{"id":82981,"date":"2019-04-15T00:00:50","date_gmt":"2019-04-17T02:59:00","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/82981\/"},"modified":"2019-04-17T10:59:01","modified_gmt":"2019-04-17T02:59:01","slug":"c700b6f4c3","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/82981\/","title":{"rendered":"2019\u5e743\u6708\u836f\u7269\u5feb\u8baf\u2014\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001"},"content":{"rendered":"
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\u4e2d\u6587\u7ffb\u8bd1\uff1a\u963f\u6817\u535a\u58eb<\/span><\/p>\n

Daily Drug News \u5df2\u6b63\u5f0f\u66f4\u540d\u4e3aBioWorld Science<\/span><\/p>\n


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      2019\u5e743\u670829\u65e5\uff0cFT-113\u5728\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\u663e\u793a\u6297\u80bf\u7624\u6d3b\u6027<\/span><\/span><\/p>\n<\/li>\n

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      <\/span>2019\u5e743\u670822\u65e5\uff0c\u9965\u997f\u7684\u764c\u7ec6\u80de\u5982\u4f55\u751f\u957f\uff1f<\/span><\/p>\n<\/li>\n

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      <\/span>2019\u5e743\u670813\u65e5\uff0c\u827e\u4f2f\u7ef4\u516c\u53f8\u53d1\u73b0\u65b0\u7684Mcl-1\u6291\u5236\u5242<\/span><\/p>\n<\/li>\n<\/ul>\n

      \u80bf\u7624\u514d\u75ab\u7597\u6cd5<\/strong><\/span><\/p>\n

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        2019\u5e743\u670825\u65e5\uff0c\u6eb6\u7624\u547c\u80a0\u5b64\u75c5\u6bd2\u5bf9\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u6709\u6cbb\u7597\u4f5c\u7528<\/span><\/p>\n<\/li>\n

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        2019\u5e743\u67081\u65e5\uff0c\u5b89\u8fdb\u53d1\u8868AMG-160\u79ef\u6781\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u6570\u636e<\/span><\/p>\n<\/li>\n<\/ul>\n

        \u5fc3\u8840\u7ba1\u75be\u75c5<\/strong><\/span><\/p>\n

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          <\/span>2019\u5e743\u670826\u65e5\uff0cREDUCE-IT\u7814\u7a76\u8bc1\u5b9eVascepa\u53ef\u51cf\u5c11\u7f3a\u8840\u4e8b\u4ef6<\/span><\/p>\n<\/li>\n<\/ul>\n

          \u836f\u7269\u8bbe\u8ba1\u53ca\u836f\u7269\u91ca\u653e\u6280\u672f<\/strong><\/span><\/p>\n

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            2019\u5e743\u670812\u65e5\uff0c\u542c\u529b\u635f\u4f24\u7684\u57fa\u56e0\u7597\u6cd5\u5728\u6210\u5e74\u8001\u9f20\u8eab\u4e0a\u6709\u6548<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

            \u5185\u5206\u6ccc\u7cfb\u7edf\u75be\u75c5<\/strong><\/span><\/strong><\/span><\/p>\n

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              2019\u5e743\u67086\u65e5\uff0c\u6768\u68ee\u516c\u53f8\u53d1\u73b0\u65b0\u7684\u524d\u5217\u817a\u7d20EP3\u53d7\u4f53\u62ee\u6297\u5242<\/span><\/p>\n<\/li>\n<\/ul>\n

              \u773c\u79d1\u75be\u75c5<\/strong><\/span><\/p>\n

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                2019\u5e743\u670815\u65e5\uff0cAhR\u88ab\u8bc1\u5b9e\u53ef\u6210\u4e3a\u6cbb\u7597\u8001\u5e74\u6027\u9ec4\u6591\u53d8\u6027\u7684\u9776\u6807<\/span><\/p>\n<\/li>\n<\/ul>\n

                \u4ee3\u8c22\u7c7b\u75be\u75c5<\/strong><\/span><\/strong><\/p>\n

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                  <\/span>2019\u5e743\u67086\u65e5\uff0c\u4e3a\u5de8\u566c\u7ec6\u80de\u63d0\u4f9b\u8102\u80aa\u7684\u65b0\u9014\u5f84<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                  \u808c\u8089\u9aa8\u9abc\u548c\u7ed3\u7f14\u7ec4\u7ec7<\/strong>\u75be\u75c5<\/strong><\/span><\/p>\n

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                    2019\u5e743\u67084\u65e5\uff0c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u516c\u53f8\u53d1\u73b0\u6eb6\u8840\u78f7\u8102S1P1\u53d7\u4f53\u6fc0\u52a8\u5242<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                    \u80c3\u80a0\u9053\u75be<\/strong>\u75c5<\/strong><\/span><\/p>\n

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                      2019\u5e743\u670814\u65e5\uff0c\u65b0\u7684\u751f\u7269\u6807\u5fd7\u7269\u53ef\u7528\u4e8e\u9274\u5b9a\u708e\u75c7\u6027\u80a0\u75c5\u7684\u4e25\u91cd\u7a0b\u5ea6<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

                      \u795e\u7ecf\u7cfb\u7edf\u75be\u75c5<\/strong><\/span>
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                        <\/span>2019\u5e743\u67081\u65e5\uff0c\u6b66\u7530\u53d1\u73b0\u65b0\u7ed3\u6784\u7684\u9009\u62e9\u6027Nav1.1\u79bb\u5b50\u901a\u9053\u6fc0\u6d3b\u5242<\/span><\/span><\/span><\/span><\/p>\n


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                        \u751f\u7269\u6807\u5fd7\u7269<\/span><\/strong><\/span><\/span><\/strong><\/p>\n

                        2019\u5e743\u670827\u65e5\uff0c\u5b55\u916e\u53ef\u7528\u6765\u9884\u6d4b\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u7684\u9884\u540e<\/span><\/p>\n

                        \u80be\u4e0a\u817a\u76ae\u8d28\u764c\uff08ACC\uff09\u662f\u4e00\u79cd\u9884\u540e\u8f83\u5dee\u7684\u81f4\u547d\u6027\u5185\u5206\u6ccc\u7cfb\u7edf\u6076\u6027\u80bf\u7624\uff0c\u7edd\u5927\u90e8\u5206\u75c5\u4f8b\uff0880-90%\uff09\u5b58\u5728\u80f0\u5c9b\u7d20\u6837\u751f\u957f\u56e0\u5b50I\uff08IGF-I\uff09\u53d7\u4f53\u7684\u4e0a\u8c03\u548cIGF-II\u7684\u8fc7\u8868\u8fbe\u3002\u672c\u5468\uff0c\u5728ENDO\u4f1a\u8bae\u4e0a\u53d1\u8868\u7684\u4e00\u9879\u7814\u7a76\uff0c\u5c55\u793a\u4e86\u7c7b\u56fa\u9187\u53d7\u4f53\u5728ACC\u4e2d\u7684\u8868\u8fbe\u53ca\u5176\u5bf9\u9884\u540e\u7684\u5f71\u54cd\u3002\u8be5\u7814\u7a76\u5bf916\u4f8bACC\u548c22\u4f8b\u826f\u6027\u80be\u4e0a\u817a\u76ae\u8d28\u817a\u7624\uff08ACA\uff09\u7684\u7ec4\u7ec7\u8fdb\u884c\u4e86\u5206\u6790\uff0c\u91c7\u7528\u514d\u75ab\u7ec4\u5316\u7684\u65b9\u6cd5\u68c0\u6d4b\u4e86\u96cc\u6fc0\u7d20\uff08ER\uff09\u3001\u96c4\u6fc0\u7d20\uff08AR\uff09\u548c\u5b55\u916e\u53d7\u4f53\uff08PR\uff09\u7684\u8868\u8fbe\u3002\u7ed3\u679c\u8868\u660e\uff0cER\u548cAR\u5728ACC\u4e2d\u7684\u8868\u8fbe\u660e\u663e\u9ad8\u4e8eACA\uff08P\u503c\u5206\u522b\u4e3a0.014\u548c0.005\uff09\uff0c\u800cPR\u5728ACC\u548cACA\u4e2d\u7684\u8868\u8fbe\u76f8\u4f3c\uff08P = 0.38\uff09\u3002\u6b64\u5916\uff0cACA\u60a3\u8005\u5916\u5468\u80be\u4e0a\u817a\u7ec4\u7ec7\u8868\u8fbe\u7684ER\u3001AR\u3001PR\u5747\u9ad8\u4e8eACC\u60a3\u8005\uff08P\u503c\u5747< 0.005\uff09\u3002\u4e09\u79cd\u6807\u5fd7\u7269\u9634\u6027\u7684ACC\u60a3\u8005\u80bf\u7624\u4f53\u79ef\u8f83\u5927\uff0cPR\u7684\u5dee\u5f02\u66f4\u4e3a\u663e\u8457\uff08P = 0.015\uff09\uff0cPR\u9633\u6027\u7684ACC\u60a3\u8005\u7684\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u77ed\u4e8ePR\u9634\u6027\u7684ACC\u60a3\u8005\uff0815\u4e2a\u6708vs. 57.5\u4e2a\u6708\uff0cP = 0.071\uff09\uff0c\u8fd9\u662f\u7531\u4e8eKi-67\u8868\u8fbe\u589e\u9ad8\u6240\u81f4\u3002\u4e0a\u8ff0\u7ed3\u8bba\u63d0\u793aPR\u53ef\u4f5c\u4e3aACC\u60a3\u8005\u9884\u540e\u4e0d\u826f\u7684\u4e00\u79cd\u751f\u7269\u6807\u5fd7\u7269\u3002\uff08Oguz, S. et al. 101st Annu Meet Endo Soc (ENDO) (March 23-26, New Orleans) 2019, Abst SUN-352\uff09\u3002<\/span><\/p>\n


