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fill=\"rgb(1,134,193)\" style=\"box-sizing: border-box;\"><\/path><path d=\"M83.29,32.4l18.61-15.61c-4.16-2.38-8.98-3.75-14.12-3.75c-0.48,0-0.96,0.01-1.44,0.04c0.99-4.68,4.15-8.97,7.04-12.78     c0.14-0.18-0.11-0.4-0.27-0.24c0,0-16.7,7.18-26.32,20.5L83.29,32.4z\" fill=\"rgb(1,134,193)\" style=\"box-sizing: border-box;\"><\/path><\/g><\/g><\/g><\/svg><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: -140px;margin-right: 0%;margin-left: 0%;transform: translate3d(1px, 0px, 0px);box-sizing: border-box;\">\n<section style=\"line-height: 1.8;padding-right: 15px;padding-left: 15px;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u836f\u7269\u5f00\u53d1\u662f\u4e00\u4e2a\u9010\u6b65\u9012\u8fdb\u7684\u8fc7\u7a0b\uff0c\u5bf9\u52a8\u7269\u548c\u4eba\u4f53\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u7684\u7814\u7a76\u8bc4\u4ef7\u968f\u7740\u5f00\u53d1\u8fdb\u7a0b\u4e0d\u65ad\u5f80\u524d\u63a8\u8fdb\u3002\u751f\u6b96\u6bd2\u6027\u662f\u836f\u7269\u975e\u4e34\u5e8a\u5b89\u5168\u6027\u8bc4\u4ef7\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\u3002\u5728\u836f\u7269\u5f00\u53d1\u7684\u8fc7\u7a0b\u4e2d\uff0c\u901a\u8fc7\u52a8\u7269\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u6765\u53cd\u6620\u6240\u7814\u7a76\u836f\u7269\u5bf9\u54fa\u4e73\u52a8\u7269\u529f\u80fd\u548c\u53d1\u80b2\u8fc7\u7a0b\u7684\u5f71\u54cd\uff0c\u9884\u6d4b\u5176\u53ef\u80fd\u4ea7\u751f\u7684\u751f\u6b96\u7ec6\u80de\u3001\u53d7\u5b55\u3001\u598a\u5a20\u3001\u5206\u5a29\u3001\u54fa\u80b2\u4e73\u7b49\u4eb2\u4ee3\u751f\u6b96\u673a\u80fd\u7684\u4e0d\u826f\u5f71\u54cd\uff0c\u4ee5\u53ca\u5bf9\u5b50\u4ee3\u80da\u80ce-\u80ce\u4ed4\u53d1\u80b2\u3001\u51fa\u751f\u540e\u53d1\u80b2\u7684\u4e0d\u826f\u5f71\u54cd\uff0c\u4ece\u800c\u5728\u9650\u5b9a\u4e34\u5e8a\u8bd5\u9a8c\u53d7\u8bd5\u8005\u8303\u56f4\u3001\u964d\u4f4e\u4e34\u5e8a\u8bd5\u9a8c\u53d7\u8bd5\u8005\u548c\u836f\u54c1\u4e0a\u5e02\u540e\u4f7f\u7528\u4eba\u7fa4\u7684\u7528\u836f\u98ce\u9669\u65b9\u9762\u53d1\u6325\u91cd\u8981\u4f5c<span style=\"font-family:\u5b8b\u4f53;\">\u7528<\/span><sup><span style=\"font-size: 16px;vertical-align: super;\">[1<span style=\"font-family:\u5b8b\u4f53;\">\u3001<\/span><span style=\"font-family:Times New Roman;\">2]<\/span><\/span><\/sup><span style=\"font-family:\u5b8b\u4f53;\">\u3002<\/span><\/p>\n<p><span style=\"font-size:16px;\"><span style=\"font-family:\u5b8b\u4f53;\"><\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin: 10px 0%;box-sizing: border-box;\">\n<section style=\"display: inline-block;width: 95%;vertical-align: top;background-color: rgb(255, 255, 255);box-shadow: rgb(189, 189, 189) 0px 0px 4px;border-width: 0px;border-radius: 5px;border-style: none;border-color: rgb(62, 62, 62);overflow: hidden;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-shadow: rgb(0, 0, 0) 0px 0px 0px;box-sizing: border-box;\"><img class=\"raw-image\"     style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/0-1555469782.jpeg\" alt=\"ICH M3\uff08R2\uff09\u5b9e\u65bd\u4e2d\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u9700\u8981\u5173\u6ce8\u7684\u95ee\u9898\" title=\"ICH M3\uff08R2\uff09\u5b9e\u65bd\u4e2d\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u9700\u8981\u5173\u6ce8\u7684\u95ee\u9898\"  \/><\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"width: 100%;height: 5px;background-image: linear-gradient(to right, rgb(202, 112, 30), rgb(245, 175, 25));box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;box-shadow: rgb(0, 0, 0) 0px 0px 0px;padding: 20px 10px;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 15px;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"font-size: 16px;\">\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u5e38\u89c4\u91c7\u7528\u7684\u8bd5\u9a8c\u65b9\u6848\u4e3a\u4e09\u6bb5\u5f0f\u8bd5\u9a8c\u65b9\u6848\uff0c\u5373\u751f\u80b2\u529b\u4e0e\u65e9\u671f\u80da\u80ce\u53d1\u80b2\u6bd2\u6027\u8bd5\u9a8c\uff08\u2160\u6bb5\uff09\u3001\u80da\u80ce-\u80ce\u4ed4\u53d1\u80b2\u6bd2\u6027\u8bd5\u9a8c\uff08\u2161\u6bb5\uff09\u3001\u56f4\u4ea7\u671f\u6bd2\u6027\u8bd5\u9a8c\uff08\u2162\u671f\uff09\u3002<\/span><span style=\"font-size: 16px;\">\u4e09\u6bb5\u5f0f\u8bd5\u9a8c\u901a\u8fc7\u5728\u4e0d\u540c\u9636\u6bb5\u7684\u7ed9\u836f\u548c\u4e0d\u540c\u7684\u89c2\u5bdf\u6307\u6807\uff0c\u6765\u5168\u9762\u89c2\u5bdf\u5bf9\u751f\u6b96\u6574\u4e2a\u8fc7\u7a0b\u7684\u5f71\u54cd\u3002<\/span><span style=\"font-size: 16px;\">\u5728\u836f\u7269\u5f00\u53d1\u7684\u4e0d\u540c\u9636\u6bb5\uff0c\u57fa\u4e8e\u98ce\u9669\u7684\u5927\u5c0f\u53ef\u5206\u9636\u6bb5\u63d0\u4f9b\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u8d44\u6599\u4ee5\u652f\u6301\u4e0d\u540c\u9636\u6bb5\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"font-size: 16px;\">\u5173\u4e8e\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u7684\u9636\u6bb5\u6027\u8981\u6c42\uff0c\u6211\u56fd\u4e8e2006\u5e74\u53d1\u5e03\u7684\u300a\u836f\u7269\u751f\u6b96\u6bd2\u6027\u7814\u7a76\u6280\u672f\u6307\u5bfc\u539f\u5219\u300b\u4e2d\uff0c\u4ece\u4fdd\u969c\u53d7\u8bd5\u8005\u5b89\u5168\u6027\u89d2\u5ea6\u51fa\u53d1\uff0c\u7ed3\u5408\u6211\u56fd\u4e34\u5e8a\u7814\u7a76\u98ce\u9669\u63a7\u5236\u53ca\u975e\u4e34\u5e8a\u7814\u7a76\u98ce\u9669\u8bc6\u522b\u7684\u7279\u70b9\uff0c\u8981\u6c42\uff1a<\/span><span style=\"font-size: 16px;\">\u901a\u5e38\u60c5\u51b5\u4e0b\u5728\u2160\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5f00\u59cb\u524d\u63d0\u4f9b\u5b8c\u6574\u7684\u2160\u6bb5\u3001\u2161\u6bb5\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u8d44\u6599\uff0c\u4ee5\u671f\u5728\u4e34\u5e8a\u7814\u7a76\u5f00\u59cb\u524d\u5c3d\u53ef\u80fd\u4e86\u89e3\u53d7\u8bd5\u7269\u5bf9\u96cc\u96c4\u52a8\u7269\u751f\u6b96\u80fd\u529b\u3001\u751f\u6b96\u5668\u5b98\u3001\u751f\u6b96\u7ec6\u80de\u4ee5\u53ca\u80da\u80ce\u53d1\u80b2\u7684\u5f71\u54cd\uff1b<\/span><span style=\"font-size: 16px;\">\u56f4\u4ea7\u671f\u6bd2\u6027\u8bd5\u9a8c\u8d44\u6599\u53ef\u5728\u4e0a\u5e02\u7533\u8bf7\u65f6\u63d0\u4f9b\u3002<\/span><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"font-size: 16px;\">\u4e2d\u56fd\u4e8e2017\u5e74\u52a0\u5165ICH\u540e\uff0c\u5bf9\u7533\u8bf7\u4e34\u5e8a\u8bd5\u9a8c\u548c\u4e0a\u5e02\u7684\u751f\u6b96\u6bd2\u6027\u7684\u9636\u6bb5\u6027\u8981\u6c42\u53ef\u53c2\u8003\u7167ICH&nbsp;M3\uff08R2\uff09\u6307\u5bfc\u539f\u5219\uff0c\u57fa\u4e8e\u751f\u6b96\u6bd2\u6027\u62c5\u5fe7\u7684\u5927\u5c0f\uff0c\u4e0e\u4e34\u5e8a\u8bd5\u9a8c\u8fc7\u7a0b\u4e2d\u4e25\u683c\u7684\u751f\u6b96\u6bd2\u6027\u98ce\u9669\u63a7\u5236\u63aa\u65bd\uff0c\u5206\u9636\u6bb5\u63d0\u4f9b\u652f\u6301\u76f8\u5e94\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u7684\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u3002<\/span><span style=\"font-size: 16px;\">\u8fd9\u5176\u4e2d\uff0c\u751f\u6b96\u6bd2\u6027\u7684\u62c5\u5fe7\u4e0e\u62df\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\u7684\u671f\u9650\u3001\u6837\u672c\u91cf\u548c\u5165\u7ec4\u53d7\u8bd5\u8005\u4eba\u7fa4\u7279\u70b9\u6709\u5173\u3002<\/span><span style=\"font-size: 16px;\">\u672c\u6587\u9610\u8ff0ICH&nbsp;M3\uff08R2\uff09\u4e2d\u652f\u6301\u4e0d\u540c\u836f\u7269\u5f00\u53d1\u9636\u6bb5\u7684\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u8981\u6c42\uff0c\u4ee5\u53ca\u5728\u8be5\u6307\u5bfc\u539f\u5219\u5b9e\u65bd\u8fc7\u7a0b\u4e2d\u9700\u8981\u5173\u6ce8\u7684\u95ee\u9898\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;transform: translate3d(-2px, 0px, 0px);-webkit-transform: translate3d(-2px, 0px, 0px);-moz-transform: translate3d(-2px, 0px, 0px);-o-transform: translate3d(-2px, 0px, 0px);margin: 10px 0%;box-sizing: border-box;\">\n<section style=\"display: inline-block;min-width: 10%;max-width: 100%;vertical-align: top;background-color: rgb(255, 202, 0);box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin: 5px 0% -5px;transform: translate3d(5px, 0px, 0px);-webkit-transform: translate3d(5px, 0px, 0px);-moz-transform: translate3d(5px, 0px, 0px);-o-transform: translate3d(5px, 0px, 0px);box-sizing: border-box;\">\n<section style=\"display: inline-block;min-width: 10%;max-width: 100%;vertical-align: top;border-style: solid;border-width: 8px 1px 1px;border-radius: 0px;border-color: rgb(62, 62, 62);background-color: rgb(255, 255, 255);padding-right: 8px;padding-left: 8px;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: left;padding-right: 8px;padding-left: 8px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u652f\u6301\u4e0d\u540c\u836f\u7269\u5f00\u53d1\u9636\u6bb5\u7684<\/strong><\/p>\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u8981<\/strong><strong><span style=\"line-height: 150%;font-family: \u5b8b\u4f53;\">\u6c42<\/span><\/strong><span