{"id":83930,"date":"2019-04-14T00:00:50","date_gmt":"2019-04-17T03:08:26","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/83930\/"},"modified":"2019-04-17T11:08:27","modified_gmt":"2019-04-17T03:08:27","slug":"0338f1cda6","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/83930\/","title":{"rendered":"\u5236\u836f\u516c\u53f8\u7684\u4e0b\u4e00\u4e2a\u6398\u91d1\u4e4b\u5730\uff1a\u53d8\u6784\u4f4d\u70b9\u8c03\u63a7allosteric modulator\u7684\u5f00\u53d1"},"content":{"rendered":"<div class=\"bpp-post-content\">\n<p><br  \/><\/p>\n<p><br  \/><\/p>\n<p><span style=\"font-size: 14px;\">\u672c\u6587\u8f6c\u81ea\u5316\u5b66\u52a0\uff0c\u8f6c\u8f7d\u5df2\u83b7\u6388\u6743\u3002<\/span><\/p>\n<p><span style=\"font-size: 14px;\"><br  \/><\/span><\/p>\n<section style=\"max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;line-height: 27.2px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);box-sizing: 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15px 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u5176\u5b9e\u5927\u81ea\u7136\u8fdb\u5316\u8fc7\u7a0b\u4e3a\u8c03\u8282\u86cb\u767d\u529f\u80fd\u6784\u5efa\u4e86\u4e00\u5957\u975e\u5e38\u7cbe\u5bc6\u800c\u6709\u6548\u7684\u8c03\u63a7\u7cfb\u7edf\u3002<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u8fd9\u4e00\u8c03\u63a7\u7cfb\u7edf\u7684\u4e2d\u5fc3\u662f\u86cb\u767d\u4e0a\u79f0\u4e3a\u8c03\u63a7\u70ed\u70b9\u7684\u4e00\u7cfb\u5217\u53d8\u6784\u4f4d\u70b9\uff08Allosteric&nbsp;sites\uff09\u3002<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u8fd9\u4e9b\u53d8\u6784\u4f4d\u70b9\u901a\u5e38\u8fdc\u79bb\u86cb\u767d\u7684\u6d3b\u6027\u4f4d\u70b9\uff0c\u5b83\u4eec\u4e0d\u4f46\u5bf9\u86cb\u767d\u529f\u80fd\u975e\u5e38\u91cd\u8981\uff0c\u800c\u4e14\u5177\u5907\u72ec\u7279\u7684\u7ed3\u6784\u7279\u5f81\u3002<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u56e0\u6b64\uff0c\u9776\u5411\u8c03\u63a7\u70ed\u70b9\u7684\u5c0f\u5206\u5b50\u836f\u7269\u4f1a\u5177\u5907\u66f4\u9ad8\u7684\u9009\u62e9\u6027\u3001\u5b89\u5168\u6027\u548c\u6548\u529b\uff0c\u751a\u81f3\u4e5f\u6709\u53ef\u80fd\u653b\u514b\u4e00\u4e9b\u96be\u6210\u836f\u9776\u70b9\uff08tough-to-drug&nbsp;targets\uff09\u3002<\/span><span style=\"font-size: 16px;max-width: 100%;line-height: 24px;font-family: \u5b8b\u4f53;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/span><\/p>\n<p style=\"margin: 15px 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u548c\u4f20\u7edf\u7684\u9776\u5411\u836f\u7269\u8bbe\u8ba1\u76f8\u6bd4\uff0c\u9488\u5bf9\u53d8\u6784\u4f4d\u70b9\u8c03\u63a7\u7684\u836f\u7269\u5f00\u53d1\u8fc7\u7a0b\u66f4\u5177\u6709\u6311\u6218\u6027\u4e0e\u5f00\u62d3\u6027\u3002<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u8fd1\u65e5\u7f8e\u56fd\u5316\u5b66\u5b66\u4f1aC&amp;EN\u6742\u5fd7\u5c31\u5bf9\u4e8e\u53d8\u6784\u4f4d\u70b9\u8c03\u63a7\u836f\u7269\u5f00\u53d1\u9886\u57df\u505a\u4e86\u5c01\u9762\u4e13\u9898\u62a5\u9053<\/span><span style=\"max-width: 100%;font-size: 12px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><sup style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: \u5b8b\u4f53;line-height: 15px;vertical-align: super;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;box-sizing: border-box !important;overflow-wrap: break-word !important;\">[<\/span><\/sup><sup style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: Helvetica;line-height: 15px;vertical-align: super;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;box-sizing: border-box !important;overflow-wrap: break-word !important;\">1<\/span><\/sup><sup style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: \u5b8b\u4f53;line-height: 15px;vertical-align: super;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;box-sizing: border-box !important;overflow-wrap: break-word !important;\">]<\/span><\/sup><\/span><span style=\"max-width: 100%;line-height: 24px;font-size: 16px;font-family: \u5b8b\u4f53;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u3002<\/span><\/p>\n<p style=\"margin: 15px 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;color: rgb(136, 136, 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!important;\"><\/span><\/p>\n<p style=\"margin: 15px 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u4e0b\u9762\u4f1a\u5bf9\u4e0a\u8ff0\u516c\u53f8\u7684\u53d8\u6784\u6291\u5236\u5242\u76f8\u5173\u4ea7\u54c1\u7ba1\u7ebf\u3001\u7279\u8272\u9776\u70b9\u9886\u57df\u6216\u6280\u672f\u5e73\u53f0\u505a\u7b80\u8981\u5206\u6790\u3002<\/span><span style=\"max-width: 100%;line-height: 24px;font-size: 16px;font-family: \u5b8b\u4f53;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/span><\/p>\n<p style=\"margin: 15px 