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                        \u80bf\u7624<\/span><\/strong><\/span><\/span><\/strong><\/p>\n

                        2019\u5e743\u670829\u65e5\uff0cFT-113\u5728\u4e34\u5e8a\u524d\u6a21\u578b\u4e2d\u663e\u793a\u6297\u80bf\u7624\u6d3b\u6027<\/span><\/p>\n

                        FORMA Therapeutics\u516c\u53f8\u7684\u7814\u7a76\u4eba\u5458\u62a5\u9053\u4e86\u4e00\u79cd\u65b0\u578b\u8102\u80aa\u9178\u5408\u6210\u9176\uff08FASN\uff09\u6291\u5236\u5242FT-113\u7684\u53d1\u73b0\u548c\u4e34\u5e8a\u524d\u7814\u7a76\u6570\u636e\u3002\u8be5\u5316\u5408\u7269\u662f\u901a\u8fc7\u5bf9\u4e00\u7c7b\u7279\u5b9a\u7ed3\u6784\u7684\u53d6\u4ee3\u54cc\u55ea\u7c7b\u5316\u5408\u7269\u4f18\u5316\u540e\u5f97\u5230\u7684\uff0c\u4f7f\u5176\u80fd\u591f\u4e0eFASN\u7684KR\u533a\u57df\u7684\u4e00\u4e9b\u836f\u6548\u4f5c\u7528\u4f4d\u70b9\u8fdb\u884c\u76f8\u4e92\u4f5c\u7528\u3002\u5728\u4f53\u5916\u5b9e\u9a8c\u4e2d\uff0cFT-113\uff08IC50 = 0.213 mcM\uff09\u662f\u4e00\u4e2a\u836f\u6548\u548c\u7406\u5316\u6027\u8d28\u6700\u5e73\u8861\u7684\u5316\u5408\u7269\uff0c\u5e76\u88ab\u63a8\u8fdb\u5230\u4f53\u5185\u7814\u7a76\u3002\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76\u8868\u660e\uff0cFT-113\u65e0\u6025\u6027\u6bd2\u6027\uff0c\u5177\u6709\u826f\u597d\u7684\u53e3\u670d\u66b4\u9732\u6548\u679c\u3002\u96cc\u6027Balb\/c\u88f8\u9f20\u548c\u96c4\u6027Sprague-Dawley\u5927\u9f20\u53e3\u670d5 mg\/kg\u7684FT-113\uff0c\u534a\u8870\u671f\u5206\u522b\u4e3a2\u548c3\u5c0f\u65f6\uff0cCmax\u4e3a8.4\u548c33 mcM\uff0cAUC\uff080-8h\uff09\u4e3a46\u548c440 mcM\u2022h\uff0c\u751f\u7269\u5229\u7528\u5ea6\u5206\u522b\u4e3a95%\u548c84%\u3002\u5728\u4f53\u5185\u5b9e\u9a8c\u4e2d\uff0cFT-113\u7684\u836f\u6548\u5728\u5c0f\u9f20\u76ae\u4e0b\u79fb\u690d\u4eba\u7c7b\u764c\u7ec6\u80de\u682aMV-411\u7684\u6a21\u578b\u4e2d\u8fdb\u884c\u4e86\u8bc4\u4f30\u3002\u7ed3\u679c\u8868\u660e\uff0c\u4e0e\u9634\u6027\u5bf9\u7167\u76f8\u6bd4\uff0c25 mg\/kg\u548c50mg\/kg\u7684FT-113\u6cbb\u7597\u7ec4\u5728\u6cbb\u759716\u5929\u540e\u80bf\u7624\u751f\u957f\u6291\u5236\u7387\u5206\u522b\u4e3a32%\u548c50%\u3002\u4e0a\u8ff0\u53d1\u73b0\u8868\u660e\uff0c\u65b0\u578bFASN\u6291\u5236\u5242FT-113\u6709\u671b\u6210\u4e3a\u4e00\u79cd\u6f5c\u5728\u7684\u764c\u75c7\u65b0\u6cbb\u7597\u65b9\u6cd5\uff0c\u6709\u5fc5\u8981\u5bf9\u5176\u8fdb\u884c\u8fdb\u4e00\u6b65\u7814\u7a76\u3002\uff08Martin, M.W. et al.Bioorg Med Chem Lett 2019, 29 (8): 1001\uff09\u3002<\/span><\/p>\n

                        \"2019\u5e743\u6708\u836f\u7269\u5feb\u8baf\u2014\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\"<\/p>\n

                        \u56fe\u4e3aFT-113\u7684\u7ed3\u6784<\/span><\/span>
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                        2019\u5e743\u670822\u65e5\uff0c\u9965\u997f\u7684\u764c\u7ec6\u80de\u5982\u4f55\u751f\u957f\uff1f<\/span><\/p>\n

                        \u764c\u7ec6\u80de\u4e25\u91cd\u4f9d\u8d56\u6c28\u57fa\u9178\u8c37\u6c28\u9170\u80fa\u6765\u4fc3\u8fdb\u5b83\u4eec\u7684\u5feb\u901f\u751f\u957f\uff0c\u4e8b\u5b9e\u4e0a\uff0c\u7ec6\u80de\u5185\u7684\u8c37\u6c28\u9170\u80fa\u751a\u81f3\u4f1a\u88ab\u8017\u5c3d\uff0c\u6b64\u65f6\u79f0\u4e4b\u4e3a\u8c37\u6c28\u9170\u80fa\u9965\u997f\u72b6\u6001\u3002\u5373\u4f7f\u5728\u7f3a\u4e4f\u8c37\u6c28\u9178\u7684\u60c5\u51b5\u4e0b\uff0c\u901a\u8fc7\u4e0a\u8c03p53\uff0c\u764c\u7ec6\u80de\u4e5f\u80fd\u7ee7\u7eed\u751f\u957f\u3002\u52a0\u5dde\u5927\u5b66\u6b27\u6587\u5206\u6821\u7684\u7814\u7a76\u4eba\u5458\u5df2\u7ecf\u8bc1\u660e\uff0c\u8fd9\u662f\u7531\u4e8ep53\u4e0a\u8c03\u4e86\u7cbe\u6c28\u9178\u8f6c\u8fd0\u4f53\u6240\u81f4\u3002\u7cbe\u6c28\u9178\u5185\u6d41\u7684\u589e\u52a0\u5bf9\u8c37\u6c28\u9170\u80fa\u4ee3\u8c22\u7684\u5f71\u54cd\u4e0d\u5927\u3002\u76f8\u53cd\uff0c\u7cbe\u6c28\u9178\u80fd\u591f\u76f4\u63a5\u6fc0\u6d3b\u54fa\u4e73\u52a8\u7269\u96f7\u5e15\u9709\u7d20\u9776\u86cb\u767d\uff08mTOR\uff09\u590d\u5408\u7269\uff0c\u8be5\u590d\u5408\u7269\u80fd\u591f\u611f\u77e5\u7ec6\u80de\u7684\u8425\u517b\u6c34\u5e73\uff0c\u5e76\u6839\u636e\u5176\u8425\u517b\u72b6\u6001\u9a71\u52a8\u7ec6\u80de\u751f\u957f\u7684\u51b3\u7b56\u3002\u201c\u603b\u7684\u6765\u8bf4\uff0c\u8fd9\u9879\u5de5\u4f5c\u63cf\u8ff0\u4e86\u8c37\u6c28\u9170\u80fa\u7f3a\u4e4f\u5bfc\u81f4\u7684\u4fe1\u53f7\u673a\u5236\uff0c\u5305\u542b\u4e86\u8bb8\u591a\u5728\u764c\u7ec6\u80de\u4e2d\u7a81\u53d8\u7684\u4e3b\u8981\u80fd\u91cf\u4f20\u611f\u5668\uff0c\u201d\u4f5c\u8005\u5199\u9053\u3002\u201c\u6211\u4eec\u53d1\u73b0\u4e86\u4e00\u4e2a\u7531p53\u8bf1\u5bfc\u7684\u57fa\u56e0\uff0c\u5b83\u5728\u8c37\u6c28\u9170\u80fa\u9965\u997f\u72b6\u6001\u4e0b\u80fd\u591f\u6444\u53d6\u7cbe\u6c28\u9178\uff0c\u4ee5\u7ef4\u6301\u7531mTORC1\u4ecb\u5bfc\u7684\u7ec6\u80de\u751f\u957f\u548c\u589e\u6b96\u80fd\u529b\u3002\uff08Lowman, X.H. et al.  Rep 2019, 26(11): 3051\uff09\u3002<\/span><\/p>\n


