{"id":83841,"date":"2019-04-15T00:00:50","date_gmt":"2019-04-17T03:07:48","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/83841\/"},"modified":"2019-04-17T11:07:52","modified_gmt":"2019-04-17T03:07:52","slug":"3d714c6649","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/83841\/","title":{"rendered":"\u79d1\u777f\u552f\u5b89\u300a\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u9884\u6d4b\u300b2019\u5e74\u5ea6\u62a5\u544a\u5168\u6587\uff08\u4e0a\uff09"},"content":{"rendered":"
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\u672c\u6587\u6765\u6e90\uff1a\u79d1\u777f\u552f\u5b89 \/ \u4e2d\u6587\u7ffb\u8bd1\uff1a\u9a6c\u4e50\u4f1f\uff1b<\/span>\u8f6c\u8f7d\u5df2\u83b7\u6388\u6743\u3002<\/span><\/p>\n


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\u9884\u8ba12019\u5e74\u8fdb\u5165\u5e02\u573a\u5e76\u57282023\u5e74\u6210\u4e3a\u201c\u91cd\u78c5\u70b8\u5f39\u201d\u7684\u836f\u7269\u67097\u4e2a\u3002<\/span>\u8fd9\u4e9b\u4ea7\u54c1\u4e3b\u8981\u96c6\u4e2d\u5728\u201c\u514d\u75ab\u201d\u4ee5\u53ca\u201c\u9057\u4f20\u75be\u75c5\u201d\u4e24\u4e2a\u75be\u75c5\u9886\u57df\u3002<\/span>\u4e14\u5927\u90fd\u83b7\u5f97\u4e86\u201c\u5b64\u513f\u836f\u8d44\u683c\u201d\u548c\u201c\u7a81\u7834\u6027\u6cbb\u7597\u5730\u4f4d\u201d\u3002<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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\u81ea2013\u5e74\u4ee5\u6765\uff0c\u79d1\u777f\u552f\u5b89\u7684Cortellis\u56e2\u961f\u6bcf\u5e74\u90fd\u4f1a\u9884\u6d4b\u5e74\u5ea6\u201c\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u201d\uff0c\u5b83\u4eec\u4e0a\u5e02\u540e5\u5e74\u5185\u7684\u9500\u552e\u989d\u8fbe\u5230\u91cd\u78c5\u70b8\u5f39\u7ea7\u522b\uff08\u5373\u8fbe\u5230\u6216\u8d85\u8fc710\u4ebf\u7f8e\u5143\uff09\u3002<\/span><\/p>\n


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\u4eca\u5e74\u7684\u8fd9\u4efd\u62a5\u544a\u4e2d\uff0c\u6211\u4eec\u9884\u6d4b\u4e867\u79cd\u53ef\u80fd\u57282019\u5e74\u4e0a\u5e02\u7684\u65b0\u836f\uff0c\u8fd97\u6b3e\u65b0\u836f\u57285\u5e74\u5185\u7684\u9500\u552e\u989d\u90fd\u5c06\u8fbe\u5230\u91cd\u78c5\u70b8\u5f39\u7ea7\u522b\u3002<\/span><\/p>\n


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\u8be5\u62a5\u544a\u5229\u7528Cortellis\u63d0\u4f9b\u7684\u4e00\u7cfb\u5217\u4fe1\u606f\u8fdb\u884c\u9884\u6d4b\u3002\u4eca\u5e74\u7684\u62a5\u544a\u8fd8\u91c7\u7528\u4e86Cortellis\u65b0\u589e\u7684\u836f\u7269\u4e0a\u5e02\u65f6\u95f4\u53ca\u6210\u529f\u7387\u7684\u9884\u6d4b\u6a21\u5757\u3002<\/span><\/p>\n


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\u672c\u62a5\u544a\u5c06\u91cd\u70b9\u4ecb\u7ecd\u8fd97\u79cd\u836f\u7269\uff0c\u5305\u62ec\u4ed6\u4eec\u6240\u5728\u9886\u57df\u7684\u53d1\u75c5\u7387\u3001\u836f\u7269\u4f5c\u7528\u673a\u5236\u3001\u9500\u552e\u9884\u6d4b\u4ee5\u53ca\u4e0a\u5e02\u540e\u5c06\u8981\u9762\u4e34\u7684\u5e02\u573a\u7ade\u4e89\u683c\u5c40\u3002<\/span><\/p>\n


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\u8fd97\u79cd\u65b0\u836f\uff0c\u6709\u4e00\u4e9b\u5171\u540c\u70b9\uff0c\u6982\u51b5\u8d77\u6765\u5171\u67093\u4e2a\uff1a<\/span><\/p>\n


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\u9996\u5148\u662f\u591a\u6837\u5316\u7684\u7ade\u4e89\u3002\u6211\u4eec\u9884\u6d4b\u7684\u8fd97\u4e2a\u836f\u7269\uff0c\u4e0a\u5e02\u540e\u5c06\u9762\u4e34\u591a\u65b9\u9762\u7684\u7ade\u4e89\u3002\u8be5\u62a5\u544a\u5c06\u9488\u5bf9\u5404\u4e2a\u9886\u57df\u7684\u7ade\u4e89\u683c\u5c40\u8fdb\u884c\u9610\u8ff0\u3002<\/span><\/p>\n


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\u5176\u6b21\u662f\u75be\u75c5\u9886\u57df\u9ad8\u5ea6\u96c6\u4e2d\u3002\u8fd97\u4e2a\u836f\u7269\u7684\u6cbb\u7597\u9886\u57df\u51e0\u4e4e\u5168\u90e8\u96c6\u4e2d\u5728\u201c\u9057\u4f20\u75be\u75c5\u201d\u548c\u201c\u8fc7\u5ea6\u514d\u75ab\u53cd\u5e94(\u5305\u62ec\u81ea\u8eab\u514d\u75ab) \u201d\u4e3a\u7279\u5f81\u7684\u75be\u75c5\u9886\u57df\u3002\u80fd\u591f\u6e05\u6670\u5730\u9610\u660e\u8fd9\u4e9b\u75be\u75c5\u7684\u53d1\u75c5\u673a\u7406\uff0c\u5e76\u6709\u7684\u653e\u77e2\u5730\u8bbe\u8ba1\u5e76\u6210\u529f\u5f00\u53d1\u51fa\u6709\u6cbb\u7597\u4ef7\u503c\u7684\u836f\u7269\uff0c\u4ece\u4fa7\u9762\u8bc1\u660e\u4e86\u8fd1\u51e0\u5341\u5e74\u6765\u751f\u547d\u79d1\u5b66\u7684\u5de8\u5927\u8fdb\u6b65\u3002<\/span><\/p>\n


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\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u4eca\u5e74\u9884\u6d4b\u76847\u79cd\u836f\u7269\u4e2d\u6ca1\u6709\u6297\u80bf\u7624\u836f\u3002\u4f46\u8fd9\u5e76\u4e0d\u8bc1\u660e\u80bf\u7624\u836f\u7684\u7814\u53d1\u70ed\u5ea6\u4e0b\u964d\uff0c\u76f8\u53cd\uff1a<\/span><\/p>\n

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    \u8fd9\u4e00\u73b0\u8c61\u53cd\u6620\u4e86\u65b0\u80bf\u7624\u5b66\u6cbb\u7597\u8303\u56f4\u7684\u4e0d\u65ad\u589e\u52a0\uff08\u610f\u5473\u7740\u7ec6\u5206\u5e02\u573a\u589e\u52a0\uff09\uff0c\u7ec6\u5206\u5e02\u573a\u7684\u589e\u52a0\u5c06\u5bfc\u81f4\u6bcf\u4e00\u4e2a\u7ec6\u5206\u9886\u57df\u6f5c\u5728\u5e02\u573a\u4efd\u989d\u7684\u51cf\u5c11\uff0c\u4ece\u800c\u964d\u4f4e\u4e86\u8fd9\u4e9b\u836f\u7269\u6210\u4e3a\u91cd\u78c5\u70b8\u5f39\u7684\u53ef\u80fd\u6027\u3002<\/span><\/p>\n<\/li>\n

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    \u8fd9\u4e00\u73b0\u8c61\u4e5f\u53cd\u6620\u4e86\u6297\u80bf\u7624\u836f\u65b0\u9002\u5e94\u75c7\u7684\u6269\u5927\uff0c\u8fd9\u4e9b\u836f\u7269\u5927\u90fd\u65e9\u5df2\u4e0a\u5e02\uff0c\u800c\u8fd9\u7c7b\u836f\u7269\u4e0d\u5728\u672c\u62a5\u544a\u5206\u6790\u7684\u7eb3\u5165\u8303\u56f4\u3002<\/span><\/p>\n<\/li>\n<\/ul>\n


    <\/p>\n

    \u7b2c\u4e09\u662f\u540c\u8d28\u5316\u836f\u7269\u4e0e\u5229\u57fa\u836f\u7269\u7684\u9c9c\u660e\u5bf9\u6bd4\u3002\u4e0e\u7ade\u4e89\u6fc0\u70c8\u7684\u5feb\u901f\u8ddf\u8fdb\u7684\u836f\u7269\u5f00\u53d1\u6a21\u5f0f\u76f8\u6bd4\uff08Fast-Follow\uff09\uff0c\u5229\u57fa\u836f\u7269\u7684\u5f00\u53d1\u5438\u5f15\u4e86\u66f4\u591a\u7684\u6295\u8d44\u3002\u8fd9\u7c7b\u836f\u7269\u7684\u7a81\u7834\u70b9\u4e3b\u8981\u96c6\u4e2d\u5728\u201c\u7f55\u7528\u836f\u201d\u3001\u201c\u672a\u6ee1\u8db3\u7684\u4e34\u5e8a\u9700\u6c42\u201d\u3001\u201c\u5b89\u5168\u6027\u3001\u6709\u6548\u6027\u3001\u987a\u5e94\u6027\u5b58\u5728\u7f3a\u9677\u201d \u7b49\u65b9\u9762\u3002\u4eca\u5e74\u9884\u6d4b\u76847\u79cd\u836f\u7269\u4e2d\u6709\u5f88\u5927\u4e00\u90e8\u5206\u662f\u5229\u57fa\u836f\u7269\uff0c\u4e14\u8fd9\u4e9b\u836f\u7269\u4e2d\uff0c\u5927\u90fd\u83b7\u5f97\u4e86\u4f18\u5148\u5ba1\u8bc4\u3001\u7a81\u7834\u6027\u7597\u6cd5\u6216\u5feb\u901f\u901a\u9053\u7b49\u5ba1\u8bc4\u8ba4\u5b9a\uff0c\u5177\u4f53\u6570\u91cf\u7edf\u8ba1\u5982\u4e0b \uff1a<\/span><\/p>\n

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      \u83b7\u5b64\u513f\u836f\u8d44\u683c\uff1a\u7f8e\u56fd9\u4e2a\u3001\u6b27\u6d324\u4e2a\u3001\u65e5\u672c1\u4e2a\u3002<\/span><\/p>\n<\/li>\n

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      \u7a81\u7834\u6027\u6cbb\u7597\u8d44\u683c\uff1a\u7f8e\u56fd4\u4e2a<\/span><\/p>\n<\/li>\n

