{"id":83855,"date":"2019-04-15T00:00:50","date_gmt":"2019-04-17T03:07:55","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/83855\/"},"modified":"2019-04-17T11:07:58","modified_gmt":"2019-04-17T03:07:58","slug":"15cf0ec2b3","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/83855\/","title":{"rendered":"\u79d1\u777f\u552f\u5b89\u300a\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u9884\u6d4b\u300b2019\u5e74\u5ea6\u62a5\u544a\u5168\u6587\uff08\u4e0b\uff09"},"content":{"rendered":"
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\u672c\u6587\u6765\u6e90\uff1a\u79d1\u777f\u552f\u5b89 \/ \u4e2d\u6587\u7ffb\u8bd1\uff1a\u9a6c\u4e50\u4f1f\uff1b<\/span>\u8f6c\u8f7d\u5df2\u83b7\u6388\u6743\u3002<\/span><\/p>\n


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\u9884\u8ba12019\u5e74\u8fdb\u5165\u5e02\u573a\u5e76\u57282023\u5e74\u6210\u4e3a\u201c\u91cd\u78c5\u70b8\u5f39\u201d\u7684\u836f\u7269\u67097\u4e2a\u3002<\/span>\u8fd9\u4e9b\u4ea7\u54c1\u4e3b\u8981\u96c6\u4e2d\u5728\u201c\u514d\u75ab\u201d\u4ee5\u53ca\u201c\u9057\u4f20\u75be\u75c5\u201d\u4e24\u4e2a\u75be\u75c5\u9886\u57df\u3002<\/span>\u4e14\u5927\u90fd\u83b7\u5f97\u4e86\u201c\u5b64\u513f\u836f\u8d44\u683c\u201d\u548c\u201c\u7a81\u7834\u6027\u6cbb\u7597\u5730\u4f4d\u201d\u3002<\/span><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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2019\u5e74\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u4ecb\u7ecd<\/strong><\/p>\n<\/section>\n<\/section>\n

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4. \u9635\u53d1\u6027\u7761\u7720\u6027\u8840\u7ea2\u86cb\u767d\u5c3f\u75c7\u65b0\u836f\uff1aUltomiris<\/p>\n<\/section>\n

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2018\u5e7412\u6708\u83b7FDA\u6279\u51c6\uff0c\u66fe\u83b7\u201c\u5b64\u513f\u836f\u7269\u8d44\u683c\u201d\u3002\u8be5\u836f\u662fAlexion\u91cd\u78c5\u70b8\u5f39\u4ea7\u54c1Soliris\u7684\u4e0b\u4e00\u4ee3\u4ea7\u54c1\uff0c\u6709\u6548\u6027\u65b9\u9762\u975e\u52a3\u6548\u4e8eSoliris\uff0c\u4f46\u987a\u5e94\u6027\u6709\u4e86\u5f88\u5927\u63d0\u5347\uff0c\u5e02\u573a\u6f5c\u529b\u5de8\u5927\u3002<\/span><\/p>\n


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\u9635\u53d1\u6027\u7761\u7720\u6027\u8840\u7ea2\u86cb\u767d\u5c3f\u75c7\uff08PNH\uff09\u662f\u4e00\u79cd\u7f55\u89c1\u7684\u540e\u5929\u6027\u8840\u6db2\u75be\u75c5\uff0c\u6bcf\u767e\u4e07\u4eba\u4e2d\u67091\u81f35\u4eba\u53d1\u75c5\u3002\u7531\u4e8e\u9057\u4f20\u7f3a\u9677\uff0c\u60a3\u8005\u7684\u7ea2\u7ec6\u80de\u5bb9\u6613\u88ab\u4e00\u79cd\u79f0\u4e3a\u8865\u4f53\u7684\u7269\u8d28\u7834\u574f\uff0c\u5bfc\u81f4\u8840\u6813\u7684\u5f62\u6210\uff0c\u8fdb\u800c\u5bfc\u81f4\u6b7b\u4ea1\u6216\u5668\u5b98\u635f\u5bb3\uff0c\u75c7\u72b6\u4e3b\u8981\u5305\u62ec\u547c\u5438\u53ca\u541e\u54bd\u56f0\u96be\u3001\u4e25\u91cd\u8d2b\u8840\u3001\u75b2\u52b3\u3001\u80be\u75c5\u548c\u75bc\u75db\u7b49\u3002<\/p>\n


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Ultomiris<\/span><\/p>\n

Alexion\u7684Ultomiris \u662fPNH \u9886\u57df\u91cd\u78c5\u70b8\u5f39\u4ea7\u54c1Soliris\u7684\u4e0b\u4e00\u4ee3\u4ea7\u54c1\uff0cSoliris\u548cUltomiris\u5747\u4e3a\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\uff0c\u901a\u8fc7\u4e0e\u8865\u4f53C5\u7ed3\u5408\uff0c\u6291\u5236\u5176\u88c2\u89e3\u4e3aC5a\u548cC5b\uff0c\u963b\u65ad\u8865\u4f53\u590d\u5408\u7269C5b-9\u7684\u5f62\u6210\uff0c\u4ece\u800c\u8d77\u5230\u75be\u75c5\u6cbb\u7597\u7684\u4f5c\u7528\u3002\u4e0eSoliris\u6bcf2\u5468\u7ed9\u836f1\u6b21\u76f8\u6bd4\uff0cUltomiris\u6bcf8\u5468\u7ed9\u836f\u4e00\u6b21\uff0c\u987a\u5e94\u6027\u6709\u4e86\u5f88\u5927\u63d0\u9ad8\u3002<\/p>\n


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2018\u5e7412\u6708\uff0cFDA\u6279\u51c6\u8be5\u836f\u7528\u4e8e\u6210\u5e74PNH\u60a3\u8005\u7684\u6cbb\u7597\uff0c\u4ece\u63d0\u4ea4\u4e0a\u5e02\u7533\u8bf7\u5230\u83b7\u6279\uff0cUltomiris\u4ec5\u7528\u4e866\u4e2a\u6708\uff0c\u6bd4FDA\u5b8c\u6210\u4f18\u5148\u5ba1\u8bc4\u7684\u76ee\u6807\u65f6\u95f4\u63d0\u524d\u4e862\u4e2a\u6708\u30022019\u5e741\u6708\uff0c\u8be5\u836f\u5df2\u7ecf\u5728\u7f8e\u56fd\u4e0a\u5e02\u3002\u622a\u6b62\u53d1\u7a3f\u524d\uff0c\u8be5\u836f\u5728\u6b27\u76df\u548c\u65e5\u672c\u5c1a\u5904\u4e8e\u5f85\u6279\u51c6\u72b6\u6001\u3002<\/p>\n


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Ultomiris\u5728\u7f8e\u56fd\u7684\u6279\u51c6\u57fa\u4e8e\u4e24\u4e2aIII\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08301\u548c302\u8bd5\u9a8c\uff09\uff1a<\/p>\n


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    \n
  • \n

    301\u8bd5\u9a8c\u8868\u660e\uff0c\u5728\u672a\u4f7f\u7528\u8865\u4f53\u6291\u5236\u5242\u7684\u60a3\u8005\u4e2d\uff0c\u63a5\u53d7Ultomiris\u6cbb\u7597\u7684\u60a3\u8005\uff0c73.6%\u65e0\u9700\u8f93\u8840\uff0c53.6%\u60a3\u8005\u7684\u4e73\u9178\u8131\u6c22\u9176\u6c34\u5e73\u8fbe\u5230\u6b63\u5e38\u5316\uff08\u4e73\u9178\u8131\u6c22\u9176\u4e3a\u4e00\u79cd\u7ec6\u80de\u635f\u4f24\u548c\u7834\u574f\u7684\u6807\u8bb0\u7269\uff09\u3002<\/p>\n<\/li>\n

  • \n

    302\u8bd5\u9a8c\u8bc1\u5b9e\uff0c\u4eceSoliris\u5207\u6362\u81f3Ultomiris\u65f6\uff0cUltomiris\u975e\u52a3\u6548\u4e8eSoliris\u3002<\/p>\n<\/li>\n<\/ul>\n


    <\/p>\n

    \u9635\u53d1\u6027\u7761\u7720\u6027\u8840\u7ea2\u86cb\u767d\u5c3f\u75c7\u7684\u5e02\u573a
    <\/span><\/p>\n

    2007\u5e74\uff0cFDA\u6279\u51c6Soliris\u7528\u4e8ePNH\u7684\u6cbb\u7597\uff0c\u8be5\u836f\u662f\u7b2c\u4e00\u4e2a\u4e5f\u662f\u76ee\u524d\u552f\u4e00\u4e00\u4e2a\u7528\u4e8ePNH\u7684\u836f\u7269\u3002\u5728\u4e00\u9879\u540d\u4e3aTRIUMPH\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c49%\u7684\u60a3\u8005\u8840\u7ea2\u86cb\u767d\u7a33\u5b9a\uff0c\u800c\u4f7f\u7528\u5b89\u6170\u5242\u60a3\u8005\u7684\u8fd9\u4e00\u6307\u6807\u4e3a0\u3002\u7ed9\u836f\u7ec4\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c\u4e73\u9178\u8131\u6c22\u9176\u4e0b\u964d\u4e8685.8%\u3002\u6765\u81eaTRIUMPH, SHEPHERD\u548cX03-001\u7684\u6570\u636e\u663e\u793a\uff0c\u7ed9\u836f\u7ec4\u8840\u6813\u4e8b\u4ef6\uff08PNH\u60a3\u8005\u6700\u5e38\u89c1\u7684\u6b7b\u4ea1\u539f\u56e0\uff09\u7684\u53d1\u751f\u7387\u51cf\u5c11\u4e8685%\u3002<\/p>\n


    <\/p>\n

    \u5c3d\u7ba1PNH\u662f\u4e00\u79cd\u975e\u5e38\u7f55\u89c1\u7684\u75be\u75c5\uff0c\u4f46Soliris\u5229\u7528\u201c\u5b64\u513f\u836f\u201d\u7684\u5b9a\u4ef7\u4f18\u52bf\u6210\u5c31\u4e86\u5176\u201c\u91cd\u78c5\u70b8\u5f39\u201d\u7684\u8eab\u4efd\u30022017\u5e74\uff0cSoliris\u7684\u9500\u552e\u989d\u9ad8\u8fbe31.4\u4ebf\u7f8e\u91d1\u3002Cortellis\u9884\u6d4b\uff0c\u8be5\u836f2023\u5e74\u7684\u9500\u552e\u989d\u5c06\u7a81\u783437.8\u4ebf\u7f8e\u91d1\u3002Soliris\u7684\u4e0b\u4e00\u4ee3\u4ea7\u54c1Ultomiris\uff0c\u4e34\u5e8a\u6548\u679c\u4e0d\u900aSoliris\uff0c\u800c\u4e14\u60a3\u8005\u987a\u5e94\u6027\u5f97\u5230\u4e86\u5f88\u5927\u7684\u63d0\u9ad8\uff0c\u5e02\u573a\u5360\u6709\u7387\u5c06\u66f4\u6709\u4f18\u52bf\u3002Cortellis\u9884\u6d4b\uff0cUltomiris\u57282023\u5e74\u7684\u9500\u552e\u989d\u5c06\u8fbe\u523019.3\u4ebf\u7f8e\u91d1\u3002\u60a3\u8005\u4eceSoliris\u8f6c\u6362\u4e3aUltomiris\u65f6\uff0cUltomiris\u975e\u52a3\u6548\u4e8e\u524d\u8005\uff0c\u8fd9\u4f7fAlexion\u80fd\u591f\u9f13\u52b1\u60a3\u8005\u4eceSoliris\u5411Ultomiris\u5207\u6362\uff1b\u5c3d\u7ba1\u5176\u4ed6\u516c\u53f8\u5f00\u53d1\u7684Soliris\u7c7b\u4f3c\u7269\u5df2\u7ecf\u5904\u4e8e\u4e34\u5e8a\u540e\u671f\uff0c\u4f46Ultomiris\u51ed\u501f\u5176\u5728\u5728\u7ed9\u836f\u5468\u671f\u53ca\u987a\u5e94\u6027\u65b9\u9762\u7684\u4f18\u52bf\uff0c\u5fc5\u5c06\u5ef6\u7eedSoliris\u7684\u201c\u795e\u8bdd\u201d\u3002\u5728Soliris\u7684\u201c\u9635\u5730\u5b88\u62a4\u6218\u201d\u4e2d\uff0c\u56e0\u4e3a\u6709\u4e86Ultomiris\uff0cAlexion\u4f3c\u4e4e\u5b9e\u73b0\u4e86\u6218\u7565\u6027\u7684\u80dc\u5229\u3002
    <\/p>\n


