{"id":83917,"date":"2019-04-14T00:00:50","date_gmt":"2019-04-17T03:08:21","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/83917\/"},"modified":"2019-04-17T11:08:23","modified_gmt":"2019-04-17T03:08:23","slug":"4bac6986ff","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/83917\/","title":{"rendered":"\u660e\u80f6\u80f6\u56ca\u4ea4\u8054\u95ee\u9898\u7684\u7814\u7a76\u601d\u8def"},"content":{"rendered":"
\n

\u80f6\u56ca\u5242\u662f\u6307\u836f\u7269\u6216\u52a0\u6709\u8f85\u6599\u5145\u586b\u4e8e\u7a7a\u5fc3\u80f6\u56ca\u6216\u5bc6\u5c01\u4e8e\u8f6f\u8d28\u56ca\u6750\u4e2d\u7684\u56fa\u4f53\u5236\u5242\u3002\u6839\u636e\u80f6\u56ca\u7684\u6eb6\u89e3\u4e0e\u91ca\u653e\u7279\u6027\u53ef\u5206\u4e3a\u786c\u80f6\u56ca\u3001\u8f6f\u80f6\u56ca\u3001\u8c03\u91ca\u80f6\u56ca\u7b49\u3002\u6839\u636e\u56ca\u6750\u7684\u4e0d\u540c\uff0c\u53c8\u53ef\u5206\u4e3a\u660e\u80f6\u80f6\u56ca\u548c\u975e\u660e\u80f6\u80f6\u56ca\uff08\u5982HPMC\u80f6\u56ca\uff09\u3002\u5176\u5185\u5bb9\u7269\u5305\u62ec\u975e\u6c34\u6eb6\u6db2\u3001\u6df7\u60ac\u6db2\u3001\u534a\u56fa\u4f53\u3001\u56fa\u4f53\u7c89\u672b\u3001\u5fae\u4e38\u3001\u9897\u7c92\u7b49\u3002\u660e\u80f6\u7a7a\u5fc3\u80f6\u56ca\u662f\u7531\u80f6\u56ca\u7528\u660e\u80f6\u52a0\u8f85\u6599\u5236\u6210\u7684\u7a7a\u5fc3\u786c\u80f6\u56ca\uff0c\u5728\u80f6\u56ca\u5242\u4e2d\u5e94\u7528\u6700\u591a\u3002<\/p>\n

\"\u660e\u80f6\u80f6\u56ca\u4ea4\u8054\u95ee\u9898\u7684\u7814\u7a76\u601d\u8def\"<\/p>\n

\u660e\u80f6\u80f6\u56ca\u4ea4\u8054\u73b0\u8c61\u6307\u660e\u80f6\u56ca\u58f3\u5728\u8d2e\u5b58\u8fc7\u7a0b\u4e2d\u53d1\u751f\u4ea4\u8054\u53cd\u5e94\uff0c\u4f7f\u5236\u5242\u5728\u4e0d\u52a0\u9176\u7684\u6eb6\u51fa\u4ecb\u8d28\u4e2d\u7684\u5d29\u89e3\u3001\u6eb6\u51fa\u3001\u91ca\u653e\u6548\u7387\u964d\u4f4e\u7684\u73b0\u8c61\u3002\u5728\u836f\u7269\u7684\u7a33\u5b9a\u6027\u8003\u5bdf\u8bd5\u9a8c\u4e2d\uff0c\u80f6\u56ca\u4ea4\u8054\u73b0\u8c61\u7ecf\u5e38\u51fa\u73b0\uff0c\u8868\u73b0\u4e3a\u5728\u8fdb\u884c\u6eb6\u51fa\u8bd5\u9a8c\u65f6\u80f6\u56ca\u53d8\u6210\u4e86\u4e00\u4e2a\u7c7b\u4f3c\u6a61\u80f6\u8d28\u6837\u7684\u80c0\u5927\u7684\u6c34\u4e0d\u6eb6\u819c\uff0c\u6b64\u6c34\u4e0d\u6eb6\u819c\u5728\u6eb6\u51fa\u8bd5\u9a8c\u4e2d\u80fd\u591f\u4f7f\u80f6\u56ca\u7684\u5d29\u89e3\u65f6\u95f4\u5ef6\u957f\u3001\u836f\u7269\u6eb6\u51fa\u901f\u7387\u4e0b\u964d\u3001\u751a\u81f3\u9020\u6210\u836f\u7269\u5b8c\u5168\u4e0d\u80fd\u6eb6\u51fa\u3002<\/p>\n

\"\u660e\u80f6\u80f6\u56ca\u4ea4\u8054\u95ee\u9898\u7684\u7814\u7a76\u601d\u8def\"<\/p>\n

\u7bee\u6cd5\u4e2d\u7684\u80f6\u56ca\u4ea4\u8054\u73b0\u8c61<\/p>\n

\"\u660e\u80f6\u80f6\u56ca\u4ea4\u8054\u95ee\u9898\u7684\u7814\u7a76\u601d\u8def\"<\/p>\n

\u6868\u6cd5\u4e2d\u7684\u80f6\u56ca\u4ea4\u8054\u73b0\u8c61<\/p>\n

\u9047\u5230\u660e\u80f6\u80f6\u56ca\u4ea4\u8054\u95ee\u9898\u5982\u4f55\u601d\u8003\u4e0e\u5e94\u5bf9\uff1f\u672c\u6587\u6d45\u8c08\u4e00\u4e0b\u7814\u7a76\u601d\u8def\uff0c\u4ec5\u4f9b\u836f\u7269\u7814\u53d1\u540c\u4ec1\u53c2\u8003\u3002 <\/p>\n

\u4e00\u3001\u4ea4\u8054\u53cd\u5e94\u7684\u673a\u7406\u53ca\u9632\u6b62\u63aa\u65bd <\/strong><\/span><\/h1>\n

\u660e\u80f6\u662f\u4e00\u7cfb\u5217\u6c34\u6eb6\u6027\u80f6\u539f\u86cb\u767d\u884d\u751f\u7269\u7684\u6df7\u5408\u7269\uff0c\u5b83\u662f\u4e00\u79cd\u7ebf\u6027\u9ad8\u5206\u5b50\u805a\u5408\u7269\uff0c\u5206\u5b50\u91cf15000\u81f325000\uff0c\u7531\u9170\u80fa\u952e\u8fde\u63a5\u5404\u79cd\u6c28\u57fa\u9178\u6784\u6210\uff0c\u7ec4\u6210\u7684\u6c28\u57fa\u9178\u5305\u62ec:\u7518\u6c28\u917825.5%\uff1b\u812f\u6c28\u917818.0%\uff1b\u7f9f\u812f\u6c28\u917814.1%\uff1b\u8c37\u6c28\u917811.4%\uff1b\u4e19\u6c28\u91788.5%\uff1b\u7cbe\u6c28\u91788.5%\uff1b\u5929\u95e8\u51ac\u6c28\u91786.6%\uff1b\u8d56\u6c28\u91784.1%\uff1b\u4eae\u6c28\u91783.2%\uff1b\u7f2c\u6c28\u91782.5%\uff1b\u82ef\u4e19\u6c28\u91782.2%\uff1b\u82cf\u6c28\u91781.9%\uff1b\u5f02\u4eae\u6c28\u91781.4%\uff1b\u86cb\u6c28\u91781.0%\uff1b\u7ec4\u6c28\u91780.8%\uff1b\u916a\u6c28\u91780.5%\uff1b\u4e1d\u6c28\u91780.4%\uff1b\u80f1\u6c28\u91780.1%\uff1b\u534a\u80f1\u6c28\u91780.1%\u3002 <\/p>\n