style=\"font-size: 14px;\"><sup><span style=\"line-height: 150%;vertical-align: super;\">[3]<\/span><\/sup><\/span><sup><span style=\"line-height: 150%;font-size: 16px;vertical-align: super;\"><\/span><\/sup><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">ICH&nbsp;M3\uff08R2\uff09\u4e2d\u89c4\u5b9a\u9488\u5bf9\u4e0d\u540c\u7684\u5f00\u53d1\u9636\u6bb5\u548c\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u62df\u7eb3\u5165\u7684\u4eba\u7fa4\uff0c\u5728\u9002\u5f53\u7684\u65f6\u95f4\u8fdb\u884c\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 8%;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;width: 50%;box-sizing: border-box;\"><img class=\"raw-image\"     style=\"vertical-align: middle;width: 100%;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/3-1555469782.png\" alt=\"ICH M3\uff08R2\uff09\u5b9e\u65bd\u4e2d\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u9700\u8981\u5173\u6ce8\u7684\u95ee\u9898\" title=\"ICH M3\uff08R2\uff09\u5b9e\u65bd\u4e2d\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u9700\u8981\u5173\u6ce8\u7684\u95ee\u9898\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 92%;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 12px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u7537\u6027\u53d7\u8bd5\u8005<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5728\u91cd\u590d\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c\u4e2d\u5bf9\u96c4\u6027\u751f\u6b96\u5668\u5b98\u8fdb\u884c\u4e86\u8be6\u7ec6\u68c0\u67e5\uff08\u5305\u62ec\u5168\u9762\u7684\u7ec4\u7ec7\u75c5\u7406\u5b66\u68c0\u67e5\uff09\uff0c\u96c4\u6027\u751f\u80b2\u529b\u8bd5\u9a8c\u5b8c\u6210\u524d\uff0c\u7537\u6027\u53d7\u8bd5\u8005\u53ef\u4ee5\u7eb3\u5165\u2160\u3001\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u96c4\u6027\u751f\u80b2\u529b\u8bd5\u9a8c\u5e94\u5728\u5927\u89c4\u6a21\u6216\u957f\u671f\u7684\u4e34\u5e8a\u8bd5\u9a8c\u5f00\u59cb\u524d\u5b8c\u6210\u3002\u5927\u89c4\u6a21\u6216\u957f\u671f\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u4e8eIII\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u89c6\u4e34\u5e8a\u65b9\u6848\u786e\u5b9a\uff0c\u5982\u5927\u4e8e150\u4eba\u6216\u65f6\u95f4\u8d85\u8fc73\u4e2a\u6708\u3002<\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 8%;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;width: 50%;box-sizing: border-box;\"><img class=\"raw-image\"     style=\"vertical-align: middle;width: 100%;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/7-1555469782.png\" alt=\"ICH M3\uff08R2\uff09\u5b9e\u65bd\u4e2d\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u9700\u8981\u5173\u6ce8\u7684\u95ee\u9898\" title=\"ICH M3\uff08R2\uff09\u5b9e\u65bd\u4e2d\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u9700\u8981\u5173\u6ce8\u7684\u95ee\u9898\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 92%;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 12px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u5973\u6027\u53d7\u8bd5\u8005<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"width: 8px;height: 8px;border-radius: 50%;margin: auto;background-color: rgb(255, 255, 255);border-width: 1px;border-style: solid;border-color: rgb(119, 95, 159);box-sizing: border-box;\"><\/section>\n<section style=\"width: 22px;margin-top: -5px;margin-right: auto;margin-left: auto;box-sizing: border-box;\">\n<section style=\"height: 20px;transform: rotate(45deg);-webkit-transform: rotate(45deg);-moz-transform: rotate(45deg);-o-transform: rotate(45deg);transform-origin: left center 0px;-webkit-transform-origin: left center 0px;-moz-transform-origin: left center 0px;-o-transform-origin: left center 0px;float: left;border-left: 1px solid rgb(119, 95, 159);border-top-color: rgb(119, 95, 159);border-right-color: rgb(119, 95, 159);border-bottom-color: rgb(119, 95, 159);box-sizing: border-box;\"><\/section>\n<section style=\"height: 20px;border-left: 1px solid rgb(119, 95, 159);transform: rotate(-45deg);-webkit-transform: rotate(-45deg);-moz-transform: rotate(-45deg);-o-transform: rotate(-45deg);transform-origin: right center 0px;-webkit-transform-origin: right center 0px;-moz-transform-origin: right center 0px;-o-transform-origin: right center 0px;float: right;border-top-color: rgb(119, 95, 159);border-right-color: rgb(119, 95, 159);border-bottom-color: rgb(119, 95, 159);box-sizing: border-box;\"><\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<section style=\"border-width: 1px;border-style: solid;border-color: rgb(119, 95, 159);display: inline-block;vertical-align: top;margin-top: -3px;border-radius: 5px;padding: 2px 8px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u65e0\u751f\u80b2\u53ef\u80fd\u7684\u5987\u5973<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;\">\u65e0\u751f\u80b2\u53ef\u80fd\u5987\u5973\u5b9a\u4e49\u4e3a\u7edd\u80b2\u6216\u7edd\u7ecf\u540e\u5987\u5973\u3002\u7edd\u7ecf\u540e\u5b9a\u4e49\u4e3a\u5728\u65e0\u66ff\u4ee3\u533b\u7597\u63aa\u65bd\u7684\u60c5\u51b5\u4e0b\u505c\u7ecf12\u4e2a\u6708\u3002<\/span><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5982\u679c\u5728\u91cd\u590d\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c\u4e2d\u5bf9\u96cc\u6027\u751f\u6b96\u5668\u5b98\u8fdb\u884c\u8be6\u7ec6\u68c0\u67e5\uff0c\u65e0\u751f\u80b2\u53ef\u80fd\u5987\u5973\u5728\u7f3a\u5c11\u52a8\u7269\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u7684\u60c5\u51b5\u4e0b\u53ef\u7eb3\u5165\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"width: 8px;height: 8px;border-radius: 50%;margin: auto;background-color: rgb(255, 255, 255);border-width: 1px;border-style: solid;border-color: rgb(119, 95, 159);box-sizing: border-box;\"><\/section>\n<section style=\"width: 22px;margin-top: -5px;margin-right: auto;margin-left: auto;box-sizing: border-box;\">\n<section style=\"height: 20px;transform: rotate(45deg);-webkit-transform: rotate(45deg);-moz-transform: rotate(45deg);-o-transform: rotate(45deg);transform-origin: left center 0px;-webkit-transform-origin: left center 0px;-moz-transform-origin: left center 0px;-o-transform-origin: left center 0px;float: left;border-left: 1px solid rgb(119, 95, 159);border-top-color: rgb(119, 95, 159);border-right-color: rgb(119, 95, 159);border-bottom-color: rgb(119, 95, 159);box-sizing: border-box;\"><\/section>\n<section style=\"height: 20px;border-left: 1px solid rgb(119, 95, 159);transform: rotate(-45deg);-webkit-transform: rotate(-45deg);-moz-transform: rotate(-45deg);-o-transform: rotate(-45deg);transform-origin: right center 0px;-webkit-transform-origin: right center 0px;-moz-transform-origin: right center 0px;-o-transform-origin: right center 0px;float: right;border-top-color: rgb(119, 95, 159);border-right-color: rgb(119, 95, 159);border-bottom-color: rgb(119, 95, 159);box-sizing: border-box;\"><\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<section style=\"border-width: 1px;border-style: solid;border-color: rgb(119, 95, 159);display: inline-block;vertical-align: top;margin-top: -3px;border-radius: 5px;padding: 2px 8px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u598a\u5a20\u5987\u5973<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;\">\u5728\u598a\u5a20\u5987\u5973\u7eb3\u5165\u4e34\u5e8a\u8bd5\u9a8c\u524d\uff0c\u5404\u9879\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u548c\u9057\u4f20\u6bd2\u6027\u6807\u51c6\u8bd5\u9a8c\u7ec4\u5408\u5747\u5e94\u5b8c\u6210\u3002\u53e6\u5916\uff0c\u8fd8\u5e94\u5bf9\u836f\u7269\u4ee5\u5f80\u4eba\u4f53\u66b4\u9732\u7684\u5b89\u5168\u6027\u6570\u636e\u8fdb\u884c\u8bc4\u4ef7\u3002<\/span><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"width: 8px;height: 8px;border-radius: 50%;margin: auto;background-color: rgb(255, 255, 255);border-width: 1px;border-style: solid;border-color: rgb(119, 95, 159);box-sizing: border-box;\"><\/section>\n<section style=\"width: 22px;margin-top: -5px;margin-right: auto;margin-left: auto;box-sizing: border-box;\">\n<section style=\"height: 20px;transform: rotate(45deg);-webkit-transform: rotate(45deg);-moz-transform: rotate(45deg);-o-transform: rotate(45deg);transform-origin: left center 0px;-webkit-transform-origin: left center 0px;-moz-transform-origin: left center 0px;-o-transform-origin: left center 0px;float: left;border-left: 1px solid rgb(119, 95, 159);border-top-color: rgb(119, 95, 159);border-right-color: rgb(119, 95, 159);border-bottom-color: rgb(119, 95, 159);box-sizing: border-box;\"><\/section>\n<section style=\"height: 20px;border-left: 1px solid rgb(119, 95, 159);transform: rotate(-45deg);-webkit-transform: rotate(-45deg);-moz-transform: rotate(-45deg);-o-transform: rotate(-45deg);transform-origin: right center 0px;-webkit-transform-origin: right center 0px;-moz-transform-origin: right