{"id":83543,"date":"2019-04-17T00:00:50","date_gmt":"2019-04-17T03:04:11","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/83543\/"},"modified":"2019-04-17T11:04:14","modified_gmt":"2019-04-17T03:04:14","slug":"90eaa7266a","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/83543\/","title":{"rendered":"\u80de\u5185\u86cb\u767d\u6297\u539f–\u751f\u7269\u5236\u54c1\u6297\u80bf\u7624\u9776\u70b9\u7684\u51b0\u5c71\u4e4b\u4e0b"},"content":{"rendered":"
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\u70b9\u51fb\u4e0a\u65b9\u7684<\/span>  \u25b2<\/span> \u6dfb\u52a0\u5173\u6ce8<\/span><\/span><\/p>\n


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\u751f\u7269\u5236\u54c1\u6297\u80bf\u7624\u9776\u70b9\u6297\u539f\u5206\u6790<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u9776\u5411\u6cbb\u7597\u662f\u751f\u7269\u5236\u54c1\u5728\u6297\u80bf\u7624\u9886\u57df\u6709\u522b\u4e8e\u653e\u5316\u7597\u7684\u4e00\u4e2a\u663e\u8457\u7279\u5f81\uff0c\u751f\u7269\u5236\u54c1\u76f4\u63a5\u9776\u5411\u80bf\u7624\u7ec6\u80de\uff0c\u901a\u8fc7\u76f4\u63a5\u6216\u8005\u95f4\u63a5\u7684\u65b9\u5f0f\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u3002\u65e0\u8bba\u751f\u7269\u5236\u54c1\u5982\u6297\u4f53\u76f4\u63a5\u9776\u5411\u80bf\u7624\u7ec6\u80de\u819c\u53d7\u4f53\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\uff0c\u8fd8\u662f\u6297\u4f53\u5076\u8054\u836f\u7269\u901a\u8fc7\u9776\u5411\u80bf\u7624\u8868\u9762\u53d7\u4f53\u5185\u5316\u8fdb\u5165\u80bf\u7624\u7ec6\u80de\u91ca\u653e\u6bd2\u6027\u5206\u5b50\u6740\u6b7b\u80bf\u7624\uff0c\u4ea6\u6216\u901a\u8fc7\u6297\u4f53\u8bc6\u522b\u540e\u8bf1\u5bfc\u514d\u75ab\u7ec6\u80de\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u6740\u4f24\u5982\u5de5\u7a0b\u5316Fc\u7aef\u8bf1\u5bfc\u7684ADCC,CDC\u548cADCP\u4f5c\u7528\uff0cCAR-T\/TCR-T\/CAR-NK\u76f4\u63a5\u9776\u5411\u6740\u4f24\uff0c\u53cc\u7279\u5f02\u6297\u4f53\u5982BiTEsCD3\/anti-antigen\u7b49\u5438\u5f15\u514d\u75ab\u7ec6\u80de\u5728\u80bf\u7624\u7ec6\u80de\u5bcc\u96c6\u6740\u4f24\u3002<\/span><\/p>\n


\u622a\u6b62\u81f32017\u5e745\u6708\uff0c\u6839\u636eWilliamR. Strohl\u7684\u6587\u7ae0\u7edf\u8ba1\u8fdb\u5165\u4e34\u5e8a\u5b9e\u9a8c\u7684\u6297\u4f53\uff0cFc\u878d\u5408\u86cb\u767d\u548c\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u6240\u9488\u5bf9\u7684\u9776\u70b9\u4e00\u5171\u6709351\u4e2a\uff0c\u5728\u80bf\u7624\u9886\u57df\u7684\u9776\u70b9\u5171\u6709175\u4e2a\u3002\u5176\u4e2d\u7ec6\u80de\u8868\u9762\u7684\u53d7\u4f53\uff08\u5355\u900f\u819c\uff09\u6709143\u4e2a\uff0c\u7ea6\u536082%\uff1b\u53ef\u6eb6\u86cb\u767d\u670926\u4e2a\uff0c\u7ea6\u536015%\uff1b\u7ec6\u80de\u8868\u9762\u7684\u591a\u900f\u819c\/GPCR \uff08\u4e03\u900f\u819c\uff09\u53d7\u4f53\u9776\u70b95\u4e2a\uff0c\u7ea6\u53603%\u3002\u9776\u5411\u7ec6\u80de\u8868\u9762\u7684\u53d7\u4f53\u5360\u7edd\u5927\u591a\u6570, \u5bf9\u4e8e\u9776\u70b9\u7684\u9776\u5411\u6027\uff0c\u65b0\u6297\u4f53\u7684\u53d1\u73b0\u5360\u636e\u7740\u6838\u5fc3\u5730\u4f4d\u3002<\/span><\/p>\n