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                        2019\u5e743\u670813\u65e5\uff0c\u827e\u4f2f\u7ef4\u516c\u53f8\u53d1\u73b0\u65b0\u7684Mcl-1\u6291\u5236\u5242<\/span><\/span>
                        <\/p>\n

                        AbbVie\u516c\u53f8\u65e5\u524d\u53d1\u73b0\u4e86\u8bf1\u5bfc\u9ad3\u7ec6\u80de\u767d\u8840\u75c5\u7ec6\u80de\u5206\u5316\u86cb\u767dMcl-1\u7684\u6291\u5236\u5242\uff0c\u6709\u671b\u7528\u4e8e\u6cbb\u7597\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u3002\u4ee3\u8868\u5316\u5408\u7269\u5728TR-FRET\u7ade\u4e89\u7ed3\u5408\u5b9e\u9a8c\u4e2d\uff0c\u5bf9GST\u6807\u8bb0\u7684Mcl-1\u7684Ki\u4e3a0.185 nM\uff08\u65e0\u4eba\u8840\u6e05\uff09\u548c0.776 nM\uff0810%\u4eba\u8840\u6e05\uff09\u3002\u5728Titer-Glo\u6d4b\u8bd5\u4e2d\uff0c\u5316\u5408\u7269\u5bf9\u4eba\u9aa8\u9ad3\u7624AMO-1\u7ec6\u80de\u548cNCI-H929\u7ec6\u80de\u7684IC50\u5206\u522b\u4e3a0.0000488 mcM\u548c0.000156 mcM\u3002\u5316\u5408\u7269\uff08\u6bcf\u65e5\u4e00\u6b21\u9759\u8109\u6ce8\u5c046.25 mg\/kg\uff09\u80fd\u591f\u6291\u5236\u548c\u5ef6\u7f13\u643a\u5e26AMO-1\u80bf\u7624\u5f02\u79cd\u79fb\u690d\u7684\u514d\u75ab\u7f3a\u9677SCID\/bg\u96cc\u9f20\u7684\u80bf\u7624\u751f\u957f\uff08TGImax = 75%\uff0c TGD = 67%\uff09\u3002\uff08\u8be6\u89c1\u4e13\u5229WO 2019035927\uff09\u3002<\/span><\/p>\n

                        \"2019\u5e743\u6708\u836f\u7269\u5feb\u8baf\u2014\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\"<\/p>\n

                        \u56fe\u4e3a\u4e13\u5229WO 2019035927\u4e2d\u4ee3\u8868\u5316\u5408\u7269\u7684\u7ed3\u6784<\/span><\/span><\/p>\n


                        <\/p>\n

                        \u80bf\u7624\u514d\u75ab\u7597\u6cd5<\/span><\/strong><\/span><\/span><\/strong><\/p>\n

                        2019\u5e743\u670825\u65e5\uff0c\u6eb6\u7624\u547c\u80a0\u5b64\u75c5\u6bd2\u5bf9\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u6709\u6cbb\u7597\u4f5c\u7528<\/span><\/p>\n

                        \u97e9\u56fd\u851a\u5c71\u5927\u5b66\u533b\u5b66\u9662\u7684\u79d1\u5b66\u5bb6\u5229\u7528\u524d\u5217\u817a\u764c\u7ec6\u80de\u7cfb\u548c\u5f02\u79cd\u79fb\u690d\u6a21\u578b\u8fdb\u884c\u7684\u4e00\u9879\u4e34\u5e8a\u524d\u7814\u7a76\u8868\u660e\uff0c\u6eb6\u7624\u547c\u80a0\u5b64\u75c5\u6bd2\u5177\u6709\u6297\u80bf\u7624\u4f5c\u7528\u3002\u5728\u4f53\u5916\u7814\u7a76\u4e2d\uff0c\u6eb6\u7624\u547c\u80a0\u5b64\u75c5\u6bd2\u964d\u4f4e\u4e86\u60a3\u8005\u6765\u6e90\u7684\u524d\u5217\u817a\u764c\u7ec6\u80dePC3\u3001LNCaP\u3001DU145\u300122Rv1\u3001TRAMP-C1\u548c\u53bb\u52bf\u8010\u836f\u524d\u5217\u817a\u764c\u7ec6\u80de\uff08CRPC\uff09\u7684\u751f\u957f\u3002\u572822Rv1\u548cLNCaP\u7ec6\u80de\u4e2d\uff0c\u968f\u7740\u547c\u80a0\u5b64\u75c5\u6bd2\u7684\u611f\u67d3\u548c\u51cb\u4ea1\uff0c\u53ef\u89c2\u5bdf\u5230\u96c4\u6fc0\u7d20\u53d7\u4f53\u4fe1\u53f7\u7684\u6291\u5236\u548c\u524d\u5217\u817a\u7279\u5f02\u6027\u6297\u539f\u7684\u51cf\u5c11\u3002\u547c\u80a0\u5b64\u75c5\u6bd2\u662f\u4e00\u79cd\u80fd\u591f\u5728\u80bf\u7624\u7ec6\u80de\u4e2d\u7279\u5f02\u6027\u590d\u5236\u5e76\u6fc0\u6d3bRAS\u901a\u8def\u7684\u75c5\u6bd2\uff0c\u4e0a\u8ff0\u6240\u6709\u7ec6\u80de\u7cfb\u90fd\u8bc1\u660e\u4e86\u8fd9\u4e00\u70b9\uff0c\u8868\u660e\u547c\u80a0\u5b64\u75c5\u6bd2\u5177\u6709\u6f5c\u5728\u7684\u6cbb\u7597\u4f5c\u7528\u3002\u572822Rv1\u7ec6\u80de\u7684\u5c0f\u9f20\u5f02\u79cd\u79fb\u690d\u6a21\u578b\u548cTRAMP-C1\u7ec6\u80de\u7684\u540c\u6e90\u6a21\u578b\u4e2d\uff0c\u7624\u5185\u6ce8\u5c04\u4e2d\u4f4d\u611f\u67d3\u5242\u91cf\u4e3a2 x 10(8)\u7684\u547c\u80a0\u5b64\u75c5\u6bd2\uff0c\u80fd\u591f\u663e\u8457\u51cf\u8f7b\u80bf\u7624\u91cd\u91cf\uff0c\u6548\u679c\u4e0e\u591a\u897f\u7d2b\u6749\u9187\u76f8\u8fd1\u3002\u8be5\u7597\u6cd5\u5bf9\u5176\u4ed6\u5668\u5b98\u65e0\u611f\u67d3\uff0c\u4e14\u5bf9\u4f53\u91cd\u65e0\u5f71\u54cd\u3002\uff08Han, J.H. et al. 34th Congr Eur Assoc Urol (March 15-19, Barcelona) 2019, Abst 858\uff09\u3002<\/span><\/p>\n


                        <\/p>\n

                        2019\u5e743\u67081\u65e5\uff0c\u5b89\u8fdb\u53d1\u8868AMG-160\u79ef\u6781\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u6570\u636e<\/span><\/p>\n