    <\/p>\n

    Ultomiris\u7684\u7ade\u4e89\u4e3b\u8981\u6765\u81ea\u4e34\u5e8a\u540e\u671f\u7684\u5176\u4ed6\u8865\u4f53\u6291\u5236\u5242\uff0c\u6bd4\u5982Akari\u516c\u53f8\u7684Coversin\u3001Apellis\u7684APL-2\u3001Achilion\u7684Danicopan\uff0c\u4ee5\u53caRa\u5236\u836f\u7684Zilucoplan\u3002<\/p>\n


    <\/p>\n

    2017\u5e743\u6708\uff0cCoversin\u8fdb\u5165PNH\u7684III\u671f\u4e34\u5e8a(AK581\u8bd5\u9a8c)\u30022018\u5e746\u6708\uff0cAPL-2\u8fdb\u5165III\u671f\u4e34\u5e8a(PEGASUS\u8bd5\u9a8c)\u3002Cortellis\u9884\u6d4b\uff0c\u4ee5\u4e0a\u4e24\u79cd\u836f\u7269\u5c06\u57282021\u5e74\u83b7\u6279\uff0c\u83b7\u6279\u7684\u6210\u529f\u7387\u5206\u522b\u4e3a86%\u548c81%\u3002<\/p>\n


    <\/p>\n

    Danicopan\u548cZilucoplan\u76ee\u524d\u5904\u4e8eII\u671f\u4e34\u5e8a\u3002\u636eCortellis\u9884\u6d4b\uff0cDanicopan\u5728\u7f8e\u56fd\u548c\u6b27\u76df\u7684\u83b7\u6279\u65f6\u95f4\u5747\u4e3a2022\u5e74\uff0c\u83b7\u6279\u7684\u6210\u529f\u7387\u5747\u4e3a54%\u3002\u5e02\u573a\u65b9\u9762\uff0c\u9884\u8ba1\u8be5\u836f2023\u5e74\u7684\u9500\u552e\u989d\u4e3a6.09\u4ebf\u7f8e\u91d1\uff1bZilucoplan\u5728\u7f8e\u56fd\u83b7\u6279\u7684\u65f6\u95f4\u540c\u6837\u4e3a2022\u5e74\uff08\u83b7\u6279\u6210\u529f\u7387\u4e3a56%\uff09\uff0c\u5728\u6b27\u76df\u7684\u83b7\u6279\u65f6\u95f4\u4e3a2023\u5e74(\u83b7\u6279\u6210\u529f\u7387\u4e3a62%)\uff0c\u9884\u8ba12023\u5e74Zilucoplan\u7684\u9500\u552e\u989d\u5c06\u7a81\u78341.54\u4ebf\u7f8e\u91d1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

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    <\/p>\n<\/section>\n<\/section>\n<\/section>\n

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    Ultomiris\u3001Soliris\u3001Danicopan\u3001Zilucoplan<\/strong><\/p>\n

    \u56db\u79cd\u836f\u7269\u7684\u5e02\u573a\u9884\u6d4b<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

    \n
    \n
    \"\u79d1\u777f\u552f\u5b89\u300a\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u9884\u6d4b\u300b2019\u5e74\u5ea6\u62a5\u544a\u5168\u6587\uff08\u4e0b\uff09\"<\/section>\n<\/section>\n<\/section>\n
    \n
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    Source:<\/strong> <\/span>Cortellis<\/em>
    <\/p>\n<\/section>\n<\/section>\n<\/section>\n

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    5. \u94f6\u5c51\u75c5\u65b0\u836f\uff1aRisankizumab<\/p>\n<\/section>\n

    <\/section>\n<\/section>\n<\/section>\n
    \n
    \n
    \n

    Risankizumab\u4e0a\u5e02\u540e\uff0c\u5c06\u4e0e\u4f17\u591a\u6cbb\u7597\u624b\u6bb5\u5c55\u5f00\u6fc0\u70c8\u7684\u7ade\u4e89\uff0c\u5982\u5c40\u90e8\u7ed9\u836f\u3001\u5149\u7597\u6cd5\u548c\u7cfb\u7edf\u7597\u6cd5\uff0c\u5305\u62ec\u4f17\u591a\u751f\u7269\u5236\u5242\u53ca\u5176\u751f\u7269\u7c7b\u4f3c\u7269\u3002<\/span><\/p>\n


    <\/p>\n

    \u94f6\u5c51\u75c5\u662f\u4e00\u79cd\u6162\u6027\u708e\u75c7\u6027\u76ae\u80a4\u75c5\u3002\u7531\u4e8e\u76ae\u80a4\u7ec6\u80de\u7684\u975e\u6b63\u5e38\u589e\u957f\uff0c\u7ec6\u80de\u5728\u76ae\u80a4\u8868\u9762\u79ef\u7d2f\uff0c\u5f62\u6210\u5bfc\u81f4\u7619\u75d2\u548c\u75bc\u75db\u7684\u9cde\u7247\u548c\u6591\u5757\u3002\u5b83\u662f\u7531\u514d\u75ab\u7cfb\u7edf\u4e2d\u7684T\u6dcb\u5df4\u7ec6\u80de\u548c\u4e2d\u6027\u7c92\u7ec6\u80de\u653b\u51fb\u5065\u5eb7\u7684\u76ae\u80a4\u7ec6\u80de\u5f15\u53d1\u7684\uff0c\u6df1\u5c42\u6b21\u7684\u4f5c\u7528\u673a\u5236\u76ee\u524d\u5c1a\u4e0d\u660e\u786e\u3002\u8be5\u75be\u75c5\u7684\u53d1\u75c5\u7387\u5728\u5168\u7403\u8303\u56f4\u5185\u5b58\u5728\u8f83\u5927\u5dee\u5f02\uff0c\u5728\u5927\u591a\u6570\u53d1\u8fbe\u56fd\u5bb6\uff0c\u53d1\u75c5\u7387\u57281.5%\u52305%\u4e4b\u95f4\u3002
    <\/p>\n


    <\/p>\n

    Risankizumab<\/span><\/p>\n

    Risankizumab\u662f\u7531\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\u548c\u827e\u4f2f\u7ef4\u8054\u5408\u5f00\u53d1\u7684\u4e00\u79cd\u5355\u514b\u9686\u6297\u4f53\uff0c\u901a\u8fc7\u6291\u5236\u4fc3\u708e\u7ec6\u80de\u56e0\u5b50IL-23\u8d77\u6548\u3002Risankizumab\u7684\u6301\u6709\u8005\u5206\u522b\u4e8e2018\u5e744\u6708\u548c5\u6708\u5411\u7f8e\u56fd\u548c\u6b27\u76df\u3001\u65e5\u672c\u9012\u4ea4\u4e86\u8be5\u836f\u7528\u4e8e\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u6591\u5757\u578b\u94f6\u5c51\u75c5\u7684\u4e0a\u5e02\u7533\u8bf7\u3002\u4e5f\u662f\u57282018\u5e745\u6708\uff0c\u5411\u65e5\u672c\u9012\u4ea4\u4e86\u8be5\u836f\u7528\u4e8e\u6591\u5757\u578b\u94f6\u5c51\u75c5\u3001\u94f6\u5c51\u75c5\u5173\u8282\u708e\u3001\u8113\u75b1\u6027\u94f6\u5c51\u75c5\u548c\u7ea2\u76ae\u75c5\u578b\u94f6\u5c51\u75c5\u7684\u4e0a\u5e02\u7533\u8bf7\u3002Cortellis\u9884\u6d4b\uff0c\u8be5\u836f\u5728\u4ee5\u4e0a\u5730\u533a\u7684\u83b7\u6279\u65f6\u95f4\u4e3a2019\u5e74\u4e0a\u534a\u5e74\uff0c\u83b7\u6279\u7684\u6210\u529f\u7387\u5747\u4e3a95%\u3002\u5e02\u573a\u9884\u6d4b\u65b9\u9762\uff0c\u9884\u8ba12023\u5e74Risankizumab\u7684\u9500\u552e\u989d\u5c06\u7a81\u783417.4\u4ebf\u7f8e\u91d1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

    \n
    \n
    \n


    <\/p>\n<\/section>\n<\/section>\n<\/section>\n

    \n
    \n
    \n

    Risankizumab\u7684\u4e0a\u5e02\u65f6\u95f4\u53ca\u6210\u529f\u7387\u9884\u6d4b<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

    \n
    \n
    \"\u79d1\u777f\u552f\u5b89\u300a\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u9884\u6d4b\u300b2019\u5e74\u5ea6\u62a5\u544a\u5168\u6587\uff08\u4e0b\uff09\"<\/section>\n<\/section>\n<\/section>\n
    \n
    \n
    \n

    Source:<\/strong> <\/span>Cortellis Analytics \u2013 Drug Timeline & Success Rates<\/em>
    <\/p>\n<\/section>\n<\/section>\n<\/section>\n

    \n
    \n
    \n


    <\/p>\n<\/section>\n<\/section>\n<\/section>\n

    \n
    \n
    \n

    Risankizumab\u7684\u4e0a\u5e02\u7533\u8bf7\u57fa\u4e8e\u4ee5\u4e0b4\u4e2a\u5173\u952e\u6027\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff1aULTIMMA-1\u3001ULTIMMA-2\u3001IMMVENT\u548cIMMhance\u3002<\/p>\n


