 16px;text-align: -webkit-center;text-indent: 28px;background-color: rgb(255, 255, 255);\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 15px;\">\u88682\uff1a\u5df2\u4e0a\u5e02\u7528\u4e8e\u6cbb\u7597\u80c3\u80a0\u9053\u95f4\u8d28\u7624\u7684\u836f\u7269<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/2-1554966051.jpeg\" alt=\"\u80c3\u764c\u6cbb\u7597\u836f\u7269\u7814\u53d1\u8fdb\u5c55\" title=\"\u80c3\u764c\u6cbb\u7597\u836f\u7269\u7814\u53d1\u8fdb\u5c55\"  \/><\/p>\n<p style=\"text-align: center;\"><br  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 18px;\"><strong><span style=\"color: rgb(2, 30, 170);\">\u80c3\u764c\u5728\u7814\u836f\u7269<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 18px;\"><strong><span style=\"color: rgb(2, 30, 170);\"><br  \/><\/span><\/strong><\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u76ee\u524d\uff0c\u80c3\u764c\u7684\u5728\u7814\u836f\u7269\u4e3b\u8981\u4e3a\u9776\u5411\u836f\u7269\uff0c\u800c\u8fd9\u4e9b\u836f\u7269\u7684\u7814\u53d1\u6210\u529f\u7387\u5e76\u4e0d\u9ad8\uff0c\u636eInforma Biomedtracker\u6570\u636e\u5e93\u9884\u6d4b\uff0c\u9488\u5bf9\u80c3\u764c\u8fdb\u5165\u4e34\u5e8a\u2160\u671f\u7814\u53d1\u9636\u6bb5\u7684\u836f\u7269\u7814\u53d1\u6210\u529f\u7387\u4e3a6%\uff0c\u4e34\u5e8a\u2161\u671f\u4e3a10%\uff0c\u4e34\u5e8a\u2162\u671f\u4e3a35%\uff0cNDA\/BLA\u9636\u6bb5\u4e3a82%\u3002\u88683~4\u5206\u522b\u5217\u51fa\u4e86\u76ee\u524d\u5904\u4e8e\u4e34\u5e8a\u2162\u671f\u53ca\u4ee5\u4e0a\u7684\u80c3\uff08\u817a\uff09\u764c\u548c\u80c3\u80a0\u9053\u95f4\u8d28\u7624\u7684\u5728\u7814\u836f\u7269\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 16px;\"><strong><span style=\"color: rgb(255, 169, 0);\">Trifluridine\/TPI<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: center;\"><strong><span style=\"font-size: 15px;color: rgb(255, 169, 0);\"><br  \/><\/span><\/strong><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">2019\u5e742\u6708\uff0c\u65e5\u672c\u5927\u9e4f\u5236\u836f\u7f8e\u56fd\u5b50\u516c\u53f8Taiho Oncology\u5ba3\u5e03\uff0cFDA\u5df2\u6279\u51c6Lonsurf\uff08trifluridine\/TPI\uff0cTAS-102\uff09\u7528\u4e8e\u65e2\u5f80\u5df2\u63a5\u53d7\u81f3\u5c112\u79cd\u5316\u7597\u65b9\u6848\u7684\u8f6c\u79fb\u6027\u80c3\u6216\u80c3\u98df\u7ba1\u4ea4\u754c\u817a\u764c\u6210\u4eba\u60a3\u8005\u7684\u6cbb\u7597\u3002\u6b64\u6b21\u6279\u51c6\uff0c\u6269\u5927\u4e86Lonsurf\u5728\u7f8e\u56fd\u7684\u9002\u5e94\u75c7\uff0c\u8be5\u836f\u4e4b\u524d\u5df2\u83b7\u6279\u7528\u4e8e\u65e2\u5f80\u5df2\u63a5\u53d7\u6807\u51c6\u5316\u7597\u7684\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u3002Lonsurf\u662f\u4e00\u79cd\u65b0\u578b\u53e3\u670d\u6297\u4ee3\u8c22\u590d\u65b9\u836f\u7269\uff0c\u7531\u6297\u80bf\u7624\u6838\u82f7\u7c7b\u4f3c\u7269FTD\uff08\u4e09\u6c1f\u80f8\u82f7\uff0ctrifluridine\uff09\u548c\u80f8\u82f7\u78f7\u9178\u5316\u9176\u6291\u5236\u5242TPI