{"id":82416,"date":"2019-03-04T00:00:50","date_gmt":"2019-04-11T07:00:57","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/82416\/"},"modified":"2019-04-11T15:01:00","modified_gmt":"2019-04-11T07:01:00","slug":"f010484236","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/82416\/","title":{"rendered":"\u7ee7\u5217\u51652019\u7248NCCN\u6307\u5357\u540e\uff0cTMB\u7684\u6807\u5fd7\u7269\u529f\u80fd\u518d\u6b21\u5728\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u4e2d\u5f97\u5230\u786e\u8ba4"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section class=\"XiGuaChajian\" style=\"display:none;\"  ><\/section>\n<p style=\"line-height: 1.75em;\"><span style=\"color:#000000;\"><span style=\"font-size: 15px;\">\u8f6c\u81ea<\/span><\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section style=\"padding-top: 10px;padding-bottom: 10px;box-sizing: border-box;\">\n<section style=\"margin-top:10px;\"><\/section>\n<section style=\"border-width: 1px;border-style: dashed;border-color: #45b8cc;margin-top: -30px;margin-bottom: -30px;box-sizing: border-box;\">\n<section style=\"padding:30px 30px;box-sizing: border-box;\">\n<section style=\"color: rgb(63, 63, 63);line-height: 1.75em;font-size: 14px;letter-spacing: 1.5px;\" class=\"135brush\">\n<p style=\"line-height: 1.75em;\"><span style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1;font-size: 15px;\">\u514d\u75ab\u7cfb\u7edf\u5728\u80bf\u7624\u76d1\u6d4b\u548c\u6e05\u9664\u7684\u8fdb\u7a0b\u4e2d\u8d77\u7740\u975e\u5e38\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u80bf\u7624\u7ec6\u80de\u5728\u591a\u79cd\u673a\u5236\u7684\u5e2e\u52a9\u4e0b\u505a\u51fa\u514d\u75ab\u9003\u9038\u88ab\u8ba4\u4e3a\u662f\u764c\u75c7\u8fdb\u5c55\u7684\u6807\u5fd7\u4e4b\u4e00\u3002\u4f5c\u4e3a\u514d\u75ab\u7597\u6cd5\u7684\u91cd\u8981\u4ee3\u8868\uff0c\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08Immune checkpoint inhibitor\uff0cICI\uff09\u5bf9\u4e00\u4e9b\u8f6c\u79fb\u6027\u764c\u75c7\u60a3\u8005\u975e\u5e38\u6709\u76ca\uff0c\u4f46\u901a\u5e38\u9700\u8981\u9884\u6d4b\u6027\u751f\u7269\u6807\u5fd7\u7269\u6765\u8bca\u65ad\u60a3\u8005\u3002\u81ea\u80bf\u7624\u7a81\u53d8\u8d1f\u8377\uff08TMB\uff09\u4e0e\u514d\u75ab\u6cbb\u7597\u83b7\u76ca\u4e4b\u95f4\u7684\u5bc6\u5207\u5173\u7cfb\u88ab\u63ed\u793a\u4ee5\u6765\uff0c\u56f4\u7ed5TMB\u7684\u7814\u7a76\u4e5f\u8d8a\u6765\u8d8a\u4e30\u5bcc\u3002\u53bb\u5e7410\u6708\uff0c\u7f8e\u56fdNCCN\uff08\u7efc\u5408\u764c\u75c7\u7f51\u7edc\uff09\u5c06TMB\u6b63\u5f0f\u5217\u5165\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u6307\u5357\uff0c\u6700\u8fd1\u4e00\u671f\u7684Nature Genetics\u6742\u5fd7\u53d1\u8868\u4e86\u4e00\u7bc7\u5173\u4e8eTMB\u7684\u7814\u7a76\u6587\u7ae0\uff0c\u4e3aTMB\u4f5c\u4e3a\u514d\u75ab\u7597\u6cd5\u6807\u5fd7\u7269\u843d\u4e0b\u4e86\u201c\u5b9e\u9524\u201d\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"text-align:right;\"><img class=\"\"     style=\"vertical-align: middle;width: 50px;transform: rotateX(0deg) rotateY(169deg) rotateZ(0deg);-webkit-transform: rotateX(0deg) rotateY(169deg) rotateZ(0deg);-moz-transform: rotateX(0deg) rotateY(169deg) rotateZ(0deg);-ms-transform: rotateX(0deg) rotateY(169deg) rotateZ(0deg);-o-transform: rotateX(0deg) rotateY(169deg) rotateZ(0deg);\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/1-1554966057.png\" alt=\"\u7ee7\u5217\u51652019\u7248NCCN\u6307\u5357\u540e\uff0cTMB\u7684\u6807\u5fd7\u7269\u529f\u80fd\u518d\u6b21\u5728\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u4e2d\u5f97\u5230\u786e\u8ba4\" title=\"\u7ee7\u5217\u51652019\u7248NCCN\u6307\u5357\u540e\uff0cTMB\u7684\u6807\u5fd7\u7269\u529f\u80fd\u518d\u6b21\u5728\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u4e2d\u5f97\u5230\u786e\u8ba4\"  \/><\/section>\n<\/section>\n<\/section>\n<section  class=\"_135editor\" style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<p><br  \/><\/p>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"           style=\"width: 556px;height: 355px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/8-1554966058.jpeg\" alt=\"\u7ee7\u5217\u51652019\u7248NCCN\u6307\u5357\u540e\uff0cTMB\u7684\u6807\u5fd7\u7269\u529f\u80fd\u518d\u6b21\u5728\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u4e2d\u5f97\u5230\u786e\u8ba4\" title=\"\u7ee7\u5217\u51652019\u7248NCCN\u6307\u5357\u540e\uff0cTMB\u7684\u6807\u5fd7\u7269\u529f\u80fd\u518d\u6b21\u5728\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u4e2d\u5f97\u5230\u786e\u8ba4\"  