{"id":84685,"date":"2019-04-12T00:00:50","date_gmt":"2019-04-17T03:15:06","guid":{"rendered":"http:\/\/www.05921.net\/index.php\/84685\/"},"modified":"2019-04-17T11:15:09","modified_gmt":"2019-04-17T03:15:09","slug":"ecf33e4fc0","status":"publish","type":"post","link":"https:\/\/www.05921.net\/index.php\/84685\/","title":{"rendered":"\u4e13\u6ce8\u4e8e\u5f00\u53d1\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5AAV\u7597\u6cd5\u7684Voyager Therapeutics"},"content":{"rendered":"
\n

\"\u4e13\u6ce8\u4e8e\u5f00\u53d1\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5AAV\u7597\u6cd5\u7684Voyager<\/p>\n

\n
\n

Voyager Therapeutics\u4e13\u6ce8\u4e8e\u5f00\u53d1\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684AAV\u57fa\u56e0\u7597\u6cd5\uff0c\u5176\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u5019\u9009\u4ea7\u54c1VY-AADC\u57281b\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u53d6\u5f97\u521d\u6b65\u7684\u6548\u679c\u3002\u4eca\u5e742\u6708\uff0cVoyager Therapeutics\u4e0eAbbVie\u6269\u5927\u5408\u4f5c\uff0c\u5171\u540c\u5f00\u53d1\u9488\u5bf9\u5e15\u91d1\u68ee\u75c7\u548c\u963f\u5c14\u5179\u6d77\u9ed8\u75c5\u7684AAV\u57fa\u56e0\u7597\u6cd5\u3002<\/p>\n


<\/section>\n

\n
\u4e13\u6ce8\u4e8e\u5f00\u53d1\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5AAV\u7597\u6cd5\u7684Voyager Therapeutics<\/section>\n
\"\u4e13\u6ce8\u4e8e\u5f00\u53d1\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5AAV\u7597\u6cd5\u7684Voyager<\/section>\n
by<\/section>\n
TiPLab \u6728\u6843<\/section>\n<\/section>\n
\n
\u25bc<\/section>\n

AAV\u57fa\u56e0\u6cbb\u7597\u516c\u53f8Voyager<\/h1>\n

Voyager Therapeutics\u6210\u7acb\u4e8e2013\u5e74\uff0c\u603b\u90e8\u4f4d\u4e8e\u5251\u6865\uff0c\u4e13\u6ce8\u4e8e\u5f00\u53d1\u65b0\u578bAAV\u57fa\u56e0\u7597\u6cd5\u4ee5\u6cbb\u7597\u4e25\u91cd\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5<\/strong>\u3002<\/p>\n

\"\u4e13\u6ce8\u4e8e\u5f00\u53d1\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5AAV\u7597\u6cd5\u7684Voyager<\/p>\n

Voyager\u7684\u4ea7\u54c1\u7ebf\u4e3b\u8981\u5305\u62ec\uff1a<\/p>\n

\n
\n
\n

VY-AADC<\/span><\/strong>\uff0c\u7528\u4e8e\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\uff1b<\/p>\n

VY-SOD102<\/span><\/strong>\uff0c\u7528\u4e8e\u5355\u57fa\u56e0\u5f62\u5f0f\u7684\u808c\u840e\u7f29\u4fa7\u7d22\u786c\u5316\u75c7 (ALS)\uff1b<\/p>\n

VY-HTT01<\/span><\/strong>\uff0c\u7528\u4e8e\u6cbb\u7597\u4ea8\u5ef7\u987f\u6c0f\u75c5\uff1b<\/p>\n

VY-FXN01<\/span><\/strong>\uff0c\u7528\u4e8e\u5f17\u91cc\u5fb7\u8d56\u5e0c\u7684\u5171\u6d4e\u5931\u8c03\uff1b<\/p>\n

T<\/span><\/strong>au\u548c\u03b1-\u7a81\u89e6\u6838\u86cb\u767d (\u03b1-synuclein)\u9879\u76ee<\/span><\/strong>\uff0c\u7528\u4e8e\u6cbb\u7597\u5305\u62ec\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u548c\u5e15\u91d1\u68ee\u75c5\u7b49\u3002<\/p>\n<\/section>\n<\/section>\n<\/blockquote>\n