                        \u5b89\u8fdb\u516c\u53f8\u53d1\u8868\u4e86AMG-160\u7684\u4e34\u5e8a\u524d\u6570\u636e\uff0c\u8fd9\u662f\u4e00\u79cd\u5b8c\u5168\u4eba\u6e90\u7684\u3001\u957f\u534a\u8870\u671f\u7684\u4e0b\u4e00\u4ee3\u53cc\u7279\u5f02\u6027T\u7ec6\u80de\u589e\u5f3a\u5242\uff08BiTE\uff09\uff0c\u9776\u5411\u80bf\u7624\u7ec6\u80de\u4e0a\u7684\u524d\u5217\u817a\u7279\u5f02\u6027\u819c\u6297\u539f\uff08PSMA\uff09\u548cT\u7ec6\u80de\u4e0a\u7684CD3\u3002AMG-160\u7531\u4e24\u4e2a\u4e32\u8054\u5355\u94fe\u53ef\u53d8\u7247\u6bb5\u878d\u5408\u5230Fc\u57df\u7ec4\u6210\u3002\u5b83\u901a\u8fc7\u7ed3\u5408\u4eba\u7c7b\u548c\u975e\u4eba\u7c7b\u7075\u957f\u7c7b\u52a8\u7269\u7684PSMA\u548cCD3\uff0c\u81f4\u4f7fT\u7ec6\u80de\u7684\u6d3b\u5316\u589e\u6b96\u4ee5\u53ca\u7ec6\u80de\u56e0\u5b50\u7684\u4ea7\u751f\u3002\u5728\u4f53\u5916\u5b9e\u9a8c\u4e2d\uff0cAMG-160\u663e\u793a\u4e86\u91cd\u5b9a\u5411T\u7ec6\u80de\u7684\u80fd\u529b\uff0c\u80fd\u591f\u6740\u6b7bPSMA\u9633\u6027\u7684\u764c\u7ec6\u80de\u7cfb\uff0c\u5305\u62ecPSMA\u6c34\u5e73\u8f83\u4f4e\u6216\u96c4\u6fc0\u7d20\u975e\u4f9d\u8d56\u6027\u4fe1\u53f7\u4f4e\u7684\u7ec6\u80de\u3002\u5728\u524d\u5217\u817a\u764c\u5f02\u79cd\u79fb\u690d\u6a21\u578b\u8bc4\u4f30\u4e2d\uff0c\u6bcf\u5468\u7ed9\u4e88AMG-160\u53ef\u8868\u73b0\u51fa\u663e\u8457\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\u5728\u975e\u4eba\u7075\u957f\u7c7b\u52a8\u7269\u4e2d\u8fdb\u884c\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u548c\u836f\u6548\u5b66\u7814\u7a76\u8868\u660e\u5176\u534a\u8870\u671f\u7ea6\u4e3a1\u5468\u3002\u57fa\u4e8ePK\u6027\u8d28\uff0c\u9884\u6d4b\u4eba\u4f53\u7684\u7ed9\u836f\u5468\u671f\u5e94\u4e3a\u6bcf\u4e24\u5468\u7ed9\u836f\u4e00\u6b21\u3002\u6b64\u5916\uff0cAMG-160\u53ef\u8bf1\u53d1\u4f53\u5185BiTE\u9776\u6807\u52df\u96c6\uff0c\u5305\u62ec\u77ac\u65f6T\u7ec6\u80de\u6d3b\u5316\u548c\u8840\u6db2\u4e2d\u7ec6\u80de\u56e0\u5b50\u7684\u91ca\u653e\uff0c\u4e14\u5728\u5df2\u77e5\u8868\u8fbePSMA\u7684\u591a\u4e2a\u5668\u5b98\u4e2d\u68c0\u6d4b\u5230\u6df7\u5408\u7ec6\u80de\u6d78\u6da6\u3002\u5728\u5b89\u5168\u6027\u65b9\u9762\uff0cAMG-160\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u5728\u521d\u6b21\u5242\u91cf\u5f15\u8d77\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u540e\u53ef\u4ee5\u9010\u6b65\u51cf\u5c11\u5242\u91cf\u3002\u4e0a\u8ff0\u53d1\u73b0\u8868\u660e\uff0cAMG-160\u662f\u4e00\u79cd\u5bf9PSMA\u9633\u6027\u80bf\u7624\u7ec6\u80de\u5177\u6709\u7279\u5f02\u6027\u7684\u957f\u534a\u8870\u671fBiTE\u3002\u76ee\u524d\u6b63\u8ba1\u5212\u8fdb\u884cI\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u8bc4\u4f30\u5176\u5728\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u524d\u5217\u817a\u764c\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002\uff08Bailis, J. et al. Genitourin Cancers Symp (Feb 14-16, San Francisco) 2019, Abst 301\uff09\u3002<\/span><\/p>\n


                        <\/p>\n

                        \u5fc3\u8840\u7ba1\u75be\u75c5<\/span><\/strong><\/span><\/span><\/strong><\/p>\n

                        2019\u5e743\u670826\u65e5\uff0cREDUCE-IT\u7814\u7a76\u8bc1\u5b9eVascepa\u53ef\u51cf\u5c11\u7f3a\u8840\u4e8b\u4ef6<\/span><\/p>\n

                        Vascepa\uff08\u4e8c\u5341\u78b3\u4e94\u70ef\u9178\uff08EPA\uff09\u4e59\u916f\uff0cAmarin\u516c\u53f8\uff09\u5728\u4e00\u9879\u540d\u4e3aREDUCE-IT\u7684\u7814\u7a76\u4e2d\u8fbe\u5230\u4e86\u964d\u4f4e\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u9996\u6b21\u53d1\u751f\u7387\u7684\u4e3b\u8981\u590d\u5408\u4e34\u5e8a\u7ec8\u70b9\uff0c\u5305\u62ec\u975e\u81f4\u6b7b\u6027\u5fc3\u808c\u6897\u6b7b\u3001\u975e\u81f4\u6b7b\u6027\u5352\u4e2d\u3001\u51a0\u72b6\u52a8\u8109\u8840\u7ba1\u91cd\u5efa\u6216\u4f4f\u9662\u6cbb\u7597\u4e0d\u7a33\u5b9a\u6027\u5fc3\u7ede\u75db\u3002\u8be5\u7814\u7a76\u7eb3\u5165\u4e86\u7ecf\u4ed6\u6c40\u7c7b\u836f\u7269\u6cbb\u7597\u540e\u7684\u51718179\u4f4d\u9ad8\u7518\u6cb9\u4e09\u916f\u8840\u75c7\u60a3\u8005\uff0c\u901a\u8fc7\u968f\u673a\u53cc\u76f2\u5206\u4e3a\u6cbb\u7597\u7ec4\u548c\u5b89\u6170\u5242\u7ec4\uff0c\u6cbb\u7597\u7ec4\u6bcf\u5929\u670d\u75284g Vascepa\u3002\u4f5c\u4e3a\u6b21\u8981\u590d\u5408\u7ec8\u70b9\u7684\u4e3b\u8981\u5fc3\u8840\u7ba1\u4e0d\u826f\u4e8b\u4ef6\uff08MACE\uff0c\u5305\u62ec\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u3001\u975e\u81f4\u6b7b\u6027\u5fc3\u808c\u6897\u6b7b\u548c\u975e\u81f4\u6b7b\u6027\u5352\u4e2d\uff09\u7684\u9996\u6b21\u53d1\u751f\u7387\u4e5f\u5f97\u5230\u4e86\u964d\u4f4e\u3002\u5728\u9884\u5148\u6307\u5b9a\u7684\u5206\u6790\u4e2d\uff0c\u4e3b\u8981\u7ec8\u70b9\u662f\u7531\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u3001\u975e\u81f4\u6b7b\u6027\u5fc3\u808c\u6897\u6b7b\u3001\u975e\u81f4\u6b7b\u6027\u5352\u4e2d\u3001\u51a0\u72b6\u52a8\u8109\u8840\u8fd0\u91cd\u5efa\u6216\u4f4f\u9662\u6cbb\u7597\u4e0d\u7a33\u5b9a\u5fc3\u7ede\u75db\u7b49\u56e0\u7d20\u6784\u6210\u7684\u9996\u6b21\u53ca\u540e\u7eed\u53d1\u751f\u7684\u7f3a\u8840\u6027\u4e8b\u4ef6\u7684\u603b\u548c\uff0c\u5e73\u5747\u968f\u8bbf\u65f6\u95f4\u4e3a4.9\u5e74\u3002\u7edf\u8ba1\u663e\u793a\uff0c\u9996\u6b21\u4e3b\u8981\u7ec8\u70b9\u4e8b\u4ef6\u53d1\u751f1,606\u4f8b\uff0855.2%\uff09\uff0c\u7ee7\u53d1\u7684\u4e3b\u8981\u7ec8\u70b9\u4e8b\u4ef6\u4e3a1,303\u4f8b\uff0844.8%\uff09\uff0c\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0cVascepa\u7684\u603b\uff08\u9996\u6b21\u548c\u7ee7\u53d1\uff09\u4e3b\u8981\u7ec8\u70b9\u4e8b\u4ef6\u53d1\u751f\u7387\u4ece\u6bcf1000\u540d\u60a3\u8005\u5e7489\u4f8b\u964d\u81f361\u4f8b\uff08\u53d1\u751f\u7387\u6bd4\u4e3a0.70\uff09\uff0c\u6cbb\u7597\u51cf\u5c11\u4e86\u4e3b\u8981\u7ec8\u70b9\u4e2d\u5404\u9879\u5355\u72ec\u6307\u6807\u7684\u53d1\u751f\u7387\u3002\u5728\u6b21\u8981\u7ec8\u70b9MACE\u7684\u53d1\u751f\u7387\u4e2d\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0cEPA\u4e59\u916f\u4ece\u6bcf1000\u4f8b44\u4e2a\u964d\u81f332\u4e2a\uff08\u53d1\u751f\u7387\u6bd4\u4e3a0.72\uff09\u3002\u6b64\u5916\uff0c\u7814\u7a76\u8bc1\u5b9eEPA\u4e59\u916f\u7684\u8010\u53d7\u6027\u826f\u597d\u3002REDUCE-IT\u4e34\u5e8a\u7814\u7a76\u7684\u7ed3\u679c\u8868\u660e\uff0cEPA\u4e59\u916f\u9664\u964d\u4f4e\u7518\u6cb9\u4e09\u916f\u5916\uff0c\u8fd8\u53ef\u80fd\u6709\u591a\u79cd\u4f5c\u7528\u673a\u5236\u3002\uff08Bhatt, D.L. et al. J Am Coll Cardiol 2019, Advanced publication\uff09\u3002<\/span><\/p>\n

                        \"2019\u5e743\u6708\u836f\u7269\u5feb\u8baf\u2014\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\"<\/p>\n

                        \u56fe\u4e3aIcosapent ethyl ester\u7ed3\u6784<\/span><\/span><\/p>\n


                        <\/p>\n

                        \u836f\u7269\u8bbe\u8ba1\u53ca\u836f\u7269\u91ca\u653e\u6280\u672f<\/span><\/strong><\/span><\/span><\/strong><\/span><\/p>\n