\u4ea4\u8054\u53cd\u5e94\u7684\u5f62\u6210\u4e3b\u8981\u5f52\u56e0\u4e8e\u6709\u4e09\u4e2a\u5b98\u80fd\u56e2\u7684\u6c28\u57fa\u9178\uff0c\u5c24\u5176\u662f\u8d56\u6c28\u9178\u3002\u4e00\u4e9b\u62a5\u9053\u63d0\u51fa\u7ec4\u6c28\u9178\u548c\u7cbe\u6c28\u9178\u4e5f\u53c2\u4e0e\u4ea4\u8054\u53cd\u5e94\u7684\u5f62\u6210\u3002 <\/span><\/p>\n

1\u3001\u4ea4\u8054\u53cd\u5e94\u7684\u4e3b\u8981\u673a\u7406 <\/strong><\/span><\/h2>\n
    \n
  • \n

    \u660e\u80f6\u4e2d\u8d56\u6c28\u9178\u6e38\u79bb\u6c28\u57fa\u9178\u6b8b\u57fa\u95f4\u53d1\u751f\u4ea4\u8054\u53cd\u5e94\u3002<\/strong><\/p>\n<\/li>\n<\/ul>\n

    \u8d56\u6c28\u9178\u6b8b\u57fa\u7684\u6c27\u5316\u53bb\u6c28\u57fa\u5316\uff0c\u5f97\u5230\u4e00\u4e2a\u672b\u7aef\u7684\u919b\u5b98\u80fd\u56e2\uff0c\u8fd9\u4e2a\u919b\u4e0e\u76f8\u90bb\u8d56\u6c28\u9178\u7684<\/span>\u03b5-\u6c28\u57fa\u7ed3\u5408\u5f97\u5230\u4e00\u4e2a\u4e9a\u80fa\uff0c\u7136\u540e\u7ecf\u8fc7\u4e00\u7cfb\u5217aldol\uff08\u7f9f\u919b\u53cd\u5e94\uff09\u7c7b\u7f29\u5408\u53cd\u5e94\u5f97\u5230\u542b\u6709\u5421\u5576\u73af\u7684\u4ea4\u8054\u4ea7\u7269\u3002<\/p>\n

      \n
    • \n

      \u8d56\u6c28\u9178\u4e0e\u5916\u6e90\u7684\u919b\u53d1\u751f\u4ea4\u8054\u53cd\u5e94\u3002<\/strong><\/p>\n<\/li>\n<\/ul>\n

      \u8d56\u6c28\u9178\u03b5-\u6c28\u57fa\u4e0e\u5916\u6e90\u7684\u919b\uff0c\u6bd4\u5982\u5904\u65b9\u4e2d\u7684\u6742\u8d28\u6216\u5904\u65b9\u4e0e\u5916\u754c\u73af\u5883\u63a5\u89e6\u540e\u751f\u6210\u7684\u919b\u53d1\u751f\u53cd\u5e94\u3002\u8fd9\u4e2a\u53cd\u5e94\u751f\u6210\u4e00\u4e2a\u7f9f\u7532\u57fa\u6c28\u57fa\u884d\u751f\u7269\uff0c\u8131\u6c34\u540e\u751f\u6210\u542b\u6709\u4e00\u4e2a\u9633\u79bb\u5b50\u7684\u4e9a\u80fa\uff0c\u540e\u8005\u4e0e\u53e6\u4e00\u5206\u5b50\u7684\u7f9f\u7532\u57fa\u6c28\u57fa\u8d56\u6c28\u9178\u6b8b\u57fa\u751f\u6210\u4e8c\u4e9a\u7532\u57fa\u919a\uff0c\u6700\u540e\u91cd\u6392\u751f\u6210\u4e00\u4e2a\u8fde\u63a5\u4e24\u4e2a\u8d56<\/span>\u6c28\u9178\u03b5-\u6c28\u57fa\u7684\u4e9a\u7532\u57fa\uff0c\u4ece\u800c\u5f62\u6210\u4ea4\u8054\u3002<\/p>\n

        \n
      • \n

        \u5f62\u6210\u80fa\u7f29\u919b\u540e\u53d1\u751f\u4ea4\u8054\u53cd\u5e94\u3002<\/strong><\/p>\n<\/li>\n<\/ul>\n

        \u80fa\u7f29\u919b\uff0c\u5373\u4e59\u7f29\u919b\u7684\u6c28\u57fa\u5f62\u5f0f\u3002\u80fa\u7f29\u919b\u662f\u901a\u8fc7\u9633\u79bb\u5b50\u4e9a\u80fa\u4e2d\u95f4\u4f53\uff08\u540c\u4e0a\u8ff0\u9633\u79bb\u5b50\u4e9a<\/span>\u80fa\u7684\u5f62\u6210\u8fc7\u7a0b\uff09\u4e0e\u4e00\u4e2a\u6e38\u79bb\u6c28\u57fa\u53cd\u5e94\u751f\u6210\u3002\u8fd9\u4e00\u53cd\u5e94\u5bf9\u5468\u56f4\u7684pH\u5f88\u654f\u611f\u3002 \u4eba\u4f53\u80c3\u6db2\u7684\u73af\u5883\u4e0e\u4f53\u5916\u6eb6\u51fa\u73af\u5883\u4e0d\u540c\uff0c\u80c3\u6db2\u4e2d\u542b\u6709\u9176\uff0c\u80f6\u56ca\u4ea4\u8054\u5f15\u8d77\u7684\u6eb6\u51fa\u5ef6\u8fdf\u6216\u4e0d\u6eb6\u51fa\u5bf9\u4e8e\u4f53\u5185\u6eb6\u51fa\u7a76\u7adf\u6709\u6ca1\u6709\u610f\u4e49\u76ee\u524d\u8fd8\u5f88\u96be\u4e0b\u7ed3\u8bba\u3002\u5728\u80f6\u56ca\u5242\u4ea7\u54c1\u7684\u5f00\u53d1\u9636\u6bb5\uff0c\u80fd\u591f\u53ef\u80fd\u5bfc\u81f4\u4ea4\u8054\u95ee\u9898\u7684\u6bcf\u4e00\u4e2a\u56e0\u7d20\u90fd\u5e94\u4ed4\u7ec6\u8003\u8651\uff0c\u4ece\u65e9\u671f\u8bbe\u8ba1\u9636\u6bb5\u5c31\u8981\u5c3d\u53ef\u80fd\u907f\u514d\uff0c\u6216\u8005\u901a\u8fc7\u9ad8\u6e29\u3001\u9ad8\u6e7f\u8bd5\u9a8c\u6765\u8fdb\u884c\u9884\u5224\uff0c\u5c3d\u65e9\u91c7\u53d6\u63aa\u65bd\u8fdb\u884c\u9632\u6b62\u6216\u5236\u5b9a\u76f8\u5e94\u7814\u7a76\u5bf9\u7b56\u3002 <\/p>\n

        2\u3001\u9632\u6b62\u4ea4\u8054\u53cd\u5e94\u7684\u65b9\u6cd5<\/span> <\/strong><\/span><\/h2>\n
          \n
        • \n

          \u9009\u62e9\u4e0d\u6613\u4ea7\u751f\u919b\u7c7b\u7269\u8d28\u6216\u4e0d\u6613\u4fc3\u8fdb\u4ea4\u8054\u53cd\u5e94\u53d1\u751f\u7684\u8f85\u6599\u3002<\/strong><\/p>\n<\/li>\n<\/ul>\n