Voyager\u76ee\u524d\u5df2\u7ecf\u4e0eGenzyme\u3001Neurocrine\uff0cAbbVie\u548c\u9ebb\u7701\u5927\u5b66\u533b\u5b66\u9662 (UMMS)\u8fdb\u884c\u5e7f\u6cdb\u7684\u6218\u7565\u5408\u4f5c<\/span><\/strong>\u3002\u53e6\u5916\uff0c\u8fd8\u4e0eUMMS\u3001\u52a0\u5dde\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821\u548c\u65af\u5766\u798f\u5927\u5b66\u7b7e\u8ba2\u4e86\u6280\u672f\u8bb8\u53ef\u534f\u8bae<\/span><\/strong>\u3002<\/p>\n

\"\u4e13\u6ce8\u4e8e\u5f00\u53d1\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5AAV\u7597\u6cd5\u7684Voyager<\/p>\n

\u53c2\u89c1\uff1aVoyager\u5b98\u7f51<\/p>\n

Voyager\u5e73\u53f0\u6280\u672f\u7528\u4e8e\u5f00\u53d1\u51fa\u72ec\u7279\u7684AAV\u57fa\u56e0\u7597\u6cd5\uff0c\u901a\u8fc7AAV\u8f7d\u4f53\u6291\u5236\u75be\u75c5\u76f8\u5173\u7684\u57fa\u56e0\u8868\u8fbe\uff0c\u589e\u52a0\u7f3a\u5931\u86cb\u767d\u8d28\u7684\u8868\u8fbe\uff0c\u6216\u8868\u8fbe\u6cbb\u7597\u6027\u6297\u4f53<\/strong>\u3002<\/p>\n

\u25bc<\/section>\n

\u57fa\u56e0\u6cbb\u7597\u5e73\u53f0\u6280\u672f<\/h1>\n

Voyager\u65e8\u5728\u901a\u8fc7\u57fa\u56e0\u66ff\u6362<\/span><\/strong>\u548c\u57fa\u56e0\u6c89\u9ed8<\/span><\/strong>\u7684\u65b9\u6cd5\u6765\u6cbb\u7597\u75be\u75c5\uff0c\u57fa\u56e0\u7f6e\u6362\u65e8\u5728\u6062<\/span><\/strong>\u590d\u86cb\u767d\u8d28\u7684\u8868\u8fbe<\/span><\/strong>\uff0c\u57fa\u56e0\u6c89\u9ed8\u65e8\u5728\u51cf\u5c11\u75c5\u7406\u6027\u7a81\u53d8\u86cb\u767d\u7684\u8868\u8fbe<\/span><\/strong>\u3002\u6b64\u5916\uff0cVoyager\u8fd8\u901a\u8fc7\u5411\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf (CNS)\u9012\u9001\u5355\u514b\u9686\u6297\u4f53\u6cbb\u7597\u75be\u75c5\u6216\u4f7f\u7528\u57fa\u56e0\u7f16\u8f91\u6765\u7ea0\u6b63\u7ec6\u80de\u57fa\u56e0\u7ec4\u3002<\/p>\n

Voyager\u7684\u57fa\u56e0\u5e73\u53f0\u6280\u672f\u4e3b\u8981\u5305\u62ecAAV\u8f7d\u4f53\u7684\u8bbe\u8ba1\u3001AAV\u7684\u89c4\u6a21\u5316\u5236\u5907\u548cAAV\u57fa\u56e0\u8f7d\u4f53\u7684\u9012\u9001<\/strong>\u3002<\/p>\n

AAV\u8f7d\u4f53\u7684\u5173\u952e\u7ec4\u5206\u5305\u62ec\uff1a\u8863\u58f3\uff1b<\/span><\/strong>\u6cbb\u7597\u57fa\u56e0\u6216\u8f6c\u57fa\u56e0\uff1b<\/span><\/strong>\u542f\u52a8\u5b50\u6216\u9a71\u52a8\u8f6c\u57fa\u56e0\u8868\u8fbe\u7684DNA\u5e8f\u5217<\/span><\/strong>\u3002<\/p>\n