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      \u4f18\u5148\u836f\u54c1\u8d44\u683c\uff1a\u6b27\u6d322\u4e2a<\/span><\/p>\n<\/li>\n

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      \u518d\u751f\u533b\u5b66\u5148\u8fdb\u7597\u6cd5\u8d44\u683c\uff1a\u7f8e\u56fd1\u4e2a<\/span><\/p>\n<\/li>\n

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      \u65e5\u672c1\u4e2aSakigake\u8d44\u683c<\/span><\/p>\n<\/li>\n<\/ul>\n


      <\/p>\n<\/section>\n<\/section>\n<\/section>\n

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         3<\/span><\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/td>\n

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      \u6cbb\u7597\uff08\u6839\u636e\u75be\u75c5\u9886\u57df\u53ca\u6ce8\u518c\u5ba1\u8bc4\u8d44\u683c\uff09<\/span><\/strong><\/p>\n<\/section>\n

      <\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/section>\n<\/section>\n<\/section>\n
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      1\uff09\u9057\u4f20\u75be\u75c5<\/span><\/p>\n

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        Zolgensma: \u8be5\u836f\u4e3a\u810a\u9ad3\u6027\u808c\u840e\u7f29\u9057\u4f20\u7f3a\u9677\u7684\u57fa\u56e0\u6cbb\u7597\u836f\u7269\u30022016\u5e74\uff0c\u8be5\u9886\u57df\u7684First-in-Class\u836f\u7269Spinraza\u5728\u7f8e\u56fd\u4e0a\u5e02\uff0c2017\u5e74\u5728\u6b27\u76df\u4e0a\u5e02\uff0c\u8be5\u836f\u66fe\u83b7\u5b64\u513f\u836f\u7269\u4e0e\u7a81\u7834\u7597\u6cd5\u8d44\u683c\u3002Zolgensma\u4e0a\u5e02\u540e\u5c06\u9762\u4e34Spinraza\u7684\u6fc0\u70c8\u7ade\u4e89\u3002<\/span><\/p>\n


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      • \n

        LentiGlobin:\u8be5\u836f\u4e3a\u03b2\u5730\u4e2d\u6d77\u8d2b\u8840\u7f3a\u9677\uff08\u4e00\u79cd\u5bfc\u81f4\u5371\u53ca\u751f\u547d\u7684\u8d2b\u8840\u7684\u8840\u6db2\u7d0a\u4e71\uff09\u7684\u57fa\u56e0\u6cbb\u7597\u836f\u7269\uff0c\u66fe\u83b7\u5b64\u513f\u836f\u548c\u7a81\u7834\u6027\u6cbb\u7597\u8d44\u683c\u3002\u5e02\u573a\u4e0a\u552f\u4e00\u76f4\u63a5\u7684\u7ade\u4e89\u662f\u79fb\u690d\uff0c\u4f46\u540e\u8005\u56e0\u4e3a\u5f02\u4f53\u57fa\u56e0\u7684\u95ee\u9898\uff0c\u98ce\u9669\u5de8\u5927\u3002<\/span><\/p>\n


        <\/p>\n<\/li>\n<\/ul>\n

        2\uff09\u9057\u4f20\u75be\u75c5\u4e0e\u514d\u75ab\u8fc7\u5ea6\u5e94\u7b54\/\u81ea\u8eab\u514d\u75ab<\/span><\/p>\n

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        • \n

          Ultomiris: \u8be5\u836f\u662f\u4e00\u79cd\u6cbb\u7597\u9635\u53d1\u6027\u7761\u7720\u6027\u8840\u7ea2\u86cb\u767d\u5c3f\u75c7\uff08\u4e00\u79cd\u7f55\u89c1\u7684\u3001\u53ef\u80fd\u81f4\u547d\u7684\u8840\u6db2\u75be\u75c5\uff09\u7684\u836f\u7269\u30022018\u5e7412\u6708\u83b7FDA\u6279\u51c6\uff0c\u66fe\u83b7\u201c\u5b64\u513f\u836f\u7269\u8d44\u683c\u201d\u3002\u8be5\u836f\u662fAlexion\u91cd\u78c5\u70b8\u5f39\u4ea7\u54c1Soliris\u7684\u4e0b\u4e00\u4ee3\u4ea7\u54c1\uff0c\u6709\u6548\u6027\u65b9\u9762\u975e\u52a3\u6548\u4e8eSoliris\uff0c\u4f46\u987a\u5e94\u6027\u6709\u4e86\u5f88\u5927\u63d0\u5347\uff0c\u5e02\u573a\u6f5c\u529b\u5de8\u5927\u3002<\/span><\/p>\n


          <\/p>\n<\/li>\n<\/ul>\n

          3\uff09\u514d\u75ab\u8fc7\u5ea6\u5e94\u7b54\/\u81ea\u8eab\u514d\u75ab<\/span><\/p>\n

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          • \n

            Upadacitinib\uff1a\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u6cbb\u7597\u836f\u7269\u3002\u4e0a\u5e02\u540e\u5c06\u9762\u4e34\u54c1\u724c\u836fHumira\u3001Enbrel\u3001Simponi\u3001Remicade\u548cCimzia\u7684\u6fc0\u70c8\u7ade\u4e89\uff0c\u9664\u6b64\u4e4b\u5916\uff0cHumira\u548cEnbrel\u7684\u751f\u7269\u7c7b\u4f3c\u7269\u4e5f\u5c06\u8fdb\u4e00\u6b65\u589e\u52a0\u8be5\u9886\u57df\u7684\u7ade\u4e89\u7a0b\u5ea6\u3002<\/span><\/p>\n<\/li>\n

          • \n

            Risankizumab:\u94f6\u5c51\u75c5\u6cbb\u7597\u836f\u7269\u3002\u5b83\u5c06\u9762\u4e34\u591a\u79cd\u6cbb\u7597\u624b\u6bb5\u7684\u7ade\u4e89 \uff0c\u5982\uff1a\u5c40\u90e8\u7528\u836f\u3001\u5149\u7597\u6cd5\u3001\u7cfb\u7edf\u6027\u836f\u7269\u6cbb\u7597\u3002<\/span><\/p>\n<\/li>\n

          • \n

            AR-101:\u82b1\u751f\u8fc7\u654f\u6cbb\u7597\u836f\u3002\u8be5\u9886\u57df\u7684First-in-Class\u836f\u7269\uff0c\u66fe\u83b7\u7a81\u7834\u6027\u6cbb\u7597\u8d44\u683c\u3002\u9884\u8ba1\u4e0a\u5e02\u540e\u4e00\u6bb5\u65f6\u95f4\u5185\u4e0d\u4f1a\u9762\u4e34\u5176\u4ed6\u836f\u7269\u7684\u7ade\u4e89\u538b\u529b\u3002<\/span><\/p>\n


            <\/p>\n<\/li>\n<\/ul>\n

            4\uff09\u6162\u6027\u5e76\u53d1\u75c7<\/span><\/p>\n

              \n
            • \n

              Roxadustat\uff1a\u6162\u6027\u80be\u75c5\u8d2b\u8840\u7684\u6cbb\u7597\u836f\u7269\u3002\u957f\u671f\u7ade\u4e89\u5bf9\u624b\u6709\u8f83\u9ad8\u7684\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u548c\u81f4\u764c\u98ce\u9669\uff0c\u4e3a\u8be5\u836f\u7684\u201c\u5f02\u519b\u7a81\u8d77\u201d\u63d0\u4f9b\u4e86\u673a\u4f1a\u3002<\/span><\/p>\n<\/li>\n<\/ul>\n


              <\/p>\n<\/section>\n<\/section>\n<\/section>\n

              \n
              \n
              \n

              \u5c06\u57282019\u5e74\u8fdb\u5165\u5e02\u573a\u5e76\u57282023\u5e74<\/strong><\/span><\/p>\n

              \u6210\u4e3a\u201c\u91cd\u78c5\u70b8\u5f39\u201d\u76847\u4e2a\u836f\u7269<\/strong><\/span><\/strong><\/span><\/p>\n

              \n
              \n
              \n

              \u79d1\u777f\u552f\u5b89<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

              \n
              \n
              \"\u79d1\u777f\u552f\u5b89\u300a\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u9884\u6d4b\u300b2019\u5e74\u5ea6\u62a5\u544a\u5168\u6587\uff08\u4e0a\uff09\"<\/section>\n<\/section>\n<\/section>\n

              <\/span>
              <\/p>\n<\/section>\n<\/section>\n<\/section>\n

              \n
              \n
              \n

              7\u4e2a\u836f\u7269\u5728\u4e0d\u540c\u56fd\u5bb6\u548c\u5730\u533a\u7684\u4f18\u5148\u5ba1\u8bc4\u9014\u5f84<\/strong><\/span><\/p>\n

              \u79d1\u777f\u552f\u5b89<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

              \n
              \n
              \"\u79d1\u777f\u552f\u5b89\u300a\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u9884\u6d4b\u300b2019\u5e74\u5ea6\u62a5\u544a\u5168\u6587\uff08\u4e0a\uff09\"<\/section>\n<\/section>\n<\/section>\n
              \n
              \n
              \n


              <\/p>\n<\/section>\n<\/section>\n<\/section>\n

              \n
              \n
              \n
              <\/section>\n
              \n

              \u65b9 \u6cd5<\/strong><\/span><\/p>\n<\/section>\n

              <\/section>\n<\/section>\n
              <\/section>\n<\/section>\n<\/section>\n
              \n
              \n
              \n

              \u8be5\u62a5\u544a\u7684\u6570\u636e\u6e90\u4e8e\u79d1\u777f\u552f\u5b89\u7684Cortellis\u6570\u636e\u5e93\uff0c\u8be5\u6570\u636e\u5e93\u662f\u751f\u547d\u79d1\u5b66\u7ade\u4e89\u3001\u4e34\u5e8a\u3001\u5ba1\u8bc4\u60c5\u62a5\u548c\u5206\u6790\u7684\u4e3b\u8981\u6765\u6e90\uff0c\u5168\u9762\u6536\u5f55\u4e86\u5e74\u5ea6\u62a5\u544a\u3001\u7814\u53d1\u7ba1\u7ebf\u3001\u4e34\u5e8a\u8bd5\u9a8c\u3001\u4e13\u5229\u4fe1\u606f\u3001\u5316\u5b66\u8d44\u6599\u3001\u516c\u53f8\u516c\u544a\u3001\u5e76\u8d2d\u4ea4\u6613\u548c\u4f1a\u8bae\u62a5\u544a\u7b49\u8d44\u8baf\u4fe1\u606f\u3002<\/span><\/p>\n