center 0px;-o-transform-origin: right center 0px;float: right;border-top-color: rgb(119, 95, 159);border-right-color: rgb(119, 95, 159);border-bottom-color: rgb(119, 95, 159);box-sizing: border-box;\"><\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<section style=\"border-width: 1px;border-style: solid;border-color: rgb(119, 95, 159);display: inline-block;vertical-align: top;margin-top: -3px;border-radius: 5px;padding: 2px 8px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u6709\u751f\u80b2\u53ef\u80fd\u7684\u5987\u5973\uff08WOCBP\uff09<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;\">\u5bf9\u4e8e\u6709\u751f\u80b2\u53ef\u80fd\u7684\u5987\u5973\uff0c\u5728\u6f5c\u5728\u98ce\u9669\u4e0e\u83b7\u76ca\u4fe1\u606f\u83b7\u5f97\u4e4b\u524d\uff0c\u5bf9\u80da\u80ce\u6216\u80ce\u513f\u7684\u975e\u9884\u671f\u66b4\u9732\u5177\u6709\u8f83\u9ad8\u6c34\u5e73\u7684\u62c5\u5fe7\u3002\u5f53\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7eb3\u5165WOCBP\u65f6\uff0c\u5bf9\u80da\u80ce\u6216\u80ce\u513f\u975e\u9884\u671f\u66b4\u9732\u98ce\u9669\u8fdb\u884c\u8868\u5f81\u5e76\u5c06\u98ce\u9669\u964d\u81f3\u6700\u5c0f\u5316\u975e\u5e38\u91cd\u8981\u3002<\/span><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: middle;box-sizing: border-box;\">\n<section style=\"height: 5px;line-height: 5px;box-sizing: border-box;\">\n<section style=\"padding-right: 8px;padding-left: 3px;display: inline-block;vertical-align: bottom;background-color: rgb(255, 255, 255);box-sizing: border-box;\"><span style=\"width: 5px;height: 5px;float: left;border-radius: 50%;margin-left: 4px;background-color: rgb(51, 66, 159);box-sizing: border-box;\"><\/span><span style=\"width: 5px;height: 5px;float: left;border-radius: 50%;margin-left: 4px;background-color: rgb(51, 66, 159);box-sizing: border-box;\"><\/span><span style=\"width: 5px;height: 5px;float: left;border-radius: 50%;margin-left: 4px;background-color: rgb(51, 66, 159);box-sizing: border-box;\"><\/span><span style=\"width: 5px;height: 5px;float: left;border-radius: 50%;margin-left: 4px;background-color: rgb(51, 66, 159);box-sizing: border-box;\"><\/span><\/p>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<section style=\"border-top: 1px solid rgb(210, 210, 210);border-bottom: 1px solid rgb(210, 210, 210);margin-top: -3px;margin-bottom: -3px;padding: 3px 6px;color: rgb(51, 66, 159);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u2161\u6bb5\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c<\/p>\n<\/section>\n<section style=\"height: 5px;line-height: 5px;box-sizing: border-box;\">\n<section style=\"padding-right: 8px;padding-left: 3px;display: inline-block;vertical-align: top;background-color: rgb(255, 255, 255);box-sizing: border-box;\"><span style=\"width: 5px;height: 5px;float: left;border-radius: 50%;margin-left: 4px;background-color: rgb(51, 66, 159);box-sizing: border-box;\"><\/span><span style=\"width: 5px;height: 5px;float: left;border-radius: 50%;margin-left: 4px;background-color: rgb(51, 66, 159);box-sizing: border-box;\"><\/span><span style=\"width: 5px;height: 5px;float: left;border-radius: 50%;margin-left: 4px;background-color: rgb(51, 66, 159);box-sizing: border-box;\"><\/span><span style=\"width: 5px;height: 5px;float: left;border-radius: 50%;margin-left: 4px;background-color: rgb(51, 66, 159);box-sizing: border-box;\"><\/span><\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><br  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;\">\u4e3a\u4f7f\u80da\u80ce\u6216\u80ce\u513f\u98ce\u9669\u964d\u81f3\u6700\u4f4e\uff0c\u6709\u4e24\u79cd\u65b9\u6cd5\u3002\u7b2c\u4e00\u79cd\u65b9\u6cd5\u662f\u8fdb\u884c\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u4ee5\u8868\u5f81\u836f\u7269\u672c\u8eab\u7684\u56fa\u6709\u98ce\u9669\uff0c\u5e76\u5728\u4e34\u5e8a\u8bd5\u9a8cWOCBP\u7684\u66b4\u9732\u8fc7\u7a0b\u4e2d\u91c7\u53d6\u9002\u5f53\u7684\u9632\u63a7\u63aa\u65bd\u3002\u7b2c\u4e8c\u79cd\u65b9\u6cd5\u662f\u4e34\u5e8a\u8bd5\u9a8c\u8fc7\u7a0b\u4e2d\u901a\u8fc7\u91c7\u53d6\u907f\u5b55\u63aa\u65bd\u4ee5\u63a7\u5236\u98ce\u9669\uff0c\u6b64\u65f6\u80da\u80ce-\u80ce\u4ed4\u53d1\u80b2\u5f71\u54cd\u7684\u8bc4\u4ef7\u53ef\u5ef6\u8fdf\u81f3\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u524d\u5b8c\u6210\uff08\u89c6\u4e34\u5e8a\u8bd5\u9a8c\u89c4\u6a21\u548c\u65f6\u95f4\uff09\u3002<\/span><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br  \/><\/p>\n<p style=\"white-space: normal;box-sizing: 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style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5728\u67d0\u4e9b\u7279\u6b8a\u60c5\u51b5\u4e0b\uff0c\u5728\u672a\u8fdb\u884c\u52a8\u7269\u53d1\u80b2\u6bd2\u6027\u8bd5\u9a8c\uff08\u5982\u80da\u80ce-\u80ce\u4ed4\u8bd5\u9a8c\uff09\u65f6\uff0cWOCBP\u4e5f\u53ef\u7eb3\u5165\u65e9\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u4e00\u79cd\u60c5\u51b5\u662f\u5728\u77ed\u671f\uff08\u59822\u5468\uff09\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u52a0\u5f3a\u598a\u5a20\u98ce\u9669\u63a7\u5236\u3002\u53e6\u4e00\u79cd\u60c5\u51b5\u662f\u75be\u75c5\u5728\u5973\u6027\u4e2d\u9ad8\u53d1\uff0c\u4e0d\u7eb3\u5165WOCBP\u65e0\u6cd5\u6709\u6548\u5730\u8fbe\u5230\u4e34\u5e8a\u8bd5\u9a8c\u76ee\u7684\uff0c\u4e14\u6709\u8db3\u591f\u7684\u9884\u9632\u63aa\u65bd\u4ee5\u907f\u514d\u598a\u5a20\uff08\u5177\u4f53\u63aa\u65bd\u89c1\u4e0a\u8ff0\uff09\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5728\u7f3a\u4e4f\u52a8\u7269\u53d1\u80b2\u6bd2\u6027\u8bd5\u9a8c\u7684\u60c5\u51b5\u4e0b\uff0c\u4e34\u5e8a\u8bd5\u9a8c\u7eb3\u5165WOCBP\uff0c\u8fd8\u9700\u8003\u8651\u7684\u5176\u4ed6\u56e0\u7d20\u5305\u62ec\u5bf9\u836f\u7269\u4f5c\u7528\u673a\u5236\u3001\u836f\u7269\u7c7b\u578b\u3001\u836f\u7269\u5728\u80ce\u513f\u66b4\u9732\u7684\u7a0b\u5ea6\uff0c\u6216\u5728\u5408\u9002\u7684\u52a8\u7269\u6a21\u578b\u4e2d\u8fdb\u884c\u53d1\u80b2\u6bd2\u6027\u8bd5\u9a8c\u7684\u96be\u5ea6\u7684\u8ba4\u8bc6\u3002\u4f8b\u5982\uff0c\u6839\u636e\u5f53\u524d\u7684\u79d1\u5b66\u8ba4\u8bc6\uff0c\u5355\u514b\u9686\u6297\u4f53\u5728\u4eba\u7c7b\u7684\u5668\u5b98\u53d1\u751f\u671f\u7ed9\u836f\uff0c\u80da\u80ce-\u80ce\u513f\u7684\u66b4\u9732\u91cf\u8f83\u4f4e\uff0c\u56e0\u6b64\u53d1\u80b2\u6bd2\u6027\u8bd5\u9a8c\u53ef\u5728\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u671f\u95f4\u8fdb\u884c\uff0c\u5728\u7533\u8bf7\u4e0a\u5e02\u65f6\u5e94\u63d0\u4ea4\u5b8c\u6574\u7684\u8bd5\u9a8c\u62a5\u544a\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u901a\u5e38\u60c5\u51b5\u4e0b\uff0c\u82e5\u80fd\u83b7\u5f97\u5728\u4e24\u79cd\u52a8\u7269\u79cd\u5c5e\u4e2d\u8fdb\u884c\u7684\u9002\u5f53\u7684\u521d\u6b65\u751f\u6b96\u6bd2\u6027\u6570\u636e\uff0c\u4e14\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u91c7\u53d6\u4e25\u683c\u7684\u907f\u5b55\u63aa\u65bd\uff0c\u5728\u6700\u7ec8\u7684\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u5b8c\u6210\u4e4b\u524d\uff0c\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u53ef\u7eb3\u5165WOCBP\uff08\u5c0f\u4e8e150\u4eba\uff09\u8fdb\u884c\u76f8\u5bf9\u77ed\u671f\uff08\u4e0d\u8d85\u8fc73\u4e2a\u6708\uff09\u7684\u7814\u7a76\u6027\u7ed9\u836f\u3002\u5141\u8bb8WOCBP\u8fdb\u884c\u8be5\u79cd\u89c4\u6a21\u548c\u7ed9\u836f\u671f\u9650\u7684\u8bd5\u9a8c\uff0c\u662f\u57fa\u4e8e\u6b64\u79cd\u89c4\u6a21\u548c\u671f\u9650\u7684\u4e25\u683c\u63a7\u5236\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u53d7\u8bd5\u8005\u7684\u598a\u5a20\u6982\u7387\u975e\u5e38\u4f4e\uff0c\u800c\u8bbe\u8ba1\u5408\u7406\u7684\u521d\u6b65\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u80fd\u591f\u68c0\u51fa\u4e34\u5e8a\u8bd5\u9a8c\u7eb3\u5165WOCBP\u65f6\u53ef\u5f15\u8d77\u62c5\u5fe7\u7684\u5927\u90e8\u5206\u53d1\u80b2\u6bd2\u6027\u53d1\u73b0\u3002WOCBP\u7684\u6837\u672c\u91cf\u548c\u8bd5\u9a8c\u671f\u9650\uff0c\u53ef\u53d7\u5230\u6539\u53d8\u598a\u5a20\u7387\u7684\u4eba\u7fa4\u7279\u5f81\uff08\u5982\u5e74\u9f84\u3001\u75be\u75c5\uff09\u7684\u5f71\u54cd\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: middle;box-sizing: border-box;\">\n<section style=\"height: 5px;line-height: 5px;box-sizing: border-box;\">\n<section style=\"padding-right: 8px;padding-left: 3px;display: inline-block;vertical-align: bottom;background-color: rgb(255, 255, 255);box-sizing: border-box;\"><span style=\"width: 5px;height: 5px;float: left;border-radius: 50%;margin-left: 4px;background-color: rgb(51, 66, 159);box-sizing: border-box;\"><\/span><span style=\"width: 5px;height: 5px;float: left;border-radius: 50%;margin-left: 4px;background-color: rgb(51, 66, 159);box-sizing: border-box;\"><\/span><span style=\"width: 5px;height: 5px;float: left;border-radius: 50%;margin-left: 4px;background-color: rgb(51, 66, 159);box-sizing: border-box;\"><\/span><span style=\"width: 5px;height: 