{"id":82437,"date":"2019-02-28T00:00:50","date_gmt":"2019-04-11T07:01:08","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/82437\/"},"modified":"2019-04-11T15:01:11","modified_gmt":"2019-04-11T07:01:11","slug":"966a099913","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/82437\/","title":{"rendered":"\u540e\u5965\u8d1d\u80c6\u9178\u65f6\u4ee3\uff1a\u76d8\u70b9\u975e\u753e\u4f53FXR\u6fc0\u52a8\u5242"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<section class=\"XiGuaChajian\" style=\"display:none;\"  ><\/section>\n<p style=\"line-height: 1.75em;\">\u8f6c\u81ea<\/p>\n<p style=\"line-height: 1.75em;\"><br  \/><\/p>\n<p style=\"text-align: center;\">\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"font-size: 14px;color: rgb(136, 136, 136);\">NASH\u6f2b\u753b\uff0c\u56fe\u7247\u6765\u81ea\u7f51\u7edc<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u662f\u75c5\u7406\u53d8\u5316\u4e0e\u9152\u7cbe\u6027\u809d\u708e\u76f8\u4f3c\u4f46\u65e0\u8fc7\u91cf\u996e\u9152\u53f2\u7684\u4e34\u5e8a\u7efc\u5408\u5f81\uff0c\u597d\u53d1\u4e8e\u4e2d\u8001\u5e74\u7279\u522b\u662f\u8d85\u91cd\u80a5\u80d6\u4e2a\u4f53\u3002\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u4e0e\u80a5\u80d6\u3001\u80f0\u5c9b\u7d20\u62b5\u6297\u30012\u578b\u7cd6\u5c3f\u75c5\u3001\u9ad8\u8102\u8840\u75c7\u7b49\u4ee3\u8c22\u7d0a\u4e71\u5173\u7cfb\u5bc6\u5207\uff0c\u81f4\u75c5\u673a\u5236\u6781\u5176\u590d\u6742\u3002\u5176\u4e3b\u8981\u7279\u5f81\u4e3a\u809d\u7ec6\u80de\u5927\u6ce1\u6027\u8102\u80aa\u53d8\u6027\u4f34\u809d\u7ec6\u80de\u635f\u4f24\u548c\u708e\u75c7\uff0c\u4e25\u91cd\u8005\u53ef\u53d1\u5c55\u4e3a\u809d\u786c\u5316\uff0c\u662f\u7f8e\u56fd\u809d\u79fb\u690d\u7b2c\u4e8c\u5927\u75c5\u56e0\uff0c\u9884\u8ba12020\u5e74\u4f1a\u6210\u4e3a\u7b2c\u4e00\u5927\u75c5\u56e0\uff0c\u5c1a\u65e0\u7279\u6b8a\u6cbb\u7597\u63aa\u65bd\u3002\u6839\u636eEvaluatePharme\u7684\u9884\u6d4b\uff0c\u5168\u7403NASH\u836f\u7269\u7684\u5e02\u573a\u89c4\u6a21\u57282025\u5e74\u53ef\u4ee5\u8fbe\u5230400\u4ebf\u7f8e\u5143\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u672c\u6708NASH\u6cbb\u7597\u53f2\u4e0a\u53d6\u5f97\u5212\u65f6\u4ee3\u7684\u8fdb\u5c55\uff0c\u7f8e\u56fd\u751f\u7269\u6280\u672f\u516c\u53f8Intercept\u7684FXR\u6fc0\u52a8\u5242\u5965\u8d1d\u80c6\u9178\uff08OCA\uff0c\u5546\u54c1\u540dOcaliva\uff09\u633a\u8fc7\u4e86\u7b2c\u4e00\u4e2a\u4e09\u671f\u4e34\u5e8a\uff08\u56e0\u4e3a\u4fee\u6539\u4e86\u4e34\u5e8a\u7ec8\u70b9\uff09\uff0c\u7ed3\u679c\u663e\u793a\u7528\u836f18\u4e2a\u6708\u9ad8\u5242\u91cf\u7ec4\uff0825mg\uff09\u81f3\u5c11\u6539\u5584\u4e00\u7ea7\u7ea4\u7ef4\u5316\u60a3\u8005\u6bd4\u4f8b\u663e\u8457\u9ad8\u