              <\/p>\n

              \u901a\u8fc7\u6570\u636e\u5e93\u7684\u9ad8\u7ea7\u68c0\u7d22\u529f\u80fd\uff0c\u6211\u4eec\u7b5b\u9009\u51fa\u5904\u4e8e\u4e34\u5e8aII\u671f \u3001III\u671f\u3001\u6ce8\u518c\u524d\u671f\u3001\u6ce8\u518c\u671f\u62162019\u5e74\u521d\u4e0a\u5e02\u7684\u65b0\u836f\uff0c\u7136\u540e\u4ece\u68c0\u7d22\u7ed3\u679c\u4e2d\u6ee4\u6389\u90a3\u4e9b\u8fd8\u5904\u4e8e\u5f00\u53d1\u4f462019\u5e74\u4e4b\u524d\u5c31\u5df2\u7ecf\u4e0a\u5e02\u7684\u836f\u7269\uff0c\u5728\u6b64\u57fa\u7840\u4e0a\u518d\u8fdb\u884c\u6570\u636e\u7684\u7b5b\u9009\u548c\u8fc7\u6ee4\uff0c\u83b7\u5f97\u4e86\u57282023\u5e74\u9884\u671f\u9500\u552e\u989d\u8d85\u8fc710\u4ebf\u7f8e\u91d1\u7684\u836f\u7269\u6e05\u5355\uff0c\u6700\u540e\u6211\u4eec\u518d\u5bf9\u836f\u54c1\u5f00\u53d1\u516c\u53f8\u516c\u5e03\u7684\u9884\u671f\u83b7\u6279\u548c\u4e0a\u5e02\u65f6\u95f4\uff0c\u5e76\u7efc\u5408\u5176\u4ed6\u56e0\u7d20\u8fdb\u884c\u9010\u4e2a\u4eba\u5de5\u5206\u6790\uff0c\u786e\u5b9a\u4e86\u6709\u671b\u57282019\u5e74\u4e0a\u5e02\u7684\u65b0\u836f\u3002<\/span><\/p>\n


              <\/p>\n

              \u901a\u8fc7\u4eba\u5de5\u7b5b\u67e5\uff0c\u6211\u4eec\u83b7\u5f97\u4e867\u4e2a\u201c2019\u5e74\u6700\u503c\u5f97\u5173\u6ce8\u7684\u65b0\u836f\u201d\uff0c\u7136\u540e\u518d\u5bf9\u6bcf\u4e2a\u836f\u7269\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3001\u5ba1\u8bc4\u72b6\u6001\u3001\u4e0a\u5e02\u60c5\u51b5\uff08\u5305\u62ec\u7ade\u4e89\u4ea7\u54c1\uff09\u548c\u5ba1\u8bc4\u8ba4\u5b9a\uff08\u5982\u5b64\u513f\u836f\u3001\u4f18\u5148\u5ba1\u8bc4\u7b49\uff09\u8fdb\u884c\u7814\u7a76\u4e0e\u5206\u6790\u3002\u53c2\u8003\u6570\u636e\u6765\u6e90\u5305\u62ecCortellis\u4e13\u5bb6\u7684SWOT\u5206\u6790\u3001\u5236\u836f\u516c\u53f8\u53d1\u5e03\u7684\u65b0\u95fb\u3001\u516c\u5f00\u7684\u540c\u884c\u8bc4\u8bae\u3001\u7ade\u4e89\u5bf9\u624b\u7684\u9500\u552e\u6570\u636e\u3001\u5e74\u62a5\u7b49\u5176\u4ed6\u516c\u5f00\u4fe1\u606f\uff08\u901a\u8fc7Cortellis\u6570\u636e\u5e93\u83b7\u5f97\uff09\u3002<\/span><\/p>\n


              <\/p>\n

              \u4eca\u5e74\uff0c\u8be5\u56e2\u961f\u8fd8\u5229\u7528\u4e86\u79d1\u777f\u552f\u5b89\u72ec\u7279\u7684\u9884\u6d4b\u6a21\u578b\uff0c\u4ee5\u671f\u63d0\u9ad8\u836f\u7269\u4e0a\u5e02\u65f6\u95f4\u548c\u6210\u529f\u7387\u7684\u9884\u6d4b\u3002\u8be5\u9884\u6d4b\u6a21\u578b\u5e94\u7528\u7edf\u8ba1\u5efa\u6a21\u548c\u673a\u5668\u5b66\u4e60\u7684\u65b9\u5f0f\uff0c\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u63d0\u9ad8\u4e86\u7814\u53d1\u7ba1\u7ebf\u9884\u6d4b\u7684\u51c6\u786e\u7387\uff0c\u589e\u5f3a\u4e86\u7814\u53d1\u6295\u8d44\u51b3\u7b56\u7684\u4fe1\u5fc3\u3002<\/span><\/p>\n


              <\/span><\/p>\n

              \n
              \n
              \n
              \n
              \n
              <\/section>\n<\/section>\n
              \n
              <\/section>\n<\/section>\n
              <\/section>\n<\/section>\n
              \n
              \n

              2019\u5e74\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u4ecb\u7ecd<\/strong><\/p>\n<\/section>\n<\/section>\n

              \n
              \n
              <\/section>\n<\/section>\n
              \n
              <\/section>\n<\/section>\n
              <\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


              <\/p>\n<\/section>\n<\/section>\n<\/section>\n

              \n
              \n
              \n
              \n
              \n
              \n
              \n
              \n
              \n
              \n

              1. \u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u7684\u65b0\u836f\uff1aUpadacitinib<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

              \n
              \n
              \n


              <\/p>\n<\/section>\n<\/section>\n<\/section>\n

              \n
              \n
              \n

              \u4e0a\u5e02\u540e\u5c06\u9762\u4e34\u54c1\u724c\u836fHumira\u3001Enbrel\u3001 Simponi\u3001 Remicade\u548cCimzia\u7684\u6fc0\u70c8\u7ade\u4e89\uff0c\u9664\u6b64\u4e4b\u5916\uff0cHumira\u548cEnbrel\u7684\u751f\u7269\u7c7b\u4f3c\u7269\u4e5f\u5c06\u8fdb\u4e00\u6b65\u589e\u52a0\u8be5\u9886\u57df\u7684\u7ade\u4e89\u7a0b\u5ea6\u3002<\/span><\/p>\n


              <\/p>\n<\/section>\n<\/section>\n<\/section>\n

              \n
              \n
              \n

              \u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u662f\u4e00\u79cd\u6162\u6027\u3001\u8fdb\u884c\u6027\u3001\u4fb5\u8680\u6027\u7684\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3002\u81ea\u8eab\u514d\u75ab\u7cfb\u7edf\u901a\u8fc7\u653b\u51fb\u5173\u8282\u6ed1\u819c\uff0c\u5bfc\u81f4\u75bc\u75db\u3001\u80bf\u80c0\u548c\u50f5\u786c\u3002\u5fc3\u810f\u3001\u80ba\u3001\u76ae\u80a4\u3001\u773c\u775b\u3001\u80be\u810f\u548c\u8840\u7ba1\u7b49\u7ec4\u7ec7\u4e5f\u4f1a\u53d7\u5230\u635f\u5bb3\u3002\u6b64\u5916\uff0c\u5e38\u89c1\u7684\u75c7\u72b6\u8fd8\u5305\u62ec\u75b2\u52b3\u3001\u98df\u6b32\u4e0d\u632f\u548c\u4f53\u91cd\u51cf\u8f7b\u3002\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u7684\u53d1\u75c5\u539f\u56e0\u76ee\u524d\u5c1a\u4e0d\u660e\u786e\uff0c\u4e34\u5e8a\u4e0a\u4e5f\u6ca1\u6709\u6cbb\u6108\u65b9\u6cd5\u3002\u836f\u7269\u6cbb\u7597\u4e3b\u8981\u4ee5\u51cf\u8f7b\u75c7\u72b6\u548c\u63a8\u540e\u75be\u75c5\u53d1\u4f5c\u65f6\u95f4\u4e3a\u76ee\u7684\u3002\u4ece\u53d1\u75c5\u7387\u6765\u770b\uff0c\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u5f71\u54cd\u5168\u7403\u4eba\u53e3\u76840.3%\u52301%\u3002<\/span><\/p>\n


              <\/p>\n

              Upadacitinib<\/span><\/strong><\/span><\/p>\n

              Upadacitinib\u662f\u7531AbbVie\u7814\u53d1\u7684\u4e00\u79cd\u53e3\u670dJAK1\u6291\u5236\u5242\u3002JAK\u5bb6\u65cf\u5206\u5b50\u8c03\u63a7\u529f\u80fd\u7684\u7d0a\u4e71\u4e0e\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u53d1\u75c5\u673a\u5236\u4e2d\u4fc3\u708e\u4ecb\u8d28\u7684\u751f\u4ea7\u6709\u5173\uff0c\u56e0\u6b64\uff0c\u6291\u5236JAK\u86cb\u767d\u53ef\u4ee5\u6709\u6548\u5730\u63a7\u5236\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u3002<\/span><\/p>\n


              <\/p>\n

              2018\u5e7412\u6708\uff0cAbbVie\u5206\u522b\u5411\u7f8e\u56fd\u548c\u6b27\u76df\u9012\u4ea4\u4e86Upadacitinib\u7684NDA\u8d44\u6599\u3002Cortellis\u9884\u6d4b\uff0c\u8be5\u836f\u5728\u4e24\u4e2a\u5730\u533a\u83b7\u6279\u6210\u529f\u7387\u5747\u4e3a95%\uff0c\u4ece\u83b7\u6279\u65f6\u95f4\u6765\u770b\uff0c\u8be5\u836f\u5728\u7f8e\u56fd\u7684\u4e0a\u5e02\u65f6\u95f4\u4e3a2019\u5e749\u6708\uff0c\u6b27\u76df\u7684\u4e0a\u5e02\u65f6\u95f4\u4e3a2019\u5e7410\u6708\u3002\u4ece\u5e02\u573a\u9884\u6d4b\u6765\u770b\uff0c\u8be5\u836f\u52302023\u5e74\u9500\u552e\u989d\u5c06\u7a81\u783422\u4ebf\u7f8e\u91d1\u3002<\/span><\/p>\n


              <\/p>\n<\/section>\n<\/section>\n<\/section>\n

              \n
              \n
              \n

              Upadacitinib\u4e0a\u5e02\u65f6\u95f4\u53ca\u6210\u529f\u7387\u9884\u6d4b<\/span><\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

              \n
              \n
              \"\u79d1\u777f\u552f\u5b89\u300a\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u9884\u6d4b\u300b2019\u5e74\u5ea6\u62a5\u544a\u5168\u6587\uff08\u4e0a\uff09\"<\/section>\n<\/section>\n<\/section>\n
              \n
              \n
              \n

              Source: Cortellis Analytics \u2013 Drug Timeline & Success Rates<\/span><\/p>\n


              <\/p>\n<\/section>\n<\/section>\n<\/section>\n

              \n
              \n
              \n

              Upadacitinib\u6ce8\u518c\u8d44\u6599\u7684\u63d0\u4ea4\u57fa\u4e8e\u4e00\u9879III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08SELECT\u8bd5\u9a8c\uff09\u3002\u8be5\u8bd5\u9a8c\u8bc1\u5b9e\uff0c\u8be5\u836f\u5bf9\u4ee5\u4e0b\u7c7b\u578b\u7684\u60a3\u8005\u7597\u6548\u663e\u8457\uff1a<\/span><\/p>\n

                \n
              • \n

                \u5bf9\u5e38\u89c4\u6297\u98ce\u6e7f\u75c5\u836f\u7269\u53cd\u5e94\u4e0d\u5145\u5206\u7684\u60a3\u8005\uff08SELECT-NEXT\u8bd5\u9a8c\uff09<\/span><\/p>\n<\/li>\n