Voyager\u56e2\u961f\u6210\u5458\u53d1\u73b0\u4e86\u8bb8\u591a\u5df2\u77e5\u7684\u5929\u7136AAV\u8863\u58f3\uff0c\u5e76\u57fa\u4e8e\u6b64\u5f00\u53d1\u4e86\u6709\u6f5c\u529b\u7684\u57fa\u56e0\u5de5\u7a0bAAV\u8863\u58f3\uff0c\u4f8b\u5982\u66f4\u9ad8\u7684\u751f\u7269\u6548\u529b\u3001\u589e\u5f3a\u7684\u7ec4\u7ec7\u7279\u5f02\u6027\u4ee5\u53ca\u589e\u5f3a\u7684\u8840\u8111\u5c4f\u969c\u7a7f\u900f\u6027<\/strong>\u3002<\/p>\n

Voyager\u62e5\u6709\u81f3\u5c1110\u4e2a\u6d89\u53ca\u8863\u58f3\u548c\u8f7d\u4f53\u5de5\u7a0b\u5316\u7684\u4e13\u5229\u5bb6\u65cf<\/span><\/strong>\uff0c\u6bd4\u5982\uff1a<\/p>\n

\n
\n
\n

PCT\/US2015\/034799\u6d89\u53ca\u7f16\u7801\u5d4c\u5408\u8863\u58f3\u86cb\u767d\u7684AAV\u6838\u82f7\u9178\uff1b<\/p>\n

PCT\/US2015\/060564\u4e13\u5229\u5bb6\u65cf\u6d89\u53ca\u5305\u542b\u7f16\u7801miRNA\u7684AAV\u8f7d\u4f53\uff0c\u53ef\u7528\u4e8e\u57fa\u56e0\u6c89\u9ed8\uff1b<\/p>\n

PCT\/US2017\/030054\u6d89\u53ca\u5305\u542b\u53cd\u5411\u672b\u7aef\u91cd\u590d\uff08ITR\uff09\u533a\u548c\u6709\u6548\u8d1f\u8f7d\u533a\u7684\u75c5\u6bd2\u57fa\u56e0\u7ec4\u7684AAV\u9897\u7c92\uff1b<\/p>\n

PCT\/US2018\/045088\u4e13\u5229\u5bb6\u65cf\u6d89\u53ca\u4e00\u79cd\u53ef\u4ee5\u7a7f\u8fc7\u8840\u8111\u5c4f\u969c\u7684AAV\u9897\u7c92\u3002<\/p>\n<\/section>\n<\/section>\n<\/blockquote>\n

\u4e3a\u4e86\u5b9e\u73b0\u9ad8\u8d28\u91cf\u7684\u5546\u4e1a\u5316\u89c4\u6a21\u5236\u9020\uff0cVoyager\u4f7f\u7528\u6746\u72b6\u75c5\u6bd2\/Sf9 AAV\u751f\u4ea7\u7cfb\u7edf\u4ee5\u51cf\u5c11DNA\u6742\u8d28\u7684\u5f15\u5165\u548c\u7a7a\u8863\u58f3\u7684\u6bd4\u7387<\/strong>\u3002Voyager\u4eceNIH\u83b7\u5f97\u4e86\u76f8\u5173\u4e13\u5229\u8d44\u4ea7\u7684\u975e\u72ec\u5360\u8bb8\u53ef<\/strong>\u3002<\/p>\n

\u25bc<\/section>\n

\u7528\u4e8e\u8111\u5185\u6ce8\u5c04\u7684VTAG<\/h1>\n

\u4e3a\u4e86\u66f4\u597d\u5730\u8fdb\u884cAAV\u58f3\u6838\u6ce8\u5c04\uff0cVoyager\u4f7f\u7528\u78c1\u5171\u632f\u6210\u50cf (MRI)\u5e2e\u52a9\u533b\u751f\u5728\u672f\u4e2d\u5b9e\u65f6\u89c2\u5bdfVY-AADC\u5411\u58f3\u6838\u7684\u4f20\u9012<\/strong>\uff0c\u4ee5\u907f\u514d\u672f\u4e2d\u51fa\u8840\u7684\u98ce\u9669\u5e76\u6700\u5927\u5316\u58f3\u6838\u7684\u8986\u76d6\u8303\u56f4\u3002<\/p>\n