\uff08tipiracil\uff09\u7ec4\u6210\u3002FDA\u901a\u8fc7\u4f18\u5148\u5ba1\u67e5\u9879\u76ee\u5bf9Lonsurf\u8fdb\u884c\u4e86\u6279\u51c6\uff0c\u6b64\u6b21\u6279\u51c6\u57fa\u4e8e\u4e00\u9879\u5168\u7403\u6027\u3001\u968f\u673a\u2162\u671f\u4e34\u5e8a\u7814\u7a76TAGS\u7684\u6570\u636e\u3002\u8be5\u7814\u7a76\u5728\u65e2\u5f80\u63a5\u53d7\u6807\u51c6\u7597\u6cd5\u6cbb\u7597\u540e\u75c5\u60c5\u8fdb\u5c55\u6216\u5bf9\u6807\u51c6\u7597\u6cd5\u4e0d\u8010\u53d7\u7684\u7ecf\u6cbb\u665a\u671f\u80c3\u764c\u6216\u80c3\u98df\u7ba1\u4ea4\u754c\u817a\u764c\u60a3\u8005\u4e2d\u5f00\u5c55\uff0c\u8bc4\u4f30\u4e86Lonsurf\u8054\u5408\u6700\u4f73\u652f\u6301\u7597\u6cd5\uff08BSC\uff09\u65b9\u6848\u76f8\u5bf9\u4e8e\u5b89\u6170\u5242\u8054\u5408BSC\u65b9\u6848\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u7ed3\u679c\u663e\u793a\uff0c\u8be5\u7814\u7a76\u8fbe\u5230\u4e86\u4e3b\u8981\u7ec8\u70b9\u548c\u6b21\u8981\u7ec8\u70b9\uff1a\u5728\u6574\u4e2a\u7814\u7a76\u7fa4\u4f53\u4e2d\uff0c\u4e0e\u5b89\u6170\u5242+BSC\u65b9\u6848\u76f8\u6bd4\uff0cLonsurf+BSC\u65b9\u6848\u4f7f\u603b\u751f\u5b58\u671f\u5b9e\u73b0\u4e86\u4e34\u5e8a\u610f\u4e49\u548c\u7edf\u8ba1\u5b66\u610f\u4e49\u7684\u6539\u5584\u3001\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e8631%\u3001\u4e2d\u4f4dOS\u5ef6\u957f\u4e862.1\u4e2a\u6708\uff085.7\u4e2a\u6708vs.3.6\u4e2a\u6708\uff09\uff0c\u5e76\u4e14\u5b89\u5168\u6027\u4e0eLonsurf\u7684\u7528\u836f\u7ecf\u9a8c\u4e00\u81f4\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-indent: 0em;text-align: center;\"><span style=\"color: rgb(255, 169, 0);font-size: 16px;\"><strong>Andecaliximab\uff08GS-5745\uff09<\/strong><\/span><\/p>\n<p style=\"text-indent: 0em;text-align: center;\"><span style=\"color: rgb(255, 169, 0);\"><strong><span style=\"font-size: 15px;\"><br  \/><\/span><\/strong><\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">Andecaliximab\uff08GS-5745\uff09\u662f\u5409\u5229\u5fb7\u516c\u53f8\u7814\u53d1\u7684\u9488\u5bf9\u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u91769\uff08MMP-9\uff09\u7684\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\u30022015\u5e74\uff0cAndecaliximab\u88abFDA\u8ba4\u8bc1\u4e3a\u6cbb\u7597\u80c3\u764c\u7684\u5b64\u513f\u836f\u3002\u76ee\u524d\u8be5\u836f\u5728\u8fdb\u884c\u8054\u5408mFOLFOX6\u5316\u7597\u65b9\u6848\u4e00\u7ebf\u6cbb\u7597\u665a\u671f\u80c3\u6216\u80c3\u98df\u7ba1\u4ea4\u754c\u5904\u817a\u764c\u7684\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u30022019\u5e741\u6708\u53ec\u5f00\u7684\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u80c3\u80a0\u9053\u80bf\u7624\u7814\u8ba8\u4f1a\uff08ASCO