              • \n

                \u5bf9\u751f\u7269\u7c7b\u6297\u98ce\u6e7f\u75c5\u53cd\u5e94\u4e0d\u5145\u5206\u6216\u4e0d\u80fd\u8010\u53d7\u7684\u60a3\u8005\uff08SELECT-BEYOND\u8bd5\u9a8c\uff09<\/span><\/p>\n<\/li>\n

              • \n

                \u5728\u4f7f\u7528\u7532\u6c28\u8776\u5464\u5355\u4e00\u6cbb\u7597\u540e\u6cbb\u7597\u6548\u679c\u4e0d\u7406\u60f3\u7684\u60a3\u8005\uff08SELECT-MONOTHERAPY\u8bd5\u9a8c\uff09<\/span><\/p>\n<\/li>\n

              • \n

                \u8054\u5408\u5e94\u7528\u7532\u6c28\u8776\u5464\u6cbb\u7597\u53cd\u5e94\u4e0d\u4f73\u7684\u60a3\u8005\uff08SELECT-COMPARE\uff09<\/span><\/p>\n<\/li>\n

              • \n

                \u672a\u670d\u7528\u7532\u6c28\u8776\u5464\u7684\u60a3\u8005\uff08SELECT-EARLY\uff09<\/span><\/p>\n


                <\/p>\n<\/li>\n<\/ul>\n

                \u9002\u5e94\u75c7\u62d3\u5c55\u65b9\u9762\uff0c\u9664\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u5916\uff0cUpadacitinib\u6cbb\u7597\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u3001\u94f6\u5c51\u75c5\u5173\u8282\u708e\u3001\u514b\u7f57\u6069\u75c5\u548c\u5f02\u4f4d\u6027\u76ae\u708e\u7684III\u671f\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u4e2d\u3002\u5f3a\u76f4\u6027\u810a\u67f1\u708e\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e5f\u5df2\u7ecf\u63a8\u5230\u4e86II\u671f\uff0c\u9664\u6b64\u4e4b\u5916\uff0c\u5de8\u7ec6\u80de\u52a8\u8109\u708e\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e5f\u5df2\u8ba1\u5212\u542f\u52a8\u3002<\/span><\/p>\n


                <\/p>\n

                \u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u5e02\u573a<\/strong><\/span><\/strong><\/strong><\/span><\/p>\n

                \u5982\u679cUpadacitinib\u987a\u5229\u83b7\u6279\uff0c\u9884\u8ba1\u5c06\u57282019\u5e74\u4e0a\u5e02\u3002\u4f46\u8be5\u836f\u7269\u4e0a\u5e02\u540e\u5c06\u9762\u4e34\u540c\u7c7b\u836f\u7269\u7684\u6fc0\u70c8\u7ade\u4e89\uff08\u5c24\u5176\u751f\u7269\u836f\uff09\u3002\u800c\u4e14\u8fd9\u4e9b\u751f\u7269\u836f\u5927\u591a\u90fd\u662f\u4e34\u5e8a\u4e0a\u4f7f\u7528\u591a\u5e74\u7684\u4e34\u5e8a\u63a8\u8350\u836f\u7269\u3002<\/span><\/p>\n


                <\/p>\n

                \u751f\u7269\u836f\u4f5c\u4e3a\u8be5\u9886\u57df\u7684\u5e02\u573a\u9738\u4e3b\uff0c\u5927\u90e8\u5206\u4ea7\u54c1\u7684\u4f5c\u7528\u673a\u5236\u4e3aTNF\u6291\u5236\u5242\uff0c\u5982Humira\u3001Enbrel\u3001Simponi\u3001Remicade\u548cCimzia\u7b49\u3002\u300a\u7f8e\u56fd\u98ce\u6e7f\u75c5\u5b66\u4f1a\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u6cbb\u7597\u6307\u5357\u300b\u63a8\u8350\u8fd9\u4e9b\u836f\u7269\u4f5c\u4e3a\u6297\u98ce\u6e7f\u75c5\u7684\u4e8c\u7ebf\u6cbb\u7597\u836f\u7269\u3002\u9664\u54c1\u724c\u751f\u7269\u836f\u4e4b\u5916\uff0c\u751f\u7269\u7c7b\u4f3c\u7269\u7684\u4e0a\u5e02\u8fdb\u4e00\u6b65\u589e\u52a0\u4e86\u8be5\u9886\u57df\u7684\u7ade\u4e89\u7a0b\u5ea6\u3002\u6bd4\u5982\uff0c\u6709\u201c\u5168\u7403\u836f\u738b\u201d\u4e4b\u79f0\u7684Humira\uff082017\u5e74\u9500\u552e\u989d\u4e3a187.7\u4ebf\u7f8e\u91d1\uff09\uff0c\u5438\u5f15\u4e86\u5f88\u591a\u4eff\u5236\u836f\u516c\u53f8\u7684\u9752\u7750\uff0c\u5176\u751f\u7269\u7c7b\u4f3c\u7269\u5df2\u7ecf\u4e8e2018\u5e74\u8fdb\u5165\u6b27\u76df\u5e02\u573a\uff0c\u5e76\u5c06\u4e8e2023\u5e74\u5728\u7f8e\u56fd\u4e0a\u5e02\u3002<\/span><\/p>\n


                <\/p>\n

                \u9664TNF\u6291\u5236\u5242\u88ab\u63a8\u8350\u4f5c\u4e3a\u4e8c\u7ebf\u7528\u836f\u4e4b\u5916\uff0c\u5728\u4f7f\u7528\u6700\u65b0\u7684\u836f\u7269\u4e4b\u524d\uff0c\u201c\u975eTNF\u6291\u5236\u5242\u751f\u7269\u836f\u201d \u5728\u4e34\u5e8a\u4e0a\u4e5f\u901a\u5e38\u88ab\u63a8\u8350\u4e3a\u4e8c\u7ebf\u7528\u836f\u3002\u5982Actemra\u3001Orencia\u3001Rituxan\u7b49\uff0c\u5b83\u4eec\u7684\u4e34\u5e8a\u5b9a\u4f4d\u4e3aTNF\u751f\u7269\u836f\u7684\u66ff\u4ee3\u4ea7\u54c1\u6216TNF\u6291\u5236\u5242\u6cbb\u7597\u5931\u8d25\u540e\u7684\u4e8c\u7ebf\u7528\u836f\u3002<\/span><\/p>\n


                <\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

                \n
                \n
                \n

                \u9664\u751f\u7269\u836f\u4e4b\u5916\uff0cUpadacitinib\u4e5f\u5c06\u9762\u4e34\u6765\u81ea\u5176\u4ed6JAK\u6291\u5236\u5242\u7684\u76f4\u63a5\u7ade\u4e89\u3002\u8be5\u9886\u57df\u7684First-in-Class\u836f\u7269Xeljanz\u662f\u4e00\u79cd\u5e7f\u8c31JAK\u6291\u5236\u5242\uff0c\u5176\u7597\u6548\u4e0eHumira\u76f8\u5f53\u3002\u7f8e\u56fd\u98ce\u6e7f\u75c5\u5b66\u4f1a\u5efa\u8bae\u5176\u4f5c\u4e3a\u751f\u7269\u836f\u6cbb\u7597\u5931\u8d25\u7684\u4e8c\u7ebf\u7528\u836f\u30022017\u5e74\uff0cXeljanz\u7684\u9500\u552e\u989d\u4e3a13.5\u4ebf\u7f8e\u5143\uff0c\u9884\u8ba12023\u5e74\u5c06\u589e\u81f331.9\u4ebf\u7f8e\u5143\u3002<\/span><\/p>\n


                <\/p>\n

                Eli Lilly\u548cIncells\u7684Olumiant\u4e3aJAK1\/JAK2\u7684\u9009\u62e9\u6027\u6291\u5236\u5242\uff0c\u4e34\u5e8a\u6570\u636e\u663e\u793a\u5176\u7597\u6548\u4f18\u4e8eHumira\u30022017\u5e74\u8be5\u836f\u8fdb\u5165\u6b27\u76df\u548c\u65e5\u672c\u5e02\u573a\uff0c2018\u5e74\u8fdb\u5165\u7f8e\u56fd\u5e02\u573a\u3002\u5e02\u573a\u65b9\u9762\uff0c2017\u5e74Olumiant\u7684\u9500\u552e\u989d\u4e3a4500\u4e07\u7f8e\u91d1\uff0c\u9884\u8ba12023\u5e74\u7684\u9500\u552e\u989d\u5c06\u7a81\u783410.6\u4ebf\u7f8e\u91d1\uff08\u7ea6\u4e3aUpadacitinib\u7684\u4e00\u534a\uff09\u3002Olumiant\u540c\u6837\u4e5f\u9762\u4e34\u8bf8\u591a\u6311\u6218\uff1a\u4f8b\u5982\uff0c\u5176\u6807\u7b7e\u4e0a\u7684\u9ed1\u6846\u8b66\u544a\u6bd4\u5176 \u201c\u524d\u8f88\u201dXeljanz\u7684\u66f4\u5e7f\u6cdb\u3002<\/span><\/p>\n

                Olumiant\u67092mg\u548c4mg\u4e24\u79cd\u89c4\u683c\u3002RA-BEAM\u8bd5\u9a8c\u663e\u793a\uff0c4mg\u7684\u5242\u91cf\u7597\u6548\u4f18\u4e8eHumira\uff0c\u4f46\u8f83\u9ad8\u7684\u5242\u91cf\u5bfc\u81f4\u4e86\u8f83\u9ad8\u7684\u5b89\u5168\u6027\u98ce\u9669\uff0c\u57fa\u4e8e\u6b64\uff0cFDA\u53ea\u6279\u51c6\u4e86\u8be5\u836f2mg\u7684\u5242\u91cf\u3002\u4e0d\u8fc7\uff0c\u8be5\u5c40\u9650\u6027\u4e0d\u7ecf\u610f\u95f4\u4e3aUpadacitinib\u63d0\u4f9b\u4e86\u6f5c\u5728\u5e02\u573a\u673a\u4f1a\u3002<\/span><\/p>\n


                <\/p>\n<\/section>\n<\/section>\n<\/section>\n

                \n
                \n
                \n

                Upadacitinib\u3001Xeljanz\u3001Olumiant<\/span><\/p>\n

                \u4e09\u4e2a\u836f\u7269\u7684\u5e02\u573a\u9884\u6d4b<\/span><\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

                \n
                \n
                \"\u79d1\u777f\u552f\u5b89\u300a\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u9884\u6d4b\u300b2019\u5e74\u5ea6\u62a5\u544a\u5168\u6587\uff08\u4e0a\uff09\"<\/section>\n<\/section>\n
                \n
                Source: Cortellis<\/span><\/section>\n<\/section>\n<\/section>\n
                \n
                \n
                \n
                \n
                \n
                \n

                2. \u810a\u9ad3\u6027\u808c\u840e\u7f29\u75c7\u65b0\u836f\uff1aZolgensma<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