5px;float: left;border-radius: 50%;margin-left: 4px;background-color: rgb(51, 66, 159);box-sizing: border-box;\"><\/span><\/p>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<section style=\"border-top: 1px solid rgb(210, 210, 210);border-bottom: 1px solid rgb(210, 210, 210);margin-top: -3px;margin-bottom: -3px;padding: 3px 6px;color: rgb(51, 66, 159);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u2160\u6bb5\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c<\/p>\n<\/section>\n<section style=\"height: 5px;line-height: 5px;box-sizing: border-box;\">\n<section style=\"padding-right: 8px;padding-left: 3px;display: inline-block;vertical-align: top;background-color: rgb(255, 255, 255);box-sizing: border-box;\"><span style=\"width: 5px;height: 5px;float: left;border-radius: 50%;margin-left: 4px;background-color: rgb(51, 66, 159);box-sizing: border-box;\"><\/span><span style=\"width: 5px;height: 5px;float: left;border-radius: 50%;margin-left: 4px;background-color: rgb(51, 66, 159);box-sizing: border-box;\"><\/span><span style=\"width: 5px;height: 5px;float: left;border-radius: 50%;margin-left: 4px;background-color: rgb(51, 66, 159);box-sizing: border-box;\"><\/span><span style=\"width: 5px;height: 5px;float: left;border-radius: 50%;margin-left: 4px;background-color: rgb(51, 66, 159);box-sizing: border-box;\"><\/span><\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><span style=\"letter-spacing: 0px;box-sizing: border-box;\">\u5728\u91cd\u590d\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c\u4e2d\u5bf9\u96cc\u6027\u751f\u6b96\u5668\u5b98\u8fdb\u884c\u4e86\u8bc4\u4ef7\u7684\u524d\u63d0\u4e0b\uff0c\u5728\u96cc\u6027\u751f\u80b2\u529b\u8bd5\u9a8c\u8fdb\u884c\u4e4b\u524d\uff0c\u591a\u6b21\u7ed9\u836f\u7684\u2160\u3001\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u53ef\u4ee5\u7eb3\u5165WOCBP\u3002\u4e3a\u652f\u6301\u5927\u89c4\u6a21\u6216\u957f\u671f\u7ed9\u836f\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff08\u5982\u2162\u671f\u8bd5\u9a8c\uff09\u7eb3\u5165WOCBP\uff0c\u5e94\u5b8c\u6210\u4e13\u95e8\u7684\u96cc\u6027\u751f\u80b2\u529b\u8bd5\u9a8c\u3002<\/span><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 10px;margin-bottom: 10px;text-align: center;box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: middle;box-sizing: border-box;\">\n<section style=\"height: 5px;line-height: 5px;box-sizing: border-box;\">\n<section style=\"padding-right: 8px;padding-left: 3px;display: inline-block;vertical-align: bottom;background-color: rgb(255, 255, 255);box-sizing: border-box;\"><span style=\"width: 5px;height: 5px;float: left;border-radius: 50%;margin-left: 4px;background-color: rgb(51, 66, 159);box-sizing: border-box;\"><\/span><span style=\"width: 5px;height: 5px;float: left;border-radius: 50%;margin-left: 4px;background-color: rgb(51, 66, 159);box-sizing: border-box;\"><\/span><span style=\"width: 5px;height: 5px;float: left;border-radius: 50%;margin-left: 4px;background-color: rgb(51, 66, 159);box-sizing: border-box;\"><\/span><span style=\"width: 5px;height: 5px;float: left;border-radius: 50%;margin-left: 4px;background-color: rgb(51, 66, 159);box-sizing: border-box;\"><\/span><\/p>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<section style=\"border-top: 1px solid rgb(210, 210, 210);border-bottom: 1px solid rgb(210, 210, 210);margin-top: -3px;margin-bottom: -3px;padding: 3px 6px;color: rgb(51, 66, 159);box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u2162\u6bb5\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c<\/p>\n<\/section>\n<section style=\"height: 5px;line-height: 5px;box-sizing: border-box;\">\n<section style=\"padding-right: 8px;padding-left: 3px;display: inline-block;vertical-align: top;background-color: rgb(255, 255, 255);box-sizing: border-box;\"><span style=\"width: 5px;height: 5px;float: left;border-radius: 50%;margin-left: 4px;background-color: rgb(51, 66, 159);box-sizing: border-box;\"><\/span><span style=\"width: 5px;height: 5px;float: left;border-radius: 50%;margin-left: 4px;background-color: rgb(51, 66, 159);box-sizing: border-box;\"><\/span><span style=\"width: 5px;height: 5px;float: left;border-radius: 50%;margin-left: 4px;background-color: rgb(51, 66, 159);box-sizing: border-box;\"><\/span><span style=\"width: 5px;height: 5px;float: left;border-radius: 50%;margin-left: 4px;background-color: rgb(51, 66, 159);box-sizing: border-box;\"><\/span><\/section>\n<section style=\"clear: both;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u56f4\u4ea7\u671f\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u5e94\u5728\u7533\u8bf7\u4e0a\u5e02\u65f6\u63d0\u4ea4\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u4f46\u662f\uff0c\u5728\u672a\u91c7\u53d6\u6709\u6548\u907f\u5b55\u63aa\u65bd\u7684WOCBP\u6216\u598a\u5a20\u72b6\u51b5\u4e0d\u660e\u7684\u5987\u5973\u7eb3\u5165\u4e34\u5e8a\u8bd5\u9a8c\u524d\uff0c\u6240\u6709\u96cc\u6027\u52a8\u7269\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u548c\u9057\u4f20\u6bd2\u6027\u6807\u51c6\u8bd5\u9a8c\u7ec4\u5408\u5747\u5e94\u5b8c\u6210\u3002<\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;\"><img class=\"raw-image\"     style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/3-1555469782.jpeg\" alt=\"ICH M3\uff08R2\uff09\u5b9e\u65bd\u4e2d\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u9700\u8981\u5173\u6ce8\u7684\u95ee\u9898\" title=\"ICH M3\uff08R2\uff09\u5b9e\u65bd\u4e2d\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u9700\u8981\u5173\u6ce8\u7684\u95ee\u9898\"  \/><\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;transform: translate3d(-2px, 0px, 0px);-webkit-transform: translate3d(-2px, 0px, 0px);-moz-transform: translate3d(-2px, 0px, 0px);-o-transform: translate3d(-2px, 0px, 0px);margin: 10px 0%;box-sizing: border-box;\">\n<section style=\"display: inline-block;min-width: 10%;max-width: 100%;vertical-align: top;background-color: rgb(255, 202, 0);box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin: 5px 0% -5px;transform: translate3d(5px, 0px, 0px);-webkit-transform: translate3d(5px, 0px, 0px);-moz-transform: translate3d(5px, 0px, 0px);-o-transform: translate3d(5px, 0px, 0px);box-sizing: border-box;\">\n<section style=\"display: inline-block;min-width: 10%;max-width: 100%;vertical-align: top;border-style: solid;border-width: 8px 1px 1px;border-radius: 0px;border-color: rgb(62, 62, 62);background-color: rgb(255, 255, 255);padding-right: 8px;padding-left: 8px;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: left;padding-right: 8px;padding-left: 8px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u5173\u6ce8\u95ee\u9898<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u968f\u7740ICH\u6307\u5bfc\u539f\u5219\u5728\u56fd\u5185\u843d\u5730\u5b9e\u65bd\uff0c\u4e0e\u4e4b\u524d\u4e00\u822c\u5728\u4e34\u5e8a\u8bd5\u9a8c\u5f00\u5c55\u4e86I\u3001II\u6bb5\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u76f8\u6bd4\uff0c\u76ee\u524d\u8d8a\u6765\u8d8a\u591a\u7684\u54c1\u79cd\u5728\u672a\u8fdb\u884c\u6b63\u5f0f\u7684\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u7684\u60c5\u51b5\u4e0b\u7533\u8bf7\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\u3002\u4f46\u662f\uff0c\u57fa\u4e8e\u7533\u62a5\u8d44\u6599\u63d0\u4ea4\u60c5\u51b5\uff0c\u53d1\u73b0\u5b58\u5728\u4e00\u4e9b\u8ba4\u8bc6\u7684\u8bef\u533a\uff0c\u4f8b\u5982\u8ba4\u4e3a\u65e9\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e0d\u9700\u8981\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u7684\u652f\u6301\uff0c\u751a\u81f3\u6709\u4e9b\u7533\u62a5\u8d44\u6599\u76f4\u63a5\u5728\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u9879\u4e0b\u6807\u6ce8\u201c\u4e0d\u9002\u7528\u201d\uff0c\u800c\u672a\u63d0\u4f9b\u4efb\u4f55\u751f\u6b96\u6bd2\u6027\u98ce\u9669\u8bc4\u4f30\u3002\u5b9e\u9645\u4e0a\uff0c\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u9002\u5f53\u5ef6\u8fdf\u7684\u524d\u63d0\u6761\u4ef6\u662f\u5728\u5df2\u83b7\u5f97\u4fe1\u606f\u7684\u57fa\u7840\u4e0a\u52a0\u4e0a\u4e34\u5e8a\u8bd5\u9a8c\u671f\u95f4\u4e25\u683c\u7684\u63a7\u5236\u63aa\u65bd\uff0c\u80fd\u63a7\u5236\u4e34\u5e8a\u8bd5\u9a8c\u53d7\u8bd5\u8005\u7684\u751f\u6b96\u6bd2\u6027\u98ce\u9669\u3002\u4ee5\u4e0b\u9610\u8ff0\u51e0\u4e2a\u9700\u8981\u91cd\u70b9\u5173\u6ce8\u95ee\u9898\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 8%;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;width: 50%;box-sizing: border-box;\"><img class=\"raw-image\"     style=\"vertical-align: middle;width: 100%;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/2-1555469783.png\" alt=\"ICH M3\uff08R2\uff09\u5b9e\u65bd\u4e2d\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u9700\u8981\u5173\u6ce8\u7684\u95ee\u9898\" title=\"ICH