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u514d\u75ab\u5e94\u7b54\u8fc7\u7a0b\uff08\u56fe\u7247\u6e90\u81ea\u53c2\u8003\u6587\u7ae03\uff09<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u4ee5TMB\u4f5c\u4e3a\u6807\u5fd7\u7269\u4e34\u5e8a\u65e9\u5df2\u6709\u5e94\u7528\uff0c\u5728CTLA-4\u6291\u5236\u5242\u6cbb\u7597\u9ed1\u8272\u7d20\u7624\uff0cPD-1\/PD-L1\u6291\u5236\u5242\u6cbb\u7597\u9ed1\u8272\u7d20\u7624\u3001\u8180\u80f1\u764c\u548cNSCLC\u4e2d\u5747\u6709\u89c2\u5bdf\u5230\u9ad8\u7a81\u53d8\u8d1f\u8377TMB\u548c\u4e34\u5e8a\u6548\u76ca\u4e4b\u95f4\u7684\u5173\u8054\u6027\u3002\u4f46\u65e2\u5f80\u7814\u7a76ICI\u6cbb\u7597\u540eTMB\u4e0e\u751f\u5b58\u7387\u5173\u7cfb\u7684\u4e34\u5e8a\u6837\u672c\u91cf\u8f83\u5c0f\uff0c\u76ee\u524d\u5bf9TMB\u662f\u5426\u5177\u6709\u5404\u79cd\u764c\u75c7\u4e34\u5e8a\u83b7\u76ca\u7684\u9884\u6d4b\u6027\u5c1a\u65e0\u5341\u8db3\u628a\u63e1\uff0c\u4e5f\u4e0d\u6e05\u695a\u8fd9\u79cd\u83b7\u76ca\u4e00\u65e6\u8d85\u51fa\u4e34\u5e8a\u7279\u5b9a\u8bd5\u9a8c\u4eba\u7fa4\u540e\u662f\u5426\u8fd8\u6709\u6548\u3002\u4e3a\u4e86\u83b7\u5f97\u66f4\u5e7f\u6cdb\u5730\u6570\u636e\uff0c\u8fd9\u9879\u6700\u65b0\u7814\u7a76\u5171\u56ca\u62ec1662\u540d\u63a5\u53d7ICI\u6cbb\u7597\u665a\u671f\u764c\u75c7\u548c5371\u540d\u672a\u63a5\u53d7ICI\u6cbb\u7597\u60a3\u8005\u7684\u4e34\u5e8a\u548c\u57fa\u56e0\u7ec4\u6570\u636e\uff0c\u5e76\u5bf9\u8fd9\u4e9b\u60a3\u8005\u7684\u80bf\u7624\u91c7\u7528\u4e86\u65b0\u4e00\u4ee3\u9776\u5411\u6d4b\u5e8f\u6280\u672fMSK-IMPACT\u3002\u7ed3\u679c\u53d1\u73b0\u5728\u6240\u6709\u60a3\u8005\u4e2d\uff0c\u9ad8TMB\uff08\u4e0d\u540c\u80bf\u7624\u7ec4\u7ec7\u5747\u503c\u7ea620%\uff09\u4e0e\u8f83\u597d\u7684\u603b\u751f\u5b58\u671f\uff08OS\uff09\u5448\u6b63\u76f8\u5173\uff0c\u8bc1\u660e\u5728\u5927\u591a\u6570\u764c\u75c7\u4e2d\uff0cTMB\u5347\u9ad8\u4e0e\u751f\u5b58\u7387\u63d0\u9ad8\u4e4b\u95f4\u5b58\u5728\u76f8\u5173\u6027\u3002<\/span><\/p>\n<p style=\"line-height: normal;\"><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/9-1554966058.jpeg\" alt=\"\u7ee7\u5217\u51652019\u7248NCCN\u6307\u5357\u540e\uff0cTMB\u7684\u6807\u5fd7\u7269\u529f\u80fd\u518d\u6b21\u5728\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u4e2d\u5f97\u5230\u786e\u8ba4\" title=\"\u7ee7\u5217\u51652019\u7248NCCN\u6307\u5357\u540e\uff0cTMB\u7684\u6807\u5fd7\u7269\u529f\u80fd\u518d\u6b21\u5728\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u4e2d\u5f97\u5230\u786e\u8ba4\"  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">\u4e0d\u540c\u764c\u75c7TMB\u7684\u9608\u503c\u4e0e\u6b7b\u4ea1\u5371\u5bb3\u6bd4\u4e4b\u95f4\u7684\u5173\u7cfb\uff08\u56fe\u7247\u6e90\u81ea\u53c2\u8003\u6587\u7ae02\uff09<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u6b64\u5916\uff0c\u8be5\u7814\u7a76\u8fd8\u5bf9\u6bcf\u4e2a\u764c\u75c7\u7c7b\u578b\u8fdb\u884c\u4e86\u533a\u522b\u6027\u5206\u6790\uff0c\u5c06\u6bcf\u4e2a\u7ec4\u7ec7\u5b66\u4e2d\u7a81\u53d8\u8d1f\u8377\u6700\u9ad8\u7684\u524d20%\u4f5c\u4e3a\u8be5\u764c\u75c7\u7c7b\u578b\u7684TMB\u9ad8\u7ec4\u3002\u8fd9\u6837\u64cd\u4f5c\u7684\u539f\u56e0\u662fTMB\u5728\u4e0d\u540c\u7ec4\u7ec7\u5b66\u4e2d\u5206\u5e03\u4e0d\u540c\uff0c\u6bcf\u79cd\u764c\u75c7\u7c7b\u578bTMB\u524d20%\u7684\u9608\u503c\u5b58\u5728\u663e\u8457\u5dee\u5f02\uff0c\u4e5f\u5c31\u662f\u8bf4\u4e0d\u53ef\u80fd\u6709\u4e00\u4e2a\u901a\u7528\u7684\u9608\u503c\u5b9a\u4e49\u201c\u4f55\u8c13\u9ad8TMB\u201d\uff0c\u6765\u9884\u6d4bICI\u5728\u6240\u6709\u764c\u75c7\u7c7b\u578b\u4e2d\u7684\u4e34\u5e8a\u6548\u76ca\u3002\u8fd9\u79cd\u4e0d\u540c\u80bf\u7624\u7ec4\u7ec7\u5b66\u7684TMB\u5dee\u5f02\u4ee5\u53ca\u5bf9ICI\u5e94\u7b54\u9608\u503c\u7684\u5dee\u5f02\u5f88\u53ef\u80fd\u662f\u7531\u4e8e\u80bf\u7624\u5fae\u73af\u5883\u9020\u6210\u7684\uff0c\u5305\u62ec\u5355\u514b\u9686\u514d\u75ab\u6e17\u900f\u3001\u514d\u75ab\u7ec6\u80de\u6392\u65a5\u3001\u4eba\u7c7b\u767d\u7ec6\u80de\u6297\u539f\u57fa\u56e0\u578b\u53d8\u5316\u548c\u68c0\u67e5\u70b9\u5206\u5b50\u7684\u8868\u8fbe\u6c34\u5e73\u7b49\u56e0\u7d20\u3002<\/span><\/p>\n<p style=\"line-height: normal;\"><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/6-1554966059.jpeg\" alt=\"\u7ee7\u5217\u51652019\u7248NCCN\u6307\u5357\u540e\uff0cTMB\u7684\u6807\u5fd7\u7269\u529f\u80fd\u518d\u6b21\u5728\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u4e2d\u5f97\u5230\u786e\u8ba4\" title=\"\u7ee7\u5217\u51652019\u7248NCCN\u6307\u5357\u540e\uff0cTMB\u7684\u6807\u5fd7\u7269\u529f\u80fd\u518d\u6b21\u5728\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u4e2d\u5f97\u5230\u786e\u8ba4\"  