                \n
                \n
                \n


                <\/p>\n<\/section>\n<\/section>\n<\/section>\n

                \n
                \n
                \n

                2016\u5e74\uff0c\u8be5\u9886\u57df\u7684First-in-Class\u836f\u7269Spinraza\u5728\u7f8e\u56fd\u4e0a\u5e02\uff0c2017\u5e74\u5728\u6b27\u76df\u4e0a\u5e02\uff0c\u8be5\u836f\u66fe\u83b7\u5b64\u513f\u836f\u7269\u4e0e\u7a81\u7834\u7597\u6cd5\u8d44\u683c\u3002Zolgensma\u4e0a\u5e02\u540e\u5c06\u9762\u4e34Spinraza\u7684\u6fc0\u70c8\u7ade\u4e89\u3002<\/span><\/p>\n


                <\/p>\n

                \u810a\u9ad3\u6027\u808c\u840e\u7f29\u75c7\u662f\u4e00\u79cd\u8868\u73b0\u4e3a\u808c\u8089\u6d88\u7626\u7684\u75be\u75c5\uff0c\u4e3b\u8981\u5f71\u54cd\u5a74\u513f\u548c\u513f\u7ae5\uff0c\u4e14\u5e74\u9f84\u8d8a\u5c0f\u81f4\u6b7b\u7387\u8d8a\u9ad8\u3002\u8be5\u75be\u75c5\u53d1\u75c5\u7387\u57281\/8000-1\/11000\u4e4b\u95f4\u3002\u4ece\u53d1\u75c5\u673a\u5236\u6765\u770b\uff0c\u8be5\u75be\u75c5\u662f\u7531SMN1\u57fa\u56e0\u7a81\u53d8\u5f15\u8d77\u7684\uff0c\u8be5\u7a81\u53d8\u963b\u65ad\u4e86\u8fd0\u52a8\u795e\u7ecf\u5143\u5b58\u6d3b\u86cb\u767d(SMN)\u7684\u4ea7\u751f\uff0c\u800cSMN\u86cb\u767d\u662f\u5927\u8111\u5411\u808c\u8089\u4f20\u9012\u8fd0\u52a8\u4fe1\u53f7\u6240\u5fc5\u9700\u7684\u86cb\u767d\u3002\u60a3\u8005\u4e0d\u4ec5\u8868\u73b0\u4e3a\u808c\u8089\u65e0\u529b\u548c\u6d88\u7626\uff0c\u901a\u5e38\u8fd8\u5b58\u5728\u8fd0\u52a8\u3001\u547c\u5438\u548c\u541e\u54bd\u969c\u788d\u7b49\u3002<\/span><\/p>\n


                <\/p>\n

                \u9664\u4e86SMN1\u57fa\u56e0\u5916\uff0c\u4eba\u4f53\u5185\u8fd8\u6709\u4e0e\u4e4b\u7c7b\u4f3c\u7684SMN2\u57fa\u56e0\u3002SMN2\u4ea7\u751f\u7684SMN\u86cb\u767d\u5927\u90e8\u5206\u662f\u65e0\u529f\u80fd\u7684\uff0c\u4e0d\u80fd\u5f25\u8865SMN1\u7a81\u53d8\u5f15\u8d77\u7684SMN\u86cb\u767d\u7f3a\u9677\u3002\u4f46\u5e86\u5e78\u7684\u662f\uff0cSMN2\u57fa\u56e0\u4ea7\u751f\u7684\u529f\u80fd\u6027\u86cb\u767d\uff0c\u53ef\u4ee5\u5ef6\u7f13\u8be5\u75be\u75c5\u75c5\u60c5\u7684\u53d1\u751f\u5e76\u51cf\u8f7b\u75be\u75c5\u75c7\u72b6\u3002\u56e0\u6b64\uff0c\u4f5c\u7528SMN2\u57fa\u56e0\u53ef\u4ee5\u8d77\u5230\u5ef6\u7f13\u75be\u75c5\u8fdb\u5c55\u7684\u76ee\u7684\u3002<\/span><\/p>\n


                <\/p>\n

                \u8be5\u75be\u75c5\u6309\u53d1\u75c5\u5e74\u9f84\u548c\u4e25\u91cd\u7a0b\u5ea6\u53ef\u4ee5\u5206\u4e3a4\u7c7b\u3002\u6700\u5e38\u89c1\u7684\u662f\u2160\u578b\uff0c\u4e5f\u662f\u4e25\u91cd\u7a0b\u5ea6\u6700\u9ad8\u7684\u4e00\u7c7b\u3002\u5728\u51fa\u751f\u540e\u51e0\u4e2a\u6708\u5185\u5c31\u660e\u663e\u53ef\u89c1\uff0c\u6781\u6613\u5bfc\u81f4\u513f\u7ae5\u65e9\u671f\u547c\u5438\u8870\u7aed\u6b7b\u4ea1\uff1bII\u578b\u53d1\u75c5\u5e74\u9f84\u57286\u523012\u4e2a\u6708\u4e4b\u95f4\uff0c\u60a3\u8005\u53ef\u80fd\u6d3b\u523020\u621630\u5c81\uff1bIII\u578b(\u5e74\u9f84\u8f83\u5927\u7684\u513f\u7ae5)\u548cIV\u578b(\u6210\u4eba)\u7684\u60a3\u8005\u901a\u5e38\u6709\u6b63\u5e38\u7684\u9884\u671f\u5bff\u547d\u3002<\/span><\/p>\n


                <\/p>\n

                Zolgensma<\/strong><\/span><\/strong><\/strong><\/span><\/p>\n

                Zolgensma\u7531AveXis\u4e0e\u8bfa\u534e\u8054\u5408\u5f00\u53d1\uff0c\u4e3a\u4e00\u79cd\u901a\u8fc7\u6ce8\u5c04\u7ed9\u836f\u7684\u57fa\u56e0\u6cbb\u7597\u836f\u7269\u3002\u5b83\u901a\u8fc7\u75c5\u6bd2\u8f7d\u4f53\u5c06\u4e00\u79cd\u529f\u80fd\u6027SMN\u86cb\u767d\u7684DNA\u5bfc\u5165\u60a3\u8005\u7ec6\u80de\u30022018\u5e74\u7b2c3\u5b63\u5ea6\uff0cAveXis\u5411\u7f8e\u56fd\u3001\u6b27\u76df\u548c\u65e5\u672c\u63d0\u4ea4\u4e86Zolgensma\u7528\u4e8e\u6cbb\u7597I\u578b\u810a\u9ad3\u6027\u808c\u840e\u7f29\u75c7\u7684\u4e0a\u5e02\u7533\u8bf7\u3002\u516c\u53f8\u9884\u8ba1\u8be5\u4ea7\u54c1\u5c06\u57282019\u5e74\u4e0a\u534a\u5e74\u83b7\u6279\u3002\u636eCortellis\u9884\u6d4b\uff0c\u8be5\u836f\u5728\u4ee5\u4e0a\u4e09\u4e2a\u56fd\u5bb6\u548c\u5730\u533a\u7684\u83b7\u6279\u6210\u529f\u7387\u5747\u4e3a95%\u3002\u9884\u8ba1\u4eca\u5e74\u7684\u9500\u552e\u989d\u5c06\u8fbe\u52307.6\u4ebf\u7f8e\u91d1\uff0c2020\u5e74\u589e\u81f312.7\u4ebf\u7f8e\u91d1\uff0c2023\u5e74\u5c06\u7a81\u783422.3\u4ebf\u7f8e\u91d1\u3002<\/span><\/span><\/p>\n


                <\/p>\n<\/section>\n<\/section>\n<\/section>\n

                \n
                \n
                \n

                Zolgensma\u4e0a\u5e02\u65f6\u95f4\u53ca\u6210\u529f\u7387\u9884\u6d4b<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

                \n
                \n
                \"\u79d1\u777f\u552f\u5b89\u300a\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u9884\u6d4b\u300b2019\u5e74\u5ea6\u62a5\u544a\u5168\u6587\uff08\u4e0a\uff09\"<\/section>\n<\/section>\n

                \"\u79d1\u777f\u552f\u5b89\u300a\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u9884\u6d4b\u300b2019\u5e74\u5ea6\u62a5\u544a\u5168\u6587\uff08\u4e0a\uff09\"<\/p>\n<\/section>\n

                \"\u79d1\u777f\u552f\u5b89\u300a\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u9884\u6d4b\u300b2019\u5e74\u5ea6\u62a5\u544a\u5168\u6587\uff08\u4e0a\uff09\"<\/p>\n

                \n
                \n
                \n

                Source: Cortellis Analytics \u2013 Drug Timeline & Success Rates<\/span><\/p>\n


                <\/p>\n<\/section>\n<\/section>\n<\/section>\n

                \n
                \n
                \n

                \u4e34\u5e8a\u4f18\u52bf\u65b9\u9762\uff0c\u5728\u4e00\u9879\u540d\u4e3aSTART\u7684I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c15\u4f8b\u2160\u578bSMA\u60a3\u513f\u572824\u4e2a\u6708\u5185\u5168\u90e8\u5b58\u6d3b\u3002\u8fd9\u4e0e\u81ea\u7136\u75be\u75c5\u8fdb\u5c55\u8fc7\u7a0b\u4e2d\u9ad8\u8fbe90%\u7684\u6b7b\u4ea1\u7387\u6216\u6c38\u4e45\u6027\u547c\u5438\u8f85\u52a9\u76f8\u6bd4\u6709\u4e86\u6781\u5927\u7684\u6539\u5584\u3002\u6b64\u5916\uff0c\u53e6\u4e00\u9879\u540d\u4e3aSTR1VE\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u521d\u6b65\u6570\u636e\u663e\u793a\uff0c\u60a3\u8005\u7684\u8fd0\u52a8\u529f\u80fd\u5f97\u5230\u4e86\u5feb\u901f\u7684\u6539\u5584\u3002<\/span><\/p>\n


                <\/p>\n

                \u9664\u4ee5\u4e0a\u4e34\u5e8a\u8bd5\u9a8c\u5916\uff0c\u5176\u4ed6\u7c7b\u578bSMA\u7684\u8bd5\u9a8c\u4e5f\u5728\u6709\u6761\u4e0d\u7d0a\u5730\u8fdb\u884c\u4e2d\uff0c\u5305\u62ecSPR1NT\u8bd5\u9a8c\uff08\u53d7\u8bd5\u8005\uff1a6\u5468\u4ee5\u4e0b\u6709\u75c7\u72b6\u7684\u513f\u7ae5\uff1b\u9002\u5e94\u75c7\uff1aII\u578b\u3001III\u578b\u548c\u2163\u578bSMA\uff09\u3001STRONG\u8bd5\u9a8c\uff08\u53d7\u8bd5\u8005\uff1a6\u4e2a\u6708\u81f35\u5c81\u7684\u513f\u7ae5\uff1b\u9002\u5e94\u75c7\uff1aII\u578bSMA\uff09\uff0c\u4ee5\u53ca\u8ba1\u5212\u5f00\u5c55\u7684REACH\u8bd5\u9a8c\uff08\u53d7\u8bd5\u8005\uff1a6\u4e2a\u6708\u81f318\u5c81\u60a3\u8005\uff1b\u9002\u5e94\u75c7\uff1aII\u578b\u3001III\u578b\u548c\u2163\u578bSMA\uff09\u3002<\/span><\/p>\n


                <\/p>\n<\/section>\n<\/section>\n<\/section>\n

                \n
                \n
                \n

                \u810a\u9ad3\u6027\u808c\u840e\u7f29\u75c7\u5e02\u573a<\/strong><\/span><\/strong><\/strong><\/span><\/p>\n