GI\uff09\uff0c\u516c\u5e03\u4e86Andecaliximab\u8054\u5408mFOLFOX6\u65b9\u6848\u7684\u2162\u671f\u7814\u7a76\u7ed3\u679c\uff0c\u8be5\u7814\u7a76\u7eb3\u5165432\u4f8b\u672a\u7ecf\u6cbb\u7684HER2\u9634\u6027\u80c3\u764c\u6216\u80c3\u98df\u7ba1\u4ea4\u754c\u5904\u817a\u817a\u764c\u60a3\u8005\uff0c\u6bd4\u8f83mFOLFOX6\u52a0\u7528\u6216\u4e0d\u52a0\u7528Andecaliximab\u7684\u7597\u6548\u3002\u7ed3\u679c\u663e\u793a\uff0c\u52a0\u7528\u548c\u672a\u52a0\u7528Andecaliximab\u7ec4\u7684\u4e2d\u4f4dPFS\u5206\u522b\u4e3a7.5\u4e2a\u6708\u548c7.1\u4e2a\u6708\uff0c\u867d\u7136\u6709\u83b7\u76ca\u7684\u8d8b\u52bf\uff0c\u4f46\u6ca1\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\uff1b\u4e24\u7ec4\u4e2d\u4f4dOS\u5206\u522b\u4e3a12.5\u4e2a\u6708\u548c11.8\u4e2a\u6708\u3002\u4e0d\u8fc7\u63a2\u7d22\u6027\u5206\u6790\u7ed3\u679c\u8868\u660e\uff0c\u52a0\u7528Andecaliximab\u53ef\u6539\u5584\u8001\u5e74\u60a3\u8005\u7684\u7ed3\u679c\u3002\u5728\u226565\u5c81\u7684\u4e9a\u7ec4\u4e2d\uff0c\u52a0\u7528\u548c\u672a\u52a0\u7528Andecaliximab\u60a3\u8005\u7684\u4e2d\u4f4dPFS\u5206\u522b\u4e3a13.9\u4e2a\u6708\u548c10.5\u4e2a\u6708\uff1b\u4e2d\u4f4dOS\u5206\u522b\u4e3a13.9\u4e2a\u6708\u548c10.5\u4e2a\u6708\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-indent: 0em;text-align: center;\"><span style=\"color: rgb(255, 169, 0);font-size: 16px;\"><strong>Avelumab<\/strong><\/span><\/p>\n<p style=\"text-indent: 0em;text-align: center;\"><span style=\"color: rgb(255, 169, 0);\"><strong><span style=\"font-size: 15px;\"><br  \/><\/span><\/strong><\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">Avelumab\u662f\u4e00\u79cd\u9776\u5411\u4e8e\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u914d\u4f53\uff08PD-L1\uff09\u7684\u5168\u4eba\u6e90IgG1\u03bb\u578b\u5355\u514b\u9686\u6297\u4f53\uff0c\u80fd\u7ed3\u5408PD-L1\u5e76\u963b\u6b62\u5176\u4e0e\u53d7\u4f53PD-1\u548cB7.1\u7684\u7ed3\u5408\u3002\u8be5\u836f\u83b7FDA\u6279\u51c6\u7528\u4e8e\u6cbb\u7597Merkel\u7ec6\u80de\u764c\uff08\u6210\u4eba\u621612\u5c81\u4ee5\u4e0a\u513f\u7ae5\uff09\u548c\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5c3f\u8def\u4e0a\u76ae\u764c\u3002Avelumab\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80c3\u53ca\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u817a\u764c\u7684\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u800cAvelumab\u4e09\u7ebf\u6cbb\u7597\u65e0\u6cd5\u5207\u9664\u3001\u590d\u53d1\u6216\u8f6c\u79fb\u7684\u80c3\u764c\u6216\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u817a\u764c\u60a3\u8005\uff08\u4e24\u79cd\u6cbb\u7597\u65b9\u6848\u540e\u75c5\u60c5\u8fdb\u5c55\u7684\uff09\u7684\u2162\u671f\u4e34\u5e8a\uff08JAVELIN Gastric 300\uff09\u672a\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\uff0c\u5355\u72ec\u4f7f\u7528avelumab\u4e09\u7ebf\u6cbb\u7597\u80c3\u764c\u76f8\u6bd4\u5316\u7597\u836f\u7269\u4e0d\u80fd\u663e\u8457\u6539\u5584\u60a3\u8005\u7684OS\u3002JAVELIN Gastric 300\u662f\u5168\u7403\u7b2c\u4e00\u9879\u5728\u8fd9\u7c7b\u60a3\u8005\u4e2d\u5f00\u5c55\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u4e0e\u9633\u6027\u836f\u5bf9\u7167\u800c\u975e\u4e0e\u5b89\u6170\u5242\u5bf9\u7167\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u53ef\u4ee5\u4e3a\u76ee\u524d\u7684\u4e34\u5e8a\u6cbb\u7597\u63d0\u4f9b\u53c2\u8003\u4e0e\u4e00\u5b9a\u4f9d\u636e\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-indent: 