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);text-decoration: none;\">TMB\u7a0b\u5ea6\u5728\u4e0d\u540c\u764c\u75c7\u7c7b\u578b\u4e2d\u7684\u5206\u5e03\u60c5\u51b5\uff08\u56fe\u7247\u6e90\u81ea\u53c2\u8003\u6587\u7ae02\uff09<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u8fd9\u79cd\u5206\u5c42\u7814\u7a76\u66f4\u6709\u5229\u4e8e\u89c2\u5bdf\u4e0d\u540c\u764c\u75c7\u7c7b\u578b\u7684OS\u4e0eTMB\u7684\u5173\u8054\uff0c\u867d\u7136\u53ef\u80fd\u7531\u4e8e\u6837\u672c\u91cf\u7684\u539f\u56e0\uff0c\u5bf9\u4e2a\u522b\u764c\u75c7\uff08\u5982\u80f6\u8d28\u7624\uff09\u7684\u5f71\u54cd\u6ca1\u6709\u8fbe\u5230\u7edf\u8ba1\u5b66\u610f\u4e49\uff0c\u4f46\u51e0\u4e4e\u6240\u6709\u7c7b\u578b\u7684\u764c\u75c7\u90fd\u89c2\u5bdf\u5230\u4e86\u9ad8TMB\u4e0e\u6574\u4f53\u751f\u5b58\u7387\u8f83\u9ad8\u7684\u5927\u8d8b\u52bf\uff0c\u8fd9\u4e9b\u90fd\u8bf4\u660eTMB\u4e0eICI\u672f\u540e\u751f\u5b58\u7387\u63d0\u9ad8\u4e4b\u95f4\u7684\u5173\u7cfb\u53ef\u80fd\u5b58\u5728\u4e8e\u5927\u591a\u6570\u764c\u75c7\u7c7b\u578b\u4e2d\u3002TMB\u5728\u8bb8\u591a\u764c\u75c7\u7ec4\u7ec7\u5b66\u4e0a\u4f5c\u4e3a\u4e00\u4e2a\u8fde\u7eed\u53d8\u91cf\uff0c\u5728\u8f83\u957f\u7684OS\u4e2d\u90fd\u80fd\u89c2\u5bdf\u5230\u7c7b\u4f3c\u7684\u6807\u5fd7\u7269\u5173\u8054\u6027\u8d8b\u52bf\u3002\u4e0eOS\u7684\u6539\u5584\u4e00\u81f4\uff0c\u5728\u5982NSCLC\u3001\u9ed1\u8272\u7d20\u7624\u3001\u98df\u7ba1\u80c3\u764c\u3001\u5934\u9888\u764c\u548c\u80be\u7ec6\u80de\u764c\u7b49\u7c7b\u578b\u4e2d\uff0cTMB\u4e0eICI\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u6216PFS\u4e4b\u95f4\u4e5f\u5b58\u5728\u7c7b\u4f3c\u7684\u76f8\u5173\u6027\u3002<\/span><\/p>\n<p style=\"line-height: normal;\"><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/6-1554966059-1.jpeg\" alt=\"\u7ee7\u5217\u51652019\u7248NCCN\u6307\u5357\u540e\uff0cTMB\u7684\u6807\u5fd7\u7269\u529f\u80fd\u518d\u6b21\u5728\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u4e2d\u5f97\u5230\u786e\u8ba4\" title=\"\u7ee7\u5217\u51652019\u7248NCCN\u6307\u5357\u540e\uff0cTMB\u7684\u6807\u5fd7\u7269\u529f\u80fd\u518d\u6b21\u5728\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u4e2d\u5f97\u5230\u786e\u8ba4\"  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">TMB\u7a0b\u5ea6\u4e0e\u603b\u751f\u5b58\u671f\u4e4b\u95f4\u7684\u5173\u8054\u6027\uff08\u56fe\u7247\u6e90\u81ea\u53c2\u8003\u6587\u7ae02\uff09<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u7814\u7a76\u4eba\u5458\u8fd8\u5bf95371\u540d\u8f6c\u79fb\u6027\u764c\u75c7\u5e76\u4e14\u6ca1\u6709\u63a5\u53d7\u8fc7ICI\u6cbb\u7597\u7684\u60a3\u8005\u80bf\u7624\u505a\u4e86MSK-IMPACT\u6d4b\u5e8f\uff0c\u5728\u8fd9\u4e9b\u60a3\u8005\u4e2d\uff0cTMB\u7684\u5347\u9ad8\u4e0eOS\u7684\u63d0\u9ad8\u6ca1\u6709\u5173\u8054\u6027\u3002\u8fd9\u5c31\u6392\u9664\u4e86\u8fd9\u79cdTMB\u4e0e\u60a3\u8005\u751f\u5b58\u7387\u7684\u6b63\u5173\u8054\u4ec5\u4ec5\u662f\u7531\u9884\u540e\u60a3\u8005\u95f4\u7684TMB\u5dee\u5f02\u5bfc\u81f4\u7684\uff0c\u800c\u4e0eICI\u6cbb\u7597\u65e0\u5173\u8fd9\u6837\u4e00\u79cd\u53ef\u80fd\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u8fd9\u9879\u7814\u7a76\u6210\u679c\u89e3\u51b3\u4e86\u80bf\u7624\u514d\u75ab\u5b66\u4e2d\u51e0\u4e2a\u91cd\u8981\u7684\u57fa\u672c\u95ee\u9898\uff1a\u4e00\u662f\u9a8c\u8bc1\u4e86\u7a81\u53d8\u8d1f\u8377\u53ef\u4ee5\u7528\u6765\u9884\u6d4b\u63a5\u53d7\u6297CTLA-4\u6216\u6297PD-1\u6cbb\u7597\u60a3\u8005\u7684\u751f\u5b58\u7387\u3002\u4e8c\u662f\u8fd9\u9879\u7814\u7a76\u91c7\u7528\u4e86\u8fc4\u4eca\u4e3a\u6b62\u4f7f\u7528ICI\u6cbb\u7597\u7684\u6700\u5927\u89c4\u6a21\u60a3\u8005\u57fa\u56e0\u7ec4\u6570\u636e\uff0c\u53ef\u4ee5\u5bf9TMB\u7684\u4e34\u5e8a\u7597\u6548\u5f71\u54cd\u8fdb\u884c\u91cf\u5316\u5206\u6790\uff0c\u8bc1\u660e\u8f83\u9ad8TMB\u4e0e\u8f83\u9ad8OS\u4e4b\u95f4\u7684\u6301\u7eed\u76f8\u5173\u6027\u3002\u6700\u540e\uff0c\u7814\u7a76\u53d1\u73b0\u5bf9\u201c\u9ad8\u201dTMB\u7684\u5b9a\u4e49\u8981\u56e0\u764c\u75c7\u4e0d\u540c\u7c7b\u578b\u800c\u5f02\uff0c\u5f88\u96be\u7528\u4e00\u4e2a\u901a\u7528\u9608\u503c\u6765\u9884\u6d4b\u6240\u6709\u764c\u75c7\u60a3\u8005\u4eceICI\u83b7\u76ca\u7684\u53ef\u80fd\u3002\u603b\u4e4b\uff0c\u8fd9\u4e00\u53d1\u73b0\u518d\u6b21\u5f3a\u8c03\u4e86TMB\u4f5c\u4e3a\u9884\u6d4b\u6027\u751f\u7269\u6807\u5fd7\u7269\u7684\u53ef\u9760\u6027\uff0c\u5177\u6709\u91cd\u8981\u7684\u4e34\u5e8a\u4ef7\u503c\u3002<\/span><\/p>\n<p style=\"line-height: normal;\"><br  \/><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/1-1554966060.jpeg\" alt=\"\u7ee7\u5217\u51652019\u7248NCCN\u6307\u5357\u540e\uff0cTMB\u7684\u6807\u5fd7\u7269\u529f\u80fd\u518d\u6b21\u5728\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u4e2d\u5f97\u5230\u786e\u8ba4\" title=\"\u7ee7\u5217\u51652019\u7248NCCN\u6307\u5357\u540e\uff0cTMB\u7684\u6807\u5fd7\u7269\u529f\u80fd\u518d\u6b21\u5728\u591a\u79cd\u764c\u75c7\u7c7b\u578b\u4e2d\u5f97\u5230\u786e\u8ba4\"  \/><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"color: rgb(136, 136, 136);font-size: 14px;\">TMB\u4f5c\u4e3a\u6807\u5fd7\u7269\u5bf9ICI\u6cbb\u7597NSCLC\u7684\u4e34\u5e8a\u83b7\u76ca\u9884\u6d4b\uff08\u56fe\u7247\u6e90\u81ea\u53c2\u8003\u6587\u7ae02\uff09<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u9274\u4e8e\u514d\u75ab\u6cbb\u7597\u7684\u6f5c\u5728\u6bd2\u6027\u548c\u5bf9ICI\u7684\u9ad8\u5ea6\u53ef\u53d8\u53cd\u5e94\uff0c\u4ee5\u53ca\u8fd9\u7c7b\u7597\u6cd5\u7684\u5de8\u5927\u7ecf\u6d4e\u6210\u672c\uff0c\u8feb\u5207\u9700\u8981\u80fd\u591f\u7528\u6765\u9884\u6d4b\u6307\u5bfcICI\u7528\u836f\u7684\u9633\u6027\u6216\u9634\u6027\u9884\u6d4b\u751f\u7269\u6807\u5fd7\u7269\u3002\u9633\u6027\u9884\u6d4b\u53ef\u4ee5\u6b63\u786e\u5224\u65ad\u54ea\u4e9b\u60a3\u8005\u80fd\u591f\u4ea7\u751f\u6cbb\u7597\u54cd\u5e94\uff1b\u800c\u9634\u6027\u9884\u6d4b\u7528\u6765\u786e\u5b9a\u54ea\u4e9b\u60a3\u8005\u4ece\u5f53\u524d\u7597\u6cd5\u4e2d\u65e0\u6cd5\u83b7\u76ca\u3002\u5229\u7528\u751f\u7269\u6807\u5fd7\u7269\u53ef\u4ee5\u5bf9\u60a3\u8005\u8fdb\u884c\u5355\u836f\u6216\u8054\u5408\u7528\u836f\u7684\u5206\u7ec4\uff0c\u6216\u662f\u51b3\u5b9a\u5c06\u514d\u75ab\u7597\u6cd5\u7528\u4e8e\u4e0d\u540c\u60a3\u8005\u7fa4\u7684\u4e00\u7ebf\u548c\u633d\u6551\u6cbb\u7597\uff0c\u6216\u662f\u91c7\u7528\u66ff\u4ee3\u7597\u6cd5\u4ee5\u907f\u514d\u4e0d\u5fc5\u8981\u7684\u6bd2\u6027\u3002\u9664TMB\u5916\uff0c\u76ee\u524d\u5df2\u9a8c\u8bc1\u5177\u6709\u514d\u75ab\u7597\u6cd5\u751f\u7269\u6807\u5fd7\u7269\u4f5c\u7528\u7684\u6709PD-L1\u8868\u8fbe\u3001\u6dcb\u5df4\u7ec6\u80de\u6d78\u6da6\u6c34\u5e73\u3001T\u7ec6\u80de\u53d7\u4f53\u514b\u9686\u6027\u3001\u5916\u5468\u8840\u6807\u5fd7\u7269\u3001\u514d\u75ab\u76f8\u5173\u57fa\u56e0\u8868\u8fbe\u4ee5\u53ca\u591a\u8def\u590d\u7528\u514d\u75ab\u7ec4\u5316\u7b49\uff0c\u4e0b\u9762\u7b80\u8981\u4ecb\u7ecd\u4e00\u4e0b\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;display: inline-block;box-sizing: border-box;\"  >\n<p style=\"margin-top: 8px;padding-right: 10px;font-weight: bold;line-height: 28px;max-width: 100%;color: rgb(0, 128, 255);min-height: 32px;border-bottom: 2px solid rgb(0, 128, 255);border-top-color: rgb(0, 128, 255);border-right-color: rgb(0, 128, 255);border-left-color: rgb(0, 128, 255);\"><span class=\"autonum\" placeholder=\"1\" style=\"border-radius: 80% 100% 90% 20%;color: rgb(255, 255, 255);display: block;float: left;line-height: 20px;margin-right: 8px;max-width: 100%;padding: 4px 10px;background-color: rgb(0, 128, 255);\"  title=\"\">1<\/span><strong class=\"135brush\"  style=\"letter-spacing: 2px;display: inline-block;\"><span style=\"font-family: -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;font-size: 15px;\">PD-L1\u8868\u8fbe<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<section  class=\"_135editor\" style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<p><br  \/><\/p>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u5728Nivolumab\u7528\u4e8e\u9ed1\u7d20\u7624\u3001NSCLC\u3001\u80be\u7ec6\u80de\u764c\u3001\u524d\u5217\u817a\u764c\u548c\u7ed3\u76f4\u80a0\u764c\u7684I\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\u53d1\u73b0\uff0c\u901a\u8fc7\u68c0\u6d4b\u80bf\u7624\u7ec6\u80de\u7684PD-L1\u8868\u8fbe\u53ef\u4ee5\u4f5c\u4e3a\u6297PD-1\u3001PD-L1\u6cbb\u7597\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002\u5c065%\u8bbe\u5b9a\u4e3a\u80bf\u7624\u7ec6\u80dePD-L1\u9633\u6027\u9608\u503c\uff0c\u572825\u4f8bPD-L1\u9633\u6027\u60a3\u8005\u4e2d\u67099\u4f8b\uff0836%\uff09\u5bf9Nivolumab\u51fa\u73b0ORR\uff0c\u9634\u6027\u60a3\u8005\u4e2d\u6ca1\u6709\u8868\u73b0\u51faORR\uff0c\u5728\u665a\u671f\u9ed1\u8272\u7d20\u7624\u548cNSCLC\u60a3\u8005\u4e2d\u9633\u6027\u7ec4\u6bd4\u9634\u6027\u7ec4\u7684PFS\u548cOS\u4e5f\u90fd\u6709\u663e\u8457\u63d0\u9ad8\uff0cFDA\u5df2\u6279\u51c6\u5c06PD-L1\u4f34\u968f\u8bca\u65ad\u7528\u4e8e\u665a\u671fNSCLC\u548c\u8180\u80f1\u764c\u7684\u6cbb\u7597\u3002\u4f46\u662f\u53d7PD-L1\u8868\u8fbe\u591a\u673a\u5236\u8c03\u63a7\u548c\u80bf\u7624\u5fae\u73af\u5883\u5f71\u54cd\uff0cPD-L1\u7684\u8868\u8fbe\u5177\u6709\u53d6\u6837\u65f6\u95f4\u5dee\u5f02\u3001\u60