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\u968f\u7740\u6297\u4f53\u7814\u53d1\u8def\u5f84\u7684\u6210\u719f\uff0c\u5355\u900f\u819c\u548c\u53ef\u6eb6\u86cb\u767d\u7684\u9776\u70b9\u4e00\u822c\u90fd\u80fd\u591f\u901a\u8fc7\u4f53\u5916\u57fa\u56e0\u91cd\u7ec4\u6280\u672f\u5f97\u5230\u6709\u6d3b\u6027\u6784\u8c61\u7684\u91cd\u7ec4\u86cb\u767d\uff0c\u4f7f\u7528\u91cd\u7ec4\u86cb\u767d\u8fdb\u884c\u6297\u4f53\u53d1\u73b0\uff0c\u4f53\u5916\u529f\u80fd\u8bc4\u4ef7\uff0c\u8d28\u91cf\u63a7\u5236\u548c\u4f53\u5185PK\/PD\u8840\u6837\u68c0\u6d4b\u6781\u4e3a\u666e\u904d\u548c\u4fbf\u5229\uff0c\u5177\u6709\u5e02\u573a\u4ef7\u503c\u7684\u70ed\u95e8\u9776\u70b9\u5728\u77ed\u65f6\u95f4\u5185\u5747\u6709\u5927\u91cf\u7684\u65b0\u6297\u4f53\u8fdb\u5165\u4e34\u5e8a\uff0c\u9488\u5bf9\u7279\u5b9a\u70ed\u95e8\u9776\u70b9\u7684\u65b0\u53d1\u7ade\u4e89\u6781\u4e3a\u6fc0\u70c8\u3002\u4e0e\u6b64\u76f8\u53cd\u5f53\u9776\u70b9\u86cb\u767d\u4e3a\u591a\u900f\u819c\u6216\u8005GPCR\uff08\u4e03\u900f\u819c\uff09\u65f6\u4f53\u5916\u91cd\u7ec4\u8868\u8fbe\u7684\u91cd\u7ec4\u86cb\u767d\u5f80\u5f80\u4e0d\u5177\u6709\u6d3b\u6027\uff0c\u5728\u6297\u4f53\u7814\u53d1\u7684\u5404\u4e2a\u6d41\u7a0b\u4e2d\u9776\u70b9\u86cb\u767d\u5fc5\u987b\u4ee5\u7ec6\u80de\u7684\u5f62\u5f0f\u53c2\u4e0e\u7814\u53d1\u7684\u5404\u4e2a\u6d41\u7a0b\u4e2d\u53d1\u73b0\u96be\u5ea6\u5f88\u5927\uff0c\u8fdb\u5165\u4e34\u5e8a\u5b9e\u9a8c\u7684\u4ee5\u80bf\u7624\u4e3a\u9002\u5e94\u75c7\u7684\u6297\u4f53\u9776\u70b9\uff0c\u591a\u900f\u819c\u9776\u70b9\u53ea\u5360\u4e0d\u52303%\u3002<\/span><\/p>\n


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\"\u80de\u5185\u86cb\u767d\u6297\u539f--\u751f\u7269\u5236\u54c1\u6297\u80bf\u7624\u9776\u70b9\u7684\u51b0\u5c71\u4e4b\u4e0b\"<\/p>\n


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\u751f\u7269\u5236\u54c1\u6297\u80bf\u7624\u9776\u70b9\u6297\u539f\u5206\u6790<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