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u8bb2\u5230\u53d8\u6784\u6291\u5236\u5242\u836f\u7269\u5f00\u53d1\uff0c\u5fc5\u987b\u8981\u8bf4\u4e00\u8bf4\u78f7\u9178\u9176\uff08phosphatase\uff09\u65b9\u9762\u7684\u7814\u7a76\u3002<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u78f7\u9178\u9176\u5bf9\u8bb8\u591a\u751f\u7269\u5b66\u529f\u80fd\u81f3\u5173\u91cd\u8981\uff0c\u56e0\u4e3a\u78f7\u9178\u5316\uff08\u901a\u8fc7\u86cb\u767d\u6fc0\u9176\uff09\u548c\u53bb\u78f7\u9178\u5316\uff08\u901a\u8fc7\u78f7\u9178\u9176\uff09\u5728\u7ec6\u80de\u8c03\u8282\u548c\u4fe1\u53f7\u4f20\u5bfc\u4e2d\u8d77\u7740\u81f3\u5173\u91cd\u8981\u4f5c\u7528\uff0c\u4f46\u662f\u9776\u5411\u78f7\u9178\u9176\u7684\u836f\u7269\u5374\u662f\u96be\u4ee5\u5bfb\u89c5\u3002<\/span><\/p>\n<p style=\"margin: 15px 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;color: rgb(136, 136, 136);\"><\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u7531\u4e8e\u78f7\u9178\u9176\u5e26\u6709\u7535\u8377\uff0c\u4e0e\u4e4b\u7ed3\u5408\u7684\u836f\u7269\u4e00\u822c\u5177\u6709\u5f88\u5f3a\u7684\u6781\u6027\u6216\u8005\u4e5f\u5177\u6709\u7535\u8377\uff0c\u8fd9\u5c31\u5bfc\u81f4\u836f\u7269\u53ef\u80fd\u5177\u6709\u5f88\u5dee\u7684\u751f\u7269\u5229\u7528\u5ea6\u4e0e\u900f\u819c\u6548\u679c\uff0c\u8fd9\u6781\u5927\u7684\u5f71\u54cd\u4e86\u836f\u7269\u836f\u6548\u7684\u53d1\u6325\u3002<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u5982\u4f55\u89e3\u51b3\u8fd9\u4e9b\u96be\u9898\u5c06\u662f\u9700\u8981\u9762\u4e34\u7684\u73b0\u5b9e\u6311\u6218\u3002<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">SHP2\u4e5f\u5c5e\u4e8e\u86cb\u767d\u916a\u6c28\u9178\u78f7\u9178\u9176PTP\u86cb\u767d\u5bb6\u65cf\uff0c\u4e0e\u4e73\u817a\u764c\u3001\u80ba\u764c\u7b49\u591a\u79cd\u764c\u75c7\u7684\u53d1\u751f\u5bc6\u5207\u76f8\u5173\uff0c\u6b64\u5916\uff0cSHP2\u8fd8\u8c03\u8282PD-1\u4ecb\u5bfc\u7684\u4fe1\u53f7\u8f6c\u5bfc\uff0c\u5e76\u53c2\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u901a\u8def\u7684\u8c03\u8282\u3002<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">Novartis\u516c\u53f8\u7814\u53d1\u7684\u53d8\u6784SHP2\u6291\u5236\u5242<\/span><span style=\"max-width: 100%;font-size: 12px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><sup style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: \u5b8b\u4f53;line-height: 15px;vertical-align: super;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;box-sizing: border-box !important;overflow-wrap: break-word !important;\">[<\/span><\/sup><sup style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: Helvetica;line-height: 15px;vertical-align: super;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;box-sizing: border-box !important;overflow-wrap: break-word !important;\">2<\/span><\/sup><sup style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: \u5b8b\u4f53;line-height: 15px;vertical-align: super;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;box-sizing: border-box !important;overflow-wrap: break-word !important;\">]<\/span><\/sup><\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;line-height: 24px;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\uff0c<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u662f\u7531\u5148\u5bfc\u5316\u5408\u7269SHP099\u53d1\u5c55\u800c\u6765\uff0c\u76ee\u524d\u5df2\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8cI\u671f\u3002<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;line-height: 24px;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/span><\/p>\n<p style=\"margin: 15px 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;color: rgb(136, 136, 136);\"><br  \/><\/span><\/p>\n<p style=\"margin: 15px 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;widows: 1;text-align: center;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"      style=\"box-shadow: rgb(170, 170, 170) 0px 0px 14px 0px;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 513px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/3-1555470506.jpg\" alt=\"\u5236\u836f\u516c\u53f8\u7684\u4e0b\u4e00\u4e2a\u6398\u91d1\u4e4b\u5730\uff1a\u53d8\u6784\u4f4d\u70b9\u8c03\u63a7allosteric modulator\u7684\u5f00\u53d1\" title=\"\u5236\u836f\u516c\u53f8\u7684\u4e0b\u4e00\u4e2a\u6398\u91d1\u4e4b\u5730\uff1a\u53d8\u6784\u4f4d\u70b9\u8c03\u63a7allosteric modulator\u7684\u5f00\u53d1\"  \/><\/p>\n<p style=\"margin: 15px 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;color: rgb(136, 136, 136);\"><br  \/><\/span><\/p>\n<p style=\"margin: 15px 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">2018\u5e747\u6708\uff0c\u8d5b\u8bfa\u83f2\u548c\u6e7e\u533a\u751f\u7269\u6280\u672f\u516c\u53f8Revolution