a3\u8005\u4e2a\u4f53\u5dee\u5f02\u3001\u751a\u81f3\u7624\u5185\u5f02\u8d28\u6027\uff0c\u5176\u9634\u6027\u9884\u6d4b\u4f5c\u7528\u8981\u4f4e\u5f88\u591a\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u5c3d\u7ba1\u5b58\u5728\u8fd9\u4e9b\u5c40\u9650\u6027\uff0cPD-L1\u8868\u8fbe\u5728\u514d\u75ab\u7597\u6cd5\u786e\u5b9a\u53d7\u76ca\u60a3\u8005\u7fa4\u4ecd\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\uff0c\u7279\u522b\u662f\u5728\u76f8\u5173\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u786e\u4fddPD-L1\u9633\u6027\u80bf\u7624\u60a3\u8005\u5728\u6bd4\u8f83\u7fa4\u7ec4\u4e2d\u7684\u5e73\u5747\u5206\u5e03\u662f\u975e\u5e38\u5fc5\u8981\u7684\uff0c\u53ef\u4ee5\u907f\u514d\u7531\u751f\u7269\u5b66\u5dee\u5f02\u800c\u5f15\u5165\u7684\u5b9e\u9a8c\u504f\u5dee\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;display: inline-block;box-sizing: border-box;\"  >\n<p style=\"margin-top: 8px;padding-right: 10px;font-weight: bold;line-height: 28px;max-width: 100%;color: rgb(0, 128, 255);min-height: 32px;border-bottom: 2px solid rgb(0, 128, 255);border-top-color: rgb(0, 128, 255);border-right-color: rgb(0, 128, 255);border-left-color: rgb(0, 128, 255);\"><span class=\"autonum\" placeholder=\"1\" style=\"border-radius: 80% 100% 90% 20%;color: rgb(255, 255, 255);display: block;float: left;line-height: 20px;margin-right: 8px;max-width: 100%;padding: 4px 10px;background-color: rgb(0, 128, 255);\"  title=\"\">2<\/span><strong class=\"135brush\"  style=\"letter-spacing: 2px;display: inline-block;\"><span style=\"font-family: -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;font-size: 15px;\">\u6dcb\u5df4\u7ec6\u80de\u6d78\u6da6\u6c34\u5e73<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<section  class=\"_135editor\" style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<p><br  \/><\/p>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u8bb8\u591a\u764c\u75c7\u7684\u56de\u987e\u6027\u7814\u7a76\u90fd\u53d1\u73b0\uff0c\u6dcb\u5df4\u7ec6\u80de\u7684\u6d78\u6da6\u7a0b\u5ea6\u4e0e\u60a3\u8005\u751f\u5b58\u7387\u6709\u5173\u8054\uff0c\u5728\u5b9e\u4f53\u80bf\u7624\u805a\u96c6\u5904\uff0c\u5982\u7ed3\u76f4\u80a0\u764c\u548c\u9ed1\u8272\u7d20\u7624\u4e2d\u53d1\u73b0\u5f02\u4f4d\u6dcb\u5df4\u7ed3\u72b6\u7ed3\u6784\u80fd\u591f\u66f4\u597d\u5730\u9884\u6d4b\u60a3\u8005\u751f\u5b58\u3002\u4f8b\u5982\uff0c\u4e0eCD8+\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\u7a0b\u5ea6\u8f83\u4f4e\u7684\u653e\u5316\u7597III\u671fNSCLC\u60a3\u8005\u76f8\u6bd4\uff0c\u80bf\u7624\u6d78\u6da6\u7a0b\u5ea6\u9ad8\u7684\u60a3\u8005\u7fa4PFS\u548cOS\u90fd\u66f4\u957f\u3002\u8fd9\u79cd\u6dcb\u5df4\u7ec6\u80de\u6d78\u6da6\u7a0b\u5ea6\u7684\u80cc\u540e\u673a\u7406\u88ab\u8ba4\u4e3a\u662f\u80fd\u591f\u6fc0\u8d77\u81ea\u8eab\u514d\u75ab\u5e94\u7b54\u6216T\u7ec6\u80de\u708e\u75c7\u80bf\u7624\u8868\u578b\uff0c\u901a\u8fc7\u514d\u75ab\u673a\u5236\u6539\u5584\u75be\u75c5\u63a7\u5236\uff0c\u56e0\u6b64\u53ef\u4ee5\u4f5c\u4e3a\u9884\u540e\u751f\u7269\u6807\u5fd7\u7269\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;display: inline-block;box-sizing: border-box;\"  >\n<p style=\"margin-top: 8px;padding-right: 10px;font-weight: bold;line-height: 28px;max-width: 100%;color: rgb(0, 128, 255);min-height: 32px;border-bottom: 2px solid rgb(0, 128, 255);border-top-color: rgb(0, 128, 255);border-right-color: rgb(0, 128, 255);border-left-color: rgb(0, 128, 255);\"><span class=\"autonum\" placeholder=\"1\" style=\"border-radius: 80% 100% 90% 20%;color: rgb(255, 255, 255);display: block;float: left;line-height: 20px;margin-right: 8px;max-width: 100%;padding: 4px 10px;background-color: rgb(0, 128, 255);\"  title=\"\">3<\/span><strong class=\"135brush\"  style=\"letter-spacing: 2px;display: inline-block;\"><span style=\"font-family: -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;font-size: 15px;\">T\u7ec6\u80de\u53d7\u4f53\u514b\u9686<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<section  class=\"_135editor\" style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<p><br  \/><\/p>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u7814\u7a76\u53d1\u73b0\u80bf\u7624\u6dcb\u5df4\u7ec6\u80de\u6d78\u6da6\u7684T\u7ec6\u80de\u53d7\u4f53\u9776\u5411\u80bf\u7624\u7279\u5f02\u6027\u514d\u75ab\u53cd\u5e94\uff0c\u4e0ePembrolizumab\u7684\u4e34\u5e8a\u5e94\u7b54\u76f8\u5173\uff0c\u7ed3\u679c\u8868\u660e\u57fa\u7ebfT\u7ec6\u80de\u53d7\u4f53\u514b\u9686\u6027\u4e0e\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\u5bc6\u5ea6\u7684\u76f8\u5173\u6027\u4e0d\u9ad8\u3002\u5f53\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\u9650\u5236\u4e86T\u7ec6\u80de\u53d7\u4f53\u5bf9\u80bf\u7624\u6297\u539f\u7684\u7279\u5f02\u6027\u514b\u9686\uff0c\u5373\u4fbf\u662f\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\u5bc6\u5ea6\u8f83\u4f4e\u7684\u60a3\u8005\uff0c\u4ecd\u7136\u53ef\u4ee5\u5728\u6297PD-1\u6cbb\u7597\u4e2d\u83b7\u76ca\u3002\u5f53\u7136\u8fd9\u79cd\u5047\u8bbe\u5c1a\u9700\u8981\u4ece\u5927\u91cf\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5f97\u5230\u8fdb\u4e00\u6b65\u9a8c\u8bc1\uff0c\u5e76\u4e14\u53ef\u80fd\u8fd8\u9700\u8981\u786e\u8ba4\u53ef\u8bc6\u522b\u7684\u80bf\u7624\u6297\u539f\uff0c\u7136\u540e\u624d\u80fd\u5c06\u8be5\u65b9\u6cd5\u5e94\u7528\u4e8e\u751f\u7269\u6807\u5fd7\u7269\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;display: inline-block;box-sizing: border-box;\"  >\n<p style=\"margin-top: 8px;padding-right: 10px;font-weight: bold;line-height: 28px;max-width: 100%;color: rgb(0, 128, 255);min-height: 32px;border-bottom: 2px solid rgb(0, 128, 255);border-top-color: rgb(0, 128, 255);border-right-color: rgb(0, 128, 255);border-left-color: rgb(0, 128, 255);\"><span class=\"autonum\" placeholder=\"1\" style=\"border-radius: 80% 100% 90% 20%;color: rgb(255, 255, 255);display: block;float: left;line-height: 20px;margin-right: 8px;max-width: 100%;padding: 4px 10px;background-color: rgb(0, 128, 255);\"  title=\"\">4<\/span><strong class=\"135brush\"  style=\"letter-spacing: 2px;display: inline-block;\"><span style=\"font-family: -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;font-size: 15px;\">\u5916\u5468\u8840\u6807\u5fd7\u7269<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<section  class=\"_135editor\" style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<p><br  \/><\/p>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u5916\u5468\u8840\u6807\u5fd7\u7269\u7684\u4f18\u52bf\u5728\u4e8e\u975e\u4fb5\u5165\u6027\u7684\u6837\u54c1\u91c7\u96c6\u65b9\u5f0f\uff0c\u867d\u7136\u8fd9\u7c7b\u6807\u5fd7\u7269\u4e0e\u4e34\u5e8a\u7597\u6548\u7684\u4e00\u4e9b\u5173\u8054\u6027\u5df2\u6709\u7814\u7a76\uff0c\u4f46\u662f\u5c1a\u672a\u6709\u8fd9\u7c7b\u6807\u5fd7\u7269\u771f\u6b63\u201c\u843d\u5730\u201d\u5177\u5907\u7597\u6cd5\u9884\u6d4b\u6027\u3002\u4ee5Ipilimumab\u4e3a\u4f8b\uff0c\u76f8\u5173\u4e34\u5e8a\u7814\u7a76\u53d1\u73b0\u4ee5\u4e0b\u6307\u6807\u4e0e\u60a3\u8005PFS\u6709\u5173\uff0c\u5305\u62ec\u4f4e\u7edd\u5bf9\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570(&lt; 7500\u4e2a\u7ec6\u80de\/\u03bcL)\uff0c\u4e2d\u6027\u7c92\u7ec6\u80de\u6dcb\u5df4\u7ec6\u80de\u6bd4\u4f8b\u4f4e(&lt; 3)\uff0c\u7edd\u5bf9\u7684\u5355\u6838\u7ec6\u80de\u8ba1\u6570\u4f4e(&lt; 650\u7ec6\u80de\/\u03bcL)\uff0c\u4f4e\u9891\u9ad3\u6837\u6291\u5236\u7ec6\u80de(&lt; 5\u00b71%)\u3001\u9ad8\u9891FoxP3+\u8c03\u8282\u6027T\u7ec6\u80de(\u22651\u00b75%)\uff0c\u9ad8\u9891\u7387\u7684\u6dcb\u5df4\u7ec6\u80de(\u226510\u00b75%)\uff0c\u4ee5\u53ca\u9ad8\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u8ba1\u6570(\u226550\u4e2a\u7ec6\u80de\/\u03bcL)\uff0c\u5728\u6297PD-1\u6cbb\u7597\u7814\u7a76\u4e2d\u4e5f\u53d1\u73b0\u4e86\u4e00\u4e9b\u7c7b\u4f3c\u7684\u7ed3\u679c\u3002\u6b64\u5916\uff0c\u5916\u5468T\u7ec6\u80de\u6570\u91cf\uff0c\u5c24\u5176\u662fT\u7ec6\u80de\u53d7\u4f53\u57fa\u56e0\u5e8f\u5217\u6216\u5bf9\u65b0\u6297\u539f\u7684\u53cd\u5e94\u6027\u8bc4\u4f30\u4e5f\u53ef\u4ee5\u4f5c\u4e3a\u4e00\u79cd\u9884\u6d4b\u751f\u7269\u6807\u5fd7\u7269\u53d1\u6325\u6f5c\u5728\u4f5c\u7528\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;display: inline-block;box-sizing: border-box;\"  >\n<p style=\"margin-top: 8px;padding-right: 10px;font-weight: bold;line-height: 28px;max-width: 100%;color: rgb(0, 128, 255);min-height: 32px;border-bottom: 2px solid rgb(0, 128, 255);border-top-color: rgb(0, 128, 255);border-right-color: rgb(0, 128, 255);border-left-color: rgb(0, 128, 255);\"><span class=\"autonum\" placeholder=\"1\" style=\"border-radius: 80% 100% 90% 20%;color: rgb(255, 255, 255);display: block;float: left;line-height: 20px;margin-right: 8px;max-width: 100%;padding: 4px 10px;background-color: rgb(0, 128, 255);\"  title=\"\">5<\/span><strong class=\"135brush\"  style=\"letter-spacing: 2px;display: inline-block;\"><span style=\"font-family: -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;font-size: 15px;\">\u514d\u75ab\u76f8\u5173\u57fa\u56e0\u8868\u8fbe<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<section  