                        2019\u5e743\u670812\u65e5\uff0c\u542c\u529b\u635f\u4f24\u7684\u57fa\u56e0\u7597\u6cd5\u5728\u6210\u5e74\u8001\u9f20\u8eab\u4e0a\u6709\u6548<\/span><\/p>\n

                        \u542c\u529b\u635f\u4f24\u662f\u4eba\u7c7b\u6700\u5e38\u89c1\u7684\u611f\u5b98\u7f3a\u9677\uff0c\u5b83\u6df1\u523b\u5f71\u54cd\u7740\u793e\u4f1a\u878d\u5408\u3001\u6559\u80b2\u7a0b\u5ea6\u548c\u751f\u6d3b\u8d28\u91cf\u3002\u76ee\u524d\u5df2\u6709\u57fa\u56e0\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597\u7531\u57fa\u56e0\u7f3a\u9677\u5bfc\u81f4\u542c\u529b\u635f\u5931\u7684\u7814\u7a76\u3002\u7136\u800c\uff0c\u8fc4\u4eca\u5df2\u53d1\u8868\u7684\u7814\u7a76\u5927\u90fd\u4f7f\u7528\u65b0\u751f\u5c0f\u9f20\u4f5c\u4e3a\u7814\u7a76\u5bf9\u8c61\uff0c\u8fd9\u4e9b\u5c0f\u9f20\u7684\u5185\u8033\u5c1a\u672a\u53d1\u80b2\u5b8c\u5168\uff0c\u8fd9\u79cd\u7597\u6cd5\u662f\u5426\u9002\u7528\u4e8e\u6210\u5e74\u52a8\u7269\u4ecd\u672a\u5f97\u5230\u8bc1\u5b9e\u3002\u8fd1\u65e5\uff0c\u7231\u8377\u534e\u5927\u5b66\u7684\u4e00\u4e2a\u7814\u7a76\u5c0f\u7ec4\u62a5\u544a\u8bf4\uff0c\u4ed6\u4eec\u6210\u529f\u5730\u6cbb\u7597\u4e86\u6210\u5e74\u8001\u9f20\u7684\u542c\u529b\u635f\u4f24\u6a21\u578b\u3002\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u4e86\u4e00\u79cd\u65b9\u6cd5\u6765\u4f20\u9012\u4e00\u79cd\u57fa\u56e0\uff0c\u8fd9\u79cd\u57fa\u56e0\u5728\u5185\u8033\u7ed3\u6784\u5df2\u7ecf\u9aa8\u8d28\u758f\u677e\u7684\u6210\u5e74\u8001\u9f20\u8eab\u4e0a\u88ab\u8bc1\u5b9e\u6709\u6548\uff0c\u89e3\u51b3\u4e86\u4ee5\u5f80\u4f20\u9012\u57fa\u56e0\u9762\u4e34\u7684\u4e3b\u8981\u6311\u6218\u3002\u5229\u7528\u4ed6\u4eec\u7684\u6a21\u578b\uff0c\u7814\u7a76\u4eba\u5458\u8bc1\u660e\u57fa\u56e0\u6cbb\u7597\u53ef\u4ee5\u7ea0\u6b63\u6210\u5e74\u52a8\u7269\u7531\u4e8e\u7f3a\u4e4fTmc\u57fa\u56e0\u800c\u5bfc\u81f4\u7684\u5931\u806a\u3002\u4f5c\u8005\u5199\u9053\uff0c\u201c\u5229\u7528\u57fa\u56e0\u6cbb\u7597\u6210\u719f\u5c0f\u9f20\u8033\u7ed3\u6784\u7f3a\u9677\u7684\u6210\u529f\uff0c\u4e3a\u5176\u8f6c\u5316\u81f3\u4eba\u7c7b\u7814\u7a76\u8fc8\u51fa\u4e86\u91cd\u8981\u7684\u4e00\u6b65\u3002\uff08Yoshimura, H. et al. Mol Ther 2019, 27(3): 681\uff09\u3002<\/span><\/p>\n


                        <\/p>\n

                        \u5185\u5206\u6ccc\u7cfb\u7edf\u75be\u75c5<\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/p>\n

                        2019\u5e743\u67086\u65e5\uff0c\u6768\u68ee\u516c\u53f8\u53d1\u73b0\u65b0\u7684\u524d\u5217\u817a\u7d20EP3\u53d7\u4f53\u62ee\u6297\u5242<\/span><\/span><\/p>\n

                        Janssen\u5236\u836f\u516c\u53f8\u53d1\u73b0\u4e86\u4e00\u7c7b\u5421\u5576-2-\u916e\u7c7b\u884d\u751f\u7269\u4f5c\u4e3a\u524d\u5217\u817a\u6837EP3\u53d7\u4f53\u62ee\u6297\u5242\uff0c\u6709\u671b\u7528\u4e8e\u6cbb\u7597\u53e3\u670d\u7cd6\u8010\u91cf\u53d7\u635f\uff08\u7cd6\u5c3f\u75c5\u524d\u671f\uff09\u3001\u7a7a\u8179\u8840\u7cd6\u5347\u9ad8\u30012\u578b\u7cd6\u5c3f\u75c5\u548cX\u7efc\u5408\u5f81\uff08\u4ee3\u8c22\u7efc\u5408\u5f81\uff09\u3002\u5728\u653e\u5c04\u6027\u914d\u4f53\u7ed3\u5408\u8bd5\u9a8c\u4e2d\uff0c\u4ee3\u8868\u5316\u5408\u7269\u80fd\u591f\u6291\u5236[3H]-PGE2\u4e0e\u4eba\u7c7bEP3\u53d7\u4f53\u7684\u7ed3\u5408\uff08Ki = 0.001 mcM\uff09\u3002\u5728TR-FRET cAMP\u5b9e\u9a8c\u4e2d\uff0c\u5316\u5408\u7269\u5bf9CHO\u7ec6\u80de\u8868\u8fbe\u7684\u4ebaEP3\u53d7\u4f53\u5177\u6709\u62ee\u6297\u4f5c\u7528\uff08IC50 = 0.002 mcM\uff09\u3002\uff08\u8be6\u89c1\u4e13\u52292019047961\uff09\u3002<\/span><\/p>\n

                        \"2019\u5e743\u6708\u836f\u7269\u5feb\u8baf\u2014\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\"<\/p>\n

                        \u56fe\u4e3a\u4e13\u5229US 2019047961\u4e2d\u4ee3\u8868\u5316\u5408\u7269\u7684\u7ed3\u6784<\/span><\/span><\/p>\n


                        <\/p>\n

                        \u773c\u79d1\u75be\u75c5<\/span><\/strong><\/span><\/span><\/strong><\/span><\/p>\n

                        2019\u5e743\u670815\u65e5\uff0cAhR\u88ab\u8bc1\u5b9e\u53ef\u6210\u4e3a\u6cbb\u7597\u8001\u5e74\u6027\u9ec4\u6591\u53d8\u6027\u7684\u9776\u6807<\/span><\/p>\n

                        \u6839\u636e\u5148\u524d\u7684\u62a5\u9053\uff0c\u82b3\u57fa\u78b3\u6c22\u5316\u5408\u7269\u53d7\u4f53\uff08AhR\uff09\u7684\u7f3a\u5931\u4e0e\u6fc0\u5149\u8bf1\u5bfc\u7684\u8109\u7edc\u819c\u65b0\u751f\u8840\u7ba1\u75c5\u53d8\u4e25\u91cd\u7a0b\u5ea6\u7684\u6076\u5316\u76f8\u5173\u3002\u7814\u7a76\u4eba\u5458\u7b5b\u9009\u4e86\u80fd\u591f\u6fc0\u6d3b\u8109\u7edc\u819c\u5185\u76ae\u7ec6\u80de\u4e2dAhR\u7684\u914d\u4f53\uff0c\u5e76\u5728\u4f53\u5185\u548c\u4f53\u5916\u6d4b\u8bd5\u4e86\u5b83\u4eec\u5bf9\u8840\u7ba1\u751f\u6210\u529f\u80fd\u7684\u5f71\u54cd\u3002\u7814\u7a76\u53d1\u73b0\uff0cAhR\u7684\u914d\u4f53\u80fd\u8bf1\u5bfc\u5176\u9776\u57fa\u56e0CYP1A2\u3001CYP1B1\u7684\u542f\u52a8\u5b50\u8868\u8fbe\u6d3b\u6027\u63d0\u9ad85 ~ 12\u500d\uff0c\u540c\u65f6\u89c2\u5bdf\u5230\u4e86\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09\u8bf1\u5bfc\u7684\u5185\u76ae\u7ec6\u80de\u8fc1\u79fb\u548c\u8840\u7ba1\u751f\u6210\u7684\u6291\u5236\u4f5c\u7528\u3002\u5728\u5c0f\u9f20\u4e2d\uff0c\u6bcf\u65e5\u8179\u8154\u5185\u7ed9\u4e88\u6d3b\u6027\u7684AhR\u914d\u4f53\uff0c\u53ef\u4f7f\u6fc0\u5149\u8bf1\u5bfc\u7684\u635f\u4f24\u76f8\u6bd4\u5e38\u89c4\u836f\u7269\u51cf\u8f7b55-57%\u3002\u7531\u4e8eAhR\u7684\u6fc0\u6d3b\uff0c\u8109\u7edc\u819c\u65b0\u751f\u8840\u7ba1\u75c5\u53d8\u4e2dIV\u578b\u80f6\u539f\u7684\u84c4\u79ef\u51cf\u5c11\u4e8633-37%\uff0c\u5faa\u73af\u708e\u6027\u539f\u7ec6\u80de\u56e0\u5b50\u6c34\u5e73\u4e5f\u663e\u8457\u964d\u4f4e\u964d\u4f4e\uff08P < 0.01\uff09\u3002\u8be5\u7814\u7a76\u7ed3\u679c\u63ed\u793a\u4e86AhR\u5728\u8109\u7edc\u819c\u65b0\u751f\u8840\u7ba1\u75c5\u53d8\u75c5\u7406\u8c03\u63a7\u4e2d\u7684\u4f5c\u7528\uff0c\u4ee5\u5176\u4f5c\u4e3a\u836f\u7269\u9776\u70b9\u53ef\u80fd\u6709\u52a9\u4e8e\u6cbb\u7597\u65b0\u751f\u8840\u7ba1\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\u3002<\/span>\uff08Choudhary, M. et al.14th Sci Meet Assoc OculPharmacolTher (AOPT) (March 7-10, New Orleans) 2019,Abst 5\uff09\u3002<\/span><\/p>\n