Medicines\u5ba3\u5e03\u8fbe\u6210\u4e86\u4e00\u9879\u72ec\u5bb6\u5168\u7403\u5408\u4f5c\u4f19\u4f34\u5173\u7cfb\uff0c\u65e8\u5728\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u57fa\u4e8eSHP2\u751f\u7269\u5b66\u7684\u9776\u5411\u7597\u6cd5<\/span><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><sup style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;font-family: \u5b8b\u4f53;line-height: 24px;vertical-align: super;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;box-sizing: border-box !important;overflow-wrap: break-word !important;\">[<\/span><\/sup><sup style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;font-family: Helvetica;line-height: 24px;vertical-align: super;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;box-sizing: border-box !important;overflow-wrap: break-word !important;\">3<\/span><\/sup><sup style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;font-family: \u5b8b\u4f53;line-height: 24px;vertical-align: super;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;box-sizing: border-box !important;overflow-wrap: break-word !important;\">]<\/span><\/sup><span style=\"line-height: 24px;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\uff0c<\/span><\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u7528\u4e8e\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u548c\u5176\u4ed6\u643a\u5e26\u67d0\u4e9b\u7a81\u53d8\u7684\u764c\u75c7\u60a3\u8005\u3002<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u6839\u636e\u534f\u8bae\uff0cRevolution\u5c06\u83b7\u5f975000\u4e07\u7f8e\u5143\u7684\u524d\u671f\u8d39\u7528\u3002<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">Revolution&nbsp;Medicines\u516c\u53f8\u7814\u53d1\u7684SHP2\u53d8\u6784\u6291\u5236\u5242RMC-4630\uff0c\u4e5f\u662fSHP099\u7684\u7c7b\u4f3c\u7269\uff0c\u5bf9\u591a\u79cd\u80bf\u7624\uff0c\u5982\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u751f\u957f\u5177\u6709\u6291\u5236\u4f5c\u7528\u3002<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u76ee\u524d\u8be5\u836f\u5904\u4e8e\u4e34\u5e8a\u8bd5\u9a8cI\u671f\u3002<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;line-height: 24px;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/span><\/p>\n<p style=\"margin: 15px 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u53bb\u5e747\u6708\uff0c\u4f4d\u4e8e\u9a6c\u8428\u8bf8\u585e\u5dde\u7684\u751f\u7269\u6280\u672fHotSpot Therapeutics\u516c\u53f8<\/span><span style=\"max-width: 100%;font-size: 16px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><sup style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;font-family: \u5b8b\u4f53;line-height: 24px;vertical-align: super;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;box-sizing: border-box !important;overflow-wrap: break-word !important;\">[<\/span><\/sup><sup style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;font-family: Helvetica;line-height: 24px;vertical-align: super;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;box-sizing: border-box !important;overflow-wrap: break-word !important;\">4<\/span><\/sup><sup style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 16px;font-family: \u5b8b\u4f53;line-height: 24px;vertical-align: super;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;box-sizing: border-box !important;overflow-wrap: break-word !important;\">]<\/span><\/sup><\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u5df2\u5b8c\u62104500\u4e07\u7f8e\u5143\u7684A\u8f6e\u878d\u8d44\uff0c\u878d\u8d44\u7531Atlas&nbsp;Venture&nbsp;\u548c&nbsp;Sofinnova&nbsp;Partners&nbsp;\u5171\u540c\u9886\u6295\u3002<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">HotSpot\u516c\u53f8\u79f0\u5df2\u7ecf\u5728\u8d85\u8fc7100\u79cd\u86cb\u767d\u4e2d\u53d1\u73b0\u4e86\u8c03\u63a7\u70ed\u70b9\uff0c\u8be5\u516c\u53f8\u836f\u7269\u7814\u53d1\u7ba1\u7ebf\u5305\u62ec\u9776\u5411PKC-theta&nbsp;\u548cS6\u86cb\u767d\u6fc0\u9176\u7b49\u9776\u70b9\u7684\u521b\u65b0\u5316\u5408\u7269\u3002<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u5176\u4e2dS6\u86cb\u767d\u6fc0\u9176\uff08S6K\uff09\u662f\u8c03\u8282\u809d\u810f\u80f0\u5c9b\u7d20\u654f\u611f\u6027\u548c\u7ebf\u7c92\u4f53\u529f\u80fd\u7684\u4ee3\u8c22\u9176\uff0c\u5b83\u662f\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u3001\u4ee3\u8c22\u7c7b\u75be\u75c5\u548c\u7ebf\u7c92\u4f53\u75be\u75c5\u7684\u91cd\u8981\u9776\u70b9\u3002<\/span><span style=\"font-size: 16px;font-family: \u5b8b\u4f53;line-height: 24px;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/span><\/p>\n<p style=\"margin: 15px 