\u57fa\u4e8e\u6b64\uff0cVoyager\u4e13\u95e8\u5f00\u53d1\u4e86\u4e00\u79cd\u5b9e\u65f6MRI\u6210\u50cf\u8bbe\u5907Voyager Trajectory Array Guide (V-TAG)<\/span><\/strong>\uff0c\u5e76\u4e8e2018\u5e747\u6708\u83b7\u5f97\u4e86FDA\u7684510(k)\u8bb8\u53ef\u3002<\/p>\n

\u9488\u5bf9V-TAG\u7cfb\u7edf\u7684\u5176\u4e2d\u4e24\u4e2a\u4e13\u5229\u5bb6\u65cf<\/span><\/strong>\u5206\u522b\u4e3a\uff1a<\/p>\n

\n
\n
\n

\u6d89\u53ca\u4e00\u79cd\u78c1\u5171\u632f\u6210\u50cf\uff08MRI\uff09\u8f85\u52a9\u9776\u5411\u53d7\u8bd5\u8005\u7684\u6240\u9700\u533a\u57df\u7684\u65b9\u6cd5\u7684PCT\/US2017\/049191\u4e13\u5229\u5bb6\u65cf\uff1b<\/p>\n

\u6d89\u53ca\u4e00\u79cdV-TAG\u7cfb\u7edf\u7684PCT\/US2018\/042391\u4e13\u5229\u5bb6\u65cf\u3002<\/p>\n<\/section>\n<\/section>\n<\/blockquote>\n

\u25bc<\/section>\n

VY-AADC<\/h1>\n

\u5e15\u91d1\u68ee\u75c5 (Parkinson\u2019s disease, PD)\u662f\u4e00\u79cd\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u7684\u6162\u6027\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5<\/span><\/strong>\uff0c\u5728\u5168\u7403\u6709\u5927\u7ea6600\u4e07\u540d\u60a3\u8005\u3002<\/p>\n

\u5728\u5065\u5eb7\u4eba\u7fa4\u4e2d\uff0c\u5927\u8111\u9ed1\u8d28\u4e2d\u7684\u591a\u5df4\u80fa\u795e\u7ecf\u5143\u901a\u8fc7AADC\u9176 (aromatic l-amino acid decarboxylase)\u50ac\u5316\u5de6\u65cb\u591a\u5df4\u4ea7\u751f\u591a\u5df4\u80fa\uff0c\u5e76\u5c06\u5176\u91ca\u653e\u81f3\u591a\u5df4\u80fa\u53d7\u4f53\u6240\u5728\u7684\u58f3\u6838\u4e2d\u3002<\/p>\n

\u5728PD\u60a3\u8005\u4e2d\uff0c\u9ed1\u8d28\u4e2d\u7684\u591a\u5df4\u80fa\u795e\u7ecf\u5143\u9000\u5316\u548cAADC\u9176\u4e27\u5931\u5f71\u54cd\u8fd0\u52a8\u795e\u7ecf\u7cfb\u7edf\uff0c\u5bfc\u81f4\u98a4\u6296\u548c\u80a2\u4f53\u50f5\u786c\u7b49\u8fd0\u52a8\u969c\u788d<\/span><\/strong>\u3002<\/p>\n

VY-AADC\u662f\u4e00\u79cd\u5305\u542b\u7f16\u7801AADC\u9176cDNA\u7684AAV2\uff0c\u901a\u8fc7\u4e00\u6b21\u6027\u7684\u58f3\u6838\u6ce8\u5c04\uff0c\u5728\u591a\u5df4\u80fa\u53d7\u4f53\u6240\u5728\u7684\u58f3\u6838\u795e\u7ecf\u5143\u4e2d\u8868\u8fbeAADC\uff0c\u5c06\u5de6\u65cb\u591a\u5df4\u8f6c\u5316\u4e3a\u591a\u5df4\u80fa<\/strong>\uff0c\u4ece\u800c\u6062\u590d\u60a3\u8005\u7684\u8fd0\u52a8\u529f\u80fd\u3002<\/p>\n

\"\u4e13\u6ce8\u4e8e\u5f00\u53d1\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5AAV\u7597\u6cd5\u7684Voyager<\/p>\n