                        <\/p>\n

                        \u4ee3\u8c22\u7c7b\u75be\u75c5<\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/strong><\/span><\/p>\n

                        2019\u5e743\u67086\u65e5\uff0c\u4e3a\u5de8\u566c\u7ec6\u80de\u63d0\u4f9b\u8102\u80aa\u7684\u65b0\u9014\u5f84<\/span><\/p>\n

                        \u8102\u80aa\u7ec6\u80de\u4f5c\u4e3a\u80fd\u91cf\u50a8\u5b58\u5668\uff0c\u901a\u8fc7\u9176\u9a71\u52a8\u7684\u8102\u80aa\u5206\u89e3\u8fc7\u7a0b\u91ca\u653e\u8102\u80aa\u9178\u3002\u65e5\u524d\uff0c\u6765\u81ea\u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66\u7684\u79d1\u5b66\u5bb6\u53d1\u73b0\u4e86\u8102\u80aa\u7ec6\u80de\u91ca\u653e\u80fd\u91cf\u7684\u53e6\u4e00\u79cd\u9014\u5f84\uff0c\u8fd9\u79cd\u9014\u5f84\u5bf9\u8102\u80aa\u7ec4\u7ec7\u4e2d\u5de8\u566c\u7ec6\u80de\u7684\u5206\u5316\u548c\u6d3b\u6027\u6709\u91cd\u8981\u7684\u5f71\u54cd\u3002\u7814\u7a76\u5c0f\u7ec4\u53d1\u73b0\uff0c\u8102\u80aa\u7ec6\u80de\u9664\u4e86\u901a\u8fc7\u9176\u4fc3\u8fc7\u7a0b\u91ca\u653e\u8102\u80aa\u9178\u5916\uff0c\u8fd8\u80fd\u901a\u8fc7\u91ca\u653e\u4e00\u79cd\u201c\u5916\u6ccc\u4f53\u5927\u5c0f\u7684\u5145\u6ee1\u8102\u8d28\u7684\u56ca\u6ce1\uff08AdExos\uff09\u201d\uff0c\u4e3a\u9644\u8fd1\u7684\u5de8\u566c\u7ec6\u80de\u63d0\u4f9b\u8102\u8d28\u6765\u6e90\u3002\u6765\u81ea\u7626\u8001\u9f20\u7684\u8102\u80aa\u7ec4\u7ec7\u6bcf\u5929\u901a\u8fc7\u5916\u6ccc\u4f53\u91ca\u653e\u7ea61%\u7684\u8102\u8d28\uff0c\u80a5\u80d6\u52a8\u7269\u4e2d\u7684\u8fd9\u4e00\u901f\u7387\u4e3a\u4e24\u500d\u4ee5\u4e0a\u3002\u201d\u5de8\u566c\u7ec6\u80de\u662f\u8102\u80aa\u7ec4\u7ec7\u4e2d\u6700\u4e30\u5bcc\u7684\u514d\u75ab\u7ec6\u80de\u7c7b\u578b\uff0c\u5360\u80a5\u80d6\u4e2a\u4f53\u514d\u75ab\u7ec6\u80de\u768450%\uff0c\u7531\u5de8\u566c\u7ec6\u80de\u9a71\u52a8\u7684\u708e\u75c7\u4f5c\u7528\u53ef\u5bfc\u81f4\u80a5\u80d6\u4e2a\u4f53\u7684\u5168\u8eab\u6027\u80f0\u5c9b\u7d20\u62b5\u6297\u3002\u5bf9\u8fd9\u4e00\u8c03\u63a7\u8fc7\u7a0b\u7684\u4e86\u89e3\uff0c\u5c06\u4e3a\u5bf9\u6297\u4ee3\u8c22\u7c7b\u75be\u75c5\u63d0\u4f9b\u65b0\u601d\u8def\u3002\uff08Flaherty, S.E. III. et al. Science 2019, 363(6430): 989\uff09\u3002<\/span><\/p>\n


                        <\/p>\n

                        \u808c\u8089\u9aa8\u9abc\u548c\u7ed3\u7f14\u7ec4\u7ec7\u75be\u75c5<\/span><\/strong><\/span><\/span><\/strong><\/span><\/p>\n

                        2019\u5e743\u67084\u65e5\uff0c\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u516c\u53f8\u53d1\u73b0\u6eb6\u8840\u78f7\u8102S1P1\u53d7\u4f53\u6fc0\u52a8\u5242<\/span><\/p>\n

                        \u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u516c\u53f8\u53d1\u73b0\u4e86\u4e00\u7cfb\u5217\u70f7\u57fa\u82ef\u7c7b\u5316\u5408\u7269\u4f5c\u4e3a\u6eb6\u8840\u78f7\u8102S1P1\u53d7\u4f53\u6fc0\u52a8\u5242\uff0c\u6709\u671b\u7528\u4e8e\u6cbb\u7597\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u3001\u5e72\u71e5\u7efc\u5408\u5f81\u3001\u708e\u75c7\u6027\u80a0\u75c5\u3001\u591a\u53d1\u6027\u786c\u5316\u75c7\u548c\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u7b49\u75be\u75c5\u3002\u4ee3\u8868\u5316\u5408\u7269\u5728[35S]GTPgammaS\u7ed3\u5408\u5b9e\u9a8c\u4e2d\uff0c\u5bf9CHO\u7ec6\u80de\u819c\u8868\u8fbe\u7684\u4ebaS1P1\u53d7\u4f53\u8868\u73b0\u51fa\u4eb2\u548c\u529b\uff08EC50 = 41 nM\uff09\uff0c\u4e14\u5bf9S1P3\u53d7\u4f53\uff08EC50 > 30000 nM\uff09\u5177\u6709\u9009\u62e9\u6027\u3002\uff08\u8be6\u89c1WO 2019032632\uff09\u3002<\/span><\/p>\n

                        \"2019\u5e743\u6708\u836f\u7269\u5feb\u8baf\u2014\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\"<\/p>\n

                        \u56fe\u4e3a\u4e13\u5229WO 2019032632\u4e2d\u4ee3\u8868\u5316\u5408\u7269\u7684\u7ed3\u6784<\/span><\/span><\/p>\n


                        <\/p>\n

                        \u80c3\u80a0\u9053\u75be\u75c5<\/span><\/strong><\/span><\/span><\/strong><\/span><\/p>\n

                        2019\u5e743\u670814\u65e5\uff0c\u65b0\u7684\u751f\u7269\u6807\u5fd7\u7269\u53ef\u7528\u4e8e\u9274\u5b9a\u708e\u75c7\u6027\u80a0\u75c5\u7684\u4e25\u91cd\u7a0b\u5ea6<\/span><\/p>\n