class=\"_135editor\" style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<p><br  \/><\/p>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u901a\u8fc7\u57fa\u56e0\u8868\u8fbe\u5bf9\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u6d3b\u8dc3\u7684\u5148\u5929\u6216\u9002\u5e94\u6027\u514d\u75ab\u53cd\u5e94\u8fdb\u884c\u66f4\u5e7f\u6cdb\u7684\u8bc4\u4f30\uff0c\u53ef\u4ee5\u6709\u6548\u5730\u9884\u6d4bICI\u7597\u6cd5\u7684\u4e34\u5e8a\u6548\u76ca\u3002\u5bf9\u665a\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u4f7f\u7528Ipilimumab\u7684II\u671f\u4e34\u5e8a\u56de\u987e\u6027\u5206\u6790\u8bc1\u660e\uff0c\u57fa\u56e0\u8868\u8fbe\u8c31\u56fe\u786e\u5b9e\u662f\u4e00\u79cd\u6709\u7528\u7684\u9884\u6d4b\u751f\u7269\u6807\u5fd7\u7269\u3002\u7814\u7a76\u4eba\u5458\u63d0\u53d6\u4e8650\u4efd\u6cbb\u7597\u524d\u80bf\u7624\u6d3b\u68c0\u6807\u672c\u7684\u603bRNA\u8fdb\u884c\u5206\u6790\uff0c\u5c06\u60a3\u8005\u5206\u4e3a\u6709\u4e34\u5e8a\u5e94\u7b54\u548c\u65e0\u5e94\u7b54\u4e24\u7ec4\uff0c\u5bf9\u4e24\u7ec4\u4e4b\u95f4\u5b58\u5728\u663e\u8457\u5dee\u5f02\u7684\u57fa\u56e0\u8fdb\u884c\u901a\u8def\u5206\u6790\u540e\u53d1\u73b0\u5173\u8054\u708e\u75c7\u53cd\u5e94\u300222\u4e2a\u4e0e\u514d\u75ab\u76f8\u5173\u7684\u57fa\u56e0\u8868\u8fbe\u81f3\u5c11\u589e\u52a0\u4e862\u00b75\u500d\uff0c\u5305\u62ec\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\uff08\u5982CD8A\u3001\u9897\u7c92\u9176B\u3001\u7a7f\u5b54\u86cb\u767dI\uff09\u3001Th1\u7ec6\u80de\u56e0\u5b50\u6216\u8d8b\u5316\u56e0\u5b50\u3001MHCII\u7c7b\u548c\u5176\u4ed6\u514d\u75ab\u76f8\u5173\u57fa\u56e0(\u5982NKG7\u3001IDO1)\u7684\u6807\u5fd7\u7269\uff0c\u5747\u4e0eOS\u5ef6\u957f\u76f8\u5173\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;display: inline-block;box-sizing: border-box;\"  >\n<p style=\"margin-top: 8px;padding-right: 10px;font-weight: bold;line-height: 28px;max-width: 100%;color: rgb(0, 128, 255);min-height: 32px;border-bottom: 2px solid rgb(0, 128, 255);border-top-color: rgb(0, 128, 255);border-right-color: rgb(0, 128, 255);border-left-color: rgb(0, 128, 255);\"><span class=\"autonum\" placeholder=\"1\" style=\"border-radius: 80% 100% 90% 20%;color: rgb(255, 255, 255);display: block;float: left;line-height: 20px;margin-right: 8px;max-width: 100%;padding: 4px 10px;background-color: rgb(0, 128, 255);\"  title=\"\">6<\/span><strong class=\"135brush\"  style=\"letter-spacing: 2px;display: inline-block;\"><span style=\"font-family: -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;font-size: 15px;\">\u591a\u8def\u590d\u7528\u514d\u75ab\u7ec4\u5316<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<section  class=\"_135editor\" style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<p><br  \/><\/p>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u901a\u8fc7\u591a\u91cd\u514d\u75ab\u7ec4\u5316\u6280\u672f\u76f4\u63a5\u8bc4\u4ef7\u80bf\u7624\u548c\u514d\u75ab\u7ec6\u80de\u8868\u578b\u53ca\u5176\u7a7a\u95f4\u5173\u7cfb\uff0c\u63d0\u4f9b\u4e86\u80bf\u7624\u5fae\u73af\u5883\u514d\u75ab\u72b6\u6001\u7684\u4fe1\u606f\uff0c\u8fd9\u4e9b\u4fe1\u606f\u53ef\u4ee5\u4f5c\u4e3a\u57fa\u56e0\u8868\u8fbe\u8c31\u7684\u8865\u5145\u3002\u5305\u62ec\u7528\u5355\u4e2a\u521d\u7ea7\u6297\u4f53\u5bf9\u80bf\u7624\u5207\u7247\u8fdb\u884c\u8fde\u7eed\u67d3\u8272\uff0c\u4ee5\u83b7\u5f97\u611f\u5174\u8da3\u7684\u86cb\u767d\u8d28\uff0c\u5e76\u7528\u663e\u8272\u6216\u514d\u75ab\u8367\u5149\u6cd5\u8fdb\u884c\u68c0\u6d4b\uff0c\u8fd9\u79cd\u591a\u5149\u8c31\u65b9\u6cd5\u5728\u4e34\u5e8a\u5e94\u7528\u4e2d\u5177\u6709\u5f88\u5927\u7684\u6f5c\u529b\u3002\u901a\u8fc7\u5efa\u7acb\u591a\u5149\u8c31\u514d\u75ab\u7ec4\u5316\u5e73\u53f0\uff0c\u5206\u6790\u9ed1\u8272\u7d20\u7624\u8f7d\u7247\u4e0a\u7684CD3\u3001CD8\u3001FoxP3\u3001CD163\u548cPD-L1\uff0c\u9884\u6d4b\u54ea\u4e9b\u60a3\u8005\u80fd\u591f\u6210\u529f\u751f\u6210\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\uff0c\u9009\u62e9\u5408\u9002\u7684\u7ec6\u80de\u7597\u6cd5\u3002\u4ec5CD8+ T\u7ec6\u80de\u7684\u5b58\u5728\u4e0d\u8db3\u4ee5\u9884\u6d4b\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\u7684\u6210\u529f\u751f\u957f\uff0c\u4f46\u662fCD8+ T\u7ec6\u80de\u4e0eCD3+FoxP3+\u8c03\u8282\u6027T\u7ec6\u80de\u6bd4\u503c\u4e0e\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\u7684\u6210\u529f\u751f\u957f\u5bc6\u5207\u76f8\u5173\u3002PD-L1+\u7684\u52a0\u5165\u4f7f\u9634\u6027\u9884\u6d4b\u503c\u63d0\u9ad8\u4e86100%\uff0c\u8fd9\u79cd\u65b9\u6cd5\u4e5f\u53ef\u4ee5\u5e94\u7528\u4e8e\u5176\u4ed6\u514d\u75ab\u7597\u6cd5\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;display: inline-block;box-sizing: border-box;\"  >\n<p style=\"margin-top: 8px;padding-right: 10px;font-weight: bold;line-height: 28px;max-width: 100%;color: rgb(0, 128, 255);min-height: 32px;border-bottom: 2px solid rgb(0, 128, 255);border-top-color: rgb(0, 128, 255);border-right-color: rgb(0, 128, 255);border-left-color: rgb(0, 128, 255);\"><span class=\"autonum\" placeholder=\"1\" style=\"border-radius: 80% 100% 90% 20%;color: rgb(255, 255, 255);display: block;float: left;line-height: 20px;margin-right: 8px;max-width: 100%;padding: 4px 10px;background-color: rgb(0, 128, 255);\"  title=\"\">7<\/span><strong class=\"135brush\"  style=\"letter-spacing: 2px;display: inline-block;\"><span style=\"font-family: -apple-system-font, BlinkMacSystemFont, Arial, sans-serif;font-size: 15px;\">\u6807\u5fd7\u7269\u5408\u7528\u7b56\u7565<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<section  class=\"_135editor\" style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<p><br  \/><\/p>\n<\/section>\n<\/section>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u5c06\u4e24\u79cd\u6216\u4e24\u79cd\u4ee5\u4e0a\u6807\u5fd7\u7269\u7b56\u7565\u8054\u5408\u4f7f\u7528\u6765\u6355\u6349\u80bf\u7624\u5fae\u73af\u5883\u514d\u75ab\u72b6\u6001\uff0c\u53ef\u4ee5\u5bf9ICI\u6cbb\u7597\u66f4\u6709\u6548\u3002\u4ee5PD-L1\u8868\u8fbe\u548c\u6dcb\u5df4\u7ec6\u80de\u6d78\u6da6\u4e3a\u4f8b\uff0c\u4e24\u8005\u53ef\u80fd\u5728\u80bf\u7624\u7ec6\u80de\u5448\u73b0\u76f8\u53cd\u7684\u60c5\u51b5\uff0cPD-L1\u8868\u8fbe\u8f83\u9ad8\u65f6\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\u8ba1\u6570\u8f83\u4f4e\uff0c\u53cd\u4e4b\u4ea6\u7136\uff0c\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u6297PD-1\u6216\u6297PD-L1\u5355\u4e00\u6cbb\u7597\u7684\u4e34\u5e8a\u54cd\u5e94\u53ef\u80fd\u8f83\u4f4e\uff0c\u800c\u4ec5\u4ee5PD-L1\u8868\u8fbe\u6216\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\u5bc6\u5ea6\u4f5c\u4e3a\u751f\u7269\u6807\u5fd7\u7269\uff0c\u4f1a\u4ea7\u751f\u9519\u8bef\u7684\u9884\u6d4b\u3002\u540c\u6837\uff0c\u5e76\u975e\u6240\u6709\u9ad8\u7a81\u53d8\u6216\u65b0\u6297\u539f\u8d1f\u8377\u80bf\u7624\u90fd\u8868\u73b0\u51fa\u201c\u5148\u5929\u201d\u7684\u514d\u75ab\u6027\uff0c\u8fd9\u88ab\u8ba4\u4e3a\u662f\u514d\u75ab\u6cbb\u7597\u65b9\u6cd5\u7684\u5148\u51b3\u6761\u4ef6\u4e4b\u4e00\u3002\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u8fd8\u5b58\u5728\u591a\u79cd\u5e76\u53d1\u514d\u75ab\u6291\u5236\u673a\u5236\uff0c\u5305\u62ecCTLA-4\u3001PD-L2\u3001LAG3\u3001IDO1\u548cIL-10\uff0c\u968f\u7740\u65b0\u7684\u8054\u5408\u6cbb\u7597\u7b56\u7565\u7684\u51fa\u73b0\uff0c\u8fd9\u4e9b\u90fd\u53ef\u80fd\u6210\u4e3a\u91cd\u8981\u7684\u8bc6\u522b\u9776\u70b9\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">\u53c2\u8003\u6587\u7ae0\uff1a<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">[1]BMS Withdraws Application for Nivolumab\/Ipilimumab in TMB-High NSCLC.<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">[2]Tumor mutational load predicts survival after immunotherapy across multiple cancer types.<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">[3]Predictive biomarkers for checkpoint inhibitorbased immunotherapy.<\/span><\/p>\n<p style=\"text-align: left;line-height: normal;\"><span style=\"font-size: 12px;color: rgb(136, 136, 136);\">[4]Approaches to treat immune hot, altered and cold trumors with combination immunotherapies.<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u8f6c\u81ea \u514d\u75ab\u7cfb\u7edf\u5728\u80bf\u7624\u76d1\u6d4b\u548c\u6e05\u9664\u7684\u8fdb\u7a0b\u4e2d\u8d77\u7740\u975e\u5e38\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u80bf\u7624\u7ec6\u80de\u5728\u591a\u79cd\u673a\u5236\u7684\u5e2e\u52a9\u4e0b\u505a\u51fa\u514d\u75ab\u9003\u9038\u88ab\u8ba4\u4e3a\u662f\u764c\u75c7\u8fdb [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":82417,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/82416"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=82416"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/82416\/revisions"}],"predecessor-version":[{"id":82424,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/82416\/revisions\/82424"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/82417"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=82416"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=82416"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=82416"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}