\u53c2\u89c1\uff1aVoyager\u5b98\u7f51<\/p>\n

Neurocrine\u548cVoyager\u4e8e2019\u5e743\u6708\u516c\u5e03\u4e86VY-AADC 1b\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u4e2d\u671f\u7ed3\u679c\uff0c\u8868\u660e\u4f7f\u7528\u78c1\u5171\u632f\u6210\u50cf\u6307\u5bfc\u8fdb\u884c\u672f\u4e2d\u76d1\u6d4b\uff0c\u53ef\u4ee5\u4fc3\u8fdb\u57fa\u56e0\u6cbb\u7597\u7684\u9776\u5411\u9012\u9001\u3002VY-AADC\u7684\u65bd\u7528\u5bfc\u81f4AADC\u9176\u7684\u8868\u8fbe\u5448\u73b0\u5242\u91cf\u4f9d\u8d56\u6027\u7684\u589e\u52a0\uff0c\u8010\u53d7\u6027\u826f\u597d\uff0c\u4e14\u672a\u53d1\u73b0\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6 (SAEs)<\/strong>\u3002<\/p>\n

VY-AADC\u76f8\u5173\u7684\u4e13\u5229\u7533\u8bf7<\/h2>\n

Voyager\u62e5\u6709\u56db\u4e2a\u56f4\u7ed5VY-AADC\u7684\u4e13\u5229\u5bb6\u65cf<\/span><\/strong>\uff0c\u5206\u522b\u6d89\u53caVY-AADC\u7684\u591a\u6838\u82f7\u9178\u3001\u6cbb\u7597\u7528\u9014\u7b49\u4e3b\u9898\uff0c\u6bd4\u5982\uff1a<\/p>\n

\n
\n
\n

PCT\/US2015\/059201\u4e13\u5229\u5bb6\u65cf<\/span><\/strong>\u6d89\u53ca\u4e00\u79cdAADC\u591a\u6838\u82f7\u9178\u3002\u76ee\u524d\u5305\u542b\u81f3\u5c1117\u4ef6\u4e13\u5229\u7533\u8bf7\uff0c\u5e76\u4e14\u5bb6\u65cf\u6210\u5458\u8fd8\u53ef\u80fd\u4e0d\u65ad\u589e\u52a0\u3002\u5176\u8fdb\u5165\u6fb3\u5927\u5229\u4e9a\u7684\u7533\u8bf7\u5df2\u7ecf\u83b7\u5f97\u6388\u6743 (AU2015343037B2)\u3002\u8fdb\u5165\u7f8e\u56fd\u56fd\u5bb6\u9636\u6bb5\u7684\u4e13\u5229\u7533\u8bf7 (US20170333538A1)\u53ca\u5176\u4e09\u4e2a\u5ef6\u7eed\u7533\u8bf7\u4ecd\u5904\u4e8e\u5ba1\u67e5\u9636\u6bb5\u3002\u5e9e\u5927\u7684\u4e13\u5229\u5bb6\u65cf\u663e\u793a\u51faVoyager\u65e5\u540e\u5728\u4ea7\u54c1\u5e02\u573a\u5e03\u5c40\u65b9\u9762\u7684\u96c4\u5fc3<\/strong>\u3002<\/p>\n

PCT\/US2016\/044627\u4e13\u5229\u5bb6\u65cf<\/span><\/strong>\u6d89\u53ca\u4f7f\u7528\u5305\u542bAADC\u6838\u9178\u7684AAV\u9897\u7c92\u6cbb\u7597AACD\u7f3a\u4e4f\u75be\u75c5\u7684\u7528\u9014\u3002<\/p>\n

PCT\/US2018\/037437<\/span><\/strong>\u6d89\u53ca\u4e00\u79cd\u6539\u8fdb\u7684AADC\u591a\u6838\u82f7\u9178\u6784\u5efa\u4f53\u3002<\/p>\n<\/section>\n<\/section>\n<\/blockquote>\n