2009\u5e74\u524d\u540e\u7f8e\u56fdNCI\uff08National Cancer Institute\uff09\u8fdb\u884c\u4e86\u4e00\u4e2a\u8bd5\u70b9\u9879\u76ee\uff0c\u9879\u76ee\u7684\u5185\u5bb9\u662f\u5bf9\u764c\u75c7\u6297\u539f\u8fdb\u884c\u4e86\u7f57\u5217\u548c\u8bc4\u5206\uff0c\u76ee\u7684\u662f\u4e3a\u4e86\u540e\u7eed\u764c\u75c7\u75ab\u82d7\u7684\u9879\u76ee\u8fdb\u884c\u4f18\u5148\u7ea7\u6392\u5e8f\u3002\u8bc4\u5206\u7684\u6807\u51c6\u6309\u7167\u5206\u503c\u5927\u5c0f\u5206\u522b\u4e3a\u5305\u62ec\u4e34\u5e8a\u6548\u679c\uff0c\u514d\u75ab\u539f\u6027\uff0c\u7279\u5f02\u6027\uff0c\u80bf\u7624\u76f8\u5173\u6027\uff0c\u8868\u8fbe\u6c34\u5e73\u548c\u9633\u6027\u7387\u4ee5\u53ca\u7ec6\u80de\u7684\u8868\u8fbe\u5206\u5e03\u7b49\u3002\u8bf8\u591a\u4e13\u5bb6\u5bf9\u4e8e76\u4e2a\u80bf\u7624\u6297\u539f\u8fdb\u884c\u4e86\u8bc4\u5206\u6392\u5e8f\uff0c\u572876\u4e2a\u80bf\u7624\u6297\u539f\u4e2d\u5176\u4e2d\u670942\u4e2a\u662f\u819c\u86cb\u767d\u6216\u8005\u53ef\u6eb6\u5206\u6ccc\u578b\u86cb\u767d\uff0c\u670934\u4e2a\u662f<\/strong>\u80de\u5185\u86cb\u767d\u6297\u539f\uff1b<\/strong>\u5728\u6392\u540d\u524d20\u7684\u6297\u539f\u4e2d\u80de\u5185\u86cb\u767d\u6297\u539f\u536011\u4e2a\uff0c\u819c\u86cb\u767d\u6216\u8005\u53ef\u6eb6\u5206\u6ccc\u578b\u86cb\u767d\u53609\u4e2a\uff0c<\/strong>\u53ef\u89c1\u80de\u5185\u86cb\u767d\u4f5c\u4e3a\u80bf\u7624\u9776\u70b9\u5177\u6709\u6781\u5927\u7684\u6f5c\u529b\u3002<\/span><\/section>\n


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\"\u80de\u5185\u86cb\u767d\u6297\u539f--\u751f\u7269\u5236\u54c1\u6297\u80bf\u7624\u9776\u70b9\u7684\u51b0\u5c71\u4e4b\u4e0b\"<\/p>\n

\"\u80de\u5185\u86cb\u767d\u6297\u539f--\u751f\u7269\u5236\u54c1\u6297\u80bf\u7624\u9776\u70b9\u7684\u51b0\u5c71\u4e4b\u4e0b\"<\/p>\n


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\u968f\u7740\u6700\u8fd1\u8fd9\u4e9b\u5e74\u9ad8\u901a\u91cf\u6d4b\u5e8f\u7b49\u7cbe\u51c6\u533b\u7597\u68c0\u6d4b\u5174\u8d77\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u80bf\u7624\u7279\u5f02\u6027\u6216\u8005\u4e2a\u4f53\u7279\u5f02\u6027\u7684\u7a81\u53d8\u578b\u80de\u5185\u6297\u539f\uff0c\u65b0\u751f\u6297\u539f\u88ab\u53d1\u73b0\uff0c\u80de\u5185\u86cb\u767d\u5c06\u662f\u751f\u7269\u5236\u54c1\u6297\u80bf\u7624\u9776\u70b9\u51b0\u5c71\u4e4b\u4e0b\u5177\u6709\u66f4\u591a\u6bd4\u91cd\u7684\u6297\u539f\u9776\u70b9\u3002<\/span><\/p>\n