                \u5982\u679cZolgensma\u6210\u529f\u83b7\u6279\uff0c\u5b83\u5c06\u9762\u4e34\u4e00\u4e2a\u6fc0\u70c8\u7684\u5e02\u573a\u7ade\u4e89\u683c\u5c40\u3002<\/span><\/p>\n


                <\/p>\n

                Ionis\u5236\u836f\u548cBiogen\u8054\u5408\u5f00\u53d1\u7684Spinraza\u662f\u4e00\u79cd\u53cd\u4e49\u5be1\u6838\u82f7\u9178\uff0c\u901a\u8fc7\u4fee\u9970SMN2\u57fa\u56e0\uff0c\u5f71\u54cdSMN\u86cb\u767d\u7684\u7ffb\u8bd1\uff0c\u589e\u52a0\u529f\u80fd\u6027SMN\u86cb\u767d\u7684\u4ea7\u751f\u30022016\u5e7412\u6708\uff0cSpinraza\u5728\u7f8e\u56fd\u83b7\u6279\uff0c\u6210\u4e3a\u7f8e\u56fd\u7b2c\u4e00\u4e2a\u7528\u4e8eSMA\u6cbb\u7597\u7684\u836f\u7269\u30022017\u5e746\u6708\uff0cSpinraza\u53c8\u5728\u6b27\u76df\u83b7\u6279\u30022017\u5e74\uff0c\u8be5\u836f\u5b9e\u73b0\u5168\u7403\u9500\u552e\u6536\u51658.83\u4ebf\u7f8e\u91d1\uff0cCortellis\u9884\u6d4b2023\u5e74\u8be5\u836f\u9500\u552e\u989d\u5c06\u7a81\u783422.7\u4ebf\u7f8e\u91d1\u3002<\/span><\/p>\n


                <\/p>\n

                \u4ece\u83b7\u6279\u8303\u56f4\u6765\u770b\uff0c\u4e0eSpinraza\u88ab\u6279\u51c6\u7528\u4e8e\u6240\u6709\u7c7b\u578b\u7684SMA\u76f8\u6bd4\uff0cZolgensma\u76ee\u524d\u53ea\u83b7\u6279\u7528\u4e8eI\u578bSMA\u7684\u6cbb\u7597\uff0c\u4f3c\u4e4e\u4e0d\u5360\u6709\u4f18\u52bf\u3002\u7136\u800c\uff0c\u4ece\u987a\u5e94\u6027\u7684\u89d2\u5ea6\uff0cZolgensma\u901a\u8fc7\u9759\u8109\u6ce8\u5c04\u4e00\u6b21\u6027\u5b8c\u6210\u7ed9\u836f\uff0c\u800cSpinraza\u5fc5\u987b\u6bcf4\u4e2a\u6708\u901a\u8fc7\u8170\u7a7f(\u9798\u5185)\u6ce8\u5165\u8111\u810a\u6db2\uff0cZolgensma\u66f4\u80dc\u4e00\u7b79\u3002<\/span><\/p>\n


                <\/p>\n

                \u5f53\u7136\uff0c\u4e3a\u4e86\u5f25\u8865Zolgensma\u5728\u9002\u5e94\u75c7\u83b7\u6279\u8303\u56f4\u4e0a\u7684\u4e0d\u8db3\uff0cAveXis\u6b63\u5728\u79ef\u6781\u5f00\u5c55\u76f8\u5173\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4ee5\u671f\u5c06Zolgensma\u7684\u4f7f\u7528\u8303\u56f4\u6269\u5927\u5230\u5176\u4ed6\u7c7b\u578bSMA\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u5728\u987a\u5e94\u6027\u65b9\u9762\uff0cAveXis\u4e5f\u5c1d\u8bd5\u4e86\u987a\u5e94\u6027\u8f83\u5dee\u7684\u9798\u5185\u7ed9\u836f\uff08STRONG\u548cREACH\u4e24\u4e2a\u8bd5\u9a8c\uff09\uff0c\u4f46\u7ed9\u836f\u9891\u7387\u4ecd\u7136\u662f\u4e00\u6b21\u6027\u7ed9\u836f\uff0c\u8fd9\u4e00\u70b9\u8f83\u5e38\u89c4\u7684\u6301\u7eed\u6027\u7ed9\u836f\u66f4\u6709\u4f18\u52bf\u3002Cortellis\u9884\u6d4b\uff0c2019\u5e74\u4e0b\u534a\u5e74\uff0cAveXis\u5c06\u63d0\u4ea4Zolgensma\u7528\u4e8e\u6cbb\u7597II\u578b\u548cIII\u578bSMA\u7684\u4e0a\u5e02\u7533\u8bf7\u3002<\/span><\/p>\n


                <\/p>\n

                \u9664Spinraza\u5916\uff0c\u5904\u4e8e\u7814\u53d1\u9636\u6bb5\u5e76\u80fd\u5728\u672a\u6765\u4e0eZolgensma\u5f62\u6210\u6b63\u9762\u7ade\u4e89\u7684\u836f\u7269\u4e0d\u591a\u3002\u5176\u4e2d\u6bd4\u8f83\u6709\u6f5c\u529b\u7684\u662f\u7f57\u6c0f\u7684Risdiwam\u548c\u8bfa\u534e\u7684Branaplam\u3002\u4ed6\u4eec\u7684\u4f5c\u7528\u673a\u5236\u4e0eSpinraza\u4e00\u6837\uff0c\u5747\u901a\u8fc7\u4fee\u6539SMN2\u57fa\u56e0\u8d77\u6548\u3002<\/span><\/p>\n


                <\/p>\n

                Risdiwam\u76ee\u524d\u7684\u6700\u9ad8\u72b6\u6001\u4e3aII\/III\u671f\u4e34\u5e8a (SUNFISH\u8bd5\u9a8c\uff1aII\u578b\u548cIII\u578bSMA\uff1bFIREFISH \u8bd5\u9a8c\uff1aI\u578bSMA)\u3002\u6839\u636eCortellis\u9884\u6d4b\uff0c\u8be5\u836f\u9884\u8ba12020\u5e74\u83b7\u6279\uff0c\u5728\u7f8e\u56fd\u3001\u6b27\u76df\u548c\u65e5\u672c\u7684\u83b7\u6279\u6210\u529f\u7387\u5747\u8d85\u8fc780%\u3002\u5e02\u573a\u9884\u6d4b\u65b9\u9762\uff0c2023\u5e74\u7684\u9500\u552e\u989d\u5c06\u7a81\u78346.45\u4ebf\u7f8e\u91d1\u3002<\/span><\/p>\n


                <\/p>\n

                Branaplam\u76ee\u524d\u5904\u4e8eII\u671f\u4e34\u5e8a\uff08I\u578bSMA\uff09\u3002Cortellis\u9884\u6d4b\uff0c\u8be5\u836f2023\u5e74\u8fdb\u5165\u5e02\u573a\uff0c\u5728\u6b27\u76df\u7684\u83b7\u6279\u6210\u529f\u7387\u4e3a50%\uff0c\u9884\u8ba1\u4e0a\u5e02\u5f53\u5e74\u7684\u9500\u552e\u989d\u4e3a2500\u4e07\u7f8e\u91d1\u3002<\/span><\/p>\n


                <\/p>\n

                \u9664\u4ee5\u4e0a3\u4e2a\u836f\u7269\u5916\uff0cCytokinetics\u548cAstellas\u8054\u5408\u5f00\u53d1\u7684Reldesemtiv\u4e5f\u662f\u8be5\u9886\u57df\u7684\u91cd\u8981\u53c2\u8d5b\u8005\uff0c\u4ece\u4f5c\u7528\u673a\u5236\u6765\u770b\uff0cReldesemtiv\u7684\u4f5c\u7528\u673a\u5236\u4e0e\u5176\u4ed6\u836f\u7269\u4e0d\u540c\uff0c\u8be5\u836f\u901a\u8fc7\u4f5c\u7528\u4e8e\u808c\u8089\u7ea4\u7ef4\uff0c\u63d0\u9ad8\u795e\u7ecf\u5143\u523a\u6fc0\u7684\u53cd\u5e94\u6027\u6cbb\u7597SMA\u3002\u9664\u8be5\u9002\u5e94\u5916\uff0c\u8be5\u836f\u7528\u4e8e\u808c\u8089\u529f\u80fd\u6027\u969c\u788d\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e5f\u5728\u8fdb\u884c\u4e2d\u3002Cortellis\u9884\u6d4b\uff0c\u8be5\u836f\u5728\u7f8e\u56fd\u7684\u83b7\u6279\u6210\u529f\u7387\u4e3a43%\uff0c\u9884\u8ba12023\u5e74\uff0c\u9500\u552e\u989d\u5c06\u7a81\u78346.67\u4ebf\u7f8e\u91d1\u3002<\/span><\/p>\n


                <\/span><\/p>\n

                \n
                \n
                \n
                \n

                Zolgensma, Spinraza, Risdiplam, Branaplam , Reldesemtiv<\/span><\/p>\n

                \u4e94\u4e2a\u836f\u7269\u7684\u5e02\u573a\u9884\u6d4b<\/span><\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

                \n
                \n
                \"\u79d1\u777f\u552f\u5b89\u300a\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u9884\u6d4b\u300b2019\u5e74\u5ea6\u62a5\u544a\u5168\u6587\uff08\u4e0a\uff09\"<\/section>\n<\/section>\n
                \n
                Source: Cortellis<\/span><\/section>\n<\/section>\n
                <\/section>\n<\/section>\n<\/section>\n
                \n
                \n
                \n
                \n
                \n
                \n

                3. \u6162\u6027\u80be\u75c5\u8d2b\u8840\u65b0\u836f\uff1aRoxadustat<\/strong><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n


                <\/p>\n<\/section>\n

                \n
                \n
                \n

                \u8be5\u9886\u57df\u5df2\u4e0a\u5e02\u7684\u836f\u7269\u56e0\u8f83\u9ad8\u7684\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u548c\u81f4\u764c\u98ce\u9669\uff0c\u4e3aRoxadustat\u521b\u9020\u4e86\u673a\u4f1a\u3002<\/span><\/p>\n


                <\/p>\n

                \u5728\u6162\u6027\u80be\u75c5\u60a3\u8005\u4e2d\uff0c\u8d2b\u8840\u4e3a\u5e38\u89c1\u7684\u5e76\u53d1\u75c7\uff0c\u4e14\u968f\u7740\u80be\u75c5\u7684\u8fdb\u5c55\u800c\u9010\u6b65\u6076\u5316\u3002\u4e3b\u8981\u539f\u56e0\u6709\u4e24\u4e2a\uff1a<\/span><\/p>\n


                <\/p>\n

                1. \u80be\u810f\u4e0d\u80fd\u4ea7\u751f\u8db3\u591f\u7684\u7ea2\u7ec6\u80de\u751f\u6210\u6240\u5fc5\u9700\u7684\u4fc3\u7ea2\u7ec6\u80de\u751f\u6210\u7d20\u3002<\/span><\/p>\n