          \u5728\u5236\u5242\u7684\u8f85\u6599\u4e2d\uff0c\u589e\u5851\u5242\u3001\u9632\u8150\u5242\u3001\u8102\u80aa\u3001\u805a\u4e59\u70ef\u5316\u5408\u7269\u6bd4\u5982\uff1aPEG\u3001\u8102\u80aa\u65cf\u9187\u7c7b\u3001\u8102\u80aa\u65cf\u915a\u7c7b\u3001\u805a\u4e59\u70ef\u7518\u6cb9\u916f\u7b49\u5747\u6613\u4ea7\u751f\u919b\u7c7b\u7269\u8d28\u3002\u975e\u79bb\u5b50\u8868\u9762\u6d3b\u6027\u5242\u5410\u6e2980\uff0c\u7531\u4e8e\u5206\u5b50\u4e2d\u542b\u6709\u805a\u6c27\u4e59\u70ef\u57fa\uff0c\u6613\u53d1\u751f\u6c27\u5316\u964d\u89e3\uff0c\u5f62\u6210\u7532\u919b\u3002<\/span><\/p>\n

            \n
          • \n

            \u5bf9\u4e8e\u6613\u4ea7\u751f\u4ea4\u8054\u53cd\u5e94\u7684\u836f\u7269\uff0c\u4e0d\u5b9c\u5f00\u53d1\u6210\u786c\u80f6\u56ca\u3001\u8f6f\u80f6\u56ca\u7b49\u5242\u578b\u3002<\/strong><\/p>\n<\/li>\n<\/ul>\n

            \u5982\u5409\u975e\u8d1d\u9f50\u3001\u4f9d\u6258\u5ea6\u9178\u3001\u6c2f\u9709\u7d20\u3001\u544b\u5583\u59a5\u56e0\u3001\u6251\u70ed\u606f\u75db\u3001\u5730\u9ad8\u8f9b\u3001\u7ef4\u751f\u7d20\u3001\u5e03\u6d1b\u82ac\u7b49\u5728\u653e\u6837\u8fc7\u7a0b\u4e2d\u5747\u51fa\u73b0\u6eb6\u51fa\u5ea6\u663e\u8457\u4e0b\u964d\u7684\u60c5\u51b5\u3002\u542b\u6709\u919b\u57fa\u7684\u836f\u7269\u4e0e\u660e\u80f6\u6b8b\u57fa\u53d1\u751f\u53cd\u5e94\uff0c\u4f7f\u660e\u80f6\u53d1\u751f\u4ea4\u8054\u3002<\/span><\/p>\n

              \n
            • \n

              \u63a7\u5236\u5916\u754c\u73af\u5883\u4e2d\u6e29\u5ea6\u3001\u6e7f\u5ea6\u3001\u5149\u7167\u7b49\u56e0\u7d20\u7684\u5f71\u54cd\u3002<\/strong><\/p>\n<\/li>\n<\/ul>\n

              \u4ea4\u8054\u53cd\u5e94\u7684\u53d1\u751f\u53d7\u5916\u754c\u73af\u5883\u4e2d\u6e29\u5ea6\u3001\u6e7f\u5ea6\u3001\u5149\u7ebf\u7684\u5f71\u54cd\u3002\u80f6\u56ca\u5e94\u8d2e\u5b58\u5728\u6e29\u5ea615~25\u2103\uff0c<\/span>\u76f8\u5bf9\u6e7f\u5ea630%~40%\uff0c\u9634\u51c9\u5e72\u71e5\u907f\u5149\u5904\u8d2e\u5b58\u3002\u5ba4\u6e29\u4e0b\u4ea4\u8054\u53cd\u5e94\u8f83\u4e0d\u6613\u53d1\u751f\uff0c\u957f\u671f\u50a8\u5b58\u4e8e\u9ad8\u6e29\u4e0b\u7684\u660e\u80f6\u5206\u5b50\u4e2d\u6c28\u57fa\u9178\u6b8b\u57fa\u6613\u53d1\u751f\u81ea\u6c27\u5316\u800c\u5f62\u6210\u919b\u57fa,\u5f62\u6210\u7684\u919b\u57fa\u53ef\u4ee5\u548c\u5468\u56f4\u660e\u80f6\u5206\u5b50\u4e0a\u7684\u6c28\u57fa\u9178\u6b8b\u57fa\u53d1\u751f\u4ea4\u8054\u53cd\u5e94,\u4f7f\u660e\u80f6\u5206\u5b50\u7ed3\u6784\u53d1\u751f\u53d8\u5316\u540e,\u6c34\u6eb6\u6027\u5927\u5e45\u4e0b\u964d\u3002\u5e76\u4e14\u968f\u7740\u6e29\u5ea6\u7684\u5347\u9ad8\uff0c\u4ea4\u8054\u53cd\u5e94\u7684\u7a0b\u5ea6\u8d8a\u5267\u70c8\u3002\u9ad8\u6e7f\u6761\u4ef6\u7684\u5f71\u54cd\u5c24\u4e3a\u91cd\u5927\uff0c\u5b83\u53ef\u4ee5\u50ac\u5316\u4e9a\u80fa\u4e2d\u95f4\u4f53\u7684\u5f62\u6210\uff0c\u50ac\u5316\u8f85\u6599\u964d\u89e3\u6210\u4fc3\u8fdb\u4ea4\u8054\u53cd\u5e94\u53d1\u751f\u7684\u964d\u89e3\u4ea7\u7269\uff0c\u540c\u65f6\u4f7f\u6c27\u6c14\u66f4\u5bb9\u6613\u7a7f\u900f\u660e\u80f6\u5206\u5b50\uff0c\u4ece\u800c\u52a0\u901f\u5bf9\u5b83\u7684\u6c27\u5316\u4f5c\u7528\u3002\u7d2b\u5916\u53ef\u89c1\u5149\u4e0e\u9ad8\u6e29\u3001\u9ad8\u6e7f\u76f8\u4e92\u4f5c\u7528\u4e5f\u4fc3\u8fdb\u4e86\u4ea4\u8054\u53cd\u5e94\u7684\u53d1\u751f\u548c\u4fc3\u8fdb\u660e\u80f6\u7684\u81ea\u6c27\u5316\u6709\u5173\u3002<\/p>\n

                \n
              • \n

                \u56ca\u58f3\u5904\u65b9\u56e0\u7d20\u7684\u5f71\u54cd<\/strong><\/p>\n<\/li>\n<\/ul>\n