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">HotSpot\u516c\u53f8\u8054\u5408\u521b\u59cb\u4eba\u517c\u9996\u5e2d\u6267\u884c\u5b98Jonathan&nbsp;Montagu\u66fe\u8fd9\u6837\u63cf\u8ff0\uff0cHotSpot\u516c\u53f8\u9776\u5411\u7684\u662f\u86cb\u767d\u7684\u5929\u7136\u8c03\u63a7\u4f4d\u70b9\u3002<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u8fd9\u4e00\u7b56\u7565\u8ba9\u6211\u4eec\u80fd\u591f\u5f00\u53d1\u4f7f\u7528\u540c\u6837\u8c03\u63a7\u673a\u5236\u7684\u521b\u65b0\u836f\u7269\uff0c\u5b83\u4eec\u5177\u5907\u540c\u6837\u7684\u7cbe\u786e\u6027\u548c\u6548\u529b\u3002<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u8c03\u63a7\u70ed\u70b9\u5728\u836f\u7269\u7814\u53d1\u8fc7\u7a0b\u4e2d\u8fd8\u672a\u88ab\u5b8c\u5168\u5f00\u53d1\uff0c\u8fd9\u4ee3\u8868\u7740\u5728\u591a\u79cd\u75be\u75c5\u9886\u57df\u4e2d\u53d1\u73b0first-in-class&nbsp;\u836f\u7269\u7684\u91cd\u5927\u673a\u9047\u3002<\/span><span style=\"font-size: 16px;max-width: 100%;line-height: 24px;font-family: \u5b8b\u4f53;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/span><\/p>\n<p style=\"margin: 15px 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;widows: 1;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;color: rgb(136, 136, 136);\"><br  \/><\/span><\/p>\n<p style=\"margin: 15px 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;widows: 1;text-align: center;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"      style=\"box-shadow: rgb(170, 170, 170) 0px 0px 14px 0px;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 626px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/10-1555470506.jpg\" alt=\"\u5236\u836f\u516c\u53f8\u7684\u4e0b\u4e00\u4e2a\u6398\u91d1\u4e4b\u5730\uff1a\u53d8\u6784\u4f4d\u70b9\u8c03\u63a7allosteric modulator\u7684\u5f00\u53d1\" title=\"\u5236\u836f\u516c\u53f8\u7684\u4e0b\u4e00\u4e2a\u6398\u91d1\u4e4b\u5730\uff1a\u53d8\u6784\u4f4d\u70b9\u8c03\u63a7allosteric modulator\u7684\u5f00\u53d1\"  \/><\/p>\n<p style=\"margin: 15px 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;widows: 1;text-align: center;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: Arial;line-height: 21px;background: rgb(249, 249, 249);\">&nbsp;<\/span><strong style=\"max-width: 100%;font-size: 16px;text-indent: 0em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;font-family: \u5b8b\u4f53;line-height: 21px;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;box-sizing: border-box !important;overflow-wrap: break-word !important;\">S6K\u6676\u4f53\u7ed3\u6784\uff08<\/span><\/strong><strong style=\"max-width: 100%;font-size: 16px;text-indent: 0em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;font-family: Helvetica;line-height: 21px;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;box-sizing: border-box !important;overflow-wrap: break-word !important;\">HotSpot<\/span><\/strong><strong style=\"max-width: 100%;font-size: 16px;text-indent: 0em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;line-height: 21px;font-family: \u5b8b\u4f53;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u6b63<\/span><\/strong><strong style=\"max-width: 100%;font-size: 16px;text-indent: 0em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;line-height: 21px;font-family: \u5b8b\u4f53;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5728\u9488\u5bf9<\/span><\/strong><strong style=\"max-width: 100%;font-size: 16px;text-indent: 0em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;line-height: 21px;font-family: \u5b8b\u4f53;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u8fd9\u4e00<\/span><\/strong><strong style=\"max-width: 100%;font-size: 16px;text-indent: 0em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;line-height: 21px;font-family: \u5b8b\u4f53;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u9776\u70b9<\/span><\/strong><strong style=\"max-width: 100%;font-size: 16px;text-indent: 0em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;line-height: 21px;font-family: \u5b8b\u4f53;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5f00\u53d1<\/span><\/strong><strong style=\"max-width: 100%;font-size: 16px;text-indent: 0em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;line-height: 21px;font-family: \u5b8b\u4f53;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u53d8\u6784\u6291\u5236\u5242<\/span><\/strong><strong style=\"max-width: 100%;font-size: 16px;text-indent: 0em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;line-height: 21px;font-family: \u5b8b\u4f53;background-image: initial;background-position: initial;background-size: initial;background-repeat: initial;background-attachment: initial;background-origin: initial;background-clip: initial;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\uff09<\/span><\/strong><\/span><\/p>\n<h3 style=\"margin: 15px 8px;max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;widows: 1;line-height: 