M3\uff08R2\uff09\u5b9e\u65bd\u4e2d\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u9700\u8981\u5173\u6ce8\u7684\u95ee\u9898\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 92%;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 12px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u91cd\u590d\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c\u4e2d\u751f\u6b96\u7cfb\u7edf\u7ec4\u7ec7\u75c5\u7406\u5b66\u68c0\u67e5\u7684\u8981\u6c42<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">ICH&nbsp;M3(R2)\u63d0\u51fa\uff1a\u5728\u671f\u9650\u81f3\u5c112\u5468\u7684\u91cd\u590d\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c\uff08\u901a\u5e38\u4e3a\u556e\u9f7f\u7c7b\u52a8\u7269\uff09\u4e2d\u5bf9\u777e\u4e38\u548c\u5375\u5de2\u8fdb\u884c\u5168\u9762\u6807\u51c6\uff08thorough&nbsp;standard\uff09\u7684\u7ec4\u7ec7\u75c5\u7406\u5b66\u68c0\u67e5\uff0c\u7528\u4e8e\u5bf9\u96cc\u96c4\u751f\u80b2\u529b\u8fdb\u884c\u8bc4\u4f30\uff0c\u88ab\u8ba4\u4e3a\u4e0e\u68c0\u6d4b\u96cc\u96c4\u751f\u6b96\u5668\u5b98\u6bd2\u6027\u7684\u751f\u80b2\u529b\u8bd5\u9a8c\u540c\u6837\u7075\u654f\uff1b\u56e0\u4e3a\u91cd\u590d\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c\u8bc4\u4f30\u4e86\u836f\u7269\u5bf9\u96c4\u6027\u751f\u6b96\u5668\u5b98\u7684\u5f71\u54cd\uff0c\u5728\u96c4\u6027\u751f\u80b2\u529b\u8bd5\u9a8c\u5b8c\u6210\u524d\u7537\u6027\u53d7\u8bd5\u8005\u53ef\u4ee5\u5165\u9009\u2160\u3001\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff1b\u5728\u91cd\u590d\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c\u4e2d\u5bf9\u96cc\u6027\u751f\u6b96\u5668\u5b98\u8fdb\u884c\u4e86\u8bc4\u4ef7\u7684\u524d\u63d0\u4e0b\uff0c\u5728\u96cc\u6027\u751f\u80b2\u529b\u8bd5\u9a8c\u8fdb\u884c\u4e4b\u524d\uff0c\u591a\u6b21\u7ed9\u836f\u7684\u2160\u3001\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u53ef\u4ee5\u7eb3\u5165WOCBP\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5bf9\u4e8eM3(R2)\u4e2d\u63d0\u51fa\u7684\u751f\u6b96\u5668\u5b98\u7684\u68c0\u67e5\u8981\u6c42\uff0cICH&nbsp;S5(R2)<sup><span style=\"font-size:16px;vertical-align:super;\">&nbsp;[4]<\/span><\/sup>\u63d0\u51fa\uff1a\u826f\u597d\u7684\u96c4\u6027\u52a8\u7269\u751f\u6b96\u5668\u5b98\u75c5\u7406\u5b66\u548c\u7ec4\u7ec7\u75c5\u7406\u5b66\u68c0\u67e5\uff08\u5982\u901a\u8fc7Bouin\u2019s\u6db2\u56fa\u5b9a\u3001\u77f3\u8721\u5305\u57cb\u3001\u777e\u4e382-4\u03bcm\u6a2a\u5207\u7247\uff0c\u9644\u777e\u7eb5\u5207\u7247\uff0cPAS-\u82cf\u6728\u7d20\u67d3\u8272\uff09\u662f\u68c0\u67e5\u5bf9\u7cbe\u5b50\u53d1\u751f\u7684\u5f71\u54cd\u7684\u4e00\u79cd\u66f4\u4e3a\u654f\u611f\u548c\u5feb\u6377\u7684\u65b9\u6cd5\u3002\u4e3a\u4e86\u8fdb\u4e00\u6b65\u8bc1\u5b9e\u5176\u4ed6\u8bd5\u9a8c\u65b9\u6cd5\u6240\u89c2\u5bdf\u7684\u8bd5\u9a8c\u7ed3\u679c\u6216\u8fdb\u4e00\u6b65\u9610\u8ff0\u53d7\u8bd5\u7269\u7684\u4f5c\u7528\u7279\u70b9\uff0c\u7cbe\u5b50\u5206\u6790\u5b9e\u9a8c\uff08\u7cbe\u5b50\u8ba1\u6570\u3001\u7cbe\u5b50\u6d3b\u529b\u3001\u7cbe\u5b50\u5f62\u6001\u5b66\uff09\u53ef\u4f5c\u4e3a\u4e00\u79cd\u53ef\u9009\u65b9\u6cd5\u800c\u91c7\u7528\u3002\u5728\u8fdb\u884c\u7cbe\u5b50\u5206\u6790\u8bd5\u9a8c\u65f6\uff0c\u5982\u679c\u53d7\u68c0\u6837\u54c1\u53d6\u81ea\u4e8e\u8f93\u7cbe\u7ba1\u6216\u9644\u777e\uff0c\u8fd9\u79cd\u7cbe\u5b50\u5206\u6790\u8bd5\u9a8c\u7ed3\u679c\u5bf9\u751f\u80b2\u529b\u7684\u8bc4\u4ef7\u66f4\u5177\u6709\u76f8\u5173\u6027\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">ICH\u5bf9S5\u6b63\u5728\u4fee\u8ba2\u8fc7\u7a0b\u4e2d\uff0c\u4e8e2017\u5e74\u53d1\u5e03S5(R3)\u8349\u6848\u8fdb\u884c\u5f81\u6c42\u610f\u89c1\uff0c\u8be5\u8349\u6848\u63d0\u51fa\u7684\u76f8\u5173\u8981\u6c42\u4e3a\uff1a\u91cd\u590d\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c\u7684\u5168\u9762\u7684\u751f\u6b96\u5668\u5b98\u7ec4\u7ec7\u75c5\u7406\u5b66\u662f\u68c0\u6d4b\u5927\u591a\u6570\u96c4\u6027\u548c\u96cc\u6027\u751f\u80b2\u529b\u5f71\u54cd\u7684\u654f\u611f\u65b9\u6cd5\uff08\u52a8\u7269\u662f\u6027\u6210\u719f\u7684\uff09\uff1b\u5982\u679c\u4f7f\u7528\u91cd\u590d\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c\u6765\u8bc4\u4f30\u751f\u80b2\u529b\u5f71\u54cd\uff0c\u5e94\u5bf9\u96c4\u6027\u548c\u96cc\u6027\u52a8\u7269\u7684\u751f\u6b96\u5668\u5b98\u8fdb\u884c\u5168\u9762\uff08comprehesive\uff09\u7684\u7ec4\u7ec7\u75c5\u7406\u5b66\u68c0\u67e5\uff1b\u5f53\u57fa\u4e8e\u4f5c\u7528\u65b9\u5f0f\u6216\u5148\u524d\u8bd5\u9a8c\u6570\u636e\u5f15\u8d77\u62c5\u5fe7\u65f6\uff0c\u53ef\u5728\u91cd\u590d\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c\u4e2d\u5305\u62ec\u9644\u52a0\u7684\u68c0\u6d4b\uff0c\u4f8b\u5982\u7cbe\u5b50\u6536\u96c6\u548c\u5206\u6790\u3001\u76d1\u6d4b\u53d1\u60c5\u6216\u6708\u7ecf\u5468\u671f\uff1b\u5982\u679c\u5176\u4ed6\u8bd5\u9a8c\u7684\u6570\u636e\u8868\u660e\u96c4\u6027\u6216\u96cc\u6027\u751f\u6b96\u5668\u5b98\u7684\u91cd\u91cf\u6216\u7ec4\u7ec7\u75c5\u7406\u5b66\u6709\u5f71\u54cd\uff0c\u5219\u5e94\u8003\u8651\u66f4\u5168\u9762\u7684\u8bd5<span style=\"text-indent: 32px;line-height: 150%;\"><span style=\"font-family:\u5b8b\u4f53;\">\u9a8c<\/span><\/span><span style=\"text-indent: 32px;line-height: 150%;\"><span style=\"font-family:\u5b8b\u4f53;\">\u3002<\/span><\/span><sup style=\"text-indent: 32px;\"><span style=\"line-height:150%;font-size:16px;vertical-align:super;\">[5]&nbsp;<\/span><\/sup><\/p>\n<p style=\"text-indent:32px;line-height:150%;\"><sup><span style=\"line-height:150%;font-size:16px;vertical-align:super;\"><\/span><\/sup><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">&nbsp;<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u76ee\u524d\u5ba1\u8bc4\u4e2d\u5b58\u5728\u7684\u4e00\u4e2a\u5e38\u89c1\u95ee\u9898\u662f\uff0c\u7533\u8bf7\u4eba\u79f0\u6839\u636eICH&nbsp;M3(R2)\u8981\u6c42\uff0c\u56e0\u4e3a\u5df2\u8fdb\u884c\u4e86\u91cd\u590d\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c\uff0c\u8981\u6c42\u5728\u6ca1\u6709\u5b8c\u6210\u96c4\u6027\u548c\/\u6216\u96cc\u6027\u751f\u80b2\u529b\u8bd5\u9a8c\u7684\u60c5\u51b5\u4e0b\u8fdb\u884c\u2160\u3001\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4f46\u662f\u7533\u8bf7\u4eba\u5f80\u5f80\u5ffd\u7565\u4e86\u4e00\u4e2a\u91cd\u8981\u95ee\u9898\uff0c\u91cd\u590d\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c\u5bf9\u751f\u6b96\u5668\u5b98\u5f71\u54cd\u7684\u68c0\u67e5\u662f\u5426\u8fbe\u5230\u751f\u6b96\u6bd2\u6027\u8bc4\u4ef7\u7684\u8981\u6c42\u3002\u6839\u636e\u56fd\u5185\u7684\u7814\u7a76\u73b0\u72b6\uff0c\u91cd\u590d\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c\u4e2d\u5e38\u5e38\u672a\u5145\u5206\u5173\u6ce8\u751f\u6b96\u7cfb\u7edf\u6bd2\u6027\u8bc4\u4ef7\uff0c\u672a\u80fd\u5168\u9762\u68c0\u6d4b\u548c\u8bc4\u4f30\u3002\u7efc\u5408\u4ee5\u4e0aICH\u6240\u9610\u8ff0\u7684\u8981\u6c42\uff0c\u62df\u901a\u8fc7\u91cd\u590d\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c\u53cd\u6620\u7684\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u4fe1\u606f\uff0c\u5728\u8bbe\u8ba1\u91cd\u590d\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c\u65f6\u8981\u7279\u522b\u5173\u6ce8\u5bf9\u751f\u6b96\u7cfb\u7edf\u7684\u5f71\u54cd\uff0c\u8fdb\u884c\u4e13\u95e8\u7684\u8bbe\u8ba1\u3002\u5728\u91cd\u590d\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c\u4e2d\u662f\u5426\u53ef\u521d\u6b65\u8bc4\u4ef7\u751f\u80b2\u529b\u7684\u5173\u952e\u56e0\u7d20\u662f\uff1a\u91cd\u590d\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c\u4e2d\u7684\u751f\u6b96\u7cfb\u7edf\u7ec4\u7ec7\u75c5\u7406\u5b66\u68c0\u67e5\u7ed3\u679c\u7684\u5168\u9762\u6027\u3001\u53ef\u9760\u6027\u3002\u9700\u8981\u8fbe\u5230\u7684\u57fa\u672c\u8981\u6c42\uff1a\u2460\u52a8\u7269\u8981\u6027\u6210\u719f\uff0c\u6709\u8db3\u591f\u6570\u91cf\uff1b\u2461\u7ec4\u7ec7\u75c5\u7406\u5b66\u68c0\u67e5\u8981\u5168\u9762\uff0c\u96c4\u6027\uff1a\u777e\u4e38\u548c\u9644\u777e\uff08\u542b\u7cbe\u5b50\u53d1\u751f\u5468\u671f\uff09\u7684\u8be6\u7ec6\u7684\u5b9a\u6027\u955c\u68c0\uff0c\u7cbe\u5b50\u9636\u6bb5\uff08\u5206\u671f\uff09\u7684\u5b9a\u91cf\u5206\u6790\u53ef\u7528\u4e8e\u5bf9\u5df2\u786e\u5b9a\u7684\u5f71\u54cd\u7684\u8fdb\u4e00\u6b65\u8868\u5f81\u7814\u7a76\uff1b\u96cc\u6027\uff1a\u5375\u5de2\uff08\u5305\u62ec\u5375\u6ce1\u3001\u9ec4\u4f53\u3001\u57fa\u8d28\u3001\u95f4\u8d28\u3001\u8109\u7ba1\u7cfb\u7edf\uff09\u3001\u5b50\u5bab\u548c\u9634\u9053\u7684\u8be6\u7ec6\u7684\u5b9a\u6027\u955c\u68c0\u7b49\uff0c\u5e76\u7279\u522b\u5173\u6ce8\u5bf9\u539f\u59cb\u548c\u521d\u7ea7\u5375\u6ce1\u7684\u5b9a\u6027\u8bc4\u4f30\u3002\u2462\u6b64\u5916\uff0c\u76ee\u524d\u56fd\u5185\u7684\u7ec4\u7ec7\u75c5\u7406\u5b66\u68c0\u67e5\u6c34\u5e73\u53c2\u5dee\u4e0d\u9f50\uff0c\u7ec4\u7ec7\u75c5\u7406\u5b66\u7684\u68c0\u67e5\u8d28\u91cf\u8981\u7ecf\u5f97\u8d77\u540c\u884c\u8bc4\u8bae\uff08\u5fc5\u8981\u65f6\u8981\u6c42\u63d0\u4f9b\u75c5\u7406\u5207\u7247\u9080\u8bf7\u75c5\u7406\u5b66\u4e13\u5bb6\u590d\u9605\u67e5<span