                \u56ca\u58f3\u5904\u65b9\u662f\u51b3\u5b9a\u56ca\u58f3\u4ea4\u8054\u7684\u4e3b\u8981\u56e0\u7d20\uff1a(1)\u660e\u80f6\u7684\u9009\u62e9\uff1a\u660e\u80f6\u7684\u4ea4\u8054\u7a0b\u5ea6\u4e3b\u8981\u662f\u53d7\u660e\u80f6\u4e2d\u6c28\u57fa\u9178\u7684\u6b8b\u57fa\u91cf\u5f71\u54cd\uff0c\u660e\u80f6\u4e2d\u8d56\u6c28\u9178\u548c\u7cbe\u6c28\u9178\u7684\u542b\u91cf\u8d8a\u4f4e\uff0c\u5219\u4ea4\u8054\u53d1\u751f\u7a0b\u5ea6\u548c\u53ef\u80fd\u6027\u8d8a\u4f4e\u3002(2)\u56ca\u58f3\u7684\u542b\u6c34\u91cf\uff1a\u56ca\u58f3\u4e2d\u542b\u6c34\u91cf\u9ad8\u65f6\uff0c\u53ef\u4ee5\u52a0\u5feb\u660e\u80f6\u7684\u6c27\u5316\uff0c\u4f7f\u4e9a\u80fa\u4e2d\u95f4\u4f53\u7684\u4ea7\u751f<\/span>\u52a0\u5feb\u3002(3)\u589e\u5851\u5242\uff1a\u7518\u6cb9\u548c\u5c71\u68a8\u9187\u7b49\u589e\u5851\u5242\u4f1a\u4f7f\u660e\u80f6\u7684\u81ea\u6c27\u5316\u4f5c\u7528\u589e\u5f3a\u3002(4)\u906e\u5149\u5242\u548c\u7740\u8272\u5242\uff1a\u52a0\u5165\u7684\u906e\u5149\u5242\u548c\u7740\u8272\u5242\u53ef\u80fd\u8bf1\u5bfc\u919b\u7c7b\u5206\u5b50\u4ea7\u751f\uff0c\u4ece\u800c\u4e0e\u660e\u80f6\u53d1\u751f\u80fa\u7f29\u919b\u53cd\u5e94\u3002(5)\u94c1\u79bb\u5b50\uff1a\u80f6\u56ca\u4e2d\u542b\u6709\u94c1\u79bb\u5b50\uff0c\u4f7f\u6c28\u57fa\u9178\u7ecf\u82ac\u987f\u5316\u5b66\u53cd\u5e94\uff0c\u751f\u6210\u7f9f\u57fa\u81ea\u7531\u57fa(\u00b7OH)\uff0c\u7f9f\u57fa\u81ea\u7531\u57fa\u6c27\u5316\u6c28\u57fa\u9178\u7684\u6c28\u57fa\u548c\u4e2d\u5fc3\u78b3\u539f\u5b50\uff0c\u5bfc\u81f4\u660e\u80f6\u4ea4\u8054\uff0c\u4f46\u94c1\u79bb\u5b50\u542b\u91cf\u5bf9\u4ea4\u8054\u73b0\u8c61\u7684\u5f71\u54cd\u4e0d\u80fd\u786e\u5b9a\u3002(6)\u94c1\u79bb\u5b50\u548c\u94dd\u79bb\u5b50\uff1aFe3+\u9664\u50ac\u5316\u7f9f\u57fa\u81ea\u7531\u57fa\u751f\u6210\u5916\uff0cFe3+\u548cAl3+\u80fd\u4e0e\u660e\u80f6\u6e38\u79bb\u7684\u7f9f\u57fa\u5f62\u6210\u914d\u5408\u7269\u3002 <\/p>\n

                \u4e8c\u3001\u660e\u80f6\u80f6\u56ca\u4ea4\u8054\u7814\u7a76\u7684\u6307\u5bfc\u539f\u5219USP<711> <\/strong><\/span><\/h1>\n

                USP<711> Dissolution\u6eb6\u51fa\u5ea6\u9879\u4e0b\u89c4\u5b9a\uff0c\u5982\u679c\u662f\u56e0\u4e3a\u4ea4\u8054\u5f15\u8d77\u4e86\u6eb6\u51fa\u5ea6\u4e0d\u7b26\u5408\u6807\u51c6\u89c4\u5b9a\uff0c\u5e94\u8fdb\u884c\u4e8c\u7ea7\u6eb6\u51fa\u8bd5\u9a8c\uff08Tier II\uff09\uff0c\u5373\u6dfb\u52a0\u9176\u548c\u4e0d\u6dfb\u52a0\u9176\u6eb6\u51fa\u8bd5\u9a8c\u3002\u5bf9\u4e8e\u4e0d\u540cpH\u7684\u6eb6\u51fa\u4ecb\u8d28\uff0c\u9009\u7528\u7684\u9176\u7684\u79cd\u7c7b\u4e5f\u4e0d\u4e00\u6837\uff0c\u4ee5\u4e0b\u4e3a\u5404\u4e2apH\u6761\u4ef6\u4e0b\u63a8\u8350\u7684\u9176\u79cd\u7c7b\u3001\u6d53\u5ea6\u3001\u6d3b\u6027\u6d4b\u5b9a\u6807\u51c6\/\u65b9\u6cd5\uff08\u5f88\u6709\u7528\u54e6\uff01\uff09\u3002<\/span><\/p>\n

                  \n
                • \n

                  Dissolution Medium with pH 4.0<\/strong><\/p>\n<\/li>\n<\/ul>\n

                  Enzyme: Pepsin\uff08\u80c3\u86cb\u767d\u9176\uff09, activity determined by the procedure in purified pepsin, in the Reagent Specifications section<\/span><\/p>\n

                  Amount: A quantity of pepsin that results in an activity of NMT 750,000 Units\/L of dissolution medium<\/span><\/p>\n

                    \n
                  • \n

                    Dissolution Medium with pH >4.0 and <6.8<\/strong><\/p>\n<\/li>\n<\/ul>\n

                    Enzyme: Papain\uff08\u6728\u74dc\u86cb\u767d\u9176\uff09, activity determined by the Assay test in the monograph for Papain; or bromelain\uff08\u83e0\u841d\u86cb\u767d\u9176\uff09, activity determined by the procedure in bromelain, in the Reagent Specifications section<\/span><\/p>\n

                    Amount: A quantity of papain that results in an activity of NMT 550,000 Units\/L of dissolution medium, or a quantity of bromelain that results in an activity of NMT 30 gelatin-digesting units (GDU)\/L of dissolution medium<\/span><\/p>\n

                      \n
                    • \n

                      Dissolution Medium with pH 6.8<\/strong><\/p>\n<\/li>\n<\/ul>\n

                      Enzyme: Pancreatin\uff08\u80f0\u9176\uff09, protease activity determined by the procedure in Assay for protease activity (Casein digestive power) in the monograph for Pancreatin<\/span><\/p>\n

                      Amount: A quantity of pancreatin that results in a protease activity of NMT 2000 Units\/L of dissolution medium<\/span><\/p>\n

                      \u6eb6\u51fa\u4ecb\u8d28\u4e2d\u542b\u6709\u8868\u9762\u6d3b\u6027\u5242\u6216\u5176\u4ed6\u80fd\u5f71\u54cd\u9176\u6d3b\u6027\u7684\u5176\u4ed6\u6210\u5206\u65f6\uff0cUSP\u4e5f\u6709\u91cd\u8981\u8bf4\u660e\uff0c\u4f5c\u8005\u5c06\u539f\u6587\u53ca\u4e3b\u8981\u7ffb\u8bd1\u5217\u4e3e\u5982\u4e0b\uff1a<\/span><\/p>\n

                      If the dissolution medium contains surfactant or other ingredients that are known to denature the enzyme used, a pretreatment step in the dissolution testing of the dosage form may be applied\uff08\u52a0\u5165\u9884\u5904\u7406\u6b65\u9aa4\uff09.This pretreatment step is done using the specified dissolution medium without the surfactant or the ingredient and with the addition of the appropriate amount of enzyme according to the medium pH\uff08\u9884\u5904\u7406\u6b65\u9aa4\u4e2d\u4e0d\u542b\u7834\u574f\u6210\u5206\u53ea\u542b\u6709\u9002\u5f53\u7684\u9176\uff09. The amount of enzyme added is appropriate to the volume of dissolution medium used in the pretreatment\uff08\u9176\u7684\u91cf\u5e94\u8be5\u9002\u5f53\uff09.To achieve the specified medium volume for the final dissolution testing, the pretreatment step may be conducted with a smaller volume of medium without the ingredient such that the final volume is obtained when the ingredient is added at the end of the pretreatment step\uff08\u9884\u5904\u7406\u6b65\u9aa4\u4e2d\u5e94\u91c7\u7528\u4e00\u4e2a\u5c0f\u7684\u4ecb\u8d28\u4f53\u79ef\uff0c\u9884\u5904\u7406\u6b65\u9aa4\u7ed3\u675f\u540e\u52a0\u81f3\u6700\u7ec8\u4f53\u79ef\uff09. All of the other conditions of the test (apparatus, rotation, orflow rate) should remain as described in the method or monograph\uff08\u6eb6\u51fa\u6761\u4ef6\u4e0e\u6807\u51c6\u65b9\u6cd5\u76f8\u540c\uff09. Typically, the duration of the pretreatment step is NMT 15 min\uff08\u901a\u5e38\uff0c\u9884\u5904\u7406\u6b65\u9aa4\u4e0d\u8d85\u8fc715min\uff09. The required pretreatment time should be evaluated on a case-by-case basis and should be scientifically justified\uff08\u6240\u9700\u7684\u9884\u5904\u7406\u65f6\u95f4\u5177\u4f53\u95ee\u9898\u5177\u4f53\u5206\u6790\uff0c\u5e94\u8fdb\u884c\u79d1\u5b66\u8bf4\u660e\uff09. This time should be included in the total time of the test\uff08\u9884\u5904\u7406\u65f6\u95f4\u5305\u62ec\u5728\u603b\u6d4b\u5b9a\u65f6\u95f4\u4e2d\uff09. As an example, if the total time of the test is 45 min and 15 minare used in the pretreatment step, the test will continue for 30 min after the addition of the ingredient\uff08\u4f8b\u5982\uff0c\u603b\u6eb6\u51fa\u65f6\u95f4\u4e3a45min\uff0c\u9884\u5904\u7406\u4e3a15min\uff0c\u52a0\u5165\u5176\u5b83\u6210\u5206\u540e\u7ee7\u7eed\u8fdb\u884c30min\uff09\u3002<\/span><\/p>\n