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\u9776\u5411\u80de\u5185\u86cb\u767d\u6297\u539f\u9776\u70b9<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u5728\u751f\u7269\u836f\u7684\u524d\u6cbf\u7814\u53d1\u9886\u57df\uff0c\u9776\u5411\u80bf\u7624\u76f8\u5173\u7684\u80de\u5185\u86cb\u767d\u9010\u6e10\u8fdb\u5165\u89c6\u91ce\u3002\u7531\u4e8e\u6297\u4f53\u5206\u5b50\u91cf\u7684\u9650\u5236\uff0c\u6297\u4f53\u5206\u5b50\u5f88\u96be\u901a\u8fc7\u7ec6\u80de\u819c\u76f4\u63a5\u9776\u5411\u80de\u5185\u6297\u539f\uff0c\u9776\u5411\u80de\u5185\u6297\u539f\u7684\u5f62\u5f0f\u591a\u4e3a\u95f4\u63a5\uff0c\u901a\u8fc7\u75c5\u6bd2\u8f7d\u4f53\u5c06\u76ee\u7684\u6297\u4f53\u5bfc\u5165\u7ec6\u80de\u5185\u8868\u8fbe\uff0c\u901a\u8fc7\u7eb3\u7c73\u5fae\u7403\uff0c\u8102\u8d28\u4f53\u7b49\u5c06\u6297\u4f53\u5bfc\u5165\uff0c\u5c06\u76ee\u7684\u6297\u4f53\u878d\u5408\u591a\u80bd\u4ecb\u5bfc\u5185\u5316\u8fdb\u5165\u7b49\u591a\u79cd\u5f62\u5f0f\u3002<\/span><\/p>\n

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\u9776\u5411\u80de\u5185\u6297\u539f\u4e5f\u53ef\u4ee5\u901a\u8fc7\u5229\u7528\u7ec6\u80de\u7684\u514d\u75ab\u76d1\u89c6\u673a\u5236\u6765\u8fdb\u884c\uff0c\u4e00\u822c\u6765\u8bf4\u7ec6\u80de\u5185\u7684\u6297\u539f\u4f1a\u88ab\u80de\u5185\u7684\u4e00\u4e9b\u6c34\u89e3\u9176\u964d\u89e3\u6210\u7279\u5f02\u6027\u7684\u77ed\u80bd\uff0c\u8fd9\u4e9b\u77ed\u80bd\u4f1a\u88ab\u7ec6\u80de\u5448\u9012\uff0c\u4ee5MHC\u591a\u80bd\u590d\u5408\u7269\u7684\u5f62\u5f0f\u51fa\u73b0\u5728\u7ec6\u80de\u8868\u9762\uff0cCD8+\u7684T\u7ec6\u80de\u80fd\u591f\u901a\u8fc7TCR\u8bc6\u522b\u8fd9\u4e9b\u80bf\u7624\u6216\u8005\u75c5\u6bd2\u76f8\u5173\u7684MHC\u591a\u80bd\u590d\u5408\u7269\u5e76\u6740\u6b7b\u6076\u6027\u80bf\u7624\u7ec6\u80de\u6216\u8005\u75c5\u6bd2\u611f\u67d3\u7684\u7ec6\u80de\u3002\u627e\u5230\u80bf\u7624\u76f8\u5173\u7684MHC\u591a\u80bd\u590d\u5408\u7269\u7684\u6297\u4f53\uff08TCRm Ab\uff09\u6216\u8005TCR\u4fbf\u53ef\u4ee5\u9776\u5411\u80de\u5185\u6297\u539f\u3002\u5728\u751f\u7269\u5236\u54c1\u9886\u57df\u76ee\u524d\u5e76\u6ca1\u6709\u9488\u5bf9\u80de\u5185\u6297\u539f\u7684\u7597\u6cd5\u4e0a\u5e02\uff0c\u9776\u5411\u80de\u5185\u6297\u539f\u662f\u5c06\u4f1a\u662f\u6297\u80bf\u7624\u7597\u6cd5\u7684\u4e0b\u4e00\u4e2a\u5904\u5973\u5730\u3002<\/span><\/p>\n

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\"\u80de\u5185\u86cb\u767d\u6297\u539f--\u751f\u7269\u5236\u54c1\u6297\u80bf\u7624\u9776\u70b9\u7684\u51b0\u5c71\u4e4b\u4e0b\"<\/p>\n

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\u80de\u5185\u86cb\u767d\u6c34\u89e3\u7684\u7279\u5f02\u6027\u591a\u80bd\u548cMHC I\u7ec4\u5408\u5f62\u6210MHC I\u591a\u80bd\u590d\u5408\u7269\uff0c\u5229\u7528\u8be5\u590d\u5408\u7269\u8fdb\u884c\u6297\u4f53\uff08TCRm Ab\uff09\u6216\u8005\u9ad8\u4eb2\u548c\u529b\u7684TCR\u7684\u53d1\u73b0\u5728\u6587\u732e\u4e2d\u591a\u6709\u8bb0\u8f7d\u3002<\/span><\/p>\n