                2. \u8bb8\u591a\u80be\u75c5\u60a3\u8005\u540c\u65f6\u4e5f\u7f3a\u4e4f\u7ea2\u7ec6\u80de\u6240\u9700\u7684\u94c1\uff08\u4f8b\u5982\u5728\u80be\u810f\u900f\u6790\u8fc7\u7a0b\u4e2d\u5931\u8840\uff09\u3002<\/span><\/p>\n


                <\/p>\n

                \u56e0\u6b64\uff0c\u5927\u591a\u6570\u6162\u6027\u80be\u75c5\u8fdb\u5c55\u4e3a\u80be\u529f\u80fd\u8870\u7aed\u7684\u60a3\u8005\u90fd\u4f34\u6709\u8d2b\u8840\u3002\u4ece\u5168\u7403\u53d1\u75c5\u4eba\u6570\u6765\u770b\uff0c\u6162\u6027\u80be\u75c5\u5f71\u54cd\u5230\u5168\u74032\u4ebf\u4eba\u3002<\/span><\/p>\n


                <\/p>\n

                Roxadustat<\/strong><\/span><\/strong><\/span><\/p>\n

                Roxadustat\u662f\u7531AstraZeneca\/FibroGen\/Astella\u4e09\u5bb6\u8054\u5408\u5f00\u53d1\u7684\u7528\u4e8e\u6162\u6027\u80be\u75c5\u8d2b\u8840\u7684\u6cbb\u7597\u836f\u7269\uff0c\u4e3a\u7f3a\u6c27\u8bf1\u5bfc\u56e0\u5b50-\u812f\u6c28\u9178\u7f9f\u5316\u9176(HIF-PH)\u6291\u5236\u5242\u7684First-in-Class\u3002\u4ece\u4f5c\u7528\u673a\u5236\u6765\u770b\uff0c\u812f\u6c28\u9178\u7f9f\u5316\u9176\u662f\u4e00\u79cd\u5206\u89e3\u7f3a\u6c27\u8bf1\u5bfc\u56e0\u5b50\u7684\u9176\uff0c\u540e\u8005\u53c2\u4e0e\u4fc3\u7ea2\u7ec6\u80de\u751f\u6210\u7d20(EPO)\u548c\u94c1\u7684\u751f\u6210\u3002Roxadustat\u901a\u8fc7\u6291\u5236\u812f\u6c28\u9178\u7f9f\u5316\u9176\uff0c\u4fdd\u62a4\u7f3a\u6c27\u8bf1\u5bfc\u56e0\u5b50\uff0c\u523a\u6fc0EPO\u548c\u94c1\u7684\u751f\u6210\uff0c\u8fdb\u800c\u4fc3\u8fdb\u7ea2\u7ec6\u80de\u7684\u4ea7\u751f\u3002Cortellis\u9884\u6d4b\uff0c\u8be5\u836f2023\u5e74\u7684\u9500\u552e\u5c06\u8fbe\u52301.7\u4ebf\u7f8e\u91d1\u3002
                <\/span><\/p>\n


                <\/p>\n

                2018\u5e7412\u6708\uff0c\u8be5\u836f\u5728\u4e2d\u56fd\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u201c\u80be\u900f\u6790\u4f9d\u8d56\u578b\u6162\u6027\u80be\u75c5\u8d2b\u8840\u201d\u3002\u9884\u8ba1\u5c06\u4e8e2019\u5e74\u4e0b\u534a\u5e74\u4e0a\u5e02\u3002\u6b64\u5916\uff0c\u8be5\u836f\u7528\u4e8e\u201c\u975e\u80be\u900f\u6790\u4f9d\u8d56\u578b\u6162\u6027\u80be\u75c5\u8d2b\u8840\u201d\u7684\u4e0a\u5e02\u7533\u8bf7\u4e5f\u5df2\u7ecf\u9012\u4ea4\u5230NMPA\uff0c\u4e00\u65e6\u4e2d\u56fd\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u5b8c\u6210\u73b0\u573a\u68c0\u67e5\uff0c\u8be5\u9002\u5e94\u75c7\u5c06\u5f88\u5feb\u83b7\u6279\u3002<\/span><\/p>\n


                <\/p>\n<\/section>\n<\/section>\n<\/section>\n

                \n
                \n
                \n

                Roxadustat\u7684\u4e0a\u5e02\u65f6\u95f4\u53ca\u6210\u529f\u7387\u9884\u6d4b<\/span><\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

                \n
                \"\u79d1\u777f\u552f\u5b89\u300a\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u9884\u6d4b\u300b2019\u5e74\u5ea6\u62a5\u544a\u5168\u6587\uff08\u4e0a\uff09\"<\/section>\n<\/section>\n
                \n
                \n
                \n

                Source: Cortellis Analytics \u2013 Drug Timeline & Success Rates<\/span><\/p>\n


                <\/p>\n<\/section>\n<\/section>\n<\/section>\n

                \n
                \n
                \n

                \u8be5\u836f\u5728\u4e2d\u56fd\u7684\u9996\u6b21\u83b7\u6279\uff0c\u662f\u57fa\u4e8e\u4e00\u9879\u540d\u4e3aFGCL-4592-806\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8bd5\u9a8c\u6570\u636e\u663e\u793a\uff1a\u5728\u900f\u6790\u60a3\u8005\u8840\u7ea2\u86cb\u767d\u6c34\u5e73\u63d0\u5347\uff0823-27\u5468\uff09\u65b9\u9762\uff0cRoxadustat\u975e\u52a3\u6548\u4e8eEpoetin Alfa\uff08\u4e00\u79cd\u7ea2\u7ec6\u80de\u751f\u6210\u523a\u6fc0\u56e0\u5b50\uff09\u3002\u6b64\u5916\uff0cRoxadustat\u5728\u589e\u52a0\u8f6c\u94c1\u86cb\u767d\u3001\u7ef4\u6301\u8840\u6e05\u94c1\u6c34\u5e73\u3001\u51cf\u7f13\u94c1\u86cb\u767d\u9971\u548c\u5ea6\u7684\u4e0b\u964d\u7a0b\u5ea6\u7b49\u65b9\u9762\u5747\u8868\u73b0\u51fa\u4e86\u8f83\u597d\u4e34\u5e8a\u6548\u679c\uff1b\u5728\u975e\u900f\u6790\u60a3\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff08FGCL-4592-808\u8bd5\u9a8c\uff09\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0cRoxadustat\u5728\u8840\u7ea2\u86cb\u767d\u6c34\u5e73\u7684\u63d0\u5347\u65b9\u9762\u540c\u6837\u8868\u73b0\u51fa\u4e86\u660e\u663e\u7684\u4f18\u52bf\u3002<\/span><\/p>\n


                <\/p>\n

                \u9664\u5728\u4e2d\u56fd\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e4b\u5916\uff0c\u5728\u7f8e\u56fd\u5f00\u5c55\u7684\u201c\u80be\u900f\u6790\u4f9d\u8d56\u578b\u6162\u6027\u80be\u75c5\u8d2b\u8840\u201d\u7684\u5173\u952e\u6027III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08ROCKIES\u8bd5\u9a8c\uff09\uff0c\u4ee5\u53ca\u5728\u6b27\u6d32\u5f00\u5c55\u7684\u201c\u975e\u80be\u900f\u6790\u4f9d\u8d56\u578b\u6162\u6027\u80be\u75c5\u8d2b\u8840\u201d\u7684\u5173\u952e\u6027III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08OLYMPUS\u8bd5\u9a8c\uff09\u4e2d\uff0cRoxadustat\u5747\u8fbe\u5230\u4e86\u9884\u8bbe\u7684\u4e3b\u8981\u4e34\u5e8a\u7ec8\u70b9\u3002\u8fd9\u4e9b\u8bd5\u9a8c\u7ed3\u679c\u65e0\u7591\u7ed9\u6162\u6027\u80be\u75c5\u8d2b\u8840\u60a3\u8005\u5e26\u6765\u4e86\u5de8\u5927\u7684\u5e0c\u671b\u3002<\/span><\/p>\n


                <\/p>\n

                \u6162\u6027\u80be\u75c5\u8d2b\u8840\u7684\u5e02\u573a<\/strong><\/span><\/strong><\/strong><\/span><\/p>\n

                \u5728\u6162\u6027\u80be\u810f\u8d2b\u8840\u9886\u57df\uff0c\u7ea2\u7ec6\u80de\u751f\u6210\u523a\u6fc0\u56e0\u5b50\uff08ESA\uff09\u5728\u4e34\u5e8a\u4e0a\u5df2\u7ecf\u5e94\u7528\u4e86\u51e0\u5341\u5e74\uff0c\u5e76\u5360\u636e\u4e86\u7edd\u5bf9\u7684\u4e3b\u5bfc\u5730\u4f4d\u3002\u4f46\u6700\u8fd1\u51e0\u5e74\u7684\u5faa\u8bc1\u533b\u5b66\u8868\u660e\uff0c\u6b64\u7c7b\u836f\u7269\u4e0e\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u548c\u80bf\u7624\u7684\u98ce\u9669\u6709\u8f83\u9ad8\u7684\u76f8\u5173\u6027\u3002\u8fd9\u4e00\u4e34\u5e8a\u4e0d\u8db3\u4e3a\u8be5\u9886\u57df\u7684\u65b0\u836f\u63d0\u4f9b\u4e86\u5e7f\u9614\u7684\u5e02\u573a\u7a7a\u95f4\u3002
                <\/span><\/p>\n


                <\/p>\n

                \u4e34\u5e8a\u4e0a\uff0c\u4e3a\u4e86\u89c4\u907f\u6b64\u7c7b\u836f\u7269\u7684\u5b89\u5168\u6027\u98ce\u9669\uff0c\u60a3\u8005\u5728\u63a5\u53d7ESAs\u6cbb\u7597\u7684\u540c\u65f6\uff0c\u901a\u5e38\u4f1a\u8054\u7528\u5176\u4ed6\u836f\u7269\uff0c\u5305\u62ec\u6297\u9ad8\u8840\u538b\u3001\u6297\u51dd\u8840\u4ee5\u53ca\u9759\u8109\u94c1\u5242\uff08\u4e4b\u6240\u4ee5\u8054\u7528\u94c1\u5242\uff0c\u662f\u56e0\u4e3aESAs\u5728\u8840\u7ea2\u86cb\u767d\u6c34\u5e73\u7ea0\u6b63\u8fc7\u7a0b\u4e2d\u5bb9\u6613\u964d\u4f4e\u94c1\u6c34\u5e73\uff0c\u4ece\u800c\u5bfc\u81f4\u673a\u4f53\u529f\u80fd\u6027\u7f3a\u94c1\uff09\u3002<\/span><\/p>\n