                      \u4e86\u89e3\u5f71\u54cd\u9176\u6d3b\u6027\u7684\u8868\u9762\u6d3b\u6027\u5242\u79cd\u7c7b\u5f88\u91cd\u8981\u3002Guzman\u7b49\u5c31\u80c3\u86cb\u767d\u9176\u5206\u522b\u5728\u542b\u5341\u4e8c\u70f7\u57fa\u786b\u9178\u94a0(SDS)\u3001\u5341\u516d\u70f7\u57fa\u4e09\u7532\u57fa\u6eb4\u5316\u94f5(CTAB)\u3001\u805a\u4e59\u4e8c\u9187\u8f9b\u57fa\u82ef\u57fa\u919a(Triton X-100)\u548c\u5410\u6e29-80\u56db\u79cd\u8868\u9762\u6d3b\u6027\u5242\u7684\u6eb6\u51fa\u4ecb\u8d28\u4e2d\u7684\u6d3b\u6027\u8fdb\u884c\u4e86\u5b9e\u9a8c\u3002\u7ed3\u679c\u8868\u660e\uff0c\u6dfb\u52a0SDS\u4f1a\u964d\u4f4e\u80c3\u86cb\u767d\u9176\u7684\u6d3b\u6027\uff0c\u5373\u4f7f\u4f4e\u6d53\u5ea6SDS\u4ecd\u4f1a\u660e\u663e\u964d\u4f4e\u5176\u6d3b\u6027\u3002\u800c\u6dfb\u52a0\u4efb\u610f\u6d53\u5ea6\u7684CTAB\u3001Triton X-100 \u548c\u5410\u6e29-80\u5747\u4e0d\u4f1a\u5f71\u54cd\u80c3\u86cb\u767d\u9176\u7684\u6d3b\u6027\u3002Guncheva\u7b49\u5bf9\u80f0\u86cb\u767d\u9176\u8fdb\u884c\u76f8\u4f3c\u7814\u7a76\uff0c\u7ed3\u679c\u4e3a\u975e\u79bb\u5b50\u578b\u8868\u9762\u6d3b\u6027\u5242(\u5410\u6e29-80\u548cTriton X-100)\u80fd\u591f\u589e\u5f3a\u80f0\u86cb\u767d\u9176\u7684\u6d3b\u6027\uff0c\u800c\u79bb\u5b50\u578b\u8868\u9762\u6d3b\u6027\u5242(SDS\u548cCTAB)\u4f1a\u6291\u5236\u5176\u6d3b\u6027\uff0c\u56e0\u6b64\u5728\u6dfb\u52a0\u80f0\u86cb\u767d\u9176\u7684\u4f53\u5916\u6eb6\u51fa\u8bd5\u9a8c\u4e2d\u5efa\u8bae\u4f7f\u7528\u975e\u79bb\u5b50\u578b\u8868\u9762\u6d3b\u6027\u5242\u3002\u5173\u4e8e\u8868\u9762\u6d3b\u6027\u5242\u5bf9\u6eb6\u51fa\u4ecb\u8d28\u4e2d\u6728\u74dc\u86cb\u767d\u9176\u548c\u83e0\u841d\u86cb\u767d\u9176\u6d3b\u6027\u7684\u5f71\u54cd\u7814\u7a76\u5c1a\u672a\u89c1\u62a5\u9053\u3002<\/span><\/p>\n

                      \u4e09\u3001\u95ee\u9898\u5206\u6790\u4e0e\u8ba8\u8bba<\/strong><\/span><\/h1>\n

                      1\u3001\u5982\u4f55\u7406\u89e3FDA\u6eb6\u51fa\u6570\u636e\u5e93\u4e2d\u7684Tier I\u548cTier II\uff1f<\/span><\/strong><\/span><\/h2>\n

                      \u4ee5Ziprasidone HCl\u80f6\u56ca\u4e3a\u4f8b\uff0cFDA\u6eb6\u51fa\u6570\u636e\u5e93\u4e2d\u89c4\u5b9a\u4e86Tier I\u548cTier II\u65b9\u6cd5\uff0c\u89c1\u4e0b\u8868\u3002\u6839\u636eUSP711\uff0c\u5982\u679c\u80f6\u56ca\u6709\u4ea4\u8054\u73b0\u8c61\uff0c\u53ef\u4ee5\u5728\u4ecb\u8d28\u4e2d\u52a0\u5165\u9176\u3002\u5982\u679c\u6eb6\u51fa\u4ecb\u8d28\u4e2d\u542b\u6709\u8868\u9762\u6d3b\u6027\u5242\uff0c\u9176\u6d3b\u6027\u4f1a\u53d7\u5230\u7834\u574f\uff0c\u56e0\u6b64\u9700\u8981\u91c7\u7528\u65e0\u9176\u4ecb\u8d28\u8fdb\u884c\u9884\u5904\u7406\uff0c\u6700\u957f\u65f6\u95f4\u4e0d\u5f97\u8d85\u8fc715min\uff0c\u7136\u540e\u518d\u52a0\u5165\u542b\u9176\u4ecb\u8d28\u3002\u672c\u4f8b\u4e2d\u7684\u610f\u601d\u662f\uff0c\u8be5\u80f6\u56ca\u91c7\u7528Tier I\u8fdb\u884c\u6eb6\u51fa\u6d4b\u8bd5\uff0c\u5f53\u53d1\u751f\u4ea4\u8054\u7684\u65f6\u5019\u53ef\u91c7\u7528Tier II\u3002\u5982\u679c\u91c7\u7528Tier I\u65b9\u6cd5\u65f6\u53d1\u73b0S1\u9636\u6bb5\u4e0d\u5408\u683c\uff0c\u91c7\u7528Tier II\u5e76\u5e94\u7b26\u5408S1\u9636\u6bb5\u8981\u6c42\uff0c\u4e0d\u5fc5\u518d\u7ee7\u7eed\u91c7\u7528Tier I\u65b9\u6cd5\u7ee7\u7eed\u8003\u5bdfS2\u3001S3\u3002<\/span><\/p>\n

                      \"\u660e\u80f6\u80f6\u56ca\u4ea4\u8054\u95ee\u9898\u7684\u7814\u7a76\u601d\u8def\"<\/p>\n

                      2\u3001\u9009\u62e9\u52a0\u5165\u9176\u4e4b\u524d\u9700\u8981\u8003\u8651\u54ea\u4e9b\u95ee\u9898\uff1f<\/span><\/strong><\/span><\/h2>\n