4e8e\u5bf9\u7167\u7ec4\uff0823%\u5bf912%\uff09\uff0c\u6d88\u606f\u4e00\u51faICPT\u80a1\u7968\u4e00\u5ea6\u4e0a\u626c30%\uff0c\u4f46\u6700\u540e\u4ee5\u4e0a\u626c6%\u6536\u76d8\u3002<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/5-1554966069.jpeg\" alt=\"\u540e\u5965\u8d1d\u80c6\u9178\u65f6\u4ee3\uff1a\u76d8\u70b9\u975e\u753e\u4f53FXR\u6fc0\u52a8\u5242\" title=\"\u540e\u5965\u8d1d\u80c6\u9178\u65f6\u4ee3\uff1a\u76d8\u70b9\u975e\u753e\u4f53FXR\u6fc0\u52a8\u5242\"  \/><\/p>\n<p style=\"line-height: normal;\"><br  \/><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><\/span><\/p>\n<p style=\"line-height: normal;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u867d\u7136OCA\u6709\u53ef\u80fd\u6210\u4e3a\u53f2\u4e0a\u7b2c\u4e00\u4e2aNASH\u836f\u7269\uff0c\u5e02\u573a\u5bf9\u6b64\u5e76\u6ca1\u6709\u8868\u73b0\u51fa\u5174\u594b\u7684\u539f\u56e0\u5728\u4e8e\u8be5\u4e34\u5e8a\u4e2d\u4f4e\u5242\u91cf\u7ec4\u672a\u80fd\u8fbe\u5230\u7edf\u8ba1\u663e\u8457\u533a\u5206\uff0c\u4e14\u53e6\u4e00\u4e2a\u7ec8\u70b9\u7f13\u89e3\u8102\u80aa\u809d\u4e24\u4e2a\u5242\u91cf\u90fd\u6ca1\u6709\u8fbe\u5230\u3002\u5b89\u5168\u6027\u66f4\u662f\u4e00\u76f4\u5907\u53d7\u5173\u6ce8\u7684\u95ee\u9898\uff0c\u9ad8\u5242\u91cf\u7ec4\u670951%\u60a3\u8005\u51fa\u73b0\u76ae\u80a4\u6414\u75d2\u30019%\u60a3\u8005\u56e0\u6b64\u9000\u51fa\u8bd5\u9a8c\uff0c\u4e4b\u524d\u8fd8\u6709\u5347\u9ad8LDL\u548c\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u4e0d\u5e73\u8861\u7b49\u4e0d\u826f\u53cd\u5e94\u66dd\u5149\u3002\u5c3d\u7ba1\u5982\u6b64\uff0c\u4f46\u662f\u8fd9\u4e2a\u8bd5\u9a8c\u7684\u79d1\u5b66\u610f\u4e49\u5374\u662f\u503c\u5f97\u79f0\u9053\u7684\uff0c\u65e0\u7591\u4f1a\u7ed9FXR\u6fc0\u52a8\u5242\u8fd9\u4e2a\u673a\u7406\u589e\u5206\u4e0d\u5c11\uff0c\u672a\u6765\u8054\u5408FXR\u6fc0\u52a8\u5242\u66f4\u662f\u4e00\u4e2a\u91cd\u8981\u7684\u9009\u62e9\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u6982\u5ff5\u65e2\u7136\u5df2\u7ecf\u9a8c\u8bc1\uff0c\u90a3\u4e48\u5f88\u660e\u663e\u73b0\u5728\u6446\u5728FXR\u8d5b\u9053\u4e0a\u7684\u4e00\u4e2a\u95ee\u9898\u662f\u5982\u4f55\u5f00\u53d1\u7597\u6548\u3001\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u90fd\u9ad8\u7684\u5019\u9009\u5316\u5408\u7269\uff0c\u753e\u4f53\u7c7b\u7684\u718a\u53bb\u6c27\u80c6\u9178\uff08UDCA\uff0c\u975eFXR\u6fc0\u52a8\u5242\uff09\u548cOCA\u90fd\u4e0d\u80fd\u6ee1\u8db3\u6807\u51c6\uff0c\u4e8e\u662f\u79d1\u5b66\u5bb6\u4fbf\u628a\u6ce8\u610f\u529b\u8f6c\u79fb\u5230\u975e\u753e\u4f53\u7c7bFXR\u6fc0\u52a8\u5242\u4e0a\u3002\u53e6\u5916\uff0c\u6709\u7814\u7a76\u8868\u660eOCA\u5f15\u53d1\u7619\u75d2\u7684\u539f\u56e0\u53ef\u80fd\u662f\u6fc0\u6d3b\u4e86TGR5\uff08\u5176EC50\u540cFXR\u63a5\u8fd1\uff09\uff0c\u56e0\u6b64\u9009\u62e9\u6027\u4e5f\u662f\u8003\u8651\u7684\u5730\u65b9\u3002\u672c\u6587\u5c06\u68b3\u7406\u4e0b\u76ee\u524d\u4e34\u5e8a\u9636\u6bb5\u8fd8\u6d3b\u8dc3\u7684\u975e\u753e\u4f53FXR\u6fc0\u52a8\u5242\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"color: rgb(0, 128, 255);\"><strong><span style=\"font-size: 15px;\">LJN-452<\/span><\/strong><\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/10-1554966069.jpeg\" alt=\"\u540e\u5965\u8d1d\u80c6\u9178\u65f6\u4ee3\uff1a\u76d8\u70b9\u975e\u753e\u4f53FXR\u6fc0\u52a8\u5242\" title=\"\u540e\u5965\u8d1d\u80c6\u9178\u65f6\u4ee3\uff1a\u76d8\u70b9\u975e\u753e\u4f53FXR\u6fc0\u52a8\u5242\"  \/><\/p>\n<p style=\"line-height: normal;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">LJN-452\uff08Tropifexor\uff09\u662f\u4e00\u79cd\u975e\u753e\u4f53FXR\u6fc0\u52a8\u5242\uff0c\u76ee\u524d\u5904\u4e8e\u6cbb\u7597NASH\u3001\u8102\u80aa\u809d\u548c\u539f\u53d1\u6027\u80c6\u6c41\u6027\u80c6\u7ba1\u708e\u7684\u4e34\u5e8a\u4e8c\u671f\uff0c\u9884\u8ba12019\u5e74\u5b8c\u6210\u3002\u5176\u6700\u521d\u7531\u8bfa\u534e\u5236\u53d1\uff0c\u540e\u6388\u6743\u7ed9\u8f89\u745e\u8fdb\u884c\u5408\u4f5c\u7814\u53d1\u30022016\u5e74\uff0c\u8bfa\u534e\u53d1\u5e03\u4e86LJN452\u7684\u9996\u6b21\u4e34\u5e8a\u6570\u636e\uff0895\u4eba\uff09\uff0c\u7ed3\u679c\u559c\u4eba\u3002LJN452\u5728\u9ad8\u8fbe3mg\u7684\u5355\u5242\u91cf\u4e0b\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u8868\u73b0\u826f\u597d\uff0c\u672a\u89c2\u5bdf\u5230\u836f\u7269\u76f8\u5173\u7684\u4e0d\u826f\u53cd\u5e94\uff0c\u591a\u6b21\u7ed9\u836f\u540e\u672a\u53d1\u73b0\u836f\u7269\u76f8\u5173\u7684\u7619\u75d2\u51fa\u73b0\uff0c\u4e2a\u522b\u53d7\u8bd5\u8005\u51fa\u73b0ALT\uff08\u8c37\u4e19\u8f6c\u6c28\u9176\uff09\/AST\uff08\u8c37\u8349\u8f6c\u6c28\u9176\uff09\u7684\u5347\u9ad8\uff0c\u4f46\u5e76\u4e0d\u9020\u6210\u4e34\u5e8a\u540e\u9057\u75c7\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"color: rgb(0, 128, 255);\"><strong><span style=\"font-size: 15px;\">LMB-763<\/span><\/strong><\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"width: 378px;height: 282px;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/6-1554966069-1.jpeg\" alt=\"\u540e\u5965\u8d1d\u80c6\u9178\u65f6\u4ee3\uff1a\u76d8\u70b9\u975e\u753e\u4f53FXR\u6fc0\u52a8\u5242\" title=\"\u540e\u5965\u8d1d\u80c6\u9178\u65f6\u4ee3\uff1a\u76d8\u70b9\u975e\u753e\u4f53FXR\u6fc0\u52a8\u5242\"  \/><\/p>\n<p style=\"line-height: normal;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">LMB-763\u7531\u8bfa\u534e\u7814\u53d1\uff0c\u76ee\u524d\u5904\u4e8e\u4e34\u5e8a\u4e8c\u671f\uff0c\u7528\u4e8e\u6cbb\u7597\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u548c\u7cd6\u5c3f\u75c5\u6027\u80be\u75c5\u3002\u8bfa\u534e\u6b63\u5728\u5f00\u5c55LMB763\u80f6\u56ca\u7684\u56fd\u9645\u591a\u4e2d\u5fc3\u8bd5\u9a8c\uff0c\u4e8e2018\u5e7405\u6708\u5728\u56fd\u5185\u767b\u8bb0\u4e86\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u62df\u62db\u52df10\u540d\u4e2d\u56fd\u53d7\u8bd5\u8005\uff0c\u65e8\u5728\u8bc4\u4f30\u8868\u578b\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u708e\uff08NASH\uff09\u60a3\u8005\u63a5\u53d7LMB763\u80f6\u56ca\u7ed9\u836f12\u5468\u65f6\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u836f\u4ee3\u52a8\u529b\u5b66\uff08PK\uff09\u548c\u65e9\u671f\u809d\u810f\u5e94\u7b54\uff0c\u8fd9\u662f\u76ee\u524d\u56fd\u5185\u8fdb\u5c55\u6700\u5feb\u7684NASH\u5728\u7814\u65b0\u836f\u9879\u76ee\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"color: rgb(0, 128, 255);\"><strong><span style=\"font-size: 15px;\">GS-9674<\/span><\/strong><\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/1-1554966070.jpeg\" alt=\"\u540e\u5965\u8d1d\u80c6\u9178\u65f6\u4ee3\uff1a\u76d8\u70b9\u975e\u753e\u4f53FXR\u6fc0\u52a8\u5242\" title=\"\u540e\u5965\u8d1d\u80c6\u9178\u65f6\u4ee3\uff1a\u76d8\u70b9\u975e\u753e\u4f53FXR\u6fc0\u52a8\u5242\"  \/><\/p>\n<p style=\"line-height: normal;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">Gilead Science\u662f\u5305\u62ecNASH\u5728\u5185\u809d\u75c5\u7684\u7814\u7a76\u5927\u5bb6\uff0c\u5e03\u5c40\u9776\u70b9\u6709FXR\u3001TGFbeta\u3001ACC\u548cASK1\uff08\u521a\u521a\u4e34\u5e8a\u4e09\u671f\u5931\u8d25\uff09\u3002GS-9674\u7ed3\u6784\u5c1a\u672a\u516c\u5f00\uff0c\u662f\u4e00\u79cdFXR\u975e\u753e\u4f53\u7c7b\uff08\u5f02\u5641\u5511\uff09\u5c0f\u5206\u5b50\u6fc0\u52a8\u5242\uff0c\u6700\u521d\u7531Phenex Pharmaceuticals\u7814\u53d1\uff0c2015\u5e741\u6708\u88ab\u5409\u5229\u5fb7\u6536\u8d2d\u3002\u76ee\u524d\u5904\u4e8e\u6cbb\u7597\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u3001\u539f\u53d1\u6027\u80c6\u6c41\u6027\u80c6\u7ba1\u708e\uff08PBC\uff09\u548c\u539f\u53d1\u6027\u786c\u5316\u6027\u80c6\u7ba1\u708e\uff08PSC\uff09\u7684\u4e34\u5e8a\u4e8c\u671f\u8bd5\u9a8c\u9636\u6bb5\u3002\u4e00\u9879\u9488\u5bf952\u540d\u975e\u809d\u786c\u5316PSC\u60a3\u8005\u6cd5\u4eba\u4e34\u5e8a\u4e8c\u671f\u53cc\u76f2\u3001\u5b89\u6170\u5242\u5bf9\u7167\u8bd5\u9a8cNCT02943460\uff0c\u7ed3\u679c\u663e\u793a100 mg\u7ec4\u60a3\u8005\u7684\u809d\u810f\u751f\u5316\u6709\u663e\u8457\u6539\u5584\u3002\u76ee\u524d\uff0cNASH\u4e34\u5e8a\u6570\u636e\u4e5f\u5df2\u51fa\u6765\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"color: rgb(0, 128, 255);\"><strong><span style=\"font-size: 15px;\">TERN-101<\/span><\/strong><\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/7-1554966070.jpeg\" alt=\"\u540e\u5965\u8d1d\u80c6\u9178\u65f6\u4ee3\uff1a\u76d8\u70b9\u975e\u753e\u4f53FXR\u6fc0\u52a8\u5242\" title=\"\u540e\u5965\u8d1d\u80c6\u9178\u65f6\u4ee3\uff1a\u76d8\u70b9\u975e\u753e\u4f53FXR\u6fc0\u52a8\u5242\"  \/><\/p>\n<p style=\"line-height: normal;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">\u7ed3\u6784\u672a\u516c\u5f00\uff0c\u76ee\u524d\u5904\u4e8e\u4e34\u5e8a\u4e00\u671f\uff0c\u7528\u4e8e\u6cbb\u7597\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u708e\u3002TERN-101\u6700\u521d\u7531\u793c\u6765\uff08Eli Lilly &amp; Company\uff09\u7814\u53d1\uff0c\u540e\u4e8e2018\u5e744\u6708\u6388\u6743\u7ed9\u62d3\u81fb\uff08Terns Pharmaceuticals\uff09\u3002\u7b14\u8005\u6839\u636e\u641c\u7d22\u793c\u6765FXR\u7684\u4e13\u5229\u5206\u6790\uff0cTERN-101\u6781\u6709\u53ef\u80fd\u662f\u975e\u753e\u4f53\u7c7bFXR\u6fc0\u52a8\u5242\u3002\u4f46\u7531\u4e8e\u7f3a\u4e4f\u8db3\u591f\u7684\u751f\u7269\u5b66\u548c\u836f\u5b66\u4fe1\u606f\uff0c\u96be\u4ee5\u5224\u65ad\u5177\u4f53\u7ed3\u6784\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"color: rgb(0, 128, 255);\"><strong><span style=\"font-size: 15px;\">MET-409<\/span><\/strong><\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/1-1554966071.jpeg\" alt=\"\u540e\u5965\u8d1d\u80c6\u9178\u65f6\u4ee3\uff1a\u76d8\u70b9\u975e\u753e\u4f53FXR\u6fc0\u52a8\u5242\" title=\"\u540e\u5965\u8d1d\u80c6\u9178\u65f6\u4ee3\uff1a\u76d8\u70b9\u975e\u753e\u4f53FXR\u6fc0\u52a8\u5242\"  \/><\/p>\n<p style=\"line-height: normal;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">MET-409\u662fMetacrine\u7814\u53d1\u7684\u4e00\u79cd\u53e3\u670d\u975e\u753e\u4f53FXR\u6fc0\u52a8\u5242\uff0c\u62df\u7528\u4e8e\u6cbb\u7597\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\uff0c\u80a0\u6613\u6fc0\u7efc\u5408\u5f81\u4f34\u8179\u6cfb\uff08IBS-D\uff09\u548c\u708e\u6027\u80a0\u75c5\uff08IBD\uff09\u3002\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u4e34\u5e8a\u4e00\u671f\u8bd5\u9a8c\u3002\u4ece\u4e13\u5229\u4e0a\u5206\u6790\uff0cMET-409\u5c5e\u4e8e\u4e00\u7c7bN-\u82b3\u57fa\u9170\u80fa\u5316\u5408\u7269\u3002<\/span><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<p style=\"line-height: 1.75em;text-align: center;\"><span style=\"color: rgb(0, 128, 255);\"><strong><span style=\"font-size: 15px;\">EDP-305<\/span><\/strong><\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\"><br  \/><\/span><\/p>\n<p style=\"text-align: center;\"><img class=\"\"       