    <\/p>\n

    ULTIMMA-1\u548cULTIMMA-2\u8bd5\u9a8c\u91c7\u7528\u4e86\u9633\u6027\u5bf9\u7167\uff08\u5f3a\u751f\u7684\u540c\u7c7b\u836f\u7269Stelara\uff09\u53ca\u9634\u6027\u5bf9\u7167\uff08\u5b89\u6170\u5242\uff09\u7684\u65b9\u5f0f\u8bc4\u4f30\u4e86Risankizumab\u7684\u6709\u6548\u6027\uff0c\u8bd5\u9a8c\u7684\u4e3b\u8981\u4e34\u5e8a\u7ec8\u70b9\u4e3a\uff1aPASI90\uff08\u94f6\u5c51\u75c5\u76ae\u80a4\u9762\u79ef\u548c\u4e25\u91cd\u7a0b\u5ea6\u6539\u5584\u7387\u4e0d\u5c0f\u4e8e90%\uff09\u548csPGA0\/1\uff08\u9759\u6001\u533b\u5e08\u8bc4\u4f30\u8bc4\u5206\u4e3a\u201c\u6e05\u9664\u201d\u6216\u51e0\u4e4e\u201c\u6e05\u9664\u201d\uff09
    <\/p>\n


    <\/p>\n

    Risankizumab\u5728\u4e24\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8868\u73b0\u5f3a\u52b2\uff1a<\/p>\n

      \n
    • \n

      \u5728ULTIMMA-1\u8bd5\u9a8c\u4e2d\uff0c\u63a5\u53d7Risankizumab\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u670975%\u5728\u7b2c16\u5468\u8fbe\u5230\u4e86PASI90\uff0cRisankizumab\u7ec4\u3001Stelara\u5bf9\u7167\u7ec4\u3001\u5b89\u6170\u5242\u7ec4\u7684 SPGA0\/1\u5206\u522b\u4e3a88%\u300163%\u548c8%\u3002<\/p>\n<\/li>\n

    • \n

      \u5728ULTIMMA-2\u8bd5\u9a8c\u4e2d\uff0c\u4e09\u7ec4PASI90\u7684\u6210\u529f\u7387\u5206\u522b\u4e3a75%\u300148%\u548c2%\uff0csPGA0\/1\u7684\u6210\u529f\u7387\u5206\u522b\u4e3a84%\u300162%\u548c5%\u3002<\/span>
      <\/p>\n<\/li>\n<\/ul>\n


      <\/p>\n

      IMMvent\u8bd5\u9a8c\u5c06Risankizumab\u4e0eHumira\u505a\u4e86\u5934\u5bf9\u5934\u7684\u5bf9\u6bd4\uff0c\u6570\u636e\u663e\u793a\uff1a<\/span><\/p>\n

        \n
      • \n

        \u7b2c16\u5468PASI90\u7684\u8fbe\u6807\u7387\uff1aRisankizumab vs. Humira = 72% vs. 47%\u3002<\/p>\n<\/li>\n

      • \n

        sPGA0\/1\u8fbe\u6807\u7387\uff1aRisankizumab vs. Humira = 84% vs. 60%\u3002<\/p>\n<\/li>\n<\/ul>\n


        <\/p>\n

        \u5c06\u63a5\u53d7Risankizumab\u6cbb\u7597\u4e14\u7b2c28\u5468PASI90\u8fbe\u6807\u7684\u60a3\u8005\u968f\u673a\u5206\u4e3a\u201c\u505c\u836f\u7ec4\u201d\u548c\u201c\u7ef4\u6301\u6cbb\u7597\u7ec4\u201d\uff0c\u505c\u836f\u7ec432\u5468\u4e4b\u540e\u53d1\u4f5c\u7684\u60a3\u8005\u91cd\u65b0\u91c7\u7528Risankizumab\u6cbb\u7597\u3002\u7ed3\u679c\u663e\u793a\uff0c\u7b2c52\u5468sPGA0\/1\u8fbe\u6807\u7387\uff1a\u7ef4\u6301\u6cbb\u7597\u7ec4 vs. \u505c\u836f\u7ec4= 87% vs. 61%\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

        \n
        \n
        \n


        <\/p>\n<\/section>\n<\/section>\n<\/section>\n

        \n
        \n
        \n

        Risankizumab 4\u4e2a\u5173\u952e\u6027\u4e34\u5e8a\u8bd5\u9a8c\u7684<\/strong><\/p>\n

        PASI90\u548csPGA 0\/1\u5bf9\u6bd4\u60c5\u51b5<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

        \n
        \n
        \"\u79d1\u777f\u552f\u5b89\u300a\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u9884\u6d4b\u300b2019\u5e74\u5ea6\u62a5\u544a\u5168\u6587\uff08\u4e0b\uff09\"<\/section>\n<\/section>\n<\/section>\n
        \n
        \n
        \n

        Source:<\/strong> <\/span>Cortellis<\/em>
        <\/p>\n<\/section>\n<\/section>\n<\/section>\n

        \n
        \n
        \n


        <\/p>\n<\/section>\n<\/section>\n<\/section>\n

        \n
        \n
        \n

        \u9002\u5e94\u75c7\u62d3\u5c55\u65b9\u9762\uff0c\u9664\u94f6\u5c51\u75c5\u5916\uff0cRisankizumab\u5728\u94f6\u5c51\u75c5\u5173\u8282\u708e\u3001\u54ee\u5598\u3001\u514b\u7f57\u6069\u75c5\u4ee5\u53ca\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u7b49\u65b9\u9762\u5747\u5f00\u5c55\u4e86\u4e34\u5e8a\u8bd5\u9a8c\u3002\u672a\u6765\uff0c\u8fd9\u4e9b\u9002\u5e94\u75c7\u7684\u83b7\u6279\u5c06\u4e3a\u5176\u5e02\u573a\u7684\u589e\u957f\u63d0\u4f9b\u65b0\u7684\u52a8\u529b\u3002<\/p>\n


        <\/p>\n

        \u94f6\u5c51\u75c5\u5e02\u573a<\/span><\/p>\n

        \u4e34\u5e8a\u4e0a\uff0c\u94f6\u5c51\u75c5\u6709\u591a\u79cd\u6cbb\u7597\u65b9\u5f0f\uff0c\u5982\uff1a\u5c40\u90e8\u6cbb\u7597\u3001\u5149\u7597\u6cd5\u3001\u7cfb\u7edf\u836f\u7269\u6cbb\u7597\u7b49\u3002\u975e\u5904\u65b9\u836f\u4e2d\uff0c\u5e38\u89c1\u6709\u6c34\u6768\u9178\u3001\u7164\u7126\u6cb9\u7b49\uff0c\u8fd9\u4e9b\u836f\u7269\u5177\u6709\u60a0\u4e45\u7684\u94f6\u5c51\u75c5\u6cbb\u7597\u5386\u53f2\uff1b\u5904\u65b9\u836f\u4e2d\uff0c\u76ae\u8d28\u7c7b\u56fa\u9187\uff0c\u7ef4\u7532\u9178\u548c\u7ef4\u751f\u7d20D\u7c7b\u4f3c\u7269\u7b49\u5747\u4e3a\u5e38\u7528\u7684\u5916\u7528\u836f\uff1b\u9664\u6b64\u4e4b\u5916\uff0c\u5149\u7597\u6cd5\u56e0\u5177\u6709\u8f83\u597d\u7684\u5b89\u5168\u6027\u3001\u6709\u6548\u6027\u3001\u6210\u672c\u6548\u76ca\u548c\u8f83\u4f4e\u7684\u7cfb\u7edf\u6bd2\u6027\u548c\u514d\u75ab\u6291\u5236\u4f5c\u7528\uff0c\u76ee\u524d\u4e5f\u5df2\u6210\u4e3a\u6cbb\u7597\u94f6\u5c51\u75c5\u7684\u91cd\u8981\u624b\u6bb5\uff1b\u7cfb\u7edf\u836f\u7269\u6cbb\u7597\u65b9\u9762\uff0c\u7532\u6c28\u8776\u5464\u56e0\u4ef7\u683c\u4f4e\u5ec9\uff0c\u5df2\u7ecf\u6210\u4e3a\u5168\u7403\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u94f6\u5c51\u75c5\u7684\u5e38\u7528\u836f\uff0c\u800c\u6700\u8fd1\u51e0\u5e74\u624d\u8fdb\u5165\u5e02\u573a\u7684\u963f\u666e\u65af\u7279\u5728\u6cbb\u7597\u8f7b\u5ea6\u81f3\u4e2d\u5ea6\u94f6\u5c51\u75c5\u7684\u7597\u6548\u65b9\u9762\u4e5f\u5f00\u59cb\u5d2d\u9732\u5934\u89d2\uff0c\u5176\u7597\u6548\u751a\u81f3\u4f18\u4e8e\u751f\u7269\u836f\u3002<\/p>\n


        <\/p>\n

        \u5728\u94f6\u5c51\u75c5\u751f\u7269\u836f\u6cbb\u7597\u9886\u57df\u3002TNF\u6291\u5236\u5242\u4e2d\u7684Humira\u53caEnbrel\u5360\u7edd\u5bf9\u4e3b\u5bfc\u5730\u4f4d\uff0c\u4f46\u7531\u4e8e\u4ee5\u4e0a\u4e24\u4e2a\u836f\u7269\u7684\u751f\u7269\u7c7b\u4f3c\u7269\u5df2\u7ecf\u4e0a\u5e02\uff0c\u5176\u8f83\u4f4e\u7684\u4ef7\u683c\u5bf9\u54c1\u724c\u836f\u5e02\u573a\u53ef\u80fd\u4f1a\u9020\u6210\u4e0d\u5c0f\u7684\u51b2\u51fb\uff1bIL-23\u6291\u5236\u5242\u5bb6\u65cf\u4e5f\u662f\u8be5\u9886\u57df\u4e0d\u53ef\u5ffd\u89c6\u7684\u53c2\u8d5b\u8005\u3002\u5176\u4e2dIL-12\/IL-23\u6291\u5236\u5242\u7684First-in-Class\u836f\u7269Stelara\u3001IL-23\u6291\u5236\u5242Ilumya\u548cTremfya\u90fd\u662f\u5178\u578b\u4ee3\u8868\u3002\u503c\u5f97\u5f3a\u8c03\u7684\u662f\uff0cIL-17\u6291\u5236\u5242\u4e5f\u662f\u94f6\u5c51\u75c5\u9886\u57df\u7684\u540e\u8d77\u4e4b\u79c0\u3002\u4ece\u4f5c\u7528\u673a\u7406\u4e0a\u6765\u770b\uff0cIL-17\u4e3aTNF\u548cIL-23\u7684\u4e0b\u6e38\u9776\u70b9\uff0c\u5177\u6709\u66f4\u597d\u7684\u7597\u6548\uff0c\u66f4\u5c11\u7684\u4e0d\u826f\u53cd\u5e94\u4ee5\u53ca\u66f4\u5feb\u7684\u8d77\u6548\u901f\u5ea6\uff0c\u8bfa\u534e\u7684Cosentyx\u5728CLEAR\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5c55\u73b0\u51fa\u7684\u6709\u6548\u6027\u4f18\u4e8eStelara\uff0c\u4ece\u4fa7\u9762\u4e5f\u4f53\u73b0\u4e86\u8be5\u9776\u70b9\u7684\u4f18\u8d8a\u6027\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

        \n
        \n
        \n


        <\/p>\n<\/section>\n<\/section>\n<\/section>\n

        \n
        \n
        \n

        Risankizumab\u3001Humira\u3001Enbrel\u3001Stelara\u3001Ilumya\u3001Tremfya\u3001Cosentyx \u4e03\u4e2a\u836f\u7269\u7684\u5e02\u573a\u60c5\u51b5<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