                <\/p>\n

                \u4e0e\u53ef\u6ce8\u5c04\u7684ESA\u76f8\u6bd4\uff0cRoxadustat\u901a\u8fc7\u53e3\u670d\u7ed9\u836f\uff0c\u4e14\u65e0\u9700\u4e0e\u4ee5\u4e0a\u836f\u7269\u8054\u7528\uff0c\u987a\u5e94\u6027\u63d0\u9ad8\u7684\u540c\u65f6\uff0c\u6cbb\u7597\u8d39\u7528\u4e5f\u5927\u5927\u964d\u4f4e\u3002\u66f4\u91cd\u8981\u7684\uff0c\u4e0eESA\u7684\u9ad8\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u98ce\u9669\u76f8\u6bd4\uff0cRoxadustat\u4e0d\u4ec5\u4e0d\u589e\u52a0\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u98ce\u9669\uff0c\u53cd\u800c\u964d\u4f4e\u60a3\u8005\u7684\u5fc3\u8840\u7ba1\u98ce\u9669\u3002\u4e34\u5e8a\u6570\u636e\u8868\u660e\uff0cRoxadustat\u4e0e\u5fc3\u8840\u7ba1\u4e8b\u4ef6\u6216\u8840\u6813\u5f62\u6210\u65e0\u76f8\u5173\u6027\u3002\u4e00\u9879II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u60a3\u8005\u7684\u5e73\u5747\u52a8\u8109\u8840\u538b\u663e\u8457\u4e0b\u964d\uff0c\u672a\u89c2\u5bdf\u5230\u9ad8\u8840\u538b\u7684\u6076\u5316\u4e8b\u4ef6\u3002\u9664\u964d\u4f4e\u8840\u538b\u5916\uff0cRoxadustat\u8fd8\u80fd\u591f\u964d\u4f4e\u8840\u6db2\u4e2d\u7684\u80c6\u56fa\u9187\u6c34\u5e73\u3002\u7531\u4e8e\u8840\u8102\u5f02\u5e38\u548c\u9ad8\u8840\u538b\u5728\u6162\u6027\u80be\u75c5\u60a3\u8005\u4e2d\u975e\u5e38\u666e\u904d\uff0cRoxadustat\u7684\u8fd9\u4e00\u4e34\u5e8a\u4f18\u52bf\uff0c\u5c06\u662f\u5176\u4e0a\u5e02\u540e\u6781\u5927\u7684\u5356\u70b9\u3002<\/span><\/p>\n


                <\/p>\n

                \u7ade\u4e89\u65b9\u9762\uff0cGSK\u3001Akebia\u3001\u4e09\u83f1\u7530\u8fb9\u3001\u5927\u51a2\u7b49\u516c\u53f8\u5747\u662f\u8be5\u9886\u57df\u7684\u53c2\u8d5b\u8005\u3002\u5176\u4e2d\u6bd4\u8f83\u8457\u540d\u7684\u662fGSK\u7684Daprodustat\u548cAkebia\u7684Vadustat\u3002<\/span><\/p>\n


                <\/p>\n

                2016\u5e74\uff0cGSK\u542f\u52a8\u4e86\u4e0d\u540c\u7c7b\u578b\u7684\u6162\u6027\u80be\u75c5\u8d2b\u8840\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u30022018\u5e74\u516c\u5e03\u4e86\u9633\u6027\u6570\u636e\u540e(204716\u548c201754\u4e24\u9879\u6765\u81ea\u65e5\u672c\u7684\u4e34\u5e8a\u6570\u636e)\uff0cGSK\u8ba1\u5212\u4e8e2019\u5e74\u5728\u65e5\u672c\u9012\u4ea4\u4e0a\u5e02\u7533\u8bf7\u3002Cortellis\u9884\u6d4b\uff0c\u8be5\u836f\u5c06\u4e8e2020\u5e74\u5728\u65e5\u672c\u83b7\u6279\uff0c\u83b7\u6279\u6210\u529f\u738790%\u3002\u5728\u7f8e\u56fd\u548c\u6b27\u6d32\uff0cDaprodustat\u76ee\u524d\u5904\u4e8eIII\u671f\u4e34\u5e8a(ASPEND-ND\u548cASPEND-D)\uff0c\u9884\u8ba12020\u5e74\u5b8c\u6210\u3002Cortellis\u9884\u6d4b\uff0c Daprodustat\u5c06\u57282021\u5e74\u83b7\u7f8e\u56fd\u548c\u6b27\u76df\u6279\u51c6\uff0c\u83b7\u6279\u6210\u529f\u7387\u5747\u4e3a86%\u3002\u5e02\u573a\u65b9\u9762\uff0c\u9884\u8ba12023\u5e74\uff0cDaprodustat\u7684\u9500\u552e\u989d\u5c06\u7a81\u78342.17\u4ebf\u7f8e\u91d1\u3002<\/span><\/p>\n


                <\/p>\n

                Akebia\u7684Vadadustat\u5728\u7f8e\u56fd\u548c\u6b27\u76df\u5206\u522b\u4e8e2015\u5e74\u548c2016\u5e74\u8fdb\u5165\u4e86\u201c\u975e\u80be\u900f\u6790\u4f9d\u8d56\u578b\u6162\u6027\u80be\u75c5\u8d2b\u8840\u201d(PRO2TECT\u8bd5\u9a8c)\u548c\u201c\u80be\u900f\u6790\u4f9d\u8d56\u578b\u6162\u6027\u80be\u75c5\u8d2b\u8840\u201d(INNO2VATE)\u7684\u4e34\u5e8a\u9636\u6bb5\uff0c\u9884\u8ba12019\u5e74Akebia\u5c06\u5728\u8fd9\u4e9b\u5730\u533a\u63d0\u4ea4\u4e0a\u5e02\u7533\u8bf7\u3002<\/span><\/p>\n


                <\/p>\n

                Cortellis\u9884\u6d4b\uff0c\u8be5\u836f\u5c06\u4e8e2021\u5e74\u5728\u4ee5\u4e0a\u4e24\u4e2a\u56fd\u5bb6\u548c\u5730\u533a\u83b7\u6279\uff0c\u83b7\u6279\u6210\u529f\u7387\u4e3a85%\u3002\u5728\u65e5\u672c\uff0cVadadustat\u5bf9\u201c\u975e\u80be\u900f\u6790\u4f9d\u8d56\u578b\u6162\u6027\u80be\u75c5\u8d2b\u8840\u201d\u548c\u201c\u975e\u80be\u900f\u6790\u4f9d\u8d56\u578b\u6162\u6027\u80be\u75c5\u8d2b\u8840\u201d\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5206\u522b\u4e8e2017\u5e74\u548c2018\u5e74\u542f\u52a8\u3002Cortellis\u9884\u8ba12021\u5e74\u5728\u65e5\u672c\u83b7\u6279\uff0c\u83b7\u6279\u6210\u529f\u7387\u4e3a86%\u3002\u5e02\u573a\u65b9\u9762\uff0cVadadustat\u7684\u9500\u552e\u989d\u9884\u8ba1\u57282023\u5e74\u8fbe\u52308.5\u4ebf\u7f8e\u91d1\u3002<\/span><\/p>\n


                <\/p>\n<\/section>\n<\/section>\n<\/section>\n

                \n
                \n
                \n

                Roxadustat\u3001Daprodustat \u548cVadadustat\u4e09\u4e2a\u836f\u7269\u7684\u5e02\u573a\u9884\u6d4b<\/span><\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n

                \n
                \n
                \"\u79d1\u777f\u552f\u5b89\u300a\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u9884\u6d4b\u300b2019\u5e74\u5ea6\u62a5\u544a\u5168\u6587\uff08\u4e0a\uff09\"<\/section>\n<\/section>\n
                \n
                Source: Cortellis<\/span><\/section>\n<\/section>\n<\/section>\n<\/section>\n

                \u5176\u4f59\u5185\u5bb9\u8bf7\u53c2\u89c1\u79d1\u777f\u552f\u5b89\u300a\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u9884\u6d4b\u300b2019\u5e74\u5ea6\u62a5\u544a\u5168\u6587\uff08\u4e0b\uff09<\/span>
                <\/p>\n

                <\/span><\/p>\n


                <\/p>\n

                \n
                \n

                \u5f81\u7a3f\u542f\u4e8b<\/a>
                <\/span><\/strong><\/p>\n


                <\/p>\n

                \u540c\u5199\u610f\u8bba\u575b\uff1a<\/span><\/strong><\/p>\n

                \n

                1.\u7b2c91\u671f\u8bba\u575b\u4e28FDA\u4e13\u5bb6\u56e2\u9886\u822a\u65b0\u836f\u4e2d\u7f8e\u53cc\u62a5\u4e4b\u8def<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n


                <\/p>\n

                \"\u79d1\u777f\u552f\u5b89\u300a\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u9884\u6d4b\u300b2019\u5e74\u5ea6\u62a5\u544a\u5168\u6587\uff08\u4e0a\uff09\"<\/span><\/a><\/p>\n


                <\/p>\n

                \u662f\u4e00\u4e2a\u5f00\u653e\uff0c\u7531\u81ea\u613f\u8005\u7ec4\u6210\u7684\u56e2\u4f53\uff0c\u7531\u4ee5\u4e0b\u6210\u5458\u7ec4\u6210\uff1aVoyager88\uff0c\u96f7\u8bfa\u5c9b\uff0cHerman\uff0c\u6885\u5e0c\uff0c\u6587\u7af9\uff0cduke\uff0c\u5360\u5c0f\u5175\uff0c\u9526\u5fc3\u7ee3\u53e3\uff0c\u591a\u5df4\u80fa\uff0c\u745c\u513f\uff0c\u5b50\u708e\uff0c\u514b\u683c\u83ab\uff0cSophia \uff0c\u5076\u9635\u96e8\uff0c\u96f6\u4e0b274\u2103\uff0cHelen\uff0c\u7b49\u7b49\uff0cZMJ\uff0c\u6da6\u513f\uff0c\u4e91\u5377\u3001\u4e8c\u53cb\u6728\u3001\u7f8a\u7f8a\u3001wonger\u3001Jerry\u3001Admiral\u3001\u5723\u624b\u5c0f\u6bd2\u7269\u3001\u9b54\u9b3c\u6df1\u767d\u8272\u3001\u90ed\u5927\u4fa0\u3001\u8427\u6708\u3001\u6c22\u6c14\u53d1\u751f\u5668\u3001\u8c01\u3001\u8d1d\u58f3\u91cc\u7684\u4e7e\u5764\u3001Freesky\u548c\u66fe\u6587\u4eae\u3002\u6b22\u8fce\u6709\u5fd7\u4e4b\u58eb\u52a0\u5165\u6211\u4eec\u56e2\u961f\u3002\u6295\u7a3f\u3001\u5408\u4f5c\u3001\u52a0\u4e13\u4e1a\u7fa4\u8bf7\u52a0\u5fae\u4fe1437180999\uff0c\u4e8c\u5343\u4ebaQQ\u7fa422711855\u3002<\/span><\/p>\n


                <\/p>\n

                \u8d23\u4efb\u7f16\u8f91\uff1a\u96f7\u8bfa\u5c9b<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

                \u672c\u6587\u6765\u6e90\uff1a\u79d1\u777f\u552f\u5b89 \/ \u4e2d\u6587\u7ffb\u8bd1\uff1a\u9a6c\u4e50\u4f1f\uff1b\u8f6c\u8f7d\u5df2\u83b7\u6388\u6743\u3002 \u9884\u8ba12019\u5e74\u8fdb\u5165\u5e02\u573a\u5e76\u5728202 […]<\/p>\n","protected":false},"author":1,"featured_media":83842,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/83841"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=83841"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/83841\/revisions"}],"predecessor-version":[{"id":83854,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/83841\/revisions\/83854"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/83842"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=83841"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=83841"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=83841"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}