style=\"text-indent: 32px;line-height: 150%;\"><span style=\"font-family:\u5b8b\u4f53;\">\uff09\u3002<\/span><\/span><sup style=\"text-indent: 32px;\"><span style=\"line-height:150%;font-size:16px;vertical-align:super;\">[6]<\/span><\/sup><\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 8%;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;width: 50%;box-sizing: border-box;\"><img class=\"raw-image\"     style=\"vertical-align: middle;width: 100%;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/5-1555469783.png\" alt=\"ICH M3\uff08R2\uff09\u5b9e\u65bd\u4e2d\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u9700\u8981\u5173\u6ce8\u7684\u95ee\u9898\" title=\"ICH M3\uff08R2\uff09\u5b9e\u65bd\u4e2d\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u9700\u8981\u5173\u6ce8\u7684\u95ee\u9898\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 92%;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 12px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u521d\u6b65\u80da\u80ce-\u80ce\u4ed4\u53d1\u80b2\u6bd2\u6027\u8bd5\u9a8c\u7684\u8981\u6c42<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">ICH&nbsp;M3(R2)\u4e2d\u8981\u6c42\uff0c\u901a\u5e38\u60c5\u51b5\u4e0b\u83b7\u5f97\u4e24\u79cd\u52a8\u7269\u79cd\u5c5e\u4e2d\u7684\u521d\u6b65EFD\u8bd5\u9a8c\uff08preliminary&nbsp;EFD\uff0cpEFD\uff09\u7ed3\u679c\uff0c\u5e76\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u91c7\u53d6\u4e25\u683c\u907f\u5b55\u63aa\u65bd\u540e\uff0cWOCBP\u53ef\u5165\u7ec4\u5c0f\u89c4\u6a21\u3001\u77ed\u65f6\u95f4\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff08\u5c0f\u4e8e150\u4eba\u3001\u4e0d\u8d85\u8fc73\u4e2a\u6708\uff09\u3002\u5982\u679c\u4e34\u5e8a\u8bd5\u9a8c\u8d85\u8fc7\u4e0a\u8ff0\u89c4\u6a21\u548c\u65f6\u95f4\uff0c\u9700\u8981\u5b8c\u6210\u6b63\u5f0fEFD\u8bd5\u9a8c\u3002\u6839\u636e\u8be5\u8981\u6c42\uff0c\u5e76\u975e\u2161\u6bb5\u8bd5\u9a8c\u76f4\u63a5\u5ef6\u8fdf\u81f3\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u524d\uff0c\u5728\u51e0\u671f\u4e34\u5e8a\u8bd5\u9a8c\u524d\u5b8c\u6210\u9700\u8981\u6839\u636e\u4e34\u5e8a\u8bd5\u9a8c\u53d7\u8bd5\u8005\u89c4\u683c\u548c\u671f\u9650\u800c\u5b9a\uff0c\u800c\u4e14\u9700\u8981\u521d\u6b65EFD\u8bd5\u9a8c\u7ed3\u679c\u7684\u652f\u6301\u3002\u56e0\u6b64\uff0c\u9700\u8981\u5145\u5206\u8ba4\u8bc6\u521d\u6b65EFD\u8bd5\u9a8c\uff0c\u5e76\u5408\u7406\u5730\u53bb\u8bc4\u4ef7\u5176\u7ed3\u679c\u5bf9\u521d\u6b65\u751f\u6b96\u98ce\u9669\u8bc4\u4f30\u7684\u8d21\u732e\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">M3(R2)\u5bf9\u521d\u6b65\u7684\u80da\u80ce-\u80ce\u4ed4\u53d1\u80b2\u6bd2\u6027\u8bd5\u9a8c\u8981\u6c42\u4e3a\uff1a\u5e94\u5177\u6709\u8db3\u591f\u7684\u5242\u91cf\uff0c\u5305\u62ec\u5bf9\u80ce\u4ed4\u5b58\u6d3b\u7387\u3001\u4f53\u91cd\u3001\u5916\u89c2\u548c\u5185\u810f\u68c0\u67e5\u7684\u8bc4\u4ef7\uff0c\u6bcf\u7ec4\u81f3\u5c116\u53ea\u6bcd\u4f53\u52a8\u7269\uff0c\u6bcd\u4f53\u52a8\u7269\u5728\u6574\u4e2a\u5668\u5b98\u751f\u6210\u7ed9\u836f\u3002\u8be5\u521d\u6b65\u7684\u975e\u4e34\u5e8a\u8bd5\u9a8c\u5e94\u5728\u7b26\u5408\u9ad8\u8d28\u91cf\u7684\u79d1\u5b66\u6807\u51c6\u4e14\u968f\u65f6\u53ef\u83b7\u5f97\u6570\u636e\u91c7\u96c6\u8bb0\u5f55\u7684\u6761\u4ef6\u4e0b\u8fdb\u884c\uff0c\u6216\u5728GLP\u6761\u4ef6\u4e0b\u8fdb<span style=\"text-indent: 32px;line-height: 150%;\"><span style=\"font-family:\u5b8b\u4f53;\">\u884c<\/span><\/span><span style=\"text-indent: 32px;line-height: 150%;\"><span style=\"font-family:\u5b8b\u4f53;\">\u3002<\/span><\/span><sup style=\"text-indent: 32px;\"><span style=\"line-height:150%;font-size:16px;vertical-align:super;\">[3]<\/span><\/sup><\/p>\n<p style=\"text-indent:32px;line-height:150%;\"><sup><span style=\"line-height:150%;font-size:16px;vertical-align:super;\"><\/span><\/sup><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u56e0\u6b64\uff0c\u521d\u6b65EFD\uff08pEFD\uff09\u8bd5\u9a8c\u5e76\u975e\u7b80\u5355\u7684\u9884\u8bd5\u9a8c\uff0c\u5728\u8bbe\u8ba1\u4e0a\u4e0e\u6b63\u5f0f\u7684EFD\u8bd5\u9a8c\u76f8\u4f3c\uff0c\u9664\u6bcf\u7ec4\u52a8\u7269\u7565\u5c11\u3001\u5c11\u4e2a\u522b\u6307\u6807\u3001\u5728\u4fdd\u6301\u8bd5\u9a8c\u8d28\u91cf\u7684\u6761\u4ef6\u4e0b\u53ef\u4e0d\u4e25\u683c\u9075\u4eceGLP\u5916\u3002\u5728\u8bc4\u4ef7\u521d\u6b65\u8bd5\u9a8c\u65f6\uff0c\u56e0\u5176\u52a8\u7269\u6570\u6709\u9650\uff0c\u6240\u4ee5\u9762\u5bf9\u7ed3\u679c\u8981\u8c28\u614e\u8bc4\u4ef7\uff08\u5c24\u5176\u9634\u6027\u7ed3\u679c\uff09\uff0c\u5982\u6709\u5176\u4ed6\u76f8\u5173\u7684\u751f\u6b96\u6bd2\u6027\u4fe1\u606f\u8d44\u6599\uff08\u5982\u540c\u7c7b\u836f\u7269\uff09\u53ef\u53c2\u8003\u65f6\uff0c\u8981\u5c3d\u53ef\u80fd\u5730\u7efc\u5408\u5206\u6790\u3002<\/p>\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 8%;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;width: 50%;box-sizing: border-box;\"><img class=\"raw-image\"     style=\"vertical-align: middle;width: 100%;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/7-1555469783.png\" alt=\"ICH M3\uff08R2\uff09\u5b9e\u65bd\u4e2d\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u9700\u8981\u5173\u6ce8\u7684\u95ee\u9898\" title=\"ICH M3\uff08R2\uff09\u5b9e\u65bd\u4e2d\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u9700\u8981\u5173\u6ce8\u7684\u95ee\u9898\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 92%;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 12px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u751f\u80b2\u529b\u8bd5\u9a8c\u96c4\u6027\u52a8\u7269\u4ea4\u914d\u524d\u7ed9\u836f\u65f6\u95f4\u7684\u9009\u62e9<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u5bf9\u4e8e\u2160\u6bb5\u8bd5\u9a8c\u96c4\u6027\u52a8\u7269\u4ea4\u914d\u524d\u7ed9\u836f\u65f6\u95f4\uff0c\u56fd\u5185\u751f\u6b96\u6bd2\u6027\u6307\u5bfc\u539f<span style=\"font-family:\u5b8b\u4f53;\">\u5219<\/span><sup><span style=\"font-size:16px;vertical-align:super;\">[1<\/span><\/sup><sup><span style=\"font-family:\u5b8b\u4f53;font-size:16px;vertical-align:super;\">\u3001<\/span><\/sup><sup><span style=\"font-size:16px;vertical-align:super;\">2]<\/span><\/sup><span style=\"font-family:\u5b8b\u4f53;\">\u8981<\/span>\u6c42\uff0c\u751f\u80b2\u529b\u8bd5\u9a8c\u5c24\u5176\u662f\u51cf\u5c11\u96c4\u6027\u52a8\u7269\u4ea4\u914d\u524d\u7ed9\u836f\u671f\uff0c\u5e94\u6839\u636e\u524d\u671f\u8bd5\u9a8c\u6240\u79ef\u7d2f\u7684\u8d44\u6599\u4ee5\u53ca\u5bf9\u7cbe\u5b50\u53d1\u751f\u8fc7\u7a0b\u57fa\u7840\u7814\u7a76\u7684\u518d\u8bc4\u4ef7\u800c\u8bbe\u8ba1\u3002\u4e00\u822c\u60c5\u51b5\u4e0b\u4e3a4\uff5el0\u5468\u3002\u91cd\u590d\u7ed9\u836f\u8bd5\u9a8c\u53ef\u63d0\u4f9b\u53d7\u8bd5\u7269\u5bf9\u7cbe\u5b50\u53d1\u751f\u7684\u6f5c\u5728\u5f71\u54cd\u7684\u4fe1\u606f\u3002\u5982\u679c\u57281\u4e2a\u6708\u4ee5\u4e0a\u7684\u91cd\u590d\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c\u4e2d\u672a\u53d1\u73b0\u4efb\u4f55\u6bd2\u526f\u4f5c\u7528\uff0c\u5728\u4ea4\u914d\u524d\u96c4\u6027\u52a8\u7269\u4ea4\u914d\u524d\u7ed9\u836f\u65f6\u95f4\u53ef\u7f29\u77ed\u81f34\u5468\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">ICH&nbsp;S5(R2)\u6307\u5bfc\u539f<span style=\"font-family:\u5b8b\u4f53;\">\u5219<\/span><sup><span style=\"font-size:16px;vertical-align:super;\">[4]<\/span><\/sup>\u8ba4\u4e3a\uff1a\u5bf9\u4e8e\u7ed9\u836f\u65f6\u95f4\uff0c\u5c24\u5176\u662f\u8bc4\u4ef7\u53d7\u8bd5\u7269\u5bf9\u7cbe\u5b50\u751f\u6210\u5f71\u54cd\u65f6\uff0c\u5e94\u5229\u7528\u5df2\u6709\u7684\u6bd2\u6027\u7814\u7a76\u8d44\u6599\uff08\u5982\u7ec4\u7ec7\u75c5\u7406\u5b66\u68c0\u67e5\u3001\u751f\u6b96\u5668\u5b98\u91cd\u91cf\u3001\u5728\u4e00\u4e9b\u60c5\u51b5\u4e0b\u7684\u6fc0\u7d20\u68c0\u6d4b\u548c\u9057\u4f20\u6bd2\u6027\u6570\u636e\uff09\u3002\u5982\u679c\u5728\u81f3\u5c112\u5468\u7684\u91cd\u590d\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c\u4e2d\u672a\u53d1\u73b0\u4efb\u4f55\u5f71\u54cd\uff0c\u4ea4\u914d\u524d\u96c4\u6027\u52a8\u7269\u7ed9\u836f2\u5468\u4fbf\u53ef\u3002\u5e94\u8bf4\u660e\u9009\u62e9\u7ed9\u836f\u65f6\u95f4\u7684\u7406\u7531\u5e76\u63d0\u4f9b\u4f9d\u636e\u3002\u6b64\u5916\uff0c\u9488\u5bf9\u5176\u4f59\u8bd5\u9a8c\u8d44\u6599\u63d0\u793a\u53ef\u80fd\u6709\u62c5\u5fe7\u6216\u65e0\u8d44\u6599\u65f6\uff0cICH&nbsp;S5(R2)\u6307\u5bfc\u539f\u5219\u63d0\u51fa\uff1a\u5982\u679c\u5176\u4ed6\u7684\u7814\u7a76\u8d44\u6599\u663e\u793a\u5bf9\u96c4\u6027\u6216\u96cc\u6027\u751f\u6b96\u5668\u5b98\u91cd\u91cf\u6216\u7ec4\u7ec7\u5b66\u6709\u5f71\u54cd\uff0c\u6216\u5982\u679c\u5bf9\u8bd5\u9a8c\u68c0\u67e5\u7ed3\u679c\u7684\u8d28\u91cf\u6709\u7591\u95ee\uff0c\u6216\u5982\u679c\u5b8c\u5168\u6ca1\u6709\u5176\u4ed6\u7684\u7814\u7a76\u8d44\u6599\uff0c\u5e94\u8003\u8651\u8fdb\u884c\u66f4\u5168\u9762\u7814\u7a76\u7684\u5fc5\u8981\u6027\u3002<sup><span