1.75em;background: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u5728\u7ade\u4e89\u5f02\u5e38\u6fc0\u70c8\u7684\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u9886\u57df\uff0cNimbus&nbsp;Therapeutics\u516c\u53f8\u8054\u5408\u8ba1\u7b97\u5316\u5b66\u9886\u57df\u7684\u5408\u4f5c\u4f19\u4f34Schr\u00f6dinger\u516c\u53f8(\u8be5\u516c\u53f8\u7684\u72ec\u7279\u8ba1\u7b97\u6a21\u62df\u5e73\u53f0\u88ab\u4f17\u591a\u4ece\u4e8b\u53d8\u6784\u8c03\u5236\u7684\u751f\u7269\u6280\u672f\u516c\u53f8\u4f7f\u7528)&nbsp;\u5f00\u53d1\u4e86\u4e00\u79cd\u4e59\u9170\u8f85\u9176A\u7fa7\u5316\u9176\uff08ACC\uff09\u7684\u53d8\u6784\u6291\u5236\u5242\u3002<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">2016\u5e744\u6708\uff0c\u5409\u5229\u5fb7\u6536\u8d2dNimbus&nbsp;Therapeutics\u5168\u8d44\u5b50\u516c\u53f8Nimbus&nbsp;Apollo\u53ca\u5176\u4e59\u9170\u8f85\u9176A\u7fa7\u5316\u9176\uff08ACC\uff09\u6291\u5236\u5242\u9879\u76ee\uff0c\u603b\u4ea4\u6613\u91d1\u989d\u8fbe12\u4ebf\u7f8e\u5143\uff08\u5176\u4e2d\u5305\u62ec4\u4ebf\u7f8e\u5143\u9996\u4ed8\u30018\u4ebf\u7f8e\u5143\u6f5c\u5728\u91cc\u7a0b\u91d1\uff09\u3002<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u8be5\u5316\u5408\u7269\u76ee\u524d\u5df2\u5904\u4e8e\u4e34\u5e8aII\u671f\u9636\u6bb5\u3002<\/span><span style=\"max-width: 100%;line-height: 24px;font-family: \u5b8b\u4f53;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/span><\/h3>\n<p><span style=\"font-size: 15px;color: rgb(136, 136, 136);\"><br  \/><\/span><\/p>\n<p style=\"margin: 15px 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;widows: 1;text-align: center;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"      style=\"box-shadow: rgb(170, 170, 170) 0px 0px 14px 0px;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 560px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/6-1555470507.jpg\" alt=\"\u5236\u836f\u516c\u53f8\u7684\u4e0b\u4e00\u4e2a\u6398\u91d1\u4e4b\u5730\uff1a\u53d8\u6784\u4f4d\u70b9\u8c03\u63a7allosteric modulator\u7684\u5f00\u53d1\" title=\"\u5236\u836f\u516c\u53f8\u7684\u4e0b\u4e00\u4e2a\u6398\u91d1\u4e4b\u5730\uff1a\u53d8\u6784\u4f4d\u70b9\u8c03\u63a7allosteric modulator\u7684\u5f00\u53d1\"  \/><\/p>\n<p style=\"margin: 15px 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;widows: 1;line-height: 1.75em;background: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;color: rgb(136, 136, 136);\"><br  \/><\/span><\/p>\n<p style=\"margin: 15px 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;widows: 1;line-height: 1.75em;background: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u53bb\u5e7412\u670820\u65e5\uff0c\u540c\u6837\u4f4d\u4e8e\u9a6c\u8428\u8bf8\u585e\u5dde\u7684\u751f\u7269\u5236\u836f\u521d\u521b\u516c\u53f8Relay Therapeutics\u5ba3\u5e03\u5b8c\u62104\u4ebf\u7f8e\u5143C\u8f6e\u878d\u8d44<\/span><span style=\"max-width: 100%;font-size: 12px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><sup style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: \u5b8b\u4f53;line-height: 15px;vertical-align: super;box-sizing: border-box !important;overflow-wrap: break-word !important;\">[<\/span><\/sup><sup style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: Helvetica;line-height: 15px;vertical-align: super;box-sizing: border-box !important;overflow-wrap: break-word !important;\">5<\/span><\/sup><sup style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: \u5b8b\u4f53;line-height: 15px;vertical-align: super;box-sizing: border-box !important;overflow-wrap: break-word !important;\">]<\/span><\/sup><\/span><span style=\"font-size: 16px;max-width: 100%;line-height: 24px;font-family: \u5b8b\u4f53;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u3002<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u8be5\u516c\u53f8\u65e8\u5728\u901a\u8fc7\u5efa\u7acb\u4e00\u4e2a\u72ec\u7279\u5f00\u53d1\u5e73\u53f0\uff0c\u4ee5\u86cb\u767d\u8d28\u52a8\u6001\u7ed3\u6784\u4e3a\u57fa\u77f3\u5bfb\u627e\u5bf9\u60a3\u8005\u5177\u6709\u53d8\u9769\u6027\u5f71\u54cd\u7684\u836f\u7269\u3002<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u8be5\u5e73\u53f0\uff08protein-motion-based&nbsp;platform\uff09\u6838\u5fc3\u5173\u6ce8\u201c\u5982\u4f55\u7406\u89e3\u86cb\u767d\u8d28\u7684\u6784\u8c61\u4e0e\u529f\u80fd\u7684\u5173\u7cfb\u201d\u3002<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u5148\u524d\u7684\u6210\u50cf\u86cb\u767d\u8d28\u65b9\u6cd5\u4ec5\u9650\u4e8e\u9759\u6001\u56fe\u50cf\uff0c\u4f46Relay&nbsp;Therapeutics\u8de8\u8d8a\u7ed3\u6784\u751f\u7269\u5b66\u3001\u751f\u7269\u7269\u7406\u5b66\u3001\u5316\u5b66\u548c\u751f\u7269\u5b66\u7b49\u9886\u57df\uff0c\u5c06\u8ba1\u7b97\u673a\u80fd\u529b\u548c\u5c16\u7aef\u5b9e\u9a8c\u65b9\u6cd5\u6574\u5408\u8d77\u6765\uff0c\u9996\u6b21\u9610\u660e\u4e86\u86cb\u767d\u8d28\u7684\u5b8c\u5168\u6d41\u52a8\u6027\uff0c\u5e76\u63d0\u4f9b\u4e86\u201c\u5173\u4e8e\u86cb\u767d\u8d28\u6784\u8c61\u7684\u52a8\u6001\u6027\u8d28\u5982\u4f55\u8c03\u8282\u529f\u80fd\u201d\u7684\u5173\u952e\u89c1\u89e3\u3002<\/span><\/p>\n<p