                        \u534e\u76db\u987f\u5927\u5b66\u533b\u5b66\u9662\u7684\u7814\u7a76\u4eba\u5458\u9886\u5bfc\u7684\u4e00\u4e2a\u56fd\u9645\u7814\u7a76\u5408\u4f5c\u5c0f\u7ec4\u53d1\u8868\u4e86\u4e00\u9879\u7814\u7a76\uff0c\u63cf\u8ff0\u4e86\u708e\u75c7\u6027\u80a0\u75c5\u5b58\u5728\u4e00\u4e2a\u514d\u75ab-\u51dd\u8840\u57fa\u56e0\u8f74\uff0c\u5176\u4e2d\u7ea4\u6eb6\u9176\u539f\u6fc0\u6d3b\u7269\u6291\u5236\u52421\uff08PAI-1\uff09\u7684\u5347\u9ad8\u4e0e\u4fb5\u88ad\u6027\u66f4\u5f3a\u7684\u75be\u75c5\u76f8\u5173\u3002\u57fa\u56e0\u4e0e\u73af\u5883\u7684\u76f8\u4e92\u4f5c\u7528\u88ab\u8ba4\u4e3a\u662f\u708e\u75c7\u6027\u80a0\u75c5\uff08IBD\uff09\u75c5\u56e0\u7684\u90e8\u5206\u57fa\u7840\uff0c\u4e2d\u5ea6\u81f3\u91cd\u5ea6IBD\u5f80\u5f80\u96be\u4ee5\u6cbb\u7597\u3002\u5bf9\u4e0a\u76ae\u514d\u75ab\u76f8\u5173\u57fa\u56e0\u7f51\u7edc\u8fdb\u884c\u5168\u8f6c\u5f55\u7ec4\u5206\u6790\uff0c\u53ef\u4ee5\u5e2e\u52a9\u786e\u5b9a\u57fa\u56e0\u901a\u8def\uff0c\u53d1\u73b0\u65b0\u7684\u836f\u7269\u9776\u70b9\uff0c\u5e76\u5b9e\u73b0\u5bf9\u75be\u75c5\u7684\u5206\u5c42\u6cbb\u7597\u3002\u8fd9\u9879\u7814\u7a76\u7684\u6570\u636e\u6765\u81ea14\u4e2a\u961f\u5217\u548c1800\u4e2a\u80a0\u9053\u6d3b\u68c0\uff0c\u7ed3\u679c\u53d1\u73b0\u51dd\u8840\u901a\u8def\u57fa\u56e0\u662f\u6f5c\u5728\u7684\u76ee\u6807\u57fa\u56e0\uff08\u5f52\u4e00\u5316\u5bcc\u96c6\u8bc4\u5206\u4e3a1.7\uff0cP = 0.014\uff09\u3002\u7f16\u7801PAI-1\u7684SERPINE1\u57fa\u56e0\u5728\u6d3b\u52a8\u6027IBD\u60a3\u8005\u4e2d\u5bcc\u96c6\uff0c\u800c\u8fd9\u7c7b\u60a3\u8005\u5bf9THF-alpha\u751f\u7269\u5236\u5242\u65e0\u5e94\u7b54\u3002\u5728\u8461\u805a\u7cd6\u786b\u9178\u94a0\uff08DSS\uff09\u8bf1\u5bfc\u7684\u5c0f\u9f20\u7ed3\u80a0\u635f\u4f24\u6a21\u578b\u4e2d\uff0c\u4e0a\u76ae\u7ec6\u80dePAI-1\u7684\u8868\u8fbe\u91cf\u589e\u52a06\u500d\uff1b\u76f8\u6bd4\u4e4b\u4e0b\uff0cDSS\u5904\u7406\u7684SERPINE1-\/-\u5c0f\u9f20\u7c98\u819c\u635f\u4f24\u548c\u708e\u75c7\u660e\u663e\u51cf\u5c11\u3002PAI-1\u80fd\u591f\u6291\u5236\u7ea4\u6eb6\u6027\u86cb\u767d\u9176\u7ec4\u7ec7\u7ea4\u6eb6\u9176\u539f\u6fc0\u6d3b\u7269\uff08tPA\uff09\u3002\u5728tPA\u6572\u9664\u7684\u5c0f\u9f20\u4e2d\uff0c\u673a\u68b0\u7ed3\u80a0\u635f\u4f24\u7684\u6108\u5408\u660e\u663e\u5ef6\u8fdf\u3002\u6b64\u5916\uff0c\u5728\u4f24\u53e3\u6108\u5408\u8bd5\u9a8c\u4e2d\uff0c\u5916\u6e90\u6027tPA\uff08\u800c\u4e0d\u662fPAI-1\uff09\u80fd\u591f\u4fc3\u8fdb\u4f24\u53e3\u6108\u5408\u3002\u56e0\u6b64\uff0c\u635f\u4f24\/\u4fee\u590d\u5e73\u8861\u88ab\u8ba4\u4e3a\u53cd\u6620\u4e86\u7ec4\u7ec7\u5185PAI-1\u4e0e\u6d3b\u6027tPA\u7684\u6bd4\u4f8b\u3002\u5728\u4f53\u5185\u7814\u7a76\u4e2d\uff0cPAI-1\u6291\u5236\u5242MDI-2268\u901a\u8fc7\u589e\u52a0\u6d3b\u6027tPA\u7684\u6bd4\u4f8b\uff0c\u5bf9DSS\u8bf1\u5bfc\u7684\u7ed3\u80a0\u708e\u663e\u793a\u4e86\u4fdd\u62a4\u4f5c\u7528\u3002PAI-1\u5177\u6709\u4fc3\u708e\u4f5c\u7528\uff0c\u53ef\u963b\u6b62tPA\u4ecb\u5bfc\u7684\u5206\u88c2\u5e76\u8fdb\u4e00\u6b65\u6fc0\u6d3b\u6297\u708e\u8f6c\u5316\u751f\u957f\u56e0\u5b50\uff08TGF-beta\uff09\u3002\u5728\u4e34\u5e8a\u6837\u672c\u4e2d\uff0cSERPINE1\u7684\u8868\u8fbe\u4e0e\u75be\u75c5\u6d3b\u8dc3\u7a0b\u5ea6\u76f8\u5173\uff08r = 0.32, P = 0.0025\uff09\uff0c\u53ef\u7528\u4e8e\u533a\u5206\u6d3b\u8dc3\u548c\u975e\u6d3b\u8dc3\u7684\u75be\u75c5\uff0c\u51c6\u786e\u7387\u53ef\u8fbe97.5%\u3002\uff08Kaiko, G.E. et al. Sci Transl Med 2019, 11(482): eaat0852\uff09\u3002<\/span><\/p>\n

                        \"2019\u5e743\u6708\u836f\u7269\u5feb\u8baf\u2014\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\"<\/p>\n

                        \u56fe\u4e3aMDI-2268\u7684\u7ed3\u6784<\/span><\/span><\/p>\n


                        <\/p>\n

                        \u795e\u7ecf\u7cfb\u7edf\u75be\u75c5<\/span><\/strong><\/span><\/span><\/strong><\/span><\/p>\n

                        2019\u5e743\u67081\u65e5\uff0c\u6b66\u7530\u53d1\u73b0\u65b0\u7ed3\u6784\u7684\u9009\u62e9\u6027Nav1.1\u79bb\u5b50\u901a\u9053\u6fc0\u6d3b\u5242<\/span><\/p>\n

                        \u6b66\u7530\u5236\u836f\u516c\u53f8\u7684\u7814\u7a76\u4eba\u5458\u6700\u8fd1\u62a5\u9053\u4e86\u4e00\u7c7b\u65b0\u578b\u76844-\u82ef\u57fa-2-\u5421\u54af\u70f7\u57fa\u70df\u9170\u80fa\u884d\u751f\u7269\u7684\u5408\u6210\u548c\u4f18\u5316\uff0c\u4f5c\u4e3a\u5f3a\u6548\u7684Nav1.1\u79bb\u5b50\u901a\u9053\u6fc0\u6d3b\u5242\uff0c\u4ee3\u8868\u5316\u5408\u7269I\u88ab\u9009\u4e3a\u8be5\u7cfb\u5217\u7684\u4e3b\u8981\u5019\u9009\u5316\u5408\u7269\uff0c\u5b83\u57280.03 mcM\u6d53\u5ea6\u4e0b\u80fd\u591f\u4f7fNav1.1\u7535\u6d41\u8870\u51cf\u65f6\u95f4\u5e38\u6570\uff08tau\uff09\u7684\u589e\u52a0\u3002\u4f7f\u7528Q-patch\u65b9\u6cd5\u5bf9\u5316\u5408\u7269I\u5728Nav1.2\u3001Nav1.3\u3001Nav1.5\u548cNav1.6\u7684\u4e9a\u578b\u9009\u62e9\u6027\u8fdb\u884c\u4e86\u8bc4\u4f30\uff0c\u663e\u793a\u5316\u5408\u7269\u5bf9Nav1.3\u7684\u6fc0\u6d3b\u7a0b\u5ea6\u4f4e\u4e8eNav1.1\uff0c\u4e14\u5728\u6d53\u5ea6\u4e3a10 mcM\u4ee5\u4e0b\u65f6\u5bf9Nav1.2\u3001Nav1.5\u548cNav1.6\u6ca1\u6709\u5f71\u54cd\u3002\u4e0e\u5df2\u62a5\u9053\u7684Nav1.1\u6fc0\u6d3b\u5242\u76f8\u6bd4\uff0c\u5316\u5408\u7269I\u7684\u4e9a\u578b\u9009\u62e9\u6027\u663e\u8457\u63d0\u9ad8\u3002\u4f53\u5185\u7684\u8111\u7ec4\u7ec7\u836f\u4ee3\u52a8\u529b\u5b66\u5206\u6790\u663e\u793a\uff0c\u5c0f\u9f20\u8179\u8154\u7ed9\u4e88\u5316\u5408\u7269\uff0830 mg\/kg\uff09\u53ef\u5bfc\u81f4\u8db3\u591f\u7684\u8111\u66b4\u9732\u91cf\uff08\u7ed9\u836f\u540e1\u5c0f\u65f6\u4e3a193 ng\/g\uff09\uff0c\u76f8\u5f53\u4e8e13nm\u7684\u8111\u5185\u81ea\u7531\u6d53\u5ea6\uff0c\u4e0e\u8be5\u5316\u5408\u7269\u7684\u4f53\u5916\u836f\u6548\u76f8\u5f53\uff0c\u8868\u660e\u5316\u5408\u7269\u53ef\u4f5c\u4e3a\u4e00\u4e2a\u4f53\u5185\u5de5\u5177\u6765\u7814\u7a76\u8be5\u7c7bNav1.1\u6fc0\u6d3b\u5242\u662f\u5426\u80fd\u591f\u5728\u52a8\u7269\u6a21\u578b\u4e2d\u6062\u590dNav1.1\u7684\u529f\u80fd\u548c\u6539\u53d8\u75be\u75c5\u72b6\u6001\u3002\u6b64\u5916\uff0c\u8be5\u5316\u5408\u7269\u5bf9\u591a\u836f\u8010\u836f\u86cb\u767d1\uff08MDR1\uff09\u7684\u819c\u901a\u900f\u6027\u4e3a4\uff08\u5c04\u6d41\u6bd4= 1.0\uff09\uff0c\u9884\u6d4b\u5b83\u53ef\u4ee5\u7a7f\u900f\u4eba\u8840\u8111\u5c4f\u969c\u3002\u57fa\u4e8e\u8fd9\u4e9b\u53d1\u73b0\uff0c\u5316\u5408\u7269I\u88ab\u8ba4\u4e3a\u662f\u4e00\u79cd\u6709\u6f5c\u5728\u5f00\u53d1\u4ef7\u503c\u7684Nav1.1\u6fc0\u6d3b\u5242\uff0c\u53ef\u7528\u4e8e\u7814\u7a76Nav1.1\u901a\u9053\u5728\u5404\u79cd\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u4e2d\u7684\u75c5\u7406\u548c\u751f\u7406\u529f\u80fd\u3002\uff08Miyazaki, T. et al. Bioorg Med Chem Lett 2019, 29 (6): 815\uff09\u3002<\/span><\/p>\n