0em;text-align: center;\"><span style=\"font-size: 16px;\"><strong><span style=\"color: rgb(255, 169, 0);\">Fruquintinib<\/span><\/strong><\/span><\/p>\n<p style=\"text-indent: 0em;text-align: center;\"><strong><span style=\"color: rgb(255, 169, 0);\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/span><\/strong><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u544b\u55b9\u66ff\u5c3c\u662f\u7531\u548c\u8bb0\u9ec4\u57d4\u7814\u53d1\u7684\u4e00\u79cd\u9ad8\u9009\u62e9\u6027\u7684VEGFR\u53e3\u670d\u6291\u5236\u5242\uff0c\u5e76\u4e14\u6709\u6f5c\u529b\u6210\u4e3a\u5168\u7403\u540c\u7c7b\u6700\u4f73\u7684\u80fd\u591f\u6cbb\u7597\u591a\u79cd\u5b9e\u4f53\u7624\u7684VEGFR\u6291\u5236\u5242\u30022018\u5e749\u6708\uff0cNMPA\u6279\u51c6\u544b\u55b9\u66ff\u5c3c\u5728\u4e2d\u56fd\u4e0a\u5e02\uff0c\u7528\u4e8e\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u7684\u6cbb\u7597\u3002\u544b\u55b9\u66ff\u5c3c\u8054\u5408\u7d2b\u6749\u9187\u6cbb\u7597\u4e00\u7ebf\u5316\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u7684\u80c3\u6216\u80c3\u98df\u7ba1\u4ea4\u754c\u5904\u764c\u7684\u2162\u671f\u4e34\u5e8a\u6b63\u5728\u8fdb\u884c\u4e2d\u3002\u5148\u524d\u2160\/\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u544b\u55b9\u66ff\u5c3c\u8054\u5408\u7d2b\u6749\u9187\u53ef\u6709\u6548\u5ef6\u957f\u80c3\u764c\u60a3\u8005\u7684\u4e2d\u4f4dPFS\u3002<\/span><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-indent: 0em;text-align: center;\"><span style=\"font-size: 16px;\"><strong><span style=\"color: rgb(255, 169, 0);\">Pamiparib<\/span><\/strong><\/span><\/p>\n<p style=\"text-indent: 0em;text-align: center;\"><strong><span style=\"font-size: 15px;color: rgb(255, 169, 0);\"><br  \/><\/span><\/strong><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">Pamiparib\u662f\u4e00\u79cd\u5f3a\u6548\u9ad8\u9009\u62e9\u6027\u7684PARP 1\/2\u6291\u5236\u5242\uff0c\u5177\u6709\u826f\u597d\u7684\u836f\u7269\u4ee3\u8c22\u548c\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u6027\uff0c\u76ee\u524d\u6b63\u4f5c\u4e3a\u5355\u4e00\u7597\u6cd5\u6216\u4e0e\u5176\u4ed6\u836f\u7269\u8054\u7528\u6cbb\u7597\u591a\u79cd\u6076\u6027\u5b9e\u4f53\u7624\uff08\u5375\u5de2\u764c\u3001\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u3001\u665a\u671f\u80c3\u7624\u7b49\uff09\u8fdb\u884c\u5168\u7403\u4e34\u5e8a\u5f00\u53d1\uff0c\u800c\u5bf9\u5375\u5de2\u764c\u3001\u665a\u671f\u6216\u8f6c\u79fb\u6027\u80c3\u764c\uff0c\u5df2\u5904\u4e8e\u4e34\u5e8a\u2162\u671f\u9636\u6bb5\u30022018\u5e742\u6708\uff0c\u4e00\u9879\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\uff0c\u968f\u673a\u5316\u7684\u5168\u7403\u591a\u4e2d\u5fc3\u4e34\u5e8a\u2162\u671f\u7814\u7a76\uff08NCT03427814\u3001BGB-290-303\u3001EUDRACT 