style=\"font-size:16px;vertical-align:super;\">[4]<\/span><\/sup><\/p>\n<p><sup><span style=\"font-size:16px;vertical-align:super;\"><\/span><\/sup><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u9700\u8981\u5173\u6ce8\u7684\u662f\u5927\u9f20\u7cbe\u5b50\u53d1\u751f(\u5305\u62ec\u7cbe\u5b50\u6210\u719f\uff09\u6574\u4e2a\u8fc7\u7a0b\u9700\u898163\u5929\uff08\u53739\u5468\uff09\uff0c\u96c4\u6027\u4ea4\u914d\u524d\u7ed9\u836f\u65f6\u95f4\u7f29\u77ed\u4e3a2\u5468\u5e76\u4e0d\u80fd\u8986\u76d6\u6574\u4e2a\u751f\u7cbe\u5468\u671f\u3002\u800c\u4e14\uff0c\u96c4\u6027\u751f\u80b2\u529b\u8bd5\u9a8c\u53ef\u8bc4\u4ef7\u53d7\u8bd5\u7269\u5bf9\u96c4\u6027\u751f\u80b2\u529b\u7684\u529f\u80fd\u6027\u5f71\u54cd\uff0c\u8fd9\u79cd\u529f\u80fd\u6027\u5f71\u54cd\u65e0\u6cd5\u5728\u91cd\u590d\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c\u4e2d\u7528\u7ec4\u7ec7\u75c5\u7406\u5b66\u7684\u65b9\u6cd5\u8fdb\u884c\u8bc4\u4ef7\u3002\u56e0\u6b64\uff0c\u6309\u7167ICH\u6307\u5bfc\u539f\u5219\u8981\u6c42\u6267\u884c\uff08\u96c4\u6027\u52a8\u7269\u4ea4\u914d\u524d\u7ed9\u836f2\u5468\uff09\u65f6\u8981\u5173\u6ce8\u5176\u524d\u63d0\u6761\u4ef6\uff0c\u4e00\u662f\u8981\u57fa\u4e8e\u5df2\u6709\u6bd2\u6027\u8bd5\u9a8c\u4e2d\u5bf9\u96c4\u6027\u751f\u80b2\u529b\u5f71\u54cd\u7684\u89c2\u5bdf\u662f\u5426\u8db3\u591f\uff0c\u4e8c\u662f\u91cd\u590d\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c\u4e2d\u672a\u53d1\u73b0\u5bf9\u96c4\u6027\u751f\u6b96\u6bd2\u6027\u76f8\u5173\u6307\u6807\u7684\u4efb\u4f55\u5f71\u54cd\uff0c\u800c\u8fd9\u4e24\u70b9\u5f80\u5f80\u662f\u73b0\u6709\u7533\u62a5\u8d44\u6599\u4e2d\u5173\u6ce8\u4e0d\u591f\u6216\u672a\u5173\u6ce8\u7684\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">\u7efc\u5408\u8003\u8651\uff0c\u5bf9\u4e8e\u96c4\u6027\u52a8\u7269\u4ea4\u914d\u524d\u7ed9\u836f\u65f6\u95f4\u7684\u9009\u62e9\uff0c\u5e94\u5177\u4f53\u95ee\u9898\u5177\u4f53\u5206\u6790\uff0c\u517c\u987e\u79d1\u5b66\u6027\u3001\u5408\u7406\u6027\u3001\u98ce\u9669\u6548\u76ca\u8bc4\u4f30\uff0c\u5728\u89c4\u8303\u3001\u4ed4\u7ec6\u7684\u91cd\u590d\u7ed9\u836f\u6bd2\u6027\u8bd5\u9a8c\uff08\u5c24\u5176\u96c4\u6027\u751f\u6b96\u5668\u5b98\u7ec4\u7ec7\u5b66\u68c0\u67e5\uff09\u672a\u53d1\u73b0\u660e\u663e\u6bd2\u6027\u53cd\u5e94\u7ed3\u679c\u7684\u652f\u6301\u4e0b\u53ef\u9002\u5f53\u7f29\u77ed\u4ea4\u914d\u524d\u7ed9\u836f\u65f6\u95f4\u3002\u5bf9\u4e8e\u540c\u7c7b\u54c1\u79cd\u63d0\u793a\u6709\u6f5c\u5728\u751f\u6b96\u6bd2\u6027\u98ce\u9669\u7684\u6216\u6bd2\u6027\u4fe1\u606f\u8f83\u5c11\u7684\u521b\u65b0\u836f\uff0c\u5efa\u8bae\u91c7\u7528\u8f83\u957f\u7684\u7ed9\u836f\u65f6\u95f4\uff0c\u5e76\u914d\u5408\u4ed4\u7ec6\u7684\u7cbe\u5b50\u5206\u6790\u548c\u751f\u6b96\u7cfb\u7edf\u75c5\u7406\u7ec4\u7ec7\u5b66\u68c0\u67e5<span style=\"text-indent: 28px;line-height: 150%;\"><span style=\"font-family:\u5b8b\u4f53;\">\u3002<\/span><\/span><sup style=\"text-indent: 28px;\"><span style=\"font-family:\u5b8b\u4f53;line-height:150%;font-size:16px;vertical-align:super;\">[7]<\/span><\/sup><\/p>\n<p style=\"text-indent:28px;line-height:150%;\"><sup><span style=\"font-family:\u5b8b\u4f53;line-height:150%;font-size:16px;vertical-align:super;\"><\/span><\/sup><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 8%;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin-top: 10px;margin-bottom: 10px;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;width: 50%;box-sizing: border-box;\"><img class=\"raw-image\"     style=\"vertical-align: middle;width: 100%;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/9-1555469783.png\" alt=\"ICH M3\uff08R2\uff09\u5b9e\u65bd\u4e2d\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u9700\u8981\u5173\u6ce8\u7684\u95ee\u9898\" title=\"ICH M3\uff08R2\uff09\u5b9e\u65bd\u4e2d\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u9700\u8981\u5173\u6ce8\u7684\u95ee\u9898\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 92%;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 12px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u7efc\u5408\u8bc4\u4ef7\u53ca\u4e34\u5e8a\u8bd5\u9a8c\u98ce\u9669\u63d0\u793a<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">\u6240\u6709\u7684\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u6700\u7ec8\u90fd\u662f\u4e3a\u4e86\u4eba\u4f53\u7684\u751f\u6b96\/\u53d1\u80b2\u98ce\u9669\u8bc4\u4f30\uff0c\u6700\u7ec8\u7684\u751f\u6b96\/\u53d1\u80b2\u98ce\u9669\u8bc4\u4f30\u7ed3\u8bba\u5bf9\u4e8e\u4e34\u5e8a\u8bd5\u9a8c\u6216\u4e34\u5e8a\u5e94\u7528\u4e2d\u4eba\u4f53\u751f\u6b96\u53d1\u80b2\u98ce\u9669\u7684\u9884\u9632\u7ba1\u63a7\u6709\u7740\u5f88\u9ad8\u7684\u6307\u5bfc\u4ef7\u503c\u3002\u8fd9\u9700\u8981\u5728\u8bc4\u4f30\u751f\u6b96\u53d1\u80b2\u98ce\u9669\u65f6\uff0c\u8981\u7efc\u5408\u6240\u6709\u53ef\u7528\u7684\u6570\u636e\uff08\u5305\u62ec\u52a8\u7269\u751f\u6b96\u6bd2\u6027\u6570\u636e\u3001\u5176\u4ed6\u6bd2\u6027\u8bd5\u9a8c\u6570\u636e\u3001\u53ef\u80fd\u6709\u7684\u4e34\u5e8a\u5b89\u5168\u6027\u53ca\u836f\u4ee3\u6570\u636e\u3001\u53d7\u8bd5\u7269\u4f5c\u7528\u673a\u5236\u9776\u6807\u7b49\u80cc\u666f\u4fe1\u606f\u3001\u540c\u7c7b\/\u76f8\u5173\u836f\u7269\u5ba1\u8bc4\u7ecf\u9a8c\u6216\u6bd2\u6027\u63d0\u9192\u7b49\uff09\uff0c\u4ee5\u53ca\u4e34\u5e8a\u6cbb\u7597\u7684\u6548\u76ca\u8003\u8651\uff0c\u7ed9\u51fa\u5ba2\u89c2\u3001\u8c28\u614e\u3001\u57fa\u4e8e\u66b4\u9732\u7684\u4eba\u4f53\u98ce\u9669\u8bc4\u4f30\u7ed3\u8bba\uff0c\u5e76\u57fa\u4e8e\u751f\u6b96\u6bd2\u6027\u98ce\u9669\u8bc4\u4f30\uff0c\u63d0\u793a\u4e34\u5e8a\u8bd5\u9a8c\u5e94\u91c7\u53d6\u7684\u751f\u6b96\u6bd2\u6027\u98ce\u9669\u63a7\u5236\u63aa\u65bd\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">ICH&nbsp;M3\uff08R2\uff09\u5bf9\u907f\u5b55\u63aa\u65bd\u8fdb\u884c\u4e86\u9610\u8ff0\uff08\u89c1\u4e0a\u6587\uff09\uff0c\u5305\u62ec\u901a\u8fc7\u53d7\u8bd5\u8005\u7eb3\u5165\u9650\u5236\u3001\u9ad8\u6548\u7684\u907f\u5b55\u65b9\u6cd5\u3001\u8bd5\u9a8c\u671f\u95f4\u7684\u598a\u5a20\u68c0\u6d4b\u548c\u53d7\u8bd5\u8005\u6559\u80b2\u3001\u77e5\u60c5\u540c\u610f\u4e66\u4e2d\u7684\u4fe1\u606f\u53cd\u6620\u7b49\uff0c\u4f46\u662f\u76ee\u524d\u56fd\u5185\u4e34\u5e8a\u8bd5\u9a8c\u7684\u907f\u5b55\u63aa\u65bd\u5927\u591a\u672a\u8fbe\u5230\u6b64\u8981\u6c42\u3002\u800c\u4e14\uff0c\u4ece\u4e34\u5e8a\u8bd5\u9a8c\u5b9e\u9645\u60c5\u51b5\u770b\uff0c\u786e\u5b9e\u5b58\u5728\u98ce\u9669\u63a7\u5236\u63aa\u65bd\u4e0d\u8db3\u800c\u5bfc\u81f4\u8bd5\u9a8c\u8fc7\u7a0b\u4e2d\u598a\u5a20\u6216\u6d41\u4ea7\u7684\u4e8b\u4ef6\u53d1\u751f\u3002\u56e0\u6b64\uff0c\u65e0\u8bba\u662f\u5bf9\u4e8e\u5728\u65e0\u6b63\u5f0f\u7684\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8fd8\u662f\u5df2\u6709\u8bd5\u9a8c\u4fe1\u606f\u63d0\u793a\u5177\u6709\u751f\u6b96\u6bd2\u6027\u98ce\u9669\u65f6\uff0c\u9700\u6309\u7167ICH&nbsp;M3\uff08R2\uff09\u8981\u6c42\u91c7\u7528\u4e25\u683c\u7684\u751f\u6b96\u6bd2\u6027\u98ce\u9669\u63a7\u5236\uff0c\u4ee5\u4fdd\u62a4\u597d\u53d7\u8bd5\u8005\u5b89\u5168\u6027\u3002<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br  \/><\/p>\n<section style=\"box-sizing: border-box;font-size: 16px;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin: 10px 0%;box-sizing: border-box;\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;border-style: solid;border-width: 1px;border-radius: 0px;border-color: rgb(225, 193, 146);box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 5px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"color: rgb(117, 117, 117);padding-right: 10px;padding-left: 10px;font-size: 15px;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\">\u53c2\u8003\u6587\u732e<\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 8px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"background-color: rgb(225, 193, 146);height: 1px;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;text-align: left;\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;padding: 10px;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"font-size: 14px;color: rgb(117, 117, 117);line-height: 1.8;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\">[1]\u56fd\u5bb6\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40.\u836f\u7269\u751f\u6b96\u6bd2\u6027\u7814\u7a76\u6280\u672f\u6307\u5bfc\u539f\u5219[S] .2006.<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">[2]\u738b\u5e86\u5229,&nbsp;\u9ec4\u82b3\u534e,&nbsp;\u5f6d\u5065,\u7b49.\u836f\u7269\u751f\u6b96\u6bd2\u6027\u7814\u7a76\u7684\u8003\u8651\u8981\u70b9[J].\u4e2d\u56fd\u65b0\u836f\u6742\u5fd7,&nbsp;2007,&nbsp;16(10):&nbsp;737-739.<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">[3]&nbsp;ICH.&nbsp;M3&nbsp;(R2)&nbsp;Guidance&nbsp;on&nbsp;nonclinical&nbsp;safety&nbsp;studies&nbsp;for&nbsp;the&nbsp;conduct&nbsp;of&nbsp;human&nbsp;clinical&nbsp;trials&nbsp;and&nbsp;marketing&nbsp;authorization&nbsp;for&nbsp;pharmaceuticals[EB\/OL].