style=\"margin: 15px 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;widows: 1;line-height: 1.75em;background: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;color: rgb(136, 136, 136);\"><\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">Relay&nbsp;Therapeutics\u901a\u8fc7\u5173\u6ce8\u5fae\u5999\u8c03\u8282\u86cb\u767d\u8d28\u6784\u8c61\u53ca\u5176\u53d8\u6784\u4f4d\u70b9\uff0c\u4e3a\u60a3\u8005\u5f00\u53d1\u65b0\u7684\u7597\u6cd5\u3002<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">Relay&nbsp;Therapeutics\u7684\u603b\u88c1\u517c\u9996\u5e2d\u6267\u884c\u5b98Sanjiv&nbsp;Patel\u535a\u58eb\u8fd9\u6837\u63cf\u8ff0\uff0c\u6211\u4eec\u6b63\u5904\u4e8e\u836f\u7269\u53d1\u73b0\u6f14\u53d8\u7684\u72ec\u7279\u65f6\u523b\uff0c\u6211\u4eec\u53ef\u5c06\u5c16\u7aef\u5b9e\u9a8c\u548c\u8ba1\u7b97\u5de5\u5177\u6574\u5408\u8d77\u6765\uff0c\u89e3\u51b3\u4ee5\u524d\u4e0d\u53ef\u9776\u5411\u7684\u86cb\u767d\u8d28\u9776\u6807\uff0c\u8fd9\u5145\u5206\u9a8c\u8bc1\u4e86\u6211\u4eec\u5e73\u53f0\u62e5\u6709\u521b\u9020\u7a81\u7834\u6027\u7597\u6cd5\u4ee5\u5e94\u5bf9\u5404\u79cd\u75be\u75c5\u7684\u6f5c\u529b\u3002<\/span><span style=\"font-size: 16px;max-width: 100%;line-height: 24px;font-family: \u5b8b\u4f53;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/span><\/p>\n<p style=\"margin: 15px 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;widows: 1;line-height: 1.75em;background: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;color: rgb(136, 136, 136);\"><br  \/><\/span><\/p>\n<p style=\"margin: 15px 8px;max-width: 100%;min-height: 1em;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;widows: 1;text-align: center;line-height: 1.75em;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"\"      style=\"box-shadow: rgb(170, 170, 170) 0px 0px 14px 0px;box-sizing: border-box !important;overflow-wrap: break-word !important;width: 677px !important;visibility: visible !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/7-1555470507.jpg\" alt=\"\u5236\u836f\u516c\u53f8\u7684\u4e0b\u4e00\u4e2a\u6398\u91d1\u4e4b\u5730\uff1a\u53d8\u6784\u4f4d\u70b9\u8c03\u63a7allosteric modulator\u7684\u5f00\u53d1\" title=\"\u5236\u836f\u516c\u53f8\u7684\u4e0b\u4e00\u4e2a\u6398\u91d1\u4e4b\u5730\uff1a\u53d8\u6784\u4f4d\u70b9\u8c03\u63a7allosteric modulator\u7684\u5f00\u53d1\"  \/><\/p>\n<h3 style=\"margin: 15px 8px;max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;widows: 1;text-align: center;line-height: 1.75em;background: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: Helvetica;box-sizing: border-box !important;overflow-wrap: break-word !important;\">Relay Therapeutics<span style=\"max-width: 100%;font-family: \u5b8b\u4f53;\">\u6280\u672f<\/span><\/span><\/strong><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-family: \u5b8b\u4f53;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u5e73\u53f0\u6d1e\u5bdf\u86cb\u767d\u8d28\u7684\u5145\u5206\u52a8\u6001\u5e73\u8861<\/span><\/strong><\/span><\/h3>\n<h3 style=\"margin: 15px 8px;max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;widows: 1;line-height: 1.75em;background: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u53e6\u4e00\u5bb6\u4f4d\u4e8e\u5723\u5730\u4e9a\u54e5\u7684Vividion&nbsp;Therapeutics\u516c\u53f8\u5219\u5b8c\u5168\u91c7\u7528\u4e0d\u540c\u7684\u65b9\u6cd5\u6765\u5bfb\u627e\u6b63\u5728\u86cb\u767d\u8d28\u4e2d\u7684\u9690\u85cf\u53e3\u888b\u3002<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u5728\u6d3b\u7ec6\u80de\u4e0a\u6dcb\u6d17\u5316\u5b66\u63a2\u9488\uff0c\u7136\u540e\u5bfb\u627e\u80fd\u4e0e\u86cb\u767d\u8d28\u8868\u9762\u4e0a\u534a\u80f1\u6c28\u9178\u7ed3\u5408\u7684\u63a2\u9488\u3002<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">Vividion\u6784\u5efa\u7684\u836f\u7269\u7814\u53d1\u5e73\u53f0\u80fd\u591f\u52a0\u5feb\u836f\u7269\u7814\u53d1\u901f\u5ea6\uff0c\u6269\u5c55\u53ef\u6210\u836f\u7684\u86cb\u767d\u7ec4\u8303\u56f4\uff0c\u5e76\u4e14\u653b\u514b\u9ad8\u96be\u5ea6\u9776\u70b9\u3002<\/span><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u53bb\u5e743\u6708Vividion&nbsp;Therapeutics\u516c\u53f8\u4e5f\u5ba3\u5e03\u4e0eCelgene\uff08\u65b0\u57fa\uff09\u516c\u53f8\u8fbe\u6210\u6218\u7565\u7814\u53d1\u5408\u4f5c\u534f\u8bae\uff0c\u7740\u91cd\u5229\u7528Vividion\u7684\u836f\u7269\u5f00\u53d1\u5e73\u53f0\u6765\u5f00\u53d1\u9776\u5411\u764c\u75c7\u3001\u708e\u75c7\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u521b\u65b0\u5c0f\u5206\u5b50\u836f\u7269\u3002<\/span><span style=\"font-family: \u5b8b\u4f53;line-height: 24px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/span><\/h3>\n<h3 style=\"margin: 15px 