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\u5728\u7814\u9776\u5411MHC I\u591a\u80bd\u590d\u5408\u7269\u751f\u7269\u5236\u54c1\u7ba1\u7ebf\u5206\u6790<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u5728\u4ee5MHC I\u591a\u80bd\u590d\u5408\u7269\u7684\u5f62\u5f0f\u9776\u5411\u80de\u5185\u86cb\u767d\u6297\u539f\u7684\u751f\u7269\u6280\u672f\u516c\u53f8\u4e2d\u4ee5Adaptimmune\/ Immunecore\u7684TCR-T\u7ec6\u80de\u7597\u6cd5\u548cEureka\u7684CAR-T\u7ec6\u80de\u7597\u6cd5\u4e3a\u4ee3\u8868\u3002<\/span><\/p>\n

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Adaptimmune\/Immunecore\u662f\u59d0\u59b9\u516c\u53f8\uff0c2008-2014\u5e74\u671f\u95f4\u5176CEO\u662f\u540c\u4e00\u4eba\uff0c\u4e24\u5bb6\u516c\u53f8\u7684\u4e13\u5229\u4e5f\u5927\u591a\u5728\u4e00\u5757\uff0c\u4e24\u5bb6\u516c\u53f8\u548cGSK, Genentech, Eli Lily\u7b49\u5927\u578b\u836f\u4f01\u90fd\u5efa\u7acb\u4e86\u7ec6\u80de\u6cbb\u7597\u76f8\u5173\u7684\u5408\u4f5c\u534f\u8bae\uff0c\u4e24\u5bb6\u516c\u53f8\u4ee5MHC I\u591a\u80bd\u590d\u5408\u7269\u4e3a\u9776\u70b9\uff0c\u5229\u7528\u5176\u5c55\u793a\u5e73\u53f0SPEAR\u7b5b\u9009\u51fa\u9ad8\u4eb2\u548c\u529b\u7684\u7a81\u53d8\u578bTCR\u3002<\/span><\/p>\n

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    \u4ea7\u54c1\u7279\u70b9<\/span><\/strong><\/p>\n<\/li>\n<\/ul>\n

    \"\u80de\u5185\u86cb\u767d\u6297\u539f--\u751f\u7269\u5236\u54c1\u6297\u80bf\u7624\u9776\u70b9\u7684\u51b0\u5c71\u4e4b\u4e0b\"<\/p>\n


    <\/p>\n

      \n
    • \n

      \u4ea7\u54c1\u76ee\u5f55<\/span><\/strong><\/p>\n<\/li>\n<\/ul>\n

      \"\u80de\u5185\u86cb\u767d\u6297\u539f--\u751f\u7269\u5236\u54c1\u6297\u80bf\u7624\u9776\u70b9\u7684\u51b0\u5c71\u4e4b\u4e0b\"<\/p>\n


      <\/p>\n

      \u5176\u4ed6\u4e9a\u578b\u548c\u9776\u70b9\u53ef\u63a5\u53d7\u5b9a\u5236\uff0c\u6837\u54c1\u514d\u8d39\u8bd5\u7528\uff0c\u6b22\u8fce\u8054\u7cfb<\/span><\/strong><\/p>\n

      \u6709\u610f\u8005\u8bf7\u8054\u7cfb:<\/span><\/p>\n

      jia.cui@kactusbio.com<\/span><\/p>\n

      400-614-0008<\/span><\/p>\n

      \u4e0a\u6d77\u5730\u533a\uff1a15021367472<\/span><\/p>\n

      \u6c5f\u82cf\u5730\u533a\uff1a17826834427<\/span><\/p>\n

      \u5176\u4ed6\u5730\u533a\uff1a18918939186<\/span><\/p>\n

      \u607a\u4f67\u751f\u7269\u79d1\u6280\uff08\u4e0a\u6d77\uff09\u6709\u9650\u516c\u53f8<\/span><\/p>\n