                      \u9996\u5148\uff0c\u5e94\u786e\u5b9a\u6eb6\u51fa\u53d8\u6162\u786e\u5b9e\u662f\u7531\u80f6\u56ca\u4ea4\u8054\u5f15\u8d77\u7684\uff0c\u8fd9\u4e00\u70b9\u5f88\u91cd\u8981\u3002\u65b9\u6cd5\u6709\u76ee\u6d4b\u6cd5\uff08\u89c2\u5bdf\u5230\u80f6\u56ca\u5438\u6c34\u81a8\u80c0\uff0c\u6ca1\u6709\u7834\u88c2\u6216\u8005\u90e8\u5206\u7834\u88c2\uff09\u3001\u8f6c\u6362\u6cd5\uff08\u628a\u80f6\u56ca\u7684\u5185\u5bb9\u7269\u649e\u5230\u65b0\u7684\u6ca1\u6709\u53d1\u751f\u4ea4\u8054\u7684\u56ca\u58f3\u91cc\uff09\u3002\u5176\u6b21\uff0c\u9700\u8981\u6839\u636e\u4ecb\u8d28\u7684pH\uff0c\u53c2\u8003USP711\u9009\u62e9\u52a0\u5165\u9176\u7684\u79cd\u7c7b\u4e0e\u6765\u6e90\uff08\u5fc5\u8981\u65f6\u6839\u636e\u7814\u7a76\u60c5\u51b5\u56fa\u5b9a\u5382\u5bb6\uff09\u3002\u7b2c\u4e09\uff0c\u9700\u8981\u9176\u79cd\u7c7b\u89c4\u5b9a\u6d4b\u5b9a\u9176\u6d3b\u6027\uff0c\u5e76\u786e\u5b9a\u4e0b\u6765\u9176\u7684\u6d4b\u5b9a\u65b9\u6cd5\uff0c\u56e0\u4e3a\u9176\u7684\u6d4b\u5b9a\u65b9\u6cd5\u5f88\u5173\u952e\u3002<\/span><\/p>\n

                      3\u3001\u5728\u7a33\u5b9a\u6027\u8003\u5bdf\u8fc7\u7a0b\u4e2d\u53d1\u73b0\u4ea4\u8054\u600e\u4e48\u529e\uff1f<\/span><\/strong><\/span><\/h2>\n

                      \u9996\u5148\uff0c\u8fd8\u662f\u5fc5\u987b\u5148\u8bc4\u4f30\u5e76\u786e\u5b9a\u6eb6\u51fa\u53d8\u6162\u6216\u4e0d\u6eb6\u51fa\u662f\u7531\u4ea4\u8054\u5f15\u8d77\u7684\uff0c\u800c\u4e0d\u662f\u7531\u5236\u5242\u672c\u8eab\u6027\u80fd\u53d8\u5316\u5f15\u8d77\u7684\u3002\u5176\u6b21\uff0c\u6839\u636eUSP711\u91c7\u7528\u52a0\u9176\u7684\u65b9\u6cd5\u8fdb\u884c\u6eb6\u51fa\u5ea6\u6d4b\u8bd5\u3002\u7b2c\u4e09\uff0c\u540e\u7eed\u65f6\u95f4\u70b9\u5747\u9700\u91c7\u7528\u52a0\u9176\u7684\u65b9\u6cd5\u8fdb\u884c\u6d4b\u8bd5\uff0c\u5b8c\u6210\u6570\u636e\u5bf9\u6bd4\u3002<\/span><\/p>\n

                      4\u3001\u5728\u6bcf\u4e00\u4e2a\u6eb6\u51fa\u676f\u4e2d\u52a0\u9176\u8fd8\u662f\u914d\u5236\u542b\u9176\u7684\u4ecb\u8d28\uff1f<\/span><\/strong><\/span><\/h2>\n

                      \u6839\u636eUSP711\uff0c\u5982\u679c\u56e0\u4e3a\u4ea4\u8054\u5f15\u8d77\u6eb6\u51fa\u5ea6\u8bd5\u9a8c\u5931\u8d25\uff0c\u9996\u5148\u5e94\u8003\u8651\u590d\u6d4b\uff0c\u800c\u4e0d\u662f\u5728\u5df2\u53d1\u751f\u4ea4\u8054\u7684\u6eb6\u51fa\u676f\u4e2d\u52a0\u5165\u9176\u3002\u5982\u679c\u5728\u6bcf\u4e00\u4e2a\u6eb6\u51fa\u676f\u4e2d\u52a0\u5165\u9176\u9700\u8981\u591a\u6b21\u79f0\u91cf\uff0c\u52a0\u5165\uff0c\u6eb6\u89e3\u975e\u5e38\u9ebb\u70e6\uff0c\u56e0\u6b64\uff0c\u5efa\u8bae\u4e00\u6b21\u914d\u5236\u542b\u9176\u4ecb\u8d28\uff0c\u59826L\u30018L\u300110L\u7b49\u3002<\/span><\/p>\n

                      5\u3001\u5982\u679c\u5728\u5236\u5242\u5f00\u53d1\u9636\u6bb5\u5c31\u53d1\u73b0\u4e86\u4ea4\u8054\u73b0\u8c61\u600e\u4e48\u8003\u8651\uff1f<\/span><\/strong><\/span><\/h2>\n

                      \u9996\u5148\uff0c\u5e94\u5206\u6790\u53ef\u80fd\u7684\u539f\u56e0\uff0c\u5982\u919b\u3001\u9ad8\u6e29\u3001\u9ad8\u6e7f\u7684\u5f71\u54cd\u3002\u5904\u65b9\u4e2d\u6210\u5206\u662f\u5426\u542b\u6709\u5c11\u91cf\u7684\u919b\u7c7b\u6216\u53ef\u80fd\u4ea7\u751f\u919b\u7c7b\u7684\u7269\u8d28\uff0c\u5982\u662f\uff0c\u5e94\u8fdb\u884c\u8f85\u6599\u7684\u5185\u63a7\u6216\u8005\u66ff\u4ee3\u7814\u7a76\uff1b\u80f6\u56ca\u8d2e\u85cf\u6761\u4ef6\u662f\u5426\u6b63\u786e\uff0c\u5982\u662f\uff0c\u5e94\u9009\u62e9\u6070\u5f53\u7684\u5305\u6750\u53ca\u8d2e\u85cf\u6761\u4ef6\u3002<\/span><\/p>\n

                      6\u3001\u52a0\u9176\u7684\u6eb6\u51fa\u65b9\u6cd5\u662f\u5426\u9700\u8981\u8fdb\u884c\u65b9\u6cd5\u5b66\u9a8c\u8bc1\uff1f<\/span><\/strong><\/h2>\n