8px;max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;text-indent: 0em;white-space: normal;widows: 1;line-height: 1.75em;background: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 15px;color: rgb(136, 136, 136);\">\u867d\u7136\u672a\u6765\u53d8\u6784\u8c03\u63a7\u836f\u7269\u5f00\u53d1\u7684\u9053\u8def\u4e0a\u8fd8\u6709\u91cd\u91cd\u969c\u788d\u548c\u8bf8\u591a\u4e0d\u786e\u5b9a\u56e0\u7d20\uff0c\u4f46\u7531\u4e8e\u53d8\u6784\u8c03\u63a7\u836f\u7269\u7684\u9ad8\u9009\u62e9\u6027\u4ee5\u53ca\u901a\u8fc7\u53d8\u6784\u8c03\u63a7\u80fd\u591f\u6269\u5927\u6210\u836f\u7a7a\u95f4\u7684\u5de8\u5927\u6f5c\u529b\uff0c\u8fd9\u4e00\u9886\u57df\u5728\u672a\u6765\u4ecd\u5c06\u53d7\u5230\u4f17\u591a\u6295\u8d44\u8005\u7684\u6301\u7eed\u70ed\u6367\u3002<\/span><span style=\"font-family: \u5b8b\u4f53;line-height: 24px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/span><\/h3>\n<h3 style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);line-height: 1.5em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"font-size: 14px;\"><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u53c2\u8003\u6587\u732e<\/span><\/strong><strong style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/span><\/strong><\/span><\/h3>\n<h3 style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);line-height: 1.5em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">1.&nbsp;MARCH&nbsp;10,&nbsp;2019&nbsp;|&nbsp;CEN.ACS.ORG&nbsp;|&nbsp;C&amp;EN\uff1b<\/span><\/h3>\n<h3 style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);line-height: 1.5em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">2.&nbsp;doi:10.1038\/nature18621\uff1b<\/span><\/h3>\n<h3 style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);line-height: 1.5em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">3.&nbsp;JULY&nbsp;18,&nbsp;2018&nbsp;|&nbsp;CEN.ACS.ORG&nbsp;|&nbsp;C&amp;EN\uff1b<\/span><\/h3>\n<h3 style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);line-height: 1.5em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">4.&nbsp;HotSpot Therapeutics\u5b98\u7f51;<\/span><\/h3>\n<h3 style=\"margin-right: 8px;margin-left: 8px;max-width: 100%;font-variant-numeric: normal;font-variant-east-asian: normal;letter-spacing: 0.544px;white-space: normal;widows: 1;background-color: rgb(255, 255, 255);line-height: 1.5em;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;color: rgb(136, 136, 136);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">5.&nbsp;DECEMBER 20, 2018| CEN.ACS.ORG | C&amp;EN.<\/span><span style=\"max-width: 100%;font-size: 12px;color: rgb(136, 136, 136);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><\/span><\/h3>\n<p><span style=\"max-width: 100%;color: rgb(136, 136, 136);font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/span><\/p>\n<p style=\"white-space: normal;text-align: center;box-sizing: border-box;\"><span style=\"background: none 0% 0% \/ auto repeat scroll padding-box border-box rgb(255, 255, 255);box-sizing: border-box;color: rgb(46, 48, 51);font-family: \u5b8b\u4f53;font-size: 18px;line-height: 24px;max-width: 100%;overflow-wrap: break-word;\">&#8212;-END&#8212;-<\/span><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);line-height: 27.2px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<section style=\"white-space: normal;max-width: 677px;box-sizing: border-box;background-color: rgb(255, 255, 255);font-size: 16px;font-family: \u5fae\u8f6f\u96c5\u9ed1;letter-spacing: 0.54px;overflow-wrap: break-word !important;\">\n<section style=\"margin-right: 3px;margin-left: 3px;padding: 20px;max-width: 677px;box-sizing: border-box;background-color: rgb(254, 254, 254);border-color: rgb(210, 150, 20);box-shadow: rgb(210, 150, 20) 0px 0px 4px;overflow-wrap: break-word !important;\">\n<p style=\"max-width: 631px;box-sizing: border-box;min-height: 18px;color: rgb(210, 150, 20);font-weight: 700;min-width: 1px;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;letter-spacing: 0.54px;color: rgb(51, 51, 51);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(214, 168, 65);overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzI5ODI5NDE2OA==&amp;mid=2247500514&amp;idx=2&amp;sn=f8e95070eee110013824130e5550de62&amp;scene=21#wechat_redirect\" target=\"_blank\" >\u5f81\u7a3f\u542f\u4e8b<\/a><br  \/><\/span><\/strong><\/p>\n<p style=\"max-width: 631px;box-sizing: border-box;min-height: 18px;color: rgb(210, 150, 20);font-weight: 700;min-width: 1px;overflow-wrap: break-word !important;\"><br  \/><\/p>\n<p style=\"max-width: 631px;box-sizing: border-box;min-height: 18px;color: rgb(210, 150, 20);font-weight: 700;min-width: 1px;overflow-wrap: break-word !important;\"><strong style=\"max-width: 100%;box-sizing: border-box;letter-spacing: 0.54px;color: rgb(51, 51, 51);overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;box-sizing: border-box;color: rgb(214, 168, 65);overflow-wrap: break-word !important;\">\u540c\u5199\u610f\u8bba\u575b\uff1a<\/span><\/strong><\/p>\n<section style=\"margin-top: 10px;margin-bottom: 10px;max-width: 631px;box-sizing: border-box;border-color: rgb(210, 150, 20);overflow-wrap: break-word !important;\">\n<p style=\"margin-bottom: 5px;max-width: 100%;box-sizing: border-box;min-height: 1em;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">1.