        \n
        \n
        \"\u79d1\u777f\u552f\u5b89\u300a\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u9884\u6d4b\u300b2019\u5e74\u5ea6\u62a5\u544a\u5168\u6587\uff08\u4e0b\uff09\"<\/section>\n<\/section>\n<\/section>\n
        \n
        \n
        \n

        Source:<\/strong> <\/span>Cortellis<\/em>
        <\/p>\n<\/section>\n<\/section>\n<\/section>\n

        \n
        \n
        \n


        <\/p>\n<\/section>\n<\/section>\n<\/section>\n

        \n
        \n
        \n

        6. \u82b1\u751f\u8fc7\u654f\u65b0\u836f\uff1aAR-101<\/p>\n<\/section>\n

        <\/section>\n<\/section>\n<\/section>\n
        \n
        \n
        \n

        \u8be5\u9886\u57df\u7684First-in-Class\uff0c\u66fe\u83b7\u7a81\u7834\u6027\u6cbb\u7597\u8d44\u683c\uff0c\u9884\u8ba1\u4e0a\u5e02\u540e\u4e00\u6bb5\u65f6\u95f4\u5185\u4e0d\u4f1a\u6709\u4e0e\u4e4b\u6297\u8861\u8005\u3002<\/span><\/p>\n


        <\/p>\n

        \u82b1\u751f\u8fc7\u654f\u662f\u6700\u5e38\u89c1\u53ef\u80fd\u5371\u53ca\u751f\u547d\u7684\u98df\u7269\u8fc7\u654f\u4e4b\u4e00\uff0c\u4ec5\u5728\u7f8e\u56fd\u548c\u6b27\u6d32\u5c31\u6709\u5927\u7ea6600\u4e07\u4eba\u53d7\u5f71\u54cd\u3002\u4e0e\u5176\u4ed6\u98df\u7269\u8fc7\u654f\u4e0d\u540c\u7684\u662f\uff0c\u82b1\u751f\u8fc7\u654f\u7684\u4e25\u91cd\u7a0b\u5ea6\u901a\u5e38\u4e0d\u4f1a\u968f\u60a3\u8005\u5e74\u9f84\u7684\u589e\u957f\u800c\u964d\u4f4e\uff0c\u636e\u7edf\u8ba1\uff0c\u5927\u7ea680%\u7684\u82b1\u751f\u8fc7\u654f\u4f1a\u7ec8\u751f\u5b58\u5728\u3002
        <\/p>\n


        <\/p>\n

        \u82b1\u751f\u5b58\u5728\u4e8e\u5404\u79cd\u5404\u6837\u7684\u98df\u7269\u4e2d\uff0c\u5927\u5927\u589e\u52a0\u4e86\u82b1\u751f\u8fc7\u654f\u7684\u53d1\u75c5\u7387\u3002\u6709\u7814\u7a76\u8868\u660e\uff0c\u8d85\u8fc750%\u7684\u60a3\u8005\u57285\u5e74\u5185\u5bf9\u610f\u5916\u7684\u82b1\u751f\u63a5\u89e6\u4ea7\u751f\u8fc7\u8fc7\u654f\u53cd\u5e94\u3002\u800c\u4e0d\u5e78\u7684\u662f\uff0c\u76ee\u524d\u4e34\u5e8a\u4e0a\u8fd8\u6ca1\u6709\u9488\u5bf9\u82b1\u751f\u8fc7\u654f\u7684\u6cbb\u7597\u6027\u836f\u7269\uff0c\u6613\u53d1\u4eba\u7fa4\u80fd\u505a\u7684\u662f\u5c3d\u53ef\u80fd\u907f\u514d\u63a5\u89e6\u82b1\u751f\uff0c\u5982\u4e0d\u5c0f\u5fc3\u4ea7\u751f\u4e86\u8fc7\u654f\u53cd\u5e94\uff0c\u9700\u53ca\u65f6\u6ce8\u5c04\u80be\u4e0a\u817a\u7d20\u3002
        <\/p>\n


        <\/p>\n

        Aimmune\u516c\u53f8\u7684AR-101\u662f\u4e00\u79cd\u53e3\u670d\u836f\u7269\uff0c\u542b\u6709\u4e00\u5b9a\u6570\u91cf\u7684\u82b1\u751f\u86cb\u767d\u3002\u4e3a\u4f7f\u60a3\u8005\u5bf9\u82b1\u751f\u86cb\u767d\u8131\u654f\uff0c\u8bf1\u5bfc\u60a3\u8005\u63d0\u9ad8\u5bf9\u82b1\u751f\u7684\u8010\u53d7\u6027\uff0c\u8be5\u836f\u7684\u7ed9\u836f\u5242\u91cf\u5728\u524d\u51e0\u4e2a\u6708\u5185\u9700\u9010\u6e10\u9012\u589e\uff0c\u5f53\u5242\u91cf\u8fbe\u5230\u4e00\u5b9a\u7a0b\u5ea6\u4e4b\u540e\uff0c\u7ef4\u6301\u7528\u836f\uff0c\u4fdd\u6301\u5bf9\u82b1\u751f\u7684\u8010\u53d7\u6027\u3002
        <\/p>\n


        <\/p>\n

        2018\u5e7412\u6708\uff0c\u57fa\u4e8ePalisade\u3001ARC00\u548cRamses\u4e09\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\uff0cAimmune\u5411FDA\u9012\u4ea4\u4e86AR-101\u7528\u4e8e\u7f13\u89e34\u81f317\u5c81\u513f\u7ae5\u548c\u9752\u5c11\u5e74\u82b1\u751f\u8fc7\u654f\u7684\u4e0a\u5e02\u7533\u8bf7\uff0c\u5e76\u7533\u8bf7\u4e86\u201c\u4f18\u5148\u5ba1\u8bc4\u201d\u3002Aimmune\u9884\u8ba1\u5c06\u4e8e2019\u5e74\u4e0a\u534a\u5e74\u5411\u6b27\u76df\u9012\u4ea4AR-101\u7684\u4e0a\u5e02\u7533\u8bf7\u3002Cortellis\u9884\u6d4b\uff0cAR-101\u5728\u7f8e\u56fd\u7684\u83b7\u6279\u65f6\u95f4\u4e3a2019\u5e7411\u6708\uff0c\u83b7\u6279\u6210\u529f\u7387\u4e3a95%\u3002\u9884\u8ba1\u8be5\u836f\u57282019\u5e74\u4e0a\u534a\u5e74\u5728\u6b27\u76df\u63d0\u4ea4\u4e0a\u5e02\u7533\u8bf7\u3002<\/p>\n


        <\/p>\n

        \u4e3a\u671f1\u5e74\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08Palisade\u8bd5\u9a8c\uff09\u8bc1\u660e\uff1a\u63a5\u53d7\u201c100mg\u6216\u66f4\u5c11\u91cf\u82b1\u751f\u86cb\u767d\uff08\u7ea61\u7c92\u82b1\u751f\u7684\u4e09\u5206\u4e4b\u4e00\uff09 \u201d\u7684\u5242\u91cf\u9650\u5236\u8bd5\u9a8c\u540e\u3002\u5728\u8bf1\u5bfc\u548c\u7ef4\u6301\u5242\u91cf\u540e\uff0c\u5e74\u9f84\u57284\u81f317\u5c81\u7684AR-101\u6613\u611f\u4eba\u7fa4\u4e2d\uff1a<\/p>\n

          \n
        • \n

          600 mg\u82b1\u751f\u86cb\u767d\u7684\u8010\u53d7\u5242\u91cf\u6311\u6218\u8bd5\u9a8c\u4e2d\uff0cAR-101\u7ec4\u4e0e\u5b89\u6170\u5242\u7ec4\u7684\u8fbe\u6807\u7387\u5206\u522b\u4e3a67.2%\u548c4%\u3002<\/p>\n<\/li>\n

        • \n

          1000 mg\u82b1\u751f\u86cb\u767d\u7684\u8010\u53d7\u5242\u91cf\u6311\u6218\u8bd5\u9a8c\u4e2d\uff0cAR-101\u7ec4\u4e0e\u5b89\u6170\u5242\u7ec4\u7684\u8fbe\u6807\u7387\u5206\u522b\u4e3a50.3%\u548c2.4%\u3002<\/p>\n<\/li>\n<\/ul>\n


          <\/p>\n

          \u6b64\u5916\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0cAR-101\u8fd8\u663e\u7740\u51cf\u8f7b\u4e86\u82b1\u751f\u8fc7\u654f\u7684\u75c7\u72b6\u3002<\/p>\n


          <\/p>\n

          \u82b1\u751f\u8fc7\u654f\u5e02\u573a<\/span>
          <\/p>\n

          \u5c3d\u7ba1\uff0c\u8fd1\u5e74\u6765\u7684\u4e00\u4e9b\u7814\u7a76\u8868\u660e\uff0c\u53e3\u670d\u514d\u75ab\u7597\u6cd5\u53ef\u8bf1\u5bfc\u4eba\u4f53\u5bf9\u98df\u7269\u8fc7\u654f\u7684\u8010\u53d7\u6027\uff0c\u4f46\u5373\u5c06\u6210\u4e3a\u8be5\u9886\u57dfFirst-in-Class\u7684AR-101\uff0c\u5e02\u573a\u6f5c\u529b\u4e0d\u5bb9\u5c0f\u89d1\u3002Cortellis\u9884\u8ba1\uff0c2023\u5e74AR-101\u7684\u9500\u552e\u989d\u5c06\u7a81\u783411.7\u4ebf\u7f8e\u91d1\u3002<\/p>\n


          <\/p>\n

          \u5728\u9002\u5e94\u75c7\u62d3\u5c55\u65b9\u9762\uff0cAR-101\u7684\u7b56\u7565\u662f\u62d3\u5c55\u9002\u7528\u4eba\u7fa4\u7684\u5e74\u9f84\u8303\u56f4\u3002Palisade\u8bd5\u9a8c\u5df2\u7ecf\u8bc1\u660e\uff0c\u8be5\u836f\u672a\u5728\u6210\u4eba\u7fa4\u4f53\u4e2d\u80fd\u5c55\u73b0\u663e\u7740\u7684\u6709\u6548\u6027\uff0c\u56e0\u6b64\uff0c\u5411\u4f4e\u5e74\u9f84\u513f\u7ae5\u7fa4\u4f53\u62d3\u5c55\u5c31\u6210\u4e86AR-101\u7684\u5fc5\u7136\u9009\u62e9\uff0c\u8fd9\u4e00\u70b9\uff0c\u4ece2018\u5e7412\u6708\u5f00\u5c55\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u53ef\u89c1\u4e00\u6591\uff08POSEIDON\u8bd5\u9a8c\uff0c\u53d7\u8bd5\u8005\uff1a1\u81f33\u5c81\u7684\u513f\u7ae5\uff09\u3002\u6709\u5206\u6790\u8ba4\u4e3a\uff0c\u8f83\u5c0f\u7684\u513f\u7ae5\u4e4b\u6240\u6709\u66f4\u5bb9\u6613\u7ecf\u53d7\u98df\u7269\u8fc7\u654f\u7684\u98ce\u9669\uff0c\u662f\u56e0\u4e3a\u4e0e\u5e74\u9f84\u8f83\u5927\u7684\u513f\u7ae5\u53ca\u6210\u4eba\u76f8\u6bd4\uff0c\u4ed6\u4eec\u8bc6\u522b\u98df\u7269\u8fc7\u654f\u6e90\u53ca\u5176\u542b\u91cf\u7684\u80fd\u529b\u8f83\u4f4e\u3002\u800c\u4e14\uff0c\u5728\u5e7c\u513f\u56ed\u6216\u5b66\u6821\u671f\u95f4\uff0c\u7236\u6bcd\u65e0\u6cd5\u5bf9\u4ed6\u4eec\u8fdb\u884c\u6709\u6548\u7684\u76d1\u62a4\u3002
          <\/p>\n