      \u4e0a\u6d77\u5e02\u6d66\u4e1c\u65b0\u533a\u5f20\u6c5f\u8def1238\u5f04\u6052\u8d8a\u56fd\u9645\u5927\u53a61\u53f7\u697c2C<\/span><\/p>\n


      <\/p>\n

      \u5173\u4e8e\u607a\u4f67\u751f\u7269\uff08Kactus Biosystems\uff09<\/span><\/p>\n

      \n

      \u607a\u4f67\u751f\u7269(KactusBiosystems)\u662f\u4e00\u5bb6\u4ee5\u7814\u53d1\u4e3a\u9a71\u52a8\u7684\u521b\u65b0\u578b\u86cb\u767d\u6297\u4f53\u56fd\u9645\u5316\u751f\u7269\u9ad8\u79d1\u6280\u516c\u53f8\uff0c\u4e3b\u8981\u4e13\u6ce8\u4e8e\u514d\u75ab\u6cbb\u7597\u548c\u8bca\u65ad\u5e02\u573a\u3002\u607a\u4f67\u751f\u7269\u805a\u7126\u4e8e\u5168\u7403\u521b\u65b0\u53d1\u4f01\u4e1a\u5ba2\u6237\uff0c\u63d0\u4f9b\u57fa\u4e8e\u7ed3\u6784\u8bbe\u8ba1\u7684\u529f\u80fd\u9776\u70b9\u86cb\u767d\u7279\u522b\u662f\u819c\u86cb\u767d\u7c7bCRO\u670d\u52a1\u548c\u76ee\u5f55\u4ea7\u54c1\u3002\u607a\u4f67\u751f\u7269\u4e3b\u8981\u521b\u59cb\u56e2\u961f\u6765\u81ea\u4e8e\u4e16\u754c\u4e00\u6d41\u7684\u4f01\u4e1a\u548c\u7814\u7a76\u673a\u6784\u5e76\u6709\u591a\u5e74\u751f\u7269\u533b\u836f\u884c\u4e1a\u7ecf\u9a8c\u7684\u79d1\u5b66\u5bb6\u548c\u5546\u4e1a\u7ba1\u7406\u4eba\u58eb\u3002 <\/span><\/p>\n<\/blockquote>\n


      <\/p>\n

      \u53c2\u8003\u8d44\u6599\uff1a<\/span><\/strong><\/p>\n

      1.Yixiang Xu ,Georgina To\u2019a Salazar, Ningyan Zhang, Zhiqiang An. T-cell receptor mimic (TCRm)antibody therapeutics against intracellular proteins[J]. Antibody Therapeutics,Volume 2, Issue 1, 1 January 2019, Pages 1\u201311.<\/span><\/p>\n

      2.Strohl, William R .Current progress in innovative engineered antibodies[J]. Protein & ,2017.<\/span><\/p>\n

      3.Iva T , Demin L ,Banham A H . Therapeutic Antibodies against Intracellular Tumor Antigens[J].Frontiers in Immunology, 2017, 8:<\/span>1001-.<\/span><\/p>\n

      4.Cheever M A ,Allison J P , Ferris A S , et al. The Prioritization of Cancer Antigens:<\/span> ANational Cancer Institute Pilot Project for the Acceleration of TranslationalResearch[J]. Clinical Cancer Research, 2009, 15(17):<\/span>5323-5337.<\/span><\/p>\n

      5.Dao T , Pankov D ,Scott A , et al. Therapeutic bispecific T-cell engager antibody targeting theintracellular oncoprotein WT1[J]. Nature Biotechnology, 2015.<\/span><\/p>\n


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      \u533b\u836f\u5927\u6570\u636e|\u884c\u4e1a\u52a8\u6001|\u653f\u7b56\u89e3\u8bfb<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

      \u70b9\u51fb\u4e0a\u65b9\u7684  \u25b2 \u6dfb\u52a0\u5173\u6ce8 \u751f\u7269\u5236\u54c1\u6297\u80bf\u7624\u9776\u70b9\u6297\u539f\u5206\u6790 \u9776\u5411\u6cbb\u7597\u662f\u751f\u7269\u5236\u54c1\u5728\u6297\u80bf […]<\/p>\n","protected":false},"author":1,"featured_media":83544,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/83543"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=83543"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/83543\/revisions"}],"predecessor-version":[{"id":83553,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/83543\/revisions\/83553"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/83544"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=83543"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=83543"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=83543"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}