\u25bc<\/section>\n

AbbVie\u548cVoyager\u8fbe\u6210\u5408\u4f5c<\/h1>\n

2019\u5e742\u6708\uff0cAbbVie\u548cVoyager\u6269\u5927\u5408\u4f5c\u8303\u56f4\uff0c\u65e8\u5728\u5f00\u53d1\u548c\u5546\u4e1a\u5316\u9488\u5bf9\u03b1-\u7a81\u89e6\u6838\u86cb\u767d (\u03b1-synuclein)\u7684\u8f7d\u4f53\u5316\u6297\u4f53<\/span><\/strong>\uff0c\u7528\u4e8e\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u3002\u6b64\u524d\uff0c\u53cc\u65b9\u5df2\u7ecf\u8fbe\u6210\u5408\u4f5c\u5171\u540c\u5f00\u53d1\u8868\u8fbe\u6297tau\u6297\u4f53\u7684\u57fa\u56e0\u7597\u6cd5\u7528\u6765\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u3002\u8fd9\u4e24\u9879\u5408\u4f5c\u7684\u4ef7\u503c\u9884\u8ba1\u8d85\u8fc715\u4ebf\u7f8e\u5143<\/span><\/strong>\u3002<\/p>\n

Voyager\u7684\u8f7d\u4f53\u5316\u6297\u4f53\u6280\u672f\u901a\u8fc7\u4e00\u6b21\u6027\u9759\u8109\u7ed9\u836f\uff0c\u5229\u7528\u8840\u8111\u5c4f\u969c\u7a7f\u900f\u6027\u7684AAV\u8863\u58f3\u63d0\u4f9b\u7f16\u7801\u6cbb\u7597\u6027\u6297\u4f53\u7684\u57fa\u56e0<\/strong>\u3002AbbVie\u6b63\u662f\u770b\u91cd\u4e86\u8be5\u6280\u672f\u7684\u6f5c\u529b\u800c\u4e0eVoyager\u6269\u5927\u4e86\u5408\u4f5c\u8303\u56f4\u3002<\/p>\n

Voyager\u62e5\u6709\u81f3\u5c11\u4e09\u4e2a\u4e13\u5229\u5bb6\u65cf\u6d89\u53ca\u8f7d\u4f53\u5316\u6297\u4f53\u53ca\u5176\u7597\u6cd5<\/span><\/strong>\uff0c\u6bd4\u5982\uff1aPCT\/US2017\/030061\u6d89\u53ca\u5305\u542b\u7f16\u7801\u6297\u4f53\u6838\u9178\u7247\u6bb5\u7684AAV\u9897\u7c92\u3002<\/p>\n

\u25bc
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\u4e13\u5229\u8d44\u4ea7\u7684\u4ef7\u503c<\/h1>\n

\u636eVoyager\u62ab\u9732\uff0c\u5176\u76ee\u524d\u5728\u5168\u7403\u4e00\u5171\u62e5\u6709\u63a5\u8fd1200\u4ef6\u4e13\u5229\u7533\u8bf7<\/strong>\uff0c\u8fd9\u4e9b\u5e9e\u5927\u7684\u4e13\u5229\u7533\u8bf7\u53ef\u4ee5\u4e3aVoyager\u63d0\u4f9b\u66f4\u591a\u884c\u52a8\u7684\u81ea\u7531<\/strong>\uff0c\u8fd9\u610f\u5473\u7740Voyager\u80fd\u591f\u4ee5\u5bf9\u81ea\u5df1\u6700\u6709\u5229\u7684\u65b9\u5f0f\u786e\u5b9a\u7ade\u4e89\u7684\u65b9\u5f0f\u548c\u65f6\u673a\uff1b<\/p>\n

Voyager\u8fd8\u4e0e\u591a\u5bb6\u673a\u6784\u8fbe\u6210\u5408\u4f5c\u5411\u5916\u90e8\u8bb8\u53ef\u5176\u5305\u62ec\u4e13\u5229\u8d44\u4ea7\u7684\u77e5\u8bc6\u4ea7\u6743<\/strong>\uff0c\u53ef\u89c1\u4e13\u5229\u8d44\u4ea7\u95f4\u63a5\u4e5f\u4e3a\u5176\u5e26\u6765\u4e86\u5927\u91cf\u7684\u73b0\u91d1\u6d41<\/strong>\u3002<\/p>\n