          <\/p>\n

          AR-101\u7684\u7ade\u4e89\u4e3b\u8981\u6765\u6e90\u4e8e\u4e24\u65b9\u9762\uff1a<\/span>
          <\/p>\n

          \u4e00\u65b9\u9762\uff0c\u5176\u4ed6\u5904\u4e8e\u7814\u53d1\u9636\u6bb5\u7684\u82b1\u751f\u8131\u654f\u7597\u6cd5\u662fAR-101\u7684\u5fc5\u7136\u7ade\u4e89\u8005\u3002DBV\u79d1\u6280\u516c\u53f8\u7684\u201cViaskin Peanut\u900f\u76ae\u7597\u6cd5\u201d\u662f\u8fd9\u7c7b\u836f\u7269\u7684\u5178\u578b\u4ee3\u8868\u30022018\u5e7410\u6708\uff0cDBV\u79d1\u6280\u516c\u53f8\u5411FDA\u63d0\u4ea4\u4e86\u8be5\u7597\u6cd5\u7528\u4e8e\u6cbb\u75974\u81f311\u5c81\u513f\u7ae5\u82b1\u751f\u8fc7\u654f\u7684\u4e0a\u5e02\u7533\u8bf7\u3002\u4f46FDA\u8ba4\u4e3a\u8be5\u516c\u53f8\u6240\u9012\u4ea4\u7684\u8d44\u6599\u4e2d\uff0c\u751f\u4ea7\u5de5\u827a\u548c\u8d28\u91cf\u63a7\u5236\u6570\u636e\u4e0d\u8db3\u3002\u5728\u4e0eFDA\u8ba8\u8bba\u4e4b\u540e\uff0c\u8be5\u516c\u53f8\u4e8e2018\u5e7412\u6708\u64a4\u56de\u4e86\u8be5\u4e0a\u5e02\u7533\u8bf7\uff0c\u5e76\u542f\u52a8\u4e86\u91cd\u65b0\u9012\u4ea4\u7a0b\u5e8f\u7684\u51c6\u5907\u5de5\u4f5c\u3002Cortellis\u9884\u6d4b\uff0cViaskin Peanut\u83b7\u6279\u6210\u529f\u7387\u4e3a26%\u3002<\/p>\n


          <\/p>\n

          \u53e6\u4e00\u65b9\u9762\uff0c\u53e3\u670d\u514d\u75ab\u7597\u6cd5\u4e5f\u662fAR-101\u7684\u6f5c\u5728\u7ade\u4e89\u5bf9\u624b\uff0c\u5176\u4e2d\u6bd4\u8f83\u77e5\u540d\u7684\u6709ProTA\u516c\u53f8\u7684\u76ca\u751f\u83cc\u548c\u82b1\u751f\u53e3\u670d\u514d\u75ab\u7597\u6cd5(PPOIT)\u548cCamallergy\u516c\u53f8\u7684\u53e3\u670d\u82b1\u751f\u514d\u75ab\u7597\u6cd5(CA-002)\uff0c\u622a\u6b62\u53d1\u7a3f\u524d\uff0c\u8fd9\u4e24\u79cd\u7597\u6cd5\u5747\u5904\u4e8eIII\u671f\u4e34\u5e8a\u51c6\u5907\u9636\u6bb5\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

          \n
          \n
          \n


          <\/p>\n<\/section>\n<\/section>\n<\/section>\n

          \n
          \n
          \n

          AR-101\u5e02\u573a\u9884\u6d4b<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

          \n
          \n
          \"\u79d1\u777f\u552f\u5b89\u300a\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u9884\u6d4b\u300b2019\u5e74\u5ea6\u62a5\u544a\u5168\u6587\uff08\u4e0b\uff09\"<\/section>\n<\/section>\n<\/section>\n
          \n
          \n
          \n

          Source:<\/strong> <\/span>Cortellis<\/em>
          <\/p>\n<\/section>\n<\/section>\n<\/section>\n

          \n
          \n
          \n


          <\/p>\n<\/section>\n<\/section>\n<\/section>\n

          \n
          \n
          \n

          7. \u03b2\u5730\u4e2d\u6d77\u8d2b\u8840\u65b0\u836f\uff1aLentiGlobin<\/p>\n<\/section>\n

          <\/section>\n<\/section>\n<\/section>\n
          \n
          \n
          \n

          \u03b2\u5730\u4e2d\u6d77\u8d2b\u8840\u7f3a\u9677\uff08\u4e00\u79cd\u5bfc\u81f4\u5371\u53ca\u751f\u547d\u7684\u8d2b\u8840\u7684\u8840\u6db2\u75be\u75c5\uff09\u7684\u57fa\u56e0\u6cbb\u7597\u836f\u7269\uff0c\u66fe\u83b7\u5b64\u513f\u836f\u4e0e\u7a81\u7834\u7597\u6cd5\u8d44\u683c\u3002\u5e02\u573a\u4e0a\u552f\u4e00\u76f4\u63a5\u7684\u7ade\u4e89\u662f\u79fb\u690d\uff0c\u4f46\u79fb\u690d\u56e0\u4e3a\u5f02\u4f53\u57fa\u56e0\u7b49\u95ee\u9898\uff0c\u98ce\u9669\u5de8\u5927\u3002<\/span>
          <\/p>\n


          <\/p>\n

          \u03b2\u5730\u4e2d\u6d77\u8d2b\u8840\u662f\u4e00\u79cd\u9057\u4f20\u6027\u75be\u75c5\uff0c\u5b83\u662f\u7531\u03b2\u73e0\u86cb\u767d\uff08\u8840\u7ea2\u86cb\u767d\u590d\u5408\u4f53\u7684\u4e00\u534a\uff09\u51cf\u5c11\u6216\u7f3a\u4e4f\u5bfc\u81f4\u7684\u5a01\u80c1\u751f\u547d\u7684\u8d2b\u8840\u3002\u8d2b\u8840\u5bf9\u4fc3\u7ea2\u7ec6\u80de\u751f\u6210\u7d20\u7684\u523a\u6fc0\u4f5c\u7528\u53c8\u8fdb\u4e00\u6b65\u5bfc\u81f4\u9aa8\u9abc\u7578\u5f62\u7b49\u751f\u957f\u4ee3\u8c22\u5e76\u53d1\u75c7\u3002\u4e25\u91cd\u7684\u03b2\u5730\u4e2d\u6d77\u8d2b\u8840\u60a3\u8005\u53ef\u80fd\u9700\u7ec8\u751f\u5b9a\u671f\u8f93\u8840\uff0c\u5426\u5219\uff0c\u5927\u591a\u6570\u60a3\u8005\u5c06\u6b7b\u4e8e\u5e7c\u513f\u671f\u3002\u7136\u800c\uff0c\u60a3\u8005\u53cd\u590d\u8f93\u8840\u6240\u5bfc\u81f4\u94c1\u8d85\u8f7d\uff0c\u4f1a\u8fdb\u4e00\u6b65\u5bfc\u81f4\u5e7f\u6cdb\u7684\u5668\u5b98\u635f\u5bb3\u3002\u56e0\u6b64\uff0c\u4e34\u5e8a\u4e0a\u5b9a\u671f\u8f93\u8840\u7684\u75c5\u4eba\u53c8\u5fc5\u987b\u8fdb\u4e00\u6b65\u4f7f\u7528\u94c1\u87af\u5408\u7597\u6cd5\u3002\u8be5\u75be\u75c5\u7684\u53d1\u75c5\u7387\u5728\u4e16\u754c\u5404\u5730\u76f8\u5dee\u8f83\u5927\uff0c\u6bcf\u5e74\u5927\u7ea6\u670960000\u540d\u60a3\u513f\u51fa\u751f\u3002
          <\/p>\n


          <\/p>\n

          \u5f02\u57fa\u56e0\u9020\u8840(HSC)\u79fb\u690d\u662f\u6cbb\u7597\u8f93\u8840\u4f9d\u8d56\u578b\u03b2\u5730\u4e2d\u6d77\u8d2b\u8840\u7684\u4e3b\u8981\u6cbb\u7597\u624b\u6bb5\u3002\u7531\u4e8e\u5f02\u57fa\u56e0\u7684\u5bfc\u5165\uff0c\u8be5\u6cbb\u7597\u624b\u6bb5\u98ce\u9669\u5de8\u5927\uff0c\u6bd4\u5982\uff1a\u4e0e\u6cbb\u7597\u76f8\u5173\u7684\u6b7b\u4ea1\u7387\u3001\u611f\u67d3\u3001\u79fb\u690d\u7269\u5931\u8d25\u3001\u5f02\u4f53\u6392\u65a5\u7b49\u3002\u4e34\u5e8a\u4e0a\uff0c\u8be5\u6cbb\u7597\u624b\u6bb5\u901a\u5e38\u9700\u8981\u6350\u732e\u8005\u7684\u4e0e\u60a3\u8005\u7684\u57fa\u56e0\u53ca\u7ec4\u7ec7\u5177\u6709\u9ad8\u5ea6\u5339\u914d\u6027\uff08\u4e00\u822c\u9700\u4f9b\u4f53\u6765\u6e90\u4e8e\u5144\u5f1f\u59d0\u59b9\uff09\u3002<\/p>\n


          <\/p>\n

          \u84dd\u9e1f\u751f\u7269\u516c\u53f8\u7684LentiGlobin\u4e3a\u8be5\u75be\u75c5\u7684\u6cbb\u7597\u63d0\u4f9b\u4e86\u53e6\u4e00\u79cd\u9009\u62e9\u3002\u8be5\u7597\u6cd5\u9996\u5148\u83b7\u53d6\u75c5\u4eba\u7684\u81ea\u8eab\u7ec6\u80de\uff0c\u7ecf\u57fa\u56e0\u6539\u9020\u540e\uff0c\u4f7f\u5176\u80fd\u4ea7\u751f\u529f\u80fd\u6027\u03b2-\u73e0\u86cb\u767d\uff0c\u7136\u540e\u518d\u5c06\u7ecf\u8fc7\u6539\u9020\u7684\u7ec6\u80de\u91cd\u65b0\u5bfc\u5165\u75c5\u4eba\u4f53\u5185\u3002<\/p>\n