style=\"\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/8-1554966071.jpeg\" alt=\"\u540e\u5965\u8d1d\u80c6\u9178\u65f6\u4ee3\uff1a\u76d8\u70b9\u975e\u753e\u4f53FXR\u6fc0\u52a8\u5242\" title=\"\u540e\u5965\u8d1d\u80c6\u9178\u65f6\u4ee3\uff1a\u76d8\u70b9\u975e\u753e\u4f53FXR\u6fc0\u52a8\u5242\"  \/><\/p>\n<p style=\"line-height: normal;\"><br  \/><\/p>\n<p style=\"line-height: 1.75em;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">EDP-305\uff0c\u7ed3\u6784\u672a\u516c\u5f00\uff0c\u4f46\u4ece\u4e13\u5229\u5206\u6790\u770b\u5e94\u5c5e\u4e8e\u5f02\u5641\u5511\u7c7b\u5316\u5408\u7269\u3002\u7531Enanta\u7814\u53d1\uff0c2017\u5e741\u67084\u65e5\u83b7\u5f97\u7f8e\u56fdFDA\u5feb\u901f\u901a\u9053\u8ba4\u5b9a\uff0c\u5904\u4e8e\u4e34\u5e8a\u4e8c\u671f\uff0c\u7528\u4e8e\u6cbb\u7597\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u75c5\u548c\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u3002<\/span><\/p>\n<p style=\"line-height: normal;\"><span style=\"font-size: 15px;color: rgb(0, 0, 0);\">&nbsp;<\/span><\/p>\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;\">\n<section class=\"_135editor\"   style=\"border-width: 0px;border-style: none;border-color: initial;box-sizing: border-box;\">\n<section style=\"width:100%;margin:20px auto;\" >\n<section   style=\"background: rgb(214, 226, 227);border-radius: 10px;padding-top: 10px;box-sizing: border-box;\">\n<section style=\"border-width: 5px;border-style: solid;border-color: rgb(199, 213, 230);border-radius: 10px;background: rgb(254, 254, 254);padding: 10px;box-sizing: border-box;\">\n<section style=\"display: flex;justify-content: space-between;align-items: center;transform: scaleY(-1);-webkit-transform: scaleY(-1);-moz-transform: scaleY(-1);-ms-transform: scaleY(-1);-o-transform: scaleY(-1);\">\n<section style=\"width: 1.6em;height: 1.6em;border-bottom: 2px dashed rgb(199, 213, 230);border-left: 2px dashed rgb(199, 213, 230);border-right: none;border-top: 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[&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":82438,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/82437"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=82437"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/82437\/revisions"}],"predecessor-version":[{"id":82446,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/82437\/revisions\/82446"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/82438"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=82437"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=82437"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=82437"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}