                      \u9700\u8981\u7684\u3002\u4f8b\u5982\uff0c\uff081\uff09\u5e94\u68c0\u67e5\u5e76\u786e\u5b9a\u4ecb\u8d28\u7684pH\uff1b\uff082\uff09\u6839\u636epH\u9009\u62e9\u9176\u7684\u79cd\u7c7b\uff1b\uff083\uff09\u786e\u5b9a\u9176\u6d3b\u6027\u6d4b\u5b9a\u65b9\u6cd5\uff1b\uff084\uff09\u4ecb\u8d28\u4e2d\u9176\u7684\u91cf\u5982\u4f55\u8ba1\u7b97\uff1b\uff085\uff09\u7814\u7a76\u5e76\u786e\u5b9a\u6eb6\u51fa\u5ea6\u4e0d\u7b26\u5408\u89c4\u5b9a\u662f\u7531\u80f6\u56ca\u4ea4\u8054\u5f15\u8d77\u7684\uff1b\uff086\uff09\u52a0\u5165\u9176\u540e\u7684\u6ee4\u819c\u9a8c\u8bc1\u8bd5\u9a8c\uff1b\uff087\uff09\u52a0\u5165\u9176\u540e\u5bf9\u68c0\u6d4b\u65b9\u6cd5\u662f\u5426\u4ea7\u751f\u5e72\u6270\uff08\u4e13\u5c5e\u6027\uff09\uff1b\uff088\uff09\u5982\u679c\u4ecb\u8d28\u4e2d\u542b\u6709SDS\u7b49\u8868\u9762\u6d3b\u6027\u5242\u5e94\u7814\u7a76\u9884\u5904\u7406\u6b65\u9aa4\u4e2d\u7684\u65f6\u95f4\u3001\u4f53\u79ef\uff1b\uff089\uff09\u6700\u7ec8\u5236\u5b9a\u7684\u52a0\u9176\u4e0d\u52a0\u9176\u6eb6\u51fa\u65b9\u6cd5\u3002<\/span><\/p>\n

                      \u56db\u3001\u6848\u4f8b\u5206\u4eab\uff1a\u5f00\u53d1Tier II\u65b9\u6cd5\u7684\u601d\u8def<\/span><\/strong><\/h1>\n

                      \u95ee\u9898\u63cf\u8ff0\uff1a\u67d0\u4ea7\u54c1\uff0c\u7ecf\u52a0\u901f3\u4e2a\u6708\u540e\uff0c\u91c7\u7528Tier I \u65b9\u6cd5\u6d4b\u5b9a\uff0c\u5373900 mL\u76840.01 N HCl+1.0% SDS\u6eb6\u6db2\u3002\u53d1\u73b0\u6eb6\u51fa\u66f2\u7ebf\u4e2d\u6eb6\u51fa\u91cf\u572810~60min\u660e\u663e\u4e0b\u964d\uff0c\u6279\u5185RSD\u660e\u663e\u53d8\u5927\uff0c\u6570\u636e\u5982\u4e0b\u3002\u7531\u4e8e\u9650\u5ea6\u4e3a75%@45min\uff0c\u56e0\u6b64\uff0c\u6eb6\u51fa\u5ea6\u5df2\u7ecf\u4e0d\u5408\u683c\u4e86\u3002\u5982\u4f55\u89e3\u51b3\u6b64\u7c7b\u95ee\u9898\uff1f<\/span><\/p>\n

                      \"\u660e\u80f6\u80f6\u56ca\u4ea4\u8054\u95ee\u9898\u7684\u7814\u7a76\u601d\u8def\"<\/p>\n

                      \"\u660e\u80f6\u80f6\u56ca\u4ea4\u8054\u95ee\u9898\u7684\u7814\u7a76\u601d\u8def\"<\/p>\n

                      \u901a\u8fc7\u73b0\u8c61\u89c2\u5bdf\u53d1\u73b0\uff0c\u53ef\u80fd\u662f\u7531\u4e8e\u4ea4\u8054\u5f15\u8d77\u7684\uff0c\u56e0\u6b64\u8bbe\u8ba1\u4e86\u4e09\u79cd\u5b9e\u9a8c\uff0c\u91c7\u7528\u65e7\u5185\u5bb9\u7269+\u65b0\u80f6\u56ca\u58f3\u3001\u65b0\u5185\u5bb9\u7269+\u65e7\u80f6\u56ca\u58f3\u3001\u65b0\u5185\u5bb9\u7269+\u65b0\u80f6\u56ca\u58f3\u8fdb\u884c\u6eb6\u51fa\u66f2\u7ebf\u5bf9\u6bd4\u3002\u6839\u636e\u5bf9\u6bd4\u53ef\u89c1\uff0c\u65b0\u5185\u5bb9\u7269+\u65e7\u80f6\u56ca\u58f3\u7684\u6eb6\u51fa\u91cf\u5f88\u4f4e\uff0c\u53d8\u5f02\u5927\uff0c\u56e0\u6b64\u4e0e\u5176\u4ed6\u4e24\u7ec4\u76f8\u6bd4\u8f83\u53ef\u4ee5\u5224\u65ad\u662f\u7531\u80f6\u56ca\u58f3\u4ea7\u751f\u4ea4\u8054\u5f15\u8d77\u7684\u3002<\/p>\n

                      \"\u660e\u80f6\u80f6\u56ca\u4ea4\u8054\u95ee\u9898\u7684\u7814\u7a76\u601d\u8def\"<\/p>\n

                      \u6839\u636e\u672c\u54c1\u7684\u4ecb\u8d28pH\uff0c\u9009\u62e9\u80c3\u86cb\u767d\u9176\u76f4\u63a5\u52a0\u5165\u5230900ml\u4ecb\u8d28\u4e2d\uff0c\u6d4b\u5b9a6\u7c92\u80f6\u56ca\u7684\u7ed3\u679c\u5982\u4e0b\u6240\u793a\u3002\u7ed3\u679c\u8868\u660e\uff0cSDS\u5f15\u8d77\u4e86\u9176\u7684\u964d\u89e3\uff0c\u8fd9\u79cd\u65b9\u6cd5\u4e0d\u53ef\u884c\uff0c\u5fc5\u987b\u5206\u6b65\u9aa4\u52a0\u5165\u3002<\/p>\n

                      \"\u660e\u80f6\u80f6\u56ca\u4ea4\u8054\u95ee\u9898\u7684\u7814\u7a76\u601d\u8def\"<\/p>\n

                      \u4e3a\u4e86\u53bb\u9664SDS\u5bf9\u7834\u56ca\u8bd5\u9a8c\u7684\u5f71\u54cd\uff0c\u4ecb\u8d281\u914d\u5236\u4e3a\u4e0d\u542bSDS\u76840.01 N HCL + 750,000 units\/L \u80c3\u86cb\u767d\u9176\u6eb6\u6db2\uff1b\u5148\u52a0\u5165600 mL\u4ecb\u8d281\uff0c2min\u540e\u53d1\u73b06\u4e2a\u80f6\u56ca\u5f00\u59cb\u6563\u5f00\uff0c5min\u540e\u52a0\u5165300ml\u4ecb\u8d282\uff0c\u53730.01 N HCL+3%SDS\u6eb6\u6db2,\u6700\u7ec8\u4ecb\u8d28\u7ec4\u6210\u4e3a0.01 N HCL +1% SDS\u5373500,000 units\/L\u80c3\u86cb\u767d\u9176\u3002<\/p>\n

                      \"\u660e\u80f6\u80f6\u56ca\u4ea4\u8054\u95ee\u9898\u7684\u7814\u7a76\u601d\u8def\"<\/p>\n

                      \u968f\u540e\uff0c\u6574\u4e2aTier II\u65b9\u6cd5\u8fdb\u884c\u4e86\u5b8c\u6574\u7684\u65b9\u6cd5\u5b66\u9a8c\u8bc1\uff0c\u5305\u62ec\u7ebf\u6027\u3001\u4e13\u5c5e\u6027\u3001\u51c6\u786e\u5ea6\u3001\u91cd\u590d\u6027\u3001\u4e2d\u95f4\u7cbe\u5bc6\u5ea6\u3001\u5bf9\u7167\u54c1\u6eb6\u6db2\u548c\u4f9b\u8bd5\u54c1\u6eb6\u6db2\u7a33\u5b9a\u6027\u7b49\u3002<\/p>\n