          <\/p>\n

          \u03b2-\u73e0\u86cb\u767d\u57fa\u56e0\u6709\u8bb8\u591a\u6f5c\u5728\u7684\u7a81\u53d8\u3002\u5176\u4e2d\uff0c\u4f7f\u03b2-\u73e0\u86cb\u767d\u4ea7\u751f\u51cf\u5c11\u7684\u7a81\u53d8\u88ab\u79f0\u4e3a\u03b2+\uff0c\u963b\u6b62\u57fa\u56e0\u4ea7\u751f\u03b2-\u73e0\u86cb\u767d\u7684\u7a81\u53d8\u88ab\u79f0\u4e3a\u03b20\u3002\u60a3\u8005\u5982\u679c\u662f\u5b8c\u5168\u7684\u03b20\u7a81\u53d8\uff08\u7eaf\u5408\u5b50\u03b20\uff1a\u201c\u03b20\/\u03b20\u201d\uff09\uff0c\u5219\u4f53\u5185\u65e0\u6cd5\u4ea7\u751f\u03b2-\u73e0\u86cb\u767d\u3002<\/p>\n


          <\/p>\n

          \u9488\u5bf9\u8f93\u8840\u4f9d\u8d56\u578b\u03b2\u5730\u4e2d\u6d77\u8d2b\u8840\u60a3\u8005\uff0cLentiGlobin\u7684\u4e0a\u5e02\u7b56\u7565\u662f\u4ee5\u201c\u975e\u03b20\/\u03b20\u201d\u57fa\u56e0\u578b\u4e3a\u7a81\u7834\u53e3\uff08\u5373\u6709\u4e00\u4e9b\u03b2\u73e0\u86cb\u767d\u6b8b\u7559\u7684\u60a3\u8005\uff09\u30022018\u5e7410\u6708\uff0c\u57fa\u4e8eHGB-204\u3001HGB-205\u3001HGB-207\u53caLTF-303\u56db\u4e2a\u5173\u952e\u6027\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\uff0c\u6b27\u76df\u63a5\u53d7\u4e86\u8be5\u836f\u7528\u4e8e\u201c\u975e\u03b20\/\u03b20\u201d\u9752\u5c11\u5e74\u548c\u6210\u4eba\u6cbb\u7597\u7684\u6ce8\u518c\u8d44\u6599\u3002<\/p>\n


          <\/p>\n

          2018\u5e744\u6708\uff0c\u53d1\u8868\u7684\u4e2d\u671f\u6570\u636e\u663e\u793a\uff08\u6570\u636e\u6765\u81eaHGB-204\u548c HGB-205\u4e24\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\uff09\uff1a\u572813\u4f8b\u201c\u975e\u03b20\/\u03b20\u201d\u60a3\u8005\u4e2d\uff0c12\u4f8b\u5df2\u65e0\u9700\u4f9d\u8d56\u5e38\u89c4\u8f93\u8840\uff1b\u4e14\u8ddd\u4e0a\u6b21\u8f93\u8840\u7684\u4e2d\u4f4d\u65f6\u95f4\u95f4\u9694\u4e3a27\u4e2a\u6708\u3002<\/p>\n


          <\/p>\n

          Cortellis\u9884\u6d4b\uff0cLentiGlobin\u5728\u6b27\u76df\u9884\u8ba12019\u5e7411\u6708\u83b7\u6279\uff0c\u83b7\u6279\u6210\u529f\u7387\u4e3a88%\u3002\u5728\u7f8e\u56fd\uff0c\u8be5\u836f\u9884\u8ba12021\u5e742\u6708\u83b7\u6279\uff0c\u83b7\u6279\u6210\u529f\u7387\u4e3a70%\u3002\u5e02\u573a\u65b9\u9762\uff0c\u9884\u8ba12023\u5e74LentiGlobin\u7684\u5e02\u573a\u5c06\u7a81\u783411.2\u4ebf\u7f8e\u91d1\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

          \n
          \n
          \n


          <\/p>\n<\/section>\n<\/section>\n<\/section>\n

          \n
          \n
          \n

          LentiGlobin\u7684\u4e0a\u5e02\u65f6\u95f4\u53ca\u6210\u529f\u7387\u9884\u6d4b<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

          \n
          \n
          \"\u79d1\u777f\u552f\u5b89\u300a\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u9884\u6d4b\u300b2019\u5e74\u5ea6\u62a5\u544a\u5168\u6587\uff08\u4e0b\uff09\"<\/section>\n<\/section>\n<\/section>\n
          \n
          \n
          \n

          Source:<\/strong> <\/span>Cortellis Analytics \u2013 Drug Timeline & Success Rates<\/em>
          <\/p>\n<\/section>\n<\/section>\n<\/section>\n

          \n
          \n
          \n


          <\/p>\n<\/section>\n<\/section>\n<\/section>\n

          \n
          \n
          \n

          \u03b2\u5730\u4e2d\u6d77\u8d2b\u8840\u5e02\u573a<\/span><\/p>\n

          \u03b2\u5730\u4e2d\u6d77\u8d2b\u8840\uff0c\u662f\u4e00\u4e2a\u4e34\u5e8a\u9700\u6c42\u9ad8\u5ea6\u672a\u6ee1\u8db3\u7684\u75be\u75c5\u9886\u57df\u3002\u76ee\u524d\uff0c\u4e34\u5e8a\u4e0a\u552f\u4e00\u6cbb\u7597\u624b\u6bb5\u662f\u79fb\u690d\uff0c\u4f46\u8be5\u6cbb\u7597\u65b9\u5f0f\u4e24\u4e2a\u4e3b\u8981\u7f3a\u9677\u975e\u5e38\u660e\u663e\uff1a<\/p>\n

            \n
          • \n

            \u6350\u732e\u8005\u7684\u5c40\u9650\u6027\uff1b<\/p>\n<\/li>\n

          • \n

            \u5f02\u4f53\u57fa\u56e0\u7ec6\u80de\u5bfc\u81f4\u7684\u98ce\u9669\u3002<\/p>\n<\/li>\n<\/ul>\n


            <\/p>\n

            LentiGlobin\u83b7\u6279\u7684\u9002\u5e94\u75c7\u8303\u56f4\u8d8a\u5e7f\uff0c\u672a\u6765\u7684\u5e02\u573a\u673a\u4f1a\u5c31\u8d8a\u5927\u3002\u5c3d\u7ba1LentiGlobin\u7684\u6301\u6709\u8005\u6700\u521d\u4ec5\u63d0\u4ea4\u4e86\u8be5\u836f\u7528\u4e8e\u201c\u975e\u03b20\/\u03b20\u201d\u57fa\u56e0\u578b\u6210\u4eba\u548c\u9752\u5c11\u5e74\u6cbb\u7597\u7684\u4e0a\u5e02\u7533\u8bf7\uff0c\u4f46\u9488\u5bf9\u201c\u03b20\/\u03b20\u201d \u57fa\u56e0\u578b\u60a3\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e5f\u5728\u8fdb\u884c\u4e2d\u30022018\u5e744\u6708\u516c\u5e03\u7684\u4e2d\u671f\u6570\u636e\uff08\u57fa\u4e8eHGB-204\u548cHGB-205\u4e24\u4e2a\u8bd5\u9a8c\uff09\u663e\u793a\uff1a9\u540d\u201c\u03b20\/\u03b20\u201d\u57fa\u56e0\u578b\u60a3\u8005\u7684\u5e73\u5747\u8f93\u8840\u91cf\u51cf\u5c11\u4e8673%\uff0c\u67092\u4f4d\u75c5\u4eba\u65e0\u9700\u8f93\u8840\u3002\u9664\u6b64\u4e4b\u5916\uff0c2017\u5e747\u6708\u5f00\u59cb\u7684HGB-212\u8bd5\u9a8c\uff08III\u671f\uff09\u4e5f\u5728\u6709\u6761\u4e0d\u7d0a\u7684\u8fdb\u884c\u4e2d\u3002\u8fd9\u4e9b\u4e34\u5e8a\u8bd5\u9a8c\u6240\u79ef\u7d2f\u7684\u6570\u636e\uff0c\u90fd\u5c06\u662fLentiGlobin\u7684\u9002\u5e94\u75c7\u4e0d\u65ad\u5411\u201c\u03b20\/\u03b20\u201d \u57fa\u56e0\u578b\u03b2\u5730\u4e2d\u6d77\u8d2b\u8840\u62d3\u5c55\u7684\u5f3a\u6709\u529b\u57fa\u7840\u3002<\/p>\n


            <\/p>\n

            \u7ade\u4e89\u65b9\u9762\uff0c\u4e0eLentiGlobin\u4f5c\u7528\u673a\u5236\u76f8\u540c\u7684\u836f\u7269\uff0c\u76ee\u524d\u5747\u843d\u540e\u4e8eLentiGlobin\u3002\u5176\u4e2d\u6700\u8457\u540d\u7684\u5f53\u5c5eOrchard\u7684OTL-300\uff0c\u8be5\u836f\u76ee\u524d\u5904\u4e8eII\u671f\u4e34\u5e8a\uff08TIGET-BTHAL\u8bd5\u9a8c\uff09\u3002Cortellis\u9884\u6d4b\uff0cOTL-300\u9884\u8ba12023\u5e74\u5728\u6b27\u76df\u83b7\u6279\uff0c\u83b7\u6279\u6210\u529f\u7387\u4e3a70%\u3002<\/p>\n


            <\/p>\n

            \u9664\u201c\u03b2-\u73e0\u86cb\u767d\u57fa\u56e0\u4fee\u590d\u201d\u5916\uff0c\u5176\u4ed6\u4f5c\u7528\u673a\u5236\u7684\u8f6c\u57fa\u56e0\u7597\u6cd5\u4e5f\u662fLentiGlobin\u7684\u6f5c\u5728\u7ade\u4e89\u5bf9\u624b\u3002\u6bd4\u5982\u201cBCL11A\u57fa\u56e0\u6539\u9020\u201d\uff0c\u901a\u8fc7\u6539\u9020\u8be5\u57fa\u56e0\u4f7fBCL11A\u57fa\u56e0\u6291\u5236\u4f5c\u7528\u89e3\u9664\u540e\uff0c\u03b2-\u5730\u4e2d\u6d77\u8d2b\u8840\u6216\u8005\u9570\u72b6\u7ec6\u80de\u8d2b\u8840\u60a3\u8005\u5c31\u80fd\u591f\u81ea\u4e3b\u751f\u6210\u8db3\u591f\u7684\u8840\u7ea2\u86cb\u767d\u3002Vertex\u548cCRISPR\u8054\u5408\u5f00\u53d1\u7684CTX-001\u5c31\u662f\u5178\u578b\u4ee3\u8868\uff0c\u8be5\u836f\u76ee\u524d\u5f00\u5c55\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e3b\u8981\u96c6\u4e2d\u5728\u4e24\u4e2a\u9002\u5e94\u75c7\u4e0a\uff1a\u201c\u03b2\u5730\u4e2d\u6d77\u8d2b\u8840\u201d\uff08CTX001-111\uff1a2018\u5e747\u6708\u542f\u52a8\uff09\u548c\u201c\u9570\u72b6\u7ec6\u80de\u75c5\u201d\uff08CTX001-121\uff1a2018\u5e7411\u6708\u542f\u52a8\uff09\uff0c\u76ee\u524d\u4e24\u4e2a\u8bd5\u9a8c\u5747\u5904\u4e8eI\/II\u671f\u4e34\u5e8a\u3002\u65e0\u72ec\u6709\u5076\uff0cSangamo\u548cBioverativ\u7684ST-400\u4e5f\u5df2\u7ecf\u4e8e2018\u5e745\u6708\u8fdb\u5165\u03b2\u5730\u4e2d\u6d77\u8d2b\u8840\u7684I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08ST-400-01\uff09\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