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alt=\"\u80c3\u764c\u6cbb\u7597\u836f\u7269\u7814\u53d1\u8fdb\u5c55\" title=\"\u80c3\u764c\u6cbb\u7597\u836f\u7269\u7814\u53d1\u8fdb\u5c55\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 17px;\"><\/span><br  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 17px;\"><\/span><span style=\"font-size: 15px;\">\u88684\uff1a\u80c3\u80a0\u9053\u95f4\u8d28\u7624\u5728\u7814\u836f\u7269<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/4-1554966052.jpeg\" alt=\"\u80c3\u764c\u6cbb\u7597\u836f\u7269\u7814\u53d1\u8fdb\u5c55\" title=\"\u80c3\u764c\u6cbb\u7597\u836f\u7269\u7814\u53d1\u8fdb\u5c55\"  \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-family: \u5b8b\u4f53;font-size: 14px;line-height: 16px;text-align: -webkit-center;text-indent: 28px;background-color: rgb(255, 255, 255);\"><\/span><\/p>\n<p><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><strong><span style=\"color: rgb(2, 30, 170);\"><span style=\"font-size: 18px;\">\u5c0f\u7ed3<\/span><\/span><\/strong><\/p>\n<p style=\"text-align: center;\"><strong><span style=\"color: rgb(2, 30, 170);\"><span style=\"font-size: 18px;\"><br  \/><\/span><\/span><\/strong><\/p>\n<p style=\"text-indent: 2em;\"><span style=\"font-size: 15px;\">\u665a\u671f\u80c3\u764c\u7684\u6cbb\u7597\u836f\u7269\u6709\u9650\uff0c\u9776\u5411\u836f\u7269\u7684\u7814\u53d1\u96be\u5ea6\u5927\uff0c\u5f88\u591a\u836f\u7269\u90fd\u5012\u5728\u4e86\u4e34\u5e8a\u2162\u671f\u7814\u7a76\u9636\u6bb5\u3002\u8054\u5408\u7528\u836f\u6216\u8bb8\u662f\u672a\u6765\u80c3\u764c\u836f\u7269\u6cbb\u7597\u7684\u7814\u53d1\u65b9\u5411\uff0c\u5305\u62ec\u591a\u79cd\u9776\u5411\u836f\u7269\u7684\u8054\u5408\uff1b\u5316\u7597\u836f\u7269\u3001\u9776\u5411\u836f\u7269\u4ee5\u53ca\u514d\u75ab\u7597\u6cd5\u7684\u8054\u5408\u7b49\u3002\u968f\u7740\u7cbe\u51c6\u533b\u5b66\u7684\u53d1\u5c55\uff0c\u5bf9\u80c3\u764c\u8fdb\u884c\u66f4\u52a0\u7cbe\u786e\u7684\u5206\u5b50\u5206\u578b\u5bf9\u9776\u5411\u836f\u7269\u7684\u7814\u53d1\u8d77\u5230\u4e86\u79ef\u6781\u7684\u63a8\u52a8\u4f5c\u7528\uff0c\u53ef\u4ee5\u6839\u636e\u751f\u7269\u6807\u5fd7\u7269\u5bf9\u80c3\u764c\u60a3\u8005\u8fdb\u884c\u5408\u7406\u7684\u5206\u7ec4\uff0c\u4ece\u800c\u627e\u5230\u5408\u9002\u7684\u6cbb\u7597\u836f\u7269\u3002\u671f\u671b\u665a\u671f\u80c3\u764c\u7684\u6cbb\u7597\u836f\u7269\u53ef\u4ee5\u5728\u4e0d\u4e45\u7684\u5c06\u6765\u53d6\u5f97\u8f83\u5927\u7684\u7a81\u7834\uff0c\u6709\u6548\u6539\u5584\u665a\u671f\u80c3\u764c\u60a3\u8005\u76845\u5e74\u751f\u5b58\u671f\u3002<\/span><\/p>\n<p><span style=\"font-size: 15px;\"><br  \/><\/span><\/p>\n<p style=\"margin-top: 5px;\"><strong><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">\u53c2\u8003\u8d44\u6599<\/span><\/strong><\/p>\n<p style=\"margin-top: 5px;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">1\u3001Mihaela Chivu-Economescu, Lilia Matei, Laura G .Necula, et al. New therapeutic options opened by the molecular classification of gastric cancer. World J Gastroenterol, 2018, 24(18): 1942-1961.