                         <\/span><\/p>\n

                        \"2019\u5e743\u6708\u836f\u7269\u5feb\u8baf\u2014\u2014\u5e2e\u52a9\u60a8\u53ca\u65f6\u628a\u63e1\u836f\u7269\u7814\u53d1\u52a8\u6001\"<\/p>\n

                        \u56fe\u4e3a\u5316\u5408\u7269I\u7684\u7ed3\u6784<\/span><\/p>\n


                        <\/span><\/p>\n

                        <\/h1>\n

                        \u70b9\u51fb\u3010\u9605\u8bfb\u539f\u6587\u3011<\/span><\/strong>\uff0c\u83b7\u53d6\u4e2d\u82f1\u6587PDF\u7248<\/span>
                        <\/span><\/h1>\n
                        \n

                        \u672c\u6587\u5185\u5bb9\u6458\u81ea\u79d1\u777f\u552f\u5b89\u836f\u7269\u65b0\u95fbBioworld Science\uff0c\u79d1\u777f\u552f\u5b89\u5bf9\u672c\u6587\u7684\u5168\u90e8\u5185\u5bb9\u4ee5\u53ca\u53ef\u80fd\u9644\u5e26\u7684\u5168\u90e8\u8d44\u6599\u62e5\u6709\u5168\u90e8\u77e5\u8bc6\u4ea7\u6743\uff0c\u5e76\u53d7\u6cd5\u5f8b\u4fdd\u62a4\u3002\u7f51\u7edc\u8f6c\u8f7d\u3001\u7f16\u8bd1\u53ca\u5176\u4ed6\u5546\u4e1a\u4f7f\u7528\u8bf7\u8054\u7cfb\u5e02\u573a\u90e8\uff1ayili1@Clarivate.com<\/span><\/p>\n


                        <\/p>\n

                        \n

                        \u5ef6\u4f38\u9605\u8bfb\uff1a<\/span><\/p>\n

                        \u79d1\u777f\u552f\u5b89\u60c5\u62a5\u8ddf\u8e2a\u4e13\u5bb6Bioworld Science\u514d\u8d39\u8bd5\u7528\u5566<\/span><\/a>
                        <\/p>\n<\/blockquote>\n


                        <\/p>\n

                        \n
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                        Bioworld Science \u836f\u7269\u65b0\u95fb<\/span><\/strong><\/span><\/p>\n


                        <\/p>\n

                        \u5468\u4e00\u81f3\u5468\u4e94\u52a8\u6001\u66f4\u65b0\u7684\u836f\u7269\u65b0\u95fb\u548cEMAIL\u8ddf\u8e2a\u63d0\u9192<\/span>
                        <\/p>\n


                        <\/p>\n

                        \u25a0 <\/span> \u6bcf\u5468\u4e00\u81f3\u4e94, Clarivate Analytics\u836f\u7269\u65b0\u95fb\uff08Clarivate Analytics BioWorld Science\uff09\u7cbe\u9009\u6700\u65b0\u3001\u6700\u91cd\u8981\u7684\u836f\u7269\u7814\u53d1\u65b0\u95fb\u5728\u7ebf\u53d1\u5e03\uff0c\u5e76\u4ee5\u7b80\u660e\u627c\u8981\u7684\u683c\u5f0f\u53d1\u9001\u63d0\u9192\u90ae\u4ef6\u81f3\u60a8\u7684\u90ae\u7bb1\uff0c\u5e2e\u52a9\u60a8\u5feb\u901f\u9501\u5b9a\u91cd\u8981\u7684\u65b0\u95fb\u4e8b\u4ef6\u3002<\/span><\/p>\n

                        \u25a0<\/span>  \u60a8\u53ef\u4ee5\u5728\u7ebf\u68c0\u7d22\u6211\u4eec\u6240\u6709\u7684\u65b0\u95fb\u8d44\u6e90\uff0c\u5e76\u8bbe\u5b9a\u68c0\u7d22\u6761\u4ef6\uff08\u9650\u5b9a\u65b0\u95fb\u53d1\u751f\u7684\u65f6\u95f4\u3001\u836f\u540d\u3001\u4e13\u5229\u53f7\u3001\u516c\u53f8\u3001\u5927\u5b66\u3001\u673a\u6784\u3001\u6cbb\u7597\u7c7b\u522b\/\u5206\u7ec4\u3001\u5316\u5408\u7269\u7c7b\u578b\u3001\u4fe1\u606f\u6e90\uff09\u627e\u5230\u4e0e\u60a8\u7814\u7a76\u76f8\u5173\u7684\u5185\u5bb9\u3002\u836f\u7269\u65b0\u95fb\uff08BioWorld Science\uff09\u5185\u5bb9\u53ef\u56de\u6eaf\u81f31996\u5e74\uff0c\u5e76\u53ef\u67e5\u770b\u5316\u5b66\u7ed3\u6784\u5f0f\u3002<\/span><\/p>\n


                        <\/p>\n


                        <\/p>\n

                        \u836f\u7269\u65b0\u95fb\uff08BioWorld Science\uff09\u63d0\u4f9b\u5982\u4e0b\u5185\u5bb9\uff1a<\/span><\/p>\n

                        \u25a0<\/span>  \u4ece\u6d77\u91cf\u4fe1\u606f\u6e90\u4e2d\u603b\u7ed3\u51fa\u7684\u6458\u8981\u62a5\u544a\u3002<\/span><\/p>\n

                        \u25a0<\/span>  \u5728\u5168\u7403\u91cd\u8981\u4f1a\u8bae\u4e2d\u62ab\u9732\u7684\u65b0\u95fb\u4fe1\u606f\u3002<\/span><\/p>\n

                        \u25a0 <\/span> \u6bcf\u5468\u66f4\u65b0\u7684\u90ae\u4ef6\u63d0\u9192\u670d\u52a1\uff0c\u4ee5\u8868\u683c\u7684\u5f62\u5f0f\u544a\u77e5\u60a8\u8fdb\u5165\u4e34\u5e8a\u524d\u5f00\u53d1\u6700\u6709\u524d\u666f\u7684\u5316\u5408\u7269\u3001lead compounds\u548c\u6700\u65b0\u7684\u4f5c\u7528\u673a\u5236\u3002<\/span><\/p>\n

                        \u25a0<\/span>  \u6bcf\u5468\u66f4\u65b0\u7684\u90ae\u4ef6\u63d0\u9192\u670d\u52a1\uff0c\u544a\u77e5\u60a8\u5728\u7814\u836f\u7269\u7814\u53d1\u72b6\u6001\u7684\u53d8\u66f4\u3002<\/span><\/p>\n


                        <\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


                        <\/p>\n

                        \n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

                        \u4e2d\u6587\u7ffb\u8bd1\uff1a\u963f\u6817\u535a\u58eb Daily Drug News \u5df2\u6b63\u5f0f\u66f4\u540d\u4e3aBioWorld Science \u5feb […]<\/p>\n","protected":false},"author":1,"featured_media":82982,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/82981"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=82981"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/82981\/revisions"}],"predecessor-version":[{"id":82990,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/82981\/revisions\/82990"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/82982"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=82981"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=82981"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=82981"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}