            \n
            \n
            \n


            <\/p>\n<\/section>\n<\/section>\n<\/section>\n

            \n
            \n
            \n

            LentiGlobin\u5e02\u573a\u9884\u6d4b<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n

            \n
            \n
            \"\u79d1\u777f\u552f\u5b89\u300a\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u9884\u6d4b\u300b2019\u5e74\u5ea6\u62a5\u544a\u5168\u6587\uff08\u4e0b\uff09\"<\/section>\n<\/section>\n<\/section>\n
            \n
            \n
            \n

            Source:<\/strong> <\/span>Cortellis<\/em>
            <\/p>\n<\/section>\n<\/section>\n<\/section>\n

            \n
            \n
            \n


            <\/p>\n<\/section>\n<\/section>\n<\/section>\n

            \n
            \n
            \n
            <\/section>\n<\/section>\n
            \n
            <\/section>\n<\/section>\n
            \n
            <\/section>\n<\/section>\n
            \n
            \n
            \n
            \n

            2018\u5e74\u6700\u503c\u7684\u5173\u6ce8\u7684\u836f\u7269\uff0c\u5f53\u524d\u5904\u4e8e\u4ec0\u4e48\u72b6\u6001\uff1f<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

            \n
            <\/section>\n<\/section>\n
            \n
            <\/section>\n<\/section>\n
            \n
            <\/section>\n<\/section>\n<\/section>\n<\/section>\n
            \n
            \n
            \n

            2018\u5e74\u521d\uff0cCortellis\u5206\u6790\u5e08\u9884\u6d4b2018\u5e74\u6700\u503c\u7684\u5173\u6ce8\u7684\u65b0\u836f\u670912\u4e2a\uff0c\u8fd9\u4e9b\u836f\u7269\u5c06\u57282018\u5e74\u8fdb\u5165\u5e02\u573a\uff0c\u5e76\u57282022\u5e74\u6210\u4e3a\u201c\u91cd\u78c5\u70b8\u5f39\u201d\u3002\u6b63\u5982\u9884\u6d4b\u7684\u90a3\u6837\uff0c\u622a\u81f3\u76ee\u524d\uff0c\u8fd912\u79cd\u836f\u7269\u5df2\u5168\u90e8\u4e0a\u5e02\u3002\u4ece\u76ee\u524d\u7684\u9500\u552e\u9884\u6d4b\u6765\u770b\uff0c\u96641\u79cd\u836f\u7269\u5916\uff0c\u5176\u4ed611\u79cd\u836f\u7269\u57282022\u5e74\u7684\u9500\u552e\u9884\u671f\u4ecd\u7136\u662f\u201c\u91cd\u78c5\u70b8\u5f39\u201d\u7ea7\u522b\u3002<\/span><\/p>\n


            <\/p>\n

            Gilead\u7684\u6297\u827e\u6ecb\u75c5\u6bd2\u836f\u7269Biktarvy\uff08\u6bd4\u514b\u4ed6\u97e6+\u6069\u66f2\u4ed6\u6ee8+\u5bcc\u9a6c\u9178\u66ff\u8bfa\u798f\u97e6\uff09\uff0c\u5176\u9500\u552e\u9884\u6d4b\u5728\u300a2018\u5e74\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u300b\u4e2d\u4f4d\u5217\u524d\u8305\u3002\u8be5\u836f\u7269\u5df2\u4e8e2018\u5e742\u6708\u5728\u7f8e\u56fd\u4e0a\u5e02\uff0c2018\u5e746\u6708\u5728\u6b27\u76df\u83b7\u6279\uff0c2018\u5e747\u6708\u5728\u4e00\u4e9b\u6b27\u76df\u56fd\u5bb6\u4e0a\u5e02\uff0c2018\u5e7412\u6708\u53c8\u5728\u65e5\u672c\u83b7\u6279\u3002\u8be5\u836f\u7684\u4e0a\u5e02\u6539\u53d8\u4e86\u5168\u7403\u827e\u6ecb\u75c5\u6cbb\u7597\u7684\u683c\u5c40\u30022018\u5e7410\u6708\uff0c\u7f8e\u56fd\u548c\u6b27\u6d32\u827e\u6ecb\u75c5\u6bd2\u6cbb\u7597\u6307\u5357\u5c06Biktarvy\u5217\u4e3aHIV\u7684\u4e00\u7ebf\u7528\u836f\uff0c\u6781\u5927\u5730\u589e\u52a0\u4e86\u8be5\u836f\u7684\u5e02\u573a\u6f5c\u529b\u3002Cortellis\u9884\u6d4b\uff0c\u8be5\u836f2022\u5e74\u7684\u9500\u552e\u989d\u4e3a56.8\u4ebf\u7f8e\u91d1\uff08\u53bb\u5e74\u540c\u671f\u7684\u9884\u6d4b\u4e3a37.2\u4ebf\u7f8e\u91d1\uff09\u3002Gilead\u671f\u671b\u8be5\u836f\u5728\u5168\u7403\u6210\u4e3a\u5bf9\u6297\u827e\u6ecb\u75c5\u6bd2\u7684\u9996\u9009\u65b9\u6848\uff0c\u5e2e\u52a9\u516c\u53f8\u5de9\u56fa\u5176\u5728\u6297\u75c5\u6bd2\u5e02\u573a\u4e0a\u7684\u5168\u7403\u9886\u5148\u5730\u4f4d\uff0c\u5e76\u671f\u671b\u8be5\u836f\u6210\u4e3a\u4eba\u7c7b\u5386\u53f2\u4e0a\u6700\u6210\u529f\u6297HIV\u836f\u7269\u3002<\/p>\n


            <\/p>\n

            \u622a\u81f3\u300a2018\u5e74\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u300b\u53d1\u8868\u65f6\uff0cRoche\u53caChugai\u516c\u53f8\u8054\u5408\u5f00\u53d1\u7684Hemlibra\u5df2\u8fdb\u5165\u7f8e\u56fd\u7532\u578b\u8840\u53cb\u75c5\u5e02\u573a\uff0c\u7528\u4e8e\u201c\u6709VIII\u56e0\u5b50\u6291\u5236\u5242\u7269\u7684\u7532\u578b\u8840\u53cb\u75c5\u201d\u7684\u6cbb\u7597\uff0c\u5e76\u4e00\u4e3e\u6210\u4e3a\u8be5\u9886\u57df\u8fd120\u5e74\u6765\u7b2c\u4e00\u4e2a\u83b7\u6279\u7684\u65b0\u836f\u30022018\u5e7410\u6708\uff0cHemLibra\u53c8\u83b7FDA\u7684\u989d\u5916\u6279\u51c6\uff0c\u7528\u4e8e\u201c\u65e0VIII\u56e0\u5b50\u6291\u5236\u5242\u7269\u7684\u7532\u578b\u8840\u53cb\u75c5\u201d\u7684\u6cbb\u7597\uff0c\u5e02\u573a\u6f5c\u529b\u8fdb\u4e00\u6b65\u63d0\u5347\u30022018\u5e742\u6708\uff0c\u6b27\u76df\u6279\u51c6\u4e86\u8be5\u836f\u7528\u4e8e\u201c\u6709VIII\u56e0\u5b50\u6291\u5236\u5242\u7269\u7684\u7532\u578b\u8840\u53cb\u75c5\u201d\u7684\u4e0a\u5e02\u7533\u8bf7\u30023\u4e2a\u6708\u540e\uff0c\u8be5\u836f\u5728\u65e5\u672c\u83b7\u6279\u3002Cortellis\u9884\u6d4b\uff0c\u8be5\u836f2022\u5e74\u7684\u9500\u552e\u989d\u5c06\u7a81\u7834 27.5\u4ebf\u7f8e\u91d1\u3002<\/p>\n


            <\/p>\n

            2018\u5e74\u521d\uff0cCortellis\u56e2\u961f\u9884\u6d4b\u8bfa\u548c\u8bfa\u5fb7\u7684Ozempic\uff08\u7d22\u9a6c\u9c81\u80bd\uff09\u57282022\u5e74\u7684\u9500\u552e\u989d\u5c06\u8d85\u8fc730\u4ebf\u7f8e\u91d1\u3002\u65f6\u9694\u4e00\u5e74\uff0c\u8be5\u9500\u552e\u9884\u6d4b\u7ef4\u6301\u4e0d\u53d8\u30022018\u5e742\u6708\uff0cOzempic\u5728\u7f8e\u56fd\u548c\u6b27\u76df\u83b7\u6279\uff0c\u540c\u5e745\u6708\u5728\u65e5\u672c\u83b7\u6279\u3002<\/p>\n


            <\/p>\n

            \u300a2018\u5e74\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u300b\u4e2d\uff0cErleada\u662f\u9996\u4e2a\u83b7FDA\u6279\u51c6\u7684\u7528\u4e8e\u975e\u8f6c\u79fb\u6027\u53bb\u52bf\u6027\u524d\u5217\u817a\u764c\u836f\u7269\uff0c\u8be5\u836f\u4e8e2018\u5e742\u6708\u5728\u7f8e\u56fd\u83b7\u6279\uff0c\u9884\u8ba12022\u5e74\u7684\u9500\u552e\u989d\u4e3a15.8\u4ebf\u7f8e\u5143\u3002\u6b64\u5916\uff0c\u8be5\u836f\u5728\u6b27\u76df\u53ca\u65e5\u672c\u7684\u4e0a\u5e02\u7533\u8bf7\u5206\u522b\u4e8e2018\u5e742\u6708\u548c 5\u6708\u9012\u4ea4\u3002<\/p>\n


            <\/p>\n

            2017\u5e7412\u6708\uff0cGSK\u5f00\u59cb\u5411\u5176\u5206\u9500\u5546\u4f9b\u5e94\u5e26\u72b6\u75b1\u75b9\u75ab\u82d7Shingrix\u30022018\u5e743\u6708\uff0c\u8be5\u836f\u7269\u5728\u6b27\u76df\u548c\u65e5\u672c\u83b7\u6279\u3002Shingrix\u6709\u671b\u6210\u4e3a\u5168\u7403\u5e26\u72b6\u75b1\u75b9\u75ab\u82d7\u9886\u57df\u7684\u9886\u5bfc\u54c1\u724c\u3002<\/p>\n


            <\/p>\n

            \u5bf9\u4e8e\u7f55\u89c1\u75c5\u201c\u9057\u4f20\u6027\u8f6c\u7532\u72b6\u817a\u7d20\u86cb\u767d\u6dc0\u7c89\u6837\u53d8\u6027\u201d\uff0c\u8be5\u9886\u57df\u7684Best-in-Class \u836f\u7269Patisiran\u5df2\u7ecf\u6309\u8ba1\u5212\u4e8e2018\u5e748\u6708\u548c9\u6708\u5206\u522b\u5728\u7f8e\u56fd\u548c\u65e5\u672c\u83b7\u6279\uff0c\u5e76\u4e8e2018\u5e7410\u6708\u767b\u9646\u6b27\u76df\u5e02\u573a\u3002<\/p>\n