&nbsp;(2009-06-11).&nbsp;http:\/\/www.ich.org\uff0e&nbsp;<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">[4]ICH\uff0eS5(R2)\uff1aDetection&nbsp;of&nbsp;toxicity&nbsp;to&nbsp;reproduction&nbsp;for&nbsp;medicinal&nbsp;products&nbsp;&amp;&nbsp;toxicity&nbsp;to&nbsp;male&nbsp;fertility&nbsp;[EB\/OL].&nbsp;\uff082005-11\uff09\uff0ehttp:\/\/www.ich.org\uff0e&nbsp;<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">[5]ICH\uff0eS5(R3)\uff08draft\uff09\uff1aDetection&nbsp;of&nbsp;toxicity&nbsp;to&nbsp;reproduction&nbsp;for&nbsp;human&nbsp;pharmaceuticals[EB\/OL].&nbsp;\uff082017-07-05\uff09http:\/\/www.ich.org\uff0e&nbsp;<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">[6]\u5f20\u7acb\u5c06\uff0c\u9ec4\u82b3\u534e\u3002\u6d45\u6790ICH&nbsp;S5(R3)\u836f\u7269\u751f\u6b96\u6bd2\u6027\u7814\u7a76\u6307\u5bfc\u539f\u5219\u8349\u6848\u7684\u65b0\u6280\u672f\u8981\u6c42\u53ca\u5176\u6311\u6218\u3002\u4e2d\u56fd\u65b0\u836f\u6742\u5fd7,2018,27\uff0818\uff09:&nbsp;2088-2097<\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\">[7]\u5f20\u7acb\u5c06\uff0c\u9ec4\u82b3\u534e\u3001\u738b\u5e86\u5229\u7b49\uff0c\u836f\u7269\u96c4\u6027\u751f\u6b96\u6bd2\u6027\u8bc4\u4ef7\u8003\u8651\u8981\u70b9\u53caFDA\u76f8\u5173\u6307\u5bfc\u539f\u5219\u4ecb\u7ecd\uff0c\u4e2d\u56fd\u65b0\u836f\u6742\u5fd7,2016,&nbsp;25(24)&nbsp;:&nbsp;2766-2772<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-right: 0%;margin-bottom: 8px;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"background-color: rgb(225, 193, 146);height: 1px;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;box-sizing: border-box;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: right;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u4f9b\u7a3f\/\u836f\u7406\u6bd2\u7406\u5b66\u90e8<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><br style=\"box-sizing: border-box;\"  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 0.5em;margin-bottom: 0.5em;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;\"><img class=\"raw-image\"     style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/6-1555469783.gif\" alt=\"ICH M3\uff08R2\uff09\u5b9e\u65bd\u4e2d\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u9700\u8981\u5173\u6ce8\u7684\u95ee\u9898\" title=\"ICH M3\uff08R2\uff09\u5b9e\u65bd\u4e2d\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u9700\u8981\u5173\u6ce8\u7684\u95ee\u9898\"  \/><\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<section  label=\"Powered by 135editor.com\" style=\"font-size:16px;\">\n<section  label=\"Powered by 135editor.com\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;\"  class=\"_135editor\">\n<section style=\"box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;border-width: 0px;border-style: none;border-color: initial;\"  class=\"_135editor\">\n<section style=\"text-align: center;margin: 15px 0%;box-sizing: border-box;\">\n<section style=\"display: inline-block;width: 98%;vertical-align: top;border-style: solid;border-width: 1px;border-radius: 0px;border-color: #bdbdbd;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"display: inline-block;vertical-align: top;width: 80%;padding-right: 10px;padding-left: 10px;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 8px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"text-align: left;color: #e78730;box-sizing: border-box;\">\n<p style=\"box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">\u5f80\u671f\u56de\u987e<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"margin-top: 5px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"background-color: #e78730;height: 2px;box-sizing: border-box;\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"display: inline-block;vertical-align: top;width: 20%;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"text-align: right;margin-top: -11px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;transform: translate3d(1px, 0px, 0px);-webkit-transform: translate3d(1px, 0px, 0px);-moz-transform: translate3d(1px, 0px, 0px);-ms-transform: translate3d(1px, 0px, 0px);-o-transform: translate3d(1px, 0px, 0px);\">\n<section style=\"display: inline-block;width: 40px;height: 50px;vertical-align: top;overflow: hidden;background-color: #ffffff;padding-top: 10px;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"text-align: center;margin-right: 0%;margin-left: 0%;box-sizing: border-box;\">\n<section style=\"max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;\"><img class=\"raw-image\"     style=\"vertical-align: middle;box-sizing: border-box;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/0-1555469783.png\" alt=\"ICH M3\uff08R2\uff09\u5b9e\u65bd\u4e2d\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u9700\u8981\u5173\u6ce8\u7684\u95ee\u9898\" title=\"ICH M3\uff08R2\uff09\u5b9e\u65bd\u4e2d\u751f\u6b96\u6bd2\u6027\u8bd5\u9a8c\u9700\u8981\u5173\u6ce8\u7684\u95ee\u9898\"  \/><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"display: inline-block;width: 100%;vertical-align: top;padding: 20px 10px;box-sizing: border-box;\">\n<section style=\"box-sizing: border-box;\" >\n<section style=\"box-sizing: border-box;\">\n<section style=\"text-align: justify;font-size: 14px;line-height: 1.8;color: #a0a0a0;box-sizing: border-box;\">\n<p style=\"white-space: normal;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">[1]<\/strong><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzUzNjA1ODg4NQ==&amp;mid=2247485840&amp;idx=1&amp;sn=08affaf5e0960c516824e1b48fb2dd14&amp;scene=21#wechat_redirect\" target=\"_blank\" style=\"text-decoration: underline;letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5fae\u8f6f\u96c5\u9ed1, &quot;Microsoft YaHei&quot;color: rgb(2, 30, 170);\" ><span style=\"letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5fae\u8f6f\u96c5\u9ed1, &quot;Microsoft YaHei&quot;color: rgb(2, 30, 170);\">\u91cd\u7ec4\u4eba\u51dd\u8840\u56e0\u5b50\u2167\u548c\u2168\u4e34\u5e8a\u8bd5\u9a8c\u5171\u6027\u95ee\u9898\u7684\u63a2\u8ba8<\/span><\/a><span style=\"color: rgb(51, 51, 51);letter-spacing: 0.544px;widows: 1;caret-color: red;font-family: \u5fae\u8f6f\u96c5\u9ed1, &quot;Microsoft YaHei&quot;\"><\/span><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><strong style=\"letter-spacing: 0px;box-sizing: border-box;\">&nbsp;&nbsp;<\/strong><br style=\"box-sizing: border-box;\"  \/><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">[2]<\/strong><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzUzNjA1ODg4NQ==&amp;mid=2247485587&amp;idx=4&amp;sn=80f059414ab7305e62393e55b3f5a046&amp;scene=21#wechat_redirect\" target=\"_blank\" ><span style=\"letter-spacing: 0px;box-sizing: border-box;\">\u72c2\u72ac\u75c5\u75c5\u6bd2\u5355\u514b\u9686\u6297\u4f53\u4e34\u5e8a\u8bd5\u9a8c\u8bbe\u8ba1\u548c\u8bc4\u4ef7\u8981\u70b9<\/span><\/a><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><strong style=\"letter-spacing: 0px;box-sizing: border-box;\">&nbsp; &nbsp;&nbsp;<\/strong><\/p>\n<p style=\"white-space: normal;box-sizing: border-box;\"><strong style=\"box-sizing: border-box;\">[3]<\/strong><span style=\"letter-spacing: 0px;box-sizing: border-box;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzUzNjA1ODg4NQ==&amp;mid=2247485467&amp;idx=2&amp;sn=9741f75d19078163fec49a5da8302458&amp;scene=21#wechat_redirect\" target=\"_blank\" >\u5316\u5b66\u836f\u54c1\u4eff\u5236\u836f\u8c41\u514d\u4eba\u4f53\u751f\u7269\u7b49\u6548\u6027\u7814\u7a76\u7684\u4e00\u822c\u8003\u8651<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"box-sizing: border-box;\"><br  \/><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"text-align: center;\">\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u836f\u7269\u5f00\u53d1\u662f\u4e00\u4e2a\u9010\u6b65\u9012\u8fdb\u7684\u8fc7\u7a0b\uff0c\u5bf9\u52a8\u7269\u548c\u4eba\u4f53\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u7684\u7814\u7a76\u8bc4\u4ef7\u968f\u7740\u5f00\u53d1\u8fdb\u7a0b\u4e0d\u65ad\u5f80\u524d\u63a8\u8fdb\u3002\u751f\u6b96\u6bd2\u6027\u662f\u836f\u7269\u975e\u4e34 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":82732,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/82731"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=82731"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/82731\/revisions"}],"predecessor-version":[{"id":82744,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/82731\/revisions\/82744"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/82732"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=82731"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=82731"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=82731"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}