<\/span><span style=\"max-width: 100%;font-size: 14px;text-decoration: underline;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzA4MzgzMDM5Mg==&amp;mid=2650626893&amp;idx=1&amp;sn=4fe729f0d5639f9a8c1a33927a51f64a&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u7b2c91\u671f\u8bba\u575b\u4e28FDA\u4e13\u5bb6\u56e2\u9886\u822a\u65b0\u836f\u4e2d\u7f8e\u53cc\u62a5\u4e4b\u8def<\/a><\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);box-sizing: border-box !important;overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);text-align: center;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><a href=\"https:\/\/mp.weixin.qq.com\/s?__biz=MzU2MDY5MzA0OQ==&amp;mid=2247484428&amp;idx=1&amp;sn=d7540b3b4d54422e4996085f2bbc0079&amp;chksm=fc056e5acb72e74cec1843e4eb3f9cf04dcf6ea93b9d8448da418734b13b6440111ca014de9a&amp;token=1732418045&amp;lang=zh_CN&amp;scene=21#wechat_redirect\" target=\"_blank\"  style=\"-webkit-tap-highlight-color: rgba(0, 0, 0, 0);max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span class=\"js_jump_icon h5_image_link\"  style=\"max-width: 100%;line-height: 0;top: auto;left: auto;right: auto;bottom: auto;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><img class=\"rich_pages __bg_gif\"      style=\"box-sizing: border-box !important;overflow-wrap: break-word !important;visibility: visible !important;width: 677px !important;\" src=\"http:\/\/www.05921.net\/wp-content\/uploads\/2019\/04\/0-1555470507.gif\" alt=\"\u5236\u836f\u516c\u53f8\u7684\u4e0b\u4e00\u4e2a\u6398\u91d1\u4e4b\u5730\uff1a\u53d8\u6784\u4f4d\u70b9\u8c03\u63a7allosteric modulator\u7684\u5f00\u53d1\" title=\"\u5236\u836f\u516c\u53f8\u7684\u4e0b\u4e00\u4e2a\u6398\u91d1\u4e4b\u5730\uff1a\u53d8\u6784\u4f4d\u70b9\u8c03\u63a7allosteric modulator\u7684\u5f00\u53d1\"  \/><\/span><\/a><\/p>\n<p style=\"white-space: normal;max-width: 100%;box-sizing: border-box;min-height: 1em;letter-spacing: 0.544px;background-color: rgb(255, 255, 255);overflow-wrap: break-word !important;\"><br style=\"max-width: 100%;box-sizing: border-box;overflow-wrap: break-word !important;\"  \/><\/p>\n<p style=\"white-space: normal;max-width: 100%;min-height: 1em;background-color: rgb(255, 255, 255);letter-spacing: 0.582857px;box-sizing: border-box !important;overflow-wrap: break-word !important;\"><span style=\"max-width: 100%;font-size: 14px;box-sizing: border-box !important;overflow-wrap: break-word !important;\">\u662f\u4e00\u4e2a\u5f00\u653e\uff0c\u7531\u81ea\u613f\u8005\u7ec4\u6210\u7684\u56e2\u4f53\uff0c\u7531\u4ee5\u4e0b\u6210\u5458\u7ec4\u6210\uff1aVoyager88\uff0c\u96f7\u8bfa\u5c9b\uff0cHerman\uff0c\u6885\u5e0c\uff0c\u6587\u7af9\uff0cduke\uff0c\u5360\u5c0f\u5175\uff0c\u9526\u5fc3\u7ee3\u53e3\uff0c\u591a\u5df4\u80fa\uff0c\u745c\u513f\uff0c\u5b50\u708e\uff0c\u514b\u683c\u83ab\uff0cSophia&nbsp;\uff0c\u5076\u9635\u96e8\uff0c\u96f6\u4e0b274\u2103\uff0cHelen\uff0c\u7b49\u7b49\uff0cZMJ\uff0c\u6da6\u513f\uff0c\u4e91\u5377\u3001\u4e8c\u53cb\u6728\u3001\u7f8a\u7f8a\u3001wonger\u3001Jerry\u3001Admiral\u3001\u5723\u624b\u5c0f\u6bd2\u7269\u3001\u9b54\u9b3c\u6df1\u767d\u8272\u3001\u90ed\u5927\u4fa0\u3001\u8427\u6708\u3001\u6c22\u6c14\u53d1\u751f\u5668\u3001\u8c01\u3001\u8d1d\u58f3\u91cc\u7684\u4e7e\u5764\u3001Freesky\u548c\u66fe\u6587\u4eae\u3002\u6b22\u8fce\u6709\u5fd7\u4e4b\u58eb\u52a0\u5165\u6211\u4eec\u56e2\u961f\u3002\u6295\u7a3f\u3001\u5408\u4f5c\u3001\u52a0\u4e13\u4e1a\u7fa4\u8bf7\u52a0\u5fae\u4fe1437180999\uff0c\u4e8c\u5343\u4ebaQQ\u7fa422711855\u3002<\/span><\/p>\n<p 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[&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":83931,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/83930"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=83930"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/83930\/revisions"}],"predecessor-version":[{"id":83937,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/83930\/revisions\/83937"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/83931"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=83930"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=83930"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=83930"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}