            <\/p>\n

            GW\u5236\u836f\u7684Epidiolex\uff08\u690d\u7269\u63d0\u53d6\u7684\u5927\u9ebb\u4e8c\u915a\uff09\u4e8e2018\u5e7411\u6708\u767b\u9646\u7f8e\u56fd\u5e02\u573a\uff0c\u7528\u4e8e\u4f34\u6709Lennox-Gastaut\u6216Dravet\u7efc\u5408\u5f81\u7684\u766b\u75eb\u6cbb\u7597\uff0c\u4e5f\u662f\u5168\u7403\u9996\u4e2a\u542b\u5927\u9ebb\u4e8c\u915a\u7684\u6297\u766b\u75eb\u836f\u30022018\u5e742\u6708\uff0cGW\u5236\u836f\u5411\u6b27\u76df\u9012\u4ea4\u4e86\u8be5\u836f\u7684\u4e0a\u5e02\u7533\u8bf7\u3002<\/p>\n


            <\/p>\n

            \u5728\u504f\u5934\u75db\u9884\u9632\u9886\u57df\uff0cAmgen\u548cNovartis\u8054\u5408\u5f00\u53d1\u7684 Aimovg\u662f\u8be5\u9886\u57df\u7b2c\u4e00\u4e2a\u83b7\u6279\u7684\u65b0\u836f\uff0c\u8be5\u836f\u5df2\u5206\u522b\u4e8e2018\u5e745\u6708\u548c10\u6708\u5728\u7f8e\u56fd\u548c\u6b27\u76df\u4e0a\u5e02\u3002<\/p>\n


            <\/p>\n

            \u5728\u9057\u4f20\u6027\u8840\u7ba1\u6c34\u80bf\u65b9\u9762\uff0c\u4f5c\u4e3a\u987a\u5e94\u6027\u66f4\u597d\u7684\u65b0\u4e00\u4ee3\u6cbb\u7597\u836f\u7269\uff0cShire\u516c\u53f8\u7684Takhzyro\u5206\u522b\u4e8e2018\u5e748\u6708\u548c11\u6708\u83b7FDA\u6279\u51c6\u548c\u6b27\u76df\u6279\u51c6\u3002Cortellis\u5206\u6790\u5e08\u8ba4\u4e3a\uff0c\u8be5\u836f\u5728\u672a\u6765\u5c06\u4e3b\u5bfc\u9057\u4f20\u6027\u8840\u7ba1\u6c34\u80bf\u7684\u5168\u7403\u5e02\u573a\u3002<\/p>\n


            <\/p>\n

            \u75bc\u75db\u6027\u5b50\u5bab\u5185\u819c\u5f02\u4f4d\u75c7\u7684First-in-Class \u836f\u7269Orilissa\u5df2\u7ecf\u4e8e2018\u5e748\u6708\u767b\u9646\u7f8e\u56fd\u5e02\u573a\u3002<\/p>\n


            <\/p>\n

            Pfizer\u548cMerck\u8054\u5408\u5f00\u53d1\u7684II\u578b\u7cd6\u5c3f\u75c5\u836f\u7269 Steglatro \uff08\u57c3\u683c\u5217\u51c0\uff09\u4e8e2018\u5e741\u6708\u767b\u9646\u7f8e\u56fd\u5e02\u573a\uff0c\u5e76\u4e8e2018\u5e743\u6708\u83b7\u6b27\u76df\u6279\u51c6\u3002<\/p>\n


            <\/p>\n

            \u963f\u7247\u4f9d\u8d56\u8f85\u52a9\u8131\u763e\u9886\u57df\uff0cIndivior\u516c\u53f8\u7684Sublocade\u4e8e2018\u5e743\u6708\u5728\u7f8e\u56fd\u4e0a\u5e02\uff0c\u6210\u4e86\u8be5\u9886\u57df\u540d\u526f\u5176\u5b9e\u7684\u9996\u6b3e\u6bcf\u6708\u53ea\u9700\u7ed9\u836f\u4e00\u6b21\u7684\u4e01\u4e19\u8bfa\u5561\u6ce8\u5c04\u5242.Cortellis\u5206\u6790\u5e08\u8ba4\u4e3a\uff0c\u8be5\u836f\u7684\u4e0a\u5e02\u5c06\u7ed9\u201c\u836f\u7269\u8f85\u52a9\u8131\u763e\u6cbb\u7597\u201d \u9886\u57df\u5e26\u6765\u7ffb\u5929\u8986\u5730\u7684\u53d8\u5316\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n

            \n
            \n
            \n


            <\/p>\n<\/section>\n<\/section>\n<\/section>\n

            \n
            \n
            \n
            <\/section>\n<\/section>\n
            \n
            <\/section>\n<\/section>\n
            \n
            <\/section>\n<\/section>\n
            \n
            \n
            \n
            \n

            \u5c55\u671b<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

            \n
            <\/section>\n<\/section>\n
            \n
            <\/section>\n<\/section>\n
            \n
            <\/section>\n<\/section>\n<\/section>\n<\/section>\n
            \n
            \n
            \n

            \u6211\u4eec\u53bb\u5e74\u63a8\u51fa\u4e86\u300a2018\u5e74\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u300b\uff0c\u8fd9\u4e9b\u836f\u7269\u6b63\u5728\u5404\u4e2a\u6cbb\u7597\u9886\u57df\u4ea7\u751f\u7740\u91cd\u5927\u7684\u5f71\u54cd\uff0c\u201c2019\u5e74\u6700\u503c\u7684\u5173\u6ce8\u76847\u79cd\u65b0\u836f\u201d\u6db5\u76d6\u7684\u836f\u7269\u79cd\u7c7b\u5e7f\u6cdb\uff0c\u5e76\u4ee5\u201c\u57fa\u56e0\u4fee\u9970\u201d\u548c\u201c\u514d\u75ab\u8c03\u8282\u201d\u7b49\u4e3a\u4e3b\u9898\uff0c\u8fd9\u4e9b\u5148\u8fdb\u7684\u6cbb\u7597\u6280\u672f\uff0c\u9010\u6e10\u4ece\u6982\u5ff5\u8bbe\u8ba1\u8d70\u5411\u4e34\u5e8a\u4f7f\u7528\uff0c\u4ece\u4fa7\u9762\u8bc1\u660e\u4e86\u8fd1\u51e0\u5341\u5e74\u6765\u4eba\u7c7b\u5728\u751f\u547d\u79d1\u5b66\u9886\u57df\u7684\u60ca\u4eba\u8fdb\u6b65\uff0c\u4e5f\u5c55\u73b0\u4e86\u79d1\u5b66\u7684\u8ff7\u4eba\u5149\u5f69\u3002<\/p>\n

             <\/span><\/p>\n

            \u8bf4\u660e\uff1a<\/span><\/p>\n

            \u672c\u62a5\u544a\u4e2d\u7684\u6570\u636e\u548c\u5206\u6790\u6e90\u81eaCortellis\u6570\u636e\u5e93\uff0cCortellis\u662f\u6765\u81ea\u79d1\u777f\u552f\u5b89\u751f\u547d\u4e0e\u79d1\u5b66\u7684\u667a\u80fd\u89e3\u51b3\u65b9\u6848\u3002\u5305\u62ecCortellis\u7ade\u4e89\u60c5\u62a5\u3001Cortellis\u4ea4\u6613\u60c5\u62a5\u3001Cortellis\u76d1\u7ba1\u60c5\u62a5\u3001Cortellis\u4e34\u5e8a\u8bd5\u9a8c\u60c5\u62a5\u548cCortellis\u4e0a\u5e02\u65f6\u95f4\u548c\u6210\u529f\u7387\u9884\u6d4b\u3002<\/p>\n


            <\/p>\n<\/section>\n<\/section>\n<\/section>\n

            —-END—-<\/span><\/p>\n


            <\/p>\n

            \n
            \n

            \u5f81\u7a3f\u542f\u4e8b<\/a>
            <\/span><\/strong><\/p>\n


            <\/p>\n

            \u540c\u5199\u610f\u8bba\u575b\uff1a<\/span><\/strong><\/p>\n

            \n

            1.\u7b2c91\u671f\u8bba\u575b\u4e28FDA\u4e13\u5bb6\u56e2\u9886\u822a\u65b0\u836f\u4e2d\u7f8e\u53cc\u62a5\u4e4b\u8def<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n


            <\/p>\n

            \"\u79d1\u777f\u552f\u5b89\u300a\u6700\u503c\u5f97\u5173\u6ce8\u7684\u836f\u7269\u9884\u6d4b\u300b2019\u5e74\u5ea6\u62a5\u544a\u5168\u6587\uff08\u4e0b\uff09\"<\/span><\/a><\/p>\n


            <\/p>\n

            \u662f\u4e00\u4e2a\u5f00\u653e\uff0c\u7531\u81ea\u613f\u8005\u7ec4\u6210\u7684\u56e2\u4f53\uff0c\u7531\u4ee5\u4e0b\u6210\u5458\u7ec4\u6210\uff1aVoyager88\uff0c\u96f7\u8bfa\u5c9b\uff0cHerman\uff0c\u6885\u5e0c\uff0c\u6587\u7af9\uff0cduke\uff0c\u5360\u5c0f\u5175\uff0c\u9526\u5fc3\u7ee3\u53e3\uff0c\u591a\u5df4\u80fa\uff0c\u745c\u513f\uff0c\u5b50\u708e\uff0c\u514b\u683c\u83ab\uff0cSophia \uff0c\u5076\u9635\u96e8\uff0c\u96f6\u4e0b274\u2103\uff0cHelen\uff0c\u7b49\u7b49\uff0cZMJ\uff0c\u6da6\u513f\uff0c\u4e91\u5377\u3001\u4e8c\u53cb\u6728\u3001\u7f8a\u7f8a\u3001wonger\u3001Jerry\u3001Admiral\u3001\u5723\u624b\u5c0f\u6bd2\u7269\u3001\u9b54\u9b3c\u6df1\u767d\u8272\u3001\u90ed\u5927\u4fa0\u3001\u8427\u6708\u3001\u6c22\u6c14\u53d1\u751f\u5668\u3001\u8c01\u3001\u8d1d\u58f3\u91cc\u7684\u4e7e\u5764\u3001Freesky\u548c\u66fe\u6587\u4eae\u3002\u6b22\u8fce\u6709\u5fd7\u4e4b\u58eb\u52a0\u5165\u6211\u4eec\u56e2\u961f\u3002\u6295\u7a3f\u3001\u5408\u4f5c\u3001\u52a0\u4e13\u4e1a\u7fa4\u8bf7\u52a0\u5fae\u4fe1437180999\uff0c\u4e8c\u5343\u4ebaQQ\u7fa422711855\u3002<\/span><\/p>\n


            <\/p>\n

            \u8d23\u4efb\u7f16\u8f91\uff1a\u96f7\u8bfa\u5c9b<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

            \u672c\u6587\u6765\u6e90\uff1a\u79d1\u777f\u552f\u5b89 \/ \u4e2d\u6587\u7ffb\u8bd1\uff1a\u9a6c\u4e50\u4f1f\uff1b\u8f6c\u8f7d\u5df2\u83b7\u6388\u6743\u3002 \u9884\u8ba12019\u5e74\u8fdb\u5165\u5e02\u573a\u5e76\u5728202 […]<\/p>\n","protected":false},"author":1,"featured_media":83856,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/83855"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=83855"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/83855\/revisions"}],"predecessor-version":[{"id":83865,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/83855\/revisions\/83865"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/83856"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=83855"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=83855"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=83855"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}