<\/span><\/p>\n<p style=\"margin-top: 5px;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">2\u3001Yuki Kiyozumi, Masaaki Iwatsuki, Kohei Yamashita, et al. Update on targeted therapy and immune therapy for gastric cancer, 2018. J Cancer Metastasis Treat, 2018, 4: 31.<\/span><\/p>\n<p style=\"margin-top: 5px;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">3\u3001\u6768\u5de7\u7ea2, \u5f20\u65b0\u6c5f, \u675c\u6e05, \u7b49. \u80c3\u764c\u9776\u5411\u6cbb\u7597\u673a\u5236\u53ca\u4e2d\u897f\u533b\u836f\u7269\u6cbb\u7597\u60c5\u51b5\u7684\u7814\u7a76\u8fdb\u5c55. \u8f6c\u5316\u533b\u5b66\u7535\u5b50\u6742\u5fd7, 2018, 5(9): 34-42.<\/span><\/p>\n<p style=\"margin-top: 5px;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">4\u3001\u8d75\u6069\u660a, \u8d75\u521a, \u66f9\u6656. \u7cbe\u51c6\u533b\u5b66\u65f6\u4ee3\u80c3\u764c\u8bca\u6cbb\u7684\u73b0\u72b6\u4e0e\u8fdb\u5c55. \u80c3\u80a0\u75c5\u5b66, 2018, 23(6): 321-326.<\/span><\/p>\n<p style=\"margin-top: 5px;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">5\u3001Biomedtraker\u6570\u636e\u5e93\uff08\u68c0\u7d22\u65e5\u671f\uff1a2019-02-22\uff09.<\/span><\/p>\n<p style=\"margin-top: 5px;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">6\u3001Integrity\u6570\u636e\u5e93\uff08\u68c0\u7d22\u65e5\u671f\uff1a2019-02-22\uff09.<\/span><\/p>\n<p style=\"margin-top: 5px;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">7\u3001\u6570\u636e\u5e93\uff08\u68c0\u7d22\u65e5\u671f\uff1a2019-02-27\uff09.<\/span><\/p>\n<p style=\"margin-top: 5px;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">8\u3001\u516c\u5f00\u7f51\u7edc\u76f8\u5173\u62a5\u9053.<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u80c3\u764c\u7684\u5206\u578b \u80c3\u764c\u6307\u6e90\u81ea\u80c3\u7c98\u819c\uff08\u817a\u764c\uff09\u3001\u80c3\u58c1\u7ed3\u7f14\u7ec4\u7ec7\uff08\u80c3\u80a0\u95f4\u8d28\u7624\uff0cGISTs\uff09\u3001\u795e\u7ecf\u5185\u5206\u6ccc\u7ec4\u7ec7\uff08\u7c7b\u764c\uff09\u6216\u6dcb\u5df4\u7ec4\u7ec7 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":82406,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/82405"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=82405"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/82405\/revisions"}],"predecessor-version":[{"id":82415,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/82405\/revisions\/82415"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/82406"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=82405"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=82405"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=82405"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}