                      \u4e94\u3001\u603b\u7ed3<\/span><\/strong><\/h1>\n

                      \u660e\u80f6\u80f6\u56ca\u4ea4\u8054\u5728\u80f6\u56ca\u5242\u5f00\u53d1\u4e2d\uff0c\u7279\u522b\u662f\u7a33\u5b9a\u6027\u8003\u5bdf\u4e2d\u7ecf\u9a8c\u9047\u5230\uff0c\u91c7\u7528\u5408\u7406\u7684\u7814\u7a76\u601d\u8def\u81f3\u5173\u91cd\u8981\uff0c\u4e2d\u56fd\u836f\u5178\u6eb6\u51fa\u5ea6\u901a\u5219\u4e2d\u6ca1\u6709\u89c4\u5b9a\u5982\u4f55\u8fdb\u884c\u7814\u7a76\u3002\u4f5c\u8005\u5efa\u8bae\uff0c\u5728\u6ce8\u518c\u7533\u62a5\u9636\u6bb5\u5e94\u8003\u8651\u8fdb\u884c\u5fc5\u8981\u7684\u8bf4\u660e\uff0c\u4ee5\u514d\u88ab\u53d1\u8865\u3002<\/p>\n

                      \u516d\u3001\u53c2\u8003\u6587\u732e<\/span><\/strong><\/span><\/h1>\n
                        \n
                      1. \n

                        Rampurna P. Gullapalli, Carolyn L.Mazzitelli.Gelatin and Non-Gelatin Capsule Dosage Forms.Journal of Pharmaceutical Sciences, Volume 106, Issue 6, June 2017, Pages 1453-1465<\/span><\/p>\n<\/li>\n

                      2. \n

                        Margareth R. C.Marques.Enzymes in the Dissolution Testing of Gelatin Capsules. AAPS Pharm Sci Tech, Vol. 15, No. 6, December 2014.1410-1416<\/span><\/p>\n<\/li>\n

                      3. \n

                        \u8c08\u9896, \u590f\u9e23, \u5218\u6625\u6656, \u7b49. \u80f6\u56ca\u4ea7\u751f\u4ea4\u8054\u53cd\u5e94\u7684\u7814\u7a76[J]. \u4eca\u65e5\u79d1\u82d1, 2010(13): 137<\/span><\/p>\n<\/li>\n

                      4. \n

                        \u5f20\u6dfc\uff0c\u6885\u6885\uff0c\u674e\u715c\uff0c\u9648\u60a6\uff0c\u6d2a\u5229\u5a05.\u660e\u80f6\u80f6\u56ca\u7684\u4ea4\u8054\u73b0\u8c61\u53ca\u5176\u5728\u4f53\u5916\u6eb6\u51fa\u8bd5\u9a8c\u4e2d\u7684\u7814\u7a76\u8fdb\u5c55[J]. \u4e2d\u56fd\u73b0\u4ee3\u5e94\u7528\u836f\u5b662018\u5e742\u6708\u7b2c35\u5377\u7b2c2\u671f.302-305<\/span><\/p>\n<\/li>\n

                      5. \n

                        USP <711> Dissolution<\/span><\/p>\n<\/li>\n

                      6. \n

                        GUZMAN M L,MARQUES M R, ME M E O, et al. Enzymatic activity in the presence of surfactants commonly used in dissolution media, Part 1: Pepsin [J]. Results Pharma Sci,2016(6): 15-19.<\/span><\/p>\n<\/li>\n

                      7. \n

                        GUNCHEVA M,STIPPLER E. Effect of four commonly used dissolution media surfactants on pancreatin proteolytic activity [J]. AAPS Pharmscitech, 2016, 18(4): 1402-1407.<\/span><\/p>\n<\/li>\n

                      8. \n

                        X.Song, Y.Cui,M.Xie, “Gelatin Capsule Shell Cross Linking,” Pharmaceutical Technology 35 (5) 62\u201368 (2011)<\/span> <\/p>\n


                        <\/p>\n<\/li>\n<\/ol>\n

                        —-END—-<\/span><\/p>\n


                        <\/p>\n

                        \n
                        \n

                        \u5f81\u7a3f\u542f\u4e8b<\/a>
                        <\/span><\/strong><\/p>\n


                        <\/p>\n

                        \u540c\u5199\u610f\u8bba\u575b\uff1a<\/span><\/strong><\/p>\n

                        \n

                        1.<\/span>\u7b2c91\u671f\u8bba\u575b\u4e28FDA\u4e13\u5bb6\u56e2\u9886\u822a\u65b0\u836f\u4e2d\u7f8e\u53cc\u62a5\u4e4b\u8def<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n


                        <\/p>\n

                        \"\u660e\u80f6\u80f6\u56ca\u4ea4\u8054\u95ee\u9898\u7684\u7814\u7a76\u601d\u8def\"<\/span><\/a><\/p>\n


                        <\/p>\n

                        \u662f\u4e00\u4e2a\u5f00\u653e\uff0c\u7531\u81ea\u613f\u8005\u7ec4\u6210\u7684\u56e2\u4f53\uff0c\u7531\u4ee5\u4e0b\u6210\u5458\u7ec4\u6210\uff1aVoyager88\uff0c\u96f7\u8bfa\u5c9b\uff0cHerman\uff0c\u6885\u5e0c\uff0c\u6587\u7af9\uff0cduke\uff0c\u5360\u5c0f\u5175\uff0c\u9526\u5fc3\u7ee3\u53e3\uff0c\u591a\u5df4\u80fa\uff0c\u745c\u513f\uff0c\u5b50\u708e\uff0c\u514b\u683c\u83ab\uff0cSophia \uff0c\u5076\u9635\u96e8\uff0c\u96f6\u4e0b274\u2103\uff0cHelen\uff0c\u7b49\u7b49\uff0cZMJ\uff0c\u6da6\u513f\uff0c\u4e91\u5377\u3001\u4e8c\u53cb\u6728\u3001\u7f8a\u7f8a\u3001wonger\u3001Jerry\u3001Admiral\u3001\u5723\u624b\u5c0f\u6bd2\u7269\u3001\u9b54\u9b3c\u6df1\u767d\u8272\u3001\u90ed\u5927\u4fa0\u3001\u8427\u6708\u3001\u6c22\u6c14\u53d1\u751f\u5668\u3001\u8c01\u3001\u8d1d\u58f3\u91cc\u7684\u4e7e\u5764\u3001Freesky\u548c\u66fe\u6587\u4eae\u3002\u6b22\u8fce\u6709\u5fd7\u4e4b\u58eb\u52a0\u5165\u6211\u4eec\u56e2\u961f\u3002\u6295\u7a3f\u3001\u5408\u4f5c\u3001\u52a0\u4e13\u4e1a\u7fa4\u8bf7\u52a0\u5fae\u4fe1437180999\uff0c\u4e8c\u5343\u4ebaQQ\u7fa422711855\u3002<\/span><\/p>\n


                        <\/p>\n

                        \u8d23\u4efb\u7f16\u8f91\uff1a\u96f7\u8bfa\u5c9b<\/span><\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

                        \u80f6\u56ca\u5242\u662f\u6307\u836f\u7269\u6216\u52a0\u6709\u8f85\u6599\u5145\u586b\u4e8e\u7a7a\u5fc3\u80f6\u56ca\u6216\u5bc6\u5c01\u4e8e\u8f6f\u8d28\u56ca\u6750\u4e2d\u7684\u56fa\u4f53\u5236\u5242\u3002\u6839\u636e\u80f6\u56ca\u7684\u6eb6\u89e3\u4e0e\u91ca\u653e\u7279\u6027\u53ef\u5206\u4e3a\u786c\u80f6\u56ca\u3001\u8f6f\u80f6 […]<\/p>\n","protected":false},"author":1,"featured_media":83918,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/83917"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=83917"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/83917\/revisions"}],"predecessor-version":[{"id":83929,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/83917\/revisions\/83929"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/83918"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=83917"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=83917"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=83917"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}