\u6b64\u5916\uff0cVoyager\u8fd8\u4ece\u5916\u90e8\u8bb8\u53ef\u4e86\u90e8\u5206\u4e13\u5229\u5bb6\u65cf<\/span><\/strong>\uff0c\u5e2e\u52a9Voyager\u5feb\u901f\u6269\u5145\u6709\u6f5c\u529b\u7684\u7814\u53d1\u7ba1\u7ebf<\/strong>\u3002\u6bd4\u5982\uff1a<\/p>\n

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\u4eceNIH\u8bb8\u53ef\u5728\u6606\u866b\u7ec6\u80de\u4e2d\u751f\u4ea7AAV\u7684\u4e13\u5229\u5bb6\u65cf\uff1b<\/p>\n

\u4eceStanford\u3001REGENX\u548c\u52a0\u5dde\u7406\u5de5\u5b66\u9662\u8bb8\u53efAAV\u8863\u58f3\u7684\u4e13\u5229\u5bb6\u65cf\u7b49\u3002<\/p>\n<\/section>\n<\/section>\n<\/blockquote>\n<\/section>\n

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* \u4ee5\u4e0a\u6587\u5b57\u7531TiPLab\u539f\u521b\uff0c\u4ec5\u4e3a\u4fc3\u8fdb\u8ba8\u8bba\u4e0e\u4ea4\u6d41\uff0c\u4e0d\u6784\u6210\u6cd5\u5f8b\u610f\u89c1\u6216\u54a8\u8be2\u5efa\u8bae\u3002<\/strong><\/p>\n

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\u5ef6\u4f38\u9605\u8bfb\uff1a<\/p>\n

AAV\u57fa\u56e0\u6cbb\u7597\u9886\u57df\u65b0\u79c0Regenxbio<\/a><\/a>
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\"\u4e13\u6ce8\u4e8e\u5f00\u53d1\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5AAV\u7597\u6cd5\u7684Voyager
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\"\u4e13\u6ce8\u4e8e\u5f00\u53d1\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5AAV\u7597\u6cd5\u7684Voyager<\/p>\n

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TiPLab\u5b98\u5ba3\uff1a\u62db\u8058<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

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TiPLab\u89c6\u56e2\u961f\u4e3a\u6838\u5fc3\u8d44\u4ea7\uff0c\u66f4\u662f\u5171\u540c\u53d1\u5c55\u7684\u4eb2\u5bc6\u4f19\u4f34<\/span><\/span><\/p>\n

\u6211\u4eec\u63a8\u5d07\u4e25\u8083\u6d3b\u6cfc\u7684\u6781\u5ba2\u6c1b\u56f4\uff0c<\/span>\u7ed9\u4e88\u5145\u5206\u7684\u6210\u957f\u7a7a\u95f4<\/span><\/p>\n

\u6211\u4eec\u5e0c\u671b\u4f60\u80fd\u72ec\u5f53\u4e00\u9762\uff0c<\/span>\u5728\u5de5\u4f5c\u4e2d\u4e0d\u65ad\u5b9e\u73b0\u81ea\u8eab\u4ef7\u503c<\/span><\/p>\n


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\u4f60\u5c31\u662f\u6211\u4eec\u5bfb\u627e\u7684\uff0c\u613f\u610f\u4e0b\u82e6\u529f\u592b\u7684\u5b66\u4e60\u8005\u5417\uff1f<\/span><\/p>\n

\u516c\u53f8\u53ca\u804c\u4f4d\u8be6\u60c5\u8bf7\u6233\uff1a<\/span>Positions Available<\/strong><\/a><\/span><\/p>\n

CV\u8bf7\u53d1\u9001\u81f3\uff1ainfo@tip-lab.com<\/span><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section><\/div>\n","protected":false},"excerpt":{"rendered":"

Voyager Therapeutics\u4e13\u6ce8\u4e8e\u5f00\u53d1\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684AAV\u57fa\u56e0\u7597\u6cd5\uff0c\u5176\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u5019\u9009 […]<\/p>\n","protected":false},"author":1,"featured_media":84686,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/84685"}],"collection":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/comments?post=84685"}],"version-history":[{"count":1,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/84685\/revisions"}],"predecessor-version":[{"id":84694,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/posts\/84685\/revisions\/84694"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media\/84686"}],"wp:attachment":[{"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/media?parent=84685"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/categories?post=84685"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.05921.net\